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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HRAS-SCT (FusionGDB2 ID:37409)

Fusion Gene Summary for HRAS-SCT

check button Fusion gene summary
Fusion gene informationFusion gene name: HRAS-SCT
Fusion gene ID: 37409
HgeneTgene
Gene symbol

HRAS

SCT

Gene ID

3265

6343

Gene nameHRas proto-oncogene, GTPasesecretin
SynonymsC-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras-
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionGTPase HRasGTP- and GDP-binding peptide BHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncogene homologHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinp19 H-RasIDX proteintransformation gene: secretinprepro-secretin
Modification date2020032920200313
UniProtAcc

P01112

.
Ensembl transtripts involved in fusion geneENST00000397594, ENST00000397596, 
ENST00000451590, ENST00000417302, 
ENST00000311189, ENST00000468682, 
ENST00000176195, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HRAS [Title/Abstract] AND SCT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHRAS(532631)-SCT(626530), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHRAS

GO:0001934

positive regulation of protein phosphorylation

22065586

HgeneHRAS

GO:0007050

cell cycle arrest

9054499

HgeneHRAS

GO:0007093

mitotic cell cycle checkpoint

9054499

HgeneHRAS

GO:0007265

Ras protein signal transduction

23027131

HgeneHRAS

GO:0008284

positive regulation of cell proliferation

9765203

HgeneHRAS

GO:0008285

negative regulation of cell proliferation

9054499

HgeneHRAS

GO:0010629

negative regulation of gene expression

23027131

HgeneHRAS

GO:0010863

positive regulation of phospholipase C activity

11022048

HgeneHRAS

GO:0030335

positive regulation of cell migration

23027131

HgeneHRAS

GO:0034260

negative regulation of GTPase activity

23027131

HgeneHRAS

GO:0043406

positive regulation of MAP kinase activity

23027131

HgeneHRAS

GO:0043410

positive regulation of MAPK cascade

9765203

HgeneHRAS

GO:0043547

positive regulation of GTPase activity

23027131

HgeneHRAS

GO:0045944

positive regulation of transcription by RNA polymerase II

22065586|23027131

HgeneHRAS

GO:0046330

positive regulation of JNK cascade

22065586

HgeneHRAS

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

HgeneHRAS

GO:0071480

cellular response to gamma radiation

16213212

HgeneHRAS

GO:0090303

positive regulation of wound healing

23027131

HgeneHRAS

GO:0090398

cellular senescence

9054499

HgeneHRAS

GO:0098696

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

12202034

HgeneHRAS

GO:1900029

positive regulation of ruffle assembly

23027131

HgeneHRAS

GO:2000251

positive regulation of actin cytoskeleton reorganization

23027131

HgeneHRAS

GO:2000630

positive regulation of miRNA metabolic process

23027131


check buttonFusion gene breakpoints across HRAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SCT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SK-01AHRASchr11

532631

-SCTchr11

626530

-
ChimerDB4BRCATCGA-A1-A0SK-01AHRASchr11

532631

-SCTchr11

626530

-


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Fusion Gene ORF analysis for HRAS-SCT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000397594ENST00000176195HRASchr11

532631

-SCTchr11

626530

-
intron-3CDSENST00000397596ENST00000176195HRASchr11

532631

-SCTchr11

626530

-
intron-3CDSENST00000451590ENST00000176195HRASchr11

532631

-SCTchr11

626530

-
intron-3CDSENST00000417302ENST00000176195HRASchr11

532631

-SCTchr11

626530

-
3UTR-3CDSENST00000311189ENST00000176195HRASchr11

532631

-SCTchr11

626530

-
intron-3CDSENST00000468682ENST00000176195HRASchr11

532631

-SCTchr11

626530

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for HRAS-SCT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HRAS-SCT


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HRAS

P01112

.
FUNCTION: Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed:14500341, ECO:0000269|PubMed:22821884, ECO:0000269|PubMed:9020151}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for HRAS-SCT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HRAS-SCT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HRAS-SCT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HRAS-SCT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHRASC0587248Costello syndrome (disorder)28CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHRASC0007114Malignant neoplasm of skin7CTD_human
HgeneHRASC0037286Skin Neoplasms7CTD_human
HgeneHRASC0007621Neoplastic Cell Transformation5CTD_human
HgeneHRASC0023903Liver neoplasms5CTD_human
HgeneHRASC0024121Lung Neoplasms5CTD_human
HgeneHRASC0242379Malignant neoplasm of lung5CTD_human
HgeneHRASC0345904Malignant neoplasm of liver5CTD_human
HgeneHRASC2239176Liver carcinoma5CTD_human
HgeneHRASC0006142Malignant neoplasm of breast4CGI;CTD_human
HgeneHRASC0019207Hepatoma, Morris4CTD_human
HgeneHRASC0019208Hepatoma, Novikoff4CTD_human
HgeneHRASC0023904Liver Neoplasms, Experimental4CTD_human
HgeneHRASC0086404Experimental Hepatoma4CTD_human
HgeneHRASC0238463Papillary thyroid carcinoma4ORPHANET
HgeneHRASC0678222Breast Carcinoma4CGI;CTD_human
HgeneHRASC1257931Mammary Neoplasms, Human4CTD_human
HgeneHRASC1458155Mammary Neoplasms4CTD_human
HgeneHRASC4704874Mammary Carcinoma, Human4CTD_human
HgeneHRASC0005684Malignant neoplasm of urinary bladder3CGI;CTD_human
HgeneHRASC0005695Bladder Neoplasm3CGI;CTD_human
HgeneHRASC0027659Neoplasms, Experimental3CTD_human
HgeneHRASC0265329Organoid Nevus Phakomatosis3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHRASC2931658Phacomatosis pigmentokeratotica3GENOMICS_ENGLAND;ORPHANET
HgeneHRASC0007137Squamous cell carcinoma2CGI;CTD_human
HgeneHRASC0024623Malignant neoplasm of stomach2CTD_human
HgeneHRASC0024668Mammary Neoplasms, Experimental2CTD_human
HgeneHRASC0027819Neuroblastoma2CGI;CTD_human
HgeneHRASC0038356Stomach Neoplasms2CTD_human
HgeneHRASC0343073Wooly hair2GENOMICS_ENGLAND
HgeneHRASC1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneHRASC0004352Autistic Disorder1CTD_human
HgeneHRASC0006118Brain Neoplasms1CTD_human
HgeneHRASC0007097Carcinoma1CTD_human
HgeneHRASC0007138Carcinoma, Transitional Cell1CGI;CTD_human
HgeneHRASC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneHRASC0017638Glioma1CTD_human
HgeneHRASC0018923Hemangiosarcoma1CTD_human
HgeneHRASC0024667Animal Mammary Neoplasms1CTD_human
HgeneHRASC0025202melanoma1CGI;CTD_human;UNIPROT
HgeneHRASC0026640Mouth Neoplasms1CTD_human
HgeneHRASC0027626Neoplasm Invasiveness1CTD_human
HgeneHRASC0028326Noonan Syndrome1CLINGEN;CTD_human
HgeneHRASC0030354Papilloma1CTD_human
HgeneHRASC0030849Penile Neoplasms1CTD_human
HgeneHRASC0032927Precancerous Conditions1CTD_human
HgeneHRASC0033578Prostatic Neoplasms1CTD_human
HgeneHRASC0036631Seminoma1CTD_human
HgeneHRASC0037999Splenic Neoplasms1CTD_human
HgeneHRASC0040136Thyroid Neoplasm1CTD_human
HgeneHRASC0040411Tongue Neoplasms1CTD_human
HgeneHRASC0041409Turner Syndrome, Male1CTD_human
HgeneHRASC0079772T-Cell Lymphoma1CTD_human
HgeneHRASC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneHRASC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneHRASC0153349Malignant neoplasm of tongue1CTD_human
HgeneHRASC0153381Malignant neoplasm of mouth1CTD_human
HgeneHRASC0153470Malignant neoplasm of spleen1CTD_human
HgeneHRASC0153601Malignant neoplasm of penis1CTD_human
HgeneHRASC0153633Malignant neoplasm of brain1CTD_human
HgeneHRASC0205696Anaplastic carcinoma1CTD_human
HgeneHRASC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneHRASC0205698Undifferentiated carcinoma1CTD_human
HgeneHRASC0205699Carcinomatosis1CTD_human
HgeneHRASC0205874Papilloma, Squamous Cell1CTD_human
HgeneHRASC0205875Papillomatosis1CTD_human
HgeneHRASC0206669Hepatocellular Adenoma1CTD_human
HgeneHRASC0235874Disease Exacerbation1CTD_human
HgeneHRASC0259783mixed gliomas1CTD_human
HgeneHRASC0282313Condition, Preneoplastic1CTD_human
HgeneHRASC0343114Woolly hair nevus1ORPHANET
HgeneHRASC0362030Verrucous epidermal nevus1CTD_human
HgeneHRASC0376358Malignant neoplasm of prostate1CTD_human
HgeneHRASC0431380Cortical Dysplasia1CTD_human
HgeneHRASC0473574Inflammatory linear verrucous epidermal nevus1CTD_human
HgeneHRASC0496899Benign neoplasm of brain, unspecified1CTD_human
HgeneHRASC0549473Thyroid carcinoma1CGI;CTD_human
HgeneHRASC0555198Malignant Glioma1CTD_human
HgeneHRASC0750974Brain Tumor, Primary1CTD_human
HgeneHRASC0750977Recurrent Brain Neoplasm1CTD_human
HgeneHRASC0750979Primary malignant neoplasm of brain1CTD_human
HgeneHRASC1257925Mammary Carcinoma, Animal1CTD_human
HgeneHRASC1275081Cardio-facio-cutaneous syndrome1CLINGEN;CTD_human
HgeneHRASC1527390Neoplasms, Intracranial1CTD_human
HgeneHRASC1527404Female Pseudo-Turner Syndrome1CTD_human
HgeneHRASC1843181Noonan syndrome-like disorder with loose anagen hair1CLINGEN
HgeneHRASC1955869Malformations of Cortical Development1CTD_human
HgeneHRASC3179502Linear Verrucous Epidermal Nevus1CTD_human
HgeneHRASC3501846Noonan-Like Syndrome With Loose Anagen Hair1CLINGEN
HgeneHRASC3854181Nevus sebaceous1ORPHANET
HgeneHRASC4225426THYROID CANCER, NONMEDULLARY, 21UNIPROT
HgeneHRASC4551602Noonan Syndrome 11CTD_human
HgeneHRASC4552097Nevus Sebaceus of Jadassohn1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneSCTC0004352Autistic Disorder4CTD_human
TgeneSCTC0008340Choledochal Cyst1CTD_human
TgeneSCTC0009439Choledochal Cyst, Type I1CTD_human
TgeneSCTC0032460Polycystic Ovary Syndrome1CTD_human
TgeneSCTC0039231Tachycardia1CTD_human
TgeneSCTC0080203Tachyarrhythmia1CTD_human
TgeneSCTC1136382Sclerocystic Ovaries1CTD_human
TgeneSCTC1257796Choledochal Cyst, Type II1CTD_human
TgeneSCTC1257797Choledochal Cyst, Type III1CTD_human
TgeneSCTC1257798Choledochal Cyst, Type IV1CTD_human
TgeneSCTC1257799Choledochal Cyst, Type V1CTD_human