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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:HS3ST5-HDAC2 (FusionGDB2 ID:37450) |
Fusion Gene Summary for HS3ST5-HDAC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: HS3ST5-HDAC2 | Fusion gene ID: 37450 | Hgene | Tgene | Gene symbol | HS3ST5 | HDAC2 | Gene ID | 222537 | 3066 |
| Gene name | heparan sulfate-glucosamine 3-sulfotransferase 5 | histone deacetylase 2 | |
| Synonyms | 3-OST-5|3OST5|HS3OST5|NBLA04021 | HD2|KDAC2|RPD3|YAF1 | |
| Cytomap | 6q21-q22.1 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | heparan sulfate glucosamine 3-O-sulfotransferase 5h3-OST-5heparan sulfate (glucosamine) 3-O-sulfotransferase 5heparan sulfate 3-O-sulfotransferase 5heparan sulfate 3-OST-5heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5 | histone deacetylase 2YY1-associated factor 1transcriptional regulator homolog RPD3 | |
| Modification date | 20200313 | 20200322 | |
| UniProtAcc | Q8IZT8 | Q92769 | |
| Ensembl transtripts involved in fusion gene | ENST00000312719, ENST00000411826, ENST00000441954, | ENST00000519065, ENST00000398283, ENST00000519108, ENST00000368632, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 2=60 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/60*10)=0 | |
| Context | PubMed: HS3ST5 [Title/Abstract] AND HDAC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | HS3ST5(114489515)-HDAC2(114281182), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HS3ST5 | GO:0006477 | protein sulfation | 12138164 |
| Hgene | HS3ST5 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification | 12138164 |
| Hgene | HS3ST5 | GO:0046596 | regulation of viral entry into host cell | 12138164 |
| Hgene | HS3ST5 | GO:0050819 | negative regulation of coagulation | 12138164 |
| Fusion gene breakpoints across HS3ST5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across HDAC2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8365-01A | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
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Fusion Gene ORF analysis for HS3ST5-HDAC2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000312719 | ENST00000519065 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-3CDS | ENST00000312719 | ENST00000398283 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-5UTR | ENST00000312719 | ENST00000519108 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-5UTR | ENST00000312719 | ENST00000368632 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| intron-3CDS | ENST00000411826 | ENST00000519065 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| intron-3CDS | ENST00000411826 | ENST00000398283 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| intron-5UTR | ENST00000411826 | ENST00000519108 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| intron-5UTR | ENST00000411826 | ENST00000368632 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-3CDS | ENST00000441954 | ENST00000519065 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-3CDS | ENST00000441954 | ENST00000398283 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-5UTR | ENST00000441954 | ENST00000519108 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| 5UTR-5UTR | ENST00000441954 | ENST00000368632 | HS3ST5 | chr6 | 114489515 | - | HDAC2 | chr6 | 114281182 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HS3ST5-HDAC2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for HS3ST5-HDAC2 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HS3ST5 | HDAC2 |
| FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269|PubMed:12138164}. | FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. {ECO:0000269|PubMed:19343227, ECO:0000269|PubMed:21965678}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HS3ST5-HDAC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for HS3ST5-HDAC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HS3ST5-HDAC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HDAC2 | Q92769 | DB00175 | Pravastatin | Inhibitor | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB00277 | Theophylline | Activator | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB00641 | Simvastatin | Inhibitor | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB01076 | Atorvastatin | Inhibitor | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB01095 | Fluvastatin | Inhibitor | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB01223 | Aminophylline | Activator | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB01303 | Oxtriphylline | Activator | Small molecule | Approved |
| Tgene | HDAC2 | Q92769 | DB00227 | Lovastatin | Other | Small molecule | Approved|Investigational |
| Tgene | HDAC2 | Q92769 | DB00313 | Valproic acid | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | HDAC2 | Q92769 | DB02546 | Vorinostat | Inhibitor | Small molecule | Approved|Investigational |
| Tgene | HDAC2 | Q92769 | DB06176 | Romidepsin | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
| Tgene | HDAC2 | Q92769 | DB09091 | Tixocortol | Stimulator | Small molecule | Approved|Withdrawn |
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Related Diseases for HS3ST5-HDAC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | HS3ST5 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | HDAC2 | C0024117 | Chronic Obstructive Airway Disease | 2 | CTD_human |
| Tgene | HDAC2 | C0525045 | Mood Disorders | 2 | PSYGENET |
| Tgene | HDAC2 | C1527303 | Chronic Airflow Obstruction | 2 | CTD_human |
| Tgene | HDAC2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | HDAC2 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | HDAC2 | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | HDAC2 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | HDAC2 | C0018800 | Cardiomegaly | 1 | CTD_human |
| Tgene | HDAC2 | C0023466 | Leukemia, Monocytic, Chronic | 1 | CTD_human |
| Tgene | HDAC2 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Tgene | HDAC2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Tgene | HDAC2 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | HDAC2 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | HDAC2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | HDAC2 | C0239946 | Fibrosis, Liver | 1 | CTD_human |
| Tgene | HDAC2 | C0269102 | Endometrioma | 1 | CTD_human |
| Tgene | HDAC2 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | HDAC2 | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Tgene | HDAC2 | C1383860 | Cardiac Hypertrophy | 1 | CTD_human |
| Tgene | HDAC2 | C1721098 | Replication Error Phenotype | 1 | CTD_human |
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