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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSD17B4-TNFAIP8 (FusionGDB2 ID:37523)

Fusion Gene Summary for HSD17B4-TNFAIP8

check button Fusion gene summary
Fusion gene informationFusion gene name: HSD17B4-TNFAIP8
Fusion gene ID: 37523
HgeneTgene
Gene symbol

HSD17B4

TNFAIP8

Gene ID

3295

25816

Gene namehydroxysteroid 17-beta dehydrogenase 4TNF alpha induced protein 8
SynonymsDBP|MFE-2|MPF-2|PRLTS1|SDR8C1GG2-1|MDC-3.13|NDED|SCC-S2|SCCS2
Cytomap

5q23.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratasetumor necrosis factor alpha-induced protein 8NF-kappa-B-inducible DED-containing proteinTNF-induced protein GG2-1head and neck tumor and metastasis-related proteintumor necrosis factor, alpha induced protein 8
Modification date2020032720200313
UniProtAcc

P51659

.
Ensembl transtripts involved in fusion geneENST00000256216, ENST00000515320, 
ENST00000510025, ENST00000504811, 
ENST00000414835, ENST00000513628, 
ENST00000509514, ENST00000522415, 
ENST00000274456, ENST00000513374, 
ENST00000504771, ENST00000503646, 
ENST00000504642, ENST00000415806, 
Fusion gene scores* DoF score4 X 4 X 4=648 X 5 X 5=200
# samples 511
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/200*10)=-0.862496476250065
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSD17B4 [Title/Abstract] AND TNFAIP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSD17B4(118792063)-TNFAIP8(118728511), # samples:2
HSD17B4(118850741)-TNFAIP8(118728511), # samples:2
TNFAIP8(118604602)-HSD17B4(118872118), # samples:1
TNFAIP8(118604602)-HSD17B4(118809603), # samples:1
TNFAIP8(118604602)-HSD17B4(118842513), # samples:1
Anticipated loss of major functional domain due to fusion event.HSD17B4-TNFAIP8 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSD17B4

GO:0006635

fatty acid beta-oxidation

10400999

HgeneHSD17B4

GO:0008209

androgen metabolic process

7487879

HgeneHSD17B4

GO:0008210

estrogen metabolic process

7487879

HgeneHSD17B4

GO:0036111

very long-chain fatty-acyl-CoA metabolic process

9482850

HgeneHSD17B4

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

9089413


check buttonFusion gene breakpoints across HSD17B4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNFAIP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-JW-A5VL-01AHSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
ChimerDB4STADTCGA-CD-A4MH-01AHSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
ChimerDB4STADTCGA-CD-A4MH-01AHSD17B4chr5

118850741

-TNFAIP8chr5

118728511

+
ChimerDB4CESCTCGA-JW-A5VL-01AHSD17B4chr5

118792063

-TNFAIP8chr5

118728511

+


Top

Fusion Gene ORF analysis for HSD17B4-TNFAIP8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000256216ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000256216ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000256216ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000256216ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000256216ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000515320ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000515320ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000510025ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3UTRENST00000510025ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000504811ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
In-frameENST00000504811ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000504811ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3CDSENST00000414835ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
5UTR-3UTRENST00000414835ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000513628ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000513628ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000509514ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000509514ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000274456HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000513374HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000504771HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000503646HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3CDSENST00000522415ENST00000504642HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
intron-3UTRENST00000522415ENST00000415806HSD17B4chr5

118792063

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000256216ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000256216ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000515320ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000515320ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000510025ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000510025ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000504811ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000504811ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000414835ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000414835ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000513628ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000513628ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
Frame-shiftENST00000509514ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
5CDS-3UTRENST00000509514ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000274456HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000513374HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000504771HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000503646HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3CDSENST00000522415ENST00000504642HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+
3UTR-3UTRENST00000522415ENST00000415806HSD17B4chr5

118850741

+TNFAIP8chr5

118728511

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for HSD17B4-TNFAIP8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HSD17B4chr5118792063+TNFAIP8chr5118728510+7.47E-060.9999925
HSD17B4chr5118850741+TNFAIP8chr5118728510+2.66E-060.9999974
HSD17B4chr5118792063+TNFAIP8chr5118728510+7.47E-060.9999925
HSD17B4chr5118850741+TNFAIP8chr5118728510+2.66E-060.9999974

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for HSD17B4-TNFAIP8


check button Go to

FGviewer for the breakpoints of chr5:118792063-chr5:118728511

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSD17B4

P51659

.
FUNCTION: Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:10671535). {ECO:0000269|PubMed:10671535, ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:8902629, ECO:0000269|PubMed:9089413}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+22413_3737.333333333333336737.0Nucleotide bindingNAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+22513_3740.666666666666664762.0Nucleotide bindingNAD
TgeneTNFAIP8chr5:118792063chr5:118728511ENST000002744560249_830.3333333333333333189.0Coiled coilOntology_term=ECO:0000255
TgeneTNFAIP8chr5:118792063chr5:118728511ENST000005036461349_8310.333333333333334199.0Coiled coilOntology_term=ECO:0000255
TgeneTNFAIP8chr5:118792063chr5:118728511ENST000005047710249_8310.333333333333334199.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224484_60037.333333333333336737.0DomainNote=MaoC-like
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224624_73637.333333333333336737.0DomainNote=SCP2
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225484_60040.666666666666664762.0DomainNote=MaoC-like
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225624_73640.666666666666664762.0DomainNote=SCP2
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123484_6000719.0DomainNote=MaoC-like
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123624_7360719.0DomainNote=SCP2
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224734_73637.333333333333336737.0MotifMicrobody targeting signal
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225734_73640.666666666666664762.0MotifMicrobody targeting signal
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123734_7360719.0MotifMicrobody targeting signal
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224164_16837.333333333333336737.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224196_19937.333333333333336737.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+22475_7637.333333333333336737.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225164_16840.666666666666664762.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225196_19940.666666666666664762.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+22575_7640.666666666666664762.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+12313_370719.0Nucleotide bindingNAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123164_1680719.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123196_1990719.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+12375_760719.0Nucleotide bindingNote=NAD
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+2241_30537.333333333333336737.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224322_62237.333333333333336737.0RegionNote=Enoyl-CoA hydratase 2
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224406_40737.333333333333336737.0Region(3R)-3-hydroxydecanoyl-CoA binding
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000256216+224510_51537.333333333333336737.0Region(3R)-3-hydroxydecanoyl-CoA binding
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+2251_30540.666666666666664762.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225322_62240.666666666666664762.0RegionNote=Enoyl-CoA hydratase 2
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225406_40740.666666666666664762.0Region(3R)-3-hydroxydecanoyl-CoA binding
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000504811+225510_51540.666666666666664762.0Region(3R)-3-hydroxydecanoyl-CoA binding
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+1231_3050719.0RegionNote=(3R)-hydroxyacyl-CoA dehydrogenase
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123322_6220719.0RegionNote=Enoyl-CoA hydratase 2
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123406_4070719.0Region(3R)-3-hydroxydecanoyl-CoA binding
HgeneHSD17B4chr5:118792063chr5:118728511ENST00000515320+123510_5150719.0Region(3R)-3-hydroxydecanoyl-CoA binding


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Fusion Gene Sequence for HSD17B4-TNFAIP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for HSD17B4-TNFAIP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSD17B4-TNFAIP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneHSD17B4P51659DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneHSD17B4P51659DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneHSD17B4P51659DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for HSD17B4-TNFAIP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSD17B4C0342870Bifunctional peroxisomal enzyme deficiency12CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneHSD17B4C0685838Gonadal dysgenesis XX type deafness10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHSD17B4C0282525Adrenoleukodystrophy, Neonatal2CTD_human
HgeneHSD17B4C0282526Hyperpipecolic Acidemia2CTD_human
HgeneHSD17B4C0282528Peroxisomal Disorders2CTD_human
HgeneHSD17B4C0751708Peroxisomal Dysfunction, General2CTD_human
HgeneHSD17B4C0751709Peroxisomal Dysfunction, Multiple2CTD_human
HgeneHSD17B4C0751710Peroxisomal Dysfunction, Single2CTD_human
HgeneHSD17B4C4551721PERRAULT SYNDROME 12GENOMICS_ENGLAND;UNIPROT
HgeneHSD17B4C0037769West Syndrome1CTD_human
HgeneHSD17B4C0043459Zellweger Syndrome1CTD_human
HgeneHSD17B4C0393698Cryptogenic Infantile Spasms1CTD_human
HgeneHSD17B4C0393699Symptomatic Infantile Spasms1CTD_human
HgeneHSD17B4C0546878Nodding spasm1CTD_human
HgeneHSD17B4C0553558Jackknife Seizures1CTD_human
HgeneHSD17B4C0684276Hypsarrhythmia1CTD_human
HgeneHSD17B4C0751594Zellweger-Like Syndrome1CTD_human
HgeneHSD17B4C1384666hearing impairment1GENOMICS_ENGLAND
HgeneHSD17B4C1527306spasmus nutans1CTD_human
HgeneHSD17B4C1527366Salaam Seizures1CTD_human
HgeneHSD17B4C3658299Zellweger Spectrum1CTD_human
TgeneTNFAIP8C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTNFAIP8C0027627Neoplasm Metastasis1CTD_human
TgeneTNFAIP8C0087031Juvenile-Onset Still Disease1CTD_human
TgeneTNFAIP8C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTNFAIP8C3495559Juvenile arthritis1CTD_human
TgeneTNFAIP8C3714758Juvenile psoriatic arthritis1CTD_human
TgeneTNFAIP8C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneTNFAIP8C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human