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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HSPG2-VIM (FusionGDB2 ID:37875)

Fusion Gene Summary for HSPG2-VIM

check button Fusion gene summary
Fusion gene informationFusion gene name: HSPG2-VIM
Fusion gene ID: 37875
HgeneTgene
Gene symbol

HSPG2

VIM

Gene ID

3339

7431

Gene nameheparan sulfate proteoglycan 2vimentin
SynonymsHSPG|PLC|PRCAN|SJA|SJS|SJS1-
Cytomap

1p36.12

10p13

Type of geneprotein-codingprotein-coding
Descriptionbasement membrane-specific heparan sulfate proteoglycan core proteinendorepellin (domain V region)perlecan proteoglycanvimentinepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc.

VMAC

Ensembl transtripts involved in fusion geneENST00000486901, ENST00000374695, 
ENST00000430507, 		ENST00000544301, 
ENST00000224237, ENST00000485947, 
Fusion gene scores* DoF score22 X 23 X 12=607242 X 25 X 11=11550
# samples 2541
** MAII scorelog2(25/6072*10)=-4.60217179075338
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HSPG2 [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHSPG2(22204679)-VIM(17276692), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HSPG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26C-01AHSPG2chr1

22204679

-VIMchr10

17276692

+


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Fusion Gene ORF analysis for HSPG2-VIM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000486901ENST00000544301HSPG2chr1

22204679

-VIMchr10

17276692

+
intron-3CDSENST00000486901ENST00000224237HSPG2chr1

22204679

-VIMchr10

17276692

+
intron-intronENST00000486901ENST00000485947HSPG2chr1

22204679

-VIMchr10

17276692

+
In-frameENST00000374695ENST00000544301HSPG2chr1

22204679

-VIMchr10

17276692

+
In-frameENST00000374695ENST00000224237HSPG2chr1

22204679

-VIMchr10

17276692

+
5CDS-intronENST00000374695ENST00000485947HSPG2chr1

22204679

-VIMchr10

17276692

+
intron-3CDSENST00000430507ENST00000544301HSPG2chr1

22204679

-VIMchr10

17276692

+
intron-3CDSENST00000430507ENST00000224237HSPG2chr1

22204679

-VIMchr10

17276692

+
intron-intronENST00000430507ENST00000485947HSPG2chr1

22204679

-VIMchr10

17276692

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374695HSPG2chr122204679-ENST00000544301VIMchr1017276692+359827651732831088
ENST00000374695HSPG2chr122204679-ENST00000224237VIMchr1017276692+360627651732831088

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374695ENST00000544301HSPG2chr122204679-VIMchr1017276692+0.0025424140.99745756
ENST00000374695ENST00000224237HSPG2chr122204679-VIMchr1017276692+0.0025183840.99748164

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Fusion Genomic Features for HSPG2-VIM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HSPG2chr122204678-VIMchr1017276691+2.90E-050.99997103
HSPG2chr122204678-VIMchr1017276691+2.90E-050.99997103

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for HSPG2-VIM


check button Go to

FGviewer for the breakpoints of chr1:22204679-chr10:17276692

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.VIM

VMAC

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197198_235895.04392.0DomainLDL-receptor class A 1
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197284_320895.04392.0DomainLDL-receptor class A 2
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197324_360895.04392.0DomainLDL-receptor class A 3
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197367_404895.04392.0DomainLDL-receptor class A 4
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197405_504895.04392.0DomainNote=Ig-like C2-type 1
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197521_530895.04392.0DomainLaminin EGF-like 1%3B first part
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197538_730895.04392.0DomainLaminin IV type A 1
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197731_763895.04392.0DomainLaminin EGF-like 1%3B second part
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197764_813895.04392.0DomainLaminin EGF-like 2
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-219780_191895.04392.0DomainSEA
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197814_871895.04392.0DomainLaminin EGF-like 3
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739303_407294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410303_407294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739326_329294.0467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410326_329294.0467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739408_466294.0467.0RegionNote=Tail
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410408_466294.0467.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971126_1158895.04392.0DomainLaminin EGF-like 5%3B second part
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971159_1208895.04392.0DomainLaminin EGF-like 6
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971209_1265895.04392.0DomainLaminin EGF-like 7
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971275_1324895.04392.0DomainLaminin EGF-like 8
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971325_1334895.04392.0DomainLaminin EGF-like 9%3B first part
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971344_1529895.04392.0DomainLaminin IV type A 3
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971530_1562895.04392.0DomainLaminin EGF-like 9%3B second part
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971563_1612895.04392.0DomainLaminin EGF-like 10
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971613_1670895.04392.0DomainLaminin EGF-like 11
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971677_1771895.04392.0DomainNote=Ig-like C2-type 2
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971772_1865895.04392.0DomainNote=Ig-like C2-type 3
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971866_1955895.04392.0DomainNote=Ig-like C2-type 4
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21971956_2051895.04392.0DomainNote=Ig-like C2-type 5
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972052_2151895.04392.0DomainNote=Ig-like C2-type 6
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972152_2244895.04392.0DomainNote=Ig-like C2-type 7
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972245_2340895.04392.0DomainNote=Ig-like C2-type 8
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972341_2436895.04392.0DomainNote=Ig-like C2-type 9
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972437_2533895.04392.0DomainNote=Ig-like C2-type 10
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972534_2629895.04392.0DomainNote=Ig-like C2-type 11
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972630_2726895.04392.0DomainNote=Ig-like C2-type 12
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972727_2826895.04392.0DomainNote=Ig-like C2-type 13
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972827_2924895.04392.0DomainNote=Ig-like C2-type 14
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21972925_3021895.04392.0DomainNote=Ig-like C2-type 15
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973022_3112895.04392.0DomainNote=Ig-like C2-type 16
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973113_3211895.04392.0DomainNote=Ig-like C2-type 17
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973212_3298895.04392.0DomainNote=Ig-like C2-type 18
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973299_3399895.04392.0DomainNote=Ig-like C2-type 19
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973400_3488895.04392.0DomainNote=Ig-like C2-type 20
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973489_3574895.04392.0DomainNote=Ig-like C2-type 21
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973575_3662895.04392.0DomainNote=Ig-like C2-type 22
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973663_3843895.04392.0DomainLaminin G-like 1
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973844_3881895.04392.0DomainEGF-like 1
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973884_3922895.04392.0DomainEGF-like 2
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21973928_4103895.04392.0DomainLaminin G-like 2
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21974104_4141895.04392.0DomainEGF-like 3
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21974143_4176895.04392.0DomainEGF-like 4
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21974201_4389895.04392.0DomainLaminin G-like 3
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197879_923895.04392.0DomainLaminin EGF-like 4%3B truncated
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197924_933895.04392.0DomainLaminin EGF-like 5%3B first part
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-2197941_1125895.04392.0DomainLaminin IV type A 2
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21974149_4151895.04392.0RegionMediates motor neuron attachment
HgeneHSPG2chr1:22204679chr10:17276692ENST00000374695-21974299_4301895.04392.0RegionMediates motor neuron attachment
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739154_245294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr1:22204679chr10:17276692ENST000002242373996_131294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410154_245294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr1:22204679chr10:17276692ENST0000054430141096_131294.0467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739103_411294.0467.0DomainIF rod
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410103_411294.0467.0DomainIF rod
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739132_153294.0467.0RegionNote=Linker 1
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739246_268294.0467.0RegionNote=Linker 12
TgeneVIMchr1:22204679chr10:17276692ENST0000022423739269_407294.0467.0RegionNote=Coil 2
TgeneVIMchr1:22204679chr10:17276692ENST00000224237392_95294.0467.0RegionNote=Head
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410132_153294.0467.0RegionNote=Linker 1
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410246_268294.0467.0RegionNote=Linker 12
TgeneVIMchr1:22204679chr10:17276692ENST00000544301410269_407294.0467.0RegionNote=Coil 2
TgeneVIMchr1:22204679chr10:17276692ENST000005443014102_95294.0467.0RegionNote=Head


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Fusion Gene Sequence for HSPG2-VIM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000374695_ENST00000544301_TCGA-GN-A26C-01A_HSPG2_chr1_22204679_-_VIM_chr10_17276692_length(transcript)=3598nt_BP=2765nt
GGCCGGCGAGCGGGCGGCTGCGGGCGGCGCGGAGCGGGCGGCGCGGAGCGAGCGAGCGAGAGAGCGGCGCGGGCCGGGCCATGGGGTGGC
GGGCGGCGGGCGCGCTGCTGCTGGCGCTGCTGCTGCACGGGCGGCTGCTGGCGGTGACCCATGGGCTGAGGGCATACGATGGCTTGTCTC
TGCCTGAGGACATAGAGACCGTCACAGCAAGCCAAATGCGCTGGACACATTCGTACCTTTCTGATGATGAGGACATGCTGGCTGACAGCA
TCTCAGGAGACGACCTGGGCAGTGGGGACCTGGGCAGCGGGGACTTCCAGATGGTTTATTTCCGAGCCCTGGTGAATTTCACTCGCTCCA
TCGAGTACAGCCCTCAGCTGGAGGATGCAGGCTCCAGAGAGTTCCGAGAGGTGTCCGAGGCTGTGGTAGACACGCTGGAGTCGGAGTACT
TGAAAATTCCCGGAGACCAGGTTGTCAGTGTGGTGTTCATCAAGGAGCTGGATGGCTGGGTTTTTGTGGAGCTGGATGTGGGCTCGGAAG
GGAATGCGGATGGGGCTCAGATTCAGGAGATGCTGCTCAGGGTCATCTCCAGCGGCTCTGTGGCCTCCTACGTCACCTCTCCCCAGGGAT
TCCAGTTCCGACGCCTGGGCACAGTGCCCCAGTTCCCAAGAGCCTGCACGGAGGCCGAGTTTGCCTGCCACAGCTACAATGAGTGTGTGG
CCCTGGAGTATCGCTGTGACCGGCGGCCCGACTGCAGGGACATGTCTGATGAGCTCAATTGTGAGGAGCCAGTCCTGGGTATCAGCCCCA
CATTCTCTCTCCTTGTGGAGACGACATCTTTACCGCCCCGGCCAGAGACAACCATCATGCGACAGCCACCAGTCACCCACGCTCCTCAGC
CCCTGCTTCCCGGTTCCGTCAGGCCCCTGCCCTGTGGGCCCCAGGAGGCCGCATGCCGCAATGGGCACTGCATCCCCAGAGACTACCTCT
GCGACGGACAGGAGGACTGCGAGGACGGCAGCGATGAGCTAGACTGTGGCCCCCCGCCACCCTGTGAGCCCAACGAGTTCCCCTGCGGGA
ATGGACATTGTGCCCTCAAGCTGTGGCGCTGCGATGGTGACTTTGACTGTGAGGACCGAACTGATGAAGCCAACTGCCCCACCAAGCGTC
CTGAGGAAGTGTGCGGGCCCACACAGTTCCGATGCGTCTCTACCAACATGTGCATCCCAGCCAGCTTCCACTGTGACGAGGAGAGCGACT
GTCCTGACCGGAGCGACGAGTTTGGCTGCATGCCCCCCCAGGTGGTGACACCTCCCCGGGAGTCCATCCAGGCTTCCCGGGGCCAGACAG
TGACCTTCACCTGCGTGGCCATTGGCGTCCCCACCCCCATCATCAATTGGAGGCTCAACTGGGGCCACATCCCCTCTCATCCCAGGGTGA
CAGTGACCAGCGAGGGTGGCCGTGGCACACTGATCATCCGTGATGTGAAGGAGTCAGACCAGGGTGCCTACACCTGTGAGGCCATGAACG
CCCGGGGCATGGTGTTTGGCATTCCTGACGGTGTCCTTGAGCTCGTCCCACAACGAGGCCCCTGCCCTGACGGCCACTTCTACCTGGAGC
ACAGCGCCGCCTGCCTGCCCTGCTTCTGCTTTGGCATCACCAGCGTGTGCCAGAGCACCCGCCGCTTCCGGGACCAGATCAGGCTGCGCT
TTGACCAACCCGATGACTTCAAGGGTGTGAATGTGACAATGCCTGCGCAGCCCGGCACGCCACCCCTCTCCTCCACGCAGCTGCAGATCG
ACCCATCCCTGCACGAGTTCCAGCTAGTCGACCTGTCCCGCCGCTTCCTCGTCCACGACTCCTTCTGGGCTCTGCCTGAACAGTTCCTGG
GCAACAAGGTGGACTCCTATGGCGGCTCCCTGCGTTACAACGTGCGCTACGAGTTGGCCCGTGGCATGCTGGAGCCAGTGCAGCGGCCGG
ACGTGGTCCTCATGGGTGCCGGGTACCGCCTCCTCTCCCGAGGCCACACACCCACCCAACCTGGTGCTCTGAACCAGCGCCAGGTCCAGT
TCTCTGAGGAGCACTGGGTCCATGAGTCTGGCCGGCCGGTGCAGCGCGCGGAGCTGCTGCAGGTGCTGCAGAGCCTGGAGGCCGTGCTCA
TCCAGACCGTGTACAACACCAAGATGGCCAGCGTGGGACTTAGCGACATCGCCATGGATACCACCGTCACCCATGCCACCAGCCATGGCC
GTGCCCACAGTGTGGAGGAGTGCAGATGCCCCATTGGCTATTCTGGCTTGTCCTGCGAGAGCTGTGATGCCCACTTCACTCGGGTGCCTG
GTGGGCCCTACCTGGGCACCTGCTCTGGTTGCAATTGCAATGGCCATGCCAGCTCCTGTGACCCTGTGTATGGCCACTGCCTGAATTGCC
AGCACAACACGGAGGGGCCACAGTGCAACAAGTGCAAGGCTGGCTTCTTTGGGGACGCCATGAAGGCCACGGCCACTTCCTGCCGGCCCT
GCCCTTGCCCATACATCGATGCCTCCCGCAGATTCTCAGACACTTGCTTCCTGGACACGGATGGCCAAGCCACATGTGACGCCTGTGCCC
CAGGCTACACTGGCCGCCGCTGTGAGAGCTGTGCCCCCGGATACGAGGGCAACCCCATCCAGCCCGGCGGGAAGTGCAGGCCCGTCAACC
AGGAGATTGTGCGCTGTGACGAGCGTGGCAGCATGGGGACCTCCGGGGAGGCCTGCCGCTGTAAGTTTGCTGACCTCTCTGAGGCTGCCA
ACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCC
TTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTG
GCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCC
TTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACC
TGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGAC
AGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAA
AAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTC
TAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTT

>In-frame_ENST00000374695_ENST00000544301_TCGA-GN-A26C-01A_HSPG2_chr1_22204679_-_VIM_chr10_17276692_length(amino acids)=1088AA_start in transcript=17_stop in transcript=3283
MRAARSGRRGASERESGAGRAMGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDMLADSISGDDL
GSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGA
QIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLV
ETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCAL
KLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCV
AIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACL
PCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDS
YGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYN
TKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG
PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRC
DERGSMGTSGEACRCKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDE
IQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINET

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>In-frame_ENST00000374695_ENST00000224237_TCGA-GN-A26C-01A_HSPG2_chr1_22204679_-_VIM_chr10_17276692_length(transcript)=3606nt_BP=2765nt
GGCCGGCGAGCGGGCGGCTGCGGGCGGCGCGGAGCGGGCGGCGCGGAGCGAGCGAGCGAGAGAGCGGCGCGGGCCGGGCCATGGGGTGGC
GGGCGGCGGGCGCGCTGCTGCTGGCGCTGCTGCTGCACGGGCGGCTGCTGGCGGTGACCCATGGGCTGAGGGCATACGATGGCTTGTCTC
TGCCTGAGGACATAGAGACCGTCACAGCAAGCCAAATGCGCTGGACACATTCGTACCTTTCTGATGATGAGGACATGCTGGCTGACAGCA
TCTCAGGAGACGACCTGGGCAGTGGGGACCTGGGCAGCGGGGACTTCCAGATGGTTTATTTCCGAGCCCTGGTGAATTTCACTCGCTCCA
TCGAGTACAGCCCTCAGCTGGAGGATGCAGGCTCCAGAGAGTTCCGAGAGGTGTCCGAGGCTGTGGTAGACACGCTGGAGTCGGAGTACT
TGAAAATTCCCGGAGACCAGGTTGTCAGTGTGGTGTTCATCAAGGAGCTGGATGGCTGGGTTTTTGTGGAGCTGGATGTGGGCTCGGAAG
GGAATGCGGATGGGGCTCAGATTCAGGAGATGCTGCTCAGGGTCATCTCCAGCGGCTCTGTGGCCTCCTACGTCACCTCTCCCCAGGGAT
TCCAGTTCCGACGCCTGGGCACAGTGCCCCAGTTCCCAAGAGCCTGCACGGAGGCCGAGTTTGCCTGCCACAGCTACAATGAGTGTGTGG
CCCTGGAGTATCGCTGTGACCGGCGGCCCGACTGCAGGGACATGTCTGATGAGCTCAATTGTGAGGAGCCAGTCCTGGGTATCAGCCCCA
CATTCTCTCTCCTTGTGGAGACGACATCTTTACCGCCCCGGCCAGAGACAACCATCATGCGACAGCCACCAGTCACCCACGCTCCTCAGC
CCCTGCTTCCCGGTTCCGTCAGGCCCCTGCCCTGTGGGCCCCAGGAGGCCGCATGCCGCAATGGGCACTGCATCCCCAGAGACTACCTCT
GCGACGGACAGGAGGACTGCGAGGACGGCAGCGATGAGCTAGACTGTGGCCCCCCGCCACCCTGTGAGCCCAACGAGTTCCCCTGCGGGA
ATGGACATTGTGCCCTCAAGCTGTGGCGCTGCGATGGTGACTTTGACTGTGAGGACCGAACTGATGAAGCCAACTGCCCCACCAAGCGTC
CTGAGGAAGTGTGCGGGCCCACACAGTTCCGATGCGTCTCTACCAACATGTGCATCCCAGCCAGCTTCCACTGTGACGAGGAGAGCGACT
GTCCTGACCGGAGCGACGAGTTTGGCTGCATGCCCCCCCAGGTGGTGACACCTCCCCGGGAGTCCATCCAGGCTTCCCGGGGCCAGACAG
TGACCTTCACCTGCGTGGCCATTGGCGTCCCCACCCCCATCATCAATTGGAGGCTCAACTGGGGCCACATCCCCTCTCATCCCAGGGTGA
CAGTGACCAGCGAGGGTGGCCGTGGCACACTGATCATCCGTGATGTGAAGGAGTCAGACCAGGGTGCCTACACCTGTGAGGCCATGAACG
CCCGGGGCATGGTGTTTGGCATTCCTGACGGTGTCCTTGAGCTCGTCCCACAACGAGGCCCCTGCCCTGACGGCCACTTCTACCTGGAGC
ACAGCGCCGCCTGCCTGCCCTGCTTCTGCTTTGGCATCACCAGCGTGTGCCAGAGCACCCGCCGCTTCCGGGACCAGATCAGGCTGCGCT
TTGACCAACCCGATGACTTCAAGGGTGTGAATGTGACAATGCCTGCGCAGCCCGGCACGCCACCCCTCTCCTCCACGCAGCTGCAGATCG
ACCCATCCCTGCACGAGTTCCAGCTAGTCGACCTGTCCCGCCGCTTCCTCGTCCACGACTCCTTCTGGGCTCTGCCTGAACAGTTCCTGG
GCAACAAGGTGGACTCCTATGGCGGCTCCCTGCGTTACAACGTGCGCTACGAGTTGGCCCGTGGCATGCTGGAGCCAGTGCAGCGGCCGG
ACGTGGTCCTCATGGGTGCCGGGTACCGCCTCCTCTCCCGAGGCCACACACCCACCCAACCTGGTGCTCTGAACCAGCGCCAGGTCCAGT
TCTCTGAGGAGCACTGGGTCCATGAGTCTGGCCGGCCGGTGCAGCGCGCGGAGCTGCTGCAGGTGCTGCAGAGCCTGGAGGCCGTGCTCA
TCCAGACCGTGTACAACACCAAGATGGCCAGCGTGGGACTTAGCGACATCGCCATGGATACCACCGTCACCCATGCCACCAGCCATGGCC
GTGCCCACAGTGTGGAGGAGTGCAGATGCCCCATTGGCTATTCTGGCTTGTCCTGCGAGAGCTGTGATGCCCACTTCACTCGGGTGCCTG
GTGGGCCCTACCTGGGCACCTGCTCTGGTTGCAATTGCAATGGCCATGCCAGCTCCTGTGACCCTGTGTATGGCCACTGCCTGAATTGCC
AGCACAACACGGAGGGGCCACAGTGCAACAAGTGCAAGGCTGGCTTCTTTGGGGACGCCATGAAGGCCACGGCCACTTCCTGCCGGCCCT
GCCCTTGCCCATACATCGATGCCTCCCGCAGATTCTCAGACACTTGCTTCCTGGACACGGATGGCCAAGCCACATGTGACGCCTGTGCCC
CAGGCTACACTGGCCGCCGCTGTGAGAGCTGTGCCCCCGGATACGAGGGCAACCCCATCCAGCCCGGCGGGAAGTGCAGGCCCGTCAACC
AGGAGATTGTGCGCTGTGACGAGCGTGGCAGCATGGGGACCTCCGGGGAGGCCTGCCGCTGTAAGTTTGCTGACCTCTCTGAGGCTGCCA
ACCGGAACAATGACGCCCTGCGCCAGGCAAAGCAGGAGTCCACTGAGTACCGGAGACAGGTGCAGTCCCTCACCTGTGAAGTGGATGCCC
TTAAAGGAACCAATGAGTCCCTGGAACGCCAGATGCGTGAAATGGAAGAGAACTTTGCCGTTGAAGCTGCTAACTACCAAGACACTATTG
GCCGCCTGCAGGATGAGATTCAGAATATGAAGGAGGAAATGGCTCGTCACCTTCGTGAATACCAAGACCTGCTCAATGTTAAGATGGCCC
TTGACATTGAGATTGCCACCTACAGGAAGCTGCTGGAAGGCGAGGAGAGCAGGATTTCTCTGCCTCTTCCAAACTTTTCCTCCCTGAACC
TGAGGGAAACTAATCTGGATTCACTCCCTCTGGTTGATACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGAC
AGGTTATCAACGAAACTTCTCAGCATCACGATGACCTTGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAA
AAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTGCCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTC
TAGTTCTTAACAACCGACACTCCTACAAGATTTAGAAAAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTT
TTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTTTTTTTCCAGCAAGTATCCAACCAACTTGGTTCTGCTTCAATAAATCTTTGGAA

>In-frame_ENST00000374695_ENST00000224237_TCGA-GN-A26C-01A_HSPG2_chr1_22204679_-_VIM_chr10_17276692_length(amino acids)=1088AA_start in transcript=17_stop in transcript=3283
MRAARSGRRGASERESGAGRAMGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDMLADSISGDDL
GSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGA
QIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLV
ETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCAL
KLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCV
AIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACL
PCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDS
YGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYN
TKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG
PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRC
DERGSMGTSGEACRCKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDE
IQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINET

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Fusion Gene PPI Analysis for HSPG2-VIM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HSPG2-VIM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HSPG2-VIM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHSPG2C0036391Schwartz-Jampel Syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHSPG2C4551479Schwartz-Jampel Syndrome, Type 13CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHSPG2C0013366Dyschondroplasias2CTD_human
HgeneHSPG2C0025237Melnick-Needles Syndrome2CTD_human
HgeneHSPG2C0026760Multiple Epiphyseal Dysplasia2CTD_human
HgeneHSPG2C0029422Osteochondrodysplasias2CTD_human
HgeneHSPG2C0038015Spondyloepiphyseal Dysplasia2CTD_human
HgeneHSPG2C0432272Van Buchem disease2CTD_human
HgeneHSPG2C3541456Spondyloepiphyseal Dysplasia Tarda, X-Linked2CTD_human
HgeneHSPG2C0004238Atrial Fibrillation1CTD_human
HgeneHSPG2C0235480Paroxysmal atrial fibrillation1CTD_human
HgeneHSPG2C0376634Craniofacial Abnormalities1CTD_human
HgeneHSPG2C1857100Dyssegmental dysplasia1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneHSPG2C2585653Persistent atrial fibrillation1CTD_human
HgeneHSPG2C3468561familial atrial fibrillation1CTD_human
TgeneVIMC0006142Malignant neoplasm of breast4CTD_human
TgeneVIMC0678222Breast Carcinoma4CTD_human
TgeneVIMC1257931Mammary Neoplasms, Human4CTD_human
TgeneVIMC1458155Mammary Neoplasms4CTD_human
TgeneVIMC3805411CATARACT 304GENOMICS_ENGLAND;UNIPROT
TgeneVIMC4704874Mammary Carcinoma, Human4CTD_human
TgeneVIMC0023890Liver Cirrhosis2CTD_human
TgeneVIMC0029408Degenerative polyarthritis2CTD_human
TgeneVIMC0033578Prostatic Neoplasms2CTD_human
TgeneVIMC0086743Osteoarthrosis Deformans2CTD_human
TgeneVIMC0239946Fibrosis, Liver2CTD_human
TgeneVIMC0376358Malignant neoplasm of prostate2CTD_human
TgeneVIMC0007140Carcinosarcoma1CTD_human
TgeneVIMC0007621Neoplastic Cell Transformation1CTD_human
TgeneVIMC0019193Hepatitis, Toxic1CTD_human
TgeneVIMC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneVIMC0027626Neoplasm Invasiveness1CTD_human
TgeneVIMC0027627Neoplasm Metastasis1CTD_human
TgeneVIMC0027720Nephrosis1CTD_human
TgeneVIMC0031149Peritoneal Neoplasms1CTD_human
TgeneVIMC0035126Reperfusion Injury1CTD_human
TgeneVIMC0035309Retinal Diseases1CTD_human
TgeneVIMC0039101synovial sarcoma1CTD_human
TgeneVIMC0043094Weight Gain1CTD_human
TgeneVIMC0085084Motor Neuron Disease1CTD_human
TgeneVIMC0086543Cataract1CTD_human
TgeneVIMC0154681Anterior Horn Cell Disease1CTD_human
TgeneVIMC0154682Lateral Sclerosis1CTD_human
TgeneVIMC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneVIMC0270763Familial Motor Neuron Disease1CTD_human
TgeneVIMC0270764Motor Neuron Disease, Lower1CTD_human
TgeneVIMC0345967Malignant mesothelioma1CTD_human
TgeneVIMC0346990Carcinomatosis of peritoneal cavity1CTD_human
TgeneVIMC0521659Motor Neuron Disease, Upper1CTD_human
TgeneVIMC0524524Pseudoaphakia1CTD_human
TgeneVIMC0524851Neurodegenerative Disorders1CTD_human
TgeneVIMC0543858Motor Neuron Disease, Secondary1CTD_human
TgeneVIMC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneVIMC0860207Drug-Induced Liver Disease1CTD_human
TgeneVIMC0948089Acute Coronary Syndrome1CTD_human
TgeneVIMC1262760Hepatitis, Drug-Induced1CTD_human
TgeneVIMC1510497Lens Opacities1CTD_human
TgeneVIMC1833118Cataract, Pulverulent1ORPHANET
TgeneVIMC1852438CATARACT, COPPOCK-LIKE1ORPHANET
TgeneVIMC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneVIMC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneVIMC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneVIMC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneVIMC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneVIMC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human