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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ABCC3-BCAN (FusionGDB2 ID:380) |
Fusion Gene Summary for ABCC3-BCAN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ABCC3-BCAN | Fusion gene ID: 380 | Hgene | Tgene | Gene symbol | ABCC3 | BCAN | Gene ID | 8714 | 63827 |
| Gene name | ATP binding cassette subfamily C member 3 | brevican | |
| Synonyms | ABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2 | BEHAB|CSPG7 | |
| Cytomap | 17q21.33 | 1q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | canalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrug | brevican core proteinbrain-enriched hyaluronan-binding proteinchondroitin sulfate proteoglycan 7chondroitin sulfate proteoglycan BEHAB | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O15438 | Q96GW7 | |
| Ensembl transtripts involved in fusion gene | ENST00000285238, ENST00000515707, ENST00000427699, ENST00000510891, | ENST00000329117, ENST00000361588, | |
| Fusion gene scores | * DoF score | 16 X 12 X 7=1344 | 3 X 1 X 2=6 |
| # samples | 18 | 3 | |
| ** MAII score | log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
| Context | PubMed: ABCC3 [Title/Abstract] AND BCAN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ABCC3(48751019)-BCAN(156627467), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABCC3 | GO:0042908 | xenobiotic transport | 18698235|19334674 |
| Fusion gene breakpoints across ABCC3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across BCAN (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-CW-5584-01A | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| ChimerDB4 | KIRC | TCGA-CW-5584-01A | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| ChimerDB4 | KIRC | TCGA-CW-5584-01A | ABCC3 | chr17 | 48751019 | - | BCAN | chr1 | 156627467 | + |
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Fusion Gene ORF analysis for ABCC3-BCAN |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000285238 | ENST00000329117 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| 5CDS-intron | ENST00000285238 | ENST00000361588 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| intron-3CDS | ENST00000515707 | ENST00000329117 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| intron-intron | ENST00000515707 | ENST00000361588 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| intron-3CDS | ENST00000427699 | ENST00000329117 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| intron-intron | ENST00000427699 | ENST00000361588 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| intron-3CDS | ENST00000510891 | ENST00000329117 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| intron-intron | ENST00000510891 | ENST00000361588 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000285238 | ABCC3 | chr17 | 48751019 | + | ENST00000329117 | BCAN | chr1 | 156627467 | + | 3600 | 2679 | 59 | 3205 | 1048 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000285238 | ENST00000329117 | ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627467 | + | 0.001994935 | 0.9980051 |
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Fusion Genomic Features for ABCC3-BCAN |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627466 | + | 0.004041239 | 0.99595875 |
| ABCC3 | chr17 | 48751019 | + | BCAN | chr1 | 156627466 | + | 0.004041239 | 0.99595875 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ABCC3-BCAN |
| Go to FGviewer for the breakpoints of chr17:48751019-chr1:156627467 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABCC3 | BCAN |
| FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}. | FUNCTION: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 311_594 | 866.3333333333334 | 1528.0 | Domain | ABC transmembrane type-1 1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 629_851 | 866.3333333333334 | 1528.0 | Domain | ABC transporter 1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 661_668 | 866.3333333333334 | 1528.0 | Nucleotide binding | ATP 1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 121_132 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 154_171 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 193_302 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1_32 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 324_349 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 371_426 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 448_450 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 472_533 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 54_73 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 555_576 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 95_99 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 100_120 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D3 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 133_153 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D4 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 172_192 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D5 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 303_323 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D6 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 33_53 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 350_370 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D7 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 427_447 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D8 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 451_471 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D9 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 534_554 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D10 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 577_597 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D11 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 74_94 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D2 |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 385_477 | 0 | 672.0 | Compositional bias | Note=Glu-rich | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 813_873 | 736.3333333333334 | 912.0 | Domain | Sushi | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 157_252 | 0 | 672.0 | Domain | Link 1 | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 257_354 | 0 | 672.0 | Domain | Link 2 | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 36_155 | 0 | 672.0 | Domain | Note=Ig-like V-type | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 646_682 | 0 | 672.0 | Domain | EGF-like | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 695_809 | 0 | 672.0 | Domain | C-type lectin | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 813_873 | 0 | 672.0 | Domain | Sushi | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 520_530 | 0 | 672.0 | Region | Note=O-glycosylated at two sites | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 540_545 | 0 | 672.0 | Region | Note=O-glycosylated at two sites | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000361588 | 0 | 8 | 569_575 | 0 | 672.0 | Region | Note=O-glycosylated at one site |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1291_1523 | 866.3333333333334 | 1528.0 | Domain | ABC transporter 2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 971_1252 | 866.3333333333334 | 1528.0 | Domain | ABC transmembrane type-1 2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1291_1523 | 0 | 573.0 | Domain | ABC transporter 2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 311_594 | 0 | 573.0 | Domain | ABC transmembrane type-1 1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 629_851 | 0 | 573.0 | Domain | ABC transporter 1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 971_1252 | 0 | 573.0 | Domain | ABC transmembrane type-1 2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1323_1330 | 866.3333333333334 | 1528.0 | Nucleotide binding | ATP 2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1323_1330 | 0 | 573.0 | Nucleotide binding | ATP 2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 661_668 | 0 | 573.0 | Nucleotide binding | ATP 1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1043_1085 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1107_1107 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1129_1199 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1221_1222 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1244_1527 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 598_963 | 866.3333333333334 | 1528.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 985_1021 | 866.3333333333334 | 1528.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1043_1085 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1107_1107 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1129_1199 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 121_132 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1221_1222 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1244_1527 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 154_171 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 193_302 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1_32 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 324_349 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 371_426 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 448_450 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 472_533 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 54_73 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 555_576 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 598_963 | 0 | 573.0 | Topological domain | Cytoplasmic |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 95_99 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 985_1021 | 0 | 573.0 | Topological domain | Extracellular |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1022_1042 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D13 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1086_1106 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D14 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1108_1128 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D15 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1200_1220 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D16 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 1223_1243 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D17 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000285238 | + | 19 | 31 | 964_984 | 866.3333333333334 | 1528.0 | Transmembrane | Helical%3B Name%3D12 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 100_120 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D3 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1022_1042 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D13 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1086_1106 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D14 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1108_1128 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D15 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1200_1220 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D16 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 1223_1243 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D17 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 133_153 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D4 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 172_192 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D5 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 303_323 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D6 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 33_53 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D1 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 350_370 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D7 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 427_447 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D8 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 451_471 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D9 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 534_554 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D10 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 577_597 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D11 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 74_94 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D2 |
| Hgene | ABCC3 | chr17:48751019 | chr1:156627467 | ENST00000427699 | + | 1 | 12 | 964_984 | 0 | 573.0 | Transmembrane | Helical%3B Name%3D12 |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 385_477 | 736.3333333333334 | 912.0 | Compositional bias | Note=Glu-rich | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 157_252 | 736.3333333333334 | 912.0 | Domain | Link 1 | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 257_354 | 736.3333333333334 | 912.0 | Domain | Link 2 | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 36_155 | 736.3333333333334 | 912.0 | Domain | Note=Ig-like V-type | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 646_682 | 736.3333333333334 | 912.0 | Domain | EGF-like | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 695_809 | 736.3333333333334 | 912.0 | Domain | C-type lectin | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 520_530 | 736.3333333333334 | 912.0 | Region | Note=O-glycosylated at two sites | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 540_545 | 736.3333333333334 | 912.0 | Region | Note=O-glycosylated at two sites | |
| Tgene | BCAN | chr17:48751019 | chr1:156627467 | ENST00000329117 | 9 | 14 | 569_575 | 736.3333333333334 | 912.0 | Region | Note=O-glycosylated at one site |
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Fusion Gene Sequence for ABCC3-BCAN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000285238_ENST00000329117_TCGA-CW-5584-01A_ABCC3_chr17_48751019_+_BCAN_chr1_156627467_length(transcript)=3600nt_BP=2679nt GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCTGTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGA ACTCCCTGCTGGCCTGGGTGCCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGTCGTGGCTACA TCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTGTGGTGCGTCTCCTGGGCGGACCTTTTTTACTCCTTCCATG GCCTGGTCCATGGCCGGGCCCCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACCCTGCTGATAC AGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTCTGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCT CCAAGATCCTTTTAGCCAAGGCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTGGTACTCTCTG CCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAGAATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCT TTCTCTCCCGCCTGTTTTTCTGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTCTGGTCCCTAA AGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGGAGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAG CAGCACCTGGGAAAAATGCCTCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTGAAGGCCCTGC TGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATCCAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCA TCCTGATCAGGTTTATCTCCAACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCCATGATGCAGT CGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAGTTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTC TGGTTATCACCAACTCAGTCAAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTCATGGACCTTG CCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCGATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGG CTGGAGTCGCTTTCATGGTCTTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAAATGAAATTGA AGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTGCTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGG TGGAGGGCATCAGGCAGGGTGAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATGTGCAGCCCCT TCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAACAATGTGCTGGACGCCGAGAAGGCCTTTGTGTCTGTGTCCT TGTTTAATATCTTAAGACTTCCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAACGGATCCAGC AATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACCATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCT TCACCTGGGCCCAGGACCTGCCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTGGGGCCTGTGG GCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAGCTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATG TGCCCCAGCAGGCATGGATCCAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTACCAGCAGACTC TGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGATCAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGG GCCAGCGGCAGCGGGTCAGTCTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCGGTGGACTCTC ATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTGGCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCT TCCTGCCCCAGACAGACTTCATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAGCGCAACGGCT CCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCACCTGGAGGACAGCTGGACCGACCGGTACCGGGAGTACCAGT GGATCGGACTCAACGACAGGACCATCGAAGGCGACTTCTTGTGGTCGGATGGCGTCCCCCTGCTCTATGAGAACTGGAACCCTGGGCAGC CTGACAGCTACTTCCTGTCTGGAGAGAACTGCGTGGTCATGGTGTGGCATGATCAGGGACAATGGAGTGACGTGCCCTGCAACTACCACC TGTCCTACACCTGCAAGATGGGGCTGGTGTCCTGTGGGCCGCCACCGGAGCTGCCCCTGGCTCAAGTGTTCGGCCGCCCACGGCTGCGCT ATGAGGTGGACACTGTGCTTCGCTACCGGTGCCGGGAAGGACTGGCCCAGCGCAATCTGCCGCTGATCCGATGCCAAGAGAACGGTCGTT GGGAGGCCCCCCAGATCTCCTGTGTGCCCAGAAGACCTGCCCGAGCTCTGCACCCAGAGGAGGACCCAGAAGGACGTCAGGGGAGGCTAC TGGGACGCTGGAAGGCGCTGTTGATCCCCCCTTCCAGCCCCATGCCAGGTCCCTAGGGGGCAAGGCCTTGAACACTGCCGGCCACAGCAC TGCCCTGTCACCCAAATTTTCCCTCACACCCTGCGCTCCCGCCACCACAGGAAGTGACAACATGACGAGGGGTGGTACTGGAGTCCAGGT GACAGTTCCTGAAGGGGCTTCTGGGAAATACCTAGGAGGCTCCAGCCCAGCCCAGGCCCTCTCCCCCTACCCTGGGCACCAGATCTTCCA TCAGGGCCGGAGTAAATCCCTAAGTGCCTCAACTGCCCTCTCCCTGGCAGCCATCTTGTCCCCTCTATTCCTCTAGGGAGCACTGTGCCC ACTCTTTCTGGGTTTTCCAAGGGAATGGGCTTGCAGGATGGAGTGTCTGTAAAATCAACAGGAAATAAAACTGTGTATGAGCCCAGGCAA >In-frame_ENST00000285238_ENST00000329117_TCGA-CW-5584-01A_ABCC3_chr17_48751019_+_BCAN_chr1_156627467_length(amino acids)=1048AA_start in transcript=59_stop in transcript=3205 MQPRLGPMDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCV SWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTT FYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYF LWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISP GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGK ALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGK TRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTDRYREYQWIGLNDRTIEGDFLWSDGVP LLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ABCC3-BCAN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABCC3-BCAN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABCC3-BCAN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ABCC3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Hgene | ABCC3 | C0008370 | Cholestasis | 1 | CTD_human |
| Hgene | ABCC3 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Hgene | ABCC3 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | ABCC3 | C0019209 | Hepatomegaly | 1 | CTD_human |
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