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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ICAM1-FDX1L (FusionGDB2 ID:38027)

Fusion Gene Summary for ICAM1-FDX1L

check button Fusion gene summary
Fusion gene informationFusion gene name: ICAM1-FDX1L
Fusion gene ID: 38027
HgeneTgene
Gene symbol

ICAM1

FDX1L

Gene ID

3383

112812

Gene nameintercellular adhesion molecule 1ferredoxin 2
SynonymsBB2|CD54|P3.58FDX1L|MEOAL
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionintercellular adhesion molecule 1ICAM-1cell surface glycoprotein P3.58epididymis secretory sperm binding proteinintercellular adhesion molecule 1 (CD54), human rhinovirus receptormajor group rhinovirus receptorferredoxin-2, mitochondrialadrenodoxin-like protein, mitochondrialferredoxin 1 like
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264832, ENST00000423829, 
ENST00000585443, 		ENST00000541276, 
ENST00000393708, ENST00000492239, 
ENST00000494368, 
Fusion gene scores* DoF score8 X 6 X 5=2406 X 3 X 5=90
# samples 97
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ICAM1 [Title/Abstract] AND FDX1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointICAM1(10381902)-FDX1L(10421616), # samples:1
Anticipated loss of major functional domain due to fusion event.ICAM1-FDX1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneICAM1

GO:0007155

cell adhesion

16809613

HgeneICAM1

GO:0044406

adhesion of symbiont to host

2538243

HgeneICAM1

GO:0046813

receptor-mediated virion attachment to host cell

2538243

HgeneICAM1

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

HgeneICAM1

GO:1904646

cellular response to amyloid-beta

11078691

HgeneICAM1

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check buttonFusion gene breakpoints across ICAM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FDX1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1EVICAM1chr19

10381902

+FDX1Lchr19

10421616

-


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Fusion Gene ORF analysis for ICAM1-FDX1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264832ENST00000541276ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
In-frameENST00000264832ENST00000393708ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
5CDS-5UTRENST00000264832ENST00000492239ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
5CDS-5UTRENST00000264832ENST00000494368ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
Frame-shiftENST00000423829ENST00000541276ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
In-frameENST00000423829ENST00000393708ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
5CDS-5UTRENST00000423829ENST00000492239ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
5CDS-5UTRENST00000423829ENST00000494368ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
intron-3CDSENST00000585443ENST00000541276ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
intron-3CDSENST00000585443ENST00000393708ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
intron-5UTRENST00000585443ENST00000492239ICAM1chr19

10381902

+FDX1Lchr19

10421616

-
intron-5UTRENST00000585443ENST00000494368ICAM1chr19

10381902

+FDX1Lchr19

10421616

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ICAM1-FDX1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ICAM1-FDX1L


check button Go to

FGviewer for the breakpoints of chr19:10381902-chr19:10421616

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17128_19322.333333333333332533.0DomainNote=Ig-like C2-type 2
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17230_29722.333333333333332533.0DomainNote=Ig-like C2-type 3
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17325_37822.333333333333332533.0DomainNote=Ig-like C2-type 4
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17412_46422.333333333333332533.0DomainNote=Ig-like C2-type 5
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+1741_10322.333333333333332533.0DomainNote=Ig-like C2-type 1
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17152_15422.333333333333332533.0MotifCell attachment site%3B atypical
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+1728_48022.333333333333332533.0Topological domainExtracellular
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17504_53222.333333333333332533.0Topological domainCytoplasmic
HgeneICAM1chr19:10381902chr19:10421616ENST00000264832+17481_50322.333333333333332533.0TransmembraneHelical
TgeneFDX1Lchr19:10381902chr19:10421616ENST000003937082571_173102.33333333333333184.0Domain2Fe-2S ferredoxin-type


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Fusion Gene Sequence for ICAM1-FDX1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ICAM1-FDX1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ICAM1-FDX1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ICAM1-FDX1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneICAM1C0002152Alloxan Diabetes3CTD_human
HgeneICAM1C0011853Diabetes Mellitus, Experimental3CTD_human
HgeneICAM1C0038433Streptozotocin Diabetes3CTD_human
HgeneICAM1C0004096Asthma2CTD_human
HgeneICAM1C0004943Behcet Syndrome2CTD_human
HgeneICAM1C0007102Malignant tumor of colon2CTD_human
HgeneICAM1C0007222Cardiovascular Diseases2CTD_human
HgeneICAM1C0007786Brain Ischemia2CTD_human
HgeneICAM1C0009375Colonic Neoplasms2CTD_human
HgeneICAM1C0019284Diaphragmatic Hernia2CTD_human
HgeneICAM1C0020538Hypertensive disease2CTD_human
HgeneICAM1C0021368Inflammation2CTD_human
HgeneICAM1C0035126Reperfusion Injury2CTD_human
HgeneICAM1C0242488Acute Lung Injury2CTD_human
HgeneICAM1C0917798Cerebral Ischemia2CTD_human
HgeneICAM1C0004153Atherosclerosis1CTD_human
HgeneICAM1C0006267Bronchiectasis1CTD_human
HgeneICAM1C0008370Cholestasis1CTD_human
HgeneICAM1C0009324Ulcerative Colitis1CTD_human
HgeneICAM1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneICAM1C0011884Diabetic Retinopathy1CTD_human
HgeneICAM1C0020443Hypercholesterolemia1CTD_human
HgeneICAM1C0021390Inflammatory Bowel Diseases1CTD_human
HgeneICAM1C0026640Mouth Neoplasms1CTD_human
HgeneICAM1C0026769Multiple Sclerosis1CTD_human
HgeneICAM1C0027051Myocardial Infarction1CTD_human
HgeneICAM1C0027055Myocardial Reperfusion Injury1CTD_human
HgeneICAM1C0027720Nephrosis1CTD_human
HgeneICAM1C0028754Obesity1CTD_human
HgeneICAM1C0032231Pleurisy1CTD_human
HgeneICAM1C0033578Prostatic Neoplasms1CTD_human
HgeneICAM1C0035235Respiratory Syncytial Virus Infections1CTD_human
HgeneICAM1C0035309Retinal Diseases1CTD_human
HgeneICAM1C0036341Schizophrenia1PSYGENET
HgeneICAM1C0036982Shock, Hemorrhagic1CTD_human
HgeneICAM1C0038454Cerebrovascular accident1CTD_human
HgeneICAM1C0041948Uremia1CTD_human
HgeneICAM1C0042109Urticaria1CTD_human
HgeneICAM1C0085129Bronchial Hyperreactivity1CTD_human
HgeneICAM1C0151744Myocardial Ischemia1CTD_human
HgeneICAM1C0153381Malignant neoplasm of mouth1CTD_human
HgeneICAM1C0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneICAM1C0282548Leukostasis1CTD_human
HgeneICAM1C0376358Malignant neoplasm of prostate1CTD_human
HgeneICAM1C0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneICAM1C0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneICAM1C0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneICAM1C0751324Multiple Sclerosis, Acute Fulminating1CTD_human
HgeneICAM1C0751845Middle Cerebral Artery Embolus1CTD_human
HgeneICAM1C0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneICAM1C0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneICAM1C0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneICAM1C0751849Right Middle Cerebral Artery Infarction1CTD_human
HgeneICAM1C0751956Acute Cerebrovascular Accidents1CTD_human
HgeneICAM1C1563937Atherogenesis1CTD_human
HgeneICAM1C4721453Peripheral Nervous System Diseases1CTD_human