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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGF2R-PPAP2A (FusionGDB2 ID:38384)

Fusion Gene Summary for IGF2R-PPAP2A

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2R-PPAP2A
Fusion gene ID: 38384
HgeneTgene
Gene symbol

IGF2R

PPAP2A

Gene ID

3482

8611

Gene nameinsulin like growth factor 2 receptorphospholipid phosphatase 1
SynonymsCD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRILLP1a|LPP1|PAP-2a|PAP2|PPAP2A
Cytomap

6q25.3

5q11.2

Type of geneprotein-codingprotein-coding
Descriptioncation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptorphospholipid phosphatase 1lipid phosphate phosphohydrolase 1aphosphatidate phosphohydrolase type 2aphosphatidic acid phosphatase 2aphosphatidic acid phosphatase type 2Aphosphatidic acid phosphohydrolase type 2atype-2 phosphatidic acid phosphatase al
Modification date2020031520200313
UniProtAcc

P11717

.
Ensembl transtripts involved in fusion geneENST00000356956, ENST00000475584, 
ENST00000264775, ENST00000307259, 
ENST00000515132, 
Fusion gene scores* DoF score23 X 16 X 11=404810 X 5 X 6=300
# samples 2510
** MAII scorelog2(25/4048*10)=-4.01720929003222
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGF2R [Title/Abstract] AND PPAP2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGF2R(160448346)-PPAP2A(54737736), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPAP2A

GO:0006644

phospholipid metabolic process

9305923|9705349|15461590

TgenePPAP2A

GO:0006670

sphingosine metabolic process

9705349

TgenePPAP2A

GO:0006672

ceramide metabolic process

9305923|9705349

TgenePPAP2A

GO:0046839

phospholipid dephosphorylation

9305923|9705349|15461590|16464866


check buttonFusion gene breakpoints across IGF2R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPAP2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-DQ-7591IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-
ChimerDB4HNSCTCGA-DQ-7591IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-


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Fusion Gene ORF analysis for IGF2R-PPAP2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356956ENST00000264775IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-
In-frameENST00000356956ENST00000307259IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-
5CDS-5UTRENST00000356956ENST00000515132IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-
intron-3CDSENST00000475584ENST00000264775IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-
intron-3CDSENST00000475584ENST00000307259IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-
intron-5UTRENST00000475584ENST00000515132IGF2Rchr6

160448346

+PPAP2Achr5

54737736

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356956IGF2Rchr6160448346+ENST00000264775PPAP2Achr554737736-1640924611287408
ENST00000356956IGF2Rchr6160448346+ENST00000307259PPAP2Achr554737736-1609924611287408

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356956ENST00000264775IGF2Rchr6160448346+PPAP2Achr554737736-0.0047654590.99523455
ENST00000356956ENST00000307259IGF2Rchr6160448346+PPAP2Achr554737736-0.0053580460.9946419

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Fusion Genomic Features for IGF2R-PPAP2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGF2Rchr6160448346+PPAP2Achr554737733-0.999961853.81E-05
IGF2Rchr6160448346+PPAP2Achr554737733-0.999961853.81E-05

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IGF2R-PPAP2A


check button Go to

FGviewer for the breakpoints of chr6:160448346-chr5:54737736

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2R

P11717

.
FUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+64847_163258.66666666666672492.0DomainMRH 1
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526168_171164.66666666666666286.0RegionPhosphatase sequence motif II
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526216_227164.66666666666666286.0RegionPhosphatase sequence motif III
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926168_171163.66666666666666285.0RegionPhosphatase sequence motif II
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926216_227163.66666666666666285.0RegionPhosphatase sequence motif III
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526186_199164.66666666666666286.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526221_229164.66666666666666286.0Topological domainExtracellular
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526251_284164.66666666666666286.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926186_199163.66666666666666285.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926221_229163.66666666666666285.0Topological domainExtracellular
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926251_284163.66666666666666285.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526165_185164.66666666666666286.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526200_220164.66666666666666286.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526230_250164.66666666666666286.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926165_185163.66666666666666285.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926200_220163.66666666666666285.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926230_250163.66666666666666285.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481082_1219258.66666666666672492.0DomainMRH 8
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481225_1363258.66666666666672492.0DomainMRH 9
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481367_1508258.66666666666672492.0DomainMRH 10
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481514_1648258.66666666666672492.0DomainMRH 11
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481650_1797258.66666666666672492.0DomainMRH 12
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+648172_320258.66666666666672492.0DomainMRH 2
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481802_1989258.66666666666672492.0DomainFibronectin type-II
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6481992_2127258.66666666666672492.0DomainMRH 14
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6482135_2280258.66666666666672492.0DomainMRH 15
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+648326_468258.66666666666672492.0DomainMRH 3
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+648473_619258.66666666666672492.0DomainMRH 4
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+648625_762258.66666666666672492.0DomainMRH 5
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+648765_924258.66666666666672492.0DomainMRH 6
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+648932_1079258.66666666666672492.0DomainMRH 7
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6482328_2491258.66666666666672492.0Topological domainCytoplasmic
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+64841_2304258.66666666666672492.0Topological domainLumenal
HgeneIGF2Rchr6:160448346chr5:54737736ENST00000356956+6482305_2327258.66666666666672492.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST00000264775265_7164.66666666666666286.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
TgenePPAP2Achr6:160448346chr5:54737736ENST00000307259265_7163.66666666666666285.0MotifPDZ-binding%3B involved in localization to the apical cell membrane
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526120_128164.66666666666666286.0RegionPhosphatase sequence motif I
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926120_128163.66666666666666285.0RegionPhosphatase sequence motif I
TgenePPAP2Achr6:160448346chr5:54737736ENST0000026477526116_164164.66666666666666286.0Topological domainExtracellular
TgenePPAP2Achr6:160448346chr5:54737736ENST00000264775261_6164.66666666666666286.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST000002647752628_53164.66666666666666286.0Topological domainExtracellular
TgenePPAP2Achr6:160448346chr5:54737736ENST000002647752675_94164.66666666666666286.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST0000030725926116_164163.66666666666666285.0Topological domainExtracellular
TgenePPAP2Achr6:160448346chr5:54737736ENST00000307259261_6163.66666666666666285.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST000003072592628_53163.66666666666666285.0Topological domainExtracellular
TgenePPAP2Achr6:160448346chr5:54737736ENST000003072592675_94163.66666666666666285.0Topological domainCytoplasmic
TgenePPAP2Achr6:160448346chr5:54737736ENST000002647752654_74164.66666666666666286.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST00000264775267_27164.66666666666666286.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST000002647752695_115164.66666666666666286.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST000003072592654_74163.66666666666666285.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST00000307259267_27163.66666666666666285.0TransmembraneHelical
TgenePPAP2Achr6:160448346chr5:54737736ENST000003072592695_115163.66666666666666285.0TransmembraneHelical


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Fusion Gene Sequence for IGF2R-PPAP2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356956_ENST00000264775_TCGA-DQ-7591_IGF2R_chr6_160448346_+_PPAP2A_chr5_54737736_length(transcript)=1640nt_BP=924nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG
TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGGTGACTCTGTTTT
GAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGAGTCCAGAGCAGCATTGC
CTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGGAGGACCACTGCAGCCTG
CAAGAAAGACATATTTAAAGCAAATAAGGAGGTGCCATGCTATGTGTTTGATGAAGAGTTGAGGAAGCATGATCTCAATCCTCTGATCAA
GCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATGTTTGTAGAGACATAGACACACTACGAGACCC
AGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACCAGGCGTTTGATGTTGGCCAGCCCCGGGACGG
ACTGAAGCTGGTGCGCAAGGACAGGTTGTCCTTCTATTCAGGCCACTCTTCGTTTTCCATGTACTGCATGCTGTTTGTGGCACTTTATCT
TCAAGCCAGGATGAAGGGAGACTGGGCAAGACTCTTACGCCCCACACTGCAATTTGGTCTTGTTGCCGTATCCATTTATGTGGGCCTTTC
TCGAGTTTCTGATTATAAACACCACTGGAGCGATGTGTTGACTGGACTCATTCAGGGAGCTCTGGTTGCAATATTAGTTGCTGTATATGT
ATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAAGAGGAGGACTCTCATACAACTCTGCATGAAACACCAACAACTGGGAA
TCACTATCCGAGCAATCACCAGCCTTGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGGCCTGTTTTCTAAAGGAAAATGATTGCCACAAGG
CAAGAGGATGCATCTTTCTTCCTGGTGTACAAGCCTTTAAAGACTTCTGCTGCTGCTATGCCTCTTGGATGCACACTTTGTGTGTACATA
GTTACCTTTAACTCAGTGGTTATCTAATAGCTCTAAACTCATTAAAAAAACTCCAAGCCTTCCACCAAAACAGTGCCCCACCTGTATACA
TTTTTATTAAAAAAATGTAATGCTTATGTATAAACATGTATGTAATATGCTTTCTATGAATGATGTTTGATTTAAATATAATACATATTA

>In-frame_ENST00000356956_ENST00000264775_TCGA-DQ-7591_IGF2R_chr6_160448346_+_PPAP2A_chr5_54737736_length(amino acids)=408AA_start in transcript=61_stop in transcript=1287
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVH
YFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQ
AFDVGQPRDGLKLVRKDRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGA

--------------------------------------------------------------
>In-frame_ENST00000356956_ENST00000307259_TCGA-DQ-7591_IGF2R_chr6_160448346_+_PPAP2A_chr5_54737736_length(transcript)=1609nt_BP=924nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG
TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGGTGACTCTGTTTT
GAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGAGTCCAGAGCAGCATTGC
CTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGGAGGACCACTGCAGCCTG
CAAGAAAGACATATTTAAAGCAAATAAGGAGGTGCCATGCTATGTGTTTGATGAAGAGTTGAGGAAGCATGATCTCAATCCTCTGATCAA
GCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATGTTTGTAGAGACATAGACACACTACGAGACCC
AGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACCAGGCGTTTGATGTTGGCCAGCCCCGGGACGG
ACTGAAGCTGGTGCGCAAGGACAGGTTGTCCTTCTATTCAGGCCACTCTTCGTTTTCCATGTACTGCATGCTGTTTGTGGCACTTTATCT
TCAAGCCAGGATGAAGGGAGACTGGGCAAGACTCTTACGCCCCACACTGCAATTTGGTCTTGTTGCCGTATCCATTTATGTGGGCCTTTC
TCGAGTTTCTGATTATAAACACCACTGGAGCGATGTGTTGACTGGACTCATTCAGGGAGCTCTGGTTGCAATATTAGTTGCTGTATATGT
ATCGGATTTCTTCAAAGAAAGAACTTCTTTTAAAGAAAGAAAAGAGGAGGACTCTCATACAACTCTGCATGAAACACCAACAACTGGGAA
TCACTATCCGAGCAATCACCAGCCTTGAAAGGCAGCAGGGTGCCCAGGTGAAGCTGGCCTGTTTTCTAAAGGAAAATGATTGCCACAAGG
CAAGAGGATGCATCTTTCTTCCTGGTGTACAAGCCTTTAAAGACTTCTGCTGCTGCTATGCCTCTTGGATGCACACTTTGTGTGTACATA
GTTACCTTTAACTCAGTGGTTATCTAATAGCTCTAAACTCATTAAAAAAACTCCAAGCCTTCCACCAAAACAGTGCCCCACCTGTATACA

>In-frame_ENST00000356956_ENST00000307259_TCGA-DQ-7591_IGF2R_chr6_160448346_+_PPAP2A_chr5_54737736_length(amino acids)=408AA_start in transcript=61_stop in transcript=1287
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVH
YFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQ
AFDVGQPRDGLKLVRKDRLSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGA

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Fusion Gene PPI Analysis for IGF2R-PPAP2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGF2R-PPAP2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIGF2RP11717DB14751Mecasermin rinfabateBiotechApproved
HgeneIGF2RP11717DB14751Mecasermin rinfabateBiotechApproved
HgeneIGF2RP11717DB01277MecaserminBiotechApproved|Investigational
HgeneIGF2RP11717DB01277MecaserminBiotechApproved|Investigational
HgeneIGF2RP11717DB13173Cerliponase alfaLigandBiotechApproved|Investigational
HgeneIGF2RP11717DB13173Cerliponase alfaLigandBiotechApproved|Investigational

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Related Diseases for IGF2R-PPAP2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGF2RC0024115Lung diseases2CTD_human
HgeneIGF2RC0235833Congenital diaphragmatic hernia2CTD_human
HgeneIGF2RC0265699Congenital hernia of foramen of Morgagni2CTD_human
HgeneIGF2RC0265700Congenital hernia of foramen of Bochdalek2CTD_human
HgeneIGF2RC0002395Alzheimer's Disease1CTD_human
HgeneIGF2RC0011265Presenile dementia1CTD_human
HgeneIGF2RC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIGF2RC0030567Parkinson Disease1CTD_human
HgeneIGF2RC0033578Prostatic Neoplasms1CTD_human
HgeneIGF2RC0242973Ventricular Dysfunction1CTD_human
HgeneIGF2RC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneIGF2RC0376358Malignant neoplasm of prostate1CTD_human
HgeneIGF2RC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneIGF2RC0546126Acute Confusional Senile Dementia1CTD_human
HgeneIGF2RC0553980Endomyocardial Fibrosis1CTD_human
HgeneIGF2RC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneIGF2RC0750901Alzheimer Disease, Early Onset1CTD_human
HgeneIGF2RC0752347Lewy Body Disease1CTD_human
HgeneIGF2RC2239176Liver carcinoma1CGI;CTD_human