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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGF2R-SLC22A1 (FusionGDB2 ID:38389)

Fusion Gene Summary for IGF2R-SLC22A1

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2R-SLC22A1
Fusion gene ID: 38389
HgeneTgene
Gene symbol

IGF2R

SLC22A1

Gene ID

3482

6580

Gene nameinsulin like growth factor 2 receptorsolute carrier family 22 member 1
SynonymsCD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRIHOCT1|OCT1|oct1_cds
Cytomap

6q25.3

6q25.3

Type of geneprotein-codingprotein-coding
Descriptioncation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptorsolute carrier family 22 member 1organic cation transporter 1solute carrier family 22 (organic cation transporter), member 1
Modification date2020031520200329
UniProtAcc

P11717

.
Ensembl transtripts involved in fusion geneENST00000356956, ENST00000475584, 
ENST00000366963, ENST00000324965, 
ENST00000457470, 
Fusion gene scores* DoF score23 X 16 X 11=40483 X 6 X 3=54
# samples 253
** MAII scorelog2(25/4048*10)=-4.01720929003222
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/54*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGF2R [Title/Abstract] AND SLC22A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGF2R(160412355)-SLC22A1(160564573), # samples:1
IGF2R(160412355)-SLC22A1(160551136), # samples:1
Anticipated loss of major functional domain due to fusion event.IGF2R-SLC22A1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
IGF2R-SLC22A1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
IGF2R-SLC22A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IGF2R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC22A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A6VV-01AIGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
ChimerDB4BRCATCGA-A7-A6VV-01AIGF2Rchr6

160412355

+SLC22A1chr6

160551136

+


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Fusion Gene ORF analysis for IGF2R-SLC22A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356956ENST00000366963IGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
In-frameENST00000356956ENST00000324965IGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
In-frameENST00000356956ENST00000457470IGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
intron-3CDSENST00000475584ENST00000366963IGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
intron-3CDSENST00000475584ENST00000324965IGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
intron-3CDSENST00000475584ENST00000457470IGF2Rchr6

160412355

+SLC22A1chr6

160564573

+
Frame-shiftENST00000356956ENST00000366963IGF2Rchr6

160412355

+SLC22A1chr6

160551136

+
Frame-shiftENST00000356956ENST00000324965IGF2Rchr6

160412355

+SLC22A1chr6

160551136

+
Frame-shiftENST00000356956ENST00000457470IGF2Rchr6

160412355

+SLC22A1chr6

160551136

+
intron-3CDSENST00000475584ENST00000366963IGF2Rchr6

160412355

+SLC22A1chr6

160551136

+
intron-3CDSENST00000475584ENST00000324965IGF2Rchr6

160412355

+SLC22A1chr6

160551136

+
intron-3CDSENST00000475584ENST00000457470IGF2Rchr6

160412355

+SLC22A1chr6

160551136

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356956IGF2Rchr6160412355+ENST00000366963SLC22A1chr6160564573+96243761825254
ENST00000356956IGF2Rchr6160412355+ENST00000324965SLC22A1chr6160564573+68243761681207
ENST00000356956IGF2Rchr6160412355+ENST00000457470SLC22A1chr6160564573+61343761612184

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356956ENST00000366963IGF2Rchr6160412355+SLC22A1chr6160564573+0.01115780.9888421
ENST00000356956ENST00000324965IGF2Rchr6160412355+SLC22A1chr6160564573+0.148297060.8517029
ENST00000356956ENST00000457470IGF2Rchr6160412355+SLC22A1chr6160564573+0.0287061350.9712939

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Fusion Genomic Features for IGF2R-SLC22A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGF2Rchr6160412355+SLC22A1chr6160564572+0.0001056370.9998944
IGF2Rchr6160412355+SLC22A1chr6160551135+3.19E-070.99999964
IGF2Rchr6160412355+SLC22A1chr6160564572+0.0001056370.9998944
IGF2Rchr6160412355+SLC22A1chr6160551135+3.19E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IGF2R-SLC22A1


check button Go to

FGviewer for the breakpoints of chr6:160412355-chr6:160564573

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2R

P11717

.
FUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610424_431425.3333333333333507.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610453_464425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610486_492425.3333333333333507.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610514_554425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611424_431425.3333333333333555.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611453_464425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611486_492425.3333333333333555.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611514_554425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069424_431425.3333333333333484.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069453_464425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069486_492425.3333333333333484.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069514_554425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610432_452425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610465_485425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610493_513425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611432_452425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611465_485425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611493_513425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069432_452425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069465_485425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069493_513425.3333333333333484.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481082_121996.333333333333332492.0DomainMRH 8
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481225_136396.333333333333332492.0DomainMRH 9
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481367_150896.333333333333332492.0DomainMRH 10
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481514_164896.333333333333332492.0DomainMRH 11
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481650_179796.333333333333332492.0DomainMRH 12
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+248172_32096.333333333333332492.0DomainMRH 2
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481802_198996.333333333333332492.0DomainFibronectin type-II
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2481992_212796.333333333333332492.0DomainMRH 14
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2482135_228096.333333333333332492.0DomainMRH 15
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+248326_46896.333333333333332492.0DomainMRH 3
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+248473_61996.333333333333332492.0DomainMRH 4
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+24847_16396.333333333333332492.0DomainMRH 1
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+248625_76296.333333333333332492.0DomainMRH 5
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+248765_92496.333333333333332492.0DomainMRH 6
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+248932_107996.333333333333332492.0DomainMRH 7
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2482328_249196.333333333333332492.0Topological domainCytoplasmic
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+24841_230496.333333333333332492.0Topological domainLumenal
HgeneIGF2Rchr6:160412355chr6:160564573ENST00000356956+2482305_232796.333333333333332492.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610171_176425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610198_206425.3333333333333507.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST000003249656101_21425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610230_235425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610257_262425.3333333333333507.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610284_347425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610369_376425.3333333333333507.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610398_402425.3333333333333507.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000032496561043_149425.3333333333333507.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611171_176425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611198_206425.3333333333333555.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST000003669636111_21425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611230_235425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611257_262425.3333333333333555.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611284_347425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611369_376425.3333333333333555.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611398_402425.3333333333333555.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000036696361143_149425.3333333333333555.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069171_176425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069198_206425.3333333333333484.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000457470691_21425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069230_235425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069257_262425.3333333333333484.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069284_347425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069369_376425.3333333333333484.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069398_402425.3333333333333484.0Topological domainCytoplasmic
TgeneSLC22A1chr6:160412355chr6:160564573ENST000004574706943_149425.3333333333333484.0Topological domainExtracellular
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610150_170425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610177_197425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610207_229425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000032496561022_42425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610236_256425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610263_283425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610348_368425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610377_397425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000324965610403_423425.3333333333333507.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611150_170425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611177_197425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611207_229425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000036696361122_42425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611236_256425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611263_283425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611348_368425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611377_397425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST00000366963611403_423425.3333333333333555.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069150_170425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069177_197425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069207_229425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST000004574706922_42425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069236_256425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069263_283425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069348_368425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069377_397425.3333333333333484.0TransmembraneHelical
TgeneSLC22A1chr6:160412355chr6:160564573ENST0000045747069403_423425.3333333333333484.0TransmembraneHelical


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Fusion Gene Sequence for IGF2R-SLC22A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356956_ENST00000366963_TCGA-A7-A6VV-01A_IGF2R_chr6_160412355_+_SLC22A1_chr6_160564573_length(transcript)=962nt_BP=437nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG
TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGACCTGCACTGGTT
AAACATCATAATCATGTGTGTTGGCCGAATGGGAATCACCATTGCAATACAAATGATCTGCCTGGTGAATGCTGAGCTGTACCCCACATT
CGTCAGGAACCTCGGAGTGATGGTGTGTTCCTCCCTGTGTGACATAGGTGGGATAATCACCCCCTTCATAGTCTTCAGGCTGAGGGAGGT
CTGGCAAGCCTTGCCCCTCATTTTGTTTGCGGTGTTGGGCCTGCTTGCCGCGGGAGTGACGCTACTTCTTCCAGAGACCAAGGGGGTCGC
TTTGCCAGAGACCATGAAGGACGCCGAGAACCTTGGGAGAAAAGCAAAGCCCAAAGAAAACACGATTTACCTTAAGGTCCAAACCTCAGA
ACCCTCGGGCACCTGAGAGAGATGTTTTGCGGCGATGTCGTGTTGGAGGGATGAAGATGGAGTTATCCTCTGCAGAAATTCCTAGACGCC

>In-frame_ENST00000356956_ENST00000366963_TCGA-A7-A6VV-01A_IGF2R_chr6_160412355_+_SLC22A1_chr6_160564573_length(amino acids)=254AA_start in transcript=61_stop in transcript=825
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT

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>In-frame_ENST00000356956_ENST00000324965_TCGA-A7-A6VV-01A_IGF2R_chr6_160412355_+_SLC22A1_chr6_160564573_length(transcript)=682nt_BP=437nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG
TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGACCTGCACTGGTT
AAACATCATAATCATGTGTGTTGGCCGAATGGGAATCACCATTGCAATACAAATGATCTGCCTGGTGAATGCTGAGCTGTACCCCACATT
CGTCAGCGGTGTTGGGCCTGCTTGCCGCGGGAGTGACGCTACTTCTTCCAGAGACCAAGGGGGTCGCTTTGCCAGAGACCATGAAGGACG

>In-frame_ENST00000356956_ENST00000324965_TCGA-A7-A6VV-01A_IGF2R_chr6_160412355_+_SLC22A1_chr6_160564573_length(amino acids)=207AA_start in transcript=61_stop in transcript=681
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVGPACRGSDATSSRDQG

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>In-frame_ENST00000356956_ENST00000457470_TCGA-A7-A6VV-01A_IGF2R_chr6_160412355_+_SLC22A1_chr6_160564573_length(transcript)=613nt_BP=437nt
CGAGCCCAGTCGAGCCGCGCTCACCTCGGGCTCCCGCTCCGTCTCCACCTCCGCCTTTGCCCTGGCGGCGCGACCCCGTCCCGGGCGCGG
CCCCCAGCAGTCGCGCGCCGTTAGCCTCGCGCCCGCCGCGCAGTCCGGGCCCGGCGCGATGGGGGCCGCCGCCGGCCGGAGCCCCCACCT
GGGGCCCGCGCCCGCCCGCCGCCCGCAGCGCTCTCTGCTCCTGCTGCAGCTGCTGCTGCTCGTCGCTGCCCCGGGGTCCACGCAGGCCCA
GGCCGCCCCGTTCCCCGAGCTGTGCAGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAAG
TGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGACCTGCACTGGTT
AAACATCATAATCATGTGTGTTGGCCGAATGGGAATCACCATTGCAATACAAATGATCTGCCTGGTGAATGCTGAGCTGTACCCCACATT

>In-frame_ENST00000356956_ENST00000457470_TCGA-A7-A6VV-01A_IGF2R_chr6_160412355_+_SLC22A1_chr6_160564573_length(amino acids)=184AA_start in transcript=61_stop in transcript=612
MAARPRPGRGPQQSRAVSLAPAAQSGPGAMGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNN
VLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRKAKPKENTIYLKVQTSEP

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Fusion Gene PPI Analysis for IGF2R-SLC22A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGF2R-SLC22A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneIGF2RP11717DB14751Mecasermin rinfabateBiotechApproved
HgeneIGF2RP11717DB14751Mecasermin rinfabateBiotechApproved
HgeneIGF2RP11717DB01277MecaserminBiotechApproved|Investigational
HgeneIGF2RP11717DB01277MecaserminBiotechApproved|Investigational
HgeneIGF2RP11717DB13173Cerliponase alfaLigandBiotechApproved|Investigational
HgeneIGF2RP11717DB13173Cerliponase alfaLigandBiotechApproved|Investigational

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Related Diseases for IGF2R-SLC22A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIGF2RC0024115Lung diseases2CTD_human
HgeneIGF2RC0235833Congenital diaphragmatic hernia2CTD_human
HgeneIGF2RC0265699Congenital hernia of foramen of Morgagni2CTD_human
HgeneIGF2RC0265700Congenital hernia of foramen of Bochdalek2CTD_human
HgeneIGF2RC0002395Alzheimer's Disease1CTD_human
HgeneIGF2RC0011265Presenile dementia1CTD_human
HgeneIGF2RC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIGF2RC0030567Parkinson Disease1CTD_human
HgeneIGF2RC0033578Prostatic Neoplasms1CTD_human
HgeneIGF2RC0242973Ventricular Dysfunction1CTD_human
HgeneIGF2RC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneIGF2RC0376358Malignant neoplasm of prostate1CTD_human
HgeneIGF2RC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneIGF2RC0546126Acute Confusional Senile Dementia1CTD_human
HgeneIGF2RC0553980Endomyocardial Fibrosis1CTD_human
HgeneIGF2RC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneIGF2RC0750901Alzheimer Disease, Early Onset1CTD_human
HgeneIGF2RC0752347Lewy Body Disease1CTD_human
HgeneIGF2RC2239176Liver carcinoma1CGI;CTD_human
TgeneSLC22A1C0007102Malignant tumor of colon1CTD_human
TgeneSLC22A1C0009375Colonic Neoplasms1CTD_human
TgeneSLC22A1C0028754Obesity1CTD_human
TgeneSLC22A1C2239176Liver carcinoma1CTD_human