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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC3-LRRC59 (FusionGDB2 ID:388)

Fusion Gene Summary for ABCC3-LRRC59

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC3-LRRC59
Fusion gene ID: 388
HgeneTgene
Gene symbol

ABCC3

LRRC59

Gene ID

8714

55379

Gene nameATP binding cassette subfamily C member 3leucine rich repeat containing 59
SynonymsABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2PRO1855|p34
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrugleucine-rich repeat-containing protein 59ribosome-binding protein p34
Modification date2020031320200313
UniProtAcc

O15438

Q96AG4

Ensembl transtripts involved in fusion geneENST00000285238, ENST00000515707, 
ENST00000427699, ENST00000510891, 
ENST00000225972, ENST00000576448, 
Fusion gene scores* DoF score16 X 12 X 7=13447 X 4 X 6=168
# samples 187
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC3 [Title/Abstract] AND LRRC59 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC3(48712342)-LRRC59(48465493), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC3

GO:0042908

xenobiotic transport

18698235|19334674


check buttonFusion gene breakpoints across ABCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LRRC59 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5263NABCC3chr17

48712342

+LRRC59chr17

48465493

-


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Fusion Gene ORF analysis for ABCC3-LRRC59

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000285238ENST00000225972ABCC3chr17

48712342

+LRRC59chr17

48465493

-
5CDS-intronENST00000285238ENST00000576448ABCC3chr17

48712342

+LRRC59chr17

48465493

-
In-frameENST00000515707ENST00000225972ABCC3chr17

48712342

+LRRC59chr17

48465493

-
5CDS-intronENST00000515707ENST00000576448ABCC3chr17

48712342

+LRRC59chr17

48465493

-
In-frameENST00000427699ENST00000225972ABCC3chr17

48712342

+LRRC59chr17

48465493

-
5CDS-intronENST00000427699ENST00000576448ABCC3chr17

48712342

+LRRC59chr17

48465493

-
intron-3CDSENST00000510891ENST00000225972ABCC3chr17

48712342

+LRRC59chr17

48465493

-
intron-intronENST00000510891ENST00000576448ABCC3chr17

48712342

+LRRC59chr17

48465493

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285238ABCC3chr1748712342+ENST00000225972LRRC59chr1748465493-237012559619186
ENST00000515707ABCC3chr1748712342+ENST00000225972LRRC59chr1748465493-23399449588179
ENST00000427699ABCC3chr1748712342+ENST00000225972LRRC59chr1748465493-237012559619186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285238ENST00000225972ABCC3chr1748712342+LRRC59chr1748465493-0.0065037920.9934962
ENST00000515707ENST00000225972ABCC3chr1748712342+LRRC59chr1748465493-0.0052770370.99472296
ENST00000427699ENST00000225972ABCC3chr1748712342+LRRC59chr1748465493-0.0065037920.9934962

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Fusion Genomic Features for ABCC3-LRRC59


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABCC3-LRRC59


check button Go to

FGviewer for the breakpoints of chr17:48712342-chr17:48465493

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC3

O15438

LRRC59

Q96AG4

FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}.FUNCTION: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC59chr17:48712342chr17:48465493ENST0000022597237148_216143.0308.0Coiled coilOntology_term=ECO:0000255
TgeneLRRC59chr17:48712342chr17:48465493ENST0000022597237248_256143.0308.0Compositional biasNote=Poly-Leu
TgeneLRRC59chr17:48712342chr17:48465493ENST0000022597237266_307143.0308.0Topological domainLumenal
TgeneLRRC59chr17:48712342chr17:48465493ENST0000022597237245_265143.0308.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311291_152315.01528.0DomainABC transporter 2
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131311_59415.01528.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131629_85115.01528.0DomainABC transporter 1
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131971_125215.01528.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121291_152315.0573.0DomainABC transporter 2
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112311_59415.0573.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112629_85115.0573.0DomainABC transporter 1
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112971_125215.0573.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311323_133015.01528.0Nucleotide bindingATP 2
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131661_66815.01528.0Nucleotide bindingATP 1
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121323_133015.0573.0Nucleotide bindingATP 2
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112661_66815.0573.0Nucleotide bindingATP 1
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311043_108515.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311107_110715.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311129_119915.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131121_13215.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311221_122215.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311244_152715.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131154_17115.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131193_30215.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311_3215.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131324_34915.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131371_42615.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131448_45015.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131472_53315.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+13154_7315.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131555_57615.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131598_96315.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+13195_9915.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131985_102115.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121043_108515.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121107_110715.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121129_119915.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112121_13215.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121221_122215.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121244_152715.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112154_17115.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112193_30215.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121_3215.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112324_34915.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112371_42615.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112448_45015.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112472_53315.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+11254_7315.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112555_57615.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112598_96315.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+11295_9915.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112985_102115.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131100_12015.01528.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311022_104215.01528.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311086_110615.01528.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311108_112815.01528.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311200_122015.01528.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+1311223_124315.01528.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131133_15315.01528.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131172_19215.01528.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131303_32315.01528.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+13133_5315.01528.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131350_37015.01528.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131427_44715.01528.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131451_47115.01528.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131534_55415.01528.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131577_59715.01528.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+13174_9415.01528.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48712342chr17:48465493ENST00000285238+131964_98415.01528.0TransmembraneHelical%3B Name%3D12
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112100_12015.0573.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121022_104215.0573.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121086_110615.0573.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121108_112815.0573.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121200_122015.0573.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+1121223_124315.0573.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112133_15315.0573.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112172_19215.0573.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112303_32315.0573.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+11233_5315.0573.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112350_37015.0573.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112427_44715.0573.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112451_47115.0573.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112534_55415.0573.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112577_59715.0573.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+11274_9415.0573.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48712342chr17:48465493ENST00000427699+112964_98415.0573.0TransmembraneHelical%3B Name%3D12
TgeneLRRC59chr17:48712342chr17:48465493ENST0000022597237109_128143.0308.0RepeatNote=LRR 5
TgeneLRRC59chr17:48712342chr17:48465493ENST000002259723710_31143.0308.0RepeatNote=LRR 1
TgeneLRRC59chr17:48712342chr17:48465493ENST000002259723740_62143.0308.0RepeatNote=LRR 2
TgeneLRRC59chr17:48712342chr17:48465493ENST000002259723763_84143.0308.0RepeatNote=LRR 3
TgeneLRRC59chr17:48712342chr17:48465493ENST000002259723786_107143.0308.0RepeatNote=LRR 4
TgeneLRRC59chr17:48712342chr17:48465493ENST00000225972371_244143.0308.0Topological domainCytoplasmic


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Fusion Gene Sequence for ABCC3-LRRC59


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000285238_ENST00000225972_5263N_ABCC3_chr17_48712342_+_LRRC59_chr17_48465493_length(transcript)=2370nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGTGTTACAGCACATGAAGGCCGTGCAGGCAGATCAGGAGCGGGAGAGGCAGCGGC
GGCTGGAAGTAGAACGTGAGGCAGAGAAGAAGCGTGAGGCTAAGCAGCGAGCTAAGGAAGCTCAGGAGCGGGAACTGCGGAAGCGGGAGA
AGGCGGAAGAGAAGGAGCGCCGGAGAAAGGAGTATGATGCCCTCAAAGCAGCCAAGCGGGAGCAGGAGAAGAAACCTAAGAAGGAAGCAA
ATCAGGCCCCGAAATCTAAGTCTGGCTCCCGTCCCCGCAAGCCACCACCCCGGAAGCACACTCGTTCCTGGGCTGTGCTGAAGCTGCTGC
TGCTGCTGCTGCTATTTGGTGTGGCGGGAGGGCTGGTTGCTTGTCGGGTGACAGAGCTGCAGCAGCAGCCCCTCTGCACCAGCGTGAACA
CCATCTATGACAATGCGGTCCAGGGTCTACGCCGCCATGAGATCCTCCAGTGGGTCCTCCAGACCGACTCTCAGCAGTGAGCTTGTCCCC
AGCACCTGCTGCCTCCCAGCCTTGGAGTTTGGATTCCTATGGAATTGGGTTCTGCTGGACACAACCTCTTTTTAGCATCAGACCTACCTG
CCATCATCAAATGGCTGCAGATTGGTACATGAGACCTCCTCTTTGTAGGACTTCTTCATTCCTTAGTCAGGGTTCCCTGAAGGAATGAGG
AGAAATGGGAGGTGGCGGGGGGGCGTGGGGGGCAGTTACCTGCATGCCTAAAGGAGTAGGCTTGGGGGTGGGGAGAGAGAAAACATAGCC
TTTTCTAGTTGTTATATAAAGCTGTGTAAAGGCAAGGCTCGTTTCTACTAAATGGTCAGCTGTCACTACATTTATACTTTTGTATGCCAC
AAACCCTTTCATTCCTCCCTGGGAATCAGGGTAGATCAGGAGGAACTGGGGGGGACTAGAACACCACGCTCAGTAAATCCAGTCTAAACT
GGGAGGTAGGGGTATTCCTGTTTTCTTTAGGACCTCAGAGATGTAAGCATTTTAGCAGCCACACAAAATCTCTGGCTATGAAAGGGACTT
CATGACCATCCAGTCCAATATAACACTTGCAGACAGAGAAACTGAGGTCTTCCATGACTTGCCTAGTCTCCCAGCTAGTTTGAGGCAAAA
CTGGATTCCCACTCTGGTATTCTTTCTTCCCTTTACATCATTTTCCCTCCTTTATAATGTCCTGAGAGACCAGAACTCACACCAGAATCG
ATTATTCCTCAGGTGAAGCATAGACTCTTTCATGGTAGACAGATTTCACGACTCAGAGATAGAAATCTCTTGCTATCATCAGGTCACGGG
CAGCTCCTGTGGAGTCCTGCCCAACTTATGTGGCTTCCATAAAATGGCAACAGTCCAGGCTCCTTGCCTAATTTTAGAGCATTAACTCCC
TAATTGCCAGTAAGCAAGGAGGTGGATCTCTGCAAACCTACACTGTCTATGACAGCTCTAGTTGTACTTGGTGTGACTAAATACCTCAAA
GGCAACCTGCTTCTGCAGGTTTTGAAGTGTCAGCTTCATAAGACACTGAGGTTTAGAATTGTTTGATTCTAGACCATAACTGAAGGGCAT
AAATGGAAACAGGATATGAAGGGAAACAAGTAGCATCATGGAGCTGAAAAGTGGTGCATCACCCAATGGCTAGCACAAACAAGGATCACA
CTGTCCATTCTCTTGTCTGCTAAATTAAGCATTTTCTTGCCTCCTTTGCTTCATCTTTTCACAACAGCTGGATAGAGGGATCAGAAATGA
CTGTGTCATGGTGCTCATTCACTGCAAACTCCCAGTTGCAAGCTCCTTGGCTCCCCCGGAGGGAGCAAGAATCTCATAGTTCAGAGACAC
AGAGGGCCTTTTAGCCCTAATGACCTTTTGGATGGGACTGCAACTCATGACTATCCTGATATTGGAAGAAAGGACTTTGTTAATCTTCTC
CCCCATAGCTCTGCTGCGTAGGTCTACATCTTACTCAGAATCACTACACATTCCTTTAGTCTTCCTCCAAGCTCCAGAGCCATTGGTACA
AATGCTTTATTGAAACTAAATACATAATACACACAATGAGATGAAGACAATATAGAAGTCCGCATAGTCATCATAATCCCGTTCCTTGGC
CGGTTGAGGCAGCTCAGTGGCTGAGCCCAGTCAAGCCAACCCGCAGCTTCACTCACGACTTCAAGATTTGATGCTAATTCTTTTGGATTT

>In-frame_ENST00000285238_ENST00000225972_5263N_ABCC3_chr17_48712342_+_LRRC59_chr17_48465493_length(amino acids)=186AA_start in transcript=59_stop in transcript=619
MQPRLGPMDALCGSGELGSKFWVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKR
EQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVL

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>In-frame_ENST00000515707_ENST00000225972_5263N_ABCC3_chr17_48712342_+_LRRC59_chr17_48465493_length(transcript)=2339nt_BP=94nt
CGGGGGCAGGGAGACCGGACCCAGAGGCACTGGGCCGCGCCTCGGCCCCATGGACGCCCTGTGCGGTTCCGGGGAGCTCGGCTCCAAGTT
CTGGGTGTTACAGCACATGAAGGCCGTGCAGGCAGATCAGGAGCGGGAGAGGCAGCGGCGGCTGGAAGTAGAACGTGAGGCAGAGAAGAA
GCGTGAGGCTAAGCAGCGAGCTAAGGAAGCTCAGGAGCGGGAACTGCGGAAGCGGGAGAAGGCGGAAGAGAAGGAGCGCCGGAGAAAGGA
GTATGATGCCCTCAAAGCAGCCAAGCGGGAGCAGGAGAAGAAACCTAAGAAGGAAGCAAATCAGGCCCCGAAATCTAAGTCTGGCTCCCG
TCCCCGCAAGCCACCACCCCGGAAGCACACTCGTTCCTGGGCTGTGCTGAAGCTGCTGCTGCTGCTGCTGCTATTTGGTGTGGCGGGAGG
GCTGGTTGCTTGTCGGGTGACAGAGCTGCAGCAGCAGCCCCTCTGCACCAGCGTGAACACCATCTATGACAATGCGGTCCAGGGTCTACG
CCGCCATGAGATCCTCCAGTGGGTCCTCCAGACCGACTCTCAGCAGTGAGCTTGTCCCCAGCACCTGCTGCCTCCCAGCCTTGGAGTTTG
GATTCCTATGGAATTGGGTTCTGCTGGACACAACCTCTTTTTAGCATCAGACCTACCTGCCATCATCAAATGGCTGCAGATTGGTACATG
AGACCTCCTCTTTGTAGGACTTCTTCATTCCTTAGTCAGGGTTCCCTGAAGGAATGAGGAGAAATGGGAGGTGGCGGGGGGGCGTGGGGG
GCAGTTACCTGCATGCCTAAAGGAGTAGGCTTGGGGGTGGGGAGAGAGAAAACATAGCCTTTTCTAGTTGTTATATAAAGCTGTGTAAAG
GCAAGGCTCGTTTCTACTAAATGGTCAGCTGTCACTACATTTATACTTTTGTATGCCACAAACCCTTTCATTCCTCCCTGGGAATCAGGG
TAGATCAGGAGGAACTGGGGGGGACTAGAACACCACGCTCAGTAAATCCAGTCTAAACTGGGAGGTAGGGGTATTCCTGTTTTCTTTAGG
ACCTCAGAGATGTAAGCATTTTAGCAGCCACACAAAATCTCTGGCTATGAAAGGGACTTCATGACCATCCAGTCCAATATAACACTTGCA
GACAGAGAAACTGAGGTCTTCCATGACTTGCCTAGTCTCCCAGCTAGTTTGAGGCAAAACTGGATTCCCACTCTGGTATTCTTTCTTCCC
TTTACATCATTTTCCCTCCTTTATAATGTCCTGAGAGACCAGAACTCACACCAGAATCGATTATTCCTCAGGTGAAGCATAGACTCTTTC
ATGGTAGACAGATTTCACGACTCAGAGATAGAAATCTCTTGCTATCATCAGGTCACGGGCAGCTCCTGTGGAGTCCTGCCCAACTTATGT
GGCTTCCATAAAATGGCAACAGTCCAGGCTCCTTGCCTAATTTTAGAGCATTAACTCCCTAATTGCCAGTAAGCAAGGAGGTGGATCTCT
GCAAACCTACACTGTCTATGACAGCTCTAGTTGTACTTGGTGTGACTAAATACCTCAAAGGCAACCTGCTTCTGCAGGTTTTGAAGTGTC
AGCTTCATAAGACACTGAGGTTTAGAATTGTTTGATTCTAGACCATAACTGAAGGGCATAAATGGAAACAGGATATGAAGGGAAACAAGT
AGCATCATGGAGCTGAAAAGTGGTGCATCACCCAATGGCTAGCACAAACAAGGATCACACTGTCCATTCTCTTGTCTGCTAAATTAAGCA
TTTTCTTGCCTCCTTTGCTTCATCTTTTCACAACAGCTGGATAGAGGGATCAGAAATGACTGTGTCATGGTGCTCATTCACTGCAAACTC
CCAGTTGCAAGCTCCTTGGCTCCCCCGGAGGGAGCAAGAATCTCATAGTTCAGAGACACAGAGGGCCTTTTAGCCCTAATGACCTTTTGG
ATGGGACTGCAACTCATGACTATCCTGATATTGGAAGAAAGGACTTTGTTAATCTTCTCCCCCATAGCTCTGCTGCGTAGGTCTACATCT
TACTCAGAATCACTACACATTCCTTTAGTCTTCCTCCAAGCTCCAGAGCCATTGGTACAAATGCTTTATTGAAACTAAATACATAATACA
CACAATGAGATGAAGACAATATAGAAGTCCGCATAGTCATCATAATCCCGTTCCTTGGCCGGTTGAGGCAGCTCAGTGGCTGAGCCCAGT

>In-frame_ENST00000515707_ENST00000225972_5263N_ABCC3_chr17_48712342_+_LRRC59_chr17_48465493_length(amino acids)=179AA_start in transcript=49_stop in transcript=588
MDALCGSGELGSKFWVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPK

--------------------------------------------------------------
>In-frame_ENST00000427699_ENST00000225972_5263N_ABCC3_chr17_48712342_+_LRRC59_chr17_48465493_length(transcript)=2370nt_BP=125nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGTGTTACAGCACATGAAGGCCGTGCAGGCAGATCAGGAGCGGGAGAGGCAGCGGC
GGCTGGAAGTAGAACGTGAGGCAGAGAAGAAGCGTGAGGCTAAGCAGCGAGCTAAGGAAGCTCAGGAGCGGGAACTGCGGAAGCGGGAGA
AGGCGGAAGAGAAGGAGCGCCGGAGAAAGGAGTATGATGCCCTCAAAGCAGCCAAGCGGGAGCAGGAGAAGAAACCTAAGAAGGAAGCAA
ATCAGGCCCCGAAATCTAAGTCTGGCTCCCGTCCCCGCAAGCCACCACCCCGGAAGCACACTCGTTCCTGGGCTGTGCTGAAGCTGCTGC
TGCTGCTGCTGCTATTTGGTGTGGCGGGAGGGCTGGTTGCTTGTCGGGTGACAGAGCTGCAGCAGCAGCCCCTCTGCACCAGCGTGAACA
CCATCTATGACAATGCGGTCCAGGGTCTACGCCGCCATGAGATCCTCCAGTGGGTCCTCCAGACCGACTCTCAGCAGTGAGCTTGTCCCC
AGCACCTGCTGCCTCCCAGCCTTGGAGTTTGGATTCCTATGGAATTGGGTTCTGCTGGACACAACCTCTTTTTAGCATCAGACCTACCTG
CCATCATCAAATGGCTGCAGATTGGTACATGAGACCTCCTCTTTGTAGGACTTCTTCATTCCTTAGTCAGGGTTCCCTGAAGGAATGAGG
AGAAATGGGAGGTGGCGGGGGGGCGTGGGGGGCAGTTACCTGCATGCCTAAAGGAGTAGGCTTGGGGGTGGGGAGAGAGAAAACATAGCC
TTTTCTAGTTGTTATATAAAGCTGTGTAAAGGCAAGGCTCGTTTCTACTAAATGGTCAGCTGTCACTACATTTATACTTTTGTATGCCAC
AAACCCTTTCATTCCTCCCTGGGAATCAGGGTAGATCAGGAGGAACTGGGGGGGACTAGAACACCACGCTCAGTAAATCCAGTCTAAACT
GGGAGGTAGGGGTATTCCTGTTTTCTTTAGGACCTCAGAGATGTAAGCATTTTAGCAGCCACACAAAATCTCTGGCTATGAAAGGGACTT
CATGACCATCCAGTCCAATATAACACTTGCAGACAGAGAAACTGAGGTCTTCCATGACTTGCCTAGTCTCCCAGCTAGTTTGAGGCAAAA
CTGGATTCCCACTCTGGTATTCTTTCTTCCCTTTACATCATTTTCCCTCCTTTATAATGTCCTGAGAGACCAGAACTCACACCAGAATCG
ATTATTCCTCAGGTGAAGCATAGACTCTTTCATGGTAGACAGATTTCACGACTCAGAGATAGAAATCTCTTGCTATCATCAGGTCACGGG
CAGCTCCTGTGGAGTCCTGCCCAACTTATGTGGCTTCCATAAAATGGCAACAGTCCAGGCTCCTTGCCTAATTTTAGAGCATTAACTCCC
TAATTGCCAGTAAGCAAGGAGGTGGATCTCTGCAAACCTACACTGTCTATGACAGCTCTAGTTGTACTTGGTGTGACTAAATACCTCAAA
GGCAACCTGCTTCTGCAGGTTTTGAAGTGTCAGCTTCATAAGACACTGAGGTTTAGAATTGTTTGATTCTAGACCATAACTGAAGGGCAT
AAATGGAAACAGGATATGAAGGGAAACAAGTAGCATCATGGAGCTGAAAAGTGGTGCATCACCCAATGGCTAGCACAAACAAGGATCACA
CTGTCCATTCTCTTGTCTGCTAAATTAAGCATTTTCTTGCCTCCTTTGCTTCATCTTTTCACAACAGCTGGATAGAGGGATCAGAAATGA
CTGTGTCATGGTGCTCATTCACTGCAAACTCCCAGTTGCAAGCTCCTTGGCTCCCCCGGAGGGAGCAAGAATCTCATAGTTCAGAGACAC
AGAGGGCCTTTTAGCCCTAATGACCTTTTGGATGGGACTGCAACTCATGACTATCCTGATATTGGAAGAAAGGACTTTGTTAATCTTCTC
CCCCATAGCTCTGCTGCGTAGGTCTACATCTTACTCAGAATCACTACACATTCCTTTAGTCTTCCTCCAAGCTCCAGAGCCATTGGTACA
AATGCTTTATTGAAACTAAATACATAATACACACAATGAGATGAAGACAATATAGAAGTCCGCATAGTCATCATAATCCCGTTCCTTGGC
CGGTTGAGGCAGCTCAGTGGCTGAGCCCAGTCAAGCCAACCCGCAGCTTCACTCACGACTTCAAGATTTGATGCTAATTCTTTTGGATTT

>In-frame_ENST00000427699_ENST00000225972_5263N_ABCC3_chr17_48712342_+_LRRC59_chr17_48465493_length(amino acids)=186AA_start in transcript=59_stop in transcript=619
MQPRLGPMDALCGSGELGSKFWVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKR
EQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCC3-LRRC59


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC3-LRRC59


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC3-LRRC59


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC3C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC3C0008370Cholestasis1CTD_human
HgeneABCC3C0009402Colorectal Carcinoma1CTD_human
HgeneABCC3C0009404Colorectal Neoplasms1CTD_human
HgeneABCC3C0019209Hepatomegaly1CTD_human
TgeneLRRC59C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneLRRC59C0017636Glioblastoma1CTD_human
TgeneLRRC59C0024232Lymphatic Metastasis1CTD_human
TgeneLRRC59C0334588Giant Cell Glioblastoma1CTD_human
TgeneLRRC59C0919267ovarian neoplasm1CTD_human
TgeneLRRC59C1140680Malignant neoplasm of ovary1CTD_human
TgeneLRRC59C1621958Glioblastoma Multiforme1CTD_human
TgeneLRRC59C2239176Liver carcinoma1CTD_human