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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC3-XYLT2 (FusionGDB2 ID:392)

Fusion Gene Summary for ABCC3-XYLT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC3-XYLT2
Fusion gene ID: 392
HgeneTgene
Gene symbol

ABCC3

XYLT2

Gene ID

8714

64132

Gene nameATP binding cassette subfamily C member 3xylosyltransferase 2
SynonymsABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2PXYLT2|SOS|XT-II|XT2|xylT-II
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrugxylosyltransferase 2UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferasepeptide O-xylosyltransferase 1protein xylosyltransferase 2xylosyltransferase II
Modification date2020031320200313
UniProtAcc

O15438

.
Ensembl transtripts involved in fusion geneENST00000285238, ENST00000515707, 
ENST00000427699, ENST00000510891, 
ENST00000017003, ENST00000507602, 
Fusion gene scores* DoF score16 X 12 X 7=13444 X 3 X 4=48
# samples 185
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABCC3 [Title/Abstract] AND XYLT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC3(48755580)-XYLT2(48435568), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC3

GO:0042908

xenobiotic transport

18698235|19334674


check buttonFusion gene breakpoints across ABCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across XYLT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GH-01AABCC3chr17

48755580

+XYLT2chr17

48435568

+
ChimerDB4STADTCGA-HU-A4GHABCC3chr17

48755580

+XYLT2chr17

48435567

+
ChimerDB4STADTCGA-HU-A4GH-01AABCC3chr17

48755580

+XYLT2chr17

48435568

+
ChimerDB4STADTCGA-HU-A4GH-01AABCC3chr17

48755580

-XYLT2chr17

48435568

+


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Fusion Gene ORF analysis for ABCC3-XYLT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000285238ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
5CDS-intronENST00000285238ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-3CDSENST00000515707ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-intronENST00000515707ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-3CDSENST00000427699ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-intronENST00000427699ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-3CDSENST00000510891ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435568

+
intron-intronENST00000510891ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435568

+
In-frameENST00000285238ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435567

+
5CDS-intronENST00000285238ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435567

+
intron-3CDSENST00000515707ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435567

+
intron-intronENST00000515707ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435567

+
intron-3CDSENST00000427699ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435567

+
intron-intronENST00000427699ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435567

+
intron-3CDSENST00000510891ENST00000017003ABCC3chr17

48755580

+XYLT2chr17

48435567

+
intron-intronENST00000510891ENST00000507602ABCC3chr17

48755580

+XYLT2chr17

48435567

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285238ABCC3chr1748755580+ENST00000017003XYLT2chr1748435568+530237855944411460
ENST00000285238ABCC3chr1748755580+ENST00000017003XYLT2chr1748435567+530237855944411460

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285238ENST00000017003ABCC3chr1748755580+XYLT2chr1748435568+0.0020921410.9979079
ENST00000285238ENST00000017003ABCC3chr1748755580+XYLT2chr1748435567+0.0020921410.9979079

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Fusion Genomic Features for ABCC3-XYLT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC3chr1748755580+XYLT2chr1748435567+0.0036003840.99639964
ABCC3chr1748755580+XYLT2chr1748435567+0.0036003840.99639964
ABCC3chr1748755580+XYLT2chr1748435567+0.0036003840.99639964
ABCC3chr1748755580+XYLT2chr1748435567+0.0036003840.99639964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABCC3-XYLT2


check button Go to

FGviewer for the breakpoints of chr17:48755580-chr17:48435568

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC3

O15438

.
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531311_5941235.01528.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531629_8511235.01528.0DomainABC transporter 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531311_5941235.01528.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531629_8511235.01528.0DomainABC transporter 1
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531661_6681235.01528.0Nucleotide bindingATP 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531661_6681235.01528.0Nucleotide bindingATP 1
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311043_10851235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311107_11071235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311129_11991235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531121_1321235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311221_12221235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531154_1711235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531193_3021235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311_321235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531324_3491235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531371_4261235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531448_4501235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531472_5331235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+253154_731235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531555_5761235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531598_9631235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+253195_991235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531985_10211235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311043_10851235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311107_11071235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311129_11991235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531121_1321235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311221_12221235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531154_1711235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531193_3021235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311_321235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531324_3491235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531371_4261235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531448_4501235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531472_5331235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253154_731235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531555_5761235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531598_9631235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253195_991235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531985_10211235.01528.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531100_1201235.01528.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311022_10421235.01528.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311086_11061235.01528.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311108_11281235.01528.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311200_12201235.01528.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531133_1531235.01528.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531172_1921235.01528.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531303_3231235.01528.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+253133_531235.01528.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531350_3701235.01528.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531427_4471235.01528.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531451_4711235.01528.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531534_5541235.01528.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531577_5971235.01528.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+253174_941235.01528.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531964_9841235.01528.0TransmembraneHelical%3B Name%3D12
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531100_1201235.01528.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311022_10421235.01528.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311086_11061235.01528.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311108_11281235.01528.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311200_12201235.01528.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531133_1531235.01528.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531172_1921235.01528.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531303_3231235.01528.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253133_531235.01528.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531350_3701235.01528.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531427_4471235.01528.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531451_4711235.01528.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531534_5541235.01528.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531577_5971235.01528.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+253174_941235.01528.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531964_9841235.01528.0TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311291_15231235.01528.0DomainABC transporter 2
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+2531971_12521235.01528.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121291_15230573.0DomainABC transporter 2
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112311_5940573.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112629_8510573.0DomainABC transporter 1
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112971_12520573.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311291_15231235.01528.0DomainABC transporter 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+2531971_12521235.01528.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121291_15230573.0DomainABC transporter 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112311_5940573.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112629_8510573.0DomainABC transporter 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112971_12520573.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311323_13301235.01528.0Nucleotide bindingATP 2
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121323_13300573.0Nucleotide bindingATP 2
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112661_6680573.0Nucleotide bindingATP 1
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311323_13301235.01528.0Nucleotide bindingATP 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121323_13300573.0Nucleotide bindingATP 2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112661_6680573.0Nucleotide bindingATP 1
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311244_15271235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121043_10850573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121107_11070573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121129_11990573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112121_1320573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121221_12220573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121244_15270573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112154_1710573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112193_3020573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121_320573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112324_3490573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112371_4260573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112448_4500573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112472_5330573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+11254_730573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112555_5760573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112598_9630573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+11295_990573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112985_10210573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311244_15271235.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121043_10850573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121107_11070573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121129_11990573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112121_1320573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121221_12220573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121244_15270573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112154_1710573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112193_3020573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121_320573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112324_3490573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112371_4260573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112448_4500573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112472_5330573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11254_730573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112555_5760573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112598_9630573.0Topological domainCytoplasmic
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11295_990573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112985_10210573.0Topological domainExtracellular
HgeneABCC3chr17:48755580chr17:48435567ENST00000285238+25311223_12431235.01528.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112100_1200573.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121022_10420573.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121086_11060573.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121108_11280573.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121200_12200573.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+1121223_12430573.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112133_1530573.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112172_1920573.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112303_3230573.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+11233_530573.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112350_3700573.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112427_4470573.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112451_4710573.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112534_5540573.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112577_5970573.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+11274_940573.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48755580chr17:48435567ENST00000427699+112964_9840573.0TransmembraneHelical%3B Name%3D12
HgeneABCC3chr17:48755580chr17:48435568ENST00000285238+25311223_12431235.01528.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112100_1200573.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121022_10420573.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121086_11060573.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121108_11280573.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121200_12200573.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+1121223_12430573.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112133_1530573.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112172_1920573.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112303_3230573.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11233_530573.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112350_3700573.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112427_4470573.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112451_4710573.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112534_5540573.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112577_5970573.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+11274_940573.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48755580chr17:48435568ENST00000427699+112964_9840573.0TransmembraneHelical%3B Name%3D12
TgeneXYLT2chr17:48755580chr17:48435567ENST00000017003811296_298647.0866.0RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435567ENST00000017003811400_401647.0866.0RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435567ENST00000017003811504_505647.0866.0RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003811296_298647.0866.0RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003811400_401647.0866.0RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435568ENST00000017003811504_505647.0866.0RegionUDP-xylose binding
TgeneXYLT2chr17:48755580chr17:48435567ENST000000170038111_15647.0866.0Topological domainCytoplasmic
TgeneXYLT2chr17:48755580chr17:48435567ENST0000001700381137_865647.0866.0Topological domainLumenal
TgeneXYLT2chr17:48755580chr17:48435568ENST000000170038111_15647.0866.0Topological domainCytoplasmic
TgeneXYLT2chr17:48755580chr17:48435568ENST0000001700381137_865647.0866.0Topological domainLumenal
TgeneXYLT2chr17:48755580chr17:48435567ENST0000001700381116_36647.0866.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneXYLT2chr17:48755580chr17:48435568ENST0000001700381116_36647.0866.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ABCC3-XYLT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000285238_ENST00000017003_TCGA-HU-A4GH-01A_ABCC3_chr17_48755580_+_XYLT2_chr17_48435568_length(transcript)=5302nt_BP=3785nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCTGTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGA
ACTCCCTGCTGGCCTGGGTGCCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGTCGTGGCTACA
TCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTGTGGTGCGTCTCCTGGGCGGACCTTTTTTACTCCTTCCATG
GCCTGGTCCATGGCCGGGCCCCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACCCTGCTGATAC
AGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTCTGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCT
CCAAGATCCTTTTAGCCAAGGCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTGGTACTCTCTG
CCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAGAATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCT
TTCTCTCCCGCCTGTTTTTCTGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTCTGGTCCCTAA
AGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGGAGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAG
CAGCACCTGGGAAAAATGCCTCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTGAAGGCCCTGC
TGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATCCAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCA
TCCTGATCAGGTTTATCTCCAACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCCATGATGCAGT
CGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAGTTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTC
TGGTTATCACCAACTCAGTCAAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTCATGGACCTTG
CCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCGATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGG
CTGGAGTCGCTTTCATGGTCTTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAAATGAAATTGA
AGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTGCTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGG
TGGAGGGCATCAGGCAGGGTGAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATGTGCAGCCCCT
TCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAACAATGTGCTGGACGCCGAGAAGGCCTTTGTGTCTGTGTCCT
TGTTTAATATCTTAAGACTTCCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAACGGATCCAGC
AATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACCATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCT
TCACCTGGGCCCAGGACCTGCCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTGGGGCCTGTGG
GCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAGCTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATG
TGCCCCAGCAGGCATGGATCCAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTACCAGCAGACTC
TGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGATCAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGG
GCCAGCGGCAGCGGGTCAGTCTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCGGTGGACTCTC
ATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTGGCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCT
TCCTGCCCCAGACAGACTTCATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAGCGCAACGGCT
CCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCACCTGGAGGACAGCTGGACCGCGTTGGAAGGTGCAGAGGATA
AGGAGGCACTGCTGATTGAAGACACACTCAGCAACCACACGGATCTGACAGACAATGATCCAGTCACCTATGTGGTCCAGAAGCAGTTTA
TGAGACAGCTGAGTGCCCTGTCCTCAGATGGGGAGGGACAGGGTCGGCCTGTACCCCGGAGGCACCTGGGTCCATCAGAGAAGGTGCAGG
TGACAGAGGCGAAGGCAGATGGGGCACTGACCCAGGAGGAGAAAGCAGCCATTGGCACTGTGGAGCTCAGTGTGTTCTGGGATTATGCCA
AGGCCGTGGGGCTCTGTACCACGCTGGCCATCTGTCTCCTGTATGTGGGTCAAAGTGCGGCTGCCATTGGAGCCAATGTGTGGCTCAGTG
CCTGGACAAATGATGCCATGGCAGACAGTAGACAGAACAACACTTCCCTGAGGCTGGGCGTCTATGCTGCTTTAGGAATTCTGCAAGGGT
TCTTGGTGATGCTGGCAGCCATGGCCATGGCAGCGGGTGGCATCCAGGCTGCCCGTGTGTTGCACCAGGCACTGCTGCACAACAAGATAC
GCTCGCCACAGTCCTTCTTTGACACCACACCATCAGGCCGCATCCTGAACTGCTTCTCCAAGGACATCTATGTCGTTGATGAGGTTCTGG
CCCCTGTCATCCTCATGCTGCTCAATTCCTTCTTCAACGCCATCTCCACTCTTGTGGTCATCATGGCCAGCACGCCGCTCTTCACTGTGG
TCATCCTGCCCCTGGCTGTGCTCTACACCTTAGTGCAGCGCTTCTATGCAGCCACATCACGGCAACTGAAGCGGCTGGAATCAGTCAGCC
GCTCACCTATCTACTCCCACTTTTCGGAGACAGTGACTGGTGCCAGTGTCATCCGGGCCTACAACCGCAGCCGGGATTTTGAGATCATCA
GTGATACTAAGGTGGATGCCAACCAGAGAAGCTGCTACCCCTACATCATCTCCAACCGGTGGCTGAGCATCGGAGTGGAGTTCGTGGGGA
ACTGCGTGGTGCTCTTTGCTGCACTATTTGCCGTCATCGGGAGGAGCAGCCTGAACCCGGGGCTGGTGGGCCTTTCTGTGTCCTACTCCT
TGCAGGTTGGCACTGATTGGGACCCCAAAGAGCGTCTTTTCCGGAACTTTGGGGGGTTACTGGGGCCGCTGGACGAGCCTGTGGCCGTGC
AGCGCTGGGCCCGGGGCCCCAACCTCACAGCCACAGTGGTCTGGATCGACCCAACCTATGTGGTGGCCACATCTTATGACATCACAGTAG
ATACGGAGACTGAGGTCACGCAATACAAGCCCCCACTGAGCCGGCCCCTGCGGCCAGGGCCCTGGACTGTTCGACTCCTTCAGTTCTGGG
AACCGCTGGGTGAGACCCGCTTCCTTGTGCTGCCCTTGACCTTCAACCGCAAACTACCTCTCAGGAAAGATGATGCCAGCTGGCTGCACG
CAGGGCCACCCCACAACGAGTACATGGAGCAGAGTTTCCAGGGCCTGAGTAGCATCCTGAACCTGCCTCAGCCGGAGCTCGCGGAGGAGG
CTGCCCAGCGGCACACACAGCTCACAGGCCCTGCGCTCGAGGCCTGGACAGACAGGGAACTGAGCAGCTTCTGGTCCGTGGCTGGACTGT
GTGCCATAGGCCCCTCTCCCTGCCCCTCCCTGGAGCCCTGCAGACTGACCAGCTGGAGCTCTCTGTCCCCCGACCCCAAATCAGAGCTGG
GGCCTGTCAAAGCAGACGGGCGACTCAGGTAGCAGGGCCCCAGCCAGTACCCGTGGAGGACCCGGGAAATTGCACCTTACAGACAGTGGA
GGGGTGTCCCCTCCCACAGGCAAGAACCAGAGGCCCAGGCTGCACACCCATTTCAGCCATCAAGAACCCACACAGACGGCAGGGAAGGTG
GACACAGTATGAACTACTGCTGATGTCTCTGTTGGGGATCAGAGGGCTGGCGGGAACGCGAGAAGGGCACCAGCAGCATTCCACACCCAG
CTCTTCCTCACCTTCCTGTCTAGTTTGAATTTCTTTTTTTTCTTTTTTTTTTTTTTTTTTTAATTTAAAAAGGAAAATGGGTGGTTGGGA
GAGAAACTAGAACAGAAGATGTGCAATAGGGCTCAGAGCAGCCCCAGGAAGTGGGCCATGTCTGTGGGGAGCAGGGGCTTGCTGAGCCCA
CCTGCTATTGTTCTGCACGAGGCTGGGCCTGCCTCACTCTCCAGGGCCTCATGCCCCATTCTGGGCCTGTGGTGCTCGTGGCTGAGGCTC
CACAGGGCTGCAAGTGCCCTGCCAGGCTCTAAGGCCCGAAGAACAGGTGATATCGGGGGCGCTGCAGAGCTGGGCTCTAGCAGGACAGTT
CTTTTGTAGCCAGGGGACCCTAGAAGTGGGGTGGGGCGGCTCCAGGGCTTTCCAGCATACCCTGCCCCTGGATGGGAAAGGCAGGGTCAG
GGCCCACTGAGACCCATGCAGAGTTTCCAGGTGTGCACTGGAAGTGAGGTCACATGAGCAGCGTGGGAAGAAGACTCTGTCAAGACTCTC

>In-frame_ENST00000285238_ENST00000017003_TCGA-HU-A4GH-01A_ABCC3_chr17_48755580_+_XYLT2_chr17_48435568_length(amino acids)=1460AA_start in transcript=59_stop in transcript=4441
MQPRLGPMDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCV
SWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTT
FYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ
EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA
GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYF
LWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT
TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISP
GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGK
ALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGK
TRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDND
PVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA
AAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFS
KDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRA
YNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVGTDWDPKERLFRNFGGL
LGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLP
LRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWS

--------------------------------------------------------------
>In-frame_ENST00000285238_ENST00000017003_TCGA-HU-A4GH_ABCC3_chr17_48755580_+_XYLT2_chr17_48435567_length(transcript)=5302nt_BP=3785nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCTGTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGA
ACTCCCTGCTGGCCTGGGTGCCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGTCGTGGCTACA
TCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTGTGGTGCGTCTCCTGGGCGGACCTTTTTTACTCCTTCCATG
GCCTGGTCCATGGCCGGGCCCCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACCCTGCTGATAC
AGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTCTGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCT
CCAAGATCCTTTTAGCCAAGGCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTGGTACTCTCTG
CCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAGAATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCT
TTCTCTCCCGCCTGTTTTTCTGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTCTGGTCCCTAA
AGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGGAGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAG
CAGCACCTGGGAAAAATGCCTCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTGAAGGCCCTGC
TGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATCCAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCA
TCCTGATCAGGTTTATCTCCAACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCCATGATGCAGT
CGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAGTTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTC
TGGTTATCACCAACTCAGTCAAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTCATGGACCTTG
CCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCGATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGG
CTGGAGTCGCTTTCATGGTCTTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAAATGAAATTGA
AGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTGCTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGG
TGGAGGGCATCAGGCAGGGTGAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATGTGCAGCCCCT
TCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAACAATGTGCTGGACGCCGAGAAGGCCTTTGTGTCTGTGTCCT
TGTTTAATATCTTAAGACTTCCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAACGGATCCAGC
AATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACCATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCT
TCACCTGGGCCCAGGACCTGCCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTGGGGCCTGTGG
GCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAGCTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATG
TGCCCCAGCAGGCATGGATCCAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTACCAGCAGACTC
TGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGATCAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGG
GCCAGCGGCAGCGGGTCAGTCTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCGGTGGACTCTC
ATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTGGCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCT
TCCTGCCCCAGACAGACTTCATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAGCGCAACGGCT
CCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCACCTGGAGGACAGCTGGACCGCGTTGGAAGGTGCAGAGGATA
AGGAGGCACTGCTGATTGAAGACACACTCAGCAACCACACGGATCTGACAGACAATGATCCAGTCACCTATGTGGTCCAGAAGCAGTTTA
TGAGACAGCTGAGTGCCCTGTCCTCAGATGGGGAGGGACAGGGTCGGCCTGTACCCCGGAGGCACCTGGGTCCATCAGAGAAGGTGCAGG
TGACAGAGGCGAAGGCAGATGGGGCACTGACCCAGGAGGAGAAAGCAGCCATTGGCACTGTGGAGCTCAGTGTGTTCTGGGATTATGCCA
AGGCCGTGGGGCTCTGTACCACGCTGGCCATCTGTCTCCTGTATGTGGGTCAAAGTGCGGCTGCCATTGGAGCCAATGTGTGGCTCAGTG
CCTGGACAAATGATGCCATGGCAGACAGTAGACAGAACAACACTTCCCTGAGGCTGGGCGTCTATGCTGCTTTAGGAATTCTGCAAGGGT
TCTTGGTGATGCTGGCAGCCATGGCCATGGCAGCGGGTGGCATCCAGGCTGCCCGTGTGTTGCACCAGGCACTGCTGCACAACAAGATAC
GCTCGCCACAGTCCTTCTTTGACACCACACCATCAGGCCGCATCCTGAACTGCTTCTCCAAGGACATCTATGTCGTTGATGAGGTTCTGG
CCCCTGTCATCCTCATGCTGCTCAATTCCTTCTTCAACGCCATCTCCACTCTTGTGGTCATCATGGCCAGCACGCCGCTCTTCACTGTGG
TCATCCTGCCCCTGGCTGTGCTCTACACCTTAGTGCAGCGCTTCTATGCAGCCACATCACGGCAACTGAAGCGGCTGGAATCAGTCAGCC
GCTCACCTATCTACTCCCACTTTTCGGAGACAGTGACTGGTGCCAGTGTCATCCGGGCCTACAACCGCAGCCGGGATTTTGAGATCATCA
GTGATACTAAGGTGGATGCCAACCAGAGAAGCTGCTACCCCTACATCATCTCCAACCGGTGGCTGAGCATCGGAGTGGAGTTCGTGGGGA
ACTGCGTGGTGCTCTTTGCTGCACTATTTGCCGTCATCGGGAGGAGCAGCCTGAACCCGGGGCTGGTGGGCCTTTCTGTGTCCTACTCCT
TGCAGGTTGGCACTGATTGGGACCCCAAAGAGCGTCTTTTCCGGAACTTTGGGGGGTTACTGGGGCCGCTGGACGAGCCTGTGGCCGTGC
AGCGCTGGGCCCGGGGCCCCAACCTCACAGCCACAGTGGTCTGGATCGACCCAACCTATGTGGTGGCCACATCTTATGACATCACAGTAG
ATACGGAGACTGAGGTCACGCAATACAAGCCCCCACTGAGCCGGCCCCTGCGGCCAGGGCCCTGGACTGTTCGACTCCTTCAGTTCTGGG
AACCGCTGGGTGAGACCCGCTTCCTTGTGCTGCCCTTGACCTTCAACCGCAAACTACCTCTCAGGAAAGATGATGCCAGCTGGCTGCACG
CAGGGCCACCCCACAACGAGTACATGGAGCAGAGTTTCCAGGGCCTGAGTAGCATCCTGAACCTGCCTCAGCCGGAGCTCGCGGAGGAGG
CTGCCCAGCGGCACACACAGCTCACAGGCCCTGCGCTCGAGGCCTGGACAGACAGGGAACTGAGCAGCTTCTGGTCCGTGGCTGGACTGT
GTGCCATAGGCCCCTCTCCCTGCCCCTCCCTGGAGCCCTGCAGACTGACCAGCTGGAGCTCTCTGTCCCCCGACCCCAAATCAGAGCTGG
GGCCTGTCAAAGCAGACGGGCGACTCAGGTAGCAGGGCCCCAGCCAGTACCCGTGGAGGACCCGGGAAATTGCACCTTACAGACAGTGGA
GGGGTGTCCCCTCCCACAGGCAAGAACCAGAGGCCCAGGCTGCACACCCATTTCAGCCATCAAGAACCCACACAGACGGCAGGGAAGGTG
GACACAGTATGAACTACTGCTGATGTCTCTGTTGGGGATCAGAGGGCTGGCGGGAACGCGAGAAGGGCACCAGCAGCATTCCACACCCAG
CTCTTCCTCACCTTCCTGTCTAGTTTGAATTTCTTTTTTTTCTTTTTTTTTTTTTTTTTTTAATTTAAAAAGGAAAATGGGTGGTTGGGA
GAGAAACTAGAACAGAAGATGTGCAATAGGGCTCAGAGCAGCCCCAGGAAGTGGGCCATGTCTGTGGGGAGCAGGGGCTTGCTGAGCCCA
CCTGCTATTGTTCTGCACGAGGCTGGGCCTGCCTCACTCTCCAGGGCCTCATGCCCCATTCTGGGCCTGTGGTGCTCGTGGCTGAGGCTC
CACAGGGCTGCAAGTGCCCTGCCAGGCTCTAAGGCCCGAAGAACAGGTGATATCGGGGGCGCTGCAGAGCTGGGCTCTAGCAGGACAGTT
CTTTTGTAGCCAGGGGACCCTAGAAGTGGGGTGGGGCGGCTCCAGGGCTTTCCAGCATACCCTGCCCCTGGATGGGAAAGGCAGGGTCAG
GGCCCACTGAGACCCATGCAGAGTTTCCAGGTGTGCACTGGAAGTGAGGTCACATGAGCAGCGTGGGAAGAAGACTCTGTCAAGACTCTC

>In-frame_ENST00000285238_ENST00000017003_TCGA-HU-A4GH_ABCC3_chr17_48755580_+_XYLT2_chr17_48435567_length(amino acids)=1460AA_start in transcript=59_stop in transcript=4441
MQPRLGPMDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCV
SWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTT
FYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ
EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA
GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYF
LWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT
TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISP
GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGK
ALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGK
TRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDND
PVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA
AAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFS
KDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRA
YNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVGTDWDPKERLFRNFGGL
LGPLDEPVAVQRWARGPNLTATVVWIDPTYVVATSYDITVDTETEVTQYKPPLSRPLRPGPWTVRLLQFWEPLGETRFLVLPLTFNRKLP
LRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQPELAEEAAQRHTQLTGPALEAWTDRELSSFWSVAGLCAIGPSPCPSLEPCRLTSWS

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Fusion Gene PPI Analysis for ABCC3-XYLT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC3-XYLT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC3-XYLT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC3C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC3C0008370Cholestasis1CTD_human
HgeneABCC3C0009402Colorectal Carcinoma1CTD_human
HgeneABCC3C0009404Colorectal Neoplasms1CTD_human
HgeneABCC3C0019209Hepatomegaly1CTD_human
TgeneXYLT2C4225412Spondylo-ocular syndrome3GENOMICS_ENGLAND
TgeneXYLT2C0033847Pseudoxanthoma Elasticum1CTD_human;UNIPROT
TgeneXYLT2C0376359Gronblad-Strandberg Syndrome1CTD_human
TgeneXYLT2C1853925Spondyloocular Syndrome, Autosomal Recessive1ORPHANET
TgeneXYLT2C1867450Pseudoxanthoma Elasticum, Incomplete1CTD_human