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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:IKBKG-ATP2B3 (FusionGDB2 ID:39214) |
Fusion Gene Summary for IKBKG-ATP2B3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: IKBKG-ATP2B3 | Fusion gene ID: 39214 | Hgene | Tgene | Gene symbol | IKBKG | ATP2B3 | Gene ID | 8517 | 492 |
Gene name | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma | ATPase plasma membrane Ca2+ transporting 3 | |
Synonyms | AMCBX1|EDAID1|FIP-3|FIP3|Fip3p|IKK-gamma|IKKAP1|IKKG|IMD33|IP|IP1|IP2|IPD2|NEMO|ZC2HC9 | CFAP39|CLA2|OPCA|PMCA3|PMCA3a|SCAX1 | |
Cytomap | Xq28 | Xq28 | |
Type of gene | protein-coding | protein-coding | |
Description | NF-kappa-B essential modulatorI-kappa-B kinase subunit gammaNF-kappa-B essential modifierikB kinase subunit gammaikB kinase-associated protein 1incontinentia pigmentiinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammainhibit | plasma membrane calcium-transporting ATPase 3ATPase, Ca++ transporting, plasma membrane 3cilia and flagella associated protein 39plasma membrane calcium ATPaseplasma membrane calcium pump | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | Q9Y6K9 | Q16720 | |
Ensembl transtripts involved in fusion gene | ENST00000369609, ENST00000369607, ENST00000369606, ENST00000263518, ENST00000470142, ENST00000393549, ENST00000455588, ENST00000369602, ENST00000369601, ENST00000492469, | ENST00000349466, ENST00000370186, ENST00000393842, ENST00000359149, ENST00000263519, ENST00000370181, ENST00000460549, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 5 X 3=45 |
# samples | 5 | 5 | |
** MAII score | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: IKBKG [Title/Abstract] AND ATP2B3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | IKBKG(153775960)-ATP2B3(152806816), # samples:1 IKBKG(153775960)-ATP2B3(152806817), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IKBKG | GO:0006974 | cellular response to DNA damage stimulus | 14651848 |
Hgene | IKBKG | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 17702576 |
Hgene | IKBKG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055 |
Hgene | IKBKG | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15620648 |
Hgene | IKBKG | GO:0065003 | protein-containing complex assembly | 11113112 |
Tgene | ATP2B3 | GO:0051480 | regulation of cytosolic calcium ion concentration | 18029012 |
Tgene | ATP2B3 | GO:1990034 | calcium ion export across plasma membrane | 18029012 |
Fusion gene breakpoints across IKBKG (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ATP2B3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-FI-A2CY | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
ChimerDB4 | UCEC | TCGA-FI-A2CY-01A | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
Top |
Fusion Gene ORF analysis for IKBKG-ATP2B3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000369609 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369609 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369609 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369609 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369609 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369609 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-intron | ENST00000369609 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369607 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369607 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369607 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369607 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369607 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369607 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-intron | ENST00000369607 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369606 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369606 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369606 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369606 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369606 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369606 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-intron | ENST00000369606 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000263518 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000263518 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000263518 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000263518 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000263518 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000263518 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-intron | ENST00000263518 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000470142 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000470142 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000470142 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000470142 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000470142 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000470142 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-intron | ENST00000470142 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000393549 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000393549 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000393549 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000393549 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000393549 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000393549 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-intron | ENST00000393549 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000455588 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000455588 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000455588 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000455588 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000455588 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000455588 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-intron | ENST00000455588 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369602 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369602 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369602 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369602 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369602 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-3CDS | ENST00000369602 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
5UTR-intron | ENST00000369602 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369601 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369601 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369601 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369601 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369601 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369601 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-intron | ENST00000369601 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000492469 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000492469 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000492469 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000492469 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000492469 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000492469 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-intron | ENST00000492469 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + |
intron-3CDS | ENST00000369609 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369609 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369609 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369609 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369609 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369609 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-intron | ENST00000369609 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369607 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369607 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369607 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369607 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369607 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369607 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-intron | ENST00000369607 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369606 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369606 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369606 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369606 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369606 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369606 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-intron | ENST00000369606 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000263518 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000263518 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000263518 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000263518 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000263518 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000263518 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-intron | ENST00000263518 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000470142 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000470142 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000470142 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000470142 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000470142 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000470142 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-intron | ENST00000470142 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000393549 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000393549 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000393549 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000393549 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000393549 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000393549 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-intron | ENST00000393549 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000455588 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000455588 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000455588 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000455588 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000455588 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000455588 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-intron | ENST00000455588 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369602 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369602 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369602 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369602 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369602 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-3CDS | ENST00000369602 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
5UTR-intron | ENST00000369602 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369601 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369601 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369601 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369601 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369601 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000369601 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-intron | ENST00000369601 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000492469 | ENST00000349466 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000492469 | ENST00000370186 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000492469 | ENST00000393842 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000492469 | ENST00000359149 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000492469 | ENST00000263519 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-3CDS | ENST00000492469 | ENST00000370181 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
intron-intron | ENST00000492469 | ENST00000460549 | IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806817 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for IKBKG-ATP2B3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + | 5.79E-06 | 0.99999416 |
IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + | 5.79E-06 | 0.99999416 |
IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + | 5.79E-06 | 0.99999416 |
IKBKG | chrX | 153775960 | + | ATP2B3 | chrX | 152806816 | + | 5.79E-06 | 0.99999416 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IKBKG-ATP2B3 |
Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
IKBKG | ATP2B3 |
FUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660}. | FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for IKBKG-ATP2B3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for IKBKG-ATP2B3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IKBKG-ATP2B3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IKBKG-ATP2B3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IKBKG | C0021171 | Bloch Sulzberger syndrome | 10 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | IKBKG | C1846008 | HYPER-IgM IMMUNODEFICIENCY, X-LINKED, WITH ECTODERMAL DYSPLASIA, HYPOHIDROTIC | 10 | GENOMICS_ENGLAND;UNIPROT |
Hgene | IKBKG | C1845117 | Immunodeficiency without anhidrotic ectodermal dysplasia | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | IKBKG | C1970879 | ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | IKBKG | C1845919 | Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | IKBKG | C1845073 | INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | IKBKG | C0019207 | Hepatoma, Morris | 1 | CTD_human |
Hgene | IKBKG | C0019208 | Hepatoma, Novikoff | 1 | CTD_human |
Hgene | IKBKG | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | IKBKG | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Hgene | IKBKG | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | IKBKG | C0086404 | Experimental Hepatoma | 1 | CTD_human |
Hgene | IKBKG | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | IKBKG | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
Hgene | IKBKG | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
Tgene | ATP2B3 | C0001430 | Adenoma | 1 | CTD_human |
Tgene | ATP2B3 | C0020428 | Hyperaldosteronism | 1 | CTD_human |
Tgene | ATP2B3 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | ATP2B3 | C0205646 | Adenoma, Basal Cell | 1 | CTD_human |
Tgene | ATP2B3 | C0205647 | Follicular adenoma | 1 | CTD_human |
Tgene | ATP2B3 | C0205648 | Adenoma, Microcystic | 1 | CTD_human |
Tgene | ATP2B3 | C0205649 | Adenoma, Monomorphic | 1 | CTD_human |
Tgene | ATP2B3 | C0205650 | Papillary adenoma | 1 | CTD_human |
Tgene | ATP2B3 | C0205651 | Adenoma, Trabecular | 1 | CTD_human |
Tgene | ATP2B3 | C0796205 | SPINOCEREBELLAR ATAXIA, X-LINKED 1 | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | ATP2B3 | C1384514 | Conn Syndrome | 1 | CTD_human |