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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL6ST-LAMC2 (FusionGDB2 ID:39414)

Fusion Gene Summary for IL6ST-LAMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: IL6ST-LAMC2
Fusion gene ID: 39414
HgeneTgene
Gene symbol

IL6ST

LAMC2

Gene ID

3572

3918

Gene nameinterleukin 6 signal transducerlaminin subunit gamma 2
SynonymsCD130|CDW130|GP130|HIES4|IL-6RB|sGP130B2T|BM600|CSF|EBR2|EBR2A|LAMB2T|LAMNB2
Cytomap

5q11.2

1q25.3

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-6 receptor subunit betaCD130 antigenIL-6 receptor subunit betaIL-6R subunit betagp130 of the rheumatoid arthritis antigenic peptide-bearing soluble formgp130, oncostatin M receptorinterleukin receptor beta chainmembrane glycoprotein 130laminin subunit gamma-2BM600-100kDaCSF 140 kDa subunitcell-scattering factor 140 kDa subunitepiligrin subunit gammakalinin subunit gammaladsin 140 kDa subunitlaminin B2t chainlaminin, gamma 2large adhesive scatter factor 140 kDa subunitnicein su
Modification date2020032720200315
UniProtAcc.

Q13753

Ensembl transtripts involved in fusion geneENST00000381298, ENST00000336909, 
ENST00000381287, ENST00000502326, 
ENST00000381294, ENST00000536319, 
ENST00000381293, ENST00000381286, 
ENST00000522633, ENST00000396816, 
ENST00000577363, 		ENST00000493293, 
ENST00000264144, ENST00000461729, 
Fusion gene scores* DoF score16 X 11 X 5=8806 X 5 X 4=120
# samples 196
** MAII scorelog2(19/880*10)=-2.21150410519371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL6ST [Title/Abstract] AND LAMC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL6ST(55247292)-LAMC2(183177016), # samples:3
Anticipated loss of major functional domain due to fusion event.IL6ST-LAMC2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
IL6ST-LAMC2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL6ST

GO:0008284

positive regulation of cell proliferation

2261637

HgeneIL6ST

GO:0019221

cytokine-mediated signaling pathway

2261637

HgeneIL6ST

GO:0034097

response to cytokine

2261637|8999038

HgeneIL6ST

GO:0048861

leukemia inhibitory factor signaling pathway

8999038|12643274

HgeneIL6ST

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway

12643274


check buttonFusion gene breakpoints across IL6ST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LAMC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A9WL-01AIL6STchr5

55247292

-LAMC2chr1

183177016

+
ChimerDB4PRADTCGA-YL-A9WLIL6STchr5

55247292

-LAMC2chr1

183177016

+
ChimerDB4PRADTCGA-YL-A9WL-01AIL6STchr5

55247292

-LAMC2chr1

183177016

+


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Fusion Gene ORF analysis for IL6ST-LAMC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000381298ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
In-frameENST00000381298ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
5CDS-intronENST00000381298ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
In-frameENST00000336909ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
In-frameENST00000336909ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
5CDS-intronENST00000336909ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-3CDSENST00000381287ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-3CDSENST00000381287ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-intronENST00000381287ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
Frame-shiftENST00000502326ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
Frame-shiftENST00000502326ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
5CDS-intronENST00000502326ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
In-frameENST00000381294ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
In-frameENST00000381294ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
5CDS-intronENST00000381294ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-3CDSENST00000536319ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-3CDSENST00000536319ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-intronENST00000536319ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000381293ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000381293ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-intronENST00000381293ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000381286ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000381286ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-intronENST00000381286ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-3CDSENST00000522633ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-3CDSENST00000522633ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
3UTR-intronENST00000522633ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000396816ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000396816ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-intronENST00000396816ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000577363ENST00000493293IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-3CDSENST00000577363ENST00000264144IL6STchr5

55247292

-LAMC2chr1

183177016

+
intron-intronENST00000577363ENST00000461729IL6STchr5

55247292

-LAMC2chr1

183177016

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381298IL6STchr555247292-ENST00000493293LAMC2chr1183177016+6272215331354091698
ENST00000381298IL6STchr555247292-ENST00000264144LAMC2chr1183177016+7156215331356551780
ENST00000336909IL6STchr555247292-ENST00000493293LAMC2chr1183177016+59951876651321708
ENST00000336909IL6STchr555247292-ENST00000264144LAMC2chr1183177016+68791876653781790
ENST00000381294IL6STchr555247292-ENST00000493293LAMC2chr1183177016+57761657049131637
ENST00000381294IL6STchr555247292-ENST00000264144LAMC2chr1183177016+66601657051591719

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381298ENST00000493293IL6STchr555247292-LAMC2chr1183177016+0.0005042350.99949574
ENST00000381298ENST00000264144IL6STchr555247292-LAMC2chr1183177016+0.0008865830.9991134
ENST00000336909ENST00000493293IL6STchr555247292-LAMC2chr1183177016+0.0003746270.9996253
ENST00000336909ENST00000264144IL6STchr555247292-LAMC2chr1183177016+0.00063080.9993692
ENST00000381294ENST00000493293IL6STchr555247292-LAMC2chr1183177016+0.0004355550.99956447
ENST00000381294ENST00000264144IL6STchr555247292-LAMC2chr1183177016+0.0007009340.99929905

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Fusion Genomic Features for IL6ST-LAMC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IL6STchr555247291-LAMC2chr1183177015+2.61E-060.9999974
IL6STchr555247291-LAMC2chr1183177015+2.61E-060.9999974
IL6STchr555247291-LAMC2chr1183177015+2.61E-060.9999974
IL6STchr555247291-LAMC2chr1183177015+2.61E-060.9999974

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL6ST-LAMC2


check button Go to

FGviewer for the breakpoints of chr5:55247292-chr1:183177016

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LAMC2

Q13753

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. {ECO:0000269|PubMed:8265624}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213725_755585.6666666666666299.3333333333333Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013725_755524.6666666666666441.3333333333333Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215125_216613.3333333333334919.0DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215224_324613.3333333333334919.0DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-121526_120613.3333333333334919.0DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215329_424613.3333333333334919.0DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215426_517613.3333333333334919.0DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215518_613613.3333333333334919.0DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114125_216585.66666666666662415.0DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114224_324585.66666666666662415.0DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-111426_120585.66666666666662415.0DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114329_424585.66666666666662415.0DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114426_517585.66666666666662415.0DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114125_216552.3333333333334858.0DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114224_324552.3333333333334858.0DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-111426_120552.3333333333334858.0DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114329_424552.3333333333334858.0DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114426_517552.3333333333334858.0DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417125_216613.3333333333334919.0DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417224_324613.3333333333334919.0DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-141726_120613.3333333333334919.0DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417329_424613.3333333333334919.0DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417426_517613.3333333333334919.0DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417518_613613.3333333333334919.0DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316125_216613.3333333333334919.0DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316224_324613.3333333333334919.0DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-131626_120613.3333333333334919.0DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316329_424613.3333333333334919.0DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316426_517613.3333333333334919.0DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316518_613613.3333333333334919.0DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213125_216585.6666666666666299.3333333333333DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213224_324585.6666666666666299.3333333333333DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-121326_120585.6666666666666299.3333333333333DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213329_424585.6666666666666299.3333333333333DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213426_517585.6666666666666299.3333333333333DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213518_613585.6666666666666299.3333333333333DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013125_216524.6666666666666441.3333333333333DomainFibronectin type-III 1
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013224_324524.6666666666666441.3333333333333DomainFibronectin type-III 2
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-101326_120524.6666666666666441.3333333333333DomainNote=Ig-like C2-type
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013329_424524.6666666666666441.3333333333333DomainFibronectin type-III 3
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013426_517524.6666666666666441.3333333333333DomainFibronectin type-III 4
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013518_613524.6666666666666441.3333333333333DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215310_314613.3333333333334919.0MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114310_314585.66666666666662415.0MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114310_314552.3333333333334858.0MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417310_314613.3333333333334919.0MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316310_314613.3333333333334919.0MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213310_314585.6666666666666299.3333333333333MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213651_659585.6666666666666299.3333333333333MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013310_314524.6666666666666441.3333333333333MotifNote=WSXWS motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013651_659524.6666666666666441.3333333333333MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-121323_619585.6666666666666299.3333333333333Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213642_918585.6666666666666299.3333333333333Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-101323_619524.6666666666666441.3333333333333Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013642_918524.6666666666666441.3333333333333Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000522633-1213620_641585.6666666666666299.3333333333333TransmembraneHelical
HgeneIL6STchr5:55247292chr1:183177016ENST00000536319-1013620_641524.6666666666666441.3333333333333TransmembraneHelical
TgeneLAMC2chr5:55247292chr1:183177016ENST000002641440231117_119326.3333333333333321194.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023611_71826.3333333333333321194.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023811_107626.3333333333333321194.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC2chr5:55247292chr1:183177016ENST000004932930221117_119326.3333333333333321112.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022611_71826.3333333333333321112.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022811_107626.3333333333333321112.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023139_18626.3333333333333321194.0DomainLaminin EGF-like 3
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023187_19626.3333333333333321194.0DomainLaminin EGF-like 4%3B first part
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023213_38126.3333333333333321194.0DomainLaminin IV type A
TgeneLAMC2chr5:55247292chr1:183177016ENST0000026414402328_8326.3333333333333321194.0DomainLaminin EGF-like 1
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023382_41526.3333333333333321194.0DomainLaminin EGF-like 4%3B second part
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023416_46126.3333333333333321194.0DomainLaminin EGF-like 5
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023462_51626.3333333333333321194.0DomainLaminin EGF-like 6
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023517_57226.3333333333333321194.0DomainLaminin EGF-like 7
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023573_60226.3333333333333321194.0DomainLaminin EGF-like 8%3B truncated
TgeneLAMC2chr5:55247292chr1:183177016ENST0000026414402384_13026.3333333333333321194.0DomainLaminin EGF-like 2
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022139_18626.3333333333333321112.0DomainLaminin EGF-like 3
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022187_19626.3333333333333321112.0DomainLaminin EGF-like 4%3B first part
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022213_38126.3333333333333321112.0DomainLaminin IV type A
TgeneLAMC2chr5:55247292chr1:183177016ENST0000049329302228_8326.3333333333333321112.0DomainLaminin EGF-like 1
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022382_41526.3333333333333321112.0DomainLaminin EGF-like 4%3B second part
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022416_46126.3333333333333321112.0DomainLaminin EGF-like 5
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022462_51626.3333333333333321112.0DomainLaminin EGF-like 6
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022517_57226.3333333333333321112.0DomainLaminin EGF-like 7
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022573_60226.3333333333333321112.0DomainLaminin EGF-like 8%3B truncated
TgeneLAMC2chr5:55247292chr1:183177016ENST0000049329302284_13026.3333333333333321112.0DomainLaminin EGF-like 2
TgeneLAMC2chr5:55247292chr1:183177016ENST00000264144023603_119326.3333333333333321194.0RegionNote=Domain II and I
TgeneLAMC2chr5:55247292chr1:183177016ENST00000493293022603_119326.3333333333333321112.0RegionNote=Domain II and I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215725_755613.3333333333334919.0Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114725_755585.66666666666662415.0Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114725_755552.3333333333334858.0Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417725_755613.3333333333334919.0Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316725_755613.3333333333334919.0Compositional biasNote=Ser-rich
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114518_613585.66666666666662415.0DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114518_613552.3333333333334858.0DomainFibronectin type-III 5
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215651_659613.3333333333334919.0MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114651_659585.66666666666662415.0MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114651_659552.3333333333334858.0MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417651_659613.3333333333334919.0MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316651_659613.3333333333334919.0MotifNote=Box 1 motif
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-121523_619613.3333333333334919.0Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215642_918613.3333333333334919.0Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-111423_619585.66666666666662415.0Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114642_918585.66666666666662415.0Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-111423_619552.3333333333334858.0Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114642_918552.3333333333334858.0Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-141723_619613.3333333333334919.0Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417642_918613.3333333333334919.0Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-131623_619613.3333333333334919.0Topological domainExtracellular
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316642_918613.3333333333334919.0Topological domainCytoplasmic
HgeneIL6STchr5:55247292chr1:183177016ENST00000336909-1215620_641613.3333333333334919.0TransmembraneHelical
HgeneIL6STchr5:55247292chr1:183177016ENST00000381287-1114620_641585.66666666666662415.0TransmembraneHelical
HgeneIL6STchr5:55247292chr1:183177016ENST00000381294-1114620_641552.3333333333334858.0TransmembraneHelical
HgeneIL6STchr5:55247292chr1:183177016ENST00000381298-1417620_641613.3333333333334919.0TransmembraneHelical
HgeneIL6STchr5:55247292chr1:183177016ENST00000502326-1316620_641613.3333333333334919.0TransmembraneHelical


Top

Fusion Gene Sequence for IL6ST-LAMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000381298_ENST00000493293_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(transcript)=6272nt_BP=2153nt
ACTGGGGTGGCGCGCTACCTCTGCGGAGAAGGATCTGACAGTGTTCCGGAGCCGGGGCGAGCAGCCAAAAGGCCCGCGGAGTCGCGCTGG
GCCGCCCCGGCGCAGCTGAACCGGGGGCCGCGCCTGCCAGGCCGACGGGTCTGGCCCAGCCTGGCGCCAAGGGGTTCGTGCGCTGTGGAG
ACGCGGAGGGTCGAGGCGGCGCGGCCTGAGTGAAACCCAATGGAAAAAGCATGACATTTAGAAGTAGAAGACTTAGCTTCAAATCCCTAC
TCCTTCACTTACTAATTTTGTGATTTGGAAATATCCGCGCAAGATGTTGACGTTGCAGACTTGGCTAGTGCAAGCCTTGTTTATTTTCCT
CACCACTGAATCTACAGGTGAACTTCTAGATCCATGTGGTTATATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGC
AGTTTGTGTGCTAAAGGAAAAATGTATGGATTATTTTCATGTAAATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAA
GGAGCAATATACTATCATAAACAGAACAGCATCCAGTGTCACCTTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCT
TACATTCGGACAGCTTGAACAGAATGTTTATGGAATCACAATAATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGT
GAACGAGGGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGGGAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAAC
ACACAAGTTTGCTGATTGCAAAGCAAAACGTGACACCCCCACCTCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGT
CTGGGTAGAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGATCATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACA
TAATTTATCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTAAAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAA
ATATAACATTCAATATAGGACCAAAGATGCCTCAACTTGGAGCCAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGT
CCAAGACCTTAAACCTTTTACAGAATATGTGTTTAGGATTCGCTGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGA
AGCAAGTGGGATCACCTATGAAGATAGACCATCTAAAGCACCAAGTTTCTGGTATAAAATAGATCCATCCCATACTCAAGGCTACAGAAC
TGTACAACTCGTGTGGAAGACATTGCCTCCTTTTGAAGCCAATGGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACA
TTTACAAAATTACACAGTTAATGCCACAAAACTGACAGTAAATCTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGT
TGGCAAATCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGACTTTCAAGCTACTCACCCTGTAATGGATCTTAAAGCATTCCCCAAAGA
TAACATGCTTTGGGTGGAATGGACTACTCCAAGGGAATCTGTAAAGAAATATATACTTGAGTGGTGTGTGTTATCAGATAAAGCACCCTG
TATCACAGACTGGCAACAAGAAGATGGTACCGTGCATCGCACCTATTTAAGAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGT
TACTCCAGTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAGGCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCG
GACAAAAAAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAACTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTAT
ATTTTATAGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGATTCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACAC
ATTGTACATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAGGATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGTCTGTGA
TTGCAATGGGAAGTCCAGGCAGTGTATCTTTGATCGGGAACTTCACAGACAAACTGGTAATGGATTCCGCTGCCTCAACTGCAATGACAA
CACTGATGGCATTCACTGCGAGAAGTGCAAGAATGGCTTTTACCGGCACAGAGAAAGGGACCGCTGTTTGCCCTGCAATTGTAACTCCAA
AGGTTCTCTTAGTGCTCGATGTGACAACTCCGGACGGTGCAGCTGTAAACCAGGTGTGACAGGAGCCAGATGCGACCGATGTCTGCCAGG
CTTCCACATGCTCACGGATGCGGGGTGCACCCAAGACCAGAGACTGCTAGACTCCAAGTGTGACTGTGACCCAGCTGGCATCGCAGGGCC
CTGTGACGCGGGCCGCTGTGTCTGCAAGCCAGCTGTCACTGGAGAACGCTGTGATAGGTGTCGATCAGGTTACTATAATCTGGATGGGGG
GAACCCTGAGGGCTGTACCCAGTGTTTCTGCTATGGGCATTCAGCCAGCTGCCGCAGCTCTGCAGAATACAGTGTCCATAAGATCACCTC
TACCTTTCATCAAGATGTTGATGGCTGGAAGGCTGTCCAACGAAATGGGTCTCCTGCAAAGCTCCAATGGTCACAGCGCCATCAAGATGT
GTTTAGCTCAGCCCAACGACTAGACCCTGTCTATTTTGTGGCTCCTGCCAAATTTCTTGGGAATCAACAGGTGAGCTATGGTCAAAGCCT
GTCCTTTGACTACCGTGTGGACAGAGGAGGCAGACACCCATCTGCCCATGATGTGATTCTGGAAGGTGCTGGTCTACGGATCACAGCTCC
CTTGATGCCACTTGGCAAGACACTGCCTTGTGGGCTCACCAAGACTTACACATTCAGGTTAAATGAGCATCCAAGCAATAATTGGAGCCC
CCAGCTGAGTTACTTTGAGTATCGAAGGTTACTGCGGAATCTCACAGCCCTCCGCATCCGAGCTACATATGGAGAATACAGTACTGGGTA
CATTGACAATGTGACCCTGATTTCAGCCCGCCCTGTCTCTGGAGCCCCAGCACCCTGGGTTGAACAGTGTATATGTCCTGTTGGGTACAA
GGGGCAATTCTGCCAGGATTGTGCTTCTGGCTACAAGAGAGATTCAGCGAGACTGGGGCCTTTTGGCACCTGTATTCCTTGTAACTGTCA
AGGGGGAGGGGCCTGTGATCCAGACACAGGAGATTGTTATTCAGGGGATGAGAATCCTGACATTGAGTGTGCTGACTGCCCAATTGGTTT
CTACAACGATCCGCACGACCCCCGCAGCTGCAAGCCATGTCCCTGTCATAACGGGTTCAGCTGCTCAGTGATGCCGGAGACGGAGGAGGT
GGTGTGCAATAACTGCCCTCCCGGGGTCACCGGTGCCCGCTGTGAGCTCTGTGCTGATGGCTACTTTGGGGACCCCTTTGGTGAACATGG
CCCAGTGAGGCCTTGTCAGCCCTGTCAATGCAACAACAATGTGGACCCCAGTGCCTCTGGGAATTGTGACCGGCTGACAGGCAGGTGTTT
GAAGTGTATCCACAACACAGCCGGCATCTACTGCGACCAGTGCAAAGCAGGCTACTTCGGGGACCCATTGGCTCCCAACCCAGCAGACAA
GTGTCGAGCTTGCAACTGTAACCCCATGGGCTCAGAGCCTGTAGGATGTCGAAGTGATGGCACCTGTGTTTGCAAGCCAGGATTTGGTGG
CCCCAACTGTGAGCATGGAGCATTCAGCTGTCCAGCTTGCTATAATCAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAG
AATGGAGGCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTACCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGC
CCTTCAGGACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGCAGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAA
CAGCTACCAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGAGTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATAC
TCACAGGCTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAAGCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGT
GGGGCCAAATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTAGCAGAAAGCCACGTTGAGTCAGCCAGTAACATGGAGCAACTGAC
AAGGGAAACTGAGGACTATTCCAAACAAGCCCTCTCACTGGTGCGCAAGGCCCTGCATGAAGGAGTCGGAAGCGGAAGCGGTAGCCCGGA
CGGTGCTGTGGTGCAAGGGCTTGTGGAAAAATTGGAGAAAACCAAGTCCCTGGCCCAGCAGTTGACAAGGGAGGCCACTCAAGCGGAAAT
TGAAGCAGATAGGTCTTATCAGCACAGTCTCCGCCTCCTGGATTCAGTGTCTCGGCTTCAGGGAGTCAGTGATCAGTCCTTTCAGGTGGA
AGAAGCAAAGAGGATCAAACAAAAAGCGGATTCACTCTCAAGCCTGGTAACCAGGCATATGGATGAGTTCAAGCGTACACAGAAGAATCT
GGGAAACTGGAAAGAAGAAGCACAGCAGCTCTTACAGAATGGAAAAAGTGGGAGAGAGAAATCAGATCAGCTGCTTTCCCGTGCCAATCT
TGCTAAAAGCAGAGCACAAGAAGCACTGAGTATGGGCAATGCCACTTTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGAGTTTGA
CCTGCAGGTGGACAACAGAAAAGCAGAAGCTGAAGAAGCCATGAAGAGACTCTCCTACATCAGCCAGAAGGTTTCAGATGCCAGTGACAA
GACCCAGCAAGCAGAAAGAGCCCTGGGGAGCGCTGCTGCTGATGCACAGAGGGCAAAGAATGGGGCCGGGGAGGCCCTGGAAATCTCCAG
TGAGATTGAACAGGAGATTGGGAGTCTGAACTTGGAAGCCAATGTGACAGCAGATGGAGCCTTGGCCATGGAAAAGGGACTGGCCTCTCT
GAAGAGTGAGATGAGGGAAGTGGAAGGAGAGCTGGAAAGGAAGGAGCTGGAGTTTGACACGAATATGGATGCAGTACAGATGGTGATTAC
AGAAGCCCAGAAGGTTGATACCAGAGCCAAGAACGCTGGGGTTACAATCCAAGACACACTCAACACATTAGACGGCCTCCTGCATCTGAT
GGGTATGTGAACCCACAACCCACAACCTTCCAGCTCCATGCTCCAGGGCTTTGCTCCAGAACACTCACTATACCTAGCCCCAGCAAAGGG
GAGTCTCAGCTTTCCTTAAGGATATCAGTAAATGTGCTTTGTTTCCAGGCCCAGATAACTTTCGGCAGGTTCCCTTACATTTACTGGACC
CTGTTTTACCGTTGCTAAGATGGGTCACTGAACACCTATTGCACTTGGGGGTAAAGGTCTGTGGGCCAAAGAACAGGTGTATATAAGCAA
CTTCACAGAACACGAGACAGCTTGGGAATCCTGCTAAAGAGTCTGGCCTGGACCCTGAGAAGCCAGTGGACAGTTTTAAGCAGAGGAATA
ACATCACCACTGTATATTTCAGAAAGATCACTAGGGCAGCCGAGTGGAGGAAAGCTTGAAGAGGGGGTTAGAGAGAAGGCAGGTTGAGAC
TACTTAAGATATTGTTGAAATAATTGAAGAGAGAAATGACAGGAGCCTGCTCTAAGGCAGTAGAATGGTGGCTGGGAAGATGTGAAGGAA
GATTTTCCCAGTCTGTGAAGTCAAGAATCACTTGCCGGCCGGGTGTGGTGGCTCACGCCTGTAATTCTAGCACTTTGGGAGACTGAAGCG
GGTGGATCACCCGAGGTCAGGAGTTGAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCTGGATG
TGGTGGTGGGCGCCTGTAATTCCAGCTACTCAGGAGTCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCCAAG

>In-frame_ENST00000381298_ENST00000493293_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(amino acids)=1698AA_start in transcript=313_stop in transcript=5409
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT
FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS
QIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV
KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD
QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFVCDCNGKSRQCIFDREL
HRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQR
LLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQR
NGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMPLGKTLPCGLTK
TYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYKRD
SARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARC
ELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPV
GCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQISEGA
SRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATR
LAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIEADRSYQHSLRLLD
SVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNA
TFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQEIGSLNLEAN

--------------------------------------------------------------
>In-frame_ENST00000381298_ENST00000264144_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(transcript)=7156nt_BP=2153nt
ACTGGGGTGGCGCGCTACCTCTGCGGAGAAGGATCTGACAGTGTTCCGGAGCCGGGGCGAGCAGCCAAAAGGCCCGCGGAGTCGCGCTGG
GCCGCCCCGGCGCAGCTGAACCGGGGGCCGCGCCTGCCAGGCCGACGGGTCTGGCCCAGCCTGGCGCCAAGGGGTTCGTGCGCTGTGGAG
ACGCGGAGGGTCGAGGCGGCGCGGCCTGAGTGAAACCCAATGGAAAAAGCATGACATTTAGAAGTAGAAGACTTAGCTTCAAATCCCTAC
TCCTTCACTTACTAATTTTGTGATTTGGAAATATCCGCGCAAGATGTTGACGTTGCAGACTTGGCTAGTGCAAGCCTTGTTTATTTTCCT
CACCACTGAATCTACAGGTGAACTTCTAGATCCATGTGGTTATATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGC
AGTTTGTGTGCTAAAGGAAAAATGTATGGATTATTTTCATGTAAATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAA
GGAGCAATATACTATCATAAACAGAACAGCATCCAGTGTCACCTTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCT
TACATTCGGACAGCTTGAACAGAATGTTTATGGAATCACAATAATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGT
GAACGAGGGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGGGAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAAC
ACACAAGTTTGCTGATTGCAAAGCAAAACGTGACACCCCCACCTCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGT
CTGGGTAGAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGATCATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACA
TAATTTATCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTAAAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAA
ATATAACATTCAATATAGGACCAAAGATGCCTCAACTTGGAGCCAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGT
CCAAGACCTTAAACCTTTTACAGAATATGTGTTTAGGATTCGCTGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGA
AGCAAGTGGGATCACCTATGAAGATAGACCATCTAAAGCACCAAGTTTCTGGTATAAAATAGATCCATCCCATACTCAAGGCTACAGAAC
TGTACAACTCGTGTGGAAGACATTGCCTCCTTTTGAAGCCAATGGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACA
TTTACAAAATTACACAGTTAATGCCACAAAACTGACAGTAAATCTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGT
TGGCAAATCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGACTTTCAAGCTACTCACCCTGTAATGGATCTTAAAGCATTCCCCAAAGA
TAACATGCTTTGGGTGGAATGGACTACTCCAAGGGAATCTGTAAAGAAATATATACTTGAGTGGTGTGTGTTATCAGATAAAGCACCCTG
TATCACAGACTGGCAACAAGAAGATGGTACCGTGCATCGCACCTATTTAAGAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGT
TACTCCAGTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAGGCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCG
GACAAAAAAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAACTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTAT
ATTTTATAGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGATTCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACAC
ATTGTACATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAGGATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGTCTGTGA
TTGCAATGGGAAGTCCAGGCAGTGTATCTTTGATCGGGAACTTCACAGACAAACTGGTAATGGATTCCGCTGCCTCAACTGCAATGACAA
CACTGATGGCATTCACTGCGAGAAGTGCAAGAATGGCTTTTACCGGCACAGAGAAAGGGACCGCTGTTTGCCCTGCAATTGTAACTCCAA
AGGTTCTCTTAGTGCTCGATGTGACAACTCCGGACGGTGCAGCTGTAAACCAGGTGTGACAGGAGCCAGATGCGACCGATGTCTGCCAGG
CTTCCACATGCTCACGGATGCGGGGTGCACCCAAGACCAGAGACTGCTAGACTCCAAGTGTGACTGTGACCCAGCTGGCATCGCAGGGCC
CTGTGACGCGGGCCGCTGTGTCTGCAAGCCAGCTGTCACTGGAGAACGCTGTGATAGGTGTCGATCAGGTTACTATAATCTGGATGGGGG
GAACCCTGAGGGCTGTACCCAGTGTTTCTGCTATGGGCATTCAGCCAGCTGCCGCAGCTCTGCAGAATACAGTGTCCATAAGATCACCTC
TACCTTTCATCAAGATGTTGATGGCTGGAAGGCTGTCCAACGAAATGGGTCTCCTGCAAAGCTCCAATGGTCACAGCGCCATCAAGATGT
GTTTAGCTCAGCCCAACGACTAGACCCTGTCTATTTTGTGGCTCCTGCCAAATTTCTTGGGAATCAACAGGTGAGCTATGGTCAAAGCCT
GTCCTTTGACTACCGTGTGGACAGAGGAGGCAGACACCCATCTGCCCATGATGTGATTCTGGAAGGTGCTGGTCTACGGATCACAGCTCC
CTTGATGCCACTTGGCAAGACACTGCCTTGTGGGCTCACCAAGACTTACACATTCAGGTTAAATGAGCATCCAAGCAATAATTGGAGCCC
CCAGCTGAGTTACTTTGAGTATCGAAGGTTACTGCGGAATCTCACAGCCCTCCGCATCCGAGCTACATATGGAGAATACAGTACTGGGTA
CATTGACAATGTGACCCTGATTTCAGCCCGCCCTGTCTCTGGAGCCCCAGCACCCTGGGTTGAACAGTGTATATGTCCTGTTGGGTACAA
GGGGCAATTCTGCCAGGATTGTGCTTCTGGCTACAAGAGAGATTCAGCGAGACTGGGGCCTTTTGGCACCTGTATTCCTTGTAACTGTCA
AGGGGGAGGGGCCTGTGATCCAGACACAGGAGATTGTTATTCAGGGGATGAGAATCCTGACATTGAGTGTGCTGACTGCCCAATTGGTTT
CTACAACGATCCGCACGACCCCCGCAGCTGCAAGCCATGTCCCTGTCATAACGGGTTCAGCTGCTCAGTGATGCCGGAGACGGAGGAGGT
GGTGTGCAATAACTGCCCTCCCGGGGTCACCGGTGCCCGCTGTGAGCTCTGTGCTGATGGCTACTTTGGGGACCCCTTTGGTGAACATGG
CCCAGTGAGGCCTTGTCAGCCCTGTCAATGCAACAACAATGTGGACCCCAGTGCCTCTGGGAATTGTGACCGGCTGACAGGCAGGTGTTT
GAAGTGTATCCACAACACAGCCGGCATCTACTGCGACCAGTGCAAAGCAGGCTACTTCGGGGACCCATTGGCTCCCAACCCAGCAGACAA
GTGTCGAGCTTGCAACTGTAACCCCATGGGCTCAGAGCCTGTAGGATGTCGAAGTGATGGCACCTGTGTTTGCAAGCCAGGATTTGGTGG
CCCCAACTGTGAGCATGGAGCATTCAGCTGTCCAGCTTGCTATAATCAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAG
AATGGAGGCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTACCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGC
CCTTCAGGACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGCAGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAA
CAGCTACCAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGAGTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATAC
TCACAGGCTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAAGCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGT
GGGGCCAAATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTAGCAGAAAGCCACGTTGAGTCAGCCAGTAACATGGAGCAACTGAC
AAGGGAAACTGAGGACTATTCCAAACAAGCCCTCTCACTGGTGCGCAAGGCCCTGCATGAAGGAGTCGGAAGCGGAAGCGGTAGCCCGGA
CGGTGCTGTGGTGCAAGGGCTTGTGGAAAAATTGGAGAAAACCAAGTCCCTGGCCCAGCAGTTGACAAGGGAGGCCACTCAAGCGGAAAT
TGAAGCAGATAGGTCTTATCAGCACAGTCTCCGCCTCCTGGATTCAGTGTCTCGGCTTCAGGGAGTCAGTGATCAGTCCTTTCAGGTGGA
AGAAGCAAAGAGGATCAAACAAAAAGCGGATTCACTCTCAAGCCTGGTAACCAGGCATATGGATGAGTTCAAGCGTACACAGAAGAATCT
GGGAAACTGGAAAGAAGAAGCACAGCAGCTCTTACAGAATGGAAAAAGTGGGAGAGAGAAATCAGATCAGCTGCTTTCCCGTGCCAATCT
TGCTAAAAGCAGAGCACAAGAAGCACTGAGTATGGGCAATGCCACTTTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGAGTTTGA
CCTGCAGGTGGACAACAGAAAAGCAGAAGCTGAAGAAGCCATGAAGAGACTCTCCTACATCAGCCAGAAGGTTTCAGATGCCAGTGACAA
GACCCAGCAAGCAGAAAGAGCCCTGGGGAGCGCTGCTGCTGATGCACAGAGGGCAAAGAATGGGGCCGGGGAGGCCCTGGAAATCTCCAG
TGAGATTGAACAGGAGATTGGGAGTCTGAACTTGGAAGCCAATGTGACAGCAGATGGAGCCTTGGCCATGGAAAAGGGACTGGCCTCTCT
GAAGAGTGAGATGAGGGAAGTGGAAGGAGAGCTGGAAAGGAAGGAGCTGGAGTTTGACACGAATATGGATGCAGTACAGATGGTGATTAC
AGAAGCCCAGAAGGTTGATACCAGAGCCAAGAACGCTGGGGTTACAATCCAAGACACACTCAACACATTAGACGGCCTCCTGCATCTGAT
GGACCAGCCTCTCAGTGTAGATGAAGAGGGGCTGGTCTTACTGGAGCAGAAGCTTTCCCGAGCCAAGACCCAGATCAACAGCCAACTGCG
GCCCATGATGTCAGAGCTGGAAGAGAGGGCACGTCAGCAGAGGGGCCACCTCCATTTGCTGGAGACAAGCATAGATGGGATTCTGGCTGA
TGTGAAGAACTTGGAGAACATTAGGGACAACCTGCCCCCAGGCTGCTACAATACCCAGGCTCTTGAGCAACAGTGAAGCTGCCATAAATA
TTTCTCAACTGAGGTTCTTGGGATACAGATCTCAGGGCTCGGGAGCCATGTCATGTGAGTGGGTGGGATGGGGACATTTGAACATGTTTA
ATGGGTATGCTCAGGTCAACTGACCTGACCCCATTCCTGATCCCATGGCCAGGTGGTTGTCTTATTGCACCATACTCCTTGCTTCCTGAT
GCTGGGCAATGAGGCAGATAGCACTGGGTGTGAGAATGATCAAGGATCTGGACCCCAAAGAATAGACTGGATGGAAAGACAAACTGCACA
GGCAGATGTTTGCCTCATAATAGTCGTAAGTGGAGTCCTGGAATTTGGACAAGTGCTGTTGGGATATAGTCAACTTATTCTTTGAGTAAT
GTGACTAAAGGAAAAAACTTTGACTTTGCCCAGGCATGAAATTCTTCCTAATGTCAGAACAGAGTGCAACCCAGTCACACTGTGGCCAGT
AAAATACTATTGCCTCATATTGTCCTCTGCAAGCTTCTTGCTGATCAGAGTTCCTCCTACTTACAACCCAGGGTGTGAACATGTTCTCCA
TTTTCAAGCTGGAAGAAGTGAGCAGTGTTGGAGTGAGGACCTGTAAGGCAGGCCCATTCAGAGCTATGGTGCTTGCTGGTGCCTGCCACC
TTCAAGTTCTGGACCTGGGCATGACATCCTTTCTTTTAATGATGCCATGGCAACTTAGAGATTGCATTTTTATTAAAGCATTTCCTACCA
GCAAAGCAAATGTTGGGAAAGTATTTACTTTTTCGGTTTCAAAGTGATAGAAAAGTGTGGCTTGGGCATTGAAAGAGGTAAAATTCTCTA
GATTTATTAGTCCTAATTCAATCCTACTTTTCGAACACCAAAAATGATGCGCATCAATGTATTTTATCTTATTTTCTCAATCTCCTCTCT
CTTTCCTCCACCCATAATAAGAGAATGTTCCTACTCACACTTCAGCTGGGTCACATCCATCCCTCCATTCATCCTTCCATCCATCTTTCC
ATCCATTACCTCCATCCATCCTTCCAACATATATTTATTGAGTACCTACTGTGTGCCAGGGGCTGGTGGGACAGTGGTGACATAGTCTCT
GCCCTCATAGAGTTGATTGTCTAGTGAGGAAGACAAGCATTTTTAAAAAATAAATTTAAACTTACAAACTTTGTTTGTCACAAGTGGTGT
TTATTGCAATAACCGCTTGGTTTGCAACCTCTTTGCTCAACAGAACATATGTTGCAAGACCCTCCCATGGGGGCACTTGAGTTTTGGCAA
GGCTGACAGAGCTCTGGGTTGTGCACATTTCTTTGCATTCCAGCTGTCACTCTGTGCCTTTCTACAACTGATTGCAACAGACTGTTGAGT
TATGATAACACCAGTGGGAATTGCTGGAGGAACCAGAGGCACTTCCACCTTGGCTGGGAAGACTATGGTGCTGCCTTGCTTCTGTATTTC

>In-frame_ENST00000381298_ENST00000264144_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(amino acids)=1780AA_start in transcript=313_stop in transcript=5655
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT
FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS
QIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESV
KKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD
QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFVCDCNGKSRQCIFDREL
HRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQR
LLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQR
NGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMPLGKTLPCGLTK
TYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYKRD
SARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARC
ELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPV
GCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDILRDAQISEGA
SRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATR
LAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIEADRSYQHSLRLLD
SVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNA
TFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQEIGSLNLEAN
VTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPLSVDEEGLVLL

--------------------------------------------------------------
>In-frame_ENST00000336909_ENST00000493293_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(transcript)=5995nt_BP=1876nt
TATTACATGTGTCTGTTGCAGAAATATCCGCGCAAGATGTTGACGTTGCAGACTTGGCTAGTGCAAGCCTTGTTTATTTTCCTCACCACT
GAATCTACAGGTGAACTTCTAGATCCATGTGGTTATATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGT
GTGCTAAAGGAAAAATGTATGGATTATTTTCATGTAAATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAA
TATACTATCATAAACAGAACAGCATCCAGTGTCACCTTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTC
GGACAGCTTGAACAGAATGTTTATGGAATCACAATAATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAG
GGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGGGAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAG
TTTGCTGATTGCAAAGCAAAACGTGACACCCCCACCTCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTA
GAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGATCATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTA
TCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTAAAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAAC
ATTCAATATAGGACCAAAGATGCCTCAACTTGGAGCCAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGAC
CTTAAACCTTTTACAGAATATGTGTTTAGGATTCGCTGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGT
GGGATCACCTATGAAGATAGACCATCTAAAGCACCAAGTTTCTGGTATAAAATAGATCCATCCCATACTCAAGGCTACAGAACTGTACAA
CTCGTGTGGAAGACATTGCCTCCTTTTGAAGCCAATGGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAA
AATTACACAGTTAATGCCACAAAACTGACAGTAAATCTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAA
TCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGACTTTCAAGCTACTCACCCTGTAATGGATCTTAAAGCATTCCCCAAAGATAACATG
CTTTGGGTGGAATGGACTACTCCAAGGGAATCTGTAAAGAAATATATACTTGAGTGGTGTGTGTTATCAGATAAAGCACCCTGTATCACA
GACTGGCAACAAGAAGATGGTACCGTGCATCGCACCTATTTAAGAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCA
GTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAGGCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAA
AAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAACTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTAT
AGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGATTCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTAC
ATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAGGATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGTCTGTGATTGCAAT
GGGAAGTCCAGGCAGTGTATCTTTGATCGGGAACTTCACAGACAAACTGGTAATGGATTCCGCTGCCTCAACTGCAATGACAACACTGAT
GGCATTCACTGCGAGAAGTGCAAGAATGGCTTTTACCGGCACAGAGAAAGGGACCGCTGTTTGCCCTGCAATTGTAACTCCAAAGGTTCT
CTTAGTGCTCGATGTGACAACTCCGGACGGTGCAGCTGTAAACCAGGTGTGACAGGAGCCAGATGCGACCGATGTCTGCCAGGCTTCCAC
ATGCTCACGGATGCGGGGTGCACCCAAGACCAGAGACTGCTAGACTCCAAGTGTGACTGTGACCCAGCTGGCATCGCAGGGCCCTGTGAC
GCGGGCCGCTGTGTCTGCAAGCCAGCTGTCACTGGAGAACGCTGTGATAGGTGTCGATCAGGTTACTATAATCTGGATGGGGGGAACCCT
GAGGGCTGTACCCAGTGTTTCTGCTATGGGCATTCAGCCAGCTGCCGCAGCTCTGCAGAATACAGTGTCCATAAGATCACCTCTACCTTT
CATCAAGATGTTGATGGCTGGAAGGCTGTCCAACGAAATGGGTCTCCTGCAAAGCTCCAATGGTCACAGCGCCATCAAGATGTGTTTAGC
TCAGCCCAACGACTAGACCCTGTCTATTTTGTGGCTCCTGCCAAATTTCTTGGGAATCAACAGGTGAGCTATGGTCAAAGCCTGTCCTTT
GACTACCGTGTGGACAGAGGAGGCAGACACCCATCTGCCCATGATGTGATTCTGGAAGGTGCTGGTCTACGGATCACAGCTCCCTTGATG
CCACTTGGCAAGACACTGCCTTGTGGGCTCACCAAGACTTACACATTCAGGTTAAATGAGCATCCAAGCAATAATTGGAGCCCCCAGCTG
AGTTACTTTGAGTATCGAAGGTTACTGCGGAATCTCACAGCCCTCCGCATCCGAGCTACATATGGAGAATACAGTACTGGGTACATTGAC
AATGTGACCCTGATTTCAGCCCGCCCTGTCTCTGGAGCCCCAGCACCCTGGGTTGAACAGTGTATATGTCCTGTTGGGTACAAGGGGCAA
TTCTGCCAGGATTGTGCTTCTGGCTACAAGAGAGATTCAGCGAGACTGGGGCCTTTTGGCACCTGTATTCCTTGTAACTGTCAAGGGGGA
GGGGCCTGTGATCCAGACACAGGAGATTGTTATTCAGGGGATGAGAATCCTGACATTGAGTGTGCTGACTGCCCAATTGGTTTCTACAAC
GATCCGCACGACCCCCGCAGCTGCAAGCCATGTCCCTGTCATAACGGGTTCAGCTGCTCAGTGATGCCGGAGACGGAGGAGGTGGTGTGC
AATAACTGCCCTCCCGGGGTCACCGGTGCCCGCTGTGAGCTCTGTGCTGATGGCTACTTTGGGGACCCCTTTGGTGAACATGGCCCAGTG
AGGCCTTGTCAGCCCTGTCAATGCAACAACAATGTGGACCCCAGTGCCTCTGGGAATTGTGACCGGCTGACAGGCAGGTGTTTGAAGTGT
ATCCACAACACAGCCGGCATCTACTGCGACCAGTGCAAAGCAGGCTACTTCGGGGACCCATTGGCTCCCAACCCAGCAGACAAGTGTCGA
GCTTGCAACTGTAACCCCATGGGCTCAGAGCCTGTAGGATGTCGAAGTGATGGCACCTGTGTTTGCAAGCCAGGATTTGGTGGCCCCAAC
TGTGAGCATGGAGCATTCAGCTGTCCAGCTTGCTATAATCAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAGAATGGAG
GCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTACCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGCCCTTCAG
GACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGCAGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAACAGCTAC
CAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGAGTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATACTCACAGG
CTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAAGCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGTGGGGCCA
AATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTAGCAGAAAGCCACGTTGAGTCAGCCAGTAACATGGAGCAACTGACAAGGGAA
ACTGAGGACTATTCCAAACAAGCCCTCTCACTGGTGCGCAAGGCCCTGCATGAAGGAGTCGGAAGCGGAAGCGGTAGCCCGGACGGTGCT
GTGGTGCAAGGGCTTGTGGAAAAATTGGAGAAAACCAAGTCCCTGGCCCAGCAGTTGACAAGGGAGGCCACTCAAGCGGAAATTGAAGCA
GATAGGTCTTATCAGCACAGTCTCCGCCTCCTGGATTCAGTGTCTCGGCTTCAGGGAGTCAGTGATCAGTCCTTTCAGGTGGAAGAAGCA
AAGAGGATCAAACAAAAAGCGGATTCACTCTCAAGCCTGGTAACCAGGCATATGGATGAGTTCAAGCGTACACAGAAGAATCTGGGAAAC
TGGAAAGAAGAAGCACAGCAGCTCTTACAGAATGGAAAAAGTGGGAGAGAGAAATCAGATCAGCTGCTTTCCCGTGCCAATCTTGCTAAA
AGCAGAGCACAAGAAGCACTGAGTATGGGCAATGCCACTTTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGAGTTTGACCTGCAG
GTGGACAACAGAAAAGCAGAAGCTGAAGAAGCCATGAAGAGACTCTCCTACATCAGCCAGAAGGTTTCAGATGCCAGTGACAAGACCCAG
CAAGCAGAAAGAGCCCTGGGGAGCGCTGCTGCTGATGCACAGAGGGCAAAGAATGGGGCCGGGGAGGCCCTGGAAATCTCCAGTGAGATT
GAACAGGAGATTGGGAGTCTGAACTTGGAAGCCAATGTGACAGCAGATGGAGCCTTGGCCATGGAAAAGGGACTGGCCTCTCTGAAGAGT
GAGATGAGGGAAGTGGAAGGAGAGCTGGAAAGGAAGGAGCTGGAGTTTGACACGAATATGGATGCAGTACAGATGGTGATTACAGAAGCC
CAGAAGGTTGATACCAGAGCCAAGAACGCTGGGGTTACAATCCAAGACACACTCAACACATTAGACGGCCTCCTGCATCTGATGGGTATG
TGAACCCACAACCCACAACCTTCCAGCTCCATGCTCCAGGGCTTTGCTCCAGAACACTCACTATACCTAGCCCCAGCAAAGGGGAGTCTC
AGCTTTCCTTAAGGATATCAGTAAATGTGCTTTGTTTCCAGGCCCAGATAACTTTCGGCAGGTTCCCTTACATTTACTGGACCCTGTTTT
ACCGTTGCTAAGATGGGTCACTGAACACCTATTGCACTTGGGGGTAAAGGTCTGTGGGCCAAAGAACAGGTGTATATAAGCAACTTCACA
GAACACGAGACAGCTTGGGAATCCTGCTAAAGAGTCTGGCCTGGACCCTGAGAAGCCAGTGGACAGTTTTAAGCAGAGGAATAACATCAC
CACTGTATATTTCAGAAAGATCACTAGGGCAGCCGAGTGGAGGAAAGCTTGAAGAGGGGGTTAGAGAGAAGGCAGGTTGAGACTACTTAA
GATATTGTTGAAATAATTGAAGAGAGAAATGACAGGAGCCTGCTCTAAGGCAGTAGAATGGTGGCTGGGAAGATGTGAAGGAAGATTTTC
CCAGTCTGTGAAGTCAAGAATCACTTGCCGGCCGGGTGTGGTGGCTCACGCCTGTAATTCTAGCACTTTGGGAGACTGAAGCGGGTGGAT
CACCCGAGGTCAGGAGTTGAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCTGGATGTGGTGGT
GGGCGCCTGTAATTCCAGCTACTCAGGAGTCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCCAAGATTGCAC

>In-frame_ENST00000336909_ENST00000493293_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(amino acids)=1708AA_start in transcript=6_stop in transcript=5132
MCLLQKYPRKMLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYT
IINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFA
DCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQ
YRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLV
WKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLW
VEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKV
GKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFVCDCNGK
SRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHML
TDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQ
DVDGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMPL
GKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFC
QDCASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNN
CPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRAC
NCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDI
LRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNG
FKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIEADR
SYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSR
AQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQ

--------------------------------------------------------------
>In-frame_ENST00000336909_ENST00000264144_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(transcript)=6879nt_BP=1876nt
TATTACATGTGTCTGTTGCAGAAATATCCGCGCAAGATGTTGACGTTGCAGACTTGGCTAGTGCAAGCCTTGTTTATTTTCCTCACCACT
GAATCTACAGGTGAACTTCTAGATCCATGTGGTTATATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGT
GTGCTAAAGGAAAAATGTATGGATTATTTTCATGTAAATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAA
TATACTATCATAAACAGAACAGCATCCAGTGTCACCTTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTC
GGACAGCTTGAACAGAATGTTTATGGAATCACAATAATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAG
GGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGGGAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAG
TTTGCTGATTGCAAAGCAAAACGTGACACCCCCACCTCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTA
GAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGATCATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTA
TCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTAAAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAAC
ATTCAATATAGGACCAAAGATGCCTCAACTTGGAGCCAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGAC
CTTAAACCTTTTACAGAATATGTGTTTAGGATTCGCTGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGT
GGGATCACCTATGAAGATAGACCATCTAAAGCACCAAGTTTCTGGTATAAAATAGATCCATCCCATACTCAAGGCTACAGAACTGTACAA
CTCGTGTGGAAGACATTGCCTCCTTTTGAAGCCAATGGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAA
AATTACACAGTTAATGCCACAAAACTGACAGTAAATCTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAA
TCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGACTTTCAAGCTACTCACCCTGTAATGGATCTTAAAGCATTCCCCAAAGATAACATG
CTTTGGGTGGAATGGACTACTCCAAGGGAATCTGTAAAGAAATATATACTTGAGTGGTGTGTGTTATCAGATAAAGCACCCTGTATCACA
GACTGGCAACAAGAAGATGGTACCGTGCATCGCACCTATTTAAGAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCA
GTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAGGCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAA
AAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAACTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTAT
AGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGATTCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTAC
ATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAGGATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGTCTGTGATTGCAAT
GGGAAGTCCAGGCAGTGTATCTTTGATCGGGAACTTCACAGACAAACTGGTAATGGATTCCGCTGCCTCAACTGCAATGACAACACTGAT
GGCATTCACTGCGAGAAGTGCAAGAATGGCTTTTACCGGCACAGAGAAAGGGACCGCTGTTTGCCCTGCAATTGTAACTCCAAAGGTTCT
CTTAGTGCTCGATGTGACAACTCCGGACGGTGCAGCTGTAAACCAGGTGTGACAGGAGCCAGATGCGACCGATGTCTGCCAGGCTTCCAC
ATGCTCACGGATGCGGGGTGCACCCAAGACCAGAGACTGCTAGACTCCAAGTGTGACTGTGACCCAGCTGGCATCGCAGGGCCCTGTGAC
GCGGGCCGCTGTGTCTGCAAGCCAGCTGTCACTGGAGAACGCTGTGATAGGTGTCGATCAGGTTACTATAATCTGGATGGGGGGAACCCT
GAGGGCTGTACCCAGTGTTTCTGCTATGGGCATTCAGCCAGCTGCCGCAGCTCTGCAGAATACAGTGTCCATAAGATCACCTCTACCTTT
CATCAAGATGTTGATGGCTGGAAGGCTGTCCAACGAAATGGGTCTCCTGCAAAGCTCCAATGGTCACAGCGCCATCAAGATGTGTTTAGC
TCAGCCCAACGACTAGACCCTGTCTATTTTGTGGCTCCTGCCAAATTTCTTGGGAATCAACAGGTGAGCTATGGTCAAAGCCTGTCCTTT
GACTACCGTGTGGACAGAGGAGGCAGACACCCATCTGCCCATGATGTGATTCTGGAAGGTGCTGGTCTACGGATCACAGCTCCCTTGATG
CCACTTGGCAAGACACTGCCTTGTGGGCTCACCAAGACTTACACATTCAGGTTAAATGAGCATCCAAGCAATAATTGGAGCCCCCAGCTG
AGTTACTTTGAGTATCGAAGGTTACTGCGGAATCTCACAGCCCTCCGCATCCGAGCTACATATGGAGAATACAGTACTGGGTACATTGAC
AATGTGACCCTGATTTCAGCCCGCCCTGTCTCTGGAGCCCCAGCACCCTGGGTTGAACAGTGTATATGTCCTGTTGGGTACAAGGGGCAA
TTCTGCCAGGATTGTGCTTCTGGCTACAAGAGAGATTCAGCGAGACTGGGGCCTTTTGGCACCTGTATTCCTTGTAACTGTCAAGGGGGA
GGGGCCTGTGATCCAGACACAGGAGATTGTTATTCAGGGGATGAGAATCCTGACATTGAGTGTGCTGACTGCCCAATTGGTTTCTACAAC
GATCCGCACGACCCCCGCAGCTGCAAGCCATGTCCCTGTCATAACGGGTTCAGCTGCTCAGTGATGCCGGAGACGGAGGAGGTGGTGTGC
AATAACTGCCCTCCCGGGGTCACCGGTGCCCGCTGTGAGCTCTGTGCTGATGGCTACTTTGGGGACCCCTTTGGTGAACATGGCCCAGTG
AGGCCTTGTCAGCCCTGTCAATGCAACAACAATGTGGACCCCAGTGCCTCTGGGAATTGTGACCGGCTGACAGGCAGGTGTTTGAAGTGT
ATCCACAACACAGCCGGCATCTACTGCGACCAGTGCAAAGCAGGCTACTTCGGGGACCCATTGGCTCCCAACCCAGCAGACAAGTGTCGA
GCTTGCAACTGTAACCCCATGGGCTCAGAGCCTGTAGGATGTCGAAGTGATGGCACCTGTGTTTGCAAGCCAGGATTTGGTGGCCCCAAC
TGTGAGCATGGAGCATTCAGCTGTCCAGCTTGCTATAATCAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAGAATGGAG
GCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTACCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGCCCTTCAG
GACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGCAGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAACAGCTAC
CAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGAGTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATACTCACAGG
CTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAAGCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGTGGGGCCA
AATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTAGCAGAAAGCCACGTTGAGTCAGCCAGTAACATGGAGCAACTGACAAGGGAA
ACTGAGGACTATTCCAAACAAGCCCTCTCACTGGTGCGCAAGGCCCTGCATGAAGGAGTCGGAAGCGGAAGCGGTAGCCCGGACGGTGCT
GTGGTGCAAGGGCTTGTGGAAAAATTGGAGAAAACCAAGTCCCTGGCCCAGCAGTTGACAAGGGAGGCCACTCAAGCGGAAATTGAAGCA
GATAGGTCTTATCAGCACAGTCTCCGCCTCCTGGATTCAGTGTCTCGGCTTCAGGGAGTCAGTGATCAGTCCTTTCAGGTGGAAGAAGCA
AAGAGGATCAAACAAAAAGCGGATTCACTCTCAAGCCTGGTAACCAGGCATATGGATGAGTTCAAGCGTACACAGAAGAATCTGGGAAAC
TGGAAAGAAGAAGCACAGCAGCTCTTACAGAATGGAAAAAGTGGGAGAGAGAAATCAGATCAGCTGCTTTCCCGTGCCAATCTTGCTAAA
AGCAGAGCACAAGAAGCACTGAGTATGGGCAATGCCACTTTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGAGTTTGACCTGCAG
GTGGACAACAGAAAAGCAGAAGCTGAAGAAGCCATGAAGAGACTCTCCTACATCAGCCAGAAGGTTTCAGATGCCAGTGACAAGACCCAG
CAAGCAGAAAGAGCCCTGGGGAGCGCTGCTGCTGATGCACAGAGGGCAAAGAATGGGGCCGGGGAGGCCCTGGAAATCTCCAGTGAGATT
GAACAGGAGATTGGGAGTCTGAACTTGGAAGCCAATGTGACAGCAGATGGAGCCTTGGCCATGGAAAAGGGACTGGCCTCTCTGAAGAGT
GAGATGAGGGAAGTGGAAGGAGAGCTGGAAAGGAAGGAGCTGGAGTTTGACACGAATATGGATGCAGTACAGATGGTGATTACAGAAGCC
CAGAAGGTTGATACCAGAGCCAAGAACGCTGGGGTTACAATCCAAGACACACTCAACACATTAGACGGCCTCCTGCATCTGATGGACCAG
CCTCTCAGTGTAGATGAAGAGGGGCTGGTCTTACTGGAGCAGAAGCTTTCCCGAGCCAAGACCCAGATCAACAGCCAACTGCGGCCCATG
ATGTCAGAGCTGGAAGAGAGGGCACGTCAGCAGAGGGGCCACCTCCATTTGCTGGAGACAAGCATAGATGGGATTCTGGCTGATGTGAAG
AACTTGGAGAACATTAGGGACAACCTGCCCCCAGGCTGCTACAATACCCAGGCTCTTGAGCAACAGTGAAGCTGCCATAAATATTTCTCA
ACTGAGGTTCTTGGGATACAGATCTCAGGGCTCGGGAGCCATGTCATGTGAGTGGGTGGGATGGGGACATTTGAACATGTTTAATGGGTA
TGCTCAGGTCAACTGACCTGACCCCATTCCTGATCCCATGGCCAGGTGGTTGTCTTATTGCACCATACTCCTTGCTTCCTGATGCTGGGC
AATGAGGCAGATAGCACTGGGTGTGAGAATGATCAAGGATCTGGACCCCAAAGAATAGACTGGATGGAAAGACAAACTGCACAGGCAGAT
GTTTGCCTCATAATAGTCGTAAGTGGAGTCCTGGAATTTGGACAAGTGCTGTTGGGATATAGTCAACTTATTCTTTGAGTAATGTGACTA
AAGGAAAAAACTTTGACTTTGCCCAGGCATGAAATTCTTCCTAATGTCAGAACAGAGTGCAACCCAGTCACACTGTGGCCAGTAAAATAC
TATTGCCTCATATTGTCCTCTGCAAGCTTCTTGCTGATCAGAGTTCCTCCTACTTACAACCCAGGGTGTGAACATGTTCTCCATTTTCAA
GCTGGAAGAAGTGAGCAGTGTTGGAGTGAGGACCTGTAAGGCAGGCCCATTCAGAGCTATGGTGCTTGCTGGTGCCTGCCACCTTCAAGT
TCTGGACCTGGGCATGACATCCTTTCTTTTAATGATGCCATGGCAACTTAGAGATTGCATTTTTATTAAAGCATTTCCTACCAGCAAAGC
AAATGTTGGGAAAGTATTTACTTTTTCGGTTTCAAAGTGATAGAAAAGTGTGGCTTGGGCATTGAAAGAGGTAAAATTCTCTAGATTTAT
TAGTCCTAATTCAATCCTACTTTTCGAACACCAAAAATGATGCGCATCAATGTATTTTATCTTATTTTCTCAATCTCCTCTCTCTTTCCT
CCACCCATAATAAGAGAATGTTCCTACTCACACTTCAGCTGGGTCACATCCATCCCTCCATTCATCCTTCCATCCATCTTTCCATCCATT
ACCTCCATCCATCCTTCCAACATATATTTATTGAGTACCTACTGTGTGCCAGGGGCTGGTGGGACAGTGGTGACATAGTCTCTGCCCTCA
TAGAGTTGATTGTCTAGTGAGGAAGACAAGCATTTTTAAAAAATAAATTTAAACTTACAAACTTTGTTTGTCACAAGTGGTGTTTATTGC
AATAACCGCTTGGTTTGCAACCTCTTTGCTCAACAGAACATATGTTGCAAGACCCTCCCATGGGGGCACTTGAGTTTTGGCAAGGCTGAC
AGAGCTCTGGGTTGTGCACATTTCTTTGCATTCCAGCTGTCACTCTGTGCCTTTCTACAACTGATTGCAACAGACTGTTGAGTTATGATA
ACACCAGTGGGAATTGCTGGAGGAACCAGAGGCACTTCCACCTTGGCTGGGAAGACTATGGTGCTGCCTTGCTTCTGTATTTCCTTGGAT

>In-frame_ENST00000336909_ENST00000264144_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(amino acids)=1790AA_start in transcript=6_stop in transcript=5378
MCLLQKYPRKMLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYT
IINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFA
DCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQ
YRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLV
WKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLW
VEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKV
GKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFVCDCNGK
SRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHML
TDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQ
DVDGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHDVILEGAGLRITAPLMPL
GKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFC
QDCASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPCHNGFSCSVMPETEEVVCNN
CPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRAC
NCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDTELEGRMQQAEQALQDI
LRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNG
FKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLAQQLTREATQAEIEADR
SYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSR
AQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRAKNGAGEALEISSEIEQ
EIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPL

--------------------------------------------------------------
>In-frame_ENST00000381294_ENST00000493293_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(transcript)=5776nt_BP=1657nt
ATGTTGACGTTGCAGACTTGGCTAGTGCAAGCCTTGTTTATTTTCCTCACCACTGAATCTACAGGTGAACTTCTAGATCCATGTGGTTAT
ATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGTGTGCTAAAGGAAAAATGTATGGATTATTTTCATGTA
AATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAATATACTATCATAAACAGAACAGCATCCAGTGTCACC
TTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTCGGACAGCTTGAACAGAATGTTTATGGAATCACAATA
ATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAGGGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGG
GAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAGTTTGCTGATTGCAAAGCAAAACGTGACACCCCCACC
TCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTAGAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGAT
CATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTATCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTA
AAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAACATTCAATATAGGACCAAAGATGCCTCAACTTGGAGC
CAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGACCTTAAACCTTTTACAGAATATGTGTTTAGGATTCGC
TGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGTGGGATCACCTATGAAGATAGACCATCTAAAGCACCA
AGTTTCTGGTATAAAATAGATCCATCCCATACTCAAGGCTACAGAACTGTACAACTCGTGTGGAAGACATTGCCTCCTTTTGAAGCCAAT
GGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAAAATTACACAGTTAATGCCACAAAACTGACAGTAAAT
CTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAATCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGAC
TTTCAAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCAGTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAG
GCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAAAAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAA
CTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTATAGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGAT
TCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTACATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAG
GATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGTCTGTGATTGCAATGGGAAGTCCAGGCAGTGTATCTTTGATCGGGAACTTCAC
AGACAAACTGGTAATGGATTCCGCTGCCTCAACTGCAATGACAACACTGATGGCATTCACTGCGAGAAGTGCAAGAATGGCTTTTACCGG
CACAGAGAAAGGGACCGCTGTTTGCCCTGCAATTGTAACTCCAAAGGTTCTCTTAGTGCTCGATGTGACAACTCCGGACGGTGCAGCTGT
AAACCAGGTGTGACAGGAGCCAGATGCGACCGATGTCTGCCAGGCTTCCACATGCTCACGGATGCGGGGTGCACCCAAGACCAGAGACTG
CTAGACTCCAAGTGTGACTGTGACCCAGCTGGCATCGCAGGGCCCTGTGACGCGGGCCGCTGTGTCTGCAAGCCAGCTGTCACTGGAGAA
CGCTGTGATAGGTGTCGATCAGGTTACTATAATCTGGATGGGGGGAACCCTGAGGGCTGTACCCAGTGTTTCTGCTATGGGCATTCAGCC
AGCTGCCGCAGCTCTGCAGAATACAGTGTCCATAAGATCACCTCTACCTTTCATCAAGATGTTGATGGCTGGAAGGCTGTCCAACGAAAT
GGGTCTCCTGCAAAGCTCCAATGGTCACAGCGCCATCAAGATGTGTTTAGCTCAGCCCAACGACTAGACCCTGTCTATTTTGTGGCTCCT
GCCAAATTTCTTGGGAATCAACAGGTGAGCTATGGTCAAAGCCTGTCCTTTGACTACCGTGTGGACAGAGGAGGCAGACACCCATCTGCC
CATGATGTGATTCTGGAAGGTGCTGGTCTACGGATCACAGCTCCCTTGATGCCACTTGGCAAGACACTGCCTTGTGGGCTCACCAAGACT
TACACATTCAGGTTAAATGAGCATCCAAGCAATAATTGGAGCCCCCAGCTGAGTTACTTTGAGTATCGAAGGTTACTGCGGAATCTCACA
GCCCTCCGCATCCGAGCTACATATGGAGAATACAGTACTGGGTACATTGACAATGTGACCCTGATTTCAGCCCGCCCTGTCTCTGGAGCC
CCAGCACCCTGGGTTGAACAGTGTATATGTCCTGTTGGGTACAAGGGGCAATTCTGCCAGGATTGTGCTTCTGGCTACAAGAGAGATTCA
GCGAGACTGGGGCCTTTTGGCACCTGTATTCCTTGTAACTGTCAAGGGGGAGGGGCCTGTGATCCAGACACAGGAGATTGTTATTCAGGG
GATGAGAATCCTGACATTGAGTGTGCTGACTGCCCAATTGGTTTCTACAACGATCCGCACGACCCCCGCAGCTGCAAGCCATGTCCCTGT
CATAACGGGTTCAGCTGCTCAGTGATGCCGGAGACGGAGGAGGTGGTGTGCAATAACTGCCCTCCCGGGGTCACCGGTGCCCGCTGTGAG
CTCTGTGCTGATGGCTACTTTGGGGACCCCTTTGGTGAACATGGCCCAGTGAGGCCTTGTCAGCCCTGTCAATGCAACAACAATGTGGAC
CCCAGTGCCTCTGGGAATTGTGACCGGCTGACAGGCAGGTGTTTGAAGTGTATCCACAACACAGCCGGCATCTACTGCGACCAGTGCAAA
GCAGGCTACTTCGGGGACCCATTGGCTCCCAACCCAGCAGACAAGTGTCGAGCTTGCAACTGTAACCCCATGGGCTCAGAGCCTGTAGGA
TGTCGAAGTGATGGCACCTGTGTTTGCAAGCCAGGATTTGGTGGCCCCAACTGTGAGCATGGAGCATTCAGCTGTCCAGCTTGCTATAAT
CAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAGAATGGAGGCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTA
CCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGCCCTTCAGGACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGC
AGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAACAGCTACCAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGA
GTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATACTCACAGGCTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAA
GCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGTGGGGCCAAATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTA
GCAGAAAGCCACGTTGAGTCAGCCAGTAACATGGAGCAACTGACAAGGGAAACTGAGGACTATTCCAAACAAGCCCTCTCACTGGTGCGC
AAGGCCCTGCATGAAGGAGTCGGAAGCGGAAGCGGTAGCCCGGACGGTGCTGTGGTGCAAGGGCTTGTGGAAAAATTGGAGAAAACCAAG
TCCCTGGCCCAGCAGTTGACAAGGGAGGCCACTCAAGCGGAAATTGAAGCAGATAGGTCTTATCAGCACAGTCTCCGCCTCCTGGATTCA
GTGTCTCGGCTTCAGGGAGTCAGTGATCAGTCCTTTCAGGTGGAAGAAGCAAAGAGGATCAAACAAAAAGCGGATTCACTCTCAAGCCTG
GTAACCAGGCATATGGATGAGTTCAAGCGTACACAGAAGAATCTGGGAAACTGGAAAGAAGAAGCACAGCAGCTCTTACAGAATGGAAAA
AGTGGGAGAGAGAAATCAGATCAGCTGCTTTCCCGTGCCAATCTTGCTAAAAGCAGAGCACAAGAAGCACTGAGTATGGGCAATGCCACT
TTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGAGTTTGACCTGCAGGTGGACAACAGAAAAGCAGAAGCTGAAGAAGCCATGAAG
AGACTCTCCTACATCAGCCAGAAGGTTTCAGATGCCAGTGACAAGACCCAGCAAGCAGAAAGAGCCCTGGGGAGCGCTGCTGCTGATGCA
CAGAGGGCAAAGAATGGGGCCGGGGAGGCCCTGGAAATCTCCAGTGAGATTGAACAGGAGATTGGGAGTCTGAACTTGGAAGCCAATGTG
ACAGCAGATGGAGCCTTGGCCATGGAAAAGGGACTGGCCTCTCTGAAGAGTGAGATGAGGGAAGTGGAAGGAGAGCTGGAAAGGAAGGAG
CTGGAGTTTGACACGAATATGGATGCAGTACAGATGGTGATTACAGAAGCCCAGAAGGTTGATACCAGAGCCAAGAACGCTGGGGTTACA
ATCCAAGACACACTCAACACATTAGACGGCCTCCTGCATCTGATGGGTATGTGAACCCACAACCCACAACCTTCCAGCTCCATGCTCCAG
GGCTTTGCTCCAGAACACTCACTATACCTAGCCCCAGCAAAGGGGAGTCTCAGCTTTCCTTAAGGATATCAGTAAATGTGCTTTGTTTCC
AGGCCCAGATAACTTTCGGCAGGTTCCCTTACATTTACTGGACCCTGTTTTACCGTTGCTAAGATGGGTCACTGAACACCTATTGCACTT
GGGGGTAAAGGTCTGTGGGCCAAAGAACAGGTGTATATAAGCAACTTCACAGAACACGAGACAGCTTGGGAATCCTGCTAAAGAGTCTGG
CCTGGACCCTGAGAAGCCAGTGGACAGTTTTAAGCAGAGGAATAACATCACCACTGTATATTTCAGAAAGATCACTAGGGCAGCCGAGTG
GAGGAAAGCTTGAAGAGGGGGTTAGAGAGAAGGCAGGTTGAGACTACTTAAGATATTGTTGAAATAATTGAAGAGAGAAATGACAGGAGC
CTGCTCTAAGGCAGTAGAATGGTGGCTGGGAAGATGTGAAGGAAGATTTTCCCAGTCTGTGAAGTCAAGAATCACTTGCCGGCCGGGTGT
GGTGGCTCACGCCTGTAATTCTAGCACTTTGGGAGACTGAAGCGGGTGGATCACCCGAGGTCAGGAGTTGAAGACCAGCCTGGCCAACAT
GGTGAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCTGGATGTGGTGGTGGGCGCCTGTAATTCCAGCTACTCAGGAGTCTGAGGCAG
GAGAATCGCTTGAACCCAGGAGGCGGAGGTTACAGTGAGCCAAGATTGCACCACTGCTCTCCAGCCTGGGGAACAGAGCAAGACTGTCTC

>In-frame_ENST00000381294_ENST00000493293_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(amino acids)=1637AA_start in transcript=0_stop in transcript=4913
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT
FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS
QIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQGNLAESKCYLITVTPVYADGPGSPESIK
AYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGK
DGPEFTFTTPKFVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSC
KPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSA
SCRSSAEYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSA
HDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGA
PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPC
HNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCK
AGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVV
PDTELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESE
ASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTK
SLAQQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGK
SGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADA
QRAKNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVT

--------------------------------------------------------------
>In-frame_ENST00000381294_ENST00000264144_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(transcript)=6660nt_BP=1657nt
ATGTTGACGTTGCAGACTTGGCTAGTGCAAGCCTTGTTTATTTTCCTCACCACTGAATCTACAGGTGAACTTCTAGATCCATGTGGTTAT
ATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGTGTGCTAAAGGAAAAATGTATGGATTATTTTCATGTA
AATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAATATACTATCATAAACAGAACAGCATCCAGTGTCACC
TTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTCGGACAGCTTGAACAGAATGTTTATGGAATCACAATA
ATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAGGGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGG
GAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAGTTTGCTGATTGCAAAGCAAAACGTGACACCCCCACC
TCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTAGAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGAT
CATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTATCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTA
AAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAACATTCAATATAGGACCAAAGATGCCTCAACTTGGAGC
CAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGACCTTAAACCTTTTACAGAATATGTGTTTAGGATTCGC
TGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGTGGGATCACCTATGAAGATAGACCATCTAAAGCACCA
AGTTTCTGGTATAAAATAGATCCATCCCATACTCAAGGCTACAGAACTGTACAACTCGTGTGGAAGACATTGCCTCCTTTTGAAGCCAAT
GGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAAAATTACACAGTTAATGCCACAAAACTGACAGTAAAT
CTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAATCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGAC
TTTCAAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCAGTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAG
GCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAAAAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAA
CTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTATAGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGAT
TCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTACATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAG
GATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGTCTGTGATTGCAATGGGAAGTCCAGGCAGTGTATCTTTGATCGGGAACTTCAC
AGACAAACTGGTAATGGATTCCGCTGCCTCAACTGCAATGACAACACTGATGGCATTCACTGCGAGAAGTGCAAGAATGGCTTTTACCGG
CACAGAGAAAGGGACCGCTGTTTGCCCTGCAATTGTAACTCCAAAGGTTCTCTTAGTGCTCGATGTGACAACTCCGGACGGTGCAGCTGT
AAACCAGGTGTGACAGGAGCCAGATGCGACCGATGTCTGCCAGGCTTCCACATGCTCACGGATGCGGGGTGCACCCAAGACCAGAGACTG
CTAGACTCCAAGTGTGACTGTGACCCAGCTGGCATCGCAGGGCCCTGTGACGCGGGCCGCTGTGTCTGCAAGCCAGCTGTCACTGGAGAA
CGCTGTGATAGGTGTCGATCAGGTTACTATAATCTGGATGGGGGGAACCCTGAGGGCTGTACCCAGTGTTTCTGCTATGGGCATTCAGCC
AGCTGCCGCAGCTCTGCAGAATACAGTGTCCATAAGATCACCTCTACCTTTCATCAAGATGTTGATGGCTGGAAGGCTGTCCAACGAAAT
GGGTCTCCTGCAAAGCTCCAATGGTCACAGCGCCATCAAGATGTGTTTAGCTCAGCCCAACGACTAGACCCTGTCTATTTTGTGGCTCCT
GCCAAATTTCTTGGGAATCAACAGGTGAGCTATGGTCAAAGCCTGTCCTTTGACTACCGTGTGGACAGAGGAGGCAGACACCCATCTGCC
CATGATGTGATTCTGGAAGGTGCTGGTCTACGGATCACAGCTCCCTTGATGCCACTTGGCAAGACACTGCCTTGTGGGCTCACCAAGACT
TACACATTCAGGTTAAATGAGCATCCAAGCAATAATTGGAGCCCCCAGCTGAGTTACTTTGAGTATCGAAGGTTACTGCGGAATCTCACA
GCCCTCCGCATCCGAGCTACATATGGAGAATACAGTACTGGGTACATTGACAATGTGACCCTGATTTCAGCCCGCCCTGTCTCTGGAGCC
CCAGCACCCTGGGTTGAACAGTGTATATGTCCTGTTGGGTACAAGGGGCAATTCTGCCAGGATTGTGCTTCTGGCTACAAGAGAGATTCA
GCGAGACTGGGGCCTTTTGGCACCTGTATTCCTTGTAACTGTCAAGGGGGAGGGGCCTGTGATCCAGACACAGGAGATTGTTATTCAGGG
GATGAGAATCCTGACATTGAGTGTGCTGACTGCCCAATTGGTTTCTACAACGATCCGCACGACCCCCGCAGCTGCAAGCCATGTCCCTGT
CATAACGGGTTCAGCTGCTCAGTGATGCCGGAGACGGAGGAGGTGGTGTGCAATAACTGCCCTCCCGGGGTCACCGGTGCCCGCTGTGAG
CTCTGTGCTGATGGCTACTTTGGGGACCCCTTTGGTGAACATGGCCCAGTGAGGCCTTGTCAGCCCTGTCAATGCAACAACAATGTGGAC
CCCAGTGCCTCTGGGAATTGTGACCGGCTGACAGGCAGGTGTTTGAAGTGTATCCACAACACAGCCGGCATCTACTGCGACCAGTGCAAA
GCAGGCTACTTCGGGGACCCATTGGCTCCCAACCCAGCAGACAAGTGTCGAGCTTGCAACTGTAACCCCATGGGCTCAGAGCCTGTAGGA
TGTCGAAGTGATGGCACCTGTGTTTGCAAGCCAGGATTTGGTGGCCCCAACTGTGAGCATGGAGCATTCAGCTGTCCAGCTTGCTATAAT
CAAGTGAAGATTCAGATGGATCAGTTTATGCAGCAGCTTCAGAGAATGGAGGCCCTGATTTCAAAGGCTCAGGGTGGTGATGGAGTAGTA
CCTGATACAGAGCTGGAAGGCAGGATGCAGCAGGCTGAGCAGGCCCTTCAGGACATTCTGAGAGATGCCCAGATTTCAGAAGGTGCTAGC
AGATCCCTTGGTCTCCAGTTGGCCAAGGTGAGGAGCCAAGAGAACAGCTACCAGAGCCGCCTGGATGACCTCAAGATGACTGTGGAAAGA
GTTCGGGCTCTGGGAAGTCAGTACCAGAACCGAGTTCGGGATACTCACAGGCTCATCACTCAGATGCAGCTGAGCCTGGCAGAAAGTGAA
GCTTCCTTGGGAAACACTAACATTCCTGCCTCAGACCACTACGTGGGGCCAAATGGCTTTAAAAGTCTGGCTCAGGAGGCCACAAGATTA
GCAGAAAGCCACGTTGAGTCAGCCAGTAACATGGAGCAACTGACAAGGGAAACTGAGGACTATTCCAAACAAGCCCTCTCACTGGTGCGC
AAGGCCCTGCATGAAGGAGTCGGAAGCGGAAGCGGTAGCCCGGACGGTGCTGTGGTGCAAGGGCTTGTGGAAAAATTGGAGAAAACCAAG
TCCCTGGCCCAGCAGTTGACAAGGGAGGCCACTCAAGCGGAAATTGAAGCAGATAGGTCTTATCAGCACAGTCTCCGCCTCCTGGATTCA
GTGTCTCGGCTTCAGGGAGTCAGTGATCAGTCCTTTCAGGTGGAAGAAGCAAAGAGGATCAAACAAAAAGCGGATTCACTCTCAAGCCTG
GTAACCAGGCATATGGATGAGTTCAAGCGTACACAGAAGAATCTGGGAAACTGGAAAGAAGAAGCACAGCAGCTCTTACAGAATGGAAAA
AGTGGGAGAGAGAAATCAGATCAGCTGCTTTCCCGTGCCAATCTTGCTAAAAGCAGAGCACAAGAAGCACTGAGTATGGGCAATGCCACT
TTTTATGAAGTTGAGAGCATCCTTAAAAACCTCAGAGAGTTTGACCTGCAGGTGGACAACAGAAAAGCAGAAGCTGAAGAAGCCATGAAG
AGACTCTCCTACATCAGCCAGAAGGTTTCAGATGCCAGTGACAAGACCCAGCAAGCAGAAAGAGCCCTGGGGAGCGCTGCTGCTGATGCA
CAGAGGGCAAAGAATGGGGCCGGGGAGGCCCTGGAAATCTCCAGTGAGATTGAACAGGAGATTGGGAGTCTGAACTTGGAAGCCAATGTG
ACAGCAGATGGAGCCTTGGCCATGGAAAAGGGACTGGCCTCTCTGAAGAGTGAGATGAGGGAAGTGGAAGGAGAGCTGGAAAGGAAGGAG
CTGGAGTTTGACACGAATATGGATGCAGTACAGATGGTGATTACAGAAGCCCAGAAGGTTGATACCAGAGCCAAGAACGCTGGGGTTACA
ATCCAAGACACACTCAACACATTAGACGGCCTCCTGCATCTGATGGACCAGCCTCTCAGTGTAGATGAAGAGGGGCTGGTCTTACTGGAG
CAGAAGCTTTCCCGAGCCAAGACCCAGATCAACAGCCAACTGCGGCCCATGATGTCAGAGCTGGAAGAGAGGGCACGTCAGCAGAGGGGC
CACCTCCATTTGCTGGAGACAAGCATAGATGGGATTCTGGCTGATGTGAAGAACTTGGAGAACATTAGGGACAACCTGCCCCCAGGCTGC
TACAATACCCAGGCTCTTGAGCAACAGTGAAGCTGCCATAAATATTTCTCAACTGAGGTTCTTGGGATACAGATCTCAGGGCTCGGGAGC
CATGTCATGTGAGTGGGTGGGATGGGGACATTTGAACATGTTTAATGGGTATGCTCAGGTCAACTGACCTGACCCCATTCCTGATCCCAT
GGCCAGGTGGTTGTCTTATTGCACCATACTCCTTGCTTCCTGATGCTGGGCAATGAGGCAGATAGCACTGGGTGTGAGAATGATCAAGGA
TCTGGACCCCAAAGAATAGACTGGATGGAAAGACAAACTGCACAGGCAGATGTTTGCCTCATAATAGTCGTAAGTGGAGTCCTGGAATTT
GGACAAGTGCTGTTGGGATATAGTCAACTTATTCTTTGAGTAATGTGACTAAAGGAAAAAACTTTGACTTTGCCCAGGCATGAAATTCTT
CCTAATGTCAGAACAGAGTGCAACCCAGTCACACTGTGGCCAGTAAAATACTATTGCCTCATATTGTCCTCTGCAAGCTTCTTGCTGATC
AGAGTTCCTCCTACTTACAACCCAGGGTGTGAACATGTTCTCCATTTTCAAGCTGGAAGAAGTGAGCAGTGTTGGAGTGAGGACCTGTAA
GGCAGGCCCATTCAGAGCTATGGTGCTTGCTGGTGCCTGCCACCTTCAAGTTCTGGACCTGGGCATGACATCCTTTCTTTTAATGATGCC
ATGGCAACTTAGAGATTGCATTTTTATTAAAGCATTTCCTACCAGCAAAGCAAATGTTGGGAAAGTATTTACTTTTTCGGTTTCAAAGTG
ATAGAAAAGTGTGGCTTGGGCATTGAAAGAGGTAAAATTCTCTAGATTTATTAGTCCTAATTCAATCCTACTTTTCGAACACCAAAAATG
ATGCGCATCAATGTATTTTATCTTATTTTCTCAATCTCCTCTCTCTTTCCTCCACCCATAATAAGAGAATGTTCCTACTCACACTTCAGC
TGGGTCACATCCATCCCTCCATTCATCCTTCCATCCATCTTTCCATCCATTACCTCCATCCATCCTTCCAACATATATTTATTGAGTACC
TACTGTGTGCCAGGGGCTGGTGGGACAGTGGTGACATAGTCTCTGCCCTCATAGAGTTGATTGTCTAGTGAGGAAGACAAGCATTTTTAA
AAAATAAATTTAAACTTACAAACTTTGTTTGTCACAAGTGGTGTTTATTGCAATAACCGCTTGGTTTGCAACCTCTTTGCTCAACAGAAC
ATATGTTGCAAGACCCTCCCATGGGGGCACTTGAGTTTTGGCAAGGCTGACAGAGCTCTGGGTTGTGCACATTTCTTTGCATTCCAGCTG
TCACTCTGTGCCTTTCTACAACTGATTGCAACAGACTGTTGAGTTATGATAACACCAGTGGGAATTGCTGGAGGAACCAGAGGCACTTCC
ACCTTGGCTGGGAAGACTATGGTGCTGCCTTGCTTCTGTATTTCCTTGGATTTTCCTGAAAGTGTTTTTAAATAAAGAACAATTGTTAGA

>In-frame_ENST00000381294_ENST00000264144_TCGA-YL-A9WL-01A_IL6ST_chr5_55247292_-_LAMC2_chr1_183177016_length(amino acids)=1719AA_start in transcript=0_stop in transcript=5159
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT
FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWS
QIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQGNLAESKCYLITVTPVYADGPGSPESIK
AYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGK
DGPEFTFTTPKFVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSC
KPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSA
SCRSSAEYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSA
HDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRLLRNLTALRIRATYGEYSTGYIDNVTLISARPVSGA
PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRSCKPCPC
HNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCK
AGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVV
PDTELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRALGSQYQNRVRDTHRLITQMQLSLAESE
ASLGNTNIPASDHYVGPNGFKSLAQEATRLAESHVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTK
SLAQQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSSLVTRHMDEFKRTQKNLGNWKEEAQQLLQNGK
SGREKSDQLLSRANLAKSRAQEALSMGNATFYEVESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADA
QRAKNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEFDTNMDAVQMVITEAQKVDTRAKNAGVT
IQDTLNTLDGLLHLMDQPLSVDEEGLVLLEQKLSRAKTQINSQLRPMMSELEERARQQRGHLHLLETSIDGILADVKNLENIRDNLPPGC

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Fusion Gene PPI Analysis for IL6ST-LAMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL6ST-LAMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL6ST-LAMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIL6STC0033578Prostatic Neoplasms2CTD_human
HgeneIL6STC0376358Malignant neoplasm of prostate2CTD_human
HgeneIL6STC0003873Rheumatoid Arthritis1CTD_human
HgeneIL6STC0007097Carcinoma1CTD_human
HgeneIL6STC0009402Colorectal Carcinoma1CTD_human;UNIPROT
HgeneIL6STC0009404Colorectal Neoplasms1CTD_human
HgeneIL6STC0013595Eczema1GENOMICS_ENGLAND
HgeneIL6STC0014457Eosinophilia1GENOMICS_ENGLAND
HgeneIL6STC0020517Hypersensitivity1CTD_human
HgeneIL6STC0024667Animal Mammary Neoplasms1CTD_human
HgeneIL6STC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneIL6STC0032285Pneumonia1CTD_human
HgeneIL6STC0032300Lobar Pneumonia1CTD_human
HgeneIL6STC0035126Reperfusion Injury1CTD_human
HgeneIL6STC0151744Myocardial Ischemia1CTD_human
HgeneIL6STC0205696Anaplastic carcinoma1CTD_human
HgeneIL6STC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneIL6STC0205698Undifferentiated carcinoma1CTD_human
HgeneIL6STC0205699Carcinomatosis1CTD_human
HgeneIL6STC0236175Increased IgE level1GENOMICS_ENGLAND
HgeneIL6STC0238281Middle Cerebral Artery Syndrome1CTD_human
HgeneIL6STC0239998Recurrent infections1GENOMICS_ENGLAND
HgeneIL6STC0740376Middle Cerebral Artery Thrombosis1CTD_human
HgeneIL6STC0740391Middle Cerebral Artery Occlusion1CTD_human
HgeneIL6STC0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneIL6STC0751845Middle Cerebral Artery Embolus1CTD_human
HgeneIL6STC0751846Left Middle Cerebral Artery Infarction1CTD_human
HgeneIL6STC0751847Embolic Infarction, Middle Cerebral Artery1CTD_human
HgeneIL6STC0751848Thrombotic Infarction, Middle Cerebral Artery1CTD_human
HgeneIL6STC0751849Right Middle Cerebral Artery Infarction1CTD_human
HgeneIL6STC0887898Experimental Lung Inflammation1CTD_human
HgeneIL6STC0919267ovarian neoplasm1CTD_human
HgeneIL6STC1140680Malignant neoplasm of ovary1CTD_human
HgeneIL6STC1257925Mammary Carcinoma, Animal1CTD_human
HgeneIL6STC1527304Allergic Reaction1CTD_human
HgeneIL6STC3714636Pneumonitis1CTD_human
TgeneLAMC2C0268374Adult junctional epidermolysis bullosa (disorder)4CTD_human;GENOMICS_ENGLAND
TgeneLAMC2C0079683Herlitz Disease3CTD_human;GENOMICS_ENGLAND
TgeneLAMC2C0079301Junctional Epidermolysis Bullosa2CTD_human;GENOMICS_ENGLAND
TgeneLAMC2C0002452Amelogenesis Imperfecta1GENOMICS_ENGLAND
TgeneLAMC2C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneLAMC2C0023890Liver Cirrhosis1CTD_human
TgeneLAMC2C0235874Disease Exacerbation1CTD_human
TgeneLAMC2C0239946Fibrosis, Liver1CTD_human
TgeneLAMC2C2608084EPIDERMOLYSIS BULLOSA, JUNCTIONAL, LOCALISATA VARIANT (disorder)1CTD_human