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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:INCENP-CCS (FusionGDB2 ID:39557)

Fusion Gene Summary for INCENP-CCS

check button Fusion gene summary
Fusion gene informationFusion gene name: INCENP-CCS
Fusion gene ID: 39557
HgeneTgene
Gene symbol

INCENP

CCS

Gene ID

3619

9973

Gene nameinner centromere proteincopper chaperone for superoxide dismutase
Synonyms--
Cytomap

11q12.3

11q13.2

Type of geneprotein-codingprotein-coding
Descriptioninner centromere proteinbinds and activates aurora-B and -C in vivo and in vitrochromosomal passenger proteininner centromere protein INCENPinner centromere protein antigens 135/155kDacopper chaperone for superoxide dismutasesuperoxide dismutase copper chaperone
Modification date2020031320200329
UniProtAcc.

Q9H7U1

Ensembl transtripts involved in fusion geneENST00000394818, ENST00000278849, 
ENST00000531099, 		ENST00000533244, 
ENST00000310190, 
Fusion gene scores* DoF score3 X 4 X 3=365 X 4 X 5=100
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INCENP [Title/Abstract] AND CCS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointINCENP(61908516)-CCS(66372810), # samples:2
INCENP(61908983)-CCS(66372810), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across INCENP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-8153-01AINCENPchr11

61908516

+CCSchr11

66372810

+
ChimerDB4LUSCTCGA-77-8153INCENPchr11

61908516

+CCSchr11

66372810

+
ChimerDB4LUSCTCGA-77-8153INCENPchr11

61908983

+CCSchr11

66372810

+
ChimerDB4LUSCTCGA-77-8153-01AINCENPchr11

61908983

-CCSchr11

66372810

+


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Fusion Gene ORF analysis for INCENP-CCS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394818ENST00000533244INCENPchr11

61908516

+CCSchr11

66372810

+
In-frameENST00000394818ENST00000310190INCENPchr11

61908516

+CCSchr11

66372810

+
In-frameENST00000278849ENST00000533244INCENPchr11

61908516

+CCSchr11

66372810

+
In-frameENST00000278849ENST00000310190INCENPchr11

61908516

+CCSchr11

66372810

+
intron-3CDSENST00000531099ENST00000533244INCENPchr11

61908516

+CCSchr11

66372810

+
intron-3CDSENST00000531099ENST00000310190INCENPchr11

61908516

+CCSchr11

66372810

+
In-frameENST00000394818ENST00000533244INCENPchr11

61908983

+CCSchr11

66372810

+
In-frameENST00000394818ENST00000310190INCENPchr11

61908983

+CCSchr11

66372810

+
intron-3CDSENST00000278849ENST00000533244INCENPchr11

61908983

+CCSchr11

66372810

+
intron-3CDSENST00000278849ENST00000310190INCENPchr11

61908983

+CCSchr11

66372810

+
intron-3CDSENST00000531099ENST00000533244INCENPchr11

61908983

+CCSchr11

66372810

+
intron-3CDSENST00000531099ENST00000310190INCENPchr11

61908983

+CCSchr11

66372810

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394818INCENPchr1161908516+ENST00000533244CCSchr1166372810+22951795672130687
ENST00000394818INCENPchr1161908516+ENST00000310190CCSchr1166372810+21951795672130687
ENST00000278849INCENPchr1161908516+ENST00000533244CCSchr1166372810+22701770422105687
ENST00000278849INCENPchr1161908516+ENST00000310190CCSchr1166372810+21701770422105687
ENST00000394818INCENPchr1161908983+ENST00000533244CCSchr1166372810+23071807672142691
ENST00000394818INCENPchr1161908983+ENST00000310190CCSchr1166372810+22071807672142691

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394818ENST00000533244INCENPchr1161908516+CCSchr1166372810+0.0275589190.972441
ENST00000394818ENST00000310190INCENPchr1161908516+CCSchr1166372810+0.0355019530.96449804
ENST00000278849ENST00000533244INCENPchr1161908516+CCSchr1166372810+0.0264261250.9735738
ENST00000278849ENST00000310190INCENPchr1161908516+CCSchr1166372810+0.0343697370.9656303
ENST00000394818ENST00000533244INCENPchr1161908983+CCSchr1166372810+0.0277012750.9722987
ENST00000394818ENST00000310190INCENPchr1161908983+CCSchr1166372810+0.035586890.9644131

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Fusion Genomic Features for INCENP-CCS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
INCENPchr1161908983+CCSchr1166372809+0.0051402350.9948598
INCENPchr1161908516+CCSchr1166372809+1.08E-060.9999989
INCENPchr1161908516+CCSchr1166372809+1.08E-060.9999989
INCENPchr1161908983+CCSchr1166372809+0.0051402350.9948598
INCENPchr1161908516+CCSchr1166372809+1.08E-060.9999989
INCENPchr1161908516+CCSchr1166372809+1.08E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for INCENP-CCS


check button Go to

FGviewer for the breakpoints of chr11:61908516-chr11:66372810

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCS

Q9H7U1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINCENPchr11:61908516chr11:66372810ENST00000278849+1018167_171531.0915.0MotifPXVXL/I motif
HgeneINCENPchr11:61908516chr11:66372810ENST00000394818+1019167_171531.0919.0MotifPXVXL/I motif
HgeneINCENPchr11:61908983chr11:66372810ENST00000394818+1119167_171535.0919.0MotifPXVXL/I motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINCENPchr11:61908983chr11:66372810ENST00000278849+118167_1710915.0MotifPXVXL/I motif
HgeneINCENPchr11:61908516chr11:66372810ENST00000278849+1018531_765531.0915.0RegionSAH
HgeneINCENPchr11:61908516chr11:66372810ENST00000278849+1018826_900531.0915.0RegionIN box
HgeneINCENPchr11:61908516chr11:66372810ENST00000394818+1019531_765531.0919.0RegionSAH
HgeneINCENPchr11:61908516chr11:66372810ENST00000394818+1019826_900531.0919.0RegionIN box
HgeneINCENPchr11:61908983chr11:66372810ENST00000278849+118531_7650915.0RegionSAH
HgeneINCENPchr11:61908983chr11:66372810ENST00000278849+118826_9000915.0RegionIN box
HgeneINCENPchr11:61908983chr11:66372810ENST00000394818+1119531_765535.0919.0RegionSAH
HgeneINCENPchr11:61908983chr11:66372810ENST00000394818+1119826_900535.0919.0RegionIN box
TgeneCCSchr11:61908516chr11:66372810ENST000005332444812_75163.0275.0DomainHMA
TgeneCCSchr11:61908983chr11:66372810ENST000005332444812_75163.0275.0DomainHMA
TgeneCCSchr11:61908516chr11:66372810ENST000005332444888_234163.0275.0RegionNote=Superoxide dismutase-like
TgeneCCSchr11:61908983chr11:66372810ENST000005332444888_234163.0275.0RegionNote=Superoxide dismutase-like


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Fusion Gene Sequence for INCENP-CCS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000394818_ENST00000533244_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(transcript)=2295nt_BP=1795nt
CTTGCCGAGGATTGGCTGAGCCTTCAGTTTTGAAAATCATAGTTTTCGCCCGCGCTGCGCCGCCTGGTTGCTCCTCCCGTGCGGTGAGTC
CCGAAGGCCCGGAGCCAAGTGGGTCTGGGCAAGCGGGGCCTTACCTAGGGATACCACCGGACTTGGATCGGAGCAGCCTTCAGGGGACGT
GGCGCAGTCGAACAGAGCCACCATGGGGACGACGGCCCCAGGGCCCATTCACCTGCTGGAGCTATGTGACCAGAAGCTCATGGAGTTTCT
CTGCAACATGGATAATAAGGACTTGGTGTGGCTTGAGGAAATCCAAGAGGAGGCCGAGCGCATGTTCACCAGAGAATTCAGCAAAGAGCC
AGAGCTGATGCCCAAAACACCTTCTCAGAAGAACCGACGGAAGAAGAGACGGATTTCTTATGTTCAGGATGAAAACAGAGATCCCATCAG
GAGAAGGTTATCCCGCAGAAAGTCTCGGAGCAGCCAGCTGAGCTCCCGACGCCTCCGCAGCAAGGACAGTGTAGAGAAGCTGGCTACAGT
GGTCGGGGAGAACGGCTCCGTCCTGCGGCGTGTGACCCGTGCTGCGGCTGCAGCTGCCGCGGCTACCATGGCATTGGCTGCACCTTCTTC
ACCCACCCCTGAGTCTCCCACGATGCTGACTAAGAAGCCCGAGGATAACCACACCCAGTGCCAGCTGGTGCCTGTGGTGGAGATCGGCAT
CAGTGAGCGCCAGAATGCTGAGCAGCATGTCACCCAGCTCATGTCCACCGAGCCTCTGCCCCGCACTCTGTCCCCGACTCCAGCTTCAGC
CACAGCTCCAACCTCCCAGGGCATCCCGACATCAGATGAGGAATCAACACCTAAGAAGTCGAAGGCCAGGATACTGGAGTCCATCACAGT
GAGCTCCCTGATGGCTACACCCCAGGACCCCAAGGGTCAAGGGGTCGGGACGGGGCGGTCTGCGTCTAAGCTCAGGATTGCGCAGGTCTC
CCCTGGCCCACGGGACTCGCCAGCCTTTCCAGATTCTCCATGGCGGGAGCGGGTGCTGGCTCCCATCCTGCCGGATAACTTCTCCACGCC
CACGGGCTCTCGCACGGACTCTCAATCGGTGCGGCACAGCCCGATCGCCCCGTCTTCCCCGAGTCCCCAAGTCTTAGCCCAGAAGTACTC
TCTGGTGGCCAAACAGGAAAGTGTTGTCCGCAGGGCGAGCAGAAGGCTTGCCAAGAAGACTGCCGAAGAGCCAGCTGCCTCTGGCCGCAT
CATCTGTCACAGTTACCTGGAGAGGCTCCTGAATGTTGAGGTGCCCCAGAAAGTTGGTTCTGAGCAGAAGGAACCCCCCGAGGAGGCTGA
GCCTGTGGCGGCAGCTGAGCCAGAGGTCCCTGAGAACAATGGAAATAACTCGTGGCCCCACAATGACACGGAGATTGCCAACAGCACACC
CAACCCGAAGCCTGCAGCCAGCAGCCCGGAAACACCCTCTGCAGGGCAGCAAGAGGCCAAGACGGACCAAGCAGATGGACCCAGAGAGCC
ACCGCAGAGTGCCAGGAGGAAGCGCAGCTACAAGCAGGCCGTGAGTGAGCTGGACGAGGAGCAGCACCTGGAGGATGAGGAGCTGCAGCC
CCCCAGGAGCAAGACCCCTTCCTCACCCTGCCCAGCCAGCAAGGTGGTACGGCCCCTCCGGACCTTTCTGCACACAGTGCAGAGGAACCA
GATGCTCATGACCCCGACCTCAGCCCCACGCAGCGTCATGAAGTCCTTTATTAAGCGCAACACTCCCCTGCGCATGGACCCCAAGCACCG
CGGAGACCTGGGCAATGTCCGTGCTGATGCTGACGGCCGCGCCATCTTCAGAATGGAGGATGAGCAGCTGAAGGTGTGGGATGTGATTGG
CCGCAGCCTGATTATTGATGAGGGAGAAGATGACCTGGGCCGGGGAGGCCATCCCTTATCCAAGATCACAGGGAACTCCGGGGAGAGGTT
GGCCTGTGGCATCATTGCACGCTCCGCTGGCCTTTTCCAGAACCCCAAGCAGATCTGCTCTTGCGATGGCCTCACCATCTGGGAGGAGCG
AGGCCGGCCCATCGCTGGCAAGGGCCGAAAGGAGTCAGCGCAGCCCCCTGCCCACCTTTGAGCAGGACCTCACCTTGGCTCTGTTGCTGT
CCTCCAGGGCGAGCACTTTCCACTTCCAGAGGGGGCCAGAGGGACTTTGCCTGCCCAGTCTTTGGAGAGCTCAGTACAGGGCAGGAGCTG

>In-frame_ENST00000394818_ENST00000533244_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(amino acids)=687AA_start in transcript=67_stop in transcript=2130
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------
>In-frame_ENST00000394818_ENST00000310190_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(transcript)=2195nt_BP=1795nt
CTTGCCGAGGATTGGCTGAGCCTTCAGTTTTGAAAATCATAGTTTTCGCCCGCGCTGCGCCGCCTGGTTGCTCCTCCCGTGCGGTGAGTC
CCGAAGGCCCGGAGCCAAGTGGGTCTGGGCAAGCGGGGCCTTACCTAGGGATACCACCGGACTTGGATCGGAGCAGCCTTCAGGGGACGT
GGCGCAGTCGAACAGAGCCACCATGGGGACGACGGCCCCAGGGCCCATTCACCTGCTGGAGCTATGTGACCAGAAGCTCATGGAGTTTCT
CTGCAACATGGATAATAAGGACTTGGTGTGGCTTGAGGAAATCCAAGAGGAGGCCGAGCGCATGTTCACCAGAGAATTCAGCAAAGAGCC
AGAGCTGATGCCCAAAACACCTTCTCAGAAGAACCGACGGAAGAAGAGACGGATTTCTTATGTTCAGGATGAAAACAGAGATCCCATCAG
GAGAAGGTTATCCCGCAGAAAGTCTCGGAGCAGCCAGCTGAGCTCCCGACGCCTCCGCAGCAAGGACAGTGTAGAGAAGCTGGCTACAGT
GGTCGGGGAGAACGGCTCCGTCCTGCGGCGTGTGACCCGTGCTGCGGCTGCAGCTGCCGCGGCTACCATGGCATTGGCTGCACCTTCTTC
ACCCACCCCTGAGTCTCCCACGATGCTGACTAAGAAGCCCGAGGATAACCACACCCAGTGCCAGCTGGTGCCTGTGGTGGAGATCGGCAT
CAGTGAGCGCCAGAATGCTGAGCAGCATGTCACCCAGCTCATGTCCACCGAGCCTCTGCCCCGCACTCTGTCCCCGACTCCAGCTTCAGC
CACAGCTCCAACCTCCCAGGGCATCCCGACATCAGATGAGGAATCAACACCTAAGAAGTCGAAGGCCAGGATACTGGAGTCCATCACAGT
GAGCTCCCTGATGGCTACACCCCAGGACCCCAAGGGTCAAGGGGTCGGGACGGGGCGGTCTGCGTCTAAGCTCAGGATTGCGCAGGTCTC
CCCTGGCCCACGGGACTCGCCAGCCTTTCCAGATTCTCCATGGCGGGAGCGGGTGCTGGCTCCCATCCTGCCGGATAACTTCTCCACGCC
CACGGGCTCTCGCACGGACTCTCAATCGGTGCGGCACAGCCCGATCGCCCCGTCTTCCCCGAGTCCCCAAGTCTTAGCCCAGAAGTACTC
TCTGGTGGCCAAACAGGAAAGTGTTGTCCGCAGGGCGAGCAGAAGGCTTGCCAAGAAGACTGCCGAAGAGCCAGCTGCCTCTGGCCGCAT
CATCTGTCACAGTTACCTGGAGAGGCTCCTGAATGTTGAGGTGCCCCAGAAAGTTGGTTCTGAGCAGAAGGAACCCCCCGAGGAGGCTGA
GCCTGTGGCGGCAGCTGAGCCAGAGGTCCCTGAGAACAATGGAAATAACTCGTGGCCCCACAATGACACGGAGATTGCCAACAGCACACC
CAACCCGAAGCCTGCAGCCAGCAGCCCGGAAACACCCTCTGCAGGGCAGCAAGAGGCCAAGACGGACCAAGCAGATGGACCCAGAGAGCC
ACCGCAGAGTGCCAGGAGGAAGCGCAGCTACAAGCAGGCCGTGAGTGAGCTGGACGAGGAGCAGCACCTGGAGGATGAGGAGCTGCAGCC
CCCCAGGAGCAAGACCCCTTCCTCACCCTGCCCAGCCAGCAAGGTGGTACGGCCCCTCCGGACCTTTCTGCACACAGTGCAGAGGAACCA
GATGCTCATGACCCCGACCTCAGCCCCACGCAGCGTCATGAAGTCCTTTATTAAGCGCAACACTCCCCTGCGCATGGACCCCAAGCACCG
CGGAGACCTGGGCAATGTCCGTGCTGATGCTGACGGCCGCGCCATCTTCAGAATGGAGGATGAGCAGCTGAAGGTGTGGGATGTGATTGG
CCGCAGCCTGATTATTGATGAGGGAGAAGATGACCTGGGCCGGGGAGGCCATCCCTTATCCAAGATCACAGGGAACTCCGGGGAGAGGTT
GGCCTGTGGCATCATTGCACGCTCCGCTGGCCTTTTCCAGAACCCCAAGCAGATCTGCTCTTGCGATGGCCTCACCATCTGGGAGGAGCG
AGGCCGGCCCATCGCTGGCAAGGGCCGAAAGGAGTCAGCGCAGCCCCCTGCCCACCTTTGAGCAGGACCTCACCTTGGCTCTGTTGCTGT

>In-frame_ENST00000394818_ENST00000310190_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(amino acids)=687AA_start in transcript=67_stop in transcript=2130
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------
>In-frame_ENST00000278849_ENST00000533244_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(transcript)=2270nt_BP=1770nt
AGTTTTGAAAATCATAGTTTTCGCCCGCGCTGCGCCGCCTGGTTGCTCCTCCCGTGCGGTGAGTCCCGAAGGCCCGGAGCCAAGTGGGTC
TGGGCAAGCGGGGCCTTACCTAGGGATACCACCGGACTTGGATCGGAGCAGCCTTCAGGGGACGTGGCGCAGTCGAACAGAGCCACCATG
GGGACGACGGCCCCAGGGCCCATTCACCTGCTGGAGCTATGTGACCAGAAGCTCATGGAGTTTCTCTGCAACATGGATAATAAGGACTTG
GTGTGGCTTGAGGAAATCCAAGAGGAGGCCGAGCGCATGTTCACCAGAGAATTCAGCAAAGAGCCAGAGCTGATGCCCAAAACACCTTCT
CAGAAGAACCGACGGAAGAAGAGACGGATTTCTTATGTTCAGGATGAAAACAGAGATCCCATCAGGAGAAGGTTATCCCGCAGAAAGTCT
CGGAGCAGCCAGCTGAGCTCCCGACGCCTCCGCAGCAAGGACAGTGTAGAGAAGCTGGCTACAGTGGTCGGGGAGAACGGCTCCGTCCTG
CGGCGTGTGACCCGTGCTGCGGCTGCAGCTGCCGCGGCTACCATGGCATTGGCTGCACCTTCTTCACCCACCCCTGAGTCTCCCACGATG
CTGACTAAGAAGCCCGAGGATAACCACACCCAGTGCCAGCTGGTGCCTGTGGTGGAGATCGGCATCAGTGAGCGCCAGAATGCTGAGCAG
CATGTCACCCAGCTCATGTCCACCGAGCCTCTGCCCCGCACTCTGTCCCCGACTCCAGCTTCAGCCACAGCTCCAACCTCCCAGGGCATC
CCGACATCAGATGAGGAATCAACACCTAAGAAGTCGAAGGCCAGGATACTGGAGTCCATCACAGTGAGCTCCCTGATGGCTACACCCCAG
GACCCCAAGGGTCAAGGGGTCGGGACGGGGCGGTCTGCGTCTAAGCTCAGGATTGCGCAGGTCTCCCCTGGCCCACGGGACTCGCCAGCC
TTTCCAGATTCTCCATGGCGGGAGCGGGTGCTGGCTCCCATCCTGCCGGATAACTTCTCCACGCCCACGGGCTCTCGCACGGACTCTCAA
TCGGTGCGGCACAGCCCGATCGCCCCGTCTTCCCCGAGTCCCCAAGTCTTAGCCCAGAAGTACTCTCTGGTGGCCAAACAGGAAAGTGTT
GTCCGCAGGGCGAGCAGAAGGCTTGCCAAGAAGACTGCCGAAGAGCCAGCTGCCTCTGGCCGCATCATCTGTCACAGTTACCTGGAGAGG
CTCCTGAATGTTGAGGTGCCCCAGAAAGTTGGTTCTGAGCAGAAGGAACCCCCCGAGGAGGCTGAGCCTGTGGCGGCAGCTGAGCCAGAG
GTCCCTGAGAACAATGGAAATAACTCGTGGCCCCACAATGACACGGAGATTGCCAACAGCACACCCAACCCGAAGCCTGCAGCCAGCAGC
CCGGAAACACCCTCTGCAGGGCAGCAAGAGGCCAAGACGGACCAAGCAGATGGACCCAGAGAGCCACCGCAGAGTGCCAGGAGGAAGCGC
AGCTACAAGCAGGCCGTGAGTGAGCTGGACGAGGAGCAGCACCTGGAGGATGAGGAGCTGCAGCCCCCCAGGAGCAAGACCCCTTCCTCA
CCCTGCCCAGCCAGCAAGGTGGTACGGCCCCTCCGGACCTTTCTGCACACAGTGCAGAGGAACCAGATGCTCATGACCCCGACCTCAGCC
CCACGCAGCGTCATGAAGTCCTTTATTAAGCGCAACACTCCCCTGCGCATGGACCCCAAGCACCGCGGAGACCTGGGCAATGTCCGTGCT
GATGCTGACGGCCGCGCCATCTTCAGAATGGAGGATGAGCAGCTGAAGGTGTGGGATGTGATTGGCCGCAGCCTGATTATTGATGAGGGA
GAAGATGACCTGGGCCGGGGAGGCCATCCCTTATCCAAGATCACAGGGAACTCCGGGGAGAGGTTGGCCTGTGGCATCATTGCACGCTCC
GCTGGCCTTTTCCAGAACCCCAAGCAGATCTGCTCTTGCGATGGCCTCACCATCTGGGAGGAGCGAGGCCGGCCCATCGCTGGCAAGGGC
CGAAAGGAGTCAGCGCAGCCCCCTGCCCACCTTTGAGCAGGACCTCACCTTGGCTCTGTTGCTGTCCTCCAGGGCGAGCACTTTCCACTT
CCAGAGGGGGCCAGAGGGACTTTGCCTGCCCAGTCTTTGGAGAGCTCAGTACAGGGCAGGAGCTGCTGTGGTGTTCCCTTGGCAAATGAA

>In-frame_ENST00000278849_ENST00000533244_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(amino acids)=687AA_start in transcript=42_stop in transcript=2105
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------
>In-frame_ENST00000278849_ENST00000310190_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(transcript)=2170nt_BP=1770nt
AGTTTTGAAAATCATAGTTTTCGCCCGCGCTGCGCCGCCTGGTTGCTCCTCCCGTGCGGTGAGTCCCGAAGGCCCGGAGCCAAGTGGGTC
TGGGCAAGCGGGGCCTTACCTAGGGATACCACCGGACTTGGATCGGAGCAGCCTTCAGGGGACGTGGCGCAGTCGAACAGAGCCACCATG
GGGACGACGGCCCCAGGGCCCATTCACCTGCTGGAGCTATGTGACCAGAAGCTCATGGAGTTTCTCTGCAACATGGATAATAAGGACTTG
GTGTGGCTTGAGGAAATCCAAGAGGAGGCCGAGCGCATGTTCACCAGAGAATTCAGCAAAGAGCCAGAGCTGATGCCCAAAACACCTTCT
CAGAAGAACCGACGGAAGAAGAGACGGATTTCTTATGTTCAGGATGAAAACAGAGATCCCATCAGGAGAAGGTTATCCCGCAGAAAGTCT
CGGAGCAGCCAGCTGAGCTCCCGACGCCTCCGCAGCAAGGACAGTGTAGAGAAGCTGGCTACAGTGGTCGGGGAGAACGGCTCCGTCCTG
CGGCGTGTGACCCGTGCTGCGGCTGCAGCTGCCGCGGCTACCATGGCATTGGCTGCACCTTCTTCACCCACCCCTGAGTCTCCCACGATG
CTGACTAAGAAGCCCGAGGATAACCACACCCAGTGCCAGCTGGTGCCTGTGGTGGAGATCGGCATCAGTGAGCGCCAGAATGCTGAGCAG
CATGTCACCCAGCTCATGTCCACCGAGCCTCTGCCCCGCACTCTGTCCCCGACTCCAGCTTCAGCCACAGCTCCAACCTCCCAGGGCATC
CCGACATCAGATGAGGAATCAACACCTAAGAAGTCGAAGGCCAGGATACTGGAGTCCATCACAGTGAGCTCCCTGATGGCTACACCCCAG
GACCCCAAGGGTCAAGGGGTCGGGACGGGGCGGTCTGCGTCTAAGCTCAGGATTGCGCAGGTCTCCCCTGGCCCACGGGACTCGCCAGCC
TTTCCAGATTCTCCATGGCGGGAGCGGGTGCTGGCTCCCATCCTGCCGGATAACTTCTCCACGCCCACGGGCTCTCGCACGGACTCTCAA
TCGGTGCGGCACAGCCCGATCGCCCCGTCTTCCCCGAGTCCCCAAGTCTTAGCCCAGAAGTACTCTCTGGTGGCCAAACAGGAAAGTGTT
GTCCGCAGGGCGAGCAGAAGGCTTGCCAAGAAGACTGCCGAAGAGCCAGCTGCCTCTGGCCGCATCATCTGTCACAGTTACCTGGAGAGG
CTCCTGAATGTTGAGGTGCCCCAGAAAGTTGGTTCTGAGCAGAAGGAACCCCCCGAGGAGGCTGAGCCTGTGGCGGCAGCTGAGCCAGAG
GTCCCTGAGAACAATGGAAATAACTCGTGGCCCCACAATGACACGGAGATTGCCAACAGCACACCCAACCCGAAGCCTGCAGCCAGCAGC
CCGGAAACACCCTCTGCAGGGCAGCAAGAGGCCAAGACGGACCAAGCAGATGGACCCAGAGAGCCACCGCAGAGTGCCAGGAGGAAGCGC
AGCTACAAGCAGGCCGTGAGTGAGCTGGACGAGGAGCAGCACCTGGAGGATGAGGAGCTGCAGCCCCCCAGGAGCAAGACCCCTTCCTCA
CCCTGCCCAGCCAGCAAGGTGGTACGGCCCCTCCGGACCTTTCTGCACACAGTGCAGAGGAACCAGATGCTCATGACCCCGACCTCAGCC
CCACGCAGCGTCATGAAGTCCTTTATTAAGCGCAACACTCCCCTGCGCATGGACCCCAAGCACCGCGGAGACCTGGGCAATGTCCGTGCT
GATGCTGACGGCCGCGCCATCTTCAGAATGGAGGATGAGCAGCTGAAGGTGTGGGATGTGATTGGCCGCAGCCTGATTATTGATGAGGGA
GAAGATGACCTGGGCCGGGGAGGCCATCCCTTATCCAAGATCACAGGGAACTCCGGGGAGAGGTTGGCCTGTGGCATCATTGCACGCTCC
GCTGGCCTTTTCCAGAACCCCAAGCAGATCTGCTCTTGCGATGGCCTCACCATCTGGGAGGAGCGAGGCCGGCCCATCGCTGGCAAGGGC
CGAAAGGAGTCAGCGCAGCCCCCTGCCCACCTTTGAGCAGGACCTCACCTTGGCTCTGTTGCTGTCCTCCAGGGCGAGCACTTTCCACTT

>In-frame_ENST00000278849_ENST00000310190_TCGA-77-8153-01A_INCENP_chr11_61908516_+_CCS_chr11_66372810_length(amino acids)=687AA_start in transcript=42_stop in transcript=2105
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKI

--------------------------------------------------------------
>In-frame_ENST00000394818_ENST00000533244_TCGA-77-8153_INCENP_chr11_61908983_+_CCS_chr11_66372810_length(transcript)=2307nt_BP=1807nt
CTTGCCGAGGATTGGCTGAGCCTTCAGTTTTGAAAATCATAGTTTTCGCCCGCGCTGCGCCGCCTGGTTGCTCCTCCCGTGCGGTGAGTC
CCGAAGGCCCGGAGCCAAGTGGGTCTGGGCAAGCGGGGCCTTACCTAGGGATACCACCGGACTTGGATCGGAGCAGCCTTCAGGGGACGT
GGCGCAGTCGAACAGAGCCACCATGGGGACGACGGCCCCAGGGCCCATTCACCTGCTGGAGCTATGTGACCAGAAGCTCATGGAGTTTCT
CTGCAACATGGATAATAAGGACTTGGTGTGGCTTGAGGAAATCCAAGAGGAGGCCGAGCGCATGTTCACCAGAGAATTCAGCAAAGAGCC
AGAGCTGATGCCCAAAACACCTTCTCAGAAGAACCGACGGAAGAAGAGACGGATTTCTTATGTTCAGGATGAAAACAGAGATCCCATCAG
GAGAAGGTTATCCCGCAGAAAGTCTCGGAGCAGCCAGCTGAGCTCCCGACGCCTCCGCAGCAAGGACAGTGTAGAGAAGCTGGCTACAGT
GGTCGGGGAGAACGGCTCCGTCCTGCGGCGTGTGACCCGTGCTGCGGCTGCAGCTGCCGCGGCTACCATGGCATTGGCTGCACCTTCTTC
ACCCACCCCTGAGTCTCCCACGATGCTGACTAAGAAGCCCGAGGATAACCACACCCAGTGCCAGCTGGTGCCTGTGGTGGAGATCGGCAT
CAGTGAGCGCCAGAATGCTGAGCAGCATGTCACCCAGCTCATGTCCACCGAGCCTCTGCCCCGCACTCTGTCCCCGACTCCAGCTTCAGC
CACAGCTCCAACCTCCCAGGGCATCCCGACATCAGATGAGGAATCAACACCTAAGAAGTCGAAGGCCAGGATACTGGAGTCCATCACAGT
GAGCTCCCTGATGGCTACACCCCAGGACCCCAAGGGTCAAGGGGTCGGGACGGGGCGGTCTGCGTCTAAGCTCAGGATTGCGCAGGTCTC
CCCTGGCCCACGGGACTCGCCAGCCTTTCCAGATTCTCCATGGCGGGAGCGGGTGCTGGCTCCCATCCTGCCGGATAACTTCTCCACGCC
CACGGGCTCTCGCACGGACTCTCAATCGGTGCGGCACAGCCCGATCGCCCCGTCTTCCCCGAGTCCCCAAGTCTTAGCCCAGAAGTACTC
TCTGGTGGCCAAACAGGAAAGTGTTGTCCGCAGGGCGAGCAGAAGGCTTGCCAAGAAGACTGCCGAAGAGCCAGCTGCCTCTGGCCGCAT
CATCTGTCACAGTTACCTGGAGAGGCTCCTGAATGTTGAGGTGCCCCAGAAAGTTGGTTCTGAGCAGAAGGAACCCCCCGAGGAGGCTGA
GCCTGTGGCGGCAGCTGAGCCAGAGGTCCCTGAGAACAATGGAAATAACTCGTGGCCCCACAATGACACGGAGATTGCCAACAGCACACC
CAACCCGAAGCCTGCAGCCAGCAGCCCGGAAACACCCTCTGCAGGGCAGCAAGAGGCCAAGACGGACCAAGCAGATGGACCCAGAGAGCC
ACCGCAGAGTGCCAGGAGGAAGCGCAGCTACAAGCAGGCCGTGAGTGAGCTGGACGAGGAGCAGCACCTGGAGGATGAGGAGCTGCAGCC
CCCCAGGAGCAAGACCCCTTCCTCACCCTGCCCAGCCAGCAAGGTGGTACGGCCCCTCCGGACCTTTCTGCACACAGTGCAGAGGAACCA
GATGCTCATGACCCCGACCTCAGCCCCACGCAGCGTCATGAAGTCCTTTATTAAGCGCAACACTCCCCTGCGCATGGACCCCAAGTGCAG
CTTCGTCCACCGCGGAGACCTGGGCAATGTCCGTGCTGATGCTGACGGCCGCGCCATCTTCAGAATGGAGGATGAGCAGCTGAAGGTGTG
GGATGTGATTGGCCGCAGCCTGATTATTGATGAGGGAGAAGATGACCTGGGCCGGGGAGGCCATCCCTTATCCAAGATCACAGGGAACTC
CGGGGAGAGGTTGGCCTGTGGCATCATTGCACGCTCCGCTGGCCTTTTCCAGAACCCCAAGCAGATCTGCTCTTGCGATGGCCTCACCAT
CTGGGAGGAGCGAGGCCGGCCCATCGCTGGCAAGGGCCGAAAGGAGTCAGCGCAGCCCCCTGCCCACCTTTGAGCAGGACCTCACCTTGG
CTCTGTTGCTGTCCTCCAGGGCGAGCACTTTCCACTTCCAGAGGGGGCCAGAGGGACTTTGCCTGCCCAGTCTTTGGAGAGCTCAGTACA

>In-frame_ENST00000394818_ENST00000533244_TCGA-77-8153_INCENP_chr11_61908983_+_CCS_chr11_66372810_length(amino acids)=691AA_start in transcript=67_stop in transcript=2142
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHP

--------------------------------------------------------------
>In-frame_ENST00000394818_ENST00000310190_TCGA-77-8153_INCENP_chr11_61908983_+_CCS_chr11_66372810_length(transcript)=2207nt_BP=1807nt
CTTGCCGAGGATTGGCTGAGCCTTCAGTTTTGAAAATCATAGTTTTCGCCCGCGCTGCGCCGCCTGGTTGCTCCTCCCGTGCGGTGAGTC
CCGAAGGCCCGGAGCCAAGTGGGTCTGGGCAAGCGGGGCCTTACCTAGGGATACCACCGGACTTGGATCGGAGCAGCCTTCAGGGGACGT
GGCGCAGTCGAACAGAGCCACCATGGGGACGACGGCCCCAGGGCCCATTCACCTGCTGGAGCTATGTGACCAGAAGCTCATGGAGTTTCT
CTGCAACATGGATAATAAGGACTTGGTGTGGCTTGAGGAAATCCAAGAGGAGGCCGAGCGCATGTTCACCAGAGAATTCAGCAAAGAGCC
AGAGCTGATGCCCAAAACACCTTCTCAGAAGAACCGACGGAAGAAGAGACGGATTTCTTATGTTCAGGATGAAAACAGAGATCCCATCAG
GAGAAGGTTATCCCGCAGAAAGTCTCGGAGCAGCCAGCTGAGCTCCCGACGCCTCCGCAGCAAGGACAGTGTAGAGAAGCTGGCTACAGT
GGTCGGGGAGAACGGCTCCGTCCTGCGGCGTGTGACCCGTGCTGCGGCTGCAGCTGCCGCGGCTACCATGGCATTGGCTGCACCTTCTTC
ACCCACCCCTGAGTCTCCCACGATGCTGACTAAGAAGCCCGAGGATAACCACACCCAGTGCCAGCTGGTGCCTGTGGTGGAGATCGGCAT
CAGTGAGCGCCAGAATGCTGAGCAGCATGTCACCCAGCTCATGTCCACCGAGCCTCTGCCCCGCACTCTGTCCCCGACTCCAGCTTCAGC
CACAGCTCCAACCTCCCAGGGCATCCCGACATCAGATGAGGAATCAACACCTAAGAAGTCGAAGGCCAGGATACTGGAGTCCATCACAGT
GAGCTCCCTGATGGCTACACCCCAGGACCCCAAGGGTCAAGGGGTCGGGACGGGGCGGTCTGCGTCTAAGCTCAGGATTGCGCAGGTCTC
CCCTGGCCCACGGGACTCGCCAGCCTTTCCAGATTCTCCATGGCGGGAGCGGGTGCTGGCTCCCATCCTGCCGGATAACTTCTCCACGCC
CACGGGCTCTCGCACGGACTCTCAATCGGTGCGGCACAGCCCGATCGCCCCGTCTTCCCCGAGTCCCCAAGTCTTAGCCCAGAAGTACTC
TCTGGTGGCCAAACAGGAAAGTGTTGTCCGCAGGGCGAGCAGAAGGCTTGCCAAGAAGACTGCCGAAGAGCCAGCTGCCTCTGGCCGCAT
CATCTGTCACAGTTACCTGGAGAGGCTCCTGAATGTTGAGGTGCCCCAGAAAGTTGGTTCTGAGCAGAAGGAACCCCCCGAGGAGGCTGA
GCCTGTGGCGGCAGCTGAGCCAGAGGTCCCTGAGAACAATGGAAATAACTCGTGGCCCCACAATGACACGGAGATTGCCAACAGCACACC
CAACCCGAAGCCTGCAGCCAGCAGCCCGGAAACACCCTCTGCAGGGCAGCAAGAGGCCAAGACGGACCAAGCAGATGGACCCAGAGAGCC
ACCGCAGAGTGCCAGGAGGAAGCGCAGCTACAAGCAGGCCGTGAGTGAGCTGGACGAGGAGCAGCACCTGGAGGATGAGGAGCTGCAGCC
CCCCAGGAGCAAGACCCCTTCCTCACCCTGCCCAGCCAGCAAGGTGGTACGGCCCCTCCGGACCTTTCTGCACACAGTGCAGAGGAACCA
GATGCTCATGACCCCGACCTCAGCCCCACGCAGCGTCATGAAGTCCTTTATTAAGCGCAACACTCCCCTGCGCATGGACCCCAAGTGCAG
CTTCGTCCACCGCGGAGACCTGGGCAATGTCCGTGCTGATGCTGACGGCCGCGCCATCTTCAGAATGGAGGATGAGCAGCTGAAGGTGTG
GGATGTGATTGGCCGCAGCCTGATTATTGATGAGGGAGAAGATGACCTGGGCCGGGGAGGCCATCCCTTATCCAAGATCACAGGGAACTC
CGGGGAGAGGTTGGCCTGTGGCATCATTGCACGCTCCGCTGGCCTTTTCCAGAACCCCAAGCAGATCTGCTCTTGCGATGGCCTCACCAT
CTGGGAGGAGCGAGGCCGGCCCATCGCTGGCAAGGGCCGAAAGGAGTCAGCGCAGCCCCCTGCCCACCTTTGAGCAGGACCTCACCTTGG

>In-frame_ENST00000394818_ENST00000310190_TCGA-77-8153_INCENP_chr11_61908983_+_CCS_chr11_66372810_length(amino acids)=691AA_start in transcript=67_stop in transcript=2142
MLLPCGESRRPGAKWVWASGALPRDTTGLGSEQPSGDVAQSNRATMGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMF
TREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAAT
MALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKA
RILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSP
QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHND
TEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTF
LHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for INCENP-CCS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneINCENPchr11:61908516chr11:66372810ENST00000278849+1018124_248531.0915.0CBX5
HgeneINCENPchr11:61908516chr11:66372810ENST00000394818+1019124_248531.0919.0CBX5
HgeneINCENPchr11:61908983chr11:66372810ENST00000394818+1119124_248535.0919.0CBX5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneINCENPchr11:61908516chr11:66372810ENST00000278849+1018822_897531.0915.0AURKC
HgeneINCENPchr11:61908516chr11:66372810ENST00000394818+1019822_897531.0919.0AURKC
HgeneINCENPchr11:61908983chr11:66372810ENST00000278849+118822_8970915.0AURKC
HgeneINCENPchr11:61908983chr11:66372810ENST00000394818+1119822_897535.0919.0AURKC
HgeneINCENPchr11:61908983chr11:66372810ENST00000278849+118124_2480915.0CBX5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for INCENP-CCS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for INCENP-CCS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINCENPC0025202melanoma1CTD_human
HgeneINCENPC2931456Prostate cancer, familial1CTD_human
HgeneINCENPC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human
TgeneCCSC0019189Hepatitis, Chronic1CTD_human
TgeneCCSC0149519Chronic Persistent Hepatitis1CTD_human
TgeneCCSC0520463Chronic active hepatitis1CTD_human
TgeneCCSC0524611Cryptogenic Chronic Hepatitis1CTD_human