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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:INPP5B-SF3A3 (FusionGDB2 ID:39653)

Fusion Gene Summary for INPP5B-SF3A3

check button Fusion gene summary
Fusion gene informationFusion gene name: INPP5B-SF3A3
Fusion gene ID: 39653
HgeneTgene
Gene symbol

INPP5B

SF3A3

Gene ID

3633

10946

Gene nameinositol polyphosphate-5-phosphatase Bsplicing factor 3a subunit 3
Synonyms5PTasePRP9|PRPF9|SAP61|SF3a60
Cytomap

1p34.3

1p34.3

Type of geneprotein-codingprotein-coding
Descriptiontype II inositol 1,4,5-trisphosphate 5-phosphataseinositol polyphosphate-5-phosphatase, 75kDaphosphoinositide 5-phosphatasesplicing factor 3A subunit 3SAP 61pre-mRNA splicing factor SF3a (60kD)spliceosome associated protein 61splicing factor 3a, subunit 3, 60kDsplicing factor 3a, subunit 3, 60kDa
Modification date2020031320200313
UniProtAcc

P32019

.
Ensembl transtripts involved in fusion geneENST00000373023, ENST00000373026, 
ENST00000373024, ENST00000373021, 
ENST00000373027, ENST00000458109, 
ENST00000467066, 		ENST00000373019, 
ENST00000448721, ENST00000489537, 
Fusion gene scores* DoF score6 X 8 X 4=1927 X 8 X 5=280
# samples 911
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: INPP5B [Title/Abstract] AND SF3A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointINPP5B(38338602)-SF3A3(38435407), # samples:2
Anticipated loss of major functional domain due to fusion event.INPP5B-SF3A3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
INPP5B-SF3A3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
INPP5B-SF3A3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINPP5B

GO:0046856

phosphatidylinositol dephosphorylation

7721860

TgeneSF3A3

GO:0000398

mRNA splicing, via spliceosome

29360106

TgeneSF3A3

GO:1903241

U2-type prespliceosome assembly

11533230


check buttonFusion gene breakpoints across INPP5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SF3A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A26X-01AINPP5Bchr1

38397345

-SF3A3chr1

38425847

-
ChimerDB4LUADTCGA-78-8660-01AINPP5Bchr1

38338602

-SF3A3chr1

38435407

-
ChimerDB4LUADTCGA-78-8660INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
ChimerDB4LUADTCGA-78-8660-01AINPP5Bchr1

38338602

-SF3A3chr1

38435407

-


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Fusion Gene ORF analysis for INPP5B-SF3A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000373023ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
Frame-shiftENST00000373023ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
5CDS-intronENST00000373023ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
In-frameENST00000373026ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
In-frameENST00000373026ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
5CDS-intronENST00000373026ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000373024ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000373024ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-intronENST00000373024ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000373021ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000373021ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-intronENST00000373021ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
Frame-shiftENST00000373027ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
Frame-shiftENST00000373027ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
5CDS-intronENST00000373027ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000458109ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000458109ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-intronENST00000458109ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000467066ENST00000373019INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-3CDSENST00000467066ENST00000448721INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
intron-intronENST00000467066ENST00000489537INPP5Bchr1

38397345

-SF3A3chr1

38425847

-
Frame-shiftENST00000373023ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
Frame-shiftENST00000373023ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
5CDS-intronENST00000373023ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
In-frameENST00000373026ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
In-frameENST00000373026ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
5CDS-intronENST00000373026ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
Frame-shiftENST00000373024ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
Frame-shiftENST00000373024ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
5CDS-intronENST00000373024ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-3CDSENST00000373021ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-3CDSENST00000373021ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-intronENST00000373021ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
In-frameENST00000373027ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
In-frameENST00000373027ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
5CDS-intronENST00000373027ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-3CDSENST00000458109ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-3CDSENST00000458109ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-intronENST00000458109ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-3CDSENST00000467066ENST00000373019INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-3CDSENST00000467066ENST00000448721INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
intron-intronENST00000467066ENST00000489537INPP5Bchr1

38338602

-SF3A3chr1

38435407

-
Frame-shiftENST00000373023ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
Frame-shiftENST00000373023ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
5CDS-intronENST00000373023ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
In-frameENST00000373026ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
In-frameENST00000373026ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
5CDS-intronENST00000373026ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
Frame-shiftENST00000373024ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
Frame-shiftENST00000373024ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
5CDS-intronENST00000373024ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-3CDSENST00000373021ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-3CDSENST00000373021ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-intronENST00000373021ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
In-frameENST00000373027ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
In-frameENST00000373027ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
5CDS-intronENST00000373027ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-3CDSENST00000458109ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-3CDSENST00000458109ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-intronENST00000458109ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-3CDSENST00000467066ENST00000373019INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-3CDSENST00000467066ENST00000448721INPP5Bchr1

38338601

-SF3A3chr1

38435407

-
intron-intronENST00000467066ENST00000489537INPP5Bchr1

38338601

-SF3A3chr1

38435407

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for INPP5B-SF3A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for INPP5B-SF3A3


check button Go to

FGviewer for the breakpoints of chr1:38397345-chr1:38425847

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INPP5B

P32019

.
FUNCTION: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269|PubMed:7721860}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-192422_148809.0994.0DomainNote=PH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-192422_148729.0914.0DomainNote=PH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-182322_148809.0994.0DomainNote=PH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-131822_148565.0750.0DomainNote=PH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-192422_148809.0994.0DomainNote=PH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-192422_148729.0914.0DomainNote=PH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-182322_148809.0994.0DomainNote=PH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-131822_148565.0750.0DomainNote=PH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-72422_148257.3333333333333994.0DomainNote=PH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-62322_148257.3333333333333994.0DomainNote=PH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-1924342_668809.0994.0Region5-phosphatase
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-1924459_460809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-1924582_583809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-1924596_598809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-1924669_782809.0994.0RegionASH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-1924342_668729.0914.0Region5-phosphatase
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-1924459_460729.0914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-1924582_583729.0914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-1924596_598729.0914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-1823342_668809.0994.0Region5-phosphatase
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-1823459_460809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-1823582_583809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-1823596_598809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-1823669_782809.0994.0RegionASH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-1318459_460565.0750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-1924342_668809.0994.0Region5-phosphatase
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-1924459_460809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-1924582_583809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-1924596_598809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-1924669_782809.0994.0RegionASH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-1924342_668729.0914.0Region5-phosphatase
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-1924459_460729.0914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-1924582_583729.0914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-1924596_598729.0914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-1823342_668809.0994.0Region5-phosphatase
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-1823459_460809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-1823582_583809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-1823596_598809.0994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-1823669_782809.0994.0RegionASH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-1318459_460565.0750.0RegionNote=Substrate binding
TgeneSF3A3chr1:38338601chr1:38435407ENST000003730191117354_362335.0502.0Compositional biasNote=Poly-Glu
TgeneSF3A3chr1:38338602chr1:38435407ENST000003730191117354_362335.0502.0Compositional biasNote=Poly-Glu
TgeneSF3A3chr1:38338601chr1:38435407ENST000003730191117406_437335.0502.0Zinc fingerMatrin-type
TgeneSF3A3chr1:38338602chr1:38435407ENST000003730191117406_437335.0502.0Zinc fingerMatrin-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373023-1924821_993809.0994.0DomainRho-GAP
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-1924821_993729.0914.0DomainRho-GAP
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373026-1823821_993809.0994.0DomainRho-GAP
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-1318821_993565.0750.0DomainRho-GAP
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373023-1924821_993809.0994.0DomainRho-GAP
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-1924821_993729.0914.0DomainRho-GAP
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373026-1823821_993809.0994.0DomainRho-GAP
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-1318821_993565.0750.0DomainRho-GAP
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-724821_993257.3333333333333994.0DomainRho-GAP
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-12422_1480914.0DomainNote=PH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-124821_9930914.0DomainRho-GAP
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-623821_993257.3333333333333994.0DomainRho-GAP
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-11822_14813.333333333333334750.0DomainNote=PH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-118821_99313.333333333333334750.0DomainRho-GAP
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373024-1924669_782729.0914.0RegionASH
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-1318342_668565.0750.0Region5-phosphatase
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-1318582_583565.0750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-1318596_598565.0750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338601chr1:38435407ENST00000373027-1318669_782565.0750.0RegionASH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373024-1924669_782729.0914.0RegionASH
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-1318342_668565.0750.0Region5-phosphatase
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-1318582_583565.0750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-1318596_598565.0750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38338602chr1:38435407ENST00000373027-1318669_782565.0750.0RegionASH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-724342_668257.3333333333333994.0Region5-phosphatase
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-724459_460257.3333333333333994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-724582_583257.3333333333333994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-724596_598257.3333333333333994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373023-724669_782257.3333333333333994.0RegionASH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-124342_6680914.0Region5-phosphatase
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-124459_4600914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-124582_5830914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-124596_5980914.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373024-124669_7820914.0RegionASH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-623342_668257.3333333333333994.0Region5-phosphatase
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-623459_460257.3333333333333994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-623582_583257.3333333333333994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-623596_598257.3333333333333994.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373026-623669_782257.3333333333333994.0RegionASH
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-118342_66813.333333333333334750.0Region5-phosphatase
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-118459_46013.333333333333334750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-118582_58313.333333333333334750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-118596_59813.333333333333334750.0RegionNote=Substrate binding
HgeneINPP5Bchr1:38397345chr1:38425847ENST00000373027-118669_78213.333333333333334750.0RegionASH
TgeneSF3A3chr1:38397345chr1:38425847ENST000003730191417354_362457.3333333333333502.0Compositional biasNote=Poly-Glu
TgeneSF3A3chr1:38338601chr1:38435407ENST000003730191117175_179335.0502.0MotifNuclear localization signal
TgeneSF3A3chr1:38338602chr1:38435407ENST000003730191117175_179335.0502.0MotifNuclear localization signal
TgeneSF3A3chr1:38397345chr1:38425847ENST000003730191417175_179457.3333333333333502.0MotifNuclear localization signal
TgeneSF3A3chr1:38397345chr1:38425847ENST000003730191417406_437457.3333333333333502.0Zinc fingerMatrin-type


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Fusion Gene Sequence for INPP5B-SF3A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for INPP5B-SF3A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for INPP5B-SF3A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for INPP5B-SF3A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSF3A3C0019693HIV Infections1CTD_human
TgeneSF3A3C4505456HIV Coinfection1CTD_human