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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:INTS4-NDUFC2 (FusionGDB2 ID:39782)

Fusion Gene Summary for INTS4-NDUFC2

check button Fusion gene summary
Fusion gene informationFusion gene name: INTS4-NDUFC2
Fusion gene ID: 39782
HgeneTgene
Gene symbol

INTS4

NDUFC2

Gene ID

92105

4718

Gene nameintegrator complex subunit 4NADH:ubiquinone oxidoreductase subunit C2
SynonymsINT4|MST093B14.5b|CI-B14.5b|HLC-1|NADHDH2
Cytomap

11q14.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionintegrator complex subunit 4MSTP093NADH dehydrogenase [ubiquinone] 1 subunit C2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDaNADH-ubiquinone oxidoreductase subunit B14.5bcomplex I subunit B14.5bcomplex I-B14.5bhuman lung cancer oncogene 1 protein
Modification date2020031320200313
UniProtAcc

Q96HW7

E9PQ53

Ensembl transtripts involved in fusion geneENST00000534064, ENST00000535943, 
ENST00000525931, ENST00000529807, 
ENST00000527522, 		ENST00000281031, 
ENST00000527806, ENST00000534029, 
ENST00000525085, ENST00000528164, 
Fusion gene scores* DoF score21 X 14 X 10=29404 X 1 X 4=16
# samples 295
** MAII scorelog2(29/2940*10)=-3.34169134970879
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: INTS4 [Title/Abstract] AND NDUFC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointINTS4(77594878)-NDUFC2(77784187), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneINTS4

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across INTS4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NDUFC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A1Y5-01AINTS4chr11

77594878

-NDUFC2chr11

77784187

-


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Fusion Gene ORF analysis for INTS4-NDUFC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000534064ENST00000281031INTS4chr11

77594878

-NDUFC2chr11

77784187

-
In-frameENST00000534064ENST00000527806INTS4chr11

77594878

-NDUFC2chr11

77784187

-
5CDS-intronENST00000534064ENST00000534029INTS4chr11

77594878

-NDUFC2chr11

77784187

-
5CDS-intronENST00000534064ENST00000525085INTS4chr11

77594878

-NDUFC2chr11

77784187

-
5CDS-intronENST00000534064ENST00000528164INTS4chr11

77594878

-NDUFC2chr11

77784187

-
In-frameENST00000535943ENST00000281031INTS4chr11

77594878

-NDUFC2chr11

77784187

-
In-frameENST00000535943ENST00000527806INTS4chr11

77594878

-NDUFC2chr11

77784187

-
5CDS-intronENST00000535943ENST00000534029INTS4chr11

77594878

-NDUFC2chr11

77784187

-
5CDS-intronENST00000535943ENST00000525085INTS4chr11

77594878

-NDUFC2chr11

77784187

-
5CDS-intronENST00000535943ENST00000528164INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-3CDSENST00000525931ENST00000281031INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-3CDSENST00000525931ENST00000527806INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000525931ENST00000534029INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000525931ENST00000525085INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000525931ENST00000528164INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-3CDSENST00000529807ENST00000281031INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-3CDSENST00000529807ENST00000527806INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000529807ENST00000534029INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000529807ENST00000525085INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000529807ENST00000528164INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-3CDSENST00000527522ENST00000281031INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-3CDSENST00000527522ENST00000527806INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000527522ENST00000534029INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000527522ENST00000525085INTS4chr11

77594878

-NDUFC2chr11

77784187

-
intron-intronENST00000527522ENST00000528164INTS4chr11

77594878

-NDUFC2chr11

77784187

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534064INTS4chr1177594878-ENST00000281031NDUFC2chr1177784187-46252748352941968
ENST00000534064INTS4chr1177594878-ENST00000527806NDUFC2chr1177784187-43732748352848937
ENST00000535943INTS4chr1177594878-ENST00000281031NDUFC2chr1177784187-28539761381169343
ENST00000535943INTS4chr1177594878-ENST00000527806NDUFC2chr1177784187-26019761381076312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534064ENST00000281031INTS4chr1177594878-NDUFC2chr1177784187-0.0009186420.9990814
ENST00000534064ENST00000527806INTS4chr1177594878-NDUFC2chr1177784187-0.001256830.99874324
ENST00000535943ENST00000281031INTS4chr1177594878-NDUFC2chr1177784187-0.0006204040.9993795
ENST00000535943ENST00000527806INTS4chr1177594878-NDUFC2chr1177784187-0.001035630.9989643

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Fusion Genomic Features for INTS4-NDUFC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for INTS4-NDUFC2


check button Go to

FGviewer for the breakpoints of chr11:77594878-chr11:77784187

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
INTS4

Q96HW7

NDUFC2

E9PQ53

FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223145_183904.3333333333334964.0RepeatNote=HEAT 2
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223190_228904.3333333333334964.0RepeatNote=HEAT 3
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223229_263904.3333333333334964.0RepeatNote=HEAT 4
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223277_313904.3333333333334964.0RepeatNote=HEAT 5
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223369_405904.3333333333334964.0RepeatNote=HEAT 6
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223406_444904.3333333333334964.0RepeatNote=HEAT 7
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-2223446_484904.3333333333334964.0RepeatNote=HEAT 8
HgeneINTS4chr11:77594878chr11:77784187ENST00000534064-222366_105904.3333333333334964.0RepeatNote=HEAT 1
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89145_183279.3333333333333339.0RepeatNote=HEAT 2
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89190_228279.3333333333333339.0RepeatNote=HEAT 3
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89229_263279.3333333333333339.0RepeatNote=HEAT 4
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-8966_105279.3333333333333339.0RepeatNote=HEAT 1
TgeneNDUFC2chr11:77594878chr11:77784187ENST000002810310356_7555.333333333333336120.0TransmembraneHelical
TgeneNDUFC2chr11:77594878chr11:77784187ENST000005250850356_75097.0TransmembraneHelical
TgeneNDUFC2chr11:77594878chr11:77784187ENST000005278060356_7555.33333333333333689.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112145_1830506.0RepeatNote=HEAT 2
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112190_2280506.0RepeatNote=HEAT 3
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112229_2630506.0RepeatNote=HEAT 4
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112277_3130506.0RepeatNote=HEAT 5
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112369_4050506.0RepeatNote=HEAT 6
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112406_4440506.0RepeatNote=HEAT 7
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-112446_4840506.0RepeatNote=HEAT 8
HgeneINTS4chr11:77594878chr11:77784187ENST00000529807-11266_1050506.0RepeatNote=HEAT 1
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89277_313279.3333333333333339.0RepeatNote=HEAT 5
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89369_405279.3333333333333339.0RepeatNote=HEAT 6
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89406_444279.3333333333333339.0RepeatNote=HEAT 7
HgeneINTS4chr11:77594878chr11:77784187ENST00000535943-89446_484279.3333333333333339.0RepeatNote=HEAT 8


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Fusion Gene Sequence for INTS4-NDUFC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000534064_ENST00000281031_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(transcript)=4625nt_BP=2748nt
TAGTGTACGGAAGCTGAGAGGGCCCGCGGGTAGGCATGGCGGCGCACCTTAAGAAGCGGGTTTATGAGGAATTCACGAAAGTGGTTCAGC
CACAGGAGGAAATTGCTACTAAGAAACTCCGACTAACAAAACCAAGTAAATCTGCAGCACTCCACATAGATCTGTGTAAAGCTACCTCCC
CAGCAGATGCTTTGCAATACTTGCTCCAGTTTGCCAGGAAGCCTGTCGAGGCGGAAAGCGTAGAGGGAGTAGTCAGGATTCTCTTGGAAC
ATTATTACAAGGAGAATGATCCATCTGTGAGACTGAAAATTGCATCATTGTTGGGTTTATTATCAAAGACAGCAGGATTTTCACCAGACT
GCATTATGGATGATGCCATCAACATCCTGCAGAATGAAAAGTCTCATCAAGTCCTAGCTCAACTGCTGGATACTTTGCTTGCAATTGGCA
CTAAGCTACCAGAGAATCAAGCTATCCAAATGCGATTAGTTGATGTGGCCTGCAAGCATCTGACAGATACGTCTCATGGTGTAAGAAATA
AGTGCCTGCAGTTACTTGGCAATCTTGGCTCTTTGGAGAAAAGTGTCACAAAAGATGCAGAAGGCCTAGCTGCCAGAGATGTCCAGAAGA
TTATAGGGGATTACTTCAGTGACCAAGACCCACGTGTCAGAACAGCAGCTATAAAAGCCATGTTGCAGCTCCATGAAAGAGGACTGAAAT
TACACCAAACAATTTATAATCAGGCCTGTAAATTACTCTCTGATGACTATGAACAAGTGCGCAGTGCTGCAGTCCAGCTTATCTGGGTCG
TCAGTCAGCTCTATCCTGAAAGCATTGTCCCAATTCCTTCTTCTAATGAAGAAATACGCTTAGTTGATGATGCGTTTGGCAAAATTTGTC
ACATGGTCAGTGATGGCTCTTGGGTGGTTCGTGTTCAGGCAGCAAAACTGTTGGGCTCTATGGAGCAAGTCAGTTCTCATTTCTTGGAGC
AGACCCTTGACAAGAAGCTGATGTCAGATCTGAGGAGGAAACGTACTGCACATGAGCGTGCCAAGGAACTTTACAGTTCGGGGGAGTTTT
CCAGTGGCAGAAAGTGGGGAGATGATGCTCCCAAGGAAGAAGTAGATACCGGGGCTGTGAACTTGATTGAGTCAGGAGCTTGTGGAGCTT
TTGTTCATGGGTTGGAAGATGAGATGTATGAGGTTCGTATTGCTGCTGTGGAGGCCCTCTGCATGTTGGCCCAGTCTTCACCCTCTTTTG
CTGAGAAGTGCCTTGATTTCCTAGTTGACATGTTCAACGATGAAATTGAGGAAGTACGTCTGCAGTCTATACATACCATGAGAAAAATCT
CTAACAACATCACCCTCCGAGAAGATCAGCTTGACACTGTCCTGGCTGTGCTAGAGGATTCATCCAGAGATATTCGAGAGGCTCTTCATG
AACTCTTATGCTGTACTAATGTTTCAACCAAAGAAGGGATTCATCTTGCATTGGTGGAGCTGCTGAAAAATTTAACCAAGTACCCTACTG
ATAGGGACTCCATATGGAAGTGCTTGAAGTTTCTGGGAAGTCGGCATCCAACCCTGGTGCTTCCCTTGGTGCCAGAGCTTCTGAGCACCC
ACCCATTTTTTGACACAGCTGAACCAGACATGGATGATCCAGCTTATATTGCAGTTTTGGTACTTATTTTCAATGCTGCTAAAACCTGTC
CAACAATGCCAGCATTGTTCTCAGATCACACCTTCAGGCACTATGCCTACCTCCGAGACAGTCTTTCTCATCTTGTTCCTGCCTTGAGGT
TACCAGGTAGAAAACTGGTGTCATCAGCTGTTTCTCCCAGCATCATACCTCAAGAGGATCCTTCCCAGCAGTTCCTGCAGCAGAGCCTTG
AAAGAGTGTATAGTCTTCAGCACTTGGACCCTCAGGGAGCCCAGGAGCTGCTGGAATTCACCATCAGGGATCTGCAAAGACTTGGAGAAC
TTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTATCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGT
GGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGCCTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAAT
TCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACATCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCAC
GAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAAATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATT
TGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCTTATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTC
TACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCTTCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGG
GCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGTTGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGA
ACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGC
GGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGGTTTGCATCGCCAGCTTCTATATATTACGGCCTTTTTTTTTG
CTGGATATTATCTTGTAAAACGTGAAGACTACCTGTATGCTGTGAGGGACCGTGAAATGTTTGGATATATGAAATTACATCCAGAGGATT
TTCCTGAAGAAGATAAGAAAACATATGGTGAAATTTTTGAAAAATTCCATCCAATACGTTGAAGTCTTCAAAATGCTTGCTCCAGTTTCA
CTGATACCTGCTGTTTCTGAATTTGATGGAACATGTTTCTTATGACAGTTGAAGCTTATGCTAATCTGTATGTTGACACCTTGTAATTAA
AATACGTACCATGAGTACTCTGACTCTTTATTGTTGTAAGAAAAATAGTTCATCATCAGAGAATGGTCAGTTTCCATTCACCCATCTGAA
AGATTTTAAGATGAGGTTGAATTCTAGTTTAGAGTTAGCAGACTACCCAAATCTGGCCCACTGCCAATAAAGTCTCATTGGAACACAGCC
ATGCTCATTTGTTTACATGTTGTTTATGGCGACTGCCATGCTGCAAGAGCAGAATTGAGTAGTTGTGATAGAGACCTATGGCCTGCAAAG
CCTAATTAATATGTAGCCCTTTCAGAAAAGGTTTGCCTGCCCCTGTCCTAGTGCAAAGTGAATTTAGAGTGAGCCAGATTATGGAGGATT
CTGTGACTCTTGCCAAATAATTTTGACTTCATCCTGTAGGTATTAAGTCATTAAGGCGTTTTAAATCATACAGTCAGGTTTGTATTTCTG
AGCTGTCTATAATGAATGATATAGAAGGTGGTTTCGAAGGAGGAGACTCCAGACAAGGAAAACAGAAATCTTATGTTGCCAAGTTGTCTT
TGCTCTTAGGTGGGTTATCCTGGAGAAAATGGACTCAGGAGCTAATACTGTCTACAGTGGAGCTTGGTGCAATTAGAAGCAAAAGACTGT
ACCTAACTGGAATGAGGTTACTTTTTATGGCTTATCAAATGCTTGTCCTGGCCCGATGCAGTGGCTCATGCCTGTAATCCCAGCACTTTG
AGAGGCTGAGGCAGGGCAGATTGCATGAGCCCAGGAGTTCGAGACCAACTTGGGCAACATGGTGAAACACTGTCTCTACATAAAATACAA
AAATTAGCTGGGCGTGGTGGCACGTTCCTGCAATCCCAGCTACTCATAAGGCTGAGGTGGGAGGATCTATTGAGCCCTGGAATTCGAGGA
TGCAATTAATTGTGGTTGTGTCACAGTTCACTGCAGCCTGGGTGACACTCCAGCCTGGGTGACAAAGGAGACCCCGTCAAAAAAAAAAGT
ACTTGTCCCAAAAGTTTTTGTTTCCTAGCTTAGAATTTATAATCAGATTAGGTTTTGGAGATAAAGTATATGTGGTATTTTTTTTTTTTT
TTTTGAGACGACAGTCTTGCTCTGTCATCAGGCTGGAGTGCAGTGGCGCAATTTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCA
ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCATGCCACGACGCCCAGCTGATTTTTGTGTTTTTAGTAGAGACGGGGT
TTCACCATGTTGGCCAAGATGGTCTCAATCTCTTGACCTTGTGATCCACCTGCCTTGGCCTTCCAAAGTGTTGGAATTACAGGCGTGAGC
CACCGCGCCTGGTCTATATGTGATTTCAAATTAGGTGGCCTTATAAATATAAGCAGATGGTTTCTGGGCAAAATCAAATGATTTCTGTCT
CTATTTTCTTGAGTACCAATTGTAAAAACTGAAATTAGGTTGAGGAAAGTGCTTTAGAAATAATAAAGATGTACAAATACAAGGCTTTGG

>In-frame_ENST00000534064_ENST00000281031_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(amino acids)=968AA_start in transcript=35_stop in transcript=2941
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRL
KIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPI
PSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLD
TVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQ
GAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLH
LPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH

--------------------------------------------------------------
>In-frame_ENST00000534064_ENST00000527806_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(transcript)=4373nt_BP=2748nt
TAGTGTACGGAAGCTGAGAGGGCCCGCGGGTAGGCATGGCGGCGCACCTTAAGAAGCGGGTTTATGAGGAATTCACGAAAGTGGTTCAGC
CACAGGAGGAAATTGCTACTAAGAAACTCCGACTAACAAAACCAAGTAAATCTGCAGCACTCCACATAGATCTGTGTAAAGCTACCTCCC
CAGCAGATGCTTTGCAATACTTGCTCCAGTTTGCCAGGAAGCCTGTCGAGGCGGAAAGCGTAGAGGGAGTAGTCAGGATTCTCTTGGAAC
ATTATTACAAGGAGAATGATCCATCTGTGAGACTGAAAATTGCATCATTGTTGGGTTTATTATCAAAGACAGCAGGATTTTCACCAGACT
GCATTATGGATGATGCCATCAACATCCTGCAGAATGAAAAGTCTCATCAAGTCCTAGCTCAACTGCTGGATACTTTGCTTGCAATTGGCA
CTAAGCTACCAGAGAATCAAGCTATCCAAATGCGATTAGTTGATGTGGCCTGCAAGCATCTGACAGATACGTCTCATGGTGTAAGAAATA
AGTGCCTGCAGTTACTTGGCAATCTTGGCTCTTTGGAGAAAAGTGTCACAAAAGATGCAGAAGGCCTAGCTGCCAGAGATGTCCAGAAGA
TTATAGGGGATTACTTCAGTGACCAAGACCCACGTGTCAGAACAGCAGCTATAAAAGCCATGTTGCAGCTCCATGAAAGAGGACTGAAAT
TACACCAAACAATTTATAATCAGGCCTGTAAATTACTCTCTGATGACTATGAACAAGTGCGCAGTGCTGCAGTCCAGCTTATCTGGGTCG
TCAGTCAGCTCTATCCTGAAAGCATTGTCCCAATTCCTTCTTCTAATGAAGAAATACGCTTAGTTGATGATGCGTTTGGCAAAATTTGTC
ACATGGTCAGTGATGGCTCTTGGGTGGTTCGTGTTCAGGCAGCAAAACTGTTGGGCTCTATGGAGCAAGTCAGTTCTCATTTCTTGGAGC
AGACCCTTGACAAGAAGCTGATGTCAGATCTGAGGAGGAAACGTACTGCACATGAGCGTGCCAAGGAACTTTACAGTTCGGGGGAGTTTT
CCAGTGGCAGAAAGTGGGGAGATGATGCTCCCAAGGAAGAAGTAGATACCGGGGCTGTGAACTTGATTGAGTCAGGAGCTTGTGGAGCTT
TTGTTCATGGGTTGGAAGATGAGATGTATGAGGTTCGTATTGCTGCTGTGGAGGCCCTCTGCATGTTGGCCCAGTCTTCACCCTCTTTTG
CTGAGAAGTGCCTTGATTTCCTAGTTGACATGTTCAACGATGAAATTGAGGAAGTACGTCTGCAGTCTATACATACCATGAGAAAAATCT
CTAACAACATCACCCTCCGAGAAGATCAGCTTGACACTGTCCTGGCTGTGCTAGAGGATTCATCCAGAGATATTCGAGAGGCTCTTCATG
AACTCTTATGCTGTACTAATGTTTCAACCAAAGAAGGGATTCATCTTGCATTGGTGGAGCTGCTGAAAAATTTAACCAAGTACCCTACTG
ATAGGGACTCCATATGGAAGTGCTTGAAGTTTCTGGGAAGTCGGCATCCAACCCTGGTGCTTCCCTTGGTGCCAGAGCTTCTGAGCACCC
ACCCATTTTTTGACACAGCTGAACCAGACATGGATGATCCAGCTTATATTGCAGTTTTGGTACTTATTTTCAATGCTGCTAAAACCTGTC
CAACAATGCCAGCATTGTTCTCAGATCACACCTTCAGGCACTATGCCTACCTCCGAGACAGTCTTTCTCATCTTGTTCCTGCCTTGAGGT
TACCAGGTAGAAAACTGGTGTCATCAGCTGTTTCTCCCAGCATCATACCTCAAGAGGATCCTTCCCAGCAGTTCCTGCAGCAGAGCCTTG
AAAGAGTGTATAGTCTTCAGCACTTGGACCCTCAGGGAGCCCAGGAGCTGCTGGAATTCACCATCAGGGATCTGCAAAGACTTGGAGAAC
TTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTATCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGT
GGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGCCTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAAT
TCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACATCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCAC
GAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAAATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATT
TGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCTTATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTC
TACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCTTCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGG
GCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGTTGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGA
ACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGC
GGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGGTTTGCATCGCCAGCTTCTATATATTACGGCCTTTTTTTTTG
CTGGATATTATCTTGTAAAACTTGAAGCTTATGCTAATCTGTATGTTGACACCTTGTAATTAAAATACGTACCATGAGTACTCTGACTCT
TTATTGTTGTAAGAAAAATAGTTCATCATCAGAGAATGGTCAGTTTCCATTCACCCATCTGAAAGATTTTAAGATGAGGTTGAATTCTAG
TTTAGAGTTAGCAGACTACCCAAATCTGGCCCACTGCCAATAAAGTCTCATTGGAACACAGCCATGCTCATTTGTTTACATGTTGTTTAT
GGCGACTGCCATGCTGCAAGAGCAGAATTGAGTAGTTGTGATAGAGACCTATGGCCTGCAAAGCCTAATTAATATGTAGCCCTTTCAGAA
AAGGTTTGCCTGCCCCTGTCCTAGTGCAAAGTGAATTTAGAGTGAGCCAGATTATGGAGGATTCTGTGACTCTTGCCAAATAATTTTGAC
TTCATCCTGTAGGTATTAAGTCATTAAGGCGTTTTAAATCATACAGTCAGGTTTGTATTTCTGAGCTGTCTATAATGAATGATATAGAAG
GTGGTTTCGAAGGAGGAGACTCCAGACAAGGAAAACAGAAATCTTATGTTGCCAAGTTGTCTTTGCTCTTAGGTGGGTTATCCTGGAGAA
AATGGACTCAGGAGCTAATACTGTCTACAGTGGAGCTTGGTGCAATTAGAAGCAAAAGACTGTACCTAACTGGAATGAGGTTACTTTTTA
TGGCTTATCAAATGCTTGTCCTGGCCCGATGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGCAGGGCAGATTGCATG
AGCCCAGGAGTTCGAGACCAACTTGGGCAACATGGTGAAACACTGTCTCTACATAAAATACAAAAATTAGCTGGGCGTGGTGGCACGTTC
CTGCAATCCCAGCTACTCATAAGGCTGAGGTGGGAGGATCTATTGAGCCCTGGAATTCGAGGATGCAATTAATTGTGGTTGTGTCACAGT
TCACTGCAGCCTGGGTGACACTCCAGCCTGGGTGACAAAGGAGACCCCGTCAAAAAAAAAAGTACTTGTCCCAAAAGTTTTTGTTTCCTA
GCTTAGAATTTATAATCAGATTAGGTTTTGGAGATAAAGTATATGTGGTATTTTTTTTTTTTTTTTTGAGACGACAGTCTTGCTCTGTCA
TCAGGCTGGAGTGCAGTGGCGCAATTTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAG
CTGGGACTACAGGTGCATGCCACGACGCCCAGCTGATTTTTGTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAAGATGGTCTCA
ATCTCTTGACCTTGTGATCCACCTGCCTTGGCCTTCCAAAGTGTTGGAATTACAGGCGTGAGCCACCGCGCCTGGTCTATATGTGATTTC
AAATTAGGTGGCCTTATAAATATAAGCAGATGGTTTCTGGGCAAAATCAAATGATTTCTGTCTCTATTTTCTTGAGTACCAATTGTAAAA

>In-frame_ENST00000534064_ENST00000527806_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(amino acids)=937AA_start in transcript=35_stop in transcript=2848
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRL
KIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPI
PSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLD
TVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQ
GAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLH
LPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH

--------------------------------------------------------------
>In-frame_ENST00000535943_ENST00000281031_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(transcript)=2853nt_BP=976nt
AGGCATCTCCTTCTTGATGTCAAAGTCCCCAGGAGGCATCGTTAACTATCGTAACGTTACCTGCCGAGCATGAGATGGGAGGAAGTGTCA
TAGTCCAGTGGACGGTTTTTTCCAGGCTACTGTGAAACCTGATGTGTTATGCCGGCCCTGAAACAGACAGCTTCCCAAGTGACTCAGACC
TTAAGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTATCTTCGCTGTCAACTACTT
CTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGCCTCAGCAGCAGCGAAACAG
ATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACATCACATGAGGCTGCAGGCC
AAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAAATTTTTACAGGAAGTAGAC
TTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCTTATGCCCCGACTCATGACA
TCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCTTCCAGAGCAGATCCACAAA
GCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGTTGCCCTGGATGTTGATGCA
ACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCT
GCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGGTTTGCATCGCCAG
CTTCTATATATTACGGCCTTTTTTTTTGCTGGATATTATCTTGTAAAACGTGAAGACTACCTGTATGCTGTGAGGGACCGTGAAATGTTT
GGATATATGAAATTACATCCAGAGGATTTTCCTGAAGAAGATAAGAAAACATATGGTGAAATTTTTGAAAAATTCCATCCAATACGTTGA
AGTCTTCAAAATGCTTGCTCCAGTTTCACTGATACCTGCTGTTTCTGAATTTGATGGAACATGTTTCTTATGACAGTTGAAGCTTATGCT
AATCTGTATGTTGACACCTTGTAATTAAAATACGTACCATGAGTACTCTGACTCTTTATTGTTGTAAGAAAAATAGTTCATCATCAGAGA
ATGGTCAGTTTCCATTCACCCATCTGAAAGATTTTAAGATGAGGTTGAATTCTAGTTTAGAGTTAGCAGACTACCCAAATCTGGCCCACT
GCCAATAAAGTCTCATTGGAACACAGCCATGCTCATTTGTTTACATGTTGTTTATGGCGACTGCCATGCTGCAAGAGCAGAATTGAGTAG
TTGTGATAGAGACCTATGGCCTGCAAAGCCTAATTAATATGTAGCCCTTTCAGAAAAGGTTTGCCTGCCCCTGTCCTAGTGCAAAGTGAA
TTTAGAGTGAGCCAGATTATGGAGGATTCTGTGACTCTTGCCAAATAATTTTGACTTCATCCTGTAGGTATTAAGTCATTAAGGCGTTTT
AAATCATACAGTCAGGTTTGTATTTCTGAGCTGTCTATAATGAATGATATAGAAGGTGGTTTCGAAGGAGGAGACTCCAGACAAGGAAAA
CAGAAATCTTATGTTGCCAAGTTGTCTTTGCTCTTAGGTGGGTTATCCTGGAGAAAATGGACTCAGGAGCTAATACTGTCTACAGTGGAG
CTTGGTGCAATTAGAAGCAAAAGACTGTACCTAACTGGAATGAGGTTACTTTTTATGGCTTATCAAATGCTTGTCCTGGCCCGATGCAGT
GGCTCATGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGCAGGGCAGATTGCATGAGCCCAGGAGTTCGAGACCAACTTGGGCAACATGG
TGAAACACTGTCTCTACATAAAATACAAAAATTAGCTGGGCGTGGTGGCACGTTCCTGCAATCCCAGCTACTCATAAGGCTGAGGTGGGA
GGATCTATTGAGCCCTGGAATTCGAGGATGCAATTAATTGTGGTTGTGTCACAGTTCACTGCAGCCTGGGTGACACTCCAGCCTGGGTGA
CAAAGGAGACCCCGTCAAAAAAAAAAGTACTTGTCCCAAAAGTTTTTGTTTCCTAGCTTAGAATTTATAATCAGATTAGGTTTTGGAGAT
AAAGTATATGTGGTATTTTTTTTTTTTTTTTTGAGACGACAGTCTTGCTCTGTCATCAGGCTGGAGTGCAGTGGCGCAATTTCGGCTCAC
TGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCATGCCACGACGCCCAGCTG
ATTTTTGTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAAGATGGTCTCAATCTCTTGACCTTGTGATCCACCTGCCTTGGCCTT
CCAAAGTGTTGGAATTACAGGCGTGAGCCACCGCGCCTGGTCTATATGTGATTTCAAATTAGGTGGCCTTATAAATATAAGCAGATGGTT
TCTGGGCAAAATCAAATGATTTCTGTCTCTATTTTCTTGAGTACCAATTGTAAAAACTGAAATTAGGTTGAGGAAAGTGCTTTAGAAATA

>In-frame_ENST00000535943_ENST00000281031_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(amino acids)=343AA_start in transcript=138_stop in transcript=1169
MPALKQTASQVTQTLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVE
NKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQ
SAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQ

--------------------------------------------------------------
>In-frame_ENST00000535943_ENST00000527806_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(transcript)=2601nt_BP=976nt
AGGCATCTCCTTCTTGATGTCAAAGTCCCCAGGAGGCATCGTTAACTATCGTAACGTTACCTGCCGAGCATGAGATGGGAGGAAGTGTCA
TAGTCCAGTGGACGGTTTTTTCCAGGCTACTGTGAAACCTGATGTGTTATGCCGGCCCTGAAACAGACAGCTTCCCAAGTGACTCAGACC
TTAAGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTATCTTCGCTGTCAACTACTT
CTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGCCTCAGCAGCAGCGAAACAG
ATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACATCACATGAGGCTGCAGGCC
AAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAAATTTTTACAGGAAGTAGAC
TTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCTTATGCCCCGACTCATGACA
TCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCTTCCAGAGCAGATCCACAAA
GCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGTTGCCCTGGATGTTGATGCA
ACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCAGATGATTCACCCCAAGCCT
GCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGGTTTGCATCGCCAG
CTTCTATATATTACGGCCTTTTTTTTTGCTGGATATTATCTTGTAAAACTTGAAGCTTATGCTAATCTGTATGTTGACACCTTGTAATTA
AAATACGTACCATGAGTACTCTGACTCTTTATTGTTGTAAGAAAAATAGTTCATCATCAGAGAATGGTCAGTTTCCATTCACCCATCTGA
AAGATTTTAAGATGAGGTTGAATTCTAGTTTAGAGTTAGCAGACTACCCAAATCTGGCCCACTGCCAATAAAGTCTCATTGGAACACAGC
CATGCTCATTTGTTTACATGTTGTTTATGGCGACTGCCATGCTGCAAGAGCAGAATTGAGTAGTTGTGATAGAGACCTATGGCCTGCAAA
GCCTAATTAATATGTAGCCCTTTCAGAAAAGGTTTGCCTGCCCCTGTCCTAGTGCAAAGTGAATTTAGAGTGAGCCAGATTATGGAGGAT
TCTGTGACTCTTGCCAAATAATTTTGACTTCATCCTGTAGGTATTAAGTCATTAAGGCGTTTTAAATCATACAGTCAGGTTTGTATTTCT
GAGCTGTCTATAATGAATGATATAGAAGGTGGTTTCGAAGGAGGAGACTCCAGACAAGGAAAACAGAAATCTTATGTTGCCAAGTTGTCT
TTGCTCTTAGGTGGGTTATCCTGGAGAAAATGGACTCAGGAGCTAATACTGTCTACAGTGGAGCTTGGTGCAATTAGAAGCAAAAGACTG
TACCTAACTGGAATGAGGTTACTTTTTATGGCTTATCAAATGCTTGTCCTGGCCCGATGCAGTGGCTCATGCCTGTAATCCCAGCACTTT
GAGAGGCTGAGGCAGGGCAGATTGCATGAGCCCAGGAGTTCGAGACCAACTTGGGCAACATGGTGAAACACTGTCTCTACATAAAATACA
AAAATTAGCTGGGCGTGGTGGCACGTTCCTGCAATCCCAGCTACTCATAAGGCTGAGGTGGGAGGATCTATTGAGCCCTGGAATTCGAGG
ATGCAATTAATTGTGGTTGTGTCACAGTTCACTGCAGCCTGGGTGACACTCCAGCCTGGGTGACAAAGGAGACCCCGTCAAAAAAAAAAG
TACTTGTCCCAAAAGTTTTTGTTTCCTAGCTTAGAATTTATAATCAGATTAGGTTTTGGAGATAAAGTATATGTGGTATTTTTTTTTTTT
TTTTTGAGACGACAGTCTTGCTCTGTCATCAGGCTGGAGTGCAGTGGCGCAATTTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGC
AATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCATGCCACGACGCCCAGCTGATTTTTGTGTTTTTAGTAGAGACGGGG
TTTCACCATGTTGGCCAAGATGGTCTCAATCTCTTGACCTTGTGATCCACCTGCCTTGGCCTTCCAAAGTGTTGGAATTACAGGCGTGAG
CCACCGCGCCTGGTCTATATGTGATTTCAAATTAGGTGGCCTTATAAATATAAGCAGATGGTTTCTGGGCAAAATCAAATGATTTCTGTC

>In-frame_ENST00000535943_ENST00000527806_TCGA-EO-A1Y5-01A_INTS4_chr11_77594878_-_NDUFC2_chr11_77784187_length(amino acids)=312AA_start in transcript=138_stop in transcript=1076
MPALKQTASQVTQTLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVE
NKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQ
SAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for INTS4-NDUFC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for INTS4-NDUFC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for INTS4-NDUFC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneINTS4C0033578Prostatic Neoplasms1CTD_human
HgeneINTS4C0376358Malignant neoplasm of prostate1CTD_human