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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IP6K2-GNB3 (FusionGDB2 ID:39848)

Fusion Gene Summary for IP6K2-GNB3

check button Fusion gene summary
Fusion gene informationFusion gene name: IP6K2-GNB3
Fusion gene ID: 39848
HgeneTgene
Gene symbol

IP6K2

GNB3

Gene ID

51447

2784

Gene nameinositol hexakisphosphate kinase 2G protein subunit beta 3
SynonymsIHPK2|InsP6K2|PIUSCSNB1H
Cytomap

3p21.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptioninositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulatorguanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3G protein, beta-3 subunitGTP-binding regulatory protein beta-3 chainguanine nucleotide binding protein (G protein), beta polypeptide 3guanine nucleotide-binding protein G(I)/G(S)/G(T) bet
Modification date2020032720200313
UniProtAcc

Q9UHH9

P16520

Ensembl transtripts involved in fusion geneENST00000328631, ENST00000340879, 
ENST00000432678, ENST00000431721, 
ENST00000449610, ENST00000413298, 
ENST00000450045, ENST00000446860, 
ENST00000417896, ENST00000443964, 
ENST00000436134, ENST00000453202, 
ENST00000229264, ENST00000435982, 
Fusion gene scores* DoF score13 X 12 X 7=10924 X 5 X 3=60
# samples 205
** MAII scorelog2(20/1092*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IP6K2 [Title/Abstract] AND GNB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIP6K2(48732522)-GNB3(6952940), # samples:1
IP6K2(48732523)-GNB3(6952941), # samples:1
Anticipated loss of major functional domain due to fusion event.IP6K2-GNB3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IP6K2-GNB3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
IP6K2-GNB3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIP6K2

GO:0043647

inositol phosphate metabolic process

30624931

HgeneIP6K2

GO:0046854

phosphatidylinositol phosphorylation

10574768


check buttonFusion gene breakpoints across IP6K2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GNB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-7808IP6K2chr3

48732522

-GNB3chr12

6952940

+
ChimerDB4STADTCGA-IN-7808-01AIP6K2chr3

48732523

-GNB3chr12

6952941

+


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Fusion Gene ORF analysis for IP6K2-GNB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000328631ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000328631ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000340879ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000340879ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000432678ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000432678ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000431721ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000431721ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000449610ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000449610ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
In-frameENST00000413298ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
In-frameENST00000413298ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000450045ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000450045ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000446860ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000446860ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000417896ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000417896ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000443964ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000443964ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
5UTR-3CDSENST00000436134ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
5UTR-3CDSENST00000436134ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000453202ENST00000229264IP6K2chr3

48732522

-GNB3chr12

6952940

+
intron-3CDSENST00000453202ENST00000435982IP6K2chr3

48732522

-GNB3chr12

6952940

+
Frame-shiftENST00000328631ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000328631ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000340879ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000340879ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000432678ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000432678ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000431721ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000431721ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000449610ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000449610ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
In-frameENST00000413298ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
In-frameENST00000413298ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000450045ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
Frame-shiftENST00000450045ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000446860ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000446860ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000417896ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000417896ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000443964ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000443964ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
5UTR-3CDSENST00000436134ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
5UTR-3CDSENST00000436134ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000453202ENST00000229264IP6K2chr3

48732523

-GNB3chr12

6952941

+
intron-3CDSENST00000453202ENST00000435982IP6K2chr3

48732523

-GNB3chr12

6952941

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413298IP6K2chr348732522-ENST00000229264GNB3chr126952940+15255045081029173
ENST00000413298IP6K2chr348732522-ENST00000435982GNB3chr126952940+10305045081029174
ENST00000413298IP6K2chr348732523-ENST00000229264GNB3chr126952941+15255045081029173
ENST00000413298IP6K2chr348732523-ENST00000435982GNB3chr126952941+10305045081029174

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413298ENST00000229264IP6K2chr348732522-GNB3chr126952940+0.0169479530.983052
ENST00000413298ENST00000435982IP6K2chr348732522-GNB3chr126952940+0.0189599170.9810401
ENST00000413298ENST00000229264IP6K2chr348732523-GNB3chr126952941+0.0169479530.983052
ENST00000413298ENST00000435982IP6K2chr348732523-GNB3chr126952941+0.0189599170.9810401

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Fusion Genomic Features for IP6K2-GNB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IP6K2chr348732522-GNB3chr126952940+0.0532311720.9467689
IP6K2chr348732522-GNB3chr126952940+0.0532311720.9467689
IP6K2chr348732522-GNB3chr126952940+0.0532311720.9467689
IP6K2chr348732522-GNB3chr126952940+0.0532311720.9467689

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IP6K2-GNB3


check button Go to

FGviewer for the breakpoints of chr3:48732522-chr12:6952940

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IP6K2

Q9UHH9

GNB3

P16520

FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:30624931}.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNB3chr3:48732522chr12:6952940ENST00000229264711182_212165.66666666666666341.0RepeatNote=WD 4
TgeneGNB3chr3:48732522chr12:6952940ENST00000229264711224_254165.66666666666666341.0RepeatNote=WD 5
TgeneGNB3chr3:48732522chr12:6952940ENST00000229264711268_298165.66666666666666341.0RepeatNote=WD 6
TgeneGNB3chr3:48732522chr12:6952940ENST00000229264711310_340165.66666666666666341.0RepeatNote=WD 7
TgeneGNB3chr3:48732523chr12:6952941ENST00000229264711182_212165.66666666666666341.0RepeatNote=WD 4
TgeneGNB3chr3:48732523chr12:6952941ENST00000229264711224_254165.66666666666666341.0RepeatNote=WD 5
TgeneGNB3chr3:48732523chr12:6952941ENST00000229264711268_298165.66666666666666341.0RepeatNote=WD 6
TgeneGNB3chr3:48732523chr12:6952941ENST00000229264711310_340165.66666666666666341.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIP6K2chr3:48732522chr12:6952940ENST00000328631-26207_20967.33333333333333427.0Nucleotide bindingATP
HgeneIP6K2chr3:48732522chr12:6952940ENST00000340879-23207_20967.3333333333333398.0Nucleotide bindingATP
HgeneIP6K2chr3:48732522chr12:6952940ENST00000413298-34207_20967.3333333333333398.0Nucleotide bindingATP
HgeneIP6K2chr3:48732522chr12:6952940ENST00000431721-13207_2090186.0Nucleotide bindingATP
HgeneIP6K2chr3:48732522chr12:6952940ENST00000432678-24207_20967.33333333333333221.66666666666666Nucleotide bindingATP
HgeneIP6K2chr3:48732522chr12:6952940ENST00000446860-13207_2090189.0Nucleotide bindingATP
HgeneIP6K2chr3:48732523chr12:6952941ENST00000328631-26207_20967.33333333333333427.0Nucleotide bindingATP
HgeneIP6K2chr3:48732523chr12:6952941ENST00000340879-23207_20967.3333333333333398.0Nucleotide bindingATP
HgeneIP6K2chr3:48732523chr12:6952941ENST00000413298-34207_20967.3333333333333398.0Nucleotide bindingATP
HgeneIP6K2chr3:48732523chr12:6952941ENST00000431721-13207_2090186.0Nucleotide bindingATP
HgeneIP6K2chr3:48732523chr12:6952941ENST00000432678-24207_20967.33333333333333221.66666666666666Nucleotide bindingATP
HgeneIP6K2chr3:48732523chr12:6952941ENST00000446860-13207_2090189.0Nucleotide bindingATP
HgeneIP6K2chr3:48732522chr12:6952940ENST00000328631-26236_24367.33333333333333427.0RegionSubstrate binding
HgeneIP6K2chr3:48732522chr12:6952940ENST00000340879-23236_24367.3333333333333398.0RegionSubstrate binding
HgeneIP6K2chr3:48732522chr12:6952940ENST00000413298-34236_24367.3333333333333398.0RegionSubstrate binding
HgeneIP6K2chr3:48732522chr12:6952940ENST00000431721-13236_2430186.0RegionSubstrate binding
HgeneIP6K2chr3:48732522chr12:6952940ENST00000432678-24236_24367.33333333333333221.66666666666666RegionSubstrate binding
HgeneIP6K2chr3:48732522chr12:6952940ENST00000446860-13236_2430189.0RegionSubstrate binding
HgeneIP6K2chr3:48732523chr12:6952941ENST00000328631-26236_24367.33333333333333427.0RegionSubstrate binding
HgeneIP6K2chr3:48732523chr12:6952941ENST00000340879-23236_24367.3333333333333398.0RegionSubstrate binding
HgeneIP6K2chr3:48732523chr12:6952941ENST00000413298-34236_24367.3333333333333398.0RegionSubstrate binding
HgeneIP6K2chr3:48732523chr12:6952941ENST00000431721-13236_2430186.0RegionSubstrate binding
HgeneIP6K2chr3:48732523chr12:6952941ENST00000432678-24236_24367.33333333333333221.66666666666666RegionSubstrate binding
HgeneIP6K2chr3:48732523chr12:6952941ENST00000446860-13236_2430189.0RegionSubstrate binding
TgeneGNB3chr3:48732522chr12:6952940ENST00000229264711141_170165.66666666666666341.0RepeatNote=WD 3
TgeneGNB3chr3:48732522chr12:6952940ENST0000022926471153_83165.66666666666666341.0RepeatNote=WD 1
TgeneGNB3chr3:48732522chr12:6952940ENST0000022926471195_125165.66666666666666341.0RepeatNote=WD 2
TgeneGNB3chr3:48732523chr12:6952941ENST00000229264711141_170165.66666666666666341.0RepeatNote=WD 3
TgeneGNB3chr3:48732523chr12:6952941ENST0000022926471153_83165.66666666666666341.0RepeatNote=WD 1
TgeneGNB3chr3:48732523chr12:6952941ENST0000022926471195_125165.66666666666666341.0RepeatNote=WD 2


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Fusion Gene Sequence for IP6K2-GNB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000413298_ENST00000229264_TCGA-IN-7808_IP6K2_chr3_48732522_-_GNB3_chr12_6952940_length(transcript)=1525nt_BP=504nt
GGTGCGAGAGAAACAATAGGACGGAAACGCCGAGGAACCCGGCTGAGGCGGCAGGGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTCAT
GTGATCACGGCTCACTGCAGCCTTGACCTCCCAGGCTCCAGTGACCCTTCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGCAGAGCAT
CCTGGCCAGAACAAGCCAAGGAGCCAAGACGAGAGGGACACACGGACAAACAACAGACAGAAGACGTACTGGCCGCTGGACTCCGCTGCC
TCCCCCATCTCCCCGCCATCTGCGCCCGGAGGATGAGCCCAGCCTTCAGGGCCATGGATGTGGAGCCCCGCGCCAAAGGCGTCCTTCTGG
AGCCCTTTGTCCACCAGGTCGGGGGGCACTCATGCGTGCTCCGCTTCAATGAGACAACCCTGTGCAAGCCCCTGGTCCCAAGGGAACATC
AGTTCTACGAGACCCTCCCTGCTGAGATGCGCAAATTCACTCCCCAGTACAAAGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGAC
TGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGC
CAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGG
AGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAG
CATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGA
CTCCATGAAGTCTGAGCGTGTGGGCATCCTCTCTGGCCACGATAACAGGGTGAGCTGCCTGGGAGTCACAGCTGACGGGATGGCTGTGGC
CACAGGTTCCTGGGACAGCTTCCTCAAAATCTGGAACTGAGGAGGCTGGAGAAAGGGAAGTGGAAGGCAGTGAACACACTCAGCAGCCCC
CTGCCCGACCCCATCTCATTCAGGTGTTCTCTTCTATATTCCGGGTGCCATTCCCACTAAGCTTTCTCCTTTGAGGGCAGTGGGGAGCAT
GGGACTGTGCCTTTGGGAGGCAGCATCAGGGACACAGGGGCAAAGAACTGCCCCATCTCCTCCCATGGCCTTCCCTCCCCACAGTCCTCA
CAGCCTCTCCCTTAATGAGCAAGGACAACCTGCCCCTCCCCAGCCCTTTGCAGGCCCAGCAGACTTGAGTCTGAGGCCCCAGGCCCTAGG
ATTCCTCCCCCAGAGCCACTACCTTTGTCCAGGCCTGGGTGGTATAGGGCGTTTGGCCCTGTGACTATGGCTCTGGCACCACTAGGGTCC

>In-frame_ENST00000413298_ENST00000229264_TCGA-IN-7808_IP6K2_chr3_48732522_-_GNB3_chr12_6952940_length(amino acids)=173AA_start in transcript=508_stop in transcript=1029
MWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA

--------------------------------------------------------------
>In-frame_ENST00000413298_ENST00000435982_TCGA-IN-7808_IP6K2_chr3_48732522_-_GNB3_chr12_6952940_length(transcript)=1030nt_BP=504nt
GGTGCGAGAGAAACAATAGGACGGAAACGCCGAGGAACCCGGCTGAGGCGGCAGGGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTCAT
GTGATCACGGCTCACTGCAGCCTTGACCTCCCAGGCTCCAGTGACCCTTCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGCAGAGCAT
CCTGGCCAGAACAAGCCAAGGAGCCAAGACGAGAGGGACACACGGACAAACAACAGACAGAAGACGTACTGGCCGCTGGACTCCGCTGCC
TCCCCCATCTCCCCGCCATCTGCGCCCGGAGGATGAGCCCAGCCTTCAGGGCCATGGATGTGGAGCCCCGCGCCAAAGGCGTCCTTCTGG
AGCCCTTTGTCCACCAGGTCGGGGGGCACTCATGCGTGCTCCGCTTCAATGAGACAACCCTGTGCAAGCCCCTGGTCCCAAGGGAACATC
AGTTCTACGAGACCCTCCCTGCTGAGATGCGCAAATTCACTCCCCAGTACAAAGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGAC
TGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGC
CAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGG
AGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAG
CATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGA
CTCCATGAAGTCTGAGCGTGTGGGCATCCTCTCTGGCCACGATAACAGGGTGAGCTGCCTGGGAGTCACAGCTGACGGGATGGCTGTGGC

>In-frame_ENST00000413298_ENST00000435982_TCGA-IN-7808_IP6K2_chr3_48732522_-_GNB3_chr12_6952940_length(amino acids)=174AA_start in transcript=508_stop in transcript=1029
MWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA

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>In-frame_ENST00000413298_ENST00000229264_TCGA-IN-7808-01A_IP6K2_chr3_48732523_-_GNB3_chr12_6952941_length(transcript)=1525nt_BP=504nt
GGTGCGAGAGAAACAATAGGACGGAAACGCCGAGGAACCCGGCTGAGGCGGCAGGGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTCAT
GTGATCACGGCTCACTGCAGCCTTGACCTCCCAGGCTCCAGTGACCCTTCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGCAGAGCAT
CCTGGCCAGAACAAGCCAAGGAGCCAAGACGAGAGGGACACACGGACAAACAACAGACAGAAGACGTACTGGCCGCTGGACTCCGCTGCC
TCCCCCATCTCCCCGCCATCTGCGCCCGGAGGATGAGCCCAGCCTTCAGGGCCATGGATGTGGAGCCCCGCGCCAAAGGCGTCCTTCTGG
AGCCCTTTGTCCACCAGGTCGGGGGGCACTCATGCGTGCTCCGCTTCAATGAGACAACCCTGTGCAAGCCCCTGGTCCCAAGGGAACATC
AGTTCTACGAGACCCTCCCTGCTGAGATGCGCAAATTCACTCCCCAGTACAAAGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGAC
TGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGC
CAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGG
AGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAG
CATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGA
CTCCATGAAGTCTGAGCGTGTGGGCATCCTCTCTGGCCACGATAACAGGGTGAGCTGCCTGGGAGTCACAGCTGACGGGATGGCTGTGGC
CACAGGTTCCTGGGACAGCTTCCTCAAAATCTGGAACTGAGGAGGCTGGAGAAAGGGAAGTGGAAGGCAGTGAACACACTCAGCAGCCCC
CTGCCCGACCCCATCTCATTCAGGTGTTCTCTTCTATATTCCGGGTGCCATTCCCACTAAGCTTTCTCCTTTGAGGGCAGTGGGGAGCAT
GGGACTGTGCCTTTGGGAGGCAGCATCAGGGACACAGGGGCAAAGAACTGCCCCATCTCCTCCCATGGCCTTCCCTCCCCACAGTCCTCA
CAGCCTCTCCCTTAATGAGCAAGGACAACCTGCCCCTCCCCAGCCCTTTGCAGGCCCAGCAGACTTGAGTCTGAGGCCCCAGGCCCTAGG
ATTCCTCCCCCAGAGCCACTACCTTTGTCCAGGCCTGGGTGGTATAGGGCGTTTGGCCCTGTGACTATGGCTCTGGCACCACTAGGGTCC

>In-frame_ENST00000413298_ENST00000229264_TCGA-IN-7808-01A_IP6K2_chr3_48732523_-_GNB3_chr12_6952941_length(amino acids)=173AA_start in transcript=508_stop in transcript=1029
MWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA

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>In-frame_ENST00000413298_ENST00000435982_TCGA-IN-7808-01A_IP6K2_chr3_48732523_-_GNB3_chr12_6952941_length(transcript)=1030nt_BP=504nt
GGTGCGAGAGAAACAATAGGACGGAAACGCCGAGGAACCCGGCTGAGGCGGCAGGGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTCAT
GTGATCACGGCTCACTGCAGCCTTGACCTCCCAGGCTCCAGTGACCCTTCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGCAGAGCAT
CCTGGCCAGAACAAGCCAAGGAGCCAAGACGAGAGGGACACACGGACAAACAACAGACAGAAGACGTACTGGCCGCTGGACTCCGCTGCC
TCCCCCATCTCCCCGCCATCTGCGCCCGGAGGATGAGCCCAGCCTTCAGGGCCATGGATGTGGAGCCCCGCGCCAAAGGCGTCCTTCTGG
AGCCCTTTGTCCACCAGGTCGGGGGGCACTCATGCGTGCTCCGCTTCAATGAGACAACCCTGTGCAAGCCCCTGGTCCCAAGGGAACATC
AGTTCTACGAGACCCTCCCTGCTGAGATGCGCAAATTCACTCCCCAGTACAAAGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGAC
TGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGC
CAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGG
AGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAG
CATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGA
CTCCATGAAGTCTGAGCGTGTGGGCATCCTCTCTGGCCACGATAACAGGGTGAGCTGCCTGGGAGTCACAGCTGACGGGATGGCTGTGGC

>In-frame_ENST00000413298_ENST00000435982_TCGA-IN-7808-01A_IP6K2_chr3_48732523_-_GNB3_chr12_6952941_length(amino acids)=174AA_start in transcript=508_stop in transcript=1029
MWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA

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Fusion Gene PPI Analysis for IP6K2-GNB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IP6K2-GNB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IP6K2-GNB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIP6K2C0020179Huntington Disease1CTD_human
HgeneIP6K2C0393574Huntington Disease, Late Onset1CTD_human
HgeneIP6K2C0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
HgeneIP6K2C0751208Juvenile Huntington Disease1CTD_human
TgeneGNB3C0011570Mental Depression5PSYGENET
TgeneGNB3C0011581Depressive disorder5PSYGENET
TgeneGNB3C0041696Unipolar Depression5PSYGENET
TgeneGNB3C1269683Major Depressive Disorder5PSYGENET
TgeneGNB3C0020538Hypertensive disease2CTD_human
TgeneGNB3C0028754Obesity2CTD_human
TgeneGNB3C0525045Mood Disorders2PSYGENET
TgeneGNB3C0005586Bipolar Disorder1PSYGENET
TgeneGNB3C0010054Coronary Arteriosclerosis1CTD_human
TgeneGNB3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneGNB3C0022333Jacksonian Seizure1CTD_human
TgeneGNB3C0036341Schizophrenia1PSYGENET
TgeneGNB3C0036572Seizures1CTD_human
TgeneGNB3C0043094Weight Gain1CTD_human
TgeneGNB3C0149958Complex partial seizures1CTD_human
TgeneGNB3C0234533Generalized seizures1CTD_human
TgeneGNB3C0234535Clonic Seizures1CTD_human
TgeneGNB3C0270824Visual seizure1CTD_human
TgeneGNB3C0270844Tonic Seizures1CTD_human
TgeneGNB3C0270846Epileptic drop attack1CTD_human
TgeneGNB3C0339535Night blindness, congenital stationary1CTD_human;ORPHANET
TgeneGNB3C0422850Seizures, Somatosensory1CTD_human
TgeneGNB3C0422852Seizures, Auditory1CTD_human
TgeneGNB3C0422853Olfactory seizure1CTD_human
TgeneGNB3C0422854Gustatory seizure1CTD_human
TgeneGNB3C0422855Vertiginous seizure1CTD_human
TgeneGNB3C0494475Tonic - clonic seizures1CTD_human
TgeneGNB3C0751056Non-epileptic convulsion1CTD_human
TgeneGNB3C0751110Single Seizure1CTD_human
TgeneGNB3C0751123Atonic Absence Seizures1CTD_human
TgeneGNB3C0751494Convulsive Seizures1CTD_human
TgeneGNB3C0751495Seizures, Focal1CTD_human
TgeneGNB3C0751496Seizures, Sensory1CTD_human
TgeneGNB3C1956346Coronary Artery Disease1CTD_human
TgeneGNB3C3495874Nonepileptic Seizures1CTD_human
TgeneGNB3C4048158Convulsions1CTD_human
TgeneGNB3C4310758NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1H1UNIPROT
TgeneGNB3C4316903Absence Seizures1CTD_human
TgeneGNB3C4317109Epileptic Seizures1CTD_human
TgeneGNB3C4317123Myoclonic Seizures1CTD_human
TgeneGNB3C4505436Generalized Absence Seizures1CTD_human