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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IPO7-WEE1 (FusionGDB2 ID:39898)

Fusion Gene Summary for IPO7-WEE1

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO7-WEE1
Fusion gene ID: 39898
HgeneTgene
Gene symbol

IPO7

WEE1

Gene ID

10527

7465

Gene nameimportin 7WEE1 G2 checkpoint kinase
SynonymsImp7|RANBP7WEE1A|WEE1hu
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionimportin-7RAN-binding protein 7wee1-like protein kinaseWEE1 homologWEE1+ homologwee1A kinase
Modification date2020031320200313
UniProtAcc

O95373

WEE1

Ensembl transtripts involved in fusion geneENST00000379719, ENST00000533680, 
ENST00000450114, ENST00000299613, 
Fusion gene scores* DoF score14 X 10 X 11=15405 X 7 X 6=210
# samples 178
** MAII scorelog2(17/1540*10)=-3.17932369944456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO7 [Title/Abstract] AND WEE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIPO7(9406394)-WEE1(9597435), # samples:1
IPO7(9406394)-WEE1(9597434), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IPO7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WEE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-4593-01AIPO7chr11

9406394

+WEE1chr11

9597435

+
ChimerDB4LUSCTCGA-22-4593IPO7chr11

9406394

+WEE1chr11

9597434

+


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Fusion Gene ORF analysis for IPO7-WEE1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379719ENST00000450114IPO7chr11

9406394

+WEE1chr11

9597435

+
5CDS-5UTRENST00000379719ENST00000299613IPO7chr11

9406394

+WEE1chr11

9597435

+
intron-3CDSENST00000533680ENST00000450114IPO7chr11

9406394

+WEE1chr11

9597435

+
intron-5UTRENST00000533680ENST00000299613IPO7chr11

9406394

+WEE1chr11

9597435

+
In-frameENST00000379719ENST00000450114IPO7chr11

9406394

+WEE1chr11

9597434

+
5CDS-5UTRENST00000379719ENST00000299613IPO7chr11

9406394

+WEE1chr11

9597434

+
intron-3CDSENST00000533680ENST00000450114IPO7chr11

9406394

+WEE1chr11

9597434

+
intron-5UTRENST00000533680ENST00000299613IPO7chr11

9406394

+WEE1chr11

9597434

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379719IPO7chr119406394+ENST00000450114WEE1chr119597435+21962261421590482
ENST00000379719IPO7chr119406394+ENST00000450114WEE1chr119597434+21962261421590482

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379719ENST00000450114IPO7chr119406394+WEE1chr119597435+0.0008568370.9991431
ENST00000379719ENST00000450114IPO7chr119406394+WEE1chr119597434+0.0008568370.9991431

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Fusion Genomic Features for IPO7-WEE1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IPO7chr119406394+WEE1chr119597434+5.33E-070.9999995
IPO7chr119406394+WEE1chr119597434+5.33E-070.9999995
IPO7chr119406394+WEE1chr119597434+5.33E-070.9999995
IPO7chr119406394+WEE1chr119597434+5.33E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IPO7-WEE1


check button Go to

FGviewer for the breakpoints of chr11:9406394-chr11:9597435

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO7

O95373

WEE1

WEE1

FUNCTION: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}.646

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWEE1chr11:9406394chr11:9597434ENST0000029961301134_430433.0Compositional biasNote=Poly-Glu
TgeneWEE1chr11:9406394chr11:9597434ENST000002996130119_120433.0Compositional biasNote=Poly-Pro
TgeneWEE1chr11:9406394chr11:9597435ENST0000029961301134_430433.0Compositional biasNote=Poly-Glu
TgeneWEE1chr11:9406394chr11:9597435ENST000002996130119_120433.0Compositional biasNote=Poly-Pro
TgeneWEE1chr11:9406394chr11:9597434ENST00000299613011299_5690433.0DomainProtein kinase
TgeneWEE1chr11:9406394chr11:9597434ENST00000450114011299_569192.0647.0DomainProtein kinase
TgeneWEE1chr11:9406394chr11:9597435ENST00000299613011299_5690433.0DomainProtein kinase
TgeneWEE1chr11:9406394chr11:9597435ENST00000450114011299_569192.0647.0DomainProtein kinase
TgeneWEE1chr11:9406394chr11:9597434ENST00000299613011305_3130433.0Nucleotide bindingATP
TgeneWEE1chr11:9406394chr11:9597434ENST00000450114011305_313192.0647.0Nucleotide bindingATP
TgeneWEE1chr11:9406394chr11:9597435ENST00000299613011305_3130433.0Nucleotide bindingATP
TgeneWEE1chr11:9406394chr11:9597435ENST00000450114011305_313192.0647.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPO7chr11:9406394chr11:9597434ENST00000379719+125885_95728.01039.0Compositional biasNote=Asp-rich
HgeneIPO7chr11:9406394chr11:9597435ENST00000379719+125885_95728.01039.0Compositional biasNote=Asp-rich
HgeneIPO7chr11:9406394chr11:9597434ENST00000379719+12522_10128.01039.0DomainImportin N-terminal
HgeneIPO7chr11:9406394chr11:9597435ENST00000379719+12522_10128.01039.0DomainImportin N-terminal
TgeneWEE1chr11:9406394chr11:9597434ENST0000045011401134_43192.0647.0Compositional biasNote=Poly-Glu
TgeneWEE1chr11:9406394chr11:9597434ENST000004501140119_12192.0647.0Compositional biasNote=Poly-Pro
TgeneWEE1chr11:9406394chr11:9597435ENST0000045011401134_43192.0647.0Compositional biasNote=Poly-Glu
TgeneWEE1chr11:9406394chr11:9597435ENST000004501140119_12192.0647.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for IPO7-WEE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000379719_ENST00000450114_TCGA-22-4593-01A_IPO7_chr11_9406394_+_WEE1_chr11_9597435_length(transcript)=2196nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAA
ACTCCGGGGTAGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCC
TTTTACTCCGGATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACAT
GGAAGCCAGTGATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAAC
AGAATTTCATGAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCAT
TAAGCGATCAAAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTC
TCATGTAGTTCGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGC
TATAAGTGAAAACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATAT
TCATTCAATGTCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGG
AGACGAAGATGATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGA
GGGCGATAGTCGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGT
GGTATGTGCTGCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGT
GCTTTCCCAAGAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTC
AGTATTGCTGTCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAAAGA
ACTCAAGAAAGCACAGATGGCAAAAGCTGCAGCTGAGGAAAGAGCACTCTTCACTGACCGGATGGCCACTAGGTCCACCACCCAGAGTAA
TAGAACATCTCGACTTATTGGAAAGAAAATGAACCGCTCTGTCAGCCTTACTATATACTGAGCTACTCCTTTCCCACCTCCCCCTGAACA
CTGTGACAAGAGGAAGCTAGGTTGAAATCACTGATAGAATCCAGTTTGCAATTACTTTCTCGATTGGTGTCAGTAGTTTTACTGATTAGG
ACTTTTATTGTGAATTACAGTTGAAAGCTGTATTTTGATGATTGCTATGTCAGGCTTTCATCTAATCTTACCAGTCTGTCTTCTGTAGGA
TGTGTCACTGTTGGATGTTACACCAGCCTTTCCAGGGTTAACCACTGTGGTGGTGTGCTGCTTATAGTTTGCTGTTGCATTGTAATAAAA
GGTGTCTTTCCCTGTAGTGACCTGTAAAAAGTACTCAAGGGCTTTATTACAGACATACCCTCCCTTTGAAAAGGGACATGCTAAAAGACT
CATTACTACTCAGCCTTCAATGTACCTGTGTGTCCATCTTATATTTCTTTTTTTTTTAATTGTGAATTAGACTTGTATATCCCACTGGGA
GCACTTTGTAGGCATTGCATGAACCATGGGATGATGATTCTGTGGAGGTATTGCCTTGTGAATTTGCTGCTATTTTAGTTTTGTCTTTGC

>In-frame_ENST00000379719_ENST00000450114_TCGA-22-4593-01A_IPO7_chr11_9406394_+_WEE1_chr11_9597435_length(amino acids)=482AA_start in transcript=142_stop in transcript=1590
MDPNTIIEALRGTMDPALREAAERQLNESLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRR
KRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNAL
REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI
SRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH
EIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALF

--------------------------------------------------------------
>In-frame_ENST00000379719_ENST00000450114_TCGA-22-4593_IPO7_chr11_9406394_+_WEE1_chr11_9597434_length(transcript)=2196nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAA
ACTCCGGGGTAGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCC
TTTTACTCCGGATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACAT
GGAAGCCAGTGATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAAC
AGAATTTCATGAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCAT
TAAGCGATCAAAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTC
TCATGTAGTTCGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGC
TATAAGTGAAAACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATAT
TCATTCAATGTCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGG
AGACGAAGATGATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGA
GGGCGATAGTCGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGT
GGTATGTGCTGCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGT
GCTTTCCCAAGAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTC
AGTATTGCTGTCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAAAGA
ACTCAAGAAAGCACAGATGGCAAAAGCTGCAGCTGAGGAAAGAGCACTCTTCACTGACCGGATGGCCACTAGGTCCACCACCCAGAGTAA
TAGAACATCTCGACTTATTGGAAAGAAAATGAACCGCTCTGTCAGCCTTACTATATACTGAGCTACTCCTTTCCCACCTCCCCCTGAACA
CTGTGACAAGAGGAAGCTAGGTTGAAATCACTGATAGAATCCAGTTTGCAATTACTTTCTCGATTGGTGTCAGTAGTTTTACTGATTAGG
ACTTTTATTGTGAATTACAGTTGAAAGCTGTATTTTGATGATTGCTATGTCAGGCTTTCATCTAATCTTACCAGTCTGTCTTCTGTAGGA
TGTGTCACTGTTGGATGTTACACCAGCCTTTCCAGGGTTAACCACTGTGGTGGTGTGCTGCTTATAGTTTGCTGTTGCATTGTAATAAAA
GGTGTCTTTCCCTGTAGTGACCTGTAAAAAGTACTCAAGGGCTTTATTACAGACATACCCTCCCTTTGAAAAGGGACATGCTAAAAGACT
CATTACTACTCAGCCTTCAATGTACCTGTGTGTCCATCTTATATTTCTTTTTTTTTTAATTGTGAATTAGACTTGTATATCCCACTGGGA
GCACTTTGTAGGCATTGCATGAACCATGGGATGATGATTCTGTGGAGGTATTGCCTTGTGAATTTGCTGCTATTTTAGTTTTGTCTTTGC

>In-frame_ENST00000379719_ENST00000450114_TCGA-22-4593_IPO7_chr11_9406394_+_WEE1_chr11_9597434_length(amino acids)=482AA_start in transcript=142_stop in transcript=1590
MDPNTIIEALRGTMDPALREAAERQLNESLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRR
KRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNAL
REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI
SRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH
EIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IPO7-WEE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IPO7-WEE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IPO7-WEE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIPO7C0019693HIV Infections1CTD_human
HgeneIPO7C4505456HIV Coinfection1CTD_human
TgeneWEE1C1168401Squamous cell carcinoma of the head and neck1CTD_human