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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IPO7-ZNF143 (FusionGDB2 ID:39899)

Fusion Gene Summary for IPO7-ZNF143

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO7-ZNF143
Fusion gene ID: 39899
HgeneTgene
Gene symbol

IPO7

ZNF143

Gene ID

10527

7702

Gene nameimportin 7zinc finger protein 143
SynonymsImp7|RANBP7SBF|STAF|pHZ-1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionimportin-7RAN-binding protein 7zinc finger protein 143SPH-binding factorhStafselenocysteine tRNA gene transcription-activating factortranscriptional activator Staf
Modification date2020031320200313
UniProtAcc

O95373

.
Ensembl transtripts involved in fusion geneENST00000379719, ENST00000533680, 
ENST00000396604, ENST00000396602, 
ENST00000530463, ENST00000396597, 
ENST00000299606, 
Fusion gene scores* DoF score14 X 10 X 11=154012 X 16 X 8=1536
# samples 1715
** MAII scorelog2(17/1540*10)=-3.17932369944456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1536*10)=-3.35614381022528
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO7 [Title/Abstract] AND ZNF143 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF143(9492967)-IPO7(9462002), # samples:2
IPO7(9406394)-ZNF143(9549076), # samples:1
IPO7(9424918)-ZNF143(9499936), # samples:1
IPO7(9406394)-ZNF143(9549077), # samples:1
Anticipated loss of major functional domain due to fusion event.IPO7-ZNF143 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IPO7-ZNF143 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
IPO7-ZNF143 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF143

GO:0045944

positive regulation of transcription by RNA polymerase II

10893243


check buttonFusion gene breakpoints across IPO7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZNF143 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA56IPO7chr11

9406394

+ZNF143chr11

9549076

+
ChimerDB4STADTCGA-BR-8059IPO7chr11

9424918

+ZNF143chr11

9499936

+
ChimerDB4BLCATCGA-ZF-AA56IPO7chr11

9406394

+ZNF143chr11

9549077

+


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Fusion Gene ORF analysis for IPO7-ZNF143

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379719ENST00000396604IPO7chr11

9406394

+ZNF143chr11

9549076

+
Frame-shiftENST00000379719ENST00000396602IPO7chr11

9406394

+ZNF143chr11

9549076

+
In-frameENST00000379719ENST00000530463IPO7chr11

9406394

+ZNF143chr11

9549076

+
In-frameENST00000379719ENST00000396597IPO7chr11

9406394

+ZNF143chr11

9549076

+
Frame-shiftENST00000379719ENST00000299606IPO7chr11

9406394

+ZNF143chr11

9549076

+
intron-3CDSENST00000533680ENST00000396604IPO7chr11

9406394

+ZNF143chr11

9549076

+
intron-3CDSENST00000533680ENST00000396602IPO7chr11

9406394

+ZNF143chr11

9549076

+
intron-3CDSENST00000533680ENST00000530463IPO7chr11

9406394

+ZNF143chr11

9549076

+
intron-3CDSENST00000533680ENST00000396597IPO7chr11

9406394

+ZNF143chr11

9549076

+
intron-3CDSENST00000533680ENST00000299606IPO7chr11

9406394

+ZNF143chr11

9549076

+
In-frameENST00000379719ENST00000396604IPO7chr11

9424918

+ZNF143chr11

9499936

+
In-frameENST00000379719ENST00000396602IPO7chr11

9424918

+ZNF143chr11

9499936

+
In-frameENST00000379719ENST00000530463IPO7chr11

9424918

+ZNF143chr11

9499936

+
In-frameENST00000379719ENST00000396597IPO7chr11

9424918

+ZNF143chr11

9499936

+
In-frameENST00000379719ENST00000299606IPO7chr11

9424918

+ZNF143chr11

9499936

+
3UTR-3CDSENST00000533680ENST00000396604IPO7chr11

9424918

+ZNF143chr11

9499936

+
3UTR-3CDSENST00000533680ENST00000396602IPO7chr11

9424918

+ZNF143chr11

9499936

+
3UTR-3CDSENST00000533680ENST00000530463IPO7chr11

9424918

+ZNF143chr11

9499936

+
3UTR-3CDSENST00000533680ENST00000396597IPO7chr11

9424918

+ZNF143chr11

9499936

+
3UTR-3CDSENST00000533680ENST00000299606IPO7chr11

9424918

+ZNF143chr11

9499936

+
In-frameENST00000379719ENST00000396604IPO7chr11

9406394

+ZNF143chr11

9549077

+
Frame-shiftENST00000379719ENST00000396602IPO7chr11

9406394

+ZNF143chr11

9549077

+
In-frameENST00000379719ENST00000530463IPO7chr11

9406394

+ZNF143chr11

9549077

+
In-frameENST00000379719ENST00000396597IPO7chr11

9406394

+ZNF143chr11

9549077

+
Frame-shiftENST00000379719ENST00000299606IPO7chr11

9406394

+ZNF143chr11

9549077

+
intron-3CDSENST00000533680ENST00000396604IPO7chr11

9406394

+ZNF143chr11

9549077

+
intron-3CDSENST00000533680ENST00000396602IPO7chr11

9406394

+ZNF143chr11

9549077

+
intron-3CDSENST00000533680ENST00000530463IPO7chr11

9406394

+ZNF143chr11

9549077

+
intron-3CDSENST00000533680ENST00000396597IPO7chr11

9406394

+ZNF143chr11

9549077

+
intron-3CDSENST00000533680ENST00000299606IPO7chr11

9406394

+ZNF143chr11

9549077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379719IPO7chr119406394+ENST00000396604ZNF143chr119549076+751226260385
ENST00000379719IPO7chr119406394+ENST00000530463ZNF143chr119549076+3102262828864
ENST00000379719IPO7chr119406394+ENST00000396597ZNF143chr119549076+3432262828864
ENST00000379719IPO7chr119406394+ENST00000396604ZNF143chr119549077+751226260385
ENST00000379719IPO7chr119406394+ENST00000530463ZNF143chr119549077+3102262828864
ENST00000379719IPO7chr119406394+ENST00000396597ZNF143chr119549077+3432262828864

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379719ENST00000396604IPO7chr119406394+ZNF143chr119549076+0.745163740.25483623
ENST00000379719ENST00000530463IPO7chr119406394+ZNF143chr119549076+0.0880912240.9119088
ENST00000379719ENST00000396597IPO7chr119406394+ZNF143chr119549076+0.0741995950.9258004
ENST00000379719ENST00000396604IPO7chr119406394+ZNF143chr119549077+0.745163740.25483623
ENST00000379719ENST00000530463IPO7chr119406394+ZNF143chr119549077+0.0880912240.9119088
ENST00000379719ENST00000396597IPO7chr119406394+ZNF143chr119549077+0.0741995950.9258004

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Fusion Genomic Features for IPO7-ZNF143


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IPO7chr119406394+ZNF143chr119549076+5.33E-131
IPO7chr119424918+ZNF143chr119499936+3.16E-121
IPO7chr119406394+ZNF143chr119549076+5.33E-131
IPO7chr119424918+ZNF143chr119499936+3.16E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IPO7-ZNF143


check button Go to

FGviewer for the breakpoints of chr11:9406394-chr11:9549076

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO7

O95373

.
FUNCTION: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315237_26193.33333333333333608.0Zinc fingerC2H2-type 1
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315267_29193.33333333333333608.0Zinc fingerC2H2-type 2
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315297_32193.33333333333333608.0Zinc fingerC2H2-type 3
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315327_35193.33333333333333608.0Zinc fingerC2H2-type 4
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315357_38193.33333333333333608.0Zinc fingerC2H2-type 5
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315387_41193.33333333333333608.0Zinc fingerC2H2-type 6
TgeneZNF143chr11:9424918chr11:9499936ENST00000396597315417_44093.33333333333333608.0Zinc fingerC2H2-type 7
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416237_261124.33333333333333639.0Zinc fingerC2H2-type 1
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416267_291124.33333333333333639.0Zinc fingerC2H2-type 2
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416297_321124.33333333333333639.0Zinc fingerC2H2-type 3
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416327_351124.33333333333333639.0Zinc fingerC2H2-type 4
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416357_381124.33333333333333639.0Zinc fingerC2H2-type 5
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416387_411124.33333333333333639.0Zinc fingerC2H2-type 6
TgeneZNF143chr11:9424918chr11:9499936ENST00000396602416417_440124.33333333333333639.0Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIPO7chr11:9406394chr11:9549076ENST00000379719+125885_95728.01039.0Compositional biasNote=Asp-rich
HgeneIPO7chr11:9406394chr11:9549077ENST00000379719+125885_95728.01039.0Compositional biasNote=Asp-rich
HgeneIPO7chr11:9424918chr11:9499936ENST00000379719+225885_95755.3333333333333361039.0Compositional biasNote=Asp-rich
HgeneIPO7chr11:9406394chr11:9549076ENST00000379719+12522_10128.01039.0DomainImportin N-terminal
HgeneIPO7chr11:9406394chr11:9549077ENST00000379719+12522_10128.01039.0DomainImportin N-terminal
HgeneIPO7chr11:9424918chr11:9499936ENST00000379719+22522_10155.3333333333333361039.0DomainImportin N-terminal
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315237_261580.0608.0Zinc fingerC2H2-type 1
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315267_291580.0608.0Zinc fingerC2H2-type 2
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315297_321580.0608.0Zinc fingerC2H2-type 3
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315327_351580.0608.0Zinc fingerC2H2-type 4
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315357_381580.0608.0Zinc fingerC2H2-type 5
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315387_411580.0608.0Zinc fingerC2H2-type 6
TgeneZNF143chr11:9406394chr11:9549076ENST000003965971315417_440580.0608.0Zinc fingerC2H2-type 7
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416237_261611.0639.0Zinc fingerC2H2-type 1
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416267_291611.0639.0Zinc fingerC2H2-type 2
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416297_321611.0639.0Zinc fingerC2H2-type 3
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416327_351611.0639.0Zinc fingerC2H2-type 4
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416357_381611.0639.0Zinc fingerC2H2-type 5
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416387_411611.0639.0Zinc fingerC2H2-type 6
TgeneZNF143chr11:9406394chr11:9549076ENST000003966021416417_440611.0639.0Zinc fingerC2H2-type 7
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315237_261580.0608.0Zinc fingerC2H2-type 1
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315267_291580.0608.0Zinc fingerC2H2-type 2
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315297_321580.0608.0Zinc fingerC2H2-type 3
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315327_351580.0608.0Zinc fingerC2H2-type 4
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315357_381580.0608.0Zinc fingerC2H2-type 5
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315387_411580.0608.0Zinc fingerC2H2-type 6
TgeneZNF143chr11:9406394chr11:9549077ENST000003965971315417_440580.0608.0Zinc fingerC2H2-type 7
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416237_261611.0639.0Zinc fingerC2H2-type 1
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416267_291611.0639.0Zinc fingerC2H2-type 2
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416297_321611.0639.0Zinc fingerC2H2-type 3
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416327_351611.0639.0Zinc fingerC2H2-type 4
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416357_381611.0639.0Zinc fingerC2H2-type 5
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416387_411611.0639.0Zinc fingerC2H2-type 6
TgeneZNF143chr11:9406394chr11:9549077ENST000003966021416417_440611.0639.0Zinc fingerC2H2-type 7


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Fusion Gene Sequence for IPO7-ZNF143


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000379719_ENST00000396604_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549076_length(transcript)=751nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAACTTGGAGAACAGCCATCTCTGGAAGAAGCCATCAGAATAGCGTC
TAGAATCCAACAAGGAGAAACGCCAGGGTTGGATGATTAATCCTCAGAACAATGGAGCAATAAAGCAGAAGGAGTCTTTCATCTTCTGGC
AGCAGAAATCCATGAAGCCCGGGCCCAGGAAAATTAGAAGTTTTCCATTCCTGATACACTGTACACATTTTTATGCGAGAGTGGAGAACA
TTTTATTCTTGACACTTTTGTGTATATAACCCTTGGAATAGATTCTCAGAGTGATTCATTGTGTACAAGGAAGTATGAAATTAGGGCAAT
ACAGTAAATTTTCATGTTACTCTTTTATCAGATCACAAACTCCTAGAGTCTACATGCAAGACTAGTAAAGTCTTATGGAGTCTTATGATG
GATTTTTAACTTCCCGTGGAAAAAAAAATAAAGGCTGTATCTAAAATATCAAAGGTTCTATATGTCACACAATCGTAATTCCAAAAGCCA

>In-frame_ENST00000379719_ENST00000396604_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549076_length(amino acids)=85AA_start in transcript=260_stop in transcript=3

--------------------------------------------------------------
>In-frame_ENST00000379719_ENST00000530463_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549076_length(transcript)=310nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAACTTGGAGAACAGCCATCTCTGGAAGAAGCCATCAGAATAGCGTC

>In-frame_ENST00000379719_ENST00000530463_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549076_length(amino acids)=64AA_start in transcript=282_stop in transcript=88

--------------------------------------------------------------
>In-frame_ENST00000379719_ENST00000396597_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549076_length(transcript)=343nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAACTTGGAGAACAGCCATCTCTGGAAGAAGCCATCAGAATAGCGTC

>In-frame_ENST00000379719_ENST00000396597_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549076_length(amino acids)=64AA_start in transcript=282_stop in transcript=88

--------------------------------------------------------------
>In-frame_ENST00000379719_ENST00000396604_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549077_length(transcript)=751nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAACTTGGAGAACAGCCATCTCTGGAAGAAGCCATCAGAATAGCGTC
TAGAATCCAACAAGGAGAAACGCCAGGGTTGGATGATTAATCCTCAGAACAATGGAGCAATAAAGCAGAAGGAGTCTTTCATCTTCTGGC
AGCAGAAATCCATGAAGCCCGGGCCCAGGAAAATTAGAAGTTTTCCATTCCTGATACACTGTACACATTTTTATGCGAGAGTGGAGAACA
TTTTATTCTTGACACTTTTGTGTATATAACCCTTGGAATAGATTCTCAGAGTGATTCATTGTGTACAAGGAAGTATGAAATTAGGGCAAT
ACAGTAAATTTTCATGTTACTCTTTTATCAGATCACAAACTCCTAGAGTCTACATGCAAGACTAGTAAAGTCTTATGGAGTCTTATGATG
GATTTTTAACTTCCCGTGGAAAAAAAAATAAAGGCTGTATCTAAAATATCAAAGGTTCTATATGTCACACAATCGTAATTCCAAAAGCCA

>In-frame_ENST00000379719_ENST00000396604_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549077_length(amino acids)=85AA_start in transcript=260_stop in transcript=3

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>In-frame_ENST00000379719_ENST00000530463_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549077_length(transcript)=310nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAACTTGGAGAACAGCCATCTCTGGAAGAAGCCATCAGAATAGCGTC

>In-frame_ENST00000379719_ENST00000530463_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549077_length(amino acids)=64AA_start in transcript=282_stop in transcript=88

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>In-frame_ENST00000379719_ENST00000396597_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549077_length(transcript)=343nt_BP=226nt
GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT
ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC
TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAACTTGGAGAACAGCCATCTCTGGAAGAAGCCATCAGAATAGCGTC

>In-frame_ENST00000379719_ENST00000396597_TCGA-ZF-AA56_IPO7_chr11_9406394_+_ZNF143_chr11_9549077_length(amino acids)=64AA_start in transcript=282_stop in transcript=88

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Fusion Gene PPI Analysis for IPO7-ZNF143


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IPO7-ZNF143


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IPO7-ZNF143


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIPO7C0019693HIV Infections1CTD_human
HgeneIPO7C4505456HIV Coinfection1CTD_human