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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IQCE-TMCO3 (FusionGDB2 ID:39941)

Fusion Gene Summary for IQCE-TMCO3

check button Fusion gene summary
Fusion gene informationFusion gene name: IQCE-TMCO3
Fusion gene ID: 39941
HgeneTgene
Gene symbol

IQCE

TMCO3

Gene ID

23288

55002

Gene nameIQ motif containing Etransmembrane and coiled-coil domains 3
Synonyms1700028P05Rik|PAPA7C13orf11
Cytomap

7p22.3

13q34

Type of geneprotein-codingprotein-coding
DescriptionIQ domain-containing protein Etransmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting protein
Modification date2020031320200313
UniProtAcc

Q6IPM2

.
Ensembl transtripts involved in fusion geneENST00000404984, ENST00000402050, 
ENST00000438376, ENST00000325979, 
ENST00000497572, 		ENST00000434316, 
ENST00000375391, ENST00000474393, 
Fusion gene scores* DoF score7 X 6 X 6=25215 X 14 X 11=2310
# samples 724
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2310*10)=-3.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IQCE [Title/Abstract] AND TMCO3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIQCE(2613122)-TMCO3(114193672), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IQCE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMCO3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4IY-01AIQCEchr7

2613122

+TMCO3chr13

114193672

+


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Fusion Gene ORF analysis for IQCE-TMCO3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000404984ENST00000434316IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000404984ENST00000375391IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000404984ENST00000474393IQCEchr7

2613122

+TMCO3chr13

114193672

+
In-frameENST00000402050ENST00000434316IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000402050ENST00000375391IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000402050ENST00000474393IQCEchr7

2613122

+TMCO3chr13

114193672

+
In-frameENST00000438376ENST00000434316IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000438376ENST00000375391IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000438376ENST00000474393IQCEchr7

2613122

+TMCO3chr13

114193672

+
In-frameENST00000325979ENST00000434316IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000325979ENST00000375391IQCEchr7

2613122

+TMCO3chr13

114193672

+
5CDS-intronENST00000325979ENST00000474393IQCEchr7

2613122

+TMCO3chr13

114193672

+
intron-3CDSENST00000497572ENST00000434316IQCEchr7

2613122

+TMCO3chr13

114193672

+
intron-intronENST00000497572ENST00000375391IQCEchr7

2613122

+TMCO3chr13

114193672

+
intron-intronENST00000497572ENST00000474393IQCEchr7

2613122

+TMCO3chr13

114193672

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000404984IQCEchr72613122+ENST00000434316TMCO3chr13114193672+164849628990320
ENST00000402050IQCEchr72613122+ENST00000434316TMCO3chr13114193672+1801649281143371
ENST00000438376IQCEchr72613122+ENST00000434316TMCO3chr13114193672+1699547431041332
ENST00000325979IQCEchr72613122+ENST00000434316TMCO3chr13114193672+17085562081050280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000404984ENST00000434316IQCEchr72613122+TMCO3chr13114193672+0.039500510.9604995
ENST00000402050ENST00000434316IQCEchr72613122+TMCO3chr13114193672+0.0083225140.9916775
ENST00000438376ENST00000434316IQCEchr72613122+TMCO3chr13114193672+0.154684930.8453151
ENST00000325979ENST00000434316IQCEchr72613122+TMCO3chr13114193672+0.0092352320.99076474

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Fusion Genomic Features for IQCE-TMCO3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IQCEchr72613122+TMCO3chr13114193671+3.51E-060.99999654
IQCEchr72613122+TMCO3chr13114193671+3.51E-060.99999654

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IQCE-TMCO3


check button Go to

FGviewer for the breakpoints of chr7:2613122-chr13:114193672

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IQCE

Q6IPM2

.
FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108124_2040415.0Coiled coilOntology_term=ECO:0000255
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108221_2240415.0Compositional biasNote=Poly-Glu
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108286_3060415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108317_3370415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108350_3700415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108416_4360415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108456_4760415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108498_5180415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108554_5740415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108578_5980415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108608_6280415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST0000037539108640_6600415.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813554_574513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813578_598513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813608_628513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813640_660513.0678.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIQCEchr7:2613122chr13:114193672ENST00000325979+420157_26490.0631.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000325979+420292_35890.0631.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000325979+420387_47790.0631.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000402050+622157_264155.0696.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000402050+622292_358155.0696.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000402050+622387_477155.0696.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000404984+521157_264104.0645.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000404984+521292_358104.0645.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000404984+521387_477104.0645.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000438376+521157_264139.0680.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000438376+521292_358139.0680.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000438376+521387_477139.0680.0Coiled coilOntology_term=ECO:0000255
HgeneIQCEchr7:2613122chr13:114193672ENST00000325979+420534_53990.0631.0Compositional biasNote=Poly-Lys
HgeneIQCEchr7:2613122chr13:114193672ENST00000402050+622534_539155.0696.0Compositional biasNote=Poly-Lys
HgeneIQCEchr7:2613122chr13:114193672ENST00000404984+521534_539104.0645.0Compositional biasNote=Poly-Lys
HgeneIQCEchr7:2613122chr13:114193672ENST00000438376+521534_539139.0680.0Compositional biasNote=Poly-Lys
HgeneIQCEchr7:2613122chr13:114193672ENST00000325979+420542_57190.0631.0DomainIQ 1
HgeneIQCEchr7:2613122chr13:114193672ENST00000325979+420601_63090.0631.0DomainIQ 2
HgeneIQCEchr7:2613122chr13:114193672ENST00000402050+622542_571155.0696.0DomainIQ 1
HgeneIQCEchr7:2613122chr13:114193672ENST00000402050+622601_630155.0696.0DomainIQ 2
HgeneIQCEchr7:2613122chr13:114193672ENST00000404984+521542_571104.0645.0DomainIQ 1
HgeneIQCEchr7:2613122chr13:114193672ENST00000404984+521601_630104.0645.0DomainIQ 2
HgeneIQCEchr7:2613122chr13:114193672ENST00000438376+521542_571139.0680.0DomainIQ 1
HgeneIQCEchr7:2613122chr13:114193672ENST00000438376+521601_630139.0680.0DomainIQ 2
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813124_204513.0678.0Coiled coilOntology_term=ECO:0000255
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813221_224513.0678.0Compositional biasNote=Poly-Glu
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813286_306513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813317_337513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813350_370513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813416_436513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813456_476513.0678.0TransmembraneHelical
TgeneTMCO3chr7:2613122chr13:114193672ENST00000434316813498_518513.0678.0TransmembraneHelical


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Fusion Gene Sequence for IQCE-TMCO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000404984_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(transcript)=1648nt_BP=496nt
CCAGGGGGAACGCAGGTCGCTTACCCGGCTGGGTAGGTCGGCGGCCTGGTTGCCATGGCAGCGGGGTCGCGGGCCGGCGCCAGGGAAGGC
CCCGAGGCTGCGGGCGGCCAGGGCTGCCCGCGGATTCCCAGACCCGGACGCCCGAGCCAGCAACCCTGAGGGGCGGCCGGGCAGCGCCGC
CACCATGTTCCTGGGCACCGGGGAGCCGGCCTTGGACACGAGTCACCTTATCTCTCTAAGCCGAGCGTCCCTGACCCCGCAGAAGCTGTG
GCTGGGAACCGCAAAGCCAGGAAGTCTGACCCAGGCCCTGAACTCACCCCTCACCTGGGAGCATGCGTGGACTGGCGTCCCCGGCGGCAC
TCCTGACTGTCTGACAGACACCTTCAGAGTGAAGAGGCCACATCTCAGGCGCTCTGCCAGCAACGGTCATGTCCCTGGGACTCCTGTCTA
CAGAGAAAAAGAAGATATGTATGACGAGATTATTGAGTTAAAGAAGGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCT
GGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGT
TTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGT
GATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGC
CCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGT
GACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTG
ATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGC
ACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATT
TTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGA
TGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTA
AAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCC
TGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGT
AACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCACTTAAAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTA

>In-frame_ENST00000404984_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(amino acids)=320AA_start in transcript=28_stop in transcript=990
MGRSAAWLPWQRGRGPAPGKAPRLRAARAARGFPDPDARASNPEGRPGSAATMFLGTGEPALDTSHLISLSRASLTPQKLWLGTAKPGSL
TQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKVTELLDVSMELGCFLAGALVSSQG
PVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVL

--------------------------------------------------------------
>In-frame_ENST00000402050_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(transcript)=1801nt_BP=649nt
CCAGGGGGAACGCAGGTCGCTTACCCGGCTGGGTAGGTCGGCGGCCTGGTTGCCATGGCAGCGGGGTCGCGGGCCGGCGCCAGGGAAGGC
CCCGAGGCTGCGGGCGGCCAGGGCTGCCCGCGGATTCCCAGACCCGGACGCCCGAGCCAGCAACCCTGAGGGGCGGCCGGGCAGCGCCGC
CACCATGTTCCTGGGCACCGGGGAGCCGGCCTTGGACACGGGAGATGACAGTCTGTCTGCAGTCACCTTTGACTCTGATGTGGAGACGAA
AGCAAAAAGGAAAGCTTTCCACAAACCTCCACCCACATCGCCAAAGTCACCTTATCTCTCTAAGCCGAGAAAAGTGGCCTCCTGGAGGTC
CCTCAGGACGGCAGGGAGCATGCCTCTGGGCGGCCGAGCGTCCCTGACCCCGCAGAAGCTGTGGCTGGGAACCGCAAAGCCAGGAAGTCT
GACCCAGGCCCTGAACTCACCCCTCACCTGGGAGCATGCGTGGACTGGCGTCCCCGGCGGCACTCCTGACTGTCTGACAGACACCTTCAG
AGTGAAGAGGCCACATCTCAGGCGCTCTGCCAGCAACGGTCATGTCCCTGGGACTCCTGTCTACAGAGAAAAAGAAGATATGTATGACGA
GATTATTGAGTTAAAGAAGGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGG
CCCCGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGT
GTTCCCCACGTTTGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGT
CCTGTCTCTCATTCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCT
GGGGAGCCGGGCGCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCC
GGTGCTGTGGAGAGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAA
GGGAAGCGTCTGTGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGC
AGAGCGTCAGTGCAGTCGTGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGT
TGATTATGTGCAGTAGACCCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAAT
TATTATTAATTTTCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCA
GAATTATAATCTGTTAGTCAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTT
GATTCTTAAAGCCTATGTTTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTC
AATTTCTATTAGATATATCACTTAAAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAATAAAGATAATTTATGATCATGGTATA

>In-frame_ENST00000402050_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(amino acids)=371AA_start in transcript=28_stop in transcript=1143
MGRSAAWLPWQRGRGPAPGKAPRLRAARAARGFPDPDARASNPEGRPGSAATMFLGTGEPALDTGDDSLSAVTFDSDVETKAKRKAFHKP
PPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRS
ASNGHVPGTPVYREKEDMYDEIIELKKVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYEL
TVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLAPVLWRAAITR

--------------------------------------------------------------
>In-frame_ENST00000438376_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(transcript)=1699nt_BP=547nt
ATGGCAGCGGGGTCGCGGGCCGGCGCCAGGGAAGGCCCCGAGGCTGCGGGCGGCCAGGGCTGCCCGCGGATTCCCAGACCCGGACGCCCG
AGCCAGCAACCCTGAGGGGCGGCCGGGCAGCGCCGCCACCATGTTCCTGGGCACCGGGGAGCCGGCCTTGGACACGAAAGCAAAAAGGAA
AGCTTTCCACAAACCTCCACCCACATCGCCAAAGTCACCTTATCTCTCTAAGCCGAGAAAAGTGGCCTCCTGGAGGTCCCTCAGGACGGC
AGGGAGCATGCCTCTGGGCGGCCGAGCGTCCCTGACCCCGCAGAAGCTGTGGCTGGGAACCGCAAAGCCAGGAAGTCTGACCCAGGCCCT
GAACTCACCCCTCACCTGGGAGCATGCGTGGACTGGCGTCCCCGGCGGCACTCCTGACTGTCTGACAGACACCTTCAGAGTGAAGAGGCC
ACATCTCAGGCGCTCTGCCAGCAACGGTCATGTCCCTGGGACTCCTGTCTACAGAGAAAAAGAAGATATGTATGACGAGATTATTGAGTT
AAAGAAGGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCAC
CGAGGAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTT
TGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCAT
TCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGC
GCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAG
AGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTG
TGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTG
CAGTCGTGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCA
GTAGACCCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTT
TCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCT
GTTAGTCAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGC
CTATGTTTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAG

>In-frame_ENST00000438376_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(amino acids)=332AA_start in transcript=43_stop in transcript=1041
MRAARAARGFPDPDARASNPEGRPGSAATMFLGTGEPALDTKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQ
KLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKVTELLDVSMELG
CFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSA

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>In-frame_ENST00000325979_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(transcript)=1708nt_BP=556nt
CGCAGAGGCCGCCGCTTCCAGGAAGCTCTCCGGGACGCCGCGCCCTCGCCTCTGGGCGCCTGCGAGTCTGCGGCCCGCAGGTGACGGAGC
TCACGGTAATGTTTGACTAGAGTCACCACGCTCGTGGATTTTGTTTTCCTATTTCTGTCTTTCTGAAGTTCATGTGTTGAGCTCACATGT
TGCTGTCCGGCACCTCTGAATCCACGTGTTGGCTTTTCCAGAGTCACCTTATCTCTCTAAGCCGAGAAAAGTGGCCTCCTGGAGGTCCCT
CAGGACGGCAGGGAGCATGCCTCTGGGCGGCCGAGCGTCCCTGACCCCGCAGAAGCTGTGGCTGGGAACCGCAAAGCCAGGAAGTCTGAC
CCAGGCCCTGAACTCACCCCTCACCTGGGAGCATGCGTGGACTGGCGTCCCCGGCGGCACTCCTGACTGTCTGACAGACACCTTCAGAGT
GAAGAGGCCACATCTCAGGCGCTCTGCCAGCAACGGTCATGTCCCTGGGACTCCTGTCTACAGAGAAAAAGAAGATATGTATGACGAGAT
TATTGAGTTAAAGAAGGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCC
CGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTT
CCCCACGTTTGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCT
GTCTCTCATTCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGG
GAGCCGGGCGCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGT
GCTGTGGAGAGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGG
AAGCGTCTGTGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGA
GCGTCAGTGCAGTCGTGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGA
TTATGTGCAGTAGACCCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTAT
TATTAATTTTCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAA
TTATAATCTGTTAGTCAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGAT
TCTTAAAGCCTATGTTTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAAT

>In-frame_ENST00000325979_ENST00000434316_TCGA-BR-A4IY-01A_IQCE_chr7_2613122_+_TMCO3_chr13_114193672_length(amino acids)=280AA_start in transcript=208_stop in transcript=1050
MAFPESPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSA
SNGHVPGTPVYREKEDMYDEIIELKKVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELT
VLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLAPVLWRAAITRC

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Fusion Gene PPI Analysis for IQCE-TMCO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IQCE-TMCO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IQCE-TMCO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIQCEC3887487Postaxial polydactyly type A2ORPHANET
HgeneIQCEC4539976POLYDACTYLY, POSTAXIAL, TYPE A71GENOMICS_ENGLAND