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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IQCK-INTS10 (FusionGDB2 ID:39976)

Fusion Gene Summary for IQCK-INTS10

Fusion gene summary

Fusion gene information	Fusion gene name: IQCK-INTS10
	Fusion gene ID: 39976
		Hgene	Tgene
	Gene symbol	IQCK	INTS10
	Gene ID	124152	55174
	Gene name	IQ motif containing K	integrator complex subunit 10
	Synonyms	-	C8orf35\|INT10
	Cytomap	16p12.3	8p21.3
	Type of gene	protein-coding	protein-coding
	Description	IQ domain-containing protein K	integrator complex subunit 10
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NVR2
	Ensembl transtripts involved in fusion gene	ENST00000320394, ENST00000564186, ENST00000541926, ENST00000433597, ENST00000562762,	ENST00000397977, ENST00000521758,
Fusion gene scores	* DoF score	10 X 12 X 6=720	8 X 6 X 7=336
	# samples	12	8
	** MAII score	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IQCK [Title/Abstract] AND INTS10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IQCK(19745149)-INTS10(19703215), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	INTS10	GO:0016180	snRNA processing	16239144

Fusion gene breakpoints across IQCK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across INTS10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-02-2486-01A	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+

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Fusion Gene ORF analysis for IQCK-INTS10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000320394	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
5CDS-intron	ENST00000320394	ENST00000521758	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
In-frame	ENST00000564186	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
5CDS-intron	ENST00000564186	ENST00000521758	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
In-frame	ENST00000541926	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
5CDS-intron	ENST00000541926	ENST00000521758	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
In-frame	ENST00000433597	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
5CDS-intron	ENST00000433597	ENST00000521758	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
intron-3CDS	ENST00000562762	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+
intron-intron	ENST00000562762	ENST00000521758	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000320394

IQCK

chr16

19745149

ENST00000397977

INTS10

chr8

19703215

1599

1075

192

1325

377

ENST00000564186

IQCK

chr16

19745149

ENST00000397977

INTS10

chr8

19703215

927

403

653

208

ENST00000541926

IQCK

chr16

19745149

ENST00000397977

INTS10

chr8

19703215

922

398

648

208

ENST00000433597

IQCK

chr16

19745149

ENST00000397977

INTS10

chr8

19703215

827

303

110

553

147

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000320394	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+	0.016512394	0.98348755
ENST00000564186	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+	0.006828697	0.99317133
ENST00000541926	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+	0.006905924	0.9930941
ENST00000433597	ENST00000397977	IQCK	chr16	19745149	+	INTS10	chr8	19703215	+	0.059851028	0.94014895

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Fusion Genomic Features for IQCK-INTS10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IQCK	chr16	19745149	+	INTS10	chr8	19703214	+	0.56079024	0.4392098
IQCK	chr16	19745149	+	INTS10	chr8	19703214	+	0.56079024	0.4392098

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IQCK-INTS10

Go to
FGviewer for the breakpoints of chr16:19745149-chr8:19703215
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	INTS10 Q9NVR2
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). {ECO:0000269\|PubMed:23904267, ECO:0000305\|PubMed:16239144}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

INTS10

chr16:19745149

chr8:19703215

ENST00000397977

132_136

627.3333333333334

711.0

Compositional bias

Note=Poly-Leu

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Fusion Gene Sequence for IQCK-INTS10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000320394_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(transcript)=1599nt_BP=1075nt
ATTAATCCCTGAGACAAAGGTACTGAAGGCAAGTGGCTGAAGAACAGGCTTGATTGGACAGATGACTTGGAGATGTTCACTGGACAGGGA
CAGCCTTGTGAAGATCTTTGTGAATACCCGACCTCGCAAGCTCCAGAGACTACAATAATTCACTTGCCCTAGGTTCCAAAGCCAGCAAGT
GGAAAACGGAGACTGGAATTCCGCCCACAGGACTCCAAAGCCTGTGCAGCAACACCCCACTCCCCCGGCAGGATCACCAGCAGGACGCGC
GGGAGCCAGGAAGTAAGATCCGTACCTCCAAGGCTCCCATGGGCCCAAGCCTCCGCATCAACAGACTGGGAGGGATTACGTGGGGTCCCA
GGGCCGGCTCTGAGGCGGGAAAACTTTCTGGAGGCGGCGGCCTCAGGCCGGAGCGGGCGCACACCGACTGGAGGGGTCGGATTCAGGGAT
GTGGGTGGACCGCATTTCCCCATCTTCCCCGCCGCGCACTTCCTCTGGTGCAATCTCCACACCCCGCGCCGGCCCGCCTGCAACGCGCCC
TGGCACTCACCGGTGGGCGAAATTTCCCCGCCTCCACGTGAGAGCCAGCTCCGCCGTGACCCGGAAGTCCACTTCGAGTCGCCGGCCCAC
CCTCTCGGGTTCCGGCTTCTTCCGGGTCGCGGCCTTCCGGCGAACGCGGTTACCGTGGAAACCGCGGCCATGGCGGCACCGCGGCAAATC
CCCAGCCACATAGTGCGCCTCAAGCCCAGCTGCTCTACAGACTCGTCGTTCACCCGGACGCCGGTGCCCACCGTGTCTCTCGCGTCCCGC
GAGCTGCCTGTCTCGTCGTGGCAGGTCACCGAGCCGTCAAGCAAGAATCTGTGGGAGCAGATCTGCAAGGAGTATGAAGCTGAGCAGCCT
CCCTTTCCAGAAGGATATAAAGTCAAACAGGAGCCTGTGATTACGGTTGCGCCAGTAGAGGAAATGCTTTTTCATGGCTTCAGTGCAGAG
CACTATTTTCCGGTTTCCCATTTCACCATGATCTCACGTACACCCTGTCCTCAAGATAAATCGGAAACAATCAACCCAAAAACATATATT
GATATGCTGGAGGAATTTGCCTACTTGAGAACTCAGGAAGGTGGGAAAATTCATCTGGAATTACTACCCAATCAAGGAATGCTGATCAAG
CACCACACTGTAACTCGAGGCATCACCAAAGGCGTGAAGGAGGACTTTCGCCTGGCCATGGAGCGCCAGGTCTCCCGCTGTGGAGAGAAT
CTGATGGTGGTTCTGCACAGGTTCTGCATTAATGAGAAGATCTTGCTCCTTCAGACTCTGACCTGAGTGGAGACCTTTCCACCAGACACA
GCTCGGGCCTGTGTAATTGTAGGAGAAGACACTCAGCAGTGATTGCCATGGCACAGAGCCGTGGTCATTGTTGCTGTTACAAAGAAGAAA
ACCATCTGAGTTCTAACTCCTTGGTTGCTTAAAAGTAGTTCCCAAGAGTCTGAGAAGCTATTTCTATTTTTAAGAGTCATTTTTTGTAAT

>In-frame_ENST00000320394_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(amino acids)=377AA_start in transcript=192_stop in transcript=1325
MEFRPQDSKACAATPHSPGRITSRTRGSQEVRSVPPRLPWAQASASTDWEGLRGVPGPALRRENFLEAAASGRSGRTPTGGVGFRDVGGP
HFPIFPAAHFLWCNLHTPRRPACNAPWHSPVGEISPPPRESQLRRDPEVHFESPAHPLGFRLLPGRGLPANAVTVETAAMAAPRQIPSHI
VRLKPSCSTDSSFTRTPVPTVSLASRELPVSSWQVTEPSSKNLWEQICKEYEAEQPPFPEGYKVKQEPVITVAPVEEMLFHGFSAEHYFP
VSHFTMISRTPCPQDKSETINPKTYIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMVV

--------------------------------------------------------------
>In-frame_ENST00000564186_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(transcript)=927nt_BP=403nt
AACGCGGTTACCGTGGAAACCGCGGCCATGGCGGCACCGCGGCAAATCCCCAGCCACATAGTGCGCCTCAAGCCCAGCTGCTCTACAGAC
TCGTCGTTCACCCGGACGCCGGTGCCCACCGTGTCTCTCGCGTCCCGCGAGCTGCCTGTCTCGTCGTGGCAGGTCACCGAGCCGTCAAGC
AAGAATCTGTGGGAGCAGATCTGCAAGGAGTATGAAGCTGAGCAGCCTCCCTTTCCAGAAGGATATAAAGTCAAACAGGAGCCTGTGATT
ACGGTTGCGCCAGTAGAGGAAATGCTTTTTCATGGCTTCAGTGCAGAGCACTATTTTCCGGTTTCCCATTTCACCATGATCTCACGTACA
CCCTGTCCTCAAGATAAATCGGAAACAATCAACCCAAAAACATATATTGATATGCTGGAGGAATTTGCCTACTTGAGAACTCAGGAAGGT
GGGAAAATTCATCTGGAATTACTACCCAATCAAGGAATGCTGATCAAGCACCACACTGTAACTCGAGGCATCACCAAAGGCGTGAAGGAG
GACTTTCGCCTGGCCATGGAGCGCCAGGTCTCCCGCTGTGGAGAGAATCTGATGGTGGTTCTGCACAGGTTCTGCATTAATGAGAAGATC
TTGCTCCTTCAGACTCTGACCTGAGTGGAGACCTTTCCACCAGACACAGCTCGGGCCTGTGTAATTGTAGGAGAAGACACTCAGCAGTGA
TTGCCATGGCACAGAGCCGTGGTCATTGTTGCTGTTACAAAGAAGAAAACCATCTGAGTTCTAACTCCTTGGTTGCTTAAAAGTAGTTCC
CAAGAGTCTGAGAAGCTATTTCTATTTTTAAGAGTCATTTTTTGTAATTTTTGTAAAACAAAAGTACCAATCTGTTTTGTAAATAAAAAT

>In-frame_ENST00000564186_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(amino acids)=208AA_start in transcript=27_stop in transcript=653
MAAPRQIPSHIVRLKPSCSTDSSFTRTPVPTVSLASRELPVSSWQVTEPSSKNLWEQICKEYEAEQPPFPEGYKVKQEPVITVAPVEEML
FHGFSAEHYFPVSHFTMISRTPCPQDKSETINPKTYIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQ

--------------------------------------------------------------
>In-frame_ENST00000541926_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(transcript)=922nt_BP=398nt
GGTTACCGTGGAAACCGCGGCCATGGCGGCACCGCGGCAAATCCCCAGCCACATAGTGCGCCTCAAGCCCAGCTGCTCTACAGACTCGTC
GTTCACCCGGACGCCGGTGCCCACCGTGTCTCTCGCGTCCCGCGAGCTGCCTGTCTCGTCGTGGCAGGTCACCGAGCCGTCAAGCAAGAA
TCTGTGGGAGCAGATCTGCAAGGAGTATGAAGCTGAGCAGCCTCCCTTTCCAGAAGGATATAAAGTCAAACAGGAGCCTGTGATTACGGT
TGCGCCAGTAGAGGAAATGCTTTTTCATGGCTTCAGTGCAGAGCACTATTTTCCGGTTTCCCATTTCACCATGATCTCACGTACACCCTG
TCCTCAAGATAAATCGGAAACAATCAACCCAAAAACATATATTGATATGCTGGAGGAATTTGCCTACTTGAGAACTCAGGAAGGTGGGAA
AATTCATCTGGAATTACTACCCAATCAAGGAATGCTGATCAAGCACCACACTGTAACTCGAGGCATCACCAAAGGCGTGAAGGAGGACTT
TCGCCTGGCCATGGAGCGCCAGGTCTCCCGCTGTGGAGAGAATCTGATGGTGGTTCTGCACAGGTTCTGCATTAATGAGAAGATCTTGCT
CCTTCAGACTCTGACCTGAGTGGAGACCTTTCCACCAGACACAGCTCGGGCCTGTGTAATTGTAGGAGAAGACACTCAGCAGTGATTGCC
ATGGCACAGAGCCGTGGTCATTGTTGCTGTTACAAAGAAGAAAACCATCTGAGTTCTAACTCCTTGGTTGCTTAAAAGTAGTTCCCAAGA
GTCTGAGAAGCTATTTCTATTTTTAAGAGTCATTTTTTGTAATTTTTGTAAAACAAAAGTACCAATCTGTTTTGTAAATAAAAATCATCC

>In-frame_ENST00000541926_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(amino acids)=208AA_start in transcript=22_stop in transcript=648
MAAPRQIPSHIVRLKPSCSTDSSFTRTPVPTVSLASRELPVSSWQVTEPSSKNLWEQICKEYEAEQPPFPEGYKVKQEPVITVAPVEEML
FHGFSAEHYFPVSHFTMISRTPCPQDKSETINPKTYIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQ

--------------------------------------------------------------
>In-frame_ENST00000433597_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(transcript)=827nt_BP=303nt
ACCGCGGCAAATCCCCAGCCACATAGTGCGCCTCAAGCCCAGCTGCTCTACAGACTCGTCGTTCACCCGGACGCCGGTGCCCACCGTGTC
TCTCGCGTCCCGCGAGCTGCCTGTCTCGTCGTGGCAGGTCACCGAGCCGTCAAGCAAGAATCTGTGGGAGCAGATCTGCAAGGGTTGCGC
CAGTAGAGGAAATGCTTTTTCATGGCTTCAGTGCAGAGCACTATTTTCCGGTTTCCCATTTCACCATGATCTCACGTACACCCTGTCCTC
AAGATAAATCGGAAACAATCAACCCAAAAACATATATTGATATGCTGGAGGAATTTGCCTACTTGAGAACTCAGGAAGGTGGGAAAATTC
ATCTGGAATTACTACCCAATCAAGGAATGCTGATCAAGCACCACACTGTAACTCGAGGCATCACCAAAGGCGTGAAGGAGGACTTTCGCC
TGGCCATGGAGCGCCAGGTCTCCCGCTGTGGAGAGAATCTGATGGTGGTTCTGCACAGGTTCTGCATTAATGAGAAGATCTTGCTCCTTC
AGACTCTGACCTGAGTGGAGACCTTTCCACCAGACACAGCTCGGGCCTGTGTAATTGTAGGAGAAGACACTCAGCAGTGATTGCCATGGC
ACAGAGCCGTGGTCATTGTTGCTGTTACAAAGAAGAAAACCATCTGAGTTCTAACTCCTTGGTTGCTTAAAAGTAGTTCCCAAGAGTCTG
AGAAGCTATTTCTATTTTTAAGAGTCATTTTTTGTAATTTTTGTAAAACAAAAGTACCAATCTGTTTTGTAAATAAAAATCATCCTAAAA

>In-frame_ENST00000433597_ENST00000397977_TCGA-02-2486-01A_IQCK_chr16_19745149_+_INTS10_chr8_19703215_length(amino acids)=147AA_start in transcript=110_stop in transcript=553
MSRRGRSPSRQARICGSRSARVAPVEEMLFHGFSAEHYFPVSHFTMISRTPCPQDKSETINPKTYIDMLEEFAYLRTQEGGKIHLELLPN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IQCK-INTS10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IQCK-INTS10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IQCK-INTS10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	IQCK	C0002395	Alzheimer's Disease	1	CTD_human
Hgene	IQCK	C0011265	Presenile dementia	1	CTD_human
Hgene	IQCK	C0276496	Familial Alzheimer Disease (FAD)	1	CTD_human
Hgene	IQCK	C0494463	Alzheimer Disease, Late Onset	1	CTD_human
Hgene	IQCK	C0546126	Acute Confusional Senile Dementia	1	CTD_human
Hgene	IQCK	C0750900	Alzheimer's Disease, Focal Onset	1	CTD_human
Hgene	IQCK	C0750901	Alzheimer Disease, Early Onset	1	CTD_human