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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IQGAP1-TDRD5 (FusionGDB2 ID:39998)

Fusion Gene Summary for IQGAP1-TDRD5

check button Fusion gene summary
Fusion gene informationFusion gene name: IQGAP1-TDRD5
Fusion gene ID: 39998
HgeneTgene
Gene symbol

IQGAP1

TDRD5

Gene ID

8826

163589

Gene nameIQ motif containing GTPase activating protein 1tudor domain containing 5
SynonymsHUMORFA01|SAR1|p195TUDOR3
Cytomap

15q26.1

1q25.2

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifstudor domain-containing protein 5testicular tissue protein Li 194
Modification date2020032720200313
UniProtAcc

P46940

.
Ensembl transtripts involved in fusion geneENST00000268182, ENST00000560738, 
ENST00000560020, 		ENST00000367614, 
ENST00000444136, ENST00000294848, 
Fusion gene scores* DoF score27 X 20 X 12=64802 X 3 X 2=12
# samples 323
** MAII scorelog2(32/6480*10)=-4.33985000288463
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IQGAP1 [Title/Abstract] AND TDRD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIQGAP1(90969498)-TDRD5(179620002), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIQGAP1

GO:0071277

cellular response to calcium ion

18567582


check buttonFusion gene breakpoints across IQGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TDRD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01AIQGAP1chr15

90969498

+TDRD5chr1

179620002

+


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Fusion Gene ORF analysis for IQGAP1-TDRD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000268182ENST00000367614IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
In-frameENST00000268182ENST00000444136IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
In-frameENST00000268182ENST00000294848IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
intron-3CDSENST00000560738ENST00000367614IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
intron-3CDSENST00000560738ENST00000444136IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
intron-3CDSENST00000560738ENST00000294848IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
intron-3CDSENST00000560020ENST00000367614IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
intron-3CDSENST00000560020ENST00000444136IQGAP1chr15

90969498

+TDRD5chr1

179620002

+
intron-3CDSENST00000560020ENST00000294848IQGAP1chr15

90969498

+TDRD5chr1

179620002

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268182IQGAP1chr1590969498+ENST00000367614TDRD5chr1179620002+19094361241581485
ENST00000268182IQGAP1chr1590969498+ENST00000444136TDRD5chr1179620002+20644361241743539
ENST00000268182IQGAP1chr1590969498+ENST00000294848TDRD5chr1179620002+19114361241581485

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268182ENST00000367614IQGAP1chr1590969498+TDRD5chr1179620002+0.0007683370.9992317
ENST00000268182ENST00000444136IQGAP1chr1590969498+TDRD5chr1179620002+0.0006004710.99939954
ENST00000268182ENST00000294848IQGAP1chr1590969498+TDRD5chr1179620002+0.000749090.9992508

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Fusion Genomic Features for IQGAP1-TDRD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IQGAP1chr1590969498+TDRD5chr1179620001+1.82E-081
IQGAP1chr1590969498+TDRD5chr1179620001+1.82E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IQGAP1-TDRD5


check button Go to

FGviewer for the breakpoints of chr15:90969498-chr1:179620002

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IQGAP1

P46940

.
FUNCTION: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+3381004_1237104.01658.0DomainRas-GAP
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+33844_159104.01658.0DomainCalponin-homology (CH)
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+338679_712104.01658.0DomainWW
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+338745_774104.01658.0DomainIQ 1
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+338775_804104.01658.0DomainIQ 2
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+338805_834104.01658.0DomainIQ 3
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+338835_864104.01658.0DomainIQ 4
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+3381276_1657104.01658.0RegionNote=C2
HgeneIQGAP1chr15:90969498chr1:179620002ENST00000268182+338956_1274104.01658.0RegionNote=C1
TgeneTDRD5chr15:90969498chr1:179620002ENST000002948481017127_202600.0982.0DomainHTH OST-type 2
TgeneTDRD5chr15:90969498chr1:179620002ENST000002948481017295_369600.0982.0DomainHTH OST-type 3
TgeneTDRD5chr15:90969498chr1:179620002ENST000002948481017525_584600.0982.0DomainTudor
TgeneTDRD5chr15:90969498chr1:179620002ENST0000029484810177_80600.0982.0DomainHTH OST-type 1
TgeneTDRD5chr15:90969498chr1:179620002ENST000003676141017127_202600.0982.0DomainHTH OST-type 2
TgeneTDRD5chr15:90969498chr1:179620002ENST000003676141017295_369600.0982.0DomainHTH OST-type 3
TgeneTDRD5chr15:90969498chr1:179620002ENST000003676141017525_584600.0982.0DomainTudor
TgeneTDRD5chr15:90969498chr1:179620002ENST0000036761410177_80600.0982.0DomainHTH OST-type 1
TgeneTDRD5chr15:90969498chr1:179620002ENST000004441361018127_202600.01036.0DomainHTH OST-type 2
TgeneTDRD5chr15:90969498chr1:179620002ENST000004441361018295_369600.01036.0DomainHTH OST-type 3
TgeneTDRD5chr15:90969498chr1:179620002ENST000004441361018525_584600.01036.0DomainTudor
TgeneTDRD5chr15:90969498chr1:179620002ENST0000044413610187_80600.01036.0DomainHTH OST-type 1


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Fusion Gene Sequence for IQGAP1-TDRD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000268182_ENST00000367614_TCGA-BR-A4PE-01A_IQGAP1_chr15_90969498_+_TDRD5_chr1_179620002_length(transcript)=1909nt_BP=436nt
GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA
CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC
TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA
AGCGAAGAGGTGGATGGAAGCATGCCTAGGGGAAGATCTGCCTCCCACCACAGAACTGGAGGAGGGGCTTAGGAATGGGGTCTACCTTGC
CAAACTGGGGAACTTCTTCTCTCCCAAAGTAGTGTCCCTGAAAAAAATCTATGATCGAGAACAGACCAGATACAAGGAACACTGGACATC
GAAAGCTATTTTGCAGTTCCAGAAGTTGTGCGGTTTGAAGCCATTAGTGGGGGTAGTGGATGAATATGTAGATGGAATCCTTAACATTTT
TTTGTGTGACACATCCTCAAACGAAGATGTCTATTTCCATCATGTCTTGAGAACAGAGGGCCATGCTATTGTATGCCGAGAAAATATCTC
TTCTAAGGGTTTCAGTGAGCTCAACCCTTTAGCTTTATACACGACATCCAGTGGAGGGCCAGAGGACATTGTCTTGACAGAACTGGGTTA
TCCTTCCCAGCAGCACTATTTTAATGAAGACCGAAAGATAAGTCCACAGTCAAAAGAGAGTGAGTTACGTATCTTGGATGAGATCCCCAC
TGGAATGCCATGCCTGGAGTCAGTGACCATAGGTGATGATATTTGGGATGAGAACTGGTTACCTCTACAGGCTAAGATGGGAAAAGGAGG
TGATGCTGCCTCCCATCTATTTACTGCAAGCCTTGGTGGAAAGAATCAGTATTCATCATGTAAAGAAATGCCACAGAAGGACTGGTGTTT
TTCTACCCCTAAAGATACATGGGATGATTCTTGGCAGCCTTCAGGCCTTGTAAATGGAACGAAAGTAGAAGTTCATAAGCCAGAAGTACT
GGGTGCTCAGGAAAAAAATACTGGCACAAACAGGACTCAAAAGCAACTAGACATAAATGGTTCTTCAGATTCTTCCACACTGCCCAAATT
GGAAGAATTCTGTACCTCTCTTACCCAGTCAGAGCAGTCAGCAGACGGGAGCCAGTCTGAACCCAACAACAGTCAGACTCAGCCAAAGCA
AATTCAGCTTTCCACAGCAGCACCCTGTTCAACAACTGCAGTGGATGATTCCGCAGAAAAGCCCTCTGGTTCTGTGGAAAGCTCACCAGA
GATCCTAAAGAATGAAGATTTTTCTAGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGAT
TTTGTCTTATGAGTGCCAGATTTCTCAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTAC
ATCCAGGAGCCTCCTACACTGGTACCCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCG
CTTAGGCTTTGATGAACTCCCAGGCCAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACT
ATATGTTAGCTTTATTATGCTAACAGTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATT
CTGTGTCATTTTGTTCACCTTTGTTTTTAATGTAGTTTAAAGGAATTTGTTTTTTTGTGTTTGTTTTTCTTGTACATTATCATGACTGAT

>In-frame_ENST00000268182_ENST00000367614_TCGA-BR-A4PE-01A_IQGAP1_chr15_90969498_+_TDRD5_chr1_179620002_length(amino acids)=485AA_start in transcript=124_stop in transcript=1581
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLA
LYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILDEIPTGMPCLESVTIGDDIWDENWLPLQAKMGKGGDAASHLFTASL
GGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSE
QSADGSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDSAEKPSGSVESSPEILKNEDFSSSRAITLYKDKRQESVDQLSLILSYECQISQKL

--------------------------------------------------------------
>In-frame_ENST00000268182_ENST00000444136_TCGA-BR-A4PE-01A_IQGAP1_chr15_90969498_+_TDRD5_chr1_179620002_length(transcript)=2064nt_BP=436nt
GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA
CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC
TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA
AGCGAAGAGGTGGATGGAAGCATGCCTAGGGGAAGATCTGCCTCCCACCACAGAACTGGAGGAGGGGCTTAGGAATGGGGTCTACCTTGC
CAAACTGGGGAACTTCTTCTCTCCCAAAGTAGTGTCCCTGAAAAAAATCTATGATCGAGAACAGACCAGATACAAGGAACACTGGACATC
GAAAGCTATTTTGCAGTTCCAGAAGTTGTGCGGTTTGAAGCCATTAGTGGGGGTAGTGGATGAATATGTAGATGGAATCCTTAACATTTT
TTTGTGTGACACATCCTCAAACGAAGATGTCTATTTCCATCATGTCTTGAGAACAGAGGGCCATGCTATTGTATGCCGAGAAAATATCTC
TTCTAAGGGTTTCAGTGAGCTCAACCCTTTAGCTTTATACACGACATCCAGTGGAGGGCCAGAGGACATTGTCTTGACAGAACTGGGTTA
TCCTTCCCAGCAGCACTATTTTAATGAAGACCGAAAGATAAGTCCACAGTCAAAAGAGAGTGAGTTACGTATCTTGCAAGATATTAATGA
TGAAAAGTCTTTAAGTCATCTTAAATCTGAGTCAAAGGAGCCATTAAAGGATTCTGAATTTGAGTCTTTGAAAACCTGTAATAAGAGCTT
TGAAGAAGATCCAAAGTGGTCCAACCCAGAACCAAACGATCTGAAGGAAGAAAATGAGGATGAGATCCCCACTGGAATGCCATGCCTGGA
GTCAGTGACCATAGGTGATGATATTTGGGATGAGAACTGGTTACCTCTACAGGCTAAGATGGGAAAAGGAGGTGATGCTGCCTCCCATCT
ATTTACTGCAAGCCTTGGTGGAAAGAATCAGTATTCATCATGTAAAGAAATGCCACAGAAGGACTGGTGTTTTTCTACCCCTAAAGATAC
ATGGGATGATTCTTGGCAGCCTTCAGGCCTTGTAAATGGAACGAAAGTAGAAGTTCATAAGCCAGAAGTACTGGGTGCTCAGGAAAAAAA
TACTGGCACAAACAGGACTCAAAAGCAACTAGACATAAATGGTTCTTCAGATTCTTCCACACTGCCCAAATTGGAAGAATTCTGTACCTC
TCTTACCCAGTCAGAGCAGTCAGCAGACGGGAGCCAGTCTGAACCCAACAACAGTCAGACTCAGCCAAAGCAAATTCAGCTTTCCACAGC
AGCACCCTGTTCAACAACTGCAGTGGATGATTCCGCAGAAAAGCCCTCTGGTTCTGTGGAAAGCTCACCAGAGATCCTAAAGAATGAAGA
TTTTTCTAGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGATTTTGTCTTATGAGTGCCA
GATTTCTCAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTACATCCAGGAGCCTCCTACA
CTGGTACCCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCGCTTAGGCTTTGATGAACT
CCCAGGCCAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACTATATGTTAGCTTTATTAT
GCTAACAGTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATTCTGTGTCATTTTGTTCAC

>In-frame_ENST00000268182_ENST00000444136_TCGA-BR-A4PE-01A_IQGAP1_chr15_90969498_+_TDRD5_chr1_179620002_length(amino acids)=539AA_start in transcript=124_stop in transcript=1743
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLA
LYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILQDINDEKSLSHLKSESKEPLKDSEFESLKTCNKSFEEDPKWSNPEP
NDLKEENEDEIPTGMPCLESVTIGDDIWDENWLPLQAKMGKGGDAASHLFTASLGGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLV
NGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDS

--------------------------------------------------------------
>In-frame_ENST00000268182_ENST00000294848_TCGA-BR-A4PE-01A_IQGAP1_chr15_90969498_+_TDRD5_chr1_179620002_length(transcript)=1911nt_BP=436nt
GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA
CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC
TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA
AGCGAAGAGGTGGATGGAAGCATGCCTAGGGGAAGATCTGCCTCCCACCACAGAACTGGAGGAGGGGCTTAGGAATGGGGTCTACCTTGC
CAAACTGGGGAACTTCTTCTCTCCCAAAGTAGTGTCCCTGAAAAAAATCTATGATCGAGAACAGACCAGATACAAGGAACACTGGACATC
GAAAGCTATTTTGCAGTTCCAGAAGTTGTGCGGTTTGAAGCCATTAGTGGGGGTAGTGGATGAATATGTAGATGGAATCCTTAACATTTT
TTTGTGTGACACATCCTCAAACGAAGATGTCTATTTCCATCATGTCTTGAGAACAGAGGGCCATGCTATTGTATGCCGAGAAAATATCTC
TTCTAAGGGTTTCAGTGAGCTCAACCCTTTAGCTTTATACACGACATCCAGTGGAGGGCCAGAGGACATTGTCTTGACAGAACTGGGTTA
TCCTTCCCAGCAGCACTATTTTAATGAAGACCGAAAGATAAGTCCACAGTCAAAAGAGAGTGAGTTACGTATCTTGGATGAGATCCCCAC
TGGAATGCCATGCCTGGAGTCAGTGACCATAGGTGATGATATTTGGGATGAGAACTGGTTACCTCTACAGGCTAAGATGGGAAAAGGAGG
TGATGCTGCCTCCCATCTATTTACTGCAAGCCTTGGTGGAAAGAATCAGTATTCATCATGTAAAGAAATGCCACAGAAGGACTGGTGTTT
TTCTACCCCTAAAGATACATGGGATGATTCTTGGCAGCCTTCAGGCCTTGTAAATGGAACGAAAGTAGAAGTTCATAAGCCAGAAGTACT
GGGTGCTCAGGAAAAAAATACTGGCACAAACAGGACTCAAAAGCAACTAGACATAAATGGTTCTTCAGATTCTTCCACACTGCCCAAATT
GGAAGAATTCTGTACCTCTCTTACCCAGTCAGAGCAGTCAGCAGACGGGAGCCAGTCTGAACCCAACAACAGTCAGACTCAGCCAAAGCA
AATTCAGCTTTCCACAGCAGCACCCTGTTCAACAACTGCAGTGGATGATTCCGCAGAAAAGCCCTCTGGTTCTGTGGAAAGCTCACCAGA
GATCCTAAAGAATGAAGATTTTTCTAGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGAT
TTTGTCTTATGAGTGCCAGATTTCTCAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTAC
ATCCAGGAGCCTCCTACACTGGTACCCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCG
CTTAGGCTTTGATGAACTCCCAGGCCAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACT
ATATGTTAGCTTTATTATGCTAACAGTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATT
CTGTGTCATTTTGTTCACCTTTGTTTTTAATGTAGTTTAAAGGAATTTGTTTTTTTGTGTTTGTTTTTCTTGTACATTATCATGACTGAT

>In-frame_ENST00000268182_ENST00000294848_TCGA-BR-A4PE-01A_IQGAP1_chr15_90969498_+_TDRD5_chr1_179620002_length(amino acids)=485AA_start in transcript=124_stop in transcript=1581
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVV
SLKKIYDREQTRYKEHWTSKAILQFQKLCGLKPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLA
LYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILDEIPTGMPCLESVTIGDDIWDENWLPLQAKMGKGGDAASHLFTASL
GGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQEKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSE
QSADGSQSEPNNSQTQPKQIQLSTAAPCSTTAVDDSAEKPSGSVESSPEILKNEDFSSSRAITLYKDKRQESVDQLSLILSYECQISQKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IQGAP1-TDRD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IQGAP1-TDRD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IQGAP1-TDRD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIQGAP1C0006118Brain Neoplasms1CTD_human
HgeneIQGAP1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneIQGAP1C0043094Weight Gain1CTD_human
HgeneIQGAP1C0153633Malignant neoplasm of brain1CTD_human
HgeneIQGAP1C0496899Benign neoplasm of brain, unspecified1CTD_human
HgeneIQGAP1C0750974Brain Tumor, Primary1CTD_human
HgeneIQGAP1C0750977Recurrent Brain Neoplasm1CTD_human
HgeneIQGAP1C0750979Primary malignant neoplasm of brain1CTD_human
HgeneIQGAP1C1527390Neoplasms, Intracranial1CTD_human
HgeneIQGAP1C2239176Liver carcinoma1CTD_human