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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ISG20-TBCC (FusionGDB2 ID:40128) |
Fusion Gene Summary for ISG20-TBCC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ISG20-TBCC | Fusion gene ID: 40128 | Hgene | Tgene | Gene symbol | ISG20 | TBCC | Gene ID | 3669 | 6903 |
| Gene name | interferon stimulated exonuclease gene 20 | tubulin folding cofactor C | |
| Synonyms | CD25|HEM45 | CFC | |
| Cytomap | 15q26.1 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interferon-stimulated gene 20 kDa proteinestrogen-regulated transcript 45 proteininterferon stimulated exonuclease gene 20kDapromyelocytic leukemia nuclear body-associated protein ISG20 | tubulin-specific chaperone C | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q96AZ6 | TBCCD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000560741, ENST00000306072, ENST00000379224, ENST00000560746, | ENST00000372876, ENST00000244625, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ISG20 [Title/Abstract] AND TBCC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ISG20(89182642)-TBCC(42713713), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ISG20-TBCC seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ISG20-TBCC seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ISG20 | GO:0000738 | DNA catabolic process, exonucleolytic | 11401564 |
| Hgene | ISG20 | GO:0006401 | RNA catabolic process | 11401564 |
| Hgene | ISG20 | GO:0009615 | response to virus | 12594219 |
| Tgene | TBCC | GO:0007023 | post-chaperonin tubulin folding pathway | 11847227 |
| Fusion gene breakpoints across ISG20 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across TBCC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BQ052721 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
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Fusion Gene ORF analysis for ISG20-TBCC |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000560741 | ENST00000372876 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| In-frame | ENST00000560741 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| Frame-shift | ENST00000306072 | ENST00000372876 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| In-frame | ENST00000306072 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| Frame-shift | ENST00000379224 | ENST00000372876 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| In-frame | ENST00000379224 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| intron-3CDS | ENST00000560746 | ENST00000372876 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| intron-3CDS | ENST00000560746 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000560741 | ISG20 | chr15 | 89182642 | + | ENST00000244625 | TBCC | chr6 | 42713713 | - | 1798 | 323 | 336 | 1265 | 309 |
| ENST00000306072 | ISG20 | chr15 | 89182642 | + | ENST00000244625 | TBCC | chr6 | 42713713 | - | 1992 | 517 | 530 | 1459 | 309 |
| ENST00000379224 | ISG20 | chr15 | 89182642 | + | ENST00000244625 | TBCC | chr6 | 42713713 | - | 1794 | 319 | 332 | 1261 | 309 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000560741 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - | 0.60843694 | 0.3915631 |
| ENST00000306072 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - | 0.4175398 | 0.58246017 |
| ENST00000379224 | ENST00000244625 | ISG20 | chr15 | 89182642 | + | TBCC | chr6 | 42713713 | - | 0.50274175 | 0.49725822 |
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Fusion Genomic Features for ISG20-TBCC |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ISG20-TBCC |
| Go to FGviewer for the breakpoints of chr15:89182642-chr6:42713713 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ISG20 | TBCC |
| FUNCTION: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. {ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:21036379}. | 557 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TBCC | chr15:89182642 | chr6:42713713 | ENST00000244625 | 0 | 2 | 171_323 | 0 | 347.0 | Domain | C-CAP/cofactor C-like | |
| Tgene | TBCC | chr15:89182642 | chr6:42713713 | ENST00000372876 | 0 | 1 | 171_323 | 0 | 347.0 | Domain | C-CAP/cofactor C-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ISG20-TBCC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000560741_ENST00000244625_BQ052721_ISG20_chr15_89182642_+_TBCC_chr6_42713713_length(transcript)=1798nt_BP=323nt TATGGTCATTACAGGTGGTCAGCTGTAGCTGGATGTGTGCCTTGAAAGGCTGACAAGTTTGCCCTGAGTGACTCACCTACTGTCACCTGA TCCAACAAGATTTGTGGGCGTAGCCTGCCGATGGGTGACGCCAGTTAAAGGGGCTGGGGCCCCACCGGGAGAGTGGCCTGGCTCGTTGCA GCCTCGTGAACGTCCACGGTGCTGTGCTGTACGACAAGTTCATCCGGCCTGAGGGAGAGATCACCGATTACAGAACCCGGGTCAGCGGGG TCACCCCTCAGCACATGGTGGGGGCCACACCATTTGCCGTGGCCAGGCTAGAGACAAGAACGGCAGCTGGAAGTTGAAAGGCGGAAACAA AAGCGGCAGAACCAGGAGGTAGAGAAGGAGAACAGCCACTTTTTCGTCGCCACCTTTGTTCGGGAGCGAGCGGCCGTGGAAGAGCTTCTG GAGCGCGCGGAGTCGGTCGAGCGGCTGGAGGAGGCGGCCTCTCGGCTCCAGGGGCTGCAGAAACTAATCAACGACTCAGTTTTTTTCCTA GCCGCTTACGACCTGCGGCAGGGACAAGAGGCGCTGGCGCGGCTGCAGGCGGCCTTGGCCGAGCGGCGCCGGGGGCTGCAGCCCAAGAAG CGTTTCGCTTTCAAGACCCGGGGAAAGGATGCTGCTTCGTCTACCAAAGTAGACGCGGCTCCTGGCATCCCCCCGGCAGTTGAAAGCATA CAGGACTCCCCGCTGCCCAAGAAGGCGGAAGGAGACCTCGGCCCCAGCTGGGTCTGCGGTTTCTCCAACCTGGAGTCCCAAGTCTTGGAG AAGAGAGCCAGCGAGTTGCACCAGCGCGACGTTCTTTTGACCGAACTGAGCAACTGCACGGTCAGACTGTATGGAAATCCCAACACCCTG CGGCTAACCAAGGCCCACAGCTGCAAGCTGCTCTGCGGTCCGGTGTCTACCTCTGTTTTCCTGGAGGACTGCAGTGACTGCGTGCTGGCA GTGGCCTGCCAACAGCTCCGCATACACAGTACGAAAGACACCCGCATCTTCCTGCAGGTGACCAGCAGGGCCATCGTGGAGGACTGCAGT GGGATCCAGTTCGCCCCTTACACCTGGAGCTACCCGGAGATCGACAAGGACTTCGAGAGCTCTGGTTTAGATAGGAGCAAAAATAACTGG AACGATGTTGACGATTTTAACTGGCTGGCCCGGGATATGGCCTCCCCAAACTGGAGTATTCTTCCTGAAGAGGAGCGAAATATCCAGTGG GACTAAGCAGTTGTCACTCTGTTCTTCACTCCTACCAAATACTTTCCACGTTGGACTTTCCCCCTTATTGGGTCTCGAAGTTTACTTATT GTCACACTGTGTATGTTTTCAGCATTTTAAGGCTAGAGATTGTAATGGGCTCCTACTTGTAATTTCCATTAAATTCGTAACAGGTATAAC ACTAAAGCATTTTTGCTATTTTCGTCATGCCTTTGAGACTGAGTCTTACTCCGTCCCCCAGCGTGGTGGCGCGCTGGGATTACAGGCGCG CGCCACCACGCGAACTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTGTCCGGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCAC CCGCTTCAGCTTCCCAAAGTGCTGGCATTACAGGCGTGAGCCACCACGCCAGGGCTTTATTTATTTATTTTTACCACAATAGTTTGAAGC >In-frame_ENST00000560741_ENST00000244625_BQ052721_ISG20_chr15_89182642_+_TBCC_chr6_42713713_length(amino acids)=309AA_start in transcript=336_stop in transcript=1265 MEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAER RRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVR LYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSG -------------------------------------------------------------- >In-frame_ENST00000306072_ENST00000244625_BQ052721_ISG20_chr15_89182642_+_TBCC_chr6_42713713_length(transcript)=1992nt_BP=517nt ATCCACTCCACGAACGTCAAATGCGTCATCTGAGGAGGGGGAGGGCCGGGGCAAAGGAGGGGCACCCTGACATGGAGCCTGCCAGCTCCG TCAGCCCTGACTCGGCCCGGAGCTGAGCTCCCCACCTGCCGGTAGCCCAGGAGATGGAGCAGCCCAGCCCACGTGCCCGGCCTTCCGCCC CTGACTTCACTTGATAACAAACTAGAAACTGAAACAGGGTCGGGATGCCGATGCCGGCTTGGAGTTAGAGATGAGTCACCGCTGAGAGCA GCTGCAGTAGCTGAGCAGTGGCAGCAGAGAGGCAGACGTGAGCTGAGGGCGCAGAGGCAGGCAGGGGCTGGGGCCCCACCGGGAGAGTGG CCTGGCTCGTTGCAGCCTCGTGAACGTCCACGGTGCTGTGCTGTACGACAAGTTCATCCGGCCTGAGGGAGAGATCACCGATTACAGAAC CCGGGTCAGCGGGGTCACCCCTCAGCACATGGTGGGGGCCACACCATTTGCCGTGGCCAGGCTAGAGACAAGAACGGCAGCTGGAAGTTG AAAGGCGGAAACAAAAGCGGCAGAACCAGGAGGTAGAGAAGGAGAACAGCCACTTTTTCGTCGCCACCTTTGTTCGGGAGCGAGCGGCCG TGGAAGAGCTTCTGGAGCGCGCGGAGTCGGTCGAGCGGCTGGAGGAGGCGGCCTCTCGGCTCCAGGGGCTGCAGAAACTAATCAACGACT CAGTTTTTTTCCTAGCCGCTTACGACCTGCGGCAGGGACAAGAGGCGCTGGCGCGGCTGCAGGCGGCCTTGGCCGAGCGGCGCCGGGGGC TGCAGCCCAAGAAGCGTTTCGCTTTCAAGACCCGGGGAAAGGATGCTGCTTCGTCTACCAAAGTAGACGCGGCTCCTGGCATCCCCCCGG CAGTTGAAAGCATACAGGACTCCCCGCTGCCCAAGAAGGCGGAAGGAGACCTCGGCCCCAGCTGGGTCTGCGGTTTCTCCAACCTGGAGT CCCAAGTCTTGGAGAAGAGAGCCAGCGAGTTGCACCAGCGCGACGTTCTTTTGACCGAACTGAGCAACTGCACGGTCAGACTGTATGGAA ATCCCAACACCCTGCGGCTAACCAAGGCCCACAGCTGCAAGCTGCTCTGCGGTCCGGTGTCTACCTCTGTTTTCCTGGAGGACTGCAGTG ACTGCGTGCTGGCAGTGGCCTGCCAACAGCTCCGCATACACAGTACGAAAGACACCCGCATCTTCCTGCAGGTGACCAGCAGGGCCATCG TGGAGGACTGCAGTGGGATCCAGTTCGCCCCTTACACCTGGAGCTACCCGGAGATCGACAAGGACTTCGAGAGCTCTGGTTTAGATAGGA GCAAAAATAACTGGAACGATGTTGACGATTTTAACTGGCTGGCCCGGGATATGGCCTCCCCAAACTGGAGTATTCTTCCTGAAGAGGAGC GAAATATCCAGTGGGACTAAGCAGTTGTCACTCTGTTCTTCACTCCTACCAAATACTTTCCACGTTGGACTTTCCCCCTTATTGGGTCTC GAAGTTTACTTATTGTCACACTGTGTATGTTTTCAGCATTTTAAGGCTAGAGATTGTAATGGGCTCCTACTTGTAATTTCCATTAAATTC GTAACAGGTATAACACTAAAGCATTTTTGCTATTTTCGTCATGCCTTTGAGACTGAGTCTTACTCCGTCCCCCAGCGTGGTGGCGCGCTG GGATTACAGGCGCGCGCCACCACGCGAACTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTGTCCGGGCTGCTCTCGAACTCCTGAC CTCAGGTGATCCACCCGCTTCAGCTTCCCAAAGTGCTGGCATTACAGGCGTGAGCCACCACGCCAGGGCTTTATTTATTTATTTTTACCA CAATAGTTTGAAGCAGTAAGGGGGAAGGAGGGTGATTATATTGCTTTGTAATGGTTTGTGATACTTGAAACATCACGGTGCATAATAAAG >In-frame_ENST00000306072_ENST00000244625_BQ052721_ISG20_chr15_89182642_+_TBCC_chr6_42713713_length(amino acids)=309AA_start in transcript=530_stop in transcript=1459 MEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAER RRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVR LYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSG -------------------------------------------------------------- >In-frame_ENST00000379224_ENST00000244625_BQ052721_ISG20_chr15_89182642_+_TBCC_chr6_42713713_length(transcript)=1794nt_BP=319nt AAACTAGAAACTGAAACAGGGTCGGGATGCCGATGCCGGCTTGGAGTTAGAGATGAGTCACCGCTGAGAGCAGCTGCAGTAGCTGAGCAG TGGCAGCAGAGAGGCAGACGTGAGCTGAGGGCGCAGAGGCAGGCAGGGGCTGGGGCCCCACCGGGAGAGTGGCCTGGCTCGTTGCAGCCT CGTGAACGTCCACGGTGCTGTGCTGTACGACAAGTTCATCCGGCCTGAGGGAGAGATCACCGATTACAGAACCCGGGTCAGCGGGGTCAC CCCTCAGCACATGGTGGGGGCCACACCATTTGCCGTGGCCAGGCTAGAGACAAGAACGGCAGCTGGAAGTTGAAAGGCGGAAACAAAAGC GGCAGAACCAGGAGGTAGAGAAGGAGAACAGCCACTTTTTCGTCGCCACCTTTGTTCGGGAGCGAGCGGCCGTGGAAGAGCTTCTGGAGC GCGCGGAGTCGGTCGAGCGGCTGGAGGAGGCGGCCTCTCGGCTCCAGGGGCTGCAGAAACTAATCAACGACTCAGTTTTTTTCCTAGCCG CTTACGACCTGCGGCAGGGACAAGAGGCGCTGGCGCGGCTGCAGGCGGCCTTGGCCGAGCGGCGCCGGGGGCTGCAGCCCAAGAAGCGTT TCGCTTTCAAGACCCGGGGAAAGGATGCTGCTTCGTCTACCAAAGTAGACGCGGCTCCTGGCATCCCCCCGGCAGTTGAAAGCATACAGG ACTCCCCGCTGCCCAAGAAGGCGGAAGGAGACCTCGGCCCCAGCTGGGTCTGCGGTTTCTCCAACCTGGAGTCCCAAGTCTTGGAGAAGA GAGCCAGCGAGTTGCACCAGCGCGACGTTCTTTTGACCGAACTGAGCAACTGCACGGTCAGACTGTATGGAAATCCCAACACCCTGCGGC TAACCAAGGCCCACAGCTGCAAGCTGCTCTGCGGTCCGGTGTCTACCTCTGTTTTCCTGGAGGACTGCAGTGACTGCGTGCTGGCAGTGG CCTGCCAACAGCTCCGCATACACAGTACGAAAGACACCCGCATCTTCCTGCAGGTGACCAGCAGGGCCATCGTGGAGGACTGCAGTGGGA TCCAGTTCGCCCCTTACACCTGGAGCTACCCGGAGATCGACAAGGACTTCGAGAGCTCTGGTTTAGATAGGAGCAAAAATAACTGGAACG ATGTTGACGATTTTAACTGGCTGGCCCGGGATATGGCCTCCCCAAACTGGAGTATTCTTCCTGAAGAGGAGCGAAATATCCAGTGGGACT AAGCAGTTGTCACTCTGTTCTTCACTCCTACCAAATACTTTCCACGTTGGACTTTCCCCCTTATTGGGTCTCGAAGTTTACTTATTGTCA CACTGTGTATGTTTTCAGCATTTTAAGGCTAGAGATTGTAATGGGCTCCTACTTGTAATTTCCATTAAATTCGTAACAGGTATAACACTA AAGCATTTTTGCTATTTTCGTCATGCCTTTGAGACTGAGTCTTACTCCGTCCCCCAGCGTGGTGGCGCGCTGGGATTACAGGCGCGCGCC ACCACGCGAACTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTGTCCGGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCCGC TTCAGCTTCCCAAAGTGCTGGCATTACAGGCGTGAGCCACCACGCCAGGGCTTTATTTATTTATTTTTACCACAATAGTTTGAAGCAGTA >In-frame_ENST00000379224_ENST00000244625_BQ052721_ISG20_chr15_89182642_+_TBCC_chr6_42713713_length(amino acids)=309AA_start in transcript=332_stop in transcript=1261 MEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAER RRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVR LYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ISG20-TBCC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ISG20-TBCC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ISG20-TBCC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ISG20 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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