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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGA4-UBE2E3 (FusionGDB2 ID:40257)

Fusion Gene Summary for ITGA4-UBE2E3

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGA4-UBE2E3
Fusion gene ID: 40257
HgeneTgene
Gene symbol

ITGA4

UBE2E3

Gene ID

3676

10477

Gene nameintegrin subunit alpha 4ubiquitin conjugating enzyme E2 E3
SynonymsCD49D|IA4UBCH9|UbcM2
Cytomap

2q31.3

2q31.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-4269C wild typeCD49 antigen-like family member DVLA-4 subunit alphaalpha 4 subunit of VLA-4 receptorantigen CD49D, alpha-4 subunit of VLA-4 receptorintegrin alpha-IVvery late activation protein 4 receptor, alpha 4 subunitubiquitin-conjugating enzyme E2 E3E2 ubiquitin-conjugating enzyme E3ubiquitin carrier protein E3ubiquitin conjugating enzyme E2E 3ubiquitin-conjugating enzyme E2-23 kDaubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)ubiquitin-conjugating e
Modification date2020031320200313
UniProtAcc

P13612

.
Ensembl transtripts involved in fusion geneENST00000339307, ENST00000397033, 
ENST00000478440, 		ENST00000392415, 
ENST00000410062, ENST00000602710, 
ENST00000602837, ENST00000602959, 
ENST00000602475, ENST00000602632, 
Fusion gene scores* DoF score6 X 5 X 4=12012 X 11 X 6=792
# samples 613
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGA4 [Title/Abstract] AND UBE2E3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGA4(182347378)-UBE2E3(181925392), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGA4

GO:0007159

leukocyte cell-cell adhesion

1715889

HgeneITGA4

GO:0090074

negative regulation of protein homodimerization activity

12869515

TgeneUBE2E3

GO:0070534

protein K63-linked ubiquitination

20061386

TgeneUBE2E3

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2E3

GO:0070979

protein K11-linked ubiquitination

20061386


check buttonFusion gene breakpoints across ITGA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBE2E3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C3-01AITGA4chr2

182347378

+UBE2E3chr2

181925392

+


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Fusion Gene ORF analysis for ITGA4-UBE2E3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000339307ENST00000392415ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3CDSENST00000339307ENST00000410062ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3CDSENST00000339307ENST00000602710ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3UTRENST00000339307ENST00000602837ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3UTRENST00000339307ENST00000602959ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-intronENST00000339307ENST00000602475ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-intronENST00000339307ENST00000602632ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
In-frameENST00000397033ENST00000392415ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
In-frameENST00000397033ENST00000410062ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
In-frameENST00000397033ENST00000602710ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
5CDS-3UTRENST00000397033ENST00000602837ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
5CDS-3UTRENST00000397033ENST00000602959ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
5CDS-intronENST00000397033ENST00000602475ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
5CDS-intronENST00000397033ENST00000602632ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3CDSENST00000478440ENST00000392415ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3CDSENST00000478440ENST00000410062ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3CDSENST00000478440ENST00000602710ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3UTRENST00000478440ENST00000602837ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-3UTRENST00000478440ENST00000602959ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-intronENST00000478440ENST00000602475ITGA4chr2

182347378

+UBE2E3chr2

181925392

+
intron-intronENST00000478440ENST00000602632ITGA4chr2

182347378

+UBE2E3chr2

181925392

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397033ITGA4chr2182347378+ENST00000392415UBE2E3chr2181925392+22521471131716567
ENST00000397033ITGA4chr2182347378+ENST00000410062UBE2E3chr2181925392+22701471131716567
ENST00000397033ITGA4chr2182347378+ENST00000602710UBE2E3chr2181925392+22701471131716567

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397033ENST00000392415ITGA4chr2182347378+UBE2E3chr2181925392+0.0006968460.9993031
ENST00000397033ENST00000410062ITGA4chr2182347378+UBE2E3chr2181925392+0.00066790.99933213
ENST00000397033ENST00000602710ITGA4chr2182347378+UBE2E3chr2181925392+0.00066790.99933213

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Fusion Genomic Features for ITGA4-UBE2E3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITGA4chr2182347378+UBE2E3chr2181925391+1.79E-050.9999821
ITGA4chr2182347378+UBE2E3chr2181925391+1.79E-050.9999821

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITGA4-UBE2E3


check button Go to

FGviewer for the breakpoints of chr2:182347378-chr2:181925392

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA4

P13612

.
FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928314_322347.01033.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928110_177347.01033.0RepeatFG-GAP 2
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928185_237347.01033.0RepeatFG-GAP 3
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928238_291347.01033.0RepeatFG-GAP 4
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+92835_100347.01033.0RepeatFG-GAP 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928377_385347.01033.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928439_447347.01033.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+9281003_1007347.01033.0MotifNote=GFFKR motif
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928606_616347.01033.0MotifNote=SG1
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928292_351347.01033.0RepeatFG-GAP 5
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928355_412347.01033.0RepeatFG-GAP 6
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928416_478347.01033.0RepeatFG-GAP 7
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+9281002_1032347.01033.0Topological domainCytoplasmic
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+92835_977347.01033.0Topological domainExtracellular
HgeneITGA4chr2:182347378chr2:181925392ENST00000397033+928978_1001347.01033.0TransmembraneHelical
TgeneUBE2E3chr2:182347378chr2:181925392ENST000003924153661_207126.0208.0DomainUBC core
TgeneUBE2E3chr2:182347378chr2:181925392ENST000004100623661_207126.0208.0DomainUBC core
TgeneUBE2E3chr2:182347378chr2:181925392ENST000006027103661_207126.0208.0DomainUBC core
TgeneUBE2E3chr2:182347378chr2:181925392ENST000006029594761_207126.0208.0DomainUBC core


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Fusion Gene Sequence for ITGA4-UBE2E3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000397033_ENST00000392415_TCGA-X6-A8C3-01A_ITGA4_chr2_182347378_+_UBE2E3_chr2_181925392_length(transcript)=2252nt_BP=1471nt
GCCATCCCGCGCTCTGCGGGCTGGGAGGCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCGCGT
AGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGCGGCCCGTACCCGGAGAAGCAGCGCGAGCACCCG
AAGCTCCCGGCTGGCGGCAGAAACCGGGAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGGGCC
GACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGG
CCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCG
CGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGA
CACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCT
CCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCC
CGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTT
GGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGA
AAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTA
TGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG
ATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATT
TGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCA
GATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGG
AGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGG
AAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGTCAGGGAGTCATCTGTCT
GGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGC
GGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAGTGGACCAAGAGATACGC
AACATAATTCACATAATTTGTATGCAGTGTGAAGGAGCAGAAGGCATCTTCTCACTGTGCTGCAAATCTTTATAGCCTTTACAATACGGA
CTTCTGTGTATATGTTATACTGATTCTACTCTGCTTTTATCCTTTGGAGCCTGGGAGACTCCCCAAAAAGGTAAATGCTATCAAGAGTAG
AACTTTGTAGCTGTAGATTAGTTATGTTTAAAACGCCTACTTGCAAGTCTTGCTTCTTTGGGATATCAAAATGTATTTTGTGATGTACTA
AGGATACTGGTCCTGAAGTCTACCAAATATTATAGTGCATTTTAGCCTAATTCATTATCTGTATGAAGTTATAAAAGTAGCTGTAGATGG
CTAGGAATTATGTCATTTGTATTAAACCCAGATCTATTTCTGAGTATGTGGTTCATGCTGTTGTGAAAAATGTTTTACCTTTTACCTTTG
TCAGTTTGTAATGAGAGGATTTCCTTTTACCCTTTGTAGCTCAGAGAGCACCTGATGTATCATCTCAAACACAATAAACATGCTCCTGAA

>In-frame_ENST00000397033_ENST00000392415_TCGA-X6-A8C3-01A_ITGA4_chr2_182347378_+_UBE2E3_chr2_181925392_length(amino acids)=567AA_start in transcript=13_stop in transcript=1716
MRAGRPGPGRESCAAEVPQRPLQPRVGRDGARPCASAPRPGPHPAARTRRSSASTRSSRLAAETGSGAGRVRGIPGRPERSARGGPTSPP
LPSLLPLARWRRTRCASSLGAFFPVGQPSHPVQLWGSGRLVLNVPHRERMAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESA
LLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTL
SRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYW
TGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVC
AVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV

--------------------------------------------------------------
>In-frame_ENST00000397033_ENST00000410062_TCGA-X6-A8C3-01A_ITGA4_chr2_182347378_+_UBE2E3_chr2_181925392_length(transcript)=2270nt_BP=1471nt
GCCATCCCGCGCTCTGCGGGCTGGGAGGCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCGCGT
AGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGCGGCCCGTACCCGGAGAAGCAGCGCGAGCACCCG
AAGCTCCCGGCTGGCGGCAGAAACCGGGAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGGGCC
GACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGG
CCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCG
CGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGA
CACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCT
CCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCC
CGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTT
GGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGA
AAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTA
TGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG
ATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATT
TGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCA
GATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGG
AGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGG
AAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGTCAGGGAGTCATCTGTCT
GGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGC
GGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAGTGGACCAAGAGATACGC
AACATAATTCACATAATTTGTATGCAGTGTGAAGGAGCAGAAGGCATCTTCTCACTGTGCTGCAAATCTTTATAGCCTTTACAATACGGA
CTTCTGTGTATATGTTATACTGATTCTACTCTGCTTTTATCCTTTGGAGCCTGGGAGACTCCCCAAAAAGGTAAATGCTATCAAGAGTAG
AACTTTGTAGCTGTAGATTAGTTATGTTTAAAACGCCTACTTGCAAGTCTTGCTTCTTTGGGATATCAAAATGTATTTTGTGATGTACTA
AGGATACTGGTCCTGAAGTCTACCAAATATTATAGTGCATTTTAGCCTAATTCATTATCTGTATGAAGTTATAAAAGTAGCTGTAGATGG
CTAGGAATTATGTCATTTGTATTAAACCCAGATCTATTTCTGAGTATGTGGTTCATGCTGTTGTGAAAAATGTTTTACCTTTTACCTTTG
TCAGTTTGTAATGAGAGGATTTCCTTTTACCCTTTGTAGCTCAGAGAGCACCTGATGTATCATCTCAAACACAATAAACATGCTCCTGAA

>In-frame_ENST00000397033_ENST00000410062_TCGA-X6-A8C3-01A_ITGA4_chr2_182347378_+_UBE2E3_chr2_181925392_length(amino acids)=567AA_start in transcript=13_stop in transcript=1716
MRAGRPGPGRESCAAEVPQRPLQPRVGRDGARPCASAPRPGPHPAARTRRSSASTRSSRLAAETGSGAGRVRGIPGRPERSARGGPTSPP
LPSLLPLARWRRTRCASSLGAFFPVGQPSHPVQLWGSGRLVLNVPHRERMAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESA
LLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTL
SRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYW
TGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVC
AVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV

--------------------------------------------------------------
>In-frame_ENST00000397033_ENST00000602710_TCGA-X6-A8C3-01A_ITGA4_chr2_182347378_+_UBE2E3_chr2_181925392_length(transcript)=2270nt_BP=1471nt
GCCATCCCGCGCTCTGCGGGCTGGGAGGCCCGGGCCAGGACGCGAGTCCTGCGCAGCCGAGGTTCCCCAGCGCCCCCTGCAGCCGCGCGT
AGGCAGAGACGGAGCCCGGCCCTGCGCCTCCGCACCACGCCCGGGACCCCACCCAGCGGCCCGTACCCGGAGAAGCAGCGCGAGCACCCG
AAGCTCCCGGCTGGCGGCAGAAACCGGGAGTGGGGCCGGGCGAGTGCGCGGCATCCCAGGCCGGCCCGAACGCTCCGCCCGCGGTGGGCC
GACTTCCCCTCCTCTTCCCTCTCTCCTTCCTTTAGCCCGCTGGCGCCGGACACGCTGCGCCTCATCTCTTGGGGCGTTCTTCCCCGTTGG
CCAACCGTCGCATCCCGTGCAACTTTGGGGTAGTGGCCGTTTAGTGTTGAATGTTCCCCACCGAGAGCGCATGGCTTGGGAAGCGAGGCG
CGAACCCGGCCCCCGAAGGGCCGCCGTCCGGGAGACGGTGATGCTGTTGCTGTGCCTGGGGGTCCCGACCGGCCGCCCCTACAACGTGGA
CACTGAGAGCGCGCTGCTTTACCAGGGCCCCCACAACACGCTGTTCGGCTACTCGGTCGTGCTGCACAGCCACGGGGCGAACCGATGGCT
CCTAGTGGGTGCGCCCACTGCCAACTGGCTCGCCAACGCTTCAGTGATCAATCCCGGGGCGATTTACAGATGCAGGATCGGAAAGAATCC
CGGCCAGACGTGCGAACAGCTCCAGCTGGGTAGCCCTAATGGAGAACCTTGTGGAAAGACTTGTTTGGAAGAGAGAGACAATCAGTGGTT
GGGGGTCACACTTTCCAGACAGCCAGGAGAAAATGGATCCATCGTGACTTGTGGGCATAGATGGAAAAATATATTTTACATAAAGAATGA
AAATAAGCTCCCCACTGGTGGTTGCTATGGAGTGCCCCCTGATTTACGAACAGAACTGAGTAAAAGAATAGCTCCGTGTTATCAAGATTA
TGTGAAAAAATTTGGAGAAAATTTTGCATCATGTCAAGCTGGAATATCCAGTTTTTACACAAAGGATTTAATTGTGATGGGGGCCCCAGG
ATCATCTTACTGGACTGGCTCTCTTTTTGTCTACAATATAACTACAAATAAATACAAGGCTTTTTTAGACAAACAAAATCAAGTAAAATT
TGGAAGTTATTTAGGATATTCAGTCGGAGCTGGTCATTTTCGGAGCCAGCATACTACCGAAGTAGTCGGAGGAGCTCCTCAACATGAGCA
GATTGGTAAGGCATATATATTCAGCATTGATGAAAAAGAACTAAATATCTTACATGAAATGAAAGGTAAAAAGCTTGGATCGTACTTTGG
AGCTTCTGTCTGTGCTGTGGACCTCAATGCAGATGGCTTCTCAGATCTGCTCGTGGGAGCACCCATGCAGAGCACCATCAGAGAGGAAGG
AAGAGTGTTTGTGTACATCAACTCTGGCTCGGTTACTTTCCGCACCAGAATCTATCACTGCAACATCAACAGTCAGGGAGTCATCTGTCT
GGACATCCTTAAAGACAACTGGAGTCCCGCTTTGACTATTTCAAAGGTTTTGCTGTCTATTTGTTCCCTTTTGACAGACTGCAACCCTGC
GGATCCTCTGGTTGGAAGCATAGCCACTCAGTATTTGACCAACAGAGCAGAACACGACAGGATAGCCAGACAGTGGACCAAGAGATACGC
AACATAATTCACATAATTTGTATGCAGTGTGAAGGAGCAGAAGGCATCTTCTCACTGTGCTGCAAATCTTTATAGCCTTTACAATACGGA
CTTCTGTGTATATGTTATACTGATTCTACTCTGCTTTTATCCTTTGGAGCCTGGGAGACTCCCCAAAAAGGTAAATGCTATCAAGAGTAG
AACTTTGTAGCTGTAGATTAGTTATGTTTAAAACGCCTACTTGCAAGTCTTGCTTCTTTGGGATATCAAAATGTATTTTGTGATGTACTA
AGGATACTGGTCCTGAAGTCTACCAAATATTATAGTGCATTTTAGCCTAATTCATTATCTGTATGAAGTTATAAAAGTAGCTGTAGATGG
CTAGGAATTATGTCATTTGTATTAAACCCAGATCTATTTCTGAGTATGTGGTTCATGCTGTTGTGAAAAATGTTTTACCTTTTACCTTTG
TCAGTTTGTAATGAGAGGATTTCCTTTTACCCTTTGTAGCTCAGAGAGCACCTGATGTATCATCTCAAACACAATAAACATGCTCCTGAA

>In-frame_ENST00000397033_ENST00000602710_TCGA-X6-A8C3-01A_ITGA4_chr2_182347378_+_UBE2E3_chr2_181925392_length(amino acids)=567AA_start in transcript=13_stop in transcript=1716
MRAGRPGPGRESCAAEVPQRPLQPRVGRDGARPCASAPRPGPHPAARTRRSSASTRSSRLAAETGSGAGRVRGIPGRPERSARGGPTSPP
LPSLLPLARWRRTRCASSLGAFFPVGQPSHPVQLWGSGRLVLNVPHRERMAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESA
LLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTL
SRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYW
TGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVC
AVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV

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Fusion Gene PPI Analysis for ITGA4-UBE2E3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGA4-UBE2E3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneITGA4P13612DB06822TinzaparinInhibitorSmall moleculeApproved
HgeneITGA4P13612DB06822TinzaparinInhibitorSmall moleculeApproved
HgeneITGA4P13612DB09033VedolizumabAntibodyBiotechApproved
HgeneITGA4P13612DB09033VedolizumabAntibodyBiotechApproved
HgeneITGA4P13612DB00108NatalizumabAntibodyBiotechApproved|Investigational
HgeneITGA4P13612DB00108NatalizumabAntibodyBiotechApproved|Investigational

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Related Diseases for ITGA4-UBE2E3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGA4C0004352Autistic Disorder1CTD_human
HgeneITGA4C0017639Gliosis1CTD_human
HgeneITGA4C0021390Inflammatory Bowel Diseases1CTD_human
HgeneITGA4C0023434Chronic Lymphocytic Leukemia1CTD_human
HgeneITGA4C3887640Astrocytosis1CTD_human