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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGB1-TAX1BP1 (FusionGDB2 ID:40336)

Fusion Gene Summary for ITGB1-TAX1BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB1-TAX1BP1
Fusion gene ID: 40336
HgeneTgene
Gene symbol

ITGB1

TAX1BP1

Gene ID

3688

8887

Gene nameintegrin subunit beta 1Tax1 binding protein 1
SynonymsCD29|FNRB|GPIIA|MDF2|MSK12|VLA-BETA|VLABCALCOCO3|T6BP|TXBP151
Cytomap

10p11.22

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-1glycoprotein IIaintegrin VLA-4 beta subunitintegrin beta 1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)very late activation protein, beta polypeptidetax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1
Modification date2020031320200327
UniProtAcc

P05556

.
Ensembl transtripts involved in fusion geneENST00000423113, ENST00000396033, 
ENST00000302278, ENST00000374956, 
ENST00000484088, 		ENST00000543117, 
ENST00000265393, ENST00000409980, 
ENST00000433216, ENST00000396319, 
ENST00000494033, 
Fusion gene scores* DoF score10 X 7 X 8=56022 X 14 X 9=2772
# samples 1126
** MAII scorelog2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/2772*10)=-3.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB1 [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB1(33197295)-TAX1BP1(27867356), # samples:1
Anticipated loss of major functional domain due to fusion event.ITGB1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ITGB1-TAX1BP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ITGB1-TAX1BP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB1

GO:0007155

cell adhesion

19703720

HgeneITGB1

GO:0007159

leukocyte cell-cell adhesion

1715889

HgeneITGB1

GO:0007229

integrin-mediated signaling pathway

31331973

HgeneITGB1

GO:0010710

regulation of collagen catabolic process

10455171

HgeneITGB1

GO:0010763

positive regulation of fibroblast migration

26763945

HgeneITGB1

GO:0023035

CD40 signaling pathway

31331973

HgeneITGB1

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneITGB1

GO:0051897

positive regulation of protein kinase B signaling

24044949

HgeneITGB1

GO:0090303

positive regulation of wound healing

26763945

HgeneITGB1

GO:1903078

positive regulation of protein localization to plasma membrane

10455171

HgeneITGB1

GO:2000273

positive regulation of signaling receptor activity

24044949


check buttonFusion gene breakpoints across ITGB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TAX1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8679ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+


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Fusion Gene ORF analysis for ITGB1-TAX1BP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000423113ENST00000543117ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000423113ENST00000265393ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000423113ENST00000409980ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000423113ENST00000433216ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000423113ENST00000396319ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
5CDS-intronENST00000423113ENST00000494033ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
In-frameENST00000396033ENST00000543117ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
In-frameENST00000396033ENST00000265393ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
In-frameENST00000396033ENST00000409980ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
In-frameENST00000396033ENST00000433216ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
In-frameENST00000396033ENST00000396319ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
5CDS-intronENST00000396033ENST00000494033ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000302278ENST00000543117ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000302278ENST00000265393ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000302278ENST00000409980ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000302278ENST00000433216ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000302278ENST00000396319ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
5CDS-intronENST00000302278ENST00000494033ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000374956ENST00000543117ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000374956ENST00000265393ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000374956ENST00000409980ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000374956ENST00000433216ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
Frame-shiftENST00000374956ENST00000396319ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
5CDS-intronENST00000374956ENST00000494033ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
intron-3CDSENST00000484088ENST00000543117ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
intron-3CDSENST00000484088ENST00000265393ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
intron-3CDSENST00000484088ENST00000409980ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
intron-3CDSENST00000484088ENST00000433216ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
intron-3CDSENST00000484088ENST00000396319ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+
intron-intronENST00000484088ENST00000494033ITGB1chr10

33197295

-TAX1BP1chr7

27867356

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396033ITGB1chr1033197295-ENST00000543117TAX1BP1chr727867356+30162467402751903
ENST00000396033ITGB1chr1033197295-ENST00000265393TAX1BP1chr727867356+28042467402751903
ENST00000396033ITGB1chr1033197295-ENST00000409980TAX1BP1chr727867356+28042467402751903
ENST00000396033ITGB1chr1033197295-ENST00000433216TAX1BP1chr727867356+27872467402751903
ENST00000396033ITGB1chr1033197295-ENST00000396319TAX1BP1chr727867356+31842467402751903

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396033ENST00000543117ITGB1chr1033197295-TAX1BP1chr727867356+0.0001106430.9998894
ENST00000396033ENST00000265393ITGB1chr1033197295-TAX1BP1chr727867356+0.0001350360.99986494
ENST00000396033ENST00000409980ITGB1chr1033197295-TAX1BP1chr727867356+0.0001350360.99986494
ENST00000396033ENST00000433216ITGB1chr1033197295-TAX1BP1chr727867356+0.0001433810.9998566
ENST00000396033ENST00000396319ITGB1chr1033197295-TAX1BP1chr727867356+0.000102980.999897

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Fusion Genomic Features for ITGB1-TAX1BP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITGB1chr1033197295-TAX1BP1chr727867356+0.0035902920.9964097
ITGB1chr1033197295-TAX1BP1chr727867356+0.0035902920.9964097

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITGB1-TAX1BP1


check button Go to

FGviewer for the breakpoints of chr10:33197295-chr7:27867356

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB1

P05556

.
FUNCTION: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). {ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:7523423}.; FUNCTION: [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). {ECO:0000305|PubMed:2249781}.; FUNCTION: [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250|UniProtKB:P09055}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.; FUNCTION: (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:20660204}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. {ECO:0000269|PubMed:17945327}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus. {ECO:0000269|PubMed:16501085}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516140_378777.0799.0DomainNote=VWFA
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517140_378777.0826.0DomainNote=VWFA
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516140_378777.0799.0DomainNote=VWFA
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416140_378777.01217.0DomainNote=VWFA
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516295_314777.0799.0RegionCX3CL1-binding
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516466_635777.0799.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517295_314777.0826.0RegionCX3CL1-binding
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517466_635777.0826.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516295_314777.0799.0RegionCX3CL1-binding
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516466_635777.0799.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416295_314777.01217.0RegionCX3CL1-binding
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416466_635777.01217.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516466_515777.0799.0RepeatNote=I
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516516_559777.0799.0RepeatNote=II
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516560_598777.0799.0RepeatNote=III
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516599_635777.0799.0RepeatNote=IV
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517466_515777.0826.0RepeatNote=I
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517516_559777.0826.0RepeatNote=II
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517560_598777.0826.0RepeatNote=III
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517599_635777.0826.0RepeatNote=IV
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516466_515777.0799.0RepeatNote=I
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516516_559777.0799.0RepeatNote=II
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516560_598777.0799.0RepeatNote=III
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516599_635777.0799.0RepeatNote=IV
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416466_515777.01217.0RepeatNote=I
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416516_559777.01217.0RepeatNote=II
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416560_598777.01217.0RepeatNote=III
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416599_635777.01217.0RepeatNote=IV
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-151621_728777.0799.0Topological domainExtracellular
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-151721_728777.0826.0Topological domainExtracellular
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-151621_728777.0799.0Topological domainExtracellular
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-141621_728777.01217.0Topological domainExtracellular
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516729_751777.0799.0TransmembraneHelical
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517729_751777.0826.0TransmembraneHelical
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516729_751777.0799.0TransmembraneHelical
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416729_751777.01217.0TransmembraneHelical
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000002653931417727_753653.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000002653931417754_780653.0748.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000003963191417727_753695.0790.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000003963191417754_780695.0790.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000004332161316727_753496.0591.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000004332161316754_780496.0591.0Zinc fingerUBZ1-type 2
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000005431171417727_753653.0748.0Zinc fingerUBZ1-type 1
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000005431171417754_780653.0748.0Zinc fingerUBZ1-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516752_798777.0799.0Topological domainCytoplasmic
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517752_798777.0826.0Topological domainCytoplasmic
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516752_798777.0799.0Topological domainCytoplasmic
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416752_798777.01217.0Topological domainCytoplasmic
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000002653931417144_599653.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000003963191417144_599695.0790.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000004332161316144_599496.0591.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000005431171417144_599653.0748.0Coiled coilOntology_term=ECO:0000255
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000002653931417320_420653.0748.0RegionNote=Oligomerization
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000003963191417320_420695.0790.0RegionNote=Oligomerization
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000004332161316320_420496.0591.0RegionNote=Oligomerization
TgeneTAX1BP1chr10:33197295chr7:27867356ENST000005431171417320_420653.0748.0RegionNote=Oligomerization


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Fusion Gene Sequence for ITGB1-TAX1BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000396033_ENST00000543117_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(transcript)=3016nt_BP=2467nt
GAGCCAGCCCAGCCGCGTTCCGAACGTGAGGGTCGCCGGCCTGGGCGCTGTCACGTCGGGGCTGCCGGAGCTGCGGGGGACCGGGCCCGA
ACGGCCCCTGACACCTGCGGTCTCCCGCCGGGCTGGGCAAGCGCAGATGAATTTACAACCAATTTTCTGGATTGGACTGATCAGTTCAGT
TTGCTGTGTGTTTGCTCAAACAGATGAAAATAGATGTTTAAAAGCAAATGCCAAATCATGTGGAGAATGTATACAAGCAGGGCCAAATTG
TGGGTGGTGCACAAATTCAACATTTTTACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCCTTAAAAAAGAAGGGTTG
CCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATAAAGAAAAATAAAAATGTAACCAACCGTAGCAAAGGAACAGCAGAGAA
GCTCAAGCCAGAGGATATTACTCAGATCCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAGACATTTACATTAAAATT
CAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATGGACCTGTCTTACTCAATGAAAGACGATTTGGAGAATGTAAAAAGTCT
TGGAACAGATCTGATGAATGAAATGAGGAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAAAAGACTGTGATGCCTTA
CATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGTGAACAGAACTGCACCAGCCCATTTAGCTACAAAAATGTGCTCAGTCT
TACTAATAAAGGAGAAGTATTTAATGAACTTGTTGGAAAACAGCGCATATCTGGAAATTTGGATTCTCCAGAAGGTGGTTTCGATGCCAT
CATGCAAGTTGCAGTTTGTGGATCACTGATTGGCTGGAGGAATGTTACACGGCTGCTGGTGTTTTCCACAGATGCCGGGTTTCACTTTGC
TGGAGATGGGAAACTTGGTGGCATTGTTTTACCAAATGATGGACAATGTCACCTGGAAAATAATATGTACACAATGAGCCATTATTATGA
TTATCCTTCTATTGCTCACCTTGTCCAGAAACTGAGTGAAAATAATATTCAGACAATTTTTGCAGTTACTGAAGAATTTCAGCCTGTTTA
CAAGGAGCTGAAAAACTTGATCCCTAAGTCAGCAGTAGGAACATTATCTGCAAATTCTAGCAATGTAATTCAGTTGATCATTGATGCATA
CAATTCCCTTTCCTCAGAAGTCATTTTGGAAAACGGCAAATTGTCAGAAGGCGTAACAATAAGTTACAAATCTTACTGCAAGAACGGGGT
GAATGGAACAGGGGAAAATGGAAGAAAATGTTCCAATATTTCCATTGGAGATGAGGTTCAATTTGAAATTAGCATAACTTCAAATAAGTG
TCCAAAAAAGGATTCTGACAGCTTTAAAATTAGGCCTCTGGGCTTTACGGAGGAAGTAGAGGTTATTCTTCAGTACATCTGTGAATGTGA
ATGCCAAAGCGAAGGCATCCCTGAAAGTCCCAAGTGTCATGAAGGAAATGGGACATTTGAGTGTGGCGCGTGCAGGTGCAATGAAGGGCG
TGTTGGTAGACATTGTGAATGCAGCACAGATGAAGTTAACAGTGAAGACATGGATGCTTACTGCAGGAAAGAAAACAGTTCAGAAATCTG
CAGTAACAATGGAGAGTGCGTCTGCGGACAGTGTGTTTGTAGGAAGAGGGATAATACAAATGAAATTTATTCTGGCAAATTCTGCGAGTG
TGATAATTTCAACTGTGATAGATCCAATGGCTTAATTTGTGGAGGAAATGGTGTTTGCAAGTGTCGTGTGTGTGAGTGCAACCCCAACTA
CACTGGCAGTGCATGTGACTGTTCTTTGGATACTAGTACTTGTGAAGCCAGCAACGGACAGATCTGCAATGGCCGGGGCATCTGCGAGTG
TGGTGTCTGTAAGTGTACAGATCCGAAGTTTCAAGGGCAAACGTGTGAGATGTGTCAGACCTGCCTTGGTGTCTGTGCTGAGCATAAAGA
ATGTGTTCAGTGCAGAGCCTTCAATAAAGGAGAAAAGAAAGACACATGCACACAGGAATGTTCCTATTTTAACATTACCAAGGTAGAAAG
TCGGGACAAATTACCCCAGCCGGTCCAACCTGATCCTGTGTCCCATTGTAAGGAGAAGGATGTTGACGACTGTTGGTTCTATTTTACGTA
TTCAGTGAATGGGAACAACGAGGTCATGGTTCATGTTGTGGAGAATCCAGAGTGTCCCACTGGTCCAGACATCATTCCAATTGTAGCTGG
TGTGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTGATATGGAAGCTTTTAATGATAATTCATGACAGAAGGGAGTTTGCTAA
ATTTGAAAAGGAGAAAATGAATGCCAAATGGGACACGGAAGATGAGAATGTGCCTACTGCTCCTGATCCTCCAAGTCAACATTTACGTGG
GCATGGGACAGGCTTTTGCTTTGATTCCAGCTTTGATGTTCACAAGAAGTGTCCCCTCTGTGAGTTAATGTTTCCTCCTAACTATGATCA
GAGCAAATTTGAAGAACATGTTGAAAGTCACTGGAAGGTGTGCCCGATGTGCAGCGAGCAGTTCCCTCCTGACTATGACCAGCAGGTGTT
TGAAAGGCATGTGCAGACCCATTTTGATCAGAATGTTCTAAATTTTGACTAGTTACTTTTTATTATGAGTTAATATAGTTTAGCAGTAAA
AAAAAAAAAAAAAACCACACCTAAAATAGACCACTGAGGAGACCATAGAGCGGATGCTTTCATGCACCCTTTACTGCACTTTCTGACCAG
GAGCTACTTTGAGTTTGGTGTTACTAGGATCAGGGTCAGTCTTTGGCTTATCAATAAATTTTAATCTCTGTTAATCTTACCTGCTTTAAA

>In-frame_ENST00000396033_ENST00000543117_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(amino acids)=903AA_start in transcript=40_stop in transcript=2751
MGAVTSGLPELRGTGPERPLTPAVSRRAGQAQMNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGM
PTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGK
QRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSE
NNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNI
SIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTST
CEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPV
SHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTE
DENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVL

--------------------------------------------------------------
>In-frame_ENST00000396033_ENST00000265393_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(transcript)=2804nt_BP=2467nt
GAGCCAGCCCAGCCGCGTTCCGAACGTGAGGGTCGCCGGCCTGGGCGCTGTCACGTCGGGGCTGCCGGAGCTGCGGGGGACCGGGCCCGA
ACGGCCCCTGACACCTGCGGTCTCCCGCCGGGCTGGGCAAGCGCAGATGAATTTACAACCAATTTTCTGGATTGGACTGATCAGTTCAGT
TTGCTGTGTGTTTGCTCAAACAGATGAAAATAGATGTTTAAAAGCAAATGCCAAATCATGTGGAGAATGTATACAAGCAGGGCCAAATTG
TGGGTGGTGCACAAATTCAACATTTTTACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCCTTAAAAAAGAAGGGTTG
CCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATAAAGAAAAATAAAAATGTAACCAACCGTAGCAAAGGAACAGCAGAGAA
GCTCAAGCCAGAGGATATTACTCAGATCCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAGACATTTACATTAAAATT
CAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATGGACCTGTCTTACTCAATGAAAGACGATTTGGAGAATGTAAAAAGTCT
TGGAACAGATCTGATGAATGAAATGAGGAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAAAAGACTGTGATGCCTTA
CATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGTGAACAGAACTGCACCAGCCCATTTAGCTACAAAAATGTGCTCAGTCT
TACTAATAAAGGAGAAGTATTTAATGAACTTGTTGGAAAACAGCGCATATCTGGAAATTTGGATTCTCCAGAAGGTGGTTTCGATGCCAT
CATGCAAGTTGCAGTTTGTGGATCACTGATTGGCTGGAGGAATGTTACACGGCTGCTGGTGTTTTCCACAGATGCCGGGTTTCACTTTGC
TGGAGATGGGAAACTTGGTGGCATTGTTTTACCAAATGATGGACAATGTCACCTGGAAAATAATATGTACACAATGAGCCATTATTATGA
TTATCCTTCTATTGCTCACCTTGTCCAGAAACTGAGTGAAAATAATATTCAGACAATTTTTGCAGTTACTGAAGAATTTCAGCCTGTTTA
CAAGGAGCTGAAAAACTTGATCCCTAAGTCAGCAGTAGGAACATTATCTGCAAATTCTAGCAATGTAATTCAGTTGATCATTGATGCATA
CAATTCCCTTTCCTCAGAAGTCATTTTGGAAAACGGCAAATTGTCAGAAGGCGTAACAATAAGTTACAAATCTTACTGCAAGAACGGGGT
GAATGGAACAGGGGAAAATGGAAGAAAATGTTCCAATATTTCCATTGGAGATGAGGTTCAATTTGAAATTAGCATAACTTCAAATAAGTG
TCCAAAAAAGGATTCTGACAGCTTTAAAATTAGGCCTCTGGGCTTTACGGAGGAAGTAGAGGTTATTCTTCAGTACATCTGTGAATGTGA
ATGCCAAAGCGAAGGCATCCCTGAAAGTCCCAAGTGTCATGAAGGAAATGGGACATTTGAGTGTGGCGCGTGCAGGTGCAATGAAGGGCG
TGTTGGTAGACATTGTGAATGCAGCACAGATGAAGTTAACAGTGAAGACATGGATGCTTACTGCAGGAAAGAAAACAGTTCAGAAATCTG
CAGTAACAATGGAGAGTGCGTCTGCGGACAGTGTGTTTGTAGGAAGAGGGATAATACAAATGAAATTTATTCTGGCAAATTCTGCGAGTG
TGATAATTTCAACTGTGATAGATCCAATGGCTTAATTTGTGGAGGAAATGGTGTTTGCAAGTGTCGTGTGTGTGAGTGCAACCCCAACTA
CACTGGCAGTGCATGTGACTGTTCTTTGGATACTAGTACTTGTGAAGCCAGCAACGGACAGATCTGCAATGGCCGGGGCATCTGCGAGTG
TGGTGTCTGTAAGTGTACAGATCCGAAGTTTCAAGGGCAAACGTGTGAGATGTGTCAGACCTGCCTTGGTGTCTGTGCTGAGCATAAAGA
ATGTGTTCAGTGCAGAGCCTTCAATAAAGGAGAAAAGAAAGACACATGCACACAGGAATGTTCCTATTTTAACATTACCAAGGTAGAAAG
TCGGGACAAATTACCCCAGCCGGTCCAACCTGATCCTGTGTCCCATTGTAAGGAGAAGGATGTTGACGACTGTTGGTTCTATTTTACGTA
TTCAGTGAATGGGAACAACGAGGTCATGGTTCATGTTGTGGAGAATCCAGAGTGTCCCACTGGTCCAGACATCATTCCAATTGTAGCTGG
TGTGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTGATATGGAAGCTTTTAATGATAATTCATGACAGAAGGGAGTTTGCTAA
ATTTGAAAAGGAGAAAATGAATGCCAAATGGGACACGGAAGATGAGAATGTGCCTACTGCTCCTGATCCTCCAAGTCAACATTTACGTGG
GCATGGGACAGGCTTTTGCTTTGATTCCAGCTTTGATGTTCACAAGAAGTGTCCCCTCTGTGAGTTAATGTTTCCTCCTAACTATGATCA
GAGCAAATTTGAAGAACATGTTGAAAGTCACTGGAAGGTGTGCCCGATGTGCAGCGAGCAGTTCCCTCCTGACTATGACCAGCAGGTGTT
TGAAAGGCATGTGCAGACCCATTTTGATCAGAATGTTCTAAATTTTGACTAGTTACTTTTTATTATGAGTTAATATAGTTTAGCAGTAAA

>In-frame_ENST00000396033_ENST00000265393_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(amino acids)=903AA_start in transcript=40_stop in transcript=2751
MGAVTSGLPELRGTGPERPLTPAVSRRAGQAQMNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGM
PTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGK
QRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSE
NNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNI
SIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTST
CEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPV
SHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTE
DENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVL

--------------------------------------------------------------
>In-frame_ENST00000396033_ENST00000409980_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(transcript)=2804nt_BP=2467nt
GAGCCAGCCCAGCCGCGTTCCGAACGTGAGGGTCGCCGGCCTGGGCGCTGTCACGTCGGGGCTGCCGGAGCTGCGGGGGACCGGGCCCGA
ACGGCCCCTGACACCTGCGGTCTCCCGCCGGGCTGGGCAAGCGCAGATGAATTTACAACCAATTTTCTGGATTGGACTGATCAGTTCAGT
TTGCTGTGTGTTTGCTCAAACAGATGAAAATAGATGTTTAAAAGCAAATGCCAAATCATGTGGAGAATGTATACAAGCAGGGCCAAATTG
TGGGTGGTGCACAAATTCAACATTTTTACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCCTTAAAAAAGAAGGGTTG
CCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATAAAGAAAAATAAAAATGTAACCAACCGTAGCAAAGGAACAGCAGAGAA
GCTCAAGCCAGAGGATATTACTCAGATCCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAGACATTTACATTAAAATT
CAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATGGACCTGTCTTACTCAATGAAAGACGATTTGGAGAATGTAAAAAGTCT
TGGAACAGATCTGATGAATGAAATGAGGAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAAAAGACTGTGATGCCTTA
CATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGTGAACAGAACTGCACCAGCCCATTTAGCTACAAAAATGTGCTCAGTCT
TACTAATAAAGGAGAAGTATTTAATGAACTTGTTGGAAAACAGCGCATATCTGGAAATTTGGATTCTCCAGAAGGTGGTTTCGATGCCAT
CATGCAAGTTGCAGTTTGTGGATCACTGATTGGCTGGAGGAATGTTACACGGCTGCTGGTGTTTTCCACAGATGCCGGGTTTCACTTTGC
TGGAGATGGGAAACTTGGTGGCATTGTTTTACCAAATGATGGACAATGTCACCTGGAAAATAATATGTACACAATGAGCCATTATTATGA
TTATCCTTCTATTGCTCACCTTGTCCAGAAACTGAGTGAAAATAATATTCAGACAATTTTTGCAGTTACTGAAGAATTTCAGCCTGTTTA
CAAGGAGCTGAAAAACTTGATCCCTAAGTCAGCAGTAGGAACATTATCTGCAAATTCTAGCAATGTAATTCAGTTGATCATTGATGCATA
CAATTCCCTTTCCTCAGAAGTCATTTTGGAAAACGGCAAATTGTCAGAAGGCGTAACAATAAGTTACAAATCTTACTGCAAGAACGGGGT
GAATGGAACAGGGGAAAATGGAAGAAAATGTTCCAATATTTCCATTGGAGATGAGGTTCAATTTGAAATTAGCATAACTTCAAATAAGTG
TCCAAAAAAGGATTCTGACAGCTTTAAAATTAGGCCTCTGGGCTTTACGGAGGAAGTAGAGGTTATTCTTCAGTACATCTGTGAATGTGA
ATGCCAAAGCGAAGGCATCCCTGAAAGTCCCAAGTGTCATGAAGGAAATGGGACATTTGAGTGTGGCGCGTGCAGGTGCAATGAAGGGCG
TGTTGGTAGACATTGTGAATGCAGCACAGATGAAGTTAACAGTGAAGACATGGATGCTTACTGCAGGAAAGAAAACAGTTCAGAAATCTG
CAGTAACAATGGAGAGTGCGTCTGCGGACAGTGTGTTTGTAGGAAGAGGGATAATACAAATGAAATTTATTCTGGCAAATTCTGCGAGTG
TGATAATTTCAACTGTGATAGATCCAATGGCTTAATTTGTGGAGGAAATGGTGTTTGCAAGTGTCGTGTGTGTGAGTGCAACCCCAACTA
CACTGGCAGTGCATGTGACTGTTCTTTGGATACTAGTACTTGTGAAGCCAGCAACGGACAGATCTGCAATGGCCGGGGCATCTGCGAGTG
TGGTGTCTGTAAGTGTACAGATCCGAAGTTTCAAGGGCAAACGTGTGAGATGTGTCAGACCTGCCTTGGTGTCTGTGCTGAGCATAAAGA
ATGTGTTCAGTGCAGAGCCTTCAATAAAGGAGAAAAGAAAGACACATGCACACAGGAATGTTCCTATTTTAACATTACCAAGGTAGAAAG
TCGGGACAAATTACCCCAGCCGGTCCAACCTGATCCTGTGTCCCATTGTAAGGAGAAGGATGTTGACGACTGTTGGTTCTATTTTACGTA
TTCAGTGAATGGGAACAACGAGGTCATGGTTCATGTTGTGGAGAATCCAGAGTGTCCCACTGGTCCAGACATCATTCCAATTGTAGCTGG
TGTGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTGATATGGAAGCTTTTAATGATAATTCATGACAGAAGGGAGTTTGCTAA
ATTTGAAAAGGAGAAAATGAATGCCAAATGGGACACGGAAGATGAGAATGTGCCTACTGCTCCTGATCCTCCAAGTCAACATTTACGTGG
GCATGGGACAGGCTTTTGCTTTGATTCCAGCTTTGATGTTCACAAGAAGTGTCCCCTCTGTGAGTTAATGTTTCCTCCTAACTATGATCA
GAGCAAATTTGAAGAACATGTTGAAAGTCACTGGAAGGTGTGCCCGATGTGCAGCGAGCAGTTCCCTCCTGACTATGACCAGCAGGTGTT
TGAAAGGCATGTGCAGACCCATTTTGATCAGAATGTTCTAAATTTTGACTAGTTACTTTTTATTATGAGTTAATATAGTTTAGCAGTAAA

>In-frame_ENST00000396033_ENST00000409980_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(amino acids)=903AA_start in transcript=40_stop in transcript=2751
MGAVTSGLPELRGTGPERPLTPAVSRRAGQAQMNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGM
PTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGK
QRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSE
NNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNI
SIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTST
CEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPV
SHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTE
DENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVL

--------------------------------------------------------------
>In-frame_ENST00000396033_ENST00000433216_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(transcript)=2787nt_BP=2467nt
GAGCCAGCCCAGCCGCGTTCCGAACGTGAGGGTCGCCGGCCTGGGCGCTGTCACGTCGGGGCTGCCGGAGCTGCGGGGGACCGGGCCCGA
ACGGCCCCTGACACCTGCGGTCTCCCGCCGGGCTGGGCAAGCGCAGATGAATTTACAACCAATTTTCTGGATTGGACTGATCAGTTCAGT
TTGCTGTGTGTTTGCTCAAACAGATGAAAATAGATGTTTAAAAGCAAATGCCAAATCATGTGGAGAATGTATACAAGCAGGGCCAAATTG
TGGGTGGTGCACAAATTCAACATTTTTACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCCTTAAAAAAGAAGGGTTG
CCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATAAAGAAAAATAAAAATGTAACCAACCGTAGCAAAGGAACAGCAGAGAA
GCTCAAGCCAGAGGATATTACTCAGATCCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAGACATTTACATTAAAATT
CAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATGGACCTGTCTTACTCAATGAAAGACGATTTGGAGAATGTAAAAAGTCT
TGGAACAGATCTGATGAATGAAATGAGGAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAAAAGACTGTGATGCCTTA
CATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGTGAACAGAACTGCACCAGCCCATTTAGCTACAAAAATGTGCTCAGTCT
TACTAATAAAGGAGAAGTATTTAATGAACTTGTTGGAAAACAGCGCATATCTGGAAATTTGGATTCTCCAGAAGGTGGTTTCGATGCCAT
CATGCAAGTTGCAGTTTGTGGATCACTGATTGGCTGGAGGAATGTTACACGGCTGCTGGTGTTTTCCACAGATGCCGGGTTTCACTTTGC
TGGAGATGGGAAACTTGGTGGCATTGTTTTACCAAATGATGGACAATGTCACCTGGAAAATAATATGTACACAATGAGCCATTATTATGA
TTATCCTTCTATTGCTCACCTTGTCCAGAAACTGAGTGAAAATAATATTCAGACAATTTTTGCAGTTACTGAAGAATTTCAGCCTGTTTA
CAAGGAGCTGAAAAACTTGATCCCTAAGTCAGCAGTAGGAACATTATCTGCAAATTCTAGCAATGTAATTCAGTTGATCATTGATGCATA
CAATTCCCTTTCCTCAGAAGTCATTTTGGAAAACGGCAAATTGTCAGAAGGCGTAACAATAAGTTACAAATCTTACTGCAAGAACGGGGT
GAATGGAACAGGGGAAAATGGAAGAAAATGTTCCAATATTTCCATTGGAGATGAGGTTCAATTTGAAATTAGCATAACTTCAAATAAGTG
TCCAAAAAAGGATTCTGACAGCTTTAAAATTAGGCCTCTGGGCTTTACGGAGGAAGTAGAGGTTATTCTTCAGTACATCTGTGAATGTGA
ATGCCAAAGCGAAGGCATCCCTGAAAGTCCCAAGTGTCATGAAGGAAATGGGACATTTGAGTGTGGCGCGTGCAGGTGCAATGAAGGGCG
TGTTGGTAGACATTGTGAATGCAGCACAGATGAAGTTAACAGTGAAGACATGGATGCTTACTGCAGGAAAGAAAACAGTTCAGAAATCTG
CAGTAACAATGGAGAGTGCGTCTGCGGACAGTGTGTTTGTAGGAAGAGGGATAATACAAATGAAATTTATTCTGGCAAATTCTGCGAGTG
TGATAATTTCAACTGTGATAGATCCAATGGCTTAATTTGTGGAGGAAATGGTGTTTGCAAGTGTCGTGTGTGTGAGTGCAACCCCAACTA
CACTGGCAGTGCATGTGACTGTTCTTTGGATACTAGTACTTGTGAAGCCAGCAACGGACAGATCTGCAATGGCCGGGGCATCTGCGAGTG
TGGTGTCTGTAAGTGTACAGATCCGAAGTTTCAAGGGCAAACGTGTGAGATGTGTCAGACCTGCCTTGGTGTCTGTGCTGAGCATAAAGA
ATGTGTTCAGTGCAGAGCCTTCAATAAAGGAGAAAAGAAAGACACATGCACACAGGAATGTTCCTATTTTAACATTACCAAGGTAGAAAG
TCGGGACAAATTACCCCAGCCGGTCCAACCTGATCCTGTGTCCCATTGTAAGGAGAAGGATGTTGACGACTGTTGGTTCTATTTTACGTA
TTCAGTGAATGGGAACAACGAGGTCATGGTTCATGTTGTGGAGAATCCAGAGTGTCCCACTGGTCCAGACATCATTCCAATTGTAGCTGG
TGTGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTGATATGGAAGCTTTTAATGATAATTCATGACAGAAGGGAGTTTGCTAA
ATTTGAAAAGGAGAAAATGAATGCCAAATGGGACACGGAAGATGAGAATGTGCCTACTGCTCCTGATCCTCCAAGTCAACATTTACGTGG
GCATGGGACAGGCTTTTGCTTTGATTCCAGCTTTGATGTTCACAAGAAGTGTCCCCTCTGTGAGTTAATGTTTCCTCCTAACTATGATCA
GAGCAAATTTGAAGAACATGTTGAAAGTCACTGGAAGGTGTGCCCGATGTGCAGCGAGCAGTTCCCTCCTGACTATGACCAGCAGGTGTT

>In-frame_ENST00000396033_ENST00000433216_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(amino acids)=903AA_start in transcript=40_stop in transcript=2751
MGAVTSGLPELRGTGPERPLTPAVSRRAGQAQMNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGM
PTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGK
QRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSE
NNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNI
SIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTST
CEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPV
SHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTE
DENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVL

--------------------------------------------------------------
>In-frame_ENST00000396033_ENST00000396319_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(transcript)=3184nt_BP=2467nt
GAGCCAGCCCAGCCGCGTTCCGAACGTGAGGGTCGCCGGCCTGGGCGCTGTCACGTCGGGGCTGCCGGAGCTGCGGGGGACCGGGCCCGA
ACGGCCCCTGACACCTGCGGTCTCCCGCCGGGCTGGGCAAGCGCAGATGAATTTACAACCAATTTTCTGGATTGGACTGATCAGTTCAGT
TTGCTGTGTGTTTGCTCAAACAGATGAAAATAGATGTTTAAAAGCAAATGCCAAATCATGTGGAGAATGTATACAAGCAGGGCCAAATTG
TGGGTGGTGCACAAATTCAACATTTTTACAGGAAGGAATGCCTACTTCTGCACGATGTGATGATTTAGAAGCCTTAAAAAAGAAGGGTTG
CCCTCCAGATGACATAGAAAATCCCAGAGGCTCCAAAGATATAAAGAAAAATAAAAATGTAACCAACCGTAGCAAAGGAACAGCAGAGAA
GCTCAAGCCAGAGGATATTACTCAGATCCAACCACAGCAGTTGGTTTTGCGATTAAGATCAGGGGAGCCACAGACATTTACATTAAAATT
CAAGAGAGCTGAAGACTATCCCATTGACCTCTACTACCTTATGGACCTGTCTTACTCAATGAAAGACGATTTGGAGAATGTAAAAAGTCT
TGGAACAGATCTGATGAATGAAATGAGGAGGATTACTTCGGACTTCAGAATTGGATTTGGCTCATTTGTGGAAAAGACTGTGATGCCTTA
CATTAGCACAACACCAGCTAAGCTCAGGAACCCTTGCACAAGTGAACAGAACTGCACCAGCCCATTTAGCTACAAAAATGTGCTCAGTCT
TACTAATAAAGGAGAAGTATTTAATGAACTTGTTGGAAAACAGCGCATATCTGGAAATTTGGATTCTCCAGAAGGTGGTTTCGATGCCAT
CATGCAAGTTGCAGTTTGTGGATCACTGATTGGCTGGAGGAATGTTACACGGCTGCTGGTGTTTTCCACAGATGCCGGGTTTCACTTTGC
TGGAGATGGGAAACTTGGTGGCATTGTTTTACCAAATGATGGACAATGTCACCTGGAAAATAATATGTACACAATGAGCCATTATTATGA
TTATCCTTCTATTGCTCACCTTGTCCAGAAACTGAGTGAAAATAATATTCAGACAATTTTTGCAGTTACTGAAGAATTTCAGCCTGTTTA
CAAGGAGCTGAAAAACTTGATCCCTAAGTCAGCAGTAGGAACATTATCTGCAAATTCTAGCAATGTAATTCAGTTGATCATTGATGCATA
CAATTCCCTTTCCTCAGAAGTCATTTTGGAAAACGGCAAATTGTCAGAAGGCGTAACAATAAGTTACAAATCTTACTGCAAGAACGGGGT
GAATGGAACAGGGGAAAATGGAAGAAAATGTTCCAATATTTCCATTGGAGATGAGGTTCAATTTGAAATTAGCATAACTTCAAATAAGTG
TCCAAAAAAGGATTCTGACAGCTTTAAAATTAGGCCTCTGGGCTTTACGGAGGAAGTAGAGGTTATTCTTCAGTACATCTGTGAATGTGA
ATGCCAAAGCGAAGGCATCCCTGAAAGTCCCAAGTGTCATGAAGGAAATGGGACATTTGAGTGTGGCGCGTGCAGGTGCAATGAAGGGCG
TGTTGGTAGACATTGTGAATGCAGCACAGATGAAGTTAACAGTGAAGACATGGATGCTTACTGCAGGAAAGAAAACAGTTCAGAAATCTG
CAGTAACAATGGAGAGTGCGTCTGCGGACAGTGTGTTTGTAGGAAGAGGGATAATACAAATGAAATTTATTCTGGCAAATTCTGCGAGTG
TGATAATTTCAACTGTGATAGATCCAATGGCTTAATTTGTGGAGGAAATGGTGTTTGCAAGTGTCGTGTGTGTGAGTGCAACCCCAACTA
CACTGGCAGTGCATGTGACTGTTCTTTGGATACTAGTACTTGTGAAGCCAGCAACGGACAGATCTGCAATGGCCGGGGCATCTGCGAGTG
TGGTGTCTGTAAGTGTACAGATCCGAAGTTTCAAGGGCAAACGTGTGAGATGTGTCAGACCTGCCTTGGTGTCTGTGCTGAGCATAAAGA
ATGTGTTCAGTGCAGAGCCTTCAATAAAGGAGAAAAGAAAGACACATGCACACAGGAATGTTCCTATTTTAACATTACCAAGGTAGAAAG
TCGGGACAAATTACCCCAGCCGGTCCAACCTGATCCTGTGTCCCATTGTAAGGAGAAGGATGTTGACGACTGTTGGTTCTATTTTACGTA
TTCAGTGAATGGGAACAACGAGGTCATGGTTCATGTTGTGGAGAATCCAGAGTGTCCCACTGGTCCAGACATCATTCCAATTGTAGCTGG
TGTGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTGATATGGAAGCTTTTAATGATAATTCATGACAGAAGGGAGTTTGCTAA
ATTTGAAAAGGAGAAAATGAATGCCAAATGGGACACGGAAGATGAGAATGTGCCTACTGCTCCTGATCCTCCAAGTCAACATTTACGTGG
GCATGGGACAGGCTTTTGCTTTGATTCCAGCTTTGATGTTCACAAGAAGTGTCCCCTCTGTGAGTTAATGTTTCCTCCTAACTATGATCA
GAGCAAATTTGAAGAACATGTTGAAAGTCACTGGAAGGTGTGCCCGATGTGCAGCGAGCAGTTCCCTCCTGACTATGACCAGCAGGTGTT
TGAAAGGCATGTGCAGACCCATTTTGATCAGAATGTTCTAAATTTTGACTAGTTACTTTTTATTATGAGTTAATATAGTTTAGCAGTAAA
AAAAAAAAAAAAAACCACACCTAAAATAGACCACTGAGGAGACCATAGAGCGGATGCTTTCATGCACCCTTTACTGCACTTTCTGACCAG
GAGCTACTTTGAGTTTGGTGTTACTAGGATCAGGGTCAGTCTTTGGCTTATCAATAAATTTTAATCTCTGTTAATCTTACCTGCTTTAAA
AAAAAGTTCTTGTGTGTTCGTATCTTTATTTATTCCCTAGTTTGCAGAACTGTCTGAATAAAGGATACAAGGATTATTTCAATGTTACTG
CACTGAAAAACGTGTATGTATTAGTGTGCTAGATTATTTAGCAGAATATTCACAAGTTTCTGTTGACCTTGTTGATTGAGCATGACTACT

>In-frame_ENST00000396033_ENST00000396319_TCGA-BR-8679_ITGB1_chr10_33197295_-_TAX1BP1_chr7_27867356_length(amino acids)=903AA_start in transcript=40_stop in transcript=2751
MGAVTSGLPELRGTGPERPLTPAVSRRAGQAQMNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGM
PTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYL
MDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGK
QRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSE
NNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNI
SIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTST
CEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPV
SHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTE
DENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVL

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Fusion Gene PPI Analysis for ITGB1-TAX1BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneITGB1chr10:33197295chr7:27867356ENST00000302278-1516785_792777.0799.0ITGB1BP1
HgeneITGB1chr10:33197295chr7:27867356ENST00000374956-1517785_792777.0826.0ITGB1BP1
HgeneITGB1chr10:33197295chr7:27867356ENST00000396033-1516785_792777.0799.0ITGB1BP1
HgeneITGB1chr10:33197295chr7:27867356ENST00000423113-1416785_792777.01217.0ITGB1BP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGB1-TAX1BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneITGB1P05556DB00098Antithymocyte immunoglobulin (rabbit)BiotechApproved
HgeneITGB1P05556DB00098Antithymocyte immunoglobulin (rabbit)BiotechApproved
HgeneITGB1P05556DB00098Antithymocyte immunoglobulin (rabbit)BiotechApproved
HgeneITGB1P05556DB00098Antithymocyte immunoglobulin (rabbit)BiotechApproved

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Related Diseases for ITGB1-TAX1BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB1C0006663Calcinosis1CTD_human
HgeneITGB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneITGB1C0007137Squamous cell carcinoma1CTD_human
HgeneITGB1C0007193Cardiomyopathy, Dilated1CTD_human
HgeneITGB1C0014175Endometriosis1CTD_human
HgeneITGB1C0017639Gliosis1CTD_human
HgeneITGB1C0018801Heart failure1CTD_human
HgeneITGB1C0018802Congestive heart failure1CTD_human
HgeneITGB1C0023212Left-Sided Heart Failure1CTD_human
HgeneITGB1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneITGB1C0027626Neoplasm Invasiveness1CTD_human
HgeneITGB1C0027627Neoplasm Metastasis1CTD_human
HgeneITGB1C0033141Cardiomyopathies, Primary1CTD_human
HgeneITGB1C0036529Myocardial Diseases, Secondary1CTD_human
HgeneITGB1C0235527Heart Failure, Right-Sided1CTD_human
HgeneITGB1C0263628Tumoral calcinosis1CTD_human
HgeneITGB1C0269102Endometrioma1CTD_human
HgeneITGB1C0521174Microcalcification1CTD_human
HgeneITGB1C0878544Cardiomyopathies1CTD_human
HgeneITGB1C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneITGB1C1959583Myocardial Failure1CTD_human
HgeneITGB1C1961112Heart Decompensation1CTD_human
HgeneITGB1C3887640Astrocytosis1CTD_human