FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ITGB3BP-TTC39A (FusionGDB2 ID:40353)

Fusion Gene Summary for ITGB3BP-TTC39A

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB3BP-TTC39A
Fusion gene ID: 40353
HgeneTgene
Gene symbol

ITGB3BP

TTC39A

Gene ID

23421

22996

Gene nameintegrin subunit beta 3 binding proteintetratricopeptide repeat domain 39A
SynonymsCENP-R|CENPR|HSU37139|NRIF3|TAP20C1orf34|DEME-6
Cytomap

1p31.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptioncentromere protein Rbeta 3 endonexinbeta3-endonexinintegrin beta 3 binding protein (beta3-endonexin)integrin beta-3-binding proteinnuclear receptor-interacting factor 3tetratricopeptide repeat protein 39ATPR repeat protein 39Adifferentially expressed in MCF7 with estradiol protein 6testicular tissue protein Li 213
Modification date2020031320200313
UniProtAcc

Q13352

.
Ensembl transtripts involved in fusion geneENST00000371092, ENST00000271002, 
ENST00000283568, ENST00000461681, 
ENST00000447632, ENST00000413473, 
ENST00000262675, ENST00000451380, 
ENST00000371750, ENST00000371747, 
ENST00000262676, ENST00000530004, 
ENST00000534098, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 6 X 4=144
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB3BP [Title/Abstract] AND TTC39A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB3BP(63944435)-TTC39A(51760183), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ITGB3BP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TTC39A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A9OL-01AITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
ChimerDB4PRADTCGA-V1-A9OLITGB3BPchr1

63944435

-TTC39Achr1

51760183

-


Top

Fusion Gene ORF analysis for ITGB3BP-TTC39A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371092ENST00000447632ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000371092ENST00000413473ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000371092ENST00000262675ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000371092ENST00000451380ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000371092ENST00000371750ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000371092ENST00000371747ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000371092ENST00000262676ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000371092ENST00000530004ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-5UTRENST00000371092ENST00000534098ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000271002ENST00000447632ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000271002ENST00000413473ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000271002ENST00000262675ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000271002ENST00000451380ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
Frame-shiftENST00000271002ENST00000371750ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000271002ENST00000371747ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000271002ENST00000262676ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000271002ENST00000530004ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-5UTRENST00000271002ENST00000534098ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
In-frameENST00000283568ENST00000447632ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
In-frameENST00000283568ENST00000413473ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
In-frameENST00000283568ENST00000262675ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
In-frameENST00000283568ENST00000451380ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
In-frameENST00000283568ENST00000371750ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000283568ENST00000371747ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000283568ENST00000262676ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-intronENST00000283568ENST00000530004ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
5CDS-5UTRENST00000283568ENST00000534098ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-3CDSENST00000461681ENST00000447632ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-3CDSENST00000461681ENST00000413473ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-3CDSENST00000461681ENST00000262675ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-3CDSENST00000461681ENST00000451380ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-3CDSENST00000461681ENST00000371750ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-intronENST00000461681ENST00000371747ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-intronENST00000461681ENST00000262676ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-intronENST00000461681ENST00000530004ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-
intron-5UTRENST00000461681ENST00000534098ITGB3BPchr1

63944435

-TTC39Achr1

51760183

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283568ITGB3BPchr163944435-ENST00000447632TTC39Achr151760183-178930147889280
ENST00000283568ITGB3BPchr163944435-ENST00000413473TTC39Achr151760183-178930147889280
ENST00000283568ITGB3BPchr163944435-ENST00000262675TTC39Achr151760183-123530147889280
ENST00000283568ITGB3BPchr163944435-ENST00000451380TTC39Achr151760183-123530147889280
ENST00000283568ITGB3BPchr163944435-ENST00000371750TTC39Achr151760183-107730147889280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283568ENST00000447632ITGB3BPchr163944435-TTC39Achr151760183-0.0015064940.99849355
ENST00000283568ENST00000413473ITGB3BPchr163944435-TTC39Achr151760183-0.0015064940.99849355
ENST00000283568ENST00000262675ITGB3BPchr163944435-TTC39Achr151760183-0.0019688790.9980311
ENST00000283568ENST00000451380ITGB3BPchr163944435-TTC39Achr151760183-0.0019688790.9980311
ENST00000283568ENST00000371750ITGB3BPchr163944435-TTC39Achr151760183-0.0028856660.9971143

Top

Fusion Genomic Features for ITGB3BP-TTC39A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ITGB3BP-TTC39A


check button Go to

FGviewer for the breakpoints of chr1:63944435-chr1:51760183

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGB3BP

Q13352

.
FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269|PubMed:11713274, ECO:0000269|PubMed:12244126, ECO:0000269|PubMed:15082778, ECO:0000269|PubMed:15254226, ECO:0000269|PubMed:16622420}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000371092-51083_113123.66666666666667283.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000271002-499_1384.66666666666667262.0MotifNote=LXXLL motif
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000283568-489_1384.66666666666667171.0MotifNote=LXXLL motif
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000371092-5109_13123.66666666666667283.3333333333333MotifNote=LXXLL motif
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000271002-4920_5084.66666666666667262.0RegionNote=DD1
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000283568-4820_5084.66666666666667171.0RegionNote=DD1
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000371092-51020_50123.66666666666667283.3333333333333RegionNote=DD1
TgeneTTC39Achr1:63944435chr1:51760183ENST00000262676011315_3480421.0RepeatNote=TPR 1
TgeneTTC39Achr1:63944435chr1:51760183ENST00000262676011505_5380421.0RepeatNote=TPR 2
TgeneTTC39Achr1:63944435chr1:51760183ENST00000262676011546_5790421.0RepeatNote=TPR 3
TgeneTTC39Achr1:63944435chr1:51760183ENST000004134731218505_538385.6666666666667582.0RepeatNote=TPR 2
TgeneTTC39Achr1:63944435chr1:51760183ENST000004134731218546_579385.6666666666667582.0RepeatNote=TPR 3
TgeneTTC39Achr1:63944435chr1:51760183ENST000004476321218505_538417.6666666666667614.0RepeatNote=TPR 2
TgeneTTC39Achr1:63944435chr1:51760183ENST000004476321218546_579417.6666666666667614.0RepeatNote=TPR 3
TgeneTTC39Achr1:63944435chr1:51760183ENST000004513801218505_538381.6666666666667578.0RepeatNote=TPR 2
TgeneTTC39Achr1:63944435chr1:51760183ENST000004513801218546_579381.6666666666667578.0RepeatNote=TPR 3
TgeneTTC39Achr1:63944435chr1:51760183ENST0000053000417315_34825.666666666666668222.0RepeatNote=TPR 1
TgeneTTC39Achr1:63944435chr1:51760183ENST0000053000417505_53825.666666666666668222.0RepeatNote=TPR 2
TgeneTTC39Achr1:63944435chr1:51760183ENST0000053000417546_57925.666666666666668222.0RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000271002-4983_11384.66666666666667262.0Coiled coilOntology_term=ECO:0000255
HgeneITGB3BPchr1:63944435chr1:51760183ENST00000283568-4883_11384.66666666666667171.0Coiled coilOntology_term=ECO:0000255
TgeneTTC39Achr1:63944435chr1:51760183ENST000004134731218315_348385.6666666666667582.0RepeatNote=TPR 1
TgeneTTC39Achr1:63944435chr1:51760183ENST000004476321218315_348417.6666666666667614.0RepeatNote=TPR 1
TgeneTTC39Achr1:63944435chr1:51760183ENST000004513801218315_348381.6666666666667578.0RepeatNote=TPR 1


Top

Fusion Gene Sequence for ITGB3BP-TTC39A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000283568_ENST00000447632_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(transcript)=1789nt_BP=301nt
CTGGGTTCGTTTTATTCAGCGGCAGTGGTGCTTTCCCGAATCTCAGAATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAG
AAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAAATGAGTCTATTTG
CTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAA
GCAAAGAATCTACAACAAAAGACAATGATGAAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTG
CCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACG
CCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACG
AGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATT
TTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGG
AGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTC
GAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAG
CAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGG
GTCCACCGGCACTCCAGTTGGATGGCACAACATAGTGTATCCGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTG
CCAAGGGCAGAGCAGGTGGAGCCCTCTGCCTGCCCTATCACACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAAC
AGTTTACATTTTCCTTAGAAATACATTGATGGGATCACAGTTGGCTTTAAAAACCAACAACAATCAACCACCTGTAAGTCTTTGTCTTCA
CCTATTATCATCTGGAGGTAAATCTCTTTATATGATGATGCCAAAGGGCAAATTGCTTTTCAAATTCAGCAAGTTCTCAGCTTGTGTGAC
GGAAGGTCCTTCAGAGGACCTGAGGAATGCCTGGGAGAGGCTAAGCCTCAGGCTTCAATGCTTCTGGGGTTGGGCATGAGGATGTACACA
GACACCCACTACCTTACTACTCACACTTCATTTCACTCCTTTTGTAAATTTCCAATTTAAAAATCAAGCACGTCTTTTTAGTGAGATAAA
ATCTGAGCTCTTCTGTAGAAAAATCAATCTCTACCAGTAGAAAATGCCAGGGCTTGATGGAAGAGCTGTGTAGCCCTTTCTATGCCAAAG
CCAGGAAATTTGGGGGGCAGGAGGAGGTTCTCAGAATCCAGTCTGTATCTTTGCTGTATGCCAAACTGAAACCACTGGGAATAATTTATG

>In-frame_ENST00000283568_ENST00000447632_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(amino acids)=280AA_start in transcript=47_stop in transcript=889
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEAVPGL
KLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGL
CLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENS

--------------------------------------------------------------
>In-frame_ENST00000283568_ENST00000413473_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(transcript)=1789nt_BP=301nt
CTGGGTTCGTTTTATTCAGCGGCAGTGGTGCTTTCCCGAATCTCAGAATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAG
AAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAAATGAGTCTATTTG
CTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAA
GCAAAGAATCTACAACAAAAGACAATGATGAAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTG
CCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACG
CCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACG
AGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATT
TTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGG
AGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTC
GAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAG
CAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGG
GTCCACCGGCACTCCAGTTGGATGGCACAACATAGTGTATCCGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTG
CCAAGGGCAGAGCAGGTGGAGCCCTCTGCCTGCCCTATCACACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAAC
AGTTTACATTTTCCTTAGAAATACATTGATGGGATCACAGTTGGCTTTAAAAACCAACAACAATCAACCACCTGTAAGTCTTTGTCTTCA
CCTATTATCATCTGGAGGTAAATCTCTTTATATGATGATGCCAAAGGGCAAATTGCTTTTCAAATTCAGCAAGTTCTCAGCTTGTGTGAC
GGAAGGTCCTTCAGAGGACCTGAGGAATGCCTGGGAGAGGCTAAGCCTCAGGCTTCAATGCTTCTGGGGTTGGGCATGAGGATGTACACA
GACACCCACTACCTTACTACTCACACTTCATTTCACTCCTTTTGTAAATTTCCAATTTAAAAATCAAGCACGTCTTTTTAGTGAGATAAA
ATCTGAGCTCTTCTGTAGAAAAATCAATCTCTACCAGTAGAAAATGCCAGGGCTTGATGGAAGAGCTGTGTAGCCCTTTCTATGCCAAAG
CCAGGAAATTTGGGGGGCAGGAGGAGGTTCTCAGAATCCAGTCTGTATCTTTGCTGTATGCCAAACTGAAACCACTGGGAATAATTTATG

>In-frame_ENST00000283568_ENST00000413473_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(amino acids)=280AA_start in transcript=47_stop in transcript=889
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEAVPGL
KLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGL
CLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENS

--------------------------------------------------------------
>In-frame_ENST00000283568_ENST00000262675_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(transcript)=1235nt_BP=301nt
CTGGGTTCGTTTTATTCAGCGGCAGTGGTGCTTTCCCGAATCTCAGAATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAG
AAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAAATGAGTCTATTTG
CTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAA
GCAAAGAATCTACAACAAAAGACAATGATGAAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTG
CCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACG
CCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACG
AGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATT
TTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGG
AGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTC
GAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAG
CAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGG
GTCCACCGGCACTCCAGTTGGATGGCACAACATAGTGTATCCGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTG
CCAAGGGCAGAGCAGGTGGAGCCCTCTGCCTGCCCTATCACACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAAC

>In-frame_ENST00000283568_ENST00000262675_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(amino acids)=280AA_start in transcript=47_stop in transcript=889
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEAVPGL
KLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGL
CLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENS

--------------------------------------------------------------
>In-frame_ENST00000283568_ENST00000451380_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(transcript)=1235nt_BP=301nt
CTGGGTTCGTTTTATTCAGCGGCAGTGGTGCTTTCCCGAATCTCAGAATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAG
AAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAAATGAGTCTATTTG
CTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAA
GCAAAGAATCTACAACAAAAGACAATGATGAAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTG
CCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACG
CCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACG
AGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATT
TTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGG
AGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTC
GAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAG
CAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGG
GTCCACCGGCACTCCAGTTGGATGGCACAACATAGTGTATCCGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTG
CCAAGGGCAGAGCAGGTGGAGCCCTCTGCCTGCCCTATCACACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAAC

>In-frame_ENST00000283568_ENST00000451380_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(amino acids)=280AA_start in transcript=47_stop in transcript=889
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEAVPGL
KLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGL
CLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENS

--------------------------------------------------------------
>In-frame_ENST00000283568_ENST00000371750_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(transcript)=1077nt_BP=301nt
CTGGGTTCGTTTTATTCAGCGGCAGTGGTGCTTTCCCGAATCTCAGAATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAG
AAAATTCATTTGATCCTTCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAAATGAGTCTATTTG
CTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCAAATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAA
GCAAAGAATCTACAACAAAAGACAATGATGAAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTG
CCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACG
CCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACG
AGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATT
TTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGG
AGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTC
GAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAG
CAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGG

>In-frame_ENST00000283568_ENST00000371750_TCGA-V1-A9OL-01A_ITGB3BP_chr1_63944435_-_TTC39A_chr1_51760183_length(amino acids)=280AA_start in transcript=47_stop in transcript=889
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEAVPGL
KLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGL
CLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMESRTHFRIQAATLQAKSSLENS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ITGB3BP-TTC39A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ITGB3BP-TTC39A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ITGB3BP-TTC39A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB3BPC0014175Endometriosis1CTD_human
HgeneITGB3BPC0269102Endometrioma1CTD_human
TgeneTTC39AC0023903Liver neoplasms1CTD_human
TgeneTTC39AC0345904Malignant neoplasm of liver1CTD_human