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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGB4-PTN (FusionGDB2 ID:40369)

Fusion Gene Summary for ITGB4-PTN

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB4-PTN
Fusion gene ID: 40369
HgeneTgene
Gene symbol

ITGB4

PTN

Gene ID

3691

5764

Gene nameintegrin subunit beta 4pleiotrophin
SynonymsCD104|GP150HARP|HB-GAM|HBBM|HBGF-8|HBGF8|HBNF|HBNF-1|NEGF1|OSF-1
Cytomap

17q25.1

7q33

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-4CD104 antigenpleiotrophinheparin affin regulatory proteinheparin-binding brain mitogenheparin-binding growth factor 8heparin-binding growth-associated moleculeheparin-binding neurite outgrowth promoting factorheparin-binding neurite outgrowth-promoting factor 1
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000579662, ENST00000339591, 
ENST00000200181, ENST00000450894, 
ENST00000449880, ENST00000584558, 
ENST00000348225, ENST00000393083, 
Fusion gene scores* DoF score23 X 19 X 10=43708 X 3 X 7=168
# samples 298
** MAII scorelog2(29/4370*10)=-3.91350847437303
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB4 [Title/Abstract] AND PTN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB4(73753898)-PTN(136938384), # samples:1
Anticipated loss of major functional domain due to fusion event.ITGB4-PTN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ITGB4-PTN seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGB4

GO:0009611

response to wounding

19403692

HgeneITGB4

GO:0031581

hemidesmosome assembly

12482924

TgenePTN

GO:0007229

integrin-mediated signaling pathway

19141530

TgenePTN

GO:0008284

positive regulation of cell proliferation

1733956

TgenePTN

GO:0043113

receptor clustering

27445335

TgenePTN

GO:0043932

ossification involved in bone remodeling

19442624

TgenePTN

GO:0048714

positive regulation of oligodendrocyte differentiation

27445335


check buttonFusion gene breakpoints across ITGB4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A50M-01AITGB4chr17

73753898

-PTNchr7

136938384

-


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Fusion Gene ORF analysis for ITGB4-PTN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000579662ENST00000348225ITGB4chr17

73753898

-PTNchr7

136938384

-
intron-3CDSENST00000579662ENST00000393083ITGB4chr17

73753898

-PTNchr7

136938384

-
In-frameENST00000339591ENST00000348225ITGB4chr17

73753898

-PTNchr7

136938384

-
In-frameENST00000339591ENST00000393083ITGB4chr17

73753898

-PTNchr7

136938384

-
Frame-shiftENST00000200181ENST00000348225ITGB4chr17

73753898

-PTNchr7

136938384

-
Frame-shiftENST00000200181ENST00000393083ITGB4chr17

73753898

-PTNchr7

136938384

-
Frame-shiftENST00000450894ENST00000348225ITGB4chr17

73753898

-PTNchr7

136938384

-
Frame-shiftENST00000450894ENST00000393083ITGB4chr17

73753898

-PTNchr7

136938384

-
Frame-shiftENST00000449880ENST00000348225ITGB4chr17

73753898

-PTNchr7

136938384

-
Frame-shiftENST00000449880ENST00000393083ITGB4chr17

73753898

-PTNchr7

136938384

-
intron-3CDSENST00000584558ENST00000348225ITGB4chr17

73753898

-PTNchr7

136938384

-
intron-3CDSENST00000584558ENST00000393083ITGB4chr17

73753898

-PTNchr7

136938384

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339591ITGB4chr1773753898-ENST00000348225PTNchr7136938384-6938586716356041813
ENST00000339591ITGB4chr1773753898-ENST00000393083PTNchr7136938384-7014586716356041813

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339591ENST00000348225ITGB4chr1773753898-PTNchr7136938384-0.0016852520.99831474
ENST00000339591ENST00000393083ITGB4chr1773753898-PTNchr7136938384-0.0016428880.9983571

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Fusion Genomic Features for ITGB4-PTN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITGB4-PTN


check button Go to

FGviewer for the breakpoints of chr17:73753898-chr7:136938384

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-40401129_12181910.66666666666671823.0DomainFibronectin type-III 1
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-40401222_13211910.66666666666671823.0DomainFibronectin type-III 2
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040131_3291910.66666666666671823.0DomainNote=VWFA
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-40401530_16251910.66666666666671823.0DomainFibronectin type-III 3
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-40401643_17391910.66666666666671823.0DomainFibronectin type-III 4
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-404029_731910.66666666666671823.0DomainNote=PSI
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040979_10841910.66666666666671823.0DomainNote=Calx-beta
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-40401129_12181893.33333333333331806.0DomainFibronectin type-III 1
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-40401222_13211893.33333333333331806.0DomainFibronectin type-III 2
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040131_3291893.33333333333331806.0DomainNote=VWFA
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-40401530_16251893.33333333333331806.0DomainFibronectin type-III 3
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-40401643_17391893.33333333333331806.0DomainFibronectin type-III 4
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-404029_731893.33333333333331806.0DomainNote=PSI
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040979_10841893.33333333333331806.0DomainNote=Calx-beta
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-39391129_12181893.66666666666671806.0DomainFibronectin type-III 1
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-39391222_13211893.66666666666671806.0DomainFibronectin type-III 2
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939131_3291893.66666666666671806.0DomainNote=VWFA
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-39391530_16251893.66666666666671806.0DomainFibronectin type-III 3
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-39391643_17391893.66666666666671806.0DomainFibronectin type-III 4
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-393929_731893.66666666666671806.0DomainNote=PSI
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939979_10841893.66666666666671806.0DomainNote=Calx-beta
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-39391129_12181839.66666666666671753.0DomainFibronectin type-III 1
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-39391222_13211839.66666666666671753.0DomainFibronectin type-III 2
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939131_3291839.66666666666671753.0DomainNote=VWFA
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-39391530_16251839.66666666666671753.0DomainFibronectin type-III 3
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-39391643_17391839.66666666666671753.0DomainFibronectin type-III 4
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-393929_731839.66666666666671753.0DomainNote=PSI
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939979_10841839.66666666666671753.0DomainNote=Calx-beta
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040194_1991910.66666666666671823.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040456_6191910.66666666666671823.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040732_7491910.66666666666671823.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040194_1991893.33333333333331806.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040456_6191893.33333333333331806.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040732_7491893.33333333333331806.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939194_1991893.66666666666671806.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939456_6191893.66666666666671806.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939732_7491893.66666666666671806.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939194_1991839.66666666666671753.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939456_6191839.66666666666671753.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939732_7491839.66666666666671753.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040456_5021910.66666666666671823.0RepeatNote=I
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040503_5421910.66666666666671823.0RepeatNote=II
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040543_5811910.66666666666671823.0RepeatNote=III
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040582_6191910.66666666666671823.0RepeatNote=IV
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040456_5021893.33333333333331806.0RepeatNote=I
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040503_5421893.33333333333331806.0RepeatNote=II
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040543_5811893.33333333333331806.0RepeatNote=III
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040582_6191893.33333333333331806.0RepeatNote=IV
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939456_5021893.66666666666671806.0RepeatNote=I
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939503_5421893.66666666666671806.0RepeatNote=II
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939543_5811893.66666666666671806.0RepeatNote=III
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939582_6191893.66666666666671806.0RepeatNote=IV
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939456_5021839.66666666666671753.0RepeatNote=I
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939503_5421839.66666666666671753.0RepeatNote=II
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939543_5811839.66666666666671753.0RepeatNote=III
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939582_6191839.66666666666671753.0RepeatNote=IV
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-404028_7101910.66666666666671823.0Topological domainExtracellular
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040734_18221910.66666666666671823.0Topological domainCytoplasmic
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-404028_7101893.33333333333331806.0Topological domainExtracellular
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040734_18221893.33333333333331806.0Topological domainCytoplasmic
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-393928_7101893.66666666666671806.0Topological domainExtracellular
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939734_18221893.66666666666671806.0Topological domainCytoplasmic
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-393928_7101839.66666666666671753.0Topological domainExtracellular
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939734_18221839.66666666666671753.0Topological domainCytoplasmic
HgeneITGB4chr17:73753898chr7:136938384ENST00000200181-4040711_7331910.66666666666671823.0TransmembraneHelical
HgeneITGB4chr17:73753898chr7:136938384ENST00000339591-4040711_7331893.33333333333331806.0TransmembraneHelical
HgeneITGB4chr17:73753898chr7:136938384ENST00000449880-3939711_7331893.66666666666671806.0TransmembraneHelical
HgeneITGB4chr17:73753898chr7:136938384ENST00000450894-3939711_7331839.66666666666671753.0TransmembraneHelical
TgenePTNchr17:73753898chr7:136938384ENST0000034822515123_13138.333333333333336169.0RegionChondroitin sulfate binding
TgenePTNchr17:73753898chr7:136938384ENST0000034822515147_16838.333333333333336169.0RegionChondroitin sulfate A binding
TgenePTNchr17:73753898chr7:136938384ENST000003482251592_9938.333333333333336169.0RegionChondroitin sulfate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-1391129_121801753.0DomainFibronectin type-III 1
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-1391222_132101753.0DomainFibronectin type-III 2
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139131_32901753.0DomainNote=VWFA
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-1391530_162501753.0DomainFibronectin type-III 3
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-1391643_173901753.0DomainFibronectin type-III 4
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-13929_7301753.0DomainNote=PSI
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139979_108401753.0DomainNote=Calx-beta
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139194_19901753.0RegionInvolved in NRG1- and IGF1-binding
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139456_61901753.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139732_74901753.0RegionNote=Palmitoylated on several cysteines
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139456_50201753.0RepeatNote=I
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139503_54201753.0RepeatNote=II
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139543_58101753.0RepeatNote=III
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139582_61901753.0RepeatNote=IV
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-13928_71001753.0Topological domainExtracellular
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139734_182201753.0Topological domainCytoplasmic
HgeneITGB4chr17:73753898chr7:136938384ENST00000579662-139711_73301753.0TransmembraneHelical


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Fusion Gene Sequence for ITGB4-PTN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000339591_ENST00000348225_TCGA-85-A50M-01A_ITGB4_chr17_73753898_-_PTN_chr7_136938384_length(transcript)=6938nt_BP=5867nt
GCGCTGCCCGCCTCGTCCCCACCCCCCCAACCCCCGCGCCCGCCCTCGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATCTCCTAG
CGGCAGCCCAGGCGCGGAGGGAGCGAGTCCGCCCCGAGGTAGGTCCAGGACGGGCGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGAG
GAAGAGGATGGCAGGGCCACGCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTTGGCAAA
CCGCTGCAAGAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGGATAAGGACTGCGCCTACTGCACAGACGAGATGTTCAGGGA
CCGGCGCTGCAACACCCAGGCGGAGCTGCTGGCCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGA
GGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCATTT
TGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGACCTGTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCTGGACAA
CCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACTATTGGATTTGGCAAGTTTGTGGACAAAGT
CAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGAACGTCATCAG
CCTGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCTCCTGAGGGCGGCTTCGATGC
CATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAGTCAGCCTTCCA
CTATGAGGCTGATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCCA
GTACAGGACACAGGACTACCCGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTA
CTCCTATAGCTACTACGAGAAGCTTCACACCTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAGGACTCGTCCAACATCGTGGAGCT
GCTGGAGGAGGCCTTCAATCGGATCCGCTCCAACCTGGACATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAA
GATGTTCCAGAAGACGAGGACTGGGTCCTTTCACATCCGGCGGGGGGAAGTGGGTATATACCAGGTGCAGCTGCGGGCCCTTGAGCACGT
GGATGGGACGCACGTGTGCCAGCTGCCGGAGGACCAGAAGGGCAACATCCATCTGAAACCTTCCTTCTCCGACGGCCTCAAGATGGACGC
GGGCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCGCTGCAGCTTCAACGGAGACTTCGTGTGCGGACA
GTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGCAACTGCTCCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGCGGGAGGGCGA
GGACAAGCCGTGCTCCGGCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTCTGCGAGTA
TGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTG
GACAGGCCCAAGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGTG
TGGCCGCTGCCACTGCCACCAGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGA
CCTACGCTCCTGCGTGCAGTGCCAGGCGTGGGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAAGATGGT
GGACGAGCTTAAGAGAGCCGAGGAGGTGGTGGTGCGCTGCTCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACACCATGGAAGG
TGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGAAGGACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCT
CCTCCTCCTCCTGCCGCTCCTGGCCCTGCTACTGCTGCTATGCTGGAAGTACTGTGCCTGCTGCAAGGCCTGCCTGGCACTTCTCCCGTG
CTGCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGCCTCTGACCACTTGGACACGCCCAT
GCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGGTCACCAACAACATGCAGCGGCCTGGCTTTGCCACTCATGCCGC
CAGCATCAACCCCACAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAACCTGCTGAAGCCTGACACTCG
GGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAA
GTTCCGGCAGCAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCT
GCTGAAGCTTACAGAGAAGCAGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGA
CGCCCGGGGCATGGTGGAGTTCCAGGAGGGCGTGGAGCTGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAA
GCAGCTGCTGGTGGAGGCCATCGACGTGCCCGCAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAGC
CAGAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCGGGGACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGA
CGGCGGGAAGTCCCAGGTCTCCTACCGCACACAGGATGGCACCGCGCAGGGCAACCGGGACTACATCCCCGTGGAGGGTGAGCTGCTGTT
CCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACTCCCTCCTGCGGGGCCGCCAGGTCCGCCG
TTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGCCCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACCCAGATGAACT
GGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCCCCGCAGAACCCCAATGCTAAGGCCGC
TGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTCCGA
ATCCGAAGCCCACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGTGCGC
CTACGGGGCTCAGGGCGAGGGACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTT
CAATGTCGTCTCCTCCACGGTGACCCAGCTGAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGG
CCTGGTCAACGATGACAACCGACCTATTGGGCCCATGAAGAAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGCTTATTGAGAACCT
TCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGGGCCGGCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCAC
CCAGCCCAAGAGGCCCATGTCCATCCCCATCATCCCTGACATCCCTATCGTGGACGCCCAGAGCGGGGAGGACTACGACAGCTTCCTTAT
GTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGATGACACTGAGCACCTGGTGAATGGCCGGATGGA
CTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCTATGGCACCCACCTGAGCCCACACGTGCC
CCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACTCACTGACCCGCTCAGAACACTCACACTCGACCACACTGCCCAG
GGACTACTCCACCCTCACCTCCGTCTCCTCCCACGGCCTCCCTCCCATCTGGGAACACGGGAGGAGCAGGCTTCCGCTGTCCTGGGCCCT
GGGGTCCCGGAGTCGGGCTCAGATGAAAGGGTTCCCCCCTTCCAGGGGCCCACGAGACTCTATAATCCTGGCTGGGAGGCCAGCAGCGCC
CTCCTGGGGCCCAGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGGCCCACATCTCTCAG
AGTGAGCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACGGCGGTGAGCTGCATCGGCT
CAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGTGGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCA
GGAAGGCTGGGGCCGAGAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGCTCCGC
CTTCACTTTGAGCACTCCCAGTGCCCCAGGCCCGCTGGTGTTCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACG
GAGGCCCAATGGGGATATCGTCGGCTACCTGGTGACCTGTGAGATGGCCCAAGGAGGAGGGCCAGCCACCGCATTCCGGGTGGATGGAGA
CAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGAGAACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGG
GCCAGAGCGCGAGGGCATCATCACCATAGAGTCCCAGGATGGAGGACCCTTCCCGCAGCTGGGCAGCCGTGCCGGGCTCTTCCAGCACCC
GCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGCCCTTCCTAGTGGATGGGCTGACCCTGGGGGCCCAGCA
CCTGGAGGCAGGCGGCTCCCTCACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAGCGGAACCCTTAGCACCCACAT
GGACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTCCTCCCGACTCCTCTCCCGGAGCCTC
CTCAGCTACTCCATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCACAGAGCAGGGGCTAGGTGTCTCCTGGGAGGCATGAAGGGG
GCAAGGTCCGTCCTCTGTGGGCCCAAACCTATTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATAA
ATGGTTTTGCTACTGCTAAAAAAAAGTGAAGAAGTCTGACTGTGGAGAATGGCAGTGGAGTGTGTGTGTGCCCACCAGTGGAGACTGTGG
GCTGGGCACACGGGAGGGCACTCGGACTGGAGCTGAGTGCAAGCAAACCATGAAGACCCAGAGATGTAAGATCCCCTGCAACTGGAAGAA
GCAATTTGGCGCGGAGTGCAAATACCAGTTCCAGGCCTGGGGAGAATGTGACCTGAACACAGCCCTGAAGACCAGAACTGGAAGTCTGAA
GCGAGCCCTGCACAATGCCGAATGCCAGAAGACTGTCACCATCTCCAAGCCCTGTGGCAAACTGACCAAGCCCAAACCTCAAGCAGAATC
TAAGAAGAAGAAAAAGGAAGGCAAGAAACAGGAGAAGATGCTGGATTAAAAGATGTCACCTGTGGAACATAAAAAGGACATCAGCAAACA
GGATCAGTTAACTATTGCATTTATATGTACCGTAGGCTTTGTATTCAAAAATTATCTATAGCTAAGTACACAATAAGCAAAAACAAAAAG
AAAAGAAAATTTTTGTAGTAGCGTTTTTTAAATGTATACTATAGTACCAGTAGGGGCTTATAATAAAGGACTGTAATCTTATTTAGGAAG
TTGACTTATAGTACATGATAAATGATAGACAATTGAGGTAAGTTTTTTGAAATTATGTGACATTTTACATTAAATTTTTTTTACATTTTT
TGGGCAGCAATTTAAATGTTATGACTATGTAAACTACTTCTCTTGTTAGGTAATTTTTTTCACCTAGATTTTTTTCCCAATTGAGAAAAA
TATATACTAAACAAAATAGCAATAAAACATAATCACTCTATTTGAAGAAAATATCTTGTTTTCTGCCAATAGATTTTTTAAAATGTAGTC
AGCAAAATGGGGGTGGGGAAGCAGAGCATGTCCTAGTTCAATGTTGACTTTTTTTTTTTTTAAAGAAAAGCATTAAGACATAAAATTCTT
TCACTTTGGCAGAAGCATTTGTTTTCTTGATGAAATTATTTTTCCATCTGAGGAAAAAAATACTAGGAAAATAAATCAAGGTGATGCTGA

>In-frame_ENST00000339591_ENST00000348225_TCGA-85-A50M-01A_ITGB4_chr17_73753898_-_PTN_chr7_136938384_length(amino acids)=1813AA_start in transcript=163_stop in transcript=5604
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIH
PGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFW
WLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPG
FATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPR
SAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNIT
IIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLR
GRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYW
IQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITA
YEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGED
YDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSH
STTLPRDYSTLTSVSSHGLPPIWEHGRSRLPLSWALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSAL
GPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLC
PLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQAR
TTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSG

--------------------------------------------------------------
>In-frame_ENST00000339591_ENST00000393083_TCGA-85-A50M-01A_ITGB4_chr17_73753898_-_PTN_chr7_136938384_length(transcript)=7014nt_BP=5867nt
GCGCTGCCCGCCTCGTCCCCACCCCCCCAACCCCCGCGCCCGCCCTCGGACAGTCCCTGCTCGCCCGCGCGCTGCAGCCCCATCTCCTAG
CGGCAGCCCAGGCGCGGAGGGAGCGAGTCCGCCCCGAGGTAGGTCCAGGACGGGCGCACAGCAGCAGCCGAGGCTGGCCGGGAGAGGGAG
GAAGAGGATGGCAGGGCCACGCCCCAGCCCATGGGCCAGGCTGCTCCTGGCAGCCTTGATCAGCGTCAGCCTCTCTGGGACCTTGGCAAA
CCGCTGCAAGAAGGCCCCAGTGAAGAGCTGCACGGAGTGTGTCCGTGTGGATAAGGACTGCGCCTACTGCACAGACGAGATGTTCAGGGA
CCGGCGCTGCAACACCCAGGCGGAGCTGCTGGCCGCGGGCTGCCAGCGGGAGAGCATCGTGGTCATGGAGAGCAGCTTCCAAATCACAGA
GGAGACCCAGATTGACACCACCCTGCGGCGCAGCCAGATGTCCCCCCAAGGCCTGCGGGTCCGTCTGCGGCCCGGTGAGGAGCGGCATTT
TGAGCTGGAGGTGTTTGAGCCACTGGAGAGCCCCGTGGACCTGTACATCCTCATGGACTTCTCCAACTCCATGTCCGATGATCTGGACAA
CCTCAAGAAGATGGGGCAGAACCTGGCTCGGGTCCTGAGCCAGCTCACCAGCGACTACACTATTGGATTTGGCAAGTTTGTGGACAAAGT
CAGCGTCCCGCAGACGGACATGAGGCCTGAGAAGCTGAAGGAGCCCTGGCCCAACAGTGACCCCCCCTTCTCCTTCAAGAACGTCATCAG
CCTGACAGAAGATGTGGATGAGTTCCGGAATAAACTGCAGGGAGAGCGGATCTCAGGCAACCTGGATGCTCCTGAGGGCGGCTTCGATGC
CATCCTGCAGACAGCTGTGTGCACGAGGGACATTGGCTGGCGCCCGGACAGCACCCACCTGCTGGTCTTCTCCACCGAGTCAGCCTTCCA
CTATGAGGCTGATGGCGCCAACGTGCTGGCTGGCATCATGAGCCGCAACGATGAACGGTGCCACCTGGACACCACGGGCACCTACACCCA
GTACAGGACACAGGACTACCCGTCGGTGCCCACCCTGGTGCGCCTGCTCGCCAAGCACAACATCATCCCCATCTTTGCTGTCACCAACTA
CTCCTATAGCTACTACGAGAAGCTTCACACCTATTTCCCTGTCTCCTCACTGGGGGTGCTGCAGGAGGACTCGTCCAACATCGTGGAGCT
GCTGGAGGAGGCCTTCAATCGGATCCGCTCCAACCTGGACATCCGGGCCCTAGACAGCCCCCGAGGCCTTCGGACAGAGGTCACCTCCAA
GATGTTCCAGAAGACGAGGACTGGGTCCTTTCACATCCGGCGGGGGGAAGTGGGTATATACCAGGTGCAGCTGCGGGCCCTTGAGCACGT
GGATGGGACGCACGTGTGCCAGCTGCCGGAGGACCAGAAGGGCAACATCCATCTGAAACCTTCCTTCTCCGACGGCCTCAAGATGGACGC
GGGCATCATCTGTGATGTGTGCACCTGCGAGCTGCAAAAAGAGGTGCGGTCAGCTCGCTGCAGCTTCAACGGAGACTTCGTGTGCGGACA
GTGTGTGTGCAGCGAGGGCTGGAGTGGCCAGACCTGCAACTGCTCCACCGGCTCTCTGAGTGACATTCAGCCCTGCCTGCGGGAGGGCGA
GGACAAGCCGTGCTCCGGCCGTGGGGAGTGCCAGTGCGGGCACTGTGTGTGCTACGGCGAAGGCCGCTACGAGGGTCAGTTCTGCGAGTA
TGACAACTTCCAGTGTCCCCGCACTTCCGGGTTCCTCTGCAATGACCGAGGACGCTGCTCCATGGGCCAGTGTGTGTGTGAGCCTGGTTG
GACAGGCCCAAGCTGTGACTGTCCCCTCAGCAATGCCACCTGCATCGACAGCAATGGGGGCATCTGTAATGGACGTGGCCACTGTGAGTG
TGGCCGCTGCCACTGCCACCAGCAGTCGCTCTACACGGACACCATCTGCGAGATCAACTACTCGGCGATCCACCCGGGCCTCTGCGAGGA
CCTACGCTCCTGCGTGCAGTGCCAGGCGTGGGGCACCGGCGAGAAGAAGGGGCGCACGTGTGAGGAATGCAACTTCAAGGTCAAGATGGT
GGACGAGCTTAAGAGAGCCGAGGAGGTGGTGGTGCGCTGCTCCTTCCGGGACGAGGATGACGACTGCACCTACAGCTACACCATGGAAGG
TGACGGCGCCCCTGGGCCCAACAGCACTGTCCTGGTGCACAAGAAGAAGGACTGCCCTCCGGGCTCCTTCTGGTGGCTCATCCCCCTGCT
CCTCCTCCTCCTGCCGCTCCTGGCCCTGCTACTGCTGCTATGCTGGAAGTACTGTGCCTGCTGCAAGGCCTGCCTGGCACTTCTCCCGTG
CTGCAACCGAGGTCACATGGTGGGCTTTAAGGAAGACCACTACATGCTGCGGGAGAACCTGATGGCCTCTGACCACTTGGACACGCCCAT
GCTGCGCAGCGGGAACCTCAAGGGCCGTGACGTGGTCCGCTGGAAGGTCACCAACAACATGCAGCGGCCTGGCTTTGCCACTCATGCCGC
CAGCATCAACCCCACAGAGCTGGTGCCCTACGGGCTGTCCTTGCGCCTGGCCCGCCTTTGCACCGAGAACCTGCTGAAGCCTGACACTCG
GGAGTGCGCCCAGCTGCGCCAGGAGGTGGAGGAGAACCTGAACGAGGTCTACAGGCAGATCTCCGGTGTACACAAGCTCCAGCAGACCAA
GTTCCGGCAGCAGCCCAATGCCGGGAAAAAGCAAGACCACACCATTGTGGACACAGTGCTGATGGCGCCCCGCTCGGCCAAGCCGGCCCT
GCTGAAGCTTACAGAGAAGCAGGTGGAACAGAGGGCCTTCCACGACCTCAAGGTGGCCCCCGGCTACTACACCCTCACTGCAGACCAGGA
CGCCCGGGGCATGGTGGAGTTCCAGGAGGGCGTGGAGCTGGTGGACGTACGGGTGCCCCTCTTTATCCGGCCTGAGGATGACGACGAGAA
GCAGCTGCTGGTGGAGGCCATCGACGTGCCCGCAGGCACTGCCACCCTCGGCCGCCGCCTGGTAAACATCACCATCATCAAGGAGCAAGC
CAGAGACGTGGTGTCCTTTGAGCAGCCTGAGTTCTCGGTCAGCCGCGGGGACCAGGTGGCCCGCATCCCTGTCATCCGGCGTGTCCTGGA
CGGCGGGAAGTCCCAGGTCTCCTACCGCACACAGGATGGCACCGCGCAGGGCAACCGGGACTACATCCCCGTGGAGGGTGAGCTGCTGTT
CCAGCCTGGGGAGGCCTGGAAAGAGCTGCAGGTGAAGCTCCTGGAGCTGCAAGAAGTTGACTCCCTCCTGCGGGGCCGCCAGGTCCGCCG
TTTCCACGTCCAGCTCAGCAACCCTAAGTTTGGGGCCCACCTGGGCCAGCCCCACTCCACCACCATCATCATCAGGGACCCAGATGAACT
GGACCGGAGCTTCACGAGTCAGATGTTGTCATCACAGCCACCCCCTCACGGCGACCTGGGCGCCCCGCAGAACCCCAATGCTAAGGCCGC
TGGGTCCAGGAAGATCCATTTCAACTGGCTGCCCCCTTCTGGCAAGCCAATGGGGTACAGGGTAAAGTACTGGATTCAGGGTGACTCCGA
ATCCGAAGCCCACCTGCTCGACAGCAAGGTGCCCTCAGTGGAGCTCACCAACCTGTACCCGTATTGCGACTATGAGATGAAGGTGTGCGC
CTACGGGGCTCAGGGCGAGGGACCCTACAGCTCCCTGGTGTCCTGCCGCACCCACCAGGAAGTGCCCAGCGAGCCAGGGCGTCTGGCCTT
CAATGTCGTCTCCTCCACGGTGACCCAGCTGAGCTGGGCTGAGCCGGCTGAGACCAACGGTGAGATCACAGCCTACGAGGTCTGCTATGG
CCTGGTCAACGATGACAACCGACCTATTGGGCCCATGAAGAAAGTGCTGGTTGACAACCCTAAGAACCGGATGCTGCTTATTGAGAACCT
TCGGGAGTCCCAGCCCTACCGCTACACGGTGAAGGCGCGCAACGGGGCCGGCTGGGGGCCTGAGCGGGAGGCCATCATCAACCTGGCCAC
CCAGCCCAAGAGGCCCATGTCCATCCCCATCATCCCTGACATCCCTATCGTGGACGCCCAGAGCGGGGAGGACTACGACAGCTTCCTTAT
GTACAGCGATGACGTTCTACGCTCTCCATCGGGCAGCCAGAGGCCCAGCGTCTCCGATGACACTGAGCACCTGGTGAATGGCCGGATGGA
CTTTGCCTTCCCGGGCAGCACCAACTCCCTGCACAGGATGACCACGACCAGTGCTGCTGCCTATGGCACCCACCTGAGCCCACACGTGCC
CCACCGCGTGCTAAGCACATCCTCCACCCTCACACGGGACTACAACTCACTGACCCGCTCAGAACACTCACACTCGACCACACTGCCCAG
GGACTACTCCACCCTCACCTCCGTCTCCTCCCACGGCCTCCCTCCCATCTGGGAACACGGGAGGAGCAGGCTTCCGCTGTCCTGGGCCCT
GGGGTCCCGGAGTCGGGCTCAGATGAAAGGGTTCCCCCCTTCCAGGGGCCCACGAGACTCTATAATCCTGGCTGGGAGGCCAGCAGCGCC
CTCCTGGGGCCCAGACTCTCGCCTGACTGCTGGTGTGCCCGACACGCCCACCCGCCTGGTGTTCTCTGCCCTGGGGCCCACATCTCTCAG
AGTGAGCTGGCAGGAGCCGCGGTGCGAGCGGCCGCTGCAGGGCTACAGTGTGGAGTACCAGCTGCTGAACGGCGGTGAGCTGCATCGGCT
CAACATCCCCAACCCTGCCCAGACCTCGGTGGTGGTGGAAGACCTCCTGCCCAACCACTCCTACGTGTTCCGCGTGCGGGCCCAGAGCCA
GGAAGGCTGGGGCCGAGAGCGTGAGGGTGTCATCACCATTGAATCCCAGGTGCACCCGCAGAGCCCACTGTGTCCCCTGCCAGGCTCCGC
CTTCACTTTGAGCACTCCCAGTGCCCCAGGCCCGCTGGTGTTCACTGCCCTGAGCCCAGACTCGCTGCAGCTGAGCTGGGAGCGGCCACG
GAGGCCCAATGGGGATATCGTCGGCTACCTGGTGACCTGTGAGATGGCCCAAGGAGGAGGGCCAGCCACCGCATTCCGGGTGGATGGAGA
CAGCCCCGAGAGCCGGCTGACCGTGCCGGGCCTCAGCGAGAACGTGCCCTACAAGTTCAAGGTGCAGGCCAGGACCACTGAGGGCTTCGG
GCCAGAGCGCGAGGGCATCATCACCATAGAGTCCCAGGATGGAGGACCCTTCCCGCAGCTGGGCAGCCGTGCCGGGCTCTTCCAGCACCC
GCTGCAAAGCGAGTACAGCAGCATCACCACCACCCACACCAGCGCCACCGAGCCCTTCCTAGTGGATGGGCTGACCCTGGGGGCCCAGCA
CCTGGAGGCAGGCGGCTCCCTCACCCGGCATGTGACCCAGGAGTTTGTGAGCCGGACACTGACCACCAGCGGAACCCTTAGCACCCACAT
GGACCAACAGTTCTTCCAAACTTGACCGCACCCTGCCCCACCCCCGCCACGTCCCACTAGGCGTCCTCCCGACTCCTCTCCCGGAGCCTC
CTCAGCTACTCCATCCTTGCACCCCTGGGGGCCCAGCCCACCCGCATGCACAGAGCAGGGGCTAGGTGTCTCCTGGGAGGCATGAAGGGG
GCAAGGTCCGTCCTCTGTGGGCCCAAACCTATTTGTAACCAAAGAGCTGGGAGCAGCACAAGGACCCAGCCTTTGTTCTGCACTTAATAA
ATGGTTTTGCTACTGCTAAAAAAAAGTGAAGAAGTCTGACTGTGGAGAATGGCAGTGGAGTGTGTGTGTGCCCACCAGTGGAGACTGTGG
GCTGGGCACACGGGAGGGCACTCGGACTGGAGCTGAGTGCAAGCAAACCATGAAGACCCAGAGATGTAAGATCCCCTGCAACTGGAAGAA
GCAATTTGGCGCGGAGTGCAAATACCAGTTCCAGGCCTGGGGAGAATGTGACCTGAACACAGCCCTGAAGACCAGAACTGGAAGTCTGAA
GCGAGCCCTGCACAATGCCGAATGCCAGAAGACTGTCACCATCTCCAAGCCCTGTGGCAAACTGACCAAGCCCAAACCTCAAGAGAAGGG
AAAATGGAGACACAGGAGTGGGGAGAGTTTGAGAAGATGGTAGAGAGGAGTGTTTGGGTGAAGGGAGATGGATTCGTCTACTGATGCAAC
TGCAGAATCTAAGAAGAAGAAAAAGGAAGGCAAGAAACAGGAGAAGATGCTGGATTAAAAGATGTCACCTGTGGAACATAAAAAGGACAT
CAGCAAACAGGATCAGTTAACTATTGCATTTATATGTACCGTAGGCTTTGTATTCAAAAATTATCTATAGCTAAGTACACAATAAGCAAA
AACAAAAAGAAAAGAAAATTTTTGTAGTAGCGTTTTTTAAATGTATACTATAGTACCAGTAGGGGCTTATAATAAAGGACTGTAATCTTA
TTTAGGAAGTTGACTTATAGTACATGATAAATGATAGACAATTGAGGTAAGTTTTTTGAAATTATGTGACATTTTACATTAAATTTTTTT
TACATTTTTTGGGCAGCAATTTAAATGTTATGACTATGTAAACTACTTCTCTTGTTAGGTAATTTTTTTCACCTAGATTTTTTTCCCAAT
TGAGAAAAATATATACTAAACAAAATAGCAATAAAACATAATCACTCTATTTGAAGAAAATATCTTGTTTTCTGCCAATAGATTTTTTAA
AATGTAGTCAGCAAAATGGGGGTGGGGAAGCAGAGCATGTCCTAGTTCAATGTTGACTTTTTTTTTTTTTAAAGAAAAGCATTAAGACAT

>In-frame_ENST00000339591_ENST00000393083_TCGA-85-A50M-01A_ITGB4_chr17_73753898_-_PTN_chr7_136938384_length(amino acids)=1813AA_start in transcript=163_stop in transcript=5604
MAGRGRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMES
SFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFG
KFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFS
TESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDS
SNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSD
GLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYE
GQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIH
PGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFW
WLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPG
FATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPR
SAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNIT
IIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLR
GRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYW
IQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITA
YEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGED
YDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSH
STTLPRDYSTLTSVSSHGLPPIWEHGRSRLPLSWALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSAL
GPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLC
PLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQAR
TTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSG

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Fusion Gene PPI Analysis for ITGB4-PTN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGB4-PTN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGB4-PTN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB4C1856934Epidermolysis bullosa with pyloric atresia11CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneITGB4C0266159Pyloric Atresia2CTD_human
HgeneITGB4C0268374Adult junctional epidermolysis bullosa (disorder)2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneITGB4C0282160Aplasia Cutis Congenita2CTD_human;ORPHANET
HgeneITGB4C0000786Spontaneous abortion1CTD_human
HgeneITGB4C0000822Abortion, Tubal1CTD_human
HgeneITGB4C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneITGB4C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneITGB4C0013575Ectodermal Dysplasia1CTD_human
HgeneITGB4C0014527Epidermolysis Bullosa1CTD_human
HgeneITGB4C0017639Gliosis1CTD_human
HgeneITGB4C0036095Salivary Gland Neoplasms1CTD_human
HgeneITGB4C0079297Epidermolysis Bullosa Progressiva1CTD_human
HgeneITGB4C0079301Junctional Epidermolysis Bullosa1CTD_human
HgeneITGB4C0079683Herlitz Disease1CTD_human
HgeneITGB4C0162361Hidrotic Ectodermal Dysplasia1CTD_human
HgeneITGB4C0220636Malignant neoplasm of salivary gland1CTD_human
HgeneITGB4C1706004Anhydrotic Ectodermal Dysplasias1CTD_human
HgeneITGB4C3830362Early Pregnancy Loss1CTD_human
HgeneITGB4C3887640Astrocytosis1CTD_human
HgeneITGB4C4552766Miscarriage1CTD_human
TgenePTNC0007097Carcinoma1CTD_human
TgenePTNC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTNC0024667Animal Mammary Neoplasms1CTD_human
TgenePTNC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePTNC0205696Anaplastic carcinoma1CTD_human
TgenePTNC0205697Carcinoma, Spindle-Cell1CTD_human
TgenePTNC0205698Undifferentiated carcinoma1CTD_human
TgenePTNC0205699Carcinomatosis1CTD_human
TgenePTNC1257925Mammary Carcinoma, Animal1CTD_human