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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITGB5-PDLIM5 (FusionGDB2 ID:40387)

Fusion Gene Summary for ITGB5-PDLIM5

check button Fusion gene summary
Fusion gene informationFusion gene name: ITGB5-PDLIM5
Fusion gene ID: 40387
HgeneTgene
Gene symbol

ITGB5

PDLIM5

Gene ID

3693

10611

Gene nameintegrin subunit beta 5PDZ and LIM domain 5
Synonyms-ENH|ENH1|L9|LIM
Cytomap

3q21.2

4q22.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin beta-5testis secretory sperm-binding protein Li 217pPDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000296181, ENST00000461306, 
ENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 
Fusion gene scores* DoF score12 X 15 X 8=144015 X 18 X 7=1890
# samples 1621
** MAII scorelog2(16/1440*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITGB5 [Title/Abstract] AND PDLIM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITGB5(124578089)-PDLIM5(95507559), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ITGB5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PDLIM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1843-01AITGB5chr3

124578089

-PDLIM5chr4

95507559

+


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Fusion Gene ORF analysis for ITGB5-PDLIM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000296181ENST00000450793ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000538141ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000380180ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000318007ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000437932ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000317968ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000542407ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000508216ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
In-frameENST00000296181ENST00000514743ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
5CDS-3UTRENST00000296181ENST00000380176ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
5CDS-intronENST00000296181ENST00000359265ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
5CDS-intronENST00000296181ENST00000512274ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
5CDS-intronENST00000296181ENST00000504489ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000450793ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000538141ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000380180ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000318007ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000437932ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000317968ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000542407ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000508216ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3CDSENST00000461306ENST00000514743ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-3UTRENST00000461306ENST00000380176ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-intronENST00000461306ENST00000359265ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-intronENST00000461306ENST00000512274ITGB5chr3

124578089

-PDLIM5chr4

95507559

+
intron-intronENST00000461306ENST00000504489ITGB5chr3

124578089

-PDLIM5chr4

95507559

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296181ITGB5chr3124578089-ENST00000450793PDLIM5chr495507559+7896586162205
ENST00000296181ITGB5chr3124578089-ENST00000538141PDLIM5chr495507559+7896586162205
ENST00000296181ITGB5chr3124578089-ENST00000380180PDLIM5chr495507559+19236586162205
ENST00000296181ITGB5chr3124578089-ENST00000318007PDLIM5chr495507559+19236586162205
ENST00000296181ITGB5chr3124578089-ENST00000437932PDLIM5chr495507559+57256582971565422
ENST00000296181ITGB5chr3124578089-ENST00000317968PDLIM5chr495507559+57226582971565422
ENST00000296181ITGB5chr3124578089-ENST00000542407PDLIM5chr495507559+16856582971565422
ENST00000296181ITGB5chr3124578089-ENST00000508216PDLIM5chr495507559+1834658297788163
ENST00000296181ITGB5chr3124578089-ENST00000514743PDLIM5chr495507559+33966582971961554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296181ENST00000450793ITGB5chr3124578089-PDLIM5chr495507559+0.133281530.86671853
ENST00000296181ENST00000538141ITGB5chr3124578089-PDLIM5chr495507559+0.133281530.86671853
ENST00000296181ENST00000380180ITGB5chr3124578089-PDLIM5chr495507559+0.0300717910.96992815
ENST00000296181ENST00000318007ITGB5chr3124578089-PDLIM5chr495507559+0.0300717910.96992815
ENST00000296181ENST00000437932ITGB5chr3124578089-PDLIM5chr495507559+0.0001715650.99982846
ENST00000296181ENST00000317968ITGB5chr3124578089-PDLIM5chr495507559+0.000170380.99982965
ENST00000296181ENST00000542407ITGB5chr3124578089-PDLIM5chr495507559+0.0046740250.9953259
ENST00000296181ENST00000508216ITGB5chr3124578089-PDLIM5chr495507559+0.0311508070.9688492
ENST00000296181ENST00000514743ITGB5chr3124578089-PDLIM5chr495507559+0.0018555110.9981445

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Fusion Genomic Features for ITGB5-PDLIM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITGB5chr3124578088-PDLIM5chr495507558+0.0073008150.9926992
ITGB5chr3124578088-PDLIM5chr495507558+0.0073008150.9926992

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITGB5-PDLIM5


check button Go to

FGviewer for the breakpoints of chr3:124578089-chr4:95507559

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-31527_76120.33333333333333800.0DomainNote=PSI
TgenePDLIM5chr3:124578089chr4:95507559ENST00000317968513418_477294.3333333333333597.0DomainLIM zinc-binding 1
TgenePDLIM5chr3:124578089chr4:95507559ENST00000317968513477_536294.3333333333333597.0DomainLIM zinc-binding 2
TgenePDLIM5chr3:124578089chr4:95507559ENST00000317968513536_596294.3333333333333597.0DomainLIM zinc-binding 3
TgenePDLIM5chr3:124578089chr4:95507559ENST00000318007710418_477171.33333333333334215.0DomainLIM zinc-binding 1
TgenePDLIM5chr3:124578089chr4:95507559ENST00000318007710477_536171.33333333333334215.0DomainLIM zinc-binding 2
TgenePDLIM5chr3:124578089chr4:95507559ENST00000318007710536_596171.33333333333334215.0DomainLIM zinc-binding 3
TgenePDLIM5chr3:124578089chr4:95507559ENST00000359265032_850137.0DomainPDZ
TgenePDLIM5chr3:124578089chr4:95507559ENST0000035926503418_4770137.0DomainLIM zinc-binding 1
TgenePDLIM5chr3:124578089chr4:95507559ENST0000035926503477_5360137.0DomainLIM zinc-binding 2
TgenePDLIM5chr3:124578089chr4:95507559ENST0000035926503536_5960137.0DomainLIM zinc-binding 3
TgenePDLIM5chr3:124578089chr4:95507559ENST0000038018069418_477191.33333333333334235.0DomainLIM zinc-binding 1
TgenePDLIM5chr3:124578089chr4:95507559ENST0000038018069477_536191.33333333333334235.0DomainLIM zinc-binding 2
TgenePDLIM5chr3:124578089chr4:95507559ENST0000038018069536_596191.33333333333334235.0DomainLIM zinc-binding 3
TgenePDLIM5chr3:124578089chr4:95507559ENST00000437932513418_477185.33333333333334488.0DomainLIM zinc-binding 1
TgenePDLIM5chr3:124578089chr4:95507559ENST00000437932513477_536185.33333333333334488.0DomainLIM zinc-binding 2
TgenePDLIM5chr3:124578089chr4:95507559ENST00000437932513536_596185.33333333333334488.0DomainLIM zinc-binding 3
TgenePDLIM5chr3:124578089chr4:95507559ENST0000050821658418_477191.33333333333334235.0DomainLIM zinc-binding 1
TgenePDLIM5chr3:124578089chr4:95507559ENST0000050821658477_536191.33333333333334235.0DomainLIM zinc-binding 2
TgenePDLIM5chr3:124578089chr4:95507559ENST0000050821658536_596191.33333333333334235.0DomainLIM zinc-binding 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315136_378120.33333333333333800.0DomainNote=VWFA
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315465_630120.33333333333333800.0RegionNote=Cysteine-rich tandem repeats
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315465_512120.33333333333333800.0RepeatNote=I
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315513_554120.33333333333333800.0RepeatNote=II
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315555_593120.33333333333333800.0RepeatNote=III
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315594_630120.33333333333333800.0RepeatNote=IV
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-31524_719120.33333333333333800.0Topological domainExtracellular
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315743_799120.33333333333333800.0Topological domainCytoplasmic
HgeneITGB5chr3:124578089chr4:95507559ENST00000296181-315720_742120.33333333333333800.0TransmembraneHelical
TgenePDLIM5chr3:124578089chr4:95507559ENST000003179685132_85294.3333333333333597.0DomainPDZ
TgenePDLIM5chr3:124578089chr4:95507559ENST000003180077102_85171.33333333333334215.0DomainPDZ
TgenePDLIM5chr3:124578089chr4:95507559ENST00000380180692_85191.33333333333334235.0DomainPDZ
TgenePDLIM5chr3:124578089chr4:95507559ENST000004379325132_85185.33333333333334488.0DomainPDZ
TgenePDLIM5chr3:124578089chr4:95507559ENST00000508216582_85191.33333333333334235.0DomainPDZ


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Fusion Gene Sequence for ITGB5-PDLIM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000296181_ENST00000450793_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=789nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGGAAAAGATACCCCTTCACGTCTTT

>In-frame_ENST00000296181_ENST00000450793_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=205AA_start in transcript=616_stop in transcript=2
MTSQPAEPEPLLLRGRLLRTWKLLAGLSISPPQPFLTRFALRSHREVMDRGLPKSSLEHQAHFGWISRHSSHEVALPLVHMLRPASRGRS
AQSPRRQAYSGAGARGMVGRLPQRRRGRCTPRGPAAGAGAGARGPRAGGRSRMPRAQLRLTAPALARAPPPPSVPQHSRPSPGTAAALAG

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000538141_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=789nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGGAAAAGATACCCCTTCACGTCTTT

>In-frame_ENST00000296181_ENST00000538141_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=205AA_start in transcript=616_stop in transcript=2
MTSQPAEPEPLLLRGRLLRTWKLLAGLSISPPQPFLTRFALRSHREVMDRGLPKSSLEHQAHFGWISRHSSHEVALPLVHMLRPASRGRS
AQSPRRQAYSGAGARGMVGRLPQRRRGRCTPRGPAAGAGAGARGPRAGGRSRMPRAQLRLTAPALARAPPPPSVPQHSRPSPGTAAALAG

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000380180_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=1923nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGGAAAAGATACCCCTTCACGTCTTT
AGTCCCAAATACACAAAATTACGTGACTGGCACCATGAAGTTTCAGCACGTGCTCTTAACGTACAGTGATTTATGAGCCTTGCCCCCCAA
GCAGCCAGCACATACCTTTTCATTTACTTTTTTTTTTTCAACTTCATAGCAAAATCTGTATTAAATTTGCCTTATGAAAAAATAGAACTT
TTTCTATACTTTTCTAACAATTTCCTATTGTTGTGAGAAAAGGAAGATGAACATGTTTTGTGCTAGTTGGTAGCTCACAAATGTAAAACC
AAAAAAAAAAAAAAATAGAAAATTAAGGGACTAGATCTATTTGTGGATTTGTATCTGTTTTTGTTGTGATTAGGGTAGTAATCTTGGAAA
ACGAATTATTTTCATAAGTTGAATTTGGTTAGTTGGTTGGTTGAAGCAGAGGATAATGAGCAAATAAAGTCCTTGTCTAATTTGGAAAAT
ACTTTCTTTATATTATTAACATCTCCCAAGATTACTTTTTAAGTTCATTATTATGTTACATTCAAAGTTGATTGTAAATTATTCTAAATA
AGTAAATATAAGGAGGCAAGAATAAACAAAGACTTTATTAAAGAAGAGTGCGTGCATTGTAGATTTAGGTATCTTTTAAAGTAGGTACTA
TTCAGGATGGCTCTATGAAGAGGAGGAGGTCCAGATTTGGCTCCTGAAAAAGGAAAGAAGAGAATTTTACCCCTATTTGCAATGGAGAAA
TACAGTATTCTTTGGTTTGGTTGGATTTGCAAATCCTATTTCCTATCAAAGGAAATATCTCTAGTGGATATTTTTAGAATATAGACAATT
TCTAGGTATTAACTAATAAGATATGGAAAAGATAGCTTTGCTTTTTTTAATCAGAAGAACATAAAATAAATTACAATATGAATGATTGTG
AGACATCAGAGAAATATTTTACTTAGTGACGTAAACTACTGTGCACTGCTGCTATTCCTAGGAAGCTGTGTTTTGGGCAATACATGGAAG
CTAAATATATGACCAGAAATGCTTTCTGCCTTGTAATATAGTGTATTATATATTAGAGCTAAATTTAGTAATAAATGCATTTTGAAGTTT
GGAAAAGTATTGTAATAAAGTTGCCTTTAACTTAGCTTTGTACTTGTTCTGTTTCCTTGAGGCTAGACACAGTGCCATCCAGGACTTATT

>In-frame_ENST00000296181_ENST00000380180_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=205AA_start in transcript=616_stop in transcript=2
MTSQPAEPEPLLLRGRLLRTWKLLAGLSISPPQPFLTRFALRSHREVMDRGLPKSSLEHQAHFGWISRHSSHEVALPLVHMLRPASRGRS
AQSPRRQAYSGAGARGMVGRLPQRRRGRCTPRGPAAGAGAGARGPRAGGRSRMPRAQLRLTAPALARAPPPPSVPQHSRPSPGTAAALAG

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000318007_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=1923nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGGAAAAGATACCCCTTCACGTCTTT
AGTCCCAAATACACAAAATTACGTGACTGGCACCATGAAGTTTCAGCACGTGCTCTTAACGTACAGTGATTTATGAGCCTTGCCCCCCAA
GCAGCCAGCACATACCTTTTCATTTACTTTTTTTTTTTCAACTTCATAGCAAAATCTGTATTAAATTTGCCTTATGAAAAAATAGAACTT
TTTCTATACTTTTCTAACAATTTCCTATTGTTGTGAGAAAAGGAAGATGAACATGTTTTGTGCTAGTTGGTAGCTCACAAATGTAAAACC
AAAAAAAAAAAAAAATAGAAAATTAAGGGACTAGATCTATTTGTGGATTTGTATCTGTTTTTGTTGTGATTAGGGTAGTAATCTTGGAAA
ACGAATTATTTTCATAAGTTGAATTTGGTTAGTTGGTTGGTTGAAGCAGAGGATAATGAGCAAATAAAGTCCTTGTCTAATTTGGAAAAT
ACTTTCTTTATATTATTAACATCTCCCAAGATTACTTTTTAAGTTCATTATTATGTTACATTCAAAGTTGATTGTAAATTATTCTAAATA
AGTAAATATAAGGAGGCAAGAATAAACAAAGACTTTATTAAAGAAGAGTGCGTGCATTGTAGATTTAGGTATCTTTTAAAGTAGGTACTA
TTCAGGATGGCTCTATGAAGAGGAGGAGGTCCAGATTTGGCTCCTGAAAAAGGAAAGAAGAGAATTTTACCCCTATTTGCAATGGAGAAA
TACAGTATTCTTTGGTTTGGTTGGATTTGCAAATCCTATTTCCTATCAAAGGAAATATCTCTAGTGGATATTTTTAGAATATAGACAATT
TCTAGGTATTAACTAATAAGATATGGAAAAGATAGCTTTGCTTTTTTTAATCAGAAGAACATAAAATAAATTACAATATGAATGATTGTG
AGACATCAGAGAAATATTTTACTTAGTGACGTAAACTACTGTGCACTGCTGCTATTCCTAGGAAGCTGTGTTTTGGGCAATACATGGAAG
CTAAATATATGACCAGAAATGCTTTCTGCCTTGTAATATAGTGTATTATATATTAGAGCTAAATTTAGTAATAAATGCATTTTGAAGTTT
GGAAAAGTATTGTAATAAAGTTGCCTTTAACTTAGCTTTGTACTTGTTCTGTTTCCTTGAGGCTAGACACAGTGCCATCCAGGACTTATT

>In-frame_ENST00000296181_ENST00000318007_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=205AA_start in transcript=616_stop in transcript=2
MTSQPAEPEPLLLRGRLLRTWKLLAGLSISPPQPFLTRFALRSHREVMDRGLPKSSLEHQAHFGWISRHSSHEVALPLVHMLRPASRGRS
AQSPRRQAYSGAGARGMVGRLPQRRRGRCTPRGPAAGAGAGARGPRAGGRSRMPRAQLRLTAPALARAPPPPSVPQHSRPSPGTAAALAG

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000437932_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=5725nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAG
TTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCT
GCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGTACCTTCCACTGGAAGA
ATCTCAAACAGCGCTACTTACTCAGGATCAGTGGCACCAGCCAACTCAGCTTTGGGACAAACCCAGCCAAGTGACCAGGACACTTTAGTG
CAAAGAGCTGAGCACATTCCAGCAGGGAAACGAACTCCGATGTGCGCCCATTGTAACCAGGTCATCAGAGGACCATTCTTAGTGGCACTG
GGGAAATCTTGGCACCCAGAAGAATTCAACTGCGCTCACTGCAAAAATACAATGGCCTACATTGGATTTGTAGAGGAGAAAGGAGCCCTG
TATTGTGAGCTGTGCTATGAGAAATTCTTTGCCCCTGAATGTGGTCGATGCCAAAGGAAGATCCTTGGAGAAGTCATCAGTGCGTTGAAA
CAAACTTGGCATGTTTCCTGTTTTGTGTGTGTAGCCTGTGGAAAGCCCATTCGGAACAATGTTTTTCACTTGGAGGATGGTGAACCCTAC
TGTGAGACTGATTATTATGCCCTCTTTGGTACTATATGCCATGGATGTGAATTTCCCATAGAAGCTGGTGACATGTTCCTGGAAGCTCTG
GGCTACACCTGGCATGACACTTGCTTTGTATGCTCAGTGTGTTGTGAAAGTTTGGAAGGTCAGACCTTTTTCTCCAAGAAGGACAAGCCC
CTGTGTAAGAAACATGCTCATTCTGTGAATTTTTGAAAGTCAACAGTTCAGGAGAAGAGAAGGAATTTGAAGAGAAAAAGGAAAATTAAA
ATTACTAATTAATTTTTAGATTCAATATTTATATGGAGTTTTGAAAAATAATAGTGGCCCTGAAGGAATAAATTCCAGCTTTAAAAACCA
AGTCTGAGGAAATATTTGGCTTCATAAAGTAAAGAGACGGTTTGGCATTTATTATTACTTTTTCCTGTATTTTATGCCCATAAAATAAGC
TTTATAAAAACCAATTTCCTGATGGACTATTAAATTCATCTTAGAATAAATTAGTGAAGAATTTAATTTTAGAATAAATAATCCAATCTG
AAATAATTATACCTTCTTTCCTTGTTAGGTAGTTATGAGTAAATCTGCAAAAGGCAATGAAAATGCCTTAAATTTTATCAATAACAGAAT
TATTGTATTTAAAAAAAAACTAATACTTATCTTTAAAATAGTAAATAGGATTTTAAACAGAGAATTTTATCAGTAATAGGTGTCAGTTTT
TAAAAAATTGCTTGTAGGCTGAGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGACCACATGAGGTCAG
GAGTTTGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGACGCAGTGGCACGCGCCTGTAAT
CCCAGCTACTCAAGAGGCTGAGGCACGAGAATCACTTGAACCCGGGAGGGAGAGGTTGCAGTGAGCCAAGATCGTACCACTGCACTCCAG
CCTGGGTGACAGAGTGAGACTCTGTCTCCAAAAAAAAACTTTGCTTGTATATTATTTTTGCCTTACAGTGGATCATTCTAGTAGGAAAGG
ACAATAAGATTTTTTATCAAAATGTGTCATGCCAGTAAGAGATGTTATATTCTTTTCTCATTTCTTCCCCACCCAAAAATAAGCTACCAT
ATAGCTTATAAGTCTCAAATTTTTGCCTTTTACTAAAATGTGATTGTTTCTATTCATTGTGTATGCTTCATCACCTATATTAGGCAAATT
CCATTTTTTTCCCTTGTGCTAAGGTAAAGATTTAATTAAATAATTTTGGCCTCTCATAGTTTTCTCTCTCTTTAAAGAGAATAAATAGAG
GGCCAGGTGTGGTGGCTCACGCCTGTGATCCCAGCACTTTGGGAGGCCAAGACGGGCGGATCATGAGGTCAAGAGATCAAGATCATCCTG
GCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATGAGCTGGGCATGGTGGGGCGTGCCTGTAGTCCCATGTACTTGGGAGGC
TGAGGCAGGAAAATTCTTGAACCCAGGAGACGGAAGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGTGACAGAGCAAGAC
TCCGGCTCTTAAAAAAAAAAAAAAAAAAAAAAAAAGAGAGAGAGAGAATAAATAGAAAAGAATGTGGCTGGGAATTGTGAATCAGAAGAT
TATACCCCCCAATTGTTTTTCAATCCCCTTTTCTCAAATAATAAATTAGTTAAATCAGTTTCTGAGTTATGCCACTGGCTGATGAAGAGT
TGAGAGGTCTCTTTGCAGAATGATCTTTTTGTTTCGTTTTGTTTCTTCTTCTGCATTTAAAAATTAAAAGATTGGTTTGAGGATGTGATG
AAATTGAGACTTTTTGTGGTTTTCTCTCAATAATAAGTGAACCAATTTCAAATGTGATCACAAAGTTTGGAAAGCTTTTATTCACAGAGG
TTGGGTAGTGTTGGGAGGGGAGTTTAATTACTCAGATTGGCCTGTTATTTGATTTCCTCCTTTGGGAAAAGAATTATGTAGATACCACAT
GGAGACAGGGAAACAATTGTGGTAAAACTGTGGATCCTGTTGCTATTTGCCCAGTGAGAAAACAGATTCTGGTATTTGATTTGGTTTTTC
TCTTTGTTTCCAGAATGGATGAAAGTCCATGAACCTCCTAAGTTATAATTTAAATTTGTTTGGGGCAAGGTGATTTTATAGTCGAGACAG
AGCCCTAGGTCCTTCCTGCCCCATCACTCACTTACGACATCACTTCCATTGTGTGCATGTTTGTTATAGAGGAGGTTTTAGGCTACAATA
TTTGTTTAACCTCCCTAAGAACTTTCAAGGCATCTGTCCTGAAAGCTGTTAATTTATGGTCTAGCAGATTTATATTATATGCAGATAATA
ATTAACTGGGGATAAAAGAATGGCAAGGGGTGACACAAAGTAGCAAACTGAATACTTCTCCAATAGCAACCCCAAGCTACCTCCTCACCC
TGCATCTTGGAGGGAGGCAGGAAATTTCTTTTGAAATAAAGTGCTGGAGCTGAATTCTGCATTATTTATCGTTGCTGCTGAAACCACCTA
TAAAAGACTTGCTGGCTAATGTGCATTGTCATATAATGTACACTGTCACATCTTTACAGTCTTGTATGTTATAGAATACAAAATAAGTTG
ATGGTTTTGTTTGGTGTGAGCTTTTTGTTTGTTTGTTTAGTTTTGCCTTCATAGGTTATATGCCAAGATAGTATTTGATAAGTCAATGAC
ATTTGGATGTTTTCTTCAAAGAATTTTATTTGACCCAGATTTCTTATAAAGTTATCTTACATTAAGGATGTCATTTTCATCAGACCTTCT
TTCTACATATTATTCATGAAGCATAATGTTGCATTTCTCCAAATTTTATGCCTGAAAGGGTAGTGTTGCTTCCTAAGGTATCATGTTGTC
TTTGTGCTTTGTCCATCTCTTCCGTGGCGAAGCTTTATATCTGTTCCTAAAACAGTTAATCCTGTGAAATAAATATTGAACATAATCCAG
AAGAATCTCTCTGTTTCCCTTGGGGAATGCCATATTTAATTCACCAGCAGTAATCCTTTAATAACTGGCAGAGCACTTTATTCTTCTGGT
GAGCTCCCTGAATATTTATTTTTCTGATTATAAATTTTCTATATTAGTAGCATTTTTTAATTATTACTTCTTCACTATAGAGCATTTACT
TTTAGTCTCTAGATGTATATTTTGGAATGCTGTACTTGGCATAACATAGATTAAAATCATAATGCATGACTAAAAACTCCTTGGATTTAT
TTCCCATTTTAAAATTTTTAGCGGTAAGTTCAGATTTATAATCTTTCTCTAGACTTCCATGGTCTGAATGTTGCCTGCTGAAGTAGCAAC
CTAAAAAGTATCCCCTGCTTATGCTTGTCCAGTTGGCCCTCCATGTCCATAGGCTTCGCATCTGTGATTCAGCCCACTGTGGGTCAAAAA
TATTTGGGGAAAAAAATGGATGGTTGCGCCTTTGCTGAACATGTACAAACTTTTTTTTGTCATTAAACAATATAGTATAACAACTATTTA
CAAAGCATTTACATTGTATTAGCTATTATAGGTAATCTAGAGATGATTTAAAGTGTATGGTAGGATGTGCATAGGTTATATGCAAATACT
ACACCATTTTCTATAAGGGACTTGAACATCATGGACTTTAGTATCCTAGGGGGTTCTTGGAACCCATCACCCATAGGGGCACCATAGGAC
AACTATAGTACCGTGTTTATTTCCTATTAATTCAGGTTCCGTTTAGAGTCTAAAACTAAAACCTAATCATTTAGTCACAGTGTAAAAACA
AATGGAAATAACAGCTCAAATCTTCAAAATATTACTATAGCATTATGTTTAAAATAATCTACAACAAAAATGTACCATTTTCAAGCAGTA
CTACATTAGGAGCCCTTTTATAGAAAATAATTTCTTCTTTACCCCCGTTCCAGTGTGAATCTAGTATTCTGTTAACATTTGTGTGGCATT
TGGAGTTTGTCATCCCCATTGAAGGGAGAGCCTTCTCAGACATGAAGCAAGGGAAACATACTGAATAGTTTTACACAAATTTGATCTGGC
TTCCATTTGTCCCCCTCATTTCCCAAATGTTTAAATGTATTGGATTTGGATTCTCAATGTATAAGTTGCCTTATCTGTTAATGTCTATCT
TCTGTCTCTTTAATTTTGTATATCTGCTGTTTTGCTTTTGGATACATTTTCTAATTAGAAGTCACATGATAAATATAATCAGTATAGTAA

>In-frame_ENST00000296181_ENST00000437932_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=422AA_start in transcript=297_stop in transcript=1565
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLR
SLPLSSKGSGSAGWDVIQMTPQEIAVNLRPVKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGS
TGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEF
NCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000317968_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=5722nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAG
TTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCT
GCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGTACCTTCCACTGGAAGA
ATCTCAAACAGCGCTACTTACTCAGGATCAGTGGCACCAGCCAACTCAGCTTTGGGACAAACCCAGCCAAGTGACCAGGACACTTTAGTG
CAAAGAGCTGAGCACATTCCAGCAGGGAAACGAACTCCGATGTGCGCCCATTGTAACCAGGTCATCAGAGGACCATTCTTAGTGGCACTG
GGGAAATCTTGGCACCCAGAAGAATTCAACTGCGCTCACTGCAAAAATACAATGGCCTACATTGGATTTGTAGAGGAGAAAGGAGCCCTG
TATTGTGAGCTGTGCTATGAGAAATTCTTTGCCCCTGAATGTGGTCGATGCCAAAGGAAGATCCTTGGAGAAGTCATCAGTGCGTTGAAA
CAAACTTGGCATGTTTCCTGTTTTGTGTGTGTAGCCTGTGGAAAGCCCATTCGGAACAATGTTTTTCACTTGGAGGATGGTGAACCCTAC
TGTGAGACTGATTATTATGCCCTCTTTGGTACTATATGCCATGGATGTGAATTTCCCATAGAAGCTGGTGACATGTTCCTGGAAGCTCTG
GGCTACACCTGGCATGACACTTGCTTTGTATGCTCAGTGTGTTGTGAAAGTTTGGAAGGTCAGACCTTTTTCTCCAAGAAGGACAAGCCC
CTGTGTAAGAAACATGCTCATTCTGTGAATTTTTGAAAGTCAACAGTTCAGGAGAAGAGAAGGAATTTGAAGAGAAAAAGGAAAATTAAA
ATTACTAATTAATTTTTAGATTCAATATTTATATGGAGTTTTGAAAAATAATAGTGGCCCTGAAGGAATAAATTCCAGCTTTAAAAACCA
AGTCTGAGGAAATATTTGGCTTCATAAAGTAAAGAGACGGTTTGGCATTTATTATTACTTTTTCCTGTATTTTATGCCCATAAAATAAGC
TTTATAAAAACCAATTTCCTGATGGACTATTAAATTCATCTTAGAATAAATTAGTGAAGAATTTAATTTTAGAATAAATAATCCAATCTG
AAATAATTATACCTTCTTTCCTTGTTAGGTAGTTATGAGTAAATCTGCAAAAGGCAATGAAAATGCCTTAAATTTTATCAATAACAGAAT
TATTGTATTTAAAAAAAAACTAATACTTATCTTTAAAATAGTAAATAGGATTTTAAACAGAGAATTTTATCAGTAATAGGTGTCAGTTTT
TAAAAAATTGCTTGTAGGCTGAGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGACCACATGAGGTCAG
GAGTTTGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGACGCAGTGGCACGCGCCTGTAAT
CCCAGCTACTCAAGAGGCTGAGGCACGAGAATCACTTGAACCCGGGAGGGAGAGGTTGCAGTGAGCCAAGATCGTACCACTGCACTCCAG
CCTGGGTGACAGAGTGAGACTCTGTCTCCAAAAAAAAACTTTGCTTGTATATTATTTTTGCCTTACAGTGGATCATTCTAGTAGGAAAGG
ACAATAAGATTTTTTATCAAAATGTGTCATGCCAGTAAGAGATGTTATATTCTTTTCTCATTTCTTCCCCACCCAAAAATAAGCTACCAT
ATAGCTTATAAGTCTCAAATTTTTGCCTTTTACTAAAATGTGATTGTTTCTATTCATTGTGTATGCTTCATCACCTATATTAGGCAAATT
CCATTTTTTTCCCTTGTGCTAAGGTAAAGATTTAATTAAATAATTTTGGCCTCTCATAGTTTTCTCTCTCTTTAAAGAGAATAAATAGAG
GGCCAGGTGTGGTGGCTCACGCCTGTGATCCCAGCACTTTGGGAGGCCAAGACGGGCGGATCATGAGGTCAAGAGATCAAGATCATCCTG
GCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATGAGCTGGGCATGGTGGGGCGTGCCTGTAGTCCCATGTACTTGGGAGGC
TGAGGCAGGAAAATTCTTGAACCCAGGAGACGGAAGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGTGACAGAGCAAGAC
TCCGGCTCTTAAAAAAAAAAAAAAAAAAAAAAAAAGAGAGAGAGAGAATAAATAGAAAAGAATGTGGCTGGGAATTGTGAATCAGAAGAT
TATACCCCCCAATTGTTTTTCAATCCCCTTTTCTCAAATAATAAATTAGTTAAATCAGTTTCTGAGTTATGCCACTGGCTGATGAAGAGT
TGAGAGGTCTCTTTGCAGAATGATCTTTTTGTTTCGTTTTGTTTCTTCTTCTGCATTTAAAAATTAAAAGATTGGTTTGAGGATGTGATG
AAATTGAGACTTTTTGTGGTTTTCTCTCAATAATAAGTGAACCAATTTCAAATGTGATCACAAAGTTTGGAAAGCTTTTATTCACAGAGG
TTGGGTAGTGTTGGGAGGGGAGTTTAATTACTCAGATTGGCCTGTTATTTGATTTCCTCCTTTGGGAAAAGAATTATGTAGATACCACAT
GGAGACAGGGAAACAATTGTGGTAAAACTGTGGATCCTGTTGCTATTTGCCCAGTGAGAAAACAGATTCTGGTATTTGATTTGGTTTTTC
TCTTTGTTTCCAGAATGGATGAAAGTCCATGAACCTCCTAAGTTATAATTTAAATTTGTTTGGGGCAAGGTGATTTTATAGTCGAGACAG
AGCCCTAGGTCCTTCCTGCCCCATCACTCACTTACGACATCACTTCCATTGTGTGCATGTTTGTTATAGAGGAGGTTTTAGGCTACAATA
TTTGTTTAACCTCCCTAAGAACTTTCAAGGCATCTGTCCTGAAAGCTGTTAATTTATGGTCTAGCAGATTTATATTATATGCAGATAATA
ATTAACTGGGGATAAAAGAATGGCAAGGGGTGACACAAAGTAGCAAACTGAATACTTCTCCAATAGCAACCCCAAGCTACCTCCTCACCC
TGCATCTTGGAGGGAGGCAGGAAATTTCTTTTGAAATAAAGTGCTGGAGCTGAATTCTGCATTATTTATCGTTGCTGCTGAAACCACCTA
TAAAAGACTTGCTGGCTAATGTGCATTGTCATATAATGTACACTGTCACATCTTTACAGTCTTGTATGTTATAGAATACAAAATAAGTTG
ATGGTTTTGTTTGGTGTGAGCTTTTTGTTTGTTTGTTTAGTTTTGCCTTCATAGGTTATATGCCAAGATAGTATTTGATAAGTCAATGAC
ATTTGGATGTTTTCTTCAAAGAATTTTATTTGACCCAGATTTCTTATAAAGTTATCTTACATTAAGGATGTCATTTTCATCAGACCTTCT
TTCTACATATTATTCATGAAGCATAATGTTGCATTTCTCCAAATTTTATGCCTGAAAGGGTAGTGTTGCTTCCTAAGGTATCATGTTGTC
TTTGTGCTTTGTCCATCTCTTCCGTGGCGAAGCTTTATATCTGTTCCTAAAACAGTTAATCCTGTGAAATAAATATTGAACATAATCCAG
AAGAATCTCTCTGTTTCCCTTGGGGAATGCCATATTTAATTCACCAGCAGTAATCCTTTAATAACTGGCAGAGCACTTTATTCTTCTGGT
GAGCTCCCTGAATATTTATTTTTCTGATTATAAATTTTCTATATTAGTAGCATTTTTTAATTATTACTTCTTCACTATAGAGCATTTACT
TTTAGTCTCTAGATGTATATTTTGGAATGCTGTACTTGGCATAACATAGATTAAAATCATAATGCATGACTAAAAACTCCTTGGATTTAT
TTCCCATTTTAAAATTTTTAGCGGTAAGTTCAGATTTATAATCTTTCTCTAGACTTCCATGGTCTGAATGTTGCCTGCTGAAGTAGCAAC
CTAAAAAGTATCCCCTGCTTATGCTTGTCCAGTTGGCCCTCCATGTCCATAGGCTTCGCATCTGTGATTCAGCCCACTGTGGGTCAAAAA
TATTTGGGGAAAAAAATGGATGGTTGCGCCTTTGCTGAACATGTACAAACTTTTTTTTGTCATTAAACAATATAGTATAACAACTATTTA
CAAAGCATTTACATTGTATTAGCTATTATAGGTAATCTAGAGATGATTTAAAGTGTATGGTAGGATGTGCATAGGTTATATGCAAATACT
ACACCATTTTCTATAAGGGACTTGAACATCATGGACTTTAGTATCCTAGGGGGTTCTTGGAACCCATCACCCATAGGGGCACCATAGGAC
AACTATAGTACCGTGTTTATTTCCTATTAATTCAGGTTCCGTTTAGAGTCTAAAACTAAAACCTAATCATTTAGTCACAGTGTAAAAACA
AATGGAAATAACAGCTCAAATCTTCAAAATATTACTATAGCATTATGTTTAAAATAATCTACAACAAAAATGTACCATTTTCAAGCAGTA
CTACATTAGGAGCCCTTTTATAGAAAATAATTTCTTCTTTACCCCCGTTCCAGTGTGAATCTAGTATTCTGTTAACATTTGTGTGGCATT
TGGAGTTTGTCATCCCCATTGAAGGGAGAGCCTTCTCAGACATGAAGCAAGGGAAACATACTGAATAGTTTTACACAAATTTGATCTGGC
TTCCATTTGTCCCCCTCATTTCCCAAATGTTTAAATGTATTGGATTTGGATTCTCAATGTATAAGTTGCCTTATCTGTTAATGTCTATCT
TCTGTCTCTTTAATTTTGTATATCTGCTGTTTTGCTTTTGGATACATTTTCTAATTAGAAGTCACATGATAAATATAATCAGTATAGTAA

>In-frame_ENST00000296181_ENST00000317968_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=422AA_start in transcript=297_stop in transcript=1565
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLR
SLPLSSKGSGSAGWDVIQMTPQEIAVNLRPVKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGS
TGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEF
NCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000542407_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=1685nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAATAACTCTCAGGAGCCTTCTCCGCAG
TTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCAACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCT
GCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGGCAACGGCCAAACCAAGGAGTACCTTCCACTGGAAGA
ATCTCAAACAGCGCTACTTACTCAGGATCAGTGGCACCAGCCAACTCAGCTTTGGGACAAACCCAGCCAAGTGACCAGGACACTTTAGTG
CAAAGAGCTGAGCACATTCCAGCAGGGAAACGAACTCCGATGTGCGCCCATTGTAACCAGGTCATCAGAGGACCATTCTTAGTGGCACTG
GGGAAATCTTGGCACCCAGAAGAATTCAACTGCGCTCACTGCAAAAATACAATGGCCTACATTGGATTTGTAGAGGAGAAAGGAGCCCTG
TATTGTGAGCTGTGCTATGAGAAATTCTTTGCCCCTGAATGTGGTCGATGCCAAAGGAAGATCCTTGGAGAAGTCATCAGTGCGTTGAAA
CAAACTTGGCATGTTTCCTGTTTTGTGTGTGTAGCCTGTGGAAAGCCCATTCGGAACAATGTTTTTCACTTGGAGGATGGTGAACCCTAC
TGTGAGACTGATTATTATGCCCTCTTTGGTACTATATGCCATGGATGTGAATTTCCCATAGAAGCTGGTGACATGTTCCTGGAAGCTCTG
GGCTACACCTGGCATGACACTTGCTTTGTATGCTCAGTGTGTTGTGAAAGTTTGGAAGGTCAGACCTTTTTCTCCAAGAAGGACAAGCCC
CTGTGTAAGAAACATGCTCATTCTGTGAATTTTTGAAAGTCAACAGTTCAGGAGAAGAGAAGGAATTTGAAGAGAAAAAGGAAAATTAAA

>In-frame_ENST00000296181_ENST00000542407_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=422AA_start in transcript=297_stop in transcript=1565
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLR
SLPLSSKGSGSAGWDVIQMTPQEIAVNLRPVKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGS
TGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEF
NCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALF

--------------------------------------------------------------
>In-frame_ENST00000296181_ENST00000508216_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=1834nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGGAAAAGATACCCCTTCACGTCTTT
AGTCCCAAATACACAAAATTACGTGACTGGCACCATGAAGTTTCAGCACGTGCTCTTAACGTACAGTGATTTATGAGCCTTGCCCCCCAA
GCAGCCAGCACATACCTTTTCATTTACTTTTTTTTTTTCAACTTCATAGCAAAATCTGTATTAAATTTGCCTTATGAAAAAATAGAACTT
TTTCTATACTTTTCTAACAATTTCCTATTGTTGTGAGAAAAGGAAGATGAACATGTTTTGTGCTAGTTGGTAGCTCACAAATGTAAAACC
AAAAAAAAAAAAAAATAGAAAATTAAGGGACTAGATCTATTTGTGGATTTGTATCTGTTTTTGTTGTGATTAGGGTAGTAATCTTGGAAA
ACGAATTATTTTCATAAGTTGAATTTGGTTAGTTGGTTGGTTGAAGCAGAGGATAATGAGCAAATAAAGTCCTTGTCTAATTTGGAAAAT
ACTTTCTTTATATTATTAACATCTCCCAAGATTACTTTTTAAGTTCATTATTATGTTACATTCAAAGTTGATTGTAAATTATTCTAAATA
AGTAAATATAAGGAGGCAAGAATAAACAAAGACTTTATTAAAGAAGAGTGCGTGCATTGTAGATTTAGGTATCTTTTAAAGTAGGTACTA
TTCAGGATGGCTCTATGAAGAGGAGGAGGTCCAGATTTGGCTCCTGAAAAAGGAAAGAAGAGAATTTTACCCCTATTTGCAATGGAGAAA
TACAGTATTCTTTGGTTTGGTTGGATTTGCAAATCCTATTTCCTATCAAAGGAAATATCTCTAGTGGATATTTTTAGAATATAGACAATT
TCTAGGTATTAACTAATAAGATATGGAAAAGATAGCTTTGCTTTTTTTAATCAGAAGAACATAAAATAAATTACAATATGAATGATTGTG
AGACATCAGAGAAATATTTTACTTAGTGACGTAAACTACTGTGCACTGCTGCTATTCCTAGGAAGCTGTGTTTTGGGCAATACATGGAAG
CTAAATATATGACCAGAAATGCTTTCTGCCTTGTAATATAGTGTATTATATATTAGAGCTAAATTTAGTAATAAATGCATTTTGAAGTTT

>In-frame_ENST00000296181_ENST00000508216_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=163AA_start in transcript=297_stop in transcript=788
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLR

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>In-frame_ENST00000296181_ENST00000514743_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(transcript)=3396nt_BP=658nt
GCGGAGCCAGCCCCTCCCCTACCCGGAGCAGCCCGCTGGGGCCGTCCCGAGCGGCGACACACTAGGAGTCCCGGCCGGCCAGCCAGGGCA
GCCGCGGTCCCGGGACTCGGCCGTGAGTGCTGCGGGACGGATGGTGGCGGCGGGGCGCGGGCCAGCGCGGGCGCCGTGAGCCGGAGCTGC
GCGCGGGGCATGCGGCTGCGGCCCCCGGCCCTCGGCCCCCGCGCTCCGGCCCCAGCCCCGGCCGCCGGCCCCCGCGGAGTGCAGCGACCG
CGCCGCCGCTGAGGGAGGCGCCCCACCATGCCGCGGGCCCCGGCGCCGCTGTACGCCTGCCTCCTGGGGCTCTGCGCGCTCCTGCCCCGG
CTCGCAGGTCTCAACATATGCACTAGTGGAAGTGCCACCTCATGTGAAGAATGTCTGCTAATCCACCCAAAATGTGCCTGGTGCTCCAAA
GAGGACTTCGGAAGCCCACGGTCCATCACCTCTCGGTGTGATCTGAGGGCAAACCTTGTCAAAAATGGCTGTGGAGGTGAGATAGAGAGC
CCAGCCAGCAGCTTCCATGTCCTGAGGAGCCTGCCCCTCAGCAGCAAGGGTTCGGGCTCTGCAGGCTGGGACGTCATTCAGATGACACCA
CAGGAGATTGCCGTGAACCTCCGGCCCGTGAAAGAATCTGAAGCCGATAATACAAAGAAGGCAAAGTTTGACAGTGCTCTGGAAGACCTA
CCTAAGAGTGGACCTCACCCTCCTGCAACTCCTCAGGTGTTAACTATTGGTAGCCAAGTGGCCACACTTTCTAAAGTAGCAACTACTTAT
TCTAGTTTAAGCAGCTCCACAGGAAATGTGGAAGATTCTTTCGAAGGTTTTCGAAACTTTTCTACCTTCTCTTCTCCTGCTAGATATAGT
GCTGCAGTTCTGAGCAGCGCAGCTGCTACTGTGTCTGCTGTTATTGCTACAAAAACCAGGCTCTACACTCCTGAAAGATATCACTCACTC
CTGGATGCACTTTGCATCAGCCCTGTCTCCAAGCCTTTAGCTTTTTCCTATCTGCAGTCCTCAAGGAAATCAACTGGCTCTATCCATGTT
AAGAAAACAAGTAACTCTCAGGAGCCTTCTCCGCAGTTGGCTTCCTCGGTAGCTTCCACACGGAGCATGCCCGAGAGCCTGGACAGCCCA
ACCTCTGGCAGACCAGGGGTTACCAGCCTCACAGCTGCAGCTGCCTTCAAGCCTGTAGGATCCACTGGCGTCATCAAGTCACCAAGCTGG
CAACGGCCAAACCAAGGAGTACCTTCCACTGGAAGAATCTCAAACAGCGCTACTTACTCAGGATCAGTGGCACCAGCCAACTCAGCTTTG
GGACAAACCCAGCCAAGTGACCAGGACACTTTAGTGCAAAGAGCTGAGCACATTCCAGCAGGGAAACGAACTCCGATGTGCGCCCATTGT
AACCAGGTCATCAGAGGACCATTCTTAGTGGCACTGGGGAAATCTTGGCACCCAGAAGAATTCAACTGCGCTCACTGCAAAAATACAATG
GCCTACATTGGATTTGTAGAGGAGAAAGGAGCCCTGTATTGTGAGCTGTGCTATGAGAAATTCTTTGCCCCTGAATGTGGTCGATGCCAA
AGGAAGATCCTTGGAGAAGTCATCAGTGCGTTGAAACAAACTTGGCATGTTTCCTGTTTTGTGTGTGTAGCCTGTGGAAAGCCCATTCGG
AACAATGTTTTTCACTTGGAGGATGGTGAACCCTACTGTGAGACTGATTATTATGCCCTCTTTGGTACTATATGCCATGGATGTGAATTT
CCCATAGAAGCTGGTGACATGTTCCTGGAAGCTCTGGGCTACACCTGGCATGACACTTGCTTTGTATGCTCAGTGTGTTGTGAAAGTTTG
GAAGGTCAGACCTTTTTCTCCAAGAAGGACAAGCCCCTGTGTAAGAAACATGCTCATTCTGTGAATTTTTGAAAGTCAACAGTTCAGGAG
AAGAGAAGGAATTTGAAGAGAAAAAGGAAAATTAAAATTACTAATTAATTTTTAGATTCAATATTTATATGGAGTTTTGAAAAATAATAG
TGGCCCTGAAGGAATAAATTCCAGCTTTAAAAACCAAGTCTGAGGAAATATTTGGCTTCATAAAGTAAAGAGACGGTTTGGCATTTATTA
TTACTTTTTCCTGTATTTTATGCCCATAAAATAAGCTTTATAAAAACCAATTTCCTGATGGACTATTAAATTCATCTTAGAATAAATTAG
TGAAGAATTTAATTTTAGAATAAATAATCCAATCTGAAATAATTATACCTTCTTTCCTTGTTAGGTAGTTATGAGTAAATCTGCAAAAGG
CAATGAAAATGCCTTAAATTTTATCAATAACAGAATTATTGTATTTAAAAAAAAACTAATACTTATCTTTAAAATAGTAAATAGGATTTT
AAACAGAGAATTTTATCAGTAATAGGTGTCAGTTTTTAAAAAATTGCTTGTAGGCTGAGCGCGGTGGCTCACGCCTGTAATCCCAGCACT
TTGGGAGGCCAAGGTGGGTGGACCACATGAGGTCAGGAGTTTGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC
AAAAATTAGCCGGACGCAGTGGCACGCGCCTGTAATCCCAGCTACTCAAGAGGCTGAGGCACGAGAATCACTTGAACCCGGGAGGGAGAG
GTTGCAGTGAGCCAAGATCGTACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCCAAAAAAAAACTTTGCTTGTATATTA
TTTTTGCCTTACAGTGGATCATTCTAGTAGGAAAGGACAATAAGATTTTTTATCAAAATGTGTCATGCCAGTAAGAGATGTTATATTCTT
TTCTCATTTCTTCCCCACCCAAAAATAAGCTACCATATAGCTTATAAGTCTCAAATTTTTGCCTTTTACTAAAATGTGATTGTTTCTATT
CATTGTGTATGCTTCATCACCTATATTAGGCAAATTCCATTTTTTTCCCTTGTGCTAAGGTAAAGATTTAATTAAATAATTTTGGCCTCT
CATAGTTTTCTCTCTCTTTAAAGAGAATAAATAGAGGGCCAGGTGTGGTGGCTCACGCCTGTGATCCCAGCACTTTGGGAGGCCAAGACG
GGCGGATCATGAGGTCAAGAGATCAAGATCATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATGAGCTGGGCATG
GTGGGGCGTGCCTGTAGTCCCATGTACTTGGGAGGCTGAGGCAGGAAAATTCTTGAACCCAGGAGACGGAAGTTGCAGTGAGCTGAGATC

>In-frame_ENST00000296181_ENST00000514743_TCGA-24-1843-01A_ITGB5_chr3_124578089_-_PDLIM5_chr4_95507559_length(amino acids)=554AA_start in transcript=297_stop in transcript=1961
MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLR
SLPLSSKGSGSAGWDVIQMTPQEIAVNLRPVKESEADNTKKAKFDSALEDLPKSGPHPPATPQVLTIGSQVATLSKVATTYSSLSSSTGN
VEDSFEGFRNFSTFSSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKKTSNSQEP
SPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQD
TLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVIS
ALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKK

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Fusion Gene PPI Analysis for ITGB5-PDLIM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITGB5-PDLIM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITGB5-PDLIM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITGB5C0040128Thyroid Diseases1CTD_human
HgeneITGB5C0087031Juvenile-Onset Still Disease1CTD_human
HgeneITGB5C3495559Juvenile arthritis1CTD_human
HgeneITGB5C3714758Juvenile psoriatic arthritis1CTD_human
HgeneITGB5C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneITGB5C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgenePDLIM5C0005586Bipolar Disorder5PSYGENET
TgenePDLIM5C0036341Schizophrenia4PSYGENET
TgenePDLIM5C0041696Unipolar Depression4PSYGENET
TgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
TgenePDLIM5C0019193Hepatitis, Toxic1CTD_human
TgenePDLIM5C0151744Myocardial Ischemia1CTD_human
TgenePDLIM5C0860207Drug-Induced Liver Disease1CTD_human
TgenePDLIM5C1262760Hepatitis, Drug-Induced1CTD_human
TgenePDLIM5C3658290Drug-Induced Acute Liver Injury1CTD_human
TgenePDLIM5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePDLIM5C4279912Chemically-Induced Liver Toxicity1CTD_human