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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ITIH4-FGA (FusionGDB2 ID:40415) |
Fusion Gene Summary for ITIH4-FGA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ITIH4-FGA | Fusion gene ID: 40415 | Hgene | Tgene | Gene symbol | ITIH4 | FGA | Gene ID | 3700 | 2243 |
| Gene name | inter-alpha-trypsin inhibitor heavy chain 4 | fibrinogen alpha chain | |
| Synonyms | GP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120 | Fib2 | |
| Cytomap | 3p21.1 | 4q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inter-alpha-trypsin inhibitor heavy chain H4ITI heavy chain H4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)inter-alpha-inhibitor heavy chain 4inter-alpha-trypsin inhibitor family heavy chain-related proteininter-alpha | fibrinogen alpha chainfibrinogen, A alpha polypeptide | |
| Modification date | 20200320 | 20200315 | |
| UniProtAcc | Q14624 | P02671 | |
| Ensembl transtripts involved in fusion gene | ENST00000266041, ENST00000346281, ENST00000485816, ENST00000406595, ENST00000434759, ENST00000467462, | ENST00000302053, ENST00000403106, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 3=90 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ITIH4 [Title/Abstract] AND FGA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ITIH4(52864569)-FGA(155510714), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FGA | GO:0007160 | cell-matrix adhesion | 10903502 |
| Tgene | FGA | GO:0031639 | plasminogen activation | 16846481 |
| Tgene | FGA | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 |
| Tgene | FGA | GO:0034622 | cellular protein-containing complex assembly | 8910396 |
| Tgene | FGA | GO:0042730 | fibrinolysis | 16846481 |
| Tgene | FGA | GO:0043152 | induction of bacterial agglutination | 24367264 |
| Tgene | FGA | GO:0045907 | positive regulation of vasoconstriction | 15739255 |
| Tgene | FGA | GO:0045921 | positive regulation of exocytosis | 19193866 |
| Tgene | FGA | GO:0050714 | positive regulation of protein secretion | 19193866 |
| Tgene | FGA | GO:0051258 | protein polymerization | 12706644 |
| Tgene | FGA | GO:0051592 | response to calcium ion | 6777381 |
| Tgene | FGA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502|19193866 |
| Tgene | FGA | GO:0070527 | platelet aggregation | 6281794 |
| Tgene | FGA | GO:0072378 | blood coagulation, fibrin clot formation | 16846481 |
| Tgene | FGA | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 |
| Tgene | FGA | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
| Tgene | FGA | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
| Fusion gene breakpoints across ITIH4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across FGA (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-BC-A10Z-11A | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
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Fusion Gene ORF analysis for ITIH4-FGA |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000266041 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000266041 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000346281 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000346281 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000485816 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000485816 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000406595 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| In-frame | ENST00000406595 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| 5UTR-3CDS | ENST00000434759 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| 5UTR-3CDS | ENST00000434759 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| intron-3CDS | ENST00000467462 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| intron-3CDS | ENST00000467462 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000266041 | ITIH4 | chr3 | 52864569 | - | ENST00000302053 | FGA | chr4 | 155510714 | - | 3732 | 187 | 76 | 2733 | 885 |
| ENST00000266041 | ITIH4 | chr3 | 52864569 | - | ENST00000403106 | FGA | chr4 | 155510714 | - | 2302 | 187 | 76 | 2067 | 663 |
| ENST00000346281 | ITIH4 | chr3 | 52864569 | - | ENST00000302053 | FGA | chr4 | 155510714 | - | 3694 | 149 | 38 | 2695 | 885 |
| ENST00000346281 | ITIH4 | chr3 | 52864569 | - | ENST00000403106 | FGA | chr4 | 155510714 | - | 2264 | 149 | 38 | 2029 | 663 |
| ENST00000485816 | ITIH4 | chr3 | 52864569 | - | ENST00000302053 | FGA | chr4 | 155510714 | - | 3666 | 121 | 10 | 2667 | 885 |
| ENST00000485816 | ITIH4 | chr3 | 52864569 | - | ENST00000403106 | FGA | chr4 | 155510714 | - | 2236 | 121 | 10 | 2001 | 663 |
| ENST00000406595 | ITIH4 | chr3 | 52864569 | - | ENST00000302053 | FGA | chr4 | 155510714 | - | 3665 | 120 | 9 | 2666 | 885 |
| ENST00000406595 | ITIH4 | chr3 | 52864569 | - | ENST00000403106 | FGA | chr4 | 155510714 | - | 2235 | 120 | 9 | 2000 | 663 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000266041 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.000394458 | 0.9996056 |
| ENST00000266041 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.002283309 | 0.99771667 |
| ENST00000346281 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.000398895 | 0.99960107 |
| ENST00000346281 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.002387143 | 0.99761283 |
| ENST00000485816 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.000413124 | 0.9995869 |
| ENST00000485816 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.002575734 | 0.99742424 |
| ENST00000406595 | ENST00000302053 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.000409687 | 0.99959034 |
| ENST00000406595 | ENST00000403106 | ITIH4 | chr3 | 52864569 | - | FGA | chr4 | 155510714 | - | 0.002539221 | 0.9974607 |
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Fusion Genomic Features for ITIH4-FGA |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ITIH4-FGA |
| Go to FGviewer for the breakpoints of chr3:52864569-chr4:155510714 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ITIH4 | FGA |
| FUNCTION: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:19263524}. | FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FGA | chr3:52864569 | chr4:155510714 | ENST00000302053 | 0 | 6 | 68_631 | 18.0 | 867.0 | Coiled coil | Ontology_term=ECO:0000305 | |
| Tgene | FGA | chr3:52864569 | chr4:155510714 | ENST00000403106 | 0 | 5 | 68_631 | 18.0 | 645.0 | Coiled coil | Ontology_term=ECO:0000305 | |
| Tgene | FGA | chr3:52864569 | chr4:155510714 | ENST00000302053 | 0 | 6 | 623_864 | 18.0 | 867.0 | Domain | Fibrinogen C-terminal | |
| Tgene | FGA | chr3:52864569 | chr4:155510714 | ENST00000403106 | 0 | 5 | 623_864 | 18.0 | 645.0 | Domain | Fibrinogen C-terminal | |
| Tgene | FGA | chr3:52864569 | chr4:155510714 | ENST00000302053 | 0 | 6 | 36_38 | 18.0 | 867.0 | Region | Note=Alpha-chain polymerization%2C binding distal domain of another fibrin gamma chain | |
| Tgene | FGA | chr3:52864569 | chr4:155510714 | ENST00000403106 | 0 | 5 | 36_38 | 18.0 | 645.0 | Region | Note=Alpha-chain polymerization%2C binding distal domain of another fibrin gamma chain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000266041 | - | 1 | 24 | 272_432 | 30.0 | 931.0 | Domain | VWFA |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000266041 | - | 1 | 24 | 29_148 | 30.0 | 931.0 | Domain | VIT |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000346281 | - | 1 | 22 | 272_432 | 30.0 | 915.0 | Domain | VWFA |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000346281 | - | 1 | 22 | 29_148 | 30.0 | 915.0 | Domain | VIT |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000406595 | - | 1 | 22 | 272_432 | 30.0 | 901.0 | Domain | VWFA |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000406595 | - | 1 | 22 | 29_148 | 30.0 | 901.0 | Domain | VIT |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000266041 | - | 1 | 24 | 658_688 | 30.0 | 931.0 | Region | Note=Proline-rich (PRR) potential bioactive peptide |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000266041 | - | 1 | 24 | 719_725 | 30.0 | 931.0 | Region | Note=O-glycosylated at three sites |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000346281 | - | 1 | 22 | 658_688 | 30.0 | 915.0 | Region | Note=Proline-rich (PRR) potential bioactive peptide |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000346281 | - | 1 | 22 | 719_725 | 30.0 | 915.0 | Region | Note=O-glycosylated at three sites |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000406595 | - | 1 | 22 | 658_688 | 30.0 | 901.0 | Region | Note=Proline-rich (PRR) potential bioactive peptide |
| Hgene | ITIH4 | chr3:52864569 | chr4:155510714 | ENST00000406595 | - | 1 | 22 | 719_725 | 30.0 | 901.0 | Region | Note=O-glycosylated at three sites |
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Fusion Gene Sequence for ITIH4-FGA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000266041_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=3732nt_BP=187nt AACCTGCCCCCATGTGGGTGGGGCAGCAAACAAGTTACTAATCCATTCCCCACTTGCTGTCGAGTTCAGAAGCCTCCTGGCAGACACTGG AGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCTGGCCATCCACCAGACTACTACTGC CGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAGGGTTGTGGAAAGACATCAATCTGC CTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGGAACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGA AGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAACAATAAGGATTCTCATTCGTTGAC CACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGTGATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAG CAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAATGTTAGAGCTCAGTTGGTTGATAT GAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGA CTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAAT GAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCA GATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCC CAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGG AGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGAACTGGAAGTACTGGAAA CCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGA GAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTGGGAACGCGAGGCCTAA CAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTC TAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCGTTAC TAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGA TTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGG AAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAA TACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAG CACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAAC ACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGACTGTGATGATGTCCTCCAAACACATCCTTCAGGTACCCAAAGTGG CATTTTCAATATCAAGCTACCGGGATCCAGTAAGATTTTTTCTGTTTATTGCGATCAAGAGACCAGTTTGGGAGGATGGCTTTTGATCCA GCAAAGAATGGATGGATCACTGAATTTTAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAGCCTGAATGACGAGGGGGAAGGAGA ATTCTGGCTAGGCAATGACTACCTCCACTTACTAACCCAAAGGGGCTCTGTTCTTAGGGTTGAATTAGAGGACTGGGCTGGGAATGAAGC TTATGCAGAATATCACTTCCGGGTAGGCTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTATGAAGGCACTGCGGGTGATGCTCT GATTGAGGGTTCCGTAGAGGAAGGGGCAGAGTACACCTCTCACAACAACATGCAGTTCAGCACCTTTGACAGGGATGCAGACCAGTGGGA AGAGAACTGTGCAGAAGTCTATGGGGGAGGCTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAATGGAATCTACTACCCTGGGGGCTC CTATGACCCAAGGAATAACAGTCCTTATGAGATTGAGAATGGAGTGGTCTGGGTTTCCTTTAGAGGGGCAGATTATTCCCTCAGGGCTGT TCGCATGAAAATTAGGCCCCTTGTGACCCAATAGGCTGAAGAAGTGGGAATGGGAGCACTCTGTCTTCTTTGCTAGAGAAGTGGAGAGAA AATACAAAAGGTAAAGCAGTTGAGATTCTCTACAACCTAAAAAATTCCTAGGTGCTATTTTCTTATCCTTTGTACTGTAGCTAAATGTAC CTGAGACATATTAGTCTTTGAAAAATAAAGTTATGTAAGGTTTTTTTTATCTTTAAATAGCTCTGTGGGTTTTAACATTTTTATAAAGAT ATACCAAGGGCCATTCAGTACATCAGGAAAGTGGCAGACAGAAGCTTCTCTCTGCAACCTTGAAGACTATTGGTTTGAGAACTTCTCTTC CCATACCACCCAAAATCATAATGCCATTGGAAAGCAAAAAGTTGTTTTATCCATTTGATTTGAATTGTTTTAAGCCAATATTTTAAGGTA AAACTCACTGAATCTAACCATAGCTGACCTTTGTAGTAGAATTTACAACTTATAATTACAATGCACAATTTATAATTACAATATGTATTT ATGTCTTTTGCTATGGAGCAAATCCAGGAAGGCAAGAGAAACATTCTTTCCTAAATATAAATGAAAATCTATCCTTTAAACTCTTCCACT AGACGTTGTAATGCACACTTATTTTTTTCCCAAGGAGTAACCAATTTCTTTCTAAAACACATTTAAAATTTTAAAACTATTTATGAATAT TAAAAAAAGACATAATTCACACATTAATAAACAATCTCCCAAGTATTGATTTAACTTCATTTTTCTAATAATCATAAACTATATTCTGTG ACATGCTAATTATTATTAAATGTAAGTCGTTAGTTCGAAAGCCTCTCACTAAGTATGATCTATGCTATATTCAAAATTCAACCCATTTAC TTTGGTCAATATTTGATCTAAGTTGCATCTTTAATCCTGGTGGTCTTGCCTTCTGATTTTTAATTTGTATCCTTTTCTATTAAGATATAT >In-frame_ENST00000266041_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=885AA_start in transcript=76_stop in transcript=2733 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA DHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLND EGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRD -------------------------------------------------------------- >In-frame_ENST00000266041_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=2302nt_BP=187nt AACCTGCCCCCATGTGGGTGGGGCAGCAAACAAGTTACTAATCCATTCCCCACTTGCTGTCGAGTTCAGAAGCCTCCTGGCAGACACTGG AGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCTGGCCATCCACCAGACTACTACTGC CGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAGGGTTGTGGAAAGACATCAATCTGC CTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGGAACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGA AGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAACAATAAGGATTCTCATTCGTTGAC CACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGTGATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAG CAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAATGTTAGAGCTCAGTTGGTTGATAT GAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGA CTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAAT GAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCA GATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCC CAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGG AGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGAACTGGAAGTACTGGAAA CCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGA GAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTGGGAACGCGAGGCCTAA CAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTC TAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCGTTAC TAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGA TTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGG AAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAA TACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAG CACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAAC ACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGGTATCCACACTTCTCCTTTGGGGAAGCCTTCCCTGTCCCCCTAGAC TAAGTTAAATATTTCTGCACAGTGTTCCCATGGCCCCTTGCATTTCCTTCTTAACTCTCTGTTACACGTCATTGAAACTACACTTTTTTG GTCTGTTTTTGTGCTAGACTGTAAGTTCCTTGGGGGCAGGGCCTTTGTCTGTCTCATCTCTGTATTCCCAAATGCCTAACAGTACAGAGC >In-frame_ENST00000266041_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=663AA_start in transcript=76_stop in transcript=2067 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA -------------------------------------------------------------- >In-frame_ENST00000346281_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=3694nt_BP=149nt TAATCCATTCCCCACTTGCTGTCGAGTTCAGAAGCCTCCTGGCAGACACTGGAGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCA GCAAAGTTCTCGTCCTGCTTTCACTGCTGGCCATCCACCAGACTACTACTGCCGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAG CTGAAGGAGGAGGCGTGCGTGGCCCAAGGGTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAG ACTGGAACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCA AAAATTCACTATTTGAATATCAGAAGAACAATAAGGATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCT CAGCCAATAACCGTGATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAG TACAGCATATCCAGCTTCTGCAGAAAAATGTTAGAGCTCAGTTGGTTGATATGAAACGACTGGAGGTGGACATTGATATTAAGATCCGAT CTTGTCGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTG CCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGA GCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGA TTACTCGAGGAGGCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGA GCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTG GAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAA CCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTG AATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAA ATGTAAGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGG TCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTA CCAAAGAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGT TCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAG AGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTG AATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCA AGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTG TCAGAGACTGTGATGATGTCCTCCAAACACATCCTTCAGGTACCCAAAGTGGCATTTTCAATATCAAGCTACCGGGATCCAGTAAGATTT TTTCTGTTTATTGCGATCAAGAGACCAGTTTGGGAGGATGGCTTTTGATCCAGCAAAGAATGGATGGATCACTGAATTTTAACCGGACCT GGCAAGACTACAAGAGAGGTTTCGGCAGCCTGAATGACGAGGGGGAAGGAGAATTCTGGCTAGGCAATGACTACCTCCACTTACTAACCC AAAGGGGCTCTGTTCTTAGGGTTGAATTAGAGGACTGGGCTGGGAATGAAGCTTATGCAGAATATCACTTCCGGGTAGGCTCTGAGGCTG AAGGCTATGCCCTCCAAGTCTCCTCCTATGAAGGCACTGCGGGTGATGCTCTGATTGAGGGTTCCGTAGAGGAAGGGGCAGAGTACACCT CTCACAACAACATGCAGTTCAGCACCTTTGACAGGGATGCAGACCAGTGGGAAGAGAACTGTGCAGAAGTCTATGGGGGAGGCTGGTGGT ATAATAACTGCCAAGCAGCCAATCTCAATGGAATCTACTACCCTGGGGGCTCCTATGACCCAAGGAATAACAGTCCTTATGAGATTGAGA ATGGAGTGGTCTGGGTTTCCTTTAGAGGGGCAGATTATTCCCTCAGGGCTGTTCGCATGAAAATTAGGCCCCTTGTGACCCAATAGGCTG AAGAAGTGGGAATGGGAGCACTCTGTCTTCTTTGCTAGAGAAGTGGAGAGAAAATACAAAAGGTAAAGCAGTTGAGATTCTCTACAACCT AAAAAATTCCTAGGTGCTATTTTCTTATCCTTTGTACTGTAGCTAAATGTACCTGAGACATATTAGTCTTTGAAAAATAAAGTTATGTAA GGTTTTTTTTATCTTTAAATAGCTCTGTGGGTTTTAACATTTTTATAAAGATATACCAAGGGCCATTCAGTACATCAGGAAAGTGGCAGA CAGAAGCTTCTCTCTGCAACCTTGAAGACTATTGGTTTGAGAACTTCTCTTCCCATACCACCCAAAATCATAATGCCATTGGAAAGCAAA AAGTTGTTTTATCCATTTGATTTGAATTGTTTTAAGCCAATATTTTAAGGTAAAACTCACTGAATCTAACCATAGCTGACCTTTGTAGTA GAATTTACAACTTATAATTACAATGCACAATTTATAATTACAATATGTATTTATGTCTTTTGCTATGGAGCAAATCCAGGAAGGCAAGAG AAACATTCTTTCCTAAATATAAATGAAAATCTATCCTTTAAACTCTTCCACTAGACGTTGTAATGCACACTTATTTTTTTCCCAAGGAGT AACCAATTTCTTTCTAAAACACATTTAAAATTTTAAAACTATTTATGAATATTAAAAAAAGACATAATTCACACATTAATAAACAATCTC CCAAGTATTGATTTAACTTCATTTTTCTAATAATCATAAACTATATTCTGTGACATGCTAATTATTATTAAATGTAAGTCGTTAGTTCGA AAGCCTCTCACTAAGTATGATCTATGCTATATTCAAAATTCAACCCATTTACTTTGGTCAATATTTGATCTAAGTTGCATCTTTAATCCT GGTGGTCTTGCCTTCTGATTTTTAATTTGTATCCTTTTCTATTAAGATATATTTGTCATTTTCTCTTGAATATGTATTAAAATATCCCAA >In-frame_ENST00000346281_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=885AA_start in transcript=38_stop in transcript=2695 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA DHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLND EGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRD -------------------------------------------------------------- >In-frame_ENST00000346281_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=2264nt_BP=149nt TAATCCATTCCCCACTTGCTGTCGAGTTCAGAAGCCTCCTGGCAGACACTGGAGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCA GCAAAGTTCTCGTCCTGCTTTCACTGCTGGCCATCCACCAGACTACTACTGCCGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAG CTGAAGGAGGAGGCGTGCGTGGCCCAAGGGTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAG ACTGGAACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCA AAAATTCACTATTTGAATATCAGAAGAACAATAAGGATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCT CAGCCAATAACCGTGATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAG TACAGCATATCCAGCTTCTGCAGAAAAATGTTAGAGCTCAGTTGGTTGATATGAAACGACTGGAGGTGGACATTGATATTAAGATCCGAT CTTGTCGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTG CCAAAGACTTACTTCCCTCTAGAGATAGGCAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGA GCCAGCTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGA TTACTCGAGGAGGCTCCACCTCTTATGGAACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGA GCTCTGGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTG GAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAA CCTGGAATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTG AATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAA ATGTAAGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGG TCACCTCTGGTAGCACAACCACCACGCGTCGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTA CCAAAGAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGT TCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAG AGTTTGTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTG AATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCA AGAGCTATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTG TCAGAGGTATCCACACTTCTCCTTTGGGGAAGCCTTCCCTGTCCCCCTAGACTAAGTTAAATATTTCTGCACAGTGTTCCCATGGCCCCT TGCATTTCCTTCTTAACTCTCTGTTACACGTCATTGAAACTACACTTTTTTGGTCTGTTTTTGTGCTAGACTGTAAGTTCCTTGGGGGCA GGGCCTTTGTCTGTCTCATCTCTGTATTCCCAAATGCCTAACAGTACAGAGCCATGACTCAATAAATACATGTTAAATGGATGAATGAAT >In-frame_ENST00000346281_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=663AA_start in transcript=38_stop in transcript=2029 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA -------------------------------------------------------------- >In-frame_ENST00000485816_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=3666nt_BP=121nt CAGAAGCCTCCTGGCAGACACTGGAGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCT GGCCATCCACCAGACTACTACTGCCGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAG GGTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGGAACTACAAATGCCCTTCTGGCTG CAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAA CAATAAGGATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGTGATAATACCTACAA CCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAA TGTTAGAGCTCAGTTGGTTGATATGAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTT AGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAG GCAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTG GAAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGG AACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCG AAACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAG CTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGG AAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCC AGGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTA CCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCG TCGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGG TTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGC CTTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGG CTCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAG TTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGG AAGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGACTGTGATGATGTCCTCCAAAC ACATCCTTCAGGTACCCAAAGTGGCATTTTCAATATCAAGCTACCGGGATCCAGTAAGATTTTTTCTGTTTATTGCGATCAAGAGACCAG TTTGGGAGGATGGCTTTTGATCCAGCAAAGAATGGATGGATCACTGAATTTTAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAG CCTGAATGACGAGGGGGAAGGAGAATTCTGGCTAGGCAATGACTACCTCCACTTACTAACCCAAAGGGGCTCTGTTCTTAGGGTTGAATT AGAGGACTGGGCTGGGAATGAAGCTTATGCAGAATATCACTTCCGGGTAGGCTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTA TGAAGGCACTGCGGGTGATGCTCTGATTGAGGGTTCCGTAGAGGAAGGGGCAGAGTACACCTCTCACAACAACATGCAGTTCAGCACCTT TGACAGGGATGCAGACCAGTGGGAAGAGAACTGTGCAGAAGTCTATGGGGGAGGCTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAA TGGAATCTACTACCCTGGGGGCTCCTATGACCCAAGGAATAACAGTCCTTATGAGATTGAGAATGGAGTGGTCTGGGTTTCCTTTAGAGG GGCAGATTATTCCCTCAGGGCTGTTCGCATGAAAATTAGGCCCCTTGTGACCCAATAGGCTGAAGAAGTGGGAATGGGAGCACTCTGTCT TCTTTGCTAGAGAAGTGGAGAGAAAATACAAAAGGTAAAGCAGTTGAGATTCTCTACAACCTAAAAAATTCCTAGGTGCTATTTTCTTAT CCTTTGTACTGTAGCTAAATGTACCTGAGACATATTAGTCTTTGAAAAATAAAGTTATGTAAGGTTTTTTTTATCTTTAAATAGCTCTGT GGGTTTTAACATTTTTATAAAGATATACCAAGGGCCATTCAGTACATCAGGAAAGTGGCAGACAGAAGCTTCTCTCTGCAACCTTGAAGA CTATTGGTTTGAGAACTTCTCTTCCCATACCACCCAAAATCATAATGCCATTGGAAAGCAAAAAGTTGTTTTATCCATTTGATTTGAATT GTTTTAAGCCAATATTTTAAGGTAAAACTCACTGAATCTAACCATAGCTGACCTTTGTAGTAGAATTTACAACTTATAATTACAATGCAC AATTTATAATTACAATATGTATTTATGTCTTTTGCTATGGAGCAAATCCAGGAAGGCAAGAGAAACATTCTTTCCTAAATATAAATGAAA ATCTATCCTTTAAACTCTTCCACTAGACGTTGTAATGCACACTTATTTTTTTCCCAAGGAGTAACCAATTTCTTTCTAAAACACATTTAA AATTTTAAAACTATTTATGAATATTAAAAAAAGACATAATTCACACATTAATAAACAATCTCCCAAGTATTGATTTAACTTCATTTTTCT AATAATCATAAACTATATTCTGTGACATGCTAATTATTATTAAATGTAAGTCGTTAGTTCGAAAGCCTCTCACTAAGTATGATCTATGCT ATATTCAAAATTCAACCCATTTACTTTGGTCAATATTTGATCTAAGTTGCATCTTTAATCCTGGTGGTCTTGCCTTCTGATTTTTAATTT >In-frame_ENST00000485816_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=885AA_start in transcript=10_stop in transcript=2667 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA DHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLND EGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRD -------------------------------------------------------------- >In-frame_ENST00000485816_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=2236nt_BP=121nt CAGAAGCCTCCTGGCAGACACTGGAGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCT GGCCATCCACCAGACTACTACTGCCGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAG GGTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGGAACTACAAATGCCCTTCTGGCTG CAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAA CAATAAGGATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGTGATAATACCTACAA CCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAA TGTTAGAGCTCAGTTGGTTGATATGAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTT AGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAG GCAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTG GAAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGG AACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCG AAACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAG CTCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGG AAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCC AGGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTA CCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCG TCGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGG TTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGC CTTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGG CTCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAG TTACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGG AAGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGGTATCCACACTTCTCCTTTGGG GAAGCCTTCCCTGTCCCCCTAGACTAAGTTAAATATTTCTGCACAGTGTTCCCATGGCCCCTTGCATTTCCTTCTTAACTCTCTGTTACA CGTCATTGAAACTACACTTTTTTGGTCTGTTTTTGTGCTAGACTGTAAGTTCCTTGGGGGCAGGGCCTTTGTCTGTCTCATCTCTGTATT >In-frame_ENST00000485816_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=663AA_start in transcript=10_stop in transcript=2001 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA -------------------------------------------------------------- >In-frame_ENST00000406595_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=3665nt_BP=120nt AGAAGCCTCCTGGCAGACACTGGAGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCTG GCCATCCACCAGACTACTACTGCCGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAGG GTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGGAACTACAAATGCCCTTCTGGCTGC AGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAAC AATAAGGATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGTGATAATACCTACAAC CGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAAT GTTAGAGCTCAGTTGGTTGATATGAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTTA GCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGG CAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGG AAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGA ACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGA AACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGC TCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGGA AGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCA GGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTAC CACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGT CGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGGT TCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCC TTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGC TCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGT TACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGA AGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGACTGTGATGATGTCCTCCAAACA CATCCTTCAGGTACCCAAAGTGGCATTTTCAATATCAAGCTACCGGGATCCAGTAAGATTTTTTCTGTTTATTGCGATCAAGAGACCAGT TTGGGAGGATGGCTTTTGATCCAGCAAAGAATGGATGGATCACTGAATTTTAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAGC CTGAATGACGAGGGGGAAGGAGAATTCTGGCTAGGCAATGACTACCTCCACTTACTAACCCAAAGGGGCTCTGTTCTTAGGGTTGAATTA GAGGACTGGGCTGGGAATGAAGCTTATGCAGAATATCACTTCCGGGTAGGCTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTAT GAAGGCACTGCGGGTGATGCTCTGATTGAGGGTTCCGTAGAGGAAGGGGCAGAGTACACCTCTCACAACAACATGCAGTTCAGCACCTTT GACAGGGATGCAGACCAGTGGGAAGAGAACTGTGCAGAAGTCTATGGGGGAGGCTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAAT GGAATCTACTACCCTGGGGGCTCCTATGACCCAAGGAATAACAGTCCTTATGAGATTGAGAATGGAGTGGTCTGGGTTTCCTTTAGAGGG GCAGATTATTCCCTCAGGGCTGTTCGCATGAAAATTAGGCCCCTTGTGACCCAATAGGCTGAAGAAGTGGGAATGGGAGCACTCTGTCTT CTTTGCTAGAGAAGTGGAGAGAAAATACAAAAGGTAAAGCAGTTGAGATTCTCTACAACCTAAAAAATTCCTAGGTGCTATTTTCTTATC CTTTGTACTGTAGCTAAATGTACCTGAGACATATTAGTCTTTGAAAAATAAAGTTATGTAAGGTTTTTTTTATCTTTAAATAGCTCTGTG GGTTTTAACATTTTTATAAAGATATACCAAGGGCCATTCAGTACATCAGGAAAGTGGCAGACAGAAGCTTCTCTCTGCAACCTTGAAGAC TATTGGTTTGAGAACTTCTCTTCCCATACCACCCAAAATCATAATGCCATTGGAAAGCAAAAAGTTGTTTTATCCATTTGATTTGAATTG TTTTAAGCCAATATTTTAAGGTAAAACTCACTGAATCTAACCATAGCTGACCTTTGTAGTAGAATTTACAACTTATAATTACAATGCACA ATTTATAATTACAATATGTATTTATGTCTTTTGCTATGGAGCAAATCCAGGAAGGCAAGAGAAACATTCTTTCCTAAATATAAATGAAAA TCTATCCTTTAAACTCTTCCACTAGACGTTGTAATGCACACTTATTTTTTTCCCAAGGAGTAACCAATTTCTTTCTAAAACACATTTAAA ATTTTAAAACTATTTATGAATATTAAAAAAAGACATAATTCACACATTAATAAACAATCTCCCAAGTATTGATTTAACTTCATTTTTCTA ATAATCATAAACTATATTCTGTGACATGCTAATTATTATTAAATGTAAGTCGTTAGTTCGAAAGCCTCTCACTAAGTATGATCTATGCTA TATTCAAAATTCAACCCATTTACTTTGGTCAATATTTGATCTAAGTTGCATCTTTAATCCTGGTGGTCTTGCCTTCTGATTTTTAATTTG >In-frame_ENST00000406595_ENST00000302053_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=885AA_start in transcript=9_stop in transcript=2666 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA DHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLND EGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRD -------------------------------------------------------------- >In-frame_ENST00000406595_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(transcript)=2235nt_BP=120nt AGAAGCCTCCTGGCAGACACTGGAGCCACGATGAAGCCCCCAAGGCCTGTCCGTACCTGCAGCAAAGTTCTCGTCCTGCTTTCACTGCTG GCCATCCACCAGACTACTACTGCCGAAAAGACTGCAGATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAGG GTTGTGGAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGGAACTACAAATGCCCTTCTGGCTGC AGGATGAAAGGGTTGATTGATGAAGTCAATCAAGATTTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAAC AATAAGGATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCCAATAACCGTGATAATACCTACAAC CGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTCCTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAAT GTTAGAGCTCAGTTGGTTGATATGAAACGACTGGAGGTGGACATTGATATTAAGATCCGATCTTGTCGAGGGTCATGCAGTAGGGCTTTA GCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAGCAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGG CAACACTTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAGCTTCAGAAGGTACCCCCAGAGTGG AAGGCATTAACAGACATGCCGCAGATGAGAATGGAGTTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGA ACCGGATCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCTGGACCTGGAAGTACTGGAAACCGA AACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACCTGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGC TCTGGAACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGGAATCCTGGCAGCTCTGAACGCGGA AGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCTGGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCA GGCTCTGGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTAAGTCCAGGGACAAGGAGAGAGTAC CACACAGAAAAACTGGTCACTTCTAAAGGAGATAAAGAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGT CGTTCATGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAAGAAGTGGTGACCTCCGAAGATGGT TCTGACTGTCCCGAGGCAATGGATTTAGGCACATTGTCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCC TTCTTCGACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTTGTCAGTGAGACTGAGTCTAGGGGC TCAGAATCTGGCATCTTCACAAATACAAAGGAATCCAGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGT TACAGCAAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGCTATAAAATGGCAGATGAGGCCGGA AGTGAAGCCGATCATGAAGGAACACATAGCACCAAGAGAGGCCATGCTAAATCTCGCCCTGTCAGAGGTATCCACACTTCTCCTTTGGGG AAGCCTTCCCTGTCCCCCTAGACTAAGTTAAATATTTCTGCACAGTGTTCCCATGGCCCCTTGCATTTCCTTCTTAACTCTCTGTTACAC GTCATTGAAACTACACTTTTTTGGTCTGTTTTTGTGCTAGACTGTAAGTTCCTTGGGGGCAGGGCCTTTGTCTGTCTCATCTCTGTATTC >In-frame_ENST00000406595_ENST00000403106_TCGA-BC-A10Z-11A_ITIH4_chr3_52864569_-_FGA_chr4_155510714_length(amino acids)=663AA_start in transcript=9_stop in transcript=2000 MADTGATMKPPRPVRTCSKVLVLLSLLAIHQTTTAEKTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMK GLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRA QLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKAL TDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGT GSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTE KLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFD TASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ITIH4-FGA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ITIH4-FGA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ITIH4 | Q14624 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Hgene | ITIH4 | Q14624 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Hgene | ITIH4 | Q14624 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Hgene | ITIH4 | Q14624 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Hgene | ITIH4 | Q14624 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Hgene | ITIH4 | Q14624 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Hgene | ITIH4 | Q14624 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
| Hgene | ITIH4 | Q14624 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
| Hgene | ITIH4 | Q14624 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
| Hgene | ITIH4 | Q14624 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
| Hgene | ITIH4 | Q14624 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
| Tgene | FGA | P02671 | DB00009 | Alteplase | Biotech | Approved | |
| Tgene | FGA | P02671 | DB00029 | Anistreplase | Biotech | Approved | |
| Tgene | FGA | P02671 | DB00031 | Tenecteplase | Biotech | Approved | |
| Tgene | FGA | P02671 | DB11311 | Prothrombin | Cleavage | Biotech | Approved |
| Tgene | FGA | P02671 | DB11571 | Human thrombin | Activator | Biotech | Approved |
| Tgene | FGA | P02671 | DB11572 | Thrombin alfa | Activator | Biotech | Approved |
| Tgene | FGA | P02671 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Tgene | FGA | P02671 | DB00015 | Reteplase | Biotech | Approved|Investigational | |
| Tgene | FGA | P02671 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | FGA | P02671 | DB05099 | Ancrod | Biotech | Approved|Investigational | |
| Tgene | FGA | P02671 | DB11300 | Thrombin | Activator | Biotech | Approved|Investigational |
| Tgene | FGA | P02671 | DB13151 | Anti-inhibitor coagulant complex | Cleavage | Biotech | Approved|Investigational |
| Tgene | FGA | P02671 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | FGA | P02671 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
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Related Diseases for ITIH4-FGA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ITIH4 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Hgene | ITIH4 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| Hgene | ITIH4 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | ITIH4 | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human |
| Hgene | ITIH4 | C2713442 | Polyposis, Adenomatous Intestinal | 1 | CTD_human |
| Hgene | ITIH4 | C2713443 | Familial Intestinal Polyposis | 1 | CTD_human |
| Tgene | FGA | C2584774 | Congenital hypofibrinogenemia | 8 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Tgene | FGA | C0272350 | Dysfibrinogenemia, Congenital | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Tgene | FGA | C0001733 | Afibrinogenemia | 4 | CTD_human |
| Tgene | FGA | C4316812 | Fibrinogen Deficiency | 4 | CTD_human;GENOMICS_ENGLAND |
| Tgene | FGA | C0268389 | Amyloidosis, familial visceral | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | FGA | C0022658 | Kidney Diseases | 2 | CTD_human |
| Tgene | FGA | C0740340 | Amyloidosis, Familial | 2 | CTD_human |
| Tgene | FGA | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human |
| Tgene | FGA | C0008370 | Cholestasis | 1 | CTD_human |
| Tgene | FGA | C0013221 | Drug toxicity | 1 | CTD_human |
| Tgene | FGA | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Tgene | FGA | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Tgene | FGA | C0029456 | Osteoporosis | 1 | CTD_human |
| Tgene | FGA | C0029459 | Osteoporosis, Senile | 1 | CTD_human |
| Tgene | FGA | C0034065 | Pulmonary Embolism | 1 | CTD_human |
| Tgene | FGA | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| Tgene | FGA | C0040053 | Thrombosis | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | FGA | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Tgene | FGA | C0087086 | Thrombus | 1 | CTD_human |
| Tgene | FGA | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human |
| Tgene | FGA | C0398623 | Thrombophilia | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | FGA | C0524702 | Pulmonary Thromboembolisms | 1 | CTD_human |
| Tgene | FGA | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human |
| Tgene | FGA | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
| Tgene | FGA | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Tgene | FGA | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Tgene | FGA | C1861172 | Venous Thromboembolism | 1 | CTD_human |
| Tgene | FGA | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Tgene | FGA | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | FGA | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
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