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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ITPR1-SETMAR (FusionGDB2 ID:40508) |
Fusion Gene Summary for ITPR1-SETMAR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ITPR1-SETMAR | Fusion gene ID: 40508 | Hgene | Tgene | Gene symbol | ITPR1 | SETMAR | Gene ID | 3708 | 6419 |
| Gene name | inositol 1,4,5-trisphosphate receptor type 1 | SET domain and mariner transposase fusion gene | |
| Synonyms | ACV|CLA4|INSP3R1|IP3R|IP3R1|PPP1R94|SCA15|SCA16|SCA29 | METNASE|Mar1 | |
| Cytomap | 3p26.1 | 3p26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inositol 1,4,5-trisphosphate receptor type 1IP3 receptorIP3R 1inositol 1,4,5-triphosphate receptor, type 1protein phosphatase 1, regulatory subunit 94type 1 InsP3 receptortype 1 inositol 1,4,5-trisphosphate receptor | histone-lysine N-methyltransferase SETMARSET domain and mariner transposase fusion gene-containing proteinSET domain and mariner transposase fusion protein | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q14643 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000302640, ENST00000354582, ENST00000423119, ENST00000456211, ENST00000357086, ENST00000544951, ENST00000443694, ENST00000463980, | ENST00000358065, ENST00000430981, ENST00000425863, ENST00000462115, | |
| Fusion gene scores | * DoF score | 14 X 15 X 8=1680 | 2 X 3 X 2=12 |
| # samples | 16 | 3 | |
| ** MAII score | log2(16/1680*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ITPR1 [Title/Abstract] AND SETMAR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ITPR1(4695570)-SETMAR(4354582), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ITPR1-SETMAR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ITPR1-SETMAR seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ITPR1 | GO:0001666 | response to hypoxia | 19120137 |
| Hgene | ITPR1 | GO:0050849 | negative regulation of calcium-mediated signaling | 16793548 |
| Tgene | SETMAR | GO:0000729 | DNA double-strand break processing | 21491884 |
| Tgene | SETMAR | GO:0000737 | DNA catabolic process, endonucleolytic | 20521842|21491884 |
| Tgene | SETMAR | GO:0006303 | double-strand break repair via nonhomologous end joining | 16332963 |
| Tgene | SETMAR | GO:0010452 | histone H3-K36 methylation | 16332963 |
| Tgene | SETMAR | GO:0051568 | histone H3-K4 methylation | 16332963 |
| Tgene | SETMAR | GO:2000373 | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity | 18790802 |
| Tgene | SETMAR | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining | 20620605|21491884 |
| Tgene | SETMAR | GO:2001251 | negative regulation of chromosome organization | 20620605 |
| Fusion gene breakpoints across ITPR1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SETMAR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-BP-5195-01A | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| ChimerDB4 | KIRC | TCGA-BP-5195-01A | ITPR1 | chr3 | 4695570 | - | SETMAR | chr3 | 4354582 | + |
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Fusion Gene ORF analysis for ITPR1-SETMAR |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000302640 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000302640 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000302640 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3UTR | ENST00000302640 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000354582 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000354582 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000354582 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000354582 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000423119 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000423119 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000423119 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000423119 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000456211 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000456211 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000456211 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3UTR | ENST00000456211 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000357086 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000357086 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000357086 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000357086 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000544951 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000544951 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000544951 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000544951 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000443694 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000443694 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000443694 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3UTR | ENST00000443694 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000463980 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000463980 | ENST00000430981 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000463980 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| intron-3UTR | ENST00000463980 | ENST00000462115 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000354582 | ITPR1 | chr3 | 4695570 | + | ENST00000358065 | SETMAR | chr3 | 4354582 | + | 3566 | 1346 | 305 | 3244 | 979 |
| ENST00000354582 | ITPR1 | chr3 | 4695570 | + | ENST00000425863 | SETMAR | chr3 | 4354582 | + | 2847 | 1346 | 305 | 2827 | 840 |
| ENST00000423119 | ITPR1 | chr3 | 4695570 | + | ENST00000358065 | SETMAR | chr3 | 4354582 | + | 3566 | 1346 | 305 | 3244 | 979 |
| ENST00000423119 | ITPR1 | chr3 | 4695570 | + | ENST00000425863 | SETMAR | chr3 | 4354582 | + | 2847 | 1346 | 305 | 2827 | 840 |
| ENST00000357086 | ITPR1 | chr3 | 4695570 | + | ENST00000358065 | SETMAR | chr3 | 4354582 | + | 3564 | 1344 | 303 | 3242 | 979 |
| ENST00000357086 | ITPR1 | chr3 | 4695570 | + | ENST00000425863 | SETMAR | chr3 | 4354582 | + | 2845 | 1344 | 303 | 2825 | 840 |
| ENST00000544951 | ITPR1 | chr3 | 4695570 | + | ENST00000358065 | SETMAR | chr3 | 4354582 | + | 3364 | 1144 | 103 | 3042 | 979 |
| ENST00000544951 | ITPR1 | chr3 | 4695570 | + | ENST00000425863 | SETMAR | chr3 | 4354582 | + | 2645 | 1144 | 103 | 2625 | 840 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000354582 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000230434 | 0.9997696 |
| ENST00000354582 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000999328 | 0.9990007 |
| ENST00000423119 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000230434 | 0.9997696 |
| ENST00000423119 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000999328 | 0.9990007 |
| ENST00000357086 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000223976 | 0.99977607 |
| ENST00000357086 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000973822 | 0.9990262 |
| ENST00000544951 | ENST00000358065 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.000265812 | 0.9997342 |
| ENST00000544951 | ENST00000425863 | ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354582 | + | 0.001060414 | 0.9989396 |
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Fusion Genomic Features for ITPR1-SETMAR |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354581 | + | 0.002074482 | 0.9979255 |
| ITPR1 | chr3 | 4695570 | + | SETMAR | chr3 | 4354581 | + | 0.002074482 | 0.9979255 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ITPR1-SETMAR |
| Go to FGviewer for the breakpoints of chr3:4695570-chr3:4354582 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ITPR1 | . |
| FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000269|PubMed:27108797}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 112_166 | 332.0 | 2711.0 | Domain | MIR 1 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 173_223 | 332.0 | 2711.0 | Domain | MIR 2 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 231_287 | 332.0 | 2711.0 | Domain | MIR 3 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 265_269 | 332.0 | 2711.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 364_395 | 52.0 | 685.0 | DNA binding | H-T-H motif | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 428_448 | 52.0 | 685.0 | DNA binding | Note=H-T-H motif | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 139_263 | 52.0 | 685.0 | Domain | SET | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 283_299 | 52.0 | 685.0 | Domain | Post-SET | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 73_136 | 52.0 | 685.0 | Domain | Pre-SET | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 149_151 | 52.0 | 685.0 | Region | Note=S-adenosyl-L-methionine binding | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 223_224 | 52.0 | 685.0 | Region | Note=S-adenosyl-L-methionine binding | |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 346_684 | 52.0 | 685.0 | Region | Note=Mariner transposase Hsmar1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 112_166 | 0 | 2744.0 | Domain | MIR 1 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 173_223 | 0 | 2744.0 | Domain | MIR 2 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 231_287 | 0 | 2744.0 | Domain | MIR 3 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 294_373 | 0 | 2744.0 | Domain | MIR 4 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 379_435 | 0 | 2744.0 | Domain | MIR 5 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 294_373 | 332.0 | 2711.0 | Domain | MIR 4 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 379_435 | 332.0 | 2711.0 | Domain | MIR 5 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 112_166 | 0.0 | 2744.0 | Domain | MIR 1 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 173_223 | 0.0 | 2744.0 | Domain | MIR 2 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 231_287 | 0.0 | 2744.0 | Domain | MIR 3 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 294_373 | 0.0 | 2744.0 | Domain | MIR 4 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 379_435 | 0.0 | 2744.0 | Domain | MIR 5 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 112_166 | 0 | 2696.0 | Domain | MIR 1 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 173_223 | 0 | 2696.0 | Domain | MIR 2 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 231_287 | 0 | 2696.0 | Domain | MIR 3 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 294_373 | 0 | 2696.0 | Domain | MIR 4 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 379_435 | 0 | 2696.0 | Domain | MIR 5 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 265_269 | 0 | 2744.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 508_511 | 0 | 2744.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 567_569 | 0 | 2744.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 508_511 | 332.0 | 2711.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 567_569 | 332.0 | 2711.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 265_269 | 0.0 | 2744.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 508_511 | 0.0 | 2744.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 567_569 | 0.0 | 2744.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 265_269 | 0 | 2696.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 508_511 | 0 | 2696.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 567_569 | 0 | 2696.0 | Region | Inositol 1%2C4%2C5-trisphosphate binding |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 1_2282 | 0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2304_2314 | 0 | 2744.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2336_2361 | 0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2383_2405 | 0 | 2744.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2427_2448 | 0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2470_2577 | 0 | 2744.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2599_2758 | 0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 1_2282 | 332.0 | 2711.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2304_2314 | 332.0 | 2711.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2336_2361 | 332.0 | 2711.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2383_2405 | 332.0 | 2711.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2427_2448 | 332.0 | 2711.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2470_2577 | 332.0 | 2711.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2599_2758 | 332.0 | 2711.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 1_2282 | 0.0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2304_2314 | 0.0 | 2744.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2336_2361 | 0.0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2383_2405 | 0.0 | 2744.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2427_2448 | 0.0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2470_2577 | 0.0 | 2744.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2599_2758 | 0.0 | 2744.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 1_2282 | 0 | 2696.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2304_2314 | 0 | 2696.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2336_2361 | 0 | 2696.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2383_2405 | 0 | 2696.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2427_2448 | 0 | 2696.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2470_2577 | 0 | 2696.0 | Topological domain | Lumenal |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2599_2758 | 0 | 2696.0 | Topological domain | Cytoplasmic |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2283_2303 | 0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2315_2335 | 0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2362_2382 | 0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2406_2426 | 0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2449_2469 | 0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2578_2598 | 0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2283_2303 | 332.0 | 2711.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2315_2335 | 332.0 | 2711.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2362_2382 | 332.0 | 2711.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2406_2426 | 332.0 | 2711.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2449_2469 | 332.0 | 2711.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2578_2598 | 332.0 | 2711.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2283_2303 | 0.0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2315_2335 | 0.0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2362_2382 | 0.0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2406_2426 | 0.0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2449_2469 | 0.0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2578_2598 | 0.0 | 2744.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2283_2303 | 0 | 2696.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2315_2335 | 0 | 2696.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2362_2382 | 0 | 2696.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2406_2426 | 0 | 2696.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2449_2469 | 0 | 2696.0 | Transmembrane | Helical |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2578_2598 | 0 | 2696.0 | Transmembrane | Helical |
| Tgene | SETMAR | chr3:4695570 | chr3:4354582 | ENST00000358065 | 0 | 3 | 1_345 | 52.0 | 685.0 | Region | Note=Histone-lysine N-methyltransferase |
Top |
Fusion Gene Sequence for ITPR1-SETMAR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000354582_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=3566nt_BP=1346nt GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACA CTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCC CTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGC CTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGT TCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAG GATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGC AGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTC CTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAG GAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCAT GTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGT GTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAAATGATGTTAGACAAAAAGCAAATTCGAGCAA TTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCAACAATGCATTTGGCCCAGGAACTGCTAACGAAC GTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATGAGGAGCGTAGTGGCCGGCCATCAGAAGTTGACA ACGACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCTGAAGAACTCAATGTCAACCATTCTACGGTCG TTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAGCTGACTGAAAATCAAAAAAATCGTCGTTTTG AAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTGTGACGTGTGATGAAAAGTGGATTTTATATGACA ACCGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAAAGCCAATCTTGCACCCAAAAAAGGTCATGGTCA CTATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACCATTACATCTGAGAAGTATGCTCAGGAAATCG ATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCCCAATTCTTCTCCACGACAATGCCCGACCGCATG TTGCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATCCACCGTATTCACCTGACCTCTTGCCAACCAACT ACCACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAGGATGCAGAAAATGCTTTCCAAGAGTTCGTCG AATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAAAAATGTGTTGATTGTAATGGTTCCTATTTTG ATTAATAAAAATGCGTTGAGCCTAGTTATAATGATTTAAAATTCACAGTCCAAAACCGCAGTTAGTTTTGCACCAACCCAATATCTTCAT AGATTGAAATATAAATTAAAATTGCATTTGAAGTAGATTCCACGGACTTTATTAAGAATGTAGAAATGTGGCCTGGCATGGTGGCTTACA ACTGTAATCCCAGCACTTTGGGAGGCCCAGGCGGGCAGATCACTTGAGTCCAATTGTTCAGGACCAGCCTGGGCAACATAGTGAGACCCT >In-frame_ENST00000354582_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=979AA_start in transcript=305_stop in transcript=3244 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLA LFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCK RLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADP LTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQE EAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNEL -------------------------------------------------------------- >In-frame_ENST00000354582_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=2847nt_BP=1346nt GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACA CTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCC CTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGC CTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGT TCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACA TCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGA AAATGATGTTAGACAAAAAGCAAATTCGAGCAATTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCA ACAATGCATTTGGCCCAGGAACTGCTAACGAACGTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATG AGGAGCGTAGTGGCCGGCCATCAGAAGTTGACAACGACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTG CTGAAGAACTCAATGTCAACCATTCTACGGTCGTTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATG AGCTGACTGAAAATCAAAAAAATCGTCGTTTTGAAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTG TGACGTGTGATGAAAAGTGGATTTTATATGACAACCGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAA AGCCAATCTTGCACCCAAAAAAGGTCATGGTCACTATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAA CCATTACATCTGAGAAGTATGCTCAGGAAATCGATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCC CAATTCTTCTCCACGACAATGCCCGACCGCATGTTGCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATC CACCGTATTCACCTGACCTCTTGCCAACCAACTACCACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGC AGGATGCAGAAAATGCTTTCCAAGAGTTCGTCGAATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGC >In-frame_ENST00000354582_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=840AA_start in transcript=305_stop in transcript=2827 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANER TVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFE VSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEID EMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVE -------------------------------------------------------------- >In-frame_ENST00000423119_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=3566nt_BP=1346nt GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACA CTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCC CTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGC CTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGT TCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAG GATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGC AGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTC CTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAG GAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCAT GTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGT GTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAAATGATGTTAGACAAAAAGCAAATTCGAGCAA TTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCAACAATGCATTTGGCCCAGGAACTGCTAACGAAC GTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATGAGGAGCGTAGTGGCCGGCCATCAGAAGTTGACA ACGACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCTGAAGAACTCAATGTCAACCATTCTACGGTCG TTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAGCTGACTGAAAATCAAAAAAATCGTCGTTTTG AAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTGTGACGTGTGATGAAAAGTGGATTTTATATGACA ACCGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAAAGCCAATCTTGCACCCAAAAAAGGTCATGGTCA CTATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACCATTACATCTGAGAAGTATGCTCAGGAAATCG ATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCCCAATTCTTCTCCACGACAATGCCCGACCGCATG TTGCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATCCACCGTATTCACCTGACCTCTTGCCAACCAACT ACCACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAGGATGCAGAAAATGCTTTCCAAGAGTTCGTCG AATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAAAAATGTGTTGATTGTAATGGTTCCTATTTTG ATTAATAAAAATGCGTTGAGCCTAGTTATAATGATTTAAAATTCACAGTCCAAAACCGCAGTTAGTTTTGCACCAACCCAATATCTTCAT AGATTGAAATATAAATTAAAATTGCATTTGAAGTAGATTCCACGGACTTTATTAAGAATGTAGAAATGTGGCCTGGCATGGTGGCTTACA ACTGTAATCCCAGCACTTTGGGAGGCCCAGGCGGGCAGATCACTTGAGTCCAATTGTTCAGGACCAGCCTGGGCAACATAGTGAGACCCT >In-frame_ENST00000423119_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=979AA_start in transcript=305_stop in transcript=3244 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLA LFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCK RLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADP LTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQE EAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNEL -------------------------------------------------------------- >In-frame_ENST00000423119_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=2847nt_BP=1346nt GCAGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGG AGGCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGG ACATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACA GAGGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACA AAATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTG ATGATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGA ACCGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACC ACGCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCC TGCATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGG CTGGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTC TGAACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACT GCAATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTC ATGCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACAT CTGCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCC GTTTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACA CTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCC CTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGC CTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGT TCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACA TCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGA AAATGATGTTAGACAAAAAGCAAATTCGAGCAATTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCA ACAATGCATTTGGCCCAGGAACTGCTAACGAACGTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATG AGGAGCGTAGTGGCCGGCCATCAGAAGTTGACAACGACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTG CTGAAGAACTCAATGTCAACCATTCTACGGTCGTTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATG AGCTGACTGAAAATCAAAAAAATCGTCGTTTTGAAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTG TGACGTGTGATGAAAAGTGGATTTTATATGACAACCGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAA AGCCAATCTTGCACCCAAAAAAGGTCATGGTCACTATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAA CCATTACATCTGAGAAGTATGCTCAGGAAATCGATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCC CAATTCTTCTCCACGACAATGCCCGACCGCATGTTGCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATC CACCGTATTCACCTGACCTCTTGCCAACCAACTACCACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGC AGGATGCAGAAAATGCTTTCCAAGAGTTCGTCGAATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGC >In-frame_ENST00000423119_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=840AA_start in transcript=305_stop in transcript=2827 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANER TVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFE VSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEID EMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVE -------------------------------------------------------------- >In-frame_ENST00000357086_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=3564nt_BP=1344nt AGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGGAG GCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGGAC ATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGA GGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAA ATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGAT GATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAAC CGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCAC GCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTG CATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCT GGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTG AACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGC AATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCAT GCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCT GCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGT TTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACACT CCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCT GGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCT GTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTC AAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGA TTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAG GTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCT GTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGA AGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGT ACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGT GGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAAATGATGTTAGACAAAAAGCAAATTCGAGCAATT TTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCAACAATGCATTTGGCCCAGGAACTGCTAACGAACGT ACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATGAGGAGCGTAGTGGCCGGCCATCAGAAGTTGACAAC GACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCTGAAGAACTCAATGTCAACCATTCTACGGTCGTT CGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAGCTGACTGAAAATCAAAAAAATCGTCGTTTTGAA GTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTGTGACGTGTGATGAAAAGTGGATTTTATATGACAAC CGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAAAGCCAATCTTGCACCCAAAAAAGGTCATGGTCACT ATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACCATTACATCTGAGAAGTATGCTCAGGAAATCGAT GAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCCCAATTCTTCTCCACGACAATGCCCGACCGCATGTT GCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATCCACCGTATTCACCTGACCTCTTGCCAACCAACTAC CACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAGGATGCAGAAAATGCTTTCCAAGAGTTCGTCGAA TCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAAAAATGTGTTGATTGTAATGGTTCCTATTTTGAT TAATAAAAATGCGTTGAGCCTAGTTATAATGATTTAAAATTCACAGTCCAAAACCGCAGTTAGTTTTGCACCAACCCAATATCTTCATAG ATTGAAATATAAATTAAAATTGCATTTGAAGTAGATTCCACGGACTTTATTAAGAATGTAGAAATGTGGCCTGGCATGGTGGCTTACAAC TGTAATCCCAGCACTTTGGGAGGCCCAGGCGGGCAGATCACTTGAGTCCAATTGTTCAGGACCAGCCTGGGCAACATAGTGAGACCCTGA >In-frame_ENST00000357086_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=979AA_start in transcript=303_stop in transcript=3242 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLA LFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCK RLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADP LTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQE EAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNEL -------------------------------------------------------------- >In-frame_ENST00000357086_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=2845nt_BP=1344nt AGTAACCATGTGGATGTGCTGCTGAAGCGTTTCCTCAAGCTCGCTGGGGTGGGAGGAGAGGAGGAGGAGGAGGTGGTGGTGGAGGAGGAG GCAGGGGGTGGAGAGAGAGAAAGCGCACGCCGAGAGGAGGTGTGGGTGTTCCGCTTCCATCCTAACGGAACGAGCTCCCTCTTCGCGGAC ATGGGATTACCCAGCGGCTGCTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGA GGAGCAGGATTTGCACCCCTCGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAA ATGTCTAGCTTCCTACATATTGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGAT GATCGTTGTGTTGTACAGCCAGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAAC CGCTACTCTGCCCAAAAGCAGTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCAC GCTGCAGACTTGGAAAAGAAGCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTG CATTTGAAAAGTAATAAATACCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCT GGAAATGAAGGGTCCTGGTTTTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTG AACCCCGTCAATGCTGGTCAGCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGC AATACAAGCTGGAAAATAGTCCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCAT GCTGAGCAGGAGAAGTTTCTCACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCT GCCACCAGTTCAAAAGCCCTGTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGT TTCAAGCATCTGGCCACGGGGCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACACT CCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCT GGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCT GTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTC AAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATC AGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAA ATGATGTTAGACAAAAAGCAAATTCGAGCAATTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCAAC AATGCATTTGGCCCAGGAACTGCTAACGAACGTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATGAG GAGCGTAGTGGCCGGCCATCAGAAGTTGACAACGACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCT GAAGAACTCAATGTCAACCATTCTACGGTCGTTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAG CTGACTGAAAATCAAAAAAATCGTCGTTTTGAAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTGTG ACGTGTGATGAAAAGTGGATTTTATATGACAACCGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAAAG CCAATCTTGCACCCAAAAAAGGTCATGGTCACTATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACC ATTACATCTGAGAAGTATGCTCAGGAAATCGATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCCCA ATTCTTCTCCACGACAATGCCCGACCGCATGTTGCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATCCA CCGTATTCACCTGACCTCTTGCCAACCAACTACCACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAG GATGCAGAAAATGCTTTCCAAGAGTTCGTCGAATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAA >In-frame_ENST00000357086_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=840AA_start in transcript=303_stop in transcript=2825 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANER TVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFE VSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEID EMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVE -------------------------------------------------------------- >In-frame_ENST00000544951_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=3364nt_BP=1144nt CTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGAGGAGCAGGATTTGCACCCCT CGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAAATGTCTAGCTTCCTACATAT TGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGATGATCGTTGTGTTGTACAGCC AGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAACCGCTACTCTGCCCAAAAGCA GTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCACGCTGCAGACTTGGAAAAGAA GCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTGCATTTGAAAAGTAATAAATA CCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCTGGAAATGAAGGGTCCTGGTT TTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTGAACCCCGTCAATGCTGGTCA GCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGCAATACAAGCTGGAAAATAGT CCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCATGCTGAGCAGGAGAAGTTTCT CACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCTGCCACCAGTTCAAAAGCCCT GTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGTTTCAAGCATCTGGCCACGGG GCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACACTCCTGATCATGTAGTTGGACC TGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCG CCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCT GTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTG GGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAG AATTCACTTACAAACAAAATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGA CCCTACTTATATAGGAAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGT ACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGT CAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGA CAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTT CCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAAATGATGTTAGACAAAAAGCAAATTCGAGCAATTTTCTTATTCGAGTTCAAAAT GGGTCGTAAAGCAGCAGAAACAACTCGCAACATCAACAATGCATTTGGCCCAGGAACTGCTAACGAACGTACAGTGCAGTGGTGGTTCAA GAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATGAGGAGCGTAGTGGCCGGCCATCAGAAGTTGACAACGACCAGTTGAGAGCAATCAT CGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCTGAAGAACTCAATGTCAACCATTCTACGGTCGTTCGACATTTGAAGCAAATTGG AAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAGCTGACTGAAAATCAAAAAAATCGTCGTTTTGAAGTGTCATCTTCTCTTATTCT ACGCAACCACAACGAACCATTTCTCGATCGGATTGTGACGTGTGATGAAAAGTGGATTTTATATGACAACCGGCGACGATCAGCTCAGTG GTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAAAGCCAATCTTGCACCCAAAAAAGGTCATGGTCACTATTTGGTGGTCTGCTGCTGG TCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACCATTACATCTGAGAAGTATGCTCAGGAAATCGATGAGATGAACCAAAAACTGCA ACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCCCAATTCTTCTCCACGACAATGCCCGACCGCATGTTGCACAACCCACACTTCAAAA GTTGAATGAATTGGGCTATGAAGTTTTGCCTCATCCACCGTATTCACCTGACCTCTTGCCAACCAACTACCACGTCTTTAAGCATCTCAA CAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAGGATGCAGAAAATGCTTTCCAAGAGTTCGTCGAATCCCAAAGCACGGATTTTTA CGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAAAAATGTGTTGATTGTAATGGTTCCTATTTTGATTAATAAAAATGCGTTGAGCC TAGTTATAATGATTTAAAATTCACAGTCCAAAACCGCAGTTAGTTTTGCACCAACCCAATATCTTCATAGATTGAAATATAAATTAAAAT TGCATTTGAAGTAGATTCCACGGACTTTATTAAGAATGTAGAAATGTGGCCTGGCATGGTGGCTTACAACTGTAATCCCAGCACTTTGGG AGGCCCAGGCGGGCAGATCACTTGAGTCCAATTGTTCAGGACCAGCCTGGGCAACATAGTGAGACCCTGACTCTAATAAAATAATTTTTT >In-frame_ENST00000544951_ENST00000358065_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=979AA_start in transcript=103_stop in transcript=3042 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLA LFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCK RLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADP LTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQE EAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNEL -------------------------------------------------------------- >In-frame_ENST00000544951_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(transcript)=2645nt_BP=1144nt CTAACCCCTCTCCTCGCCCTGCTCCCCCAAACCGGCGTGGCTCCCCGGGCACCAAGGAGCTGACTACAGAGGAGCAGGATTTGCACCCCT CGCTGGGCTTGCTTTGGCAACAGAGTGCCTGACCCAGGTCAGGATTTTCAAGAAAGACATGTCTGACAAAATGTCTAGCTTCCTACATAT TGGAGACATTTGTTCTCTGTACGCGGAGGGATCGACAAATGGATTTATTAGCACCTTGGGCCTGGTTGATGATCGTTGTGTTGTACAGCC AGAAACCGGGGACCTTAACAATCCACCTAAGAAATTCAGAGACTGCCTCTTTAAGCTATGTCCCATGAACCGCTACTCTGCCCAAAAGCA GTTCTGGAAAGCCGCTAAGCCTGGGGCCAACAGCACCACAGACGCAGTGCTACTCAACAAACTGCACCACGCTGCAGACTTGGAAAAGAA GCAGAATGAGACAGAAAACAGGAAATTGCTGGGGACCGTAATCCAGTATGGCAATGTGATCCAGCTCCTGCATTTGAAAAGTAATAAATA CCTAACAGTGAATAAGAGGCTTCCTGCTCTGTTGGAGAAGAATGCCATGAGAGTCACATTGGACGAGGCTGGAAATGAAGGGTCCTGGTT TTATATTCAGCCATTCTACAAGCTGCGATCCATTGGAGACAGCGTGGTCATAGGTGACAAGGTGGTTCTGAACCCCGTCAATGCTGGTCA GCCCCTACATGCTAGCAGCCATCAACTGGTAGATAACCCAGGCTGCAATGAGGTCAATTCCGTCAACTGCAATACAAGCTGGAAAATAGT CCTTTTCATGAAATGGAGTGATAACAAAGACGACATATTAAAGGGGGGTGACGTGGTGAGGCTGTTTCATGCTGAGCAGGAGAAGTTTCT CACCTGTGACGAACACAGGAAGAAGCAGCACGTCTTCCTGAGAACCACGGGCCGGCAGTCGGCCACATCTGCCACCAGTTCAAAAGCCCT GTGGGAGGTGGAGGTGGTCCAGCATGACCCATGTCGGGGCGGAGCAGGGTATTGGAACAGCCTTTTCCGTTTCAAGCATCTGGCCACGGG GCATTACTTGGCAGCAGAGGTAGACCCTGACTTTGAGGAAGAATGCCTGGAGTTTCAGCCCTCATACACTCCTGATCATGTAGTTGGACC TGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCG CCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCT GTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTG GGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGA ACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGACTATGAAAATGATGTTAGACAAAAAGCA AATTCGAGCAATTTTCTTATTCGAGTTCAAAATGGGTCGTAAAGCAGCAGAAACAACTCGCAACATCAACAATGCATTTGGCCCAGGAAC TGCTAACGAACGTACAGTGCAGTGGTGGTTCAAGAAGTTTTGCAAAGGAGATGAGAGCCTTGAAGATGAGGAGCGTAGTGGCCGGCCATC AGAAGTTGACAACGACCAGTTGAGAGCAATCATCGAAGCTGATCCCCTTACAACTACACGAGAAGTTGCTGAAGAACTCAATGTCAACCA TTCTACGGTCGTTCGACATTTGAAGCAAATTGGAAAGGTGAAAAAGCTCGATAAGTGGGTGCCTCATGAGCTGACTGAAAATCAAAAAAA TCGTCGTTTTGAAGTGTCATCTTCTCTTATTCTACGCAACCACAACGAACCATTTCTCGATCGGATTGTGACGTGTGATGAAAAGTGGAT TTTATATGACAACCGGCGACGATCAGCTCAGTGGTTGGATCAAGAAGAAGCTCCAAAGCACTTCCCAAAGCCAATCTTGCACCCAAAAAA GGTCATGGTCACTATTTGGTGGTCTGCTGCTGGTCTGATCCACTACAGCTTTCTGAATCCCGGTGAAACCATTACATCTGAGAAGTATGC TCAGGAAATCGATGAGATGAACCAAAAACTGCAACGCCTGCAGCTGGCATTGGTCAACAGAAAGGGCCCAATTCTTCTCCACGACAATGC CCGACCGCATGTTGCACAACCCACACTTCAAAAGTTGAATGAATTGGGCTATGAAGTTTTGCCTCATCCACCGTATTCACCTGACCTCTT GCCAACCAACTACCACGTCTTTAAGCATCTCAACAACTTTTTGCAGGGAAAACGCTTCCACAACCAGCAGGATGCAGAAAATGCTTTCCA AGAGTTCGTCGAATCCCAAAGCACGGATTTTTACGCTACAGGAATAAACCAACTTATTTCTCGTTGGCAAAAATGTGTTGATTGTAATGG >In-frame_ENST00000544951_ENST00000425863_TCGA-BP-5195-01A_ITPR1_chr3_4695570_+_SETMAR_chr3_4354582_length(amino acids)=840AA_start in transcript=103_stop in transcript=2625 MATECLTQVRIFKKDMSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKA AKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQP FYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDE HRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSYTPDHVVGPGADI DPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRT LEFIPKGSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANER TVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFE VSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEID EMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ITPR1-SETMAR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000302640 | + | 1 | 61 | 2472_2537 | 0 | 2744.0 | ERP44 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000357086 | + | 12 | 59 | 2472_2537 | 332.0 | 2711.0 | ERP44 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000443694 | + | 1 | 59 | 2472_2537 | 0.0 | 2744.0 | ERP44 |
| Hgene | ITPR1 | chr3:4695570 | chr3:4354582 | ENST00000456211 | + | 1 | 58 | 2472_2537 | 0 | 2696.0 | ERP44 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ITPR1-SETMAR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ITPR1 | Q14643 | DB09462 | Glycerin | Small molecule | Approved|Investigational | |
| Hgene | ITPR1 | Q14643 | DB09462 | Glycerin | Small molecule | Approved|Investigational |
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Related Diseases for ITPR1-SETMAR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ITPR1 | C1847725 | SPINOCEREBELLAR ATAXIA 15 | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | ITPR1 | C0431401 | Gillespie syndrome | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | ITPR1 | C1861732 | SPINOCEREBELLAR ATAXIA 29 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | ITPR1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | ITPR1 | C0003132 | Anoxic Encephalopathy | 1 | CTD_human |
| Hgene | ITPR1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Hgene | ITPR1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ITPR1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | ITPR1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Hgene | ITPR1 | C0995195 | Anoxia of brain | 1 | CTD_human |
| Hgene | ITPR1 | C1140716 | Hypoxic Brain Damage | 1 | CTD_human |
| Hgene | ITPR1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Hgene | ITPR1 | C1527348 | Brain Hypoxia | 1 | CTD_human |
| Hgene | ITPR1 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
| Hgene | ITPR1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Hgene | ITPR1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Hgene | ITPR1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
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