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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ITPR2-KIAA0922 (FusionGDB2 ID:40522)

Fusion Gene Summary for ITPR2-KIAA0922

check button Fusion gene summary
Fusion gene informationFusion gene name: ITPR2-KIAA0922
Fusion gene ID: 40522
HgeneTgene
Gene symbol

ITPR2

KIAA0922

Gene ID

3709

23240

Gene nameinositol 1,4,5-trisphosphate receptor type 2transmembrane 131 like
SynonymsANHD|CFAP48|INSP3R2|IP3R2KIAA0922
Cytomap

12p11.23

4q31.3

Type of geneprotein-codingprotein-coding
Descriptioninositol 1,4,5-trisphosphate receptor type 2IP3 receptorIP3R 2cilia and flagella associated protein 48type 2 InsP3 receptortransmembrane protein 131-like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000381340, ENST00000545902, 
ENST00000242737, 		ENST00000440693, 
ENST00000409663, ENST00000409959, 
Fusion gene scores* DoF score21 X 18 X 10=37803 X 4 X 3=36
# samples 234
** MAII scorelog2(23/3780*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ITPR2 [Title/Abstract] AND KIAA0922 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointITPR2(26774055)-KIAA0922(154501977), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITPR2

GO:0001666

response to hypoxia

19120137

TgeneKIAA0922

GO:0090090

negative regulation of canonical Wnt signaling pathway

23690469


check buttonFusion gene breakpoints across ITPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KIAA0922 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4ONITPR2chr12

26774055

-KIAA0922chr4

154501977

+
ChimerDB4ESCATCGA-L5-A4ONITPR2chr12

26774055

-KIAA0922chr4

154501977

+


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Fusion Gene ORF analysis for ITPR2-KIAA0922

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000381340ENST00000440693ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
In-frameENST00000381340ENST00000409663ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
In-frameENST00000381340ENST00000409959ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
intron-3CDSENST00000545902ENST00000440693ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
intron-3CDSENST00000545902ENST00000409663ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
intron-3CDSENST00000545902ENST00000409959ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
intron-3CDSENST00000242737ENST00000440693ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
intron-3CDSENST00000242737ENST00000409663ITPR2chr12

26774055

-KIAA0922chr4

154501977

+
intron-3CDSENST00000242737ENST00000409959ITPR2chr12

26774055

-KIAA0922chr4

154501977

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381340ITPR2chr1226774055-ENST00000440693KIAA0922chr4154501977+7932387941777992460
ENST00000381340ITPR2chr1226774055-ENST00000409663KIAA0922chr4154501977+8184387941780482543
ENST00000381340ITPR2chr1226774055-ENST00000409959KIAA0922chr4154501977+8187387941780512544

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381340ENST00000440693ITPR2chr1226774055-KIAA0922chr4154501977+0.0014011930.99859875
ENST00000381340ENST00000409663ITPR2chr1226774055-KIAA0922chr4154501977+0.0011682540.9988318
ENST00000381340ENST00000409959ITPR2chr1226774055-KIAA0922chr4154501977+0.0011897660.9988103

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Fusion Genomic Features for ITPR2-KIAA0922


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ITPR2chr1226774055-KIAA0922chr4154501977+3.05E-050.9999695
ITPR2chr1226774055-KIAA0922chr4154501977+3.05E-050.9999695

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ITPR2-KIAA0922


check button Go to

FGviewer for the breakpoints of chr12:26774055-chr4:154501977

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657112_1661154.02702.0DomainMIR 1
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657173_2231154.02702.0DomainMIR 2
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657231_2871154.02702.0DomainMIR 3
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657294_3721154.02702.0DomainMIR 4
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657378_4341154.02702.0DomainMIR 5
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657265_2691154.02702.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657507_5101154.02702.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-2657567_5691154.02702.0RegionInositol 1%2C4%2C5-trisphosphate binding
TgeneKIAA0922chr12:26774055chr4:154501977ENST000004096636351302_1331220.01610.0Compositional biasNote=Ser-rich
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409663635910_913220.01610.0Compositional biasNote=Poly-Ser
TgeneKIAA0922chr12:26774055chr4:154501977ENST000004099596351302_1331220.01611.0Compositional biasNote=Ser-rich
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409959635910_913220.01611.0Compositional biasNote=Poly-Ser
TgeneKIAA0922chr12:26774055chr4:154501977ENST000004406936331302_1331220.01527.0Compositional biasNote=Ser-rich
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000440693633910_913220.01527.0Compositional biasNote=Poly-Ser
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409663635696_916220.01610.0RegionRequired for Wnt-signaling inhibition and LRP6 degradation
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409959635696_916220.01611.0RegionRequired for Wnt-signaling inhibition and LRP6 degradation
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000440693633696_916220.01527.0RegionRequired for Wnt-signaling inhibition and LRP6 degradation
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409663635891_1609220.01610.0Topological domainCytoplasmic
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409959635891_1609220.01611.0Topological domainCytoplasmic
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000440693633891_1609220.01527.0Topological domainCytoplasmic
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409663635870_890220.01610.0TransmembraneHelical
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000409959635870_890220.01611.0TransmembraneHelical
TgeneKIAA0922chr12:26774055chr4:154501977ENST00000440693633870_890220.01527.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16112_1660.0182.0DomainMIR 1
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16173_2230.0182.0DomainMIR 2
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16231_2870.0182.0DomainMIR 3
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16294_3720.0182.0DomainMIR 4
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16378_4340.0182.0DomainMIR 5
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16265_2690.0182.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16507_5100.0182.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-16567_5690.0182.0RegionInositol 1%2C4%2C5-trisphosphate binding
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-161_22270.0182.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162249_22600.0182.0Topological domainExtracellular
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162282_23070.0182.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162329_23510.0182.0Topological domainExtracellular
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162373_23940.0182.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162416_25210.0182.0Topological domainExtracellular
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162543_27010.0182.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26571_22271154.02702.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572249_22601154.02702.0Topological domainExtracellular
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572282_23071154.02702.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572329_23511154.02702.0Topological domainExtracellular
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572373_23941154.02702.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572416_25211154.02702.0Topological domainExtracellular
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572543_27011154.02702.0Topological domainCytoplasmic
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162228_22480.0182.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162261_22810.0182.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162308_23280.0182.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162352_23720.0182.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162395_24150.0182.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000242737-162522_25420.0182.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572228_22481154.02702.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572261_22811154.02702.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572308_23281154.02702.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572352_23721154.02702.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572395_24151154.02702.0TransmembraneHelical
HgeneITPR2chr12:26774055chr4:154501977ENST00000381340-26572522_25421154.02702.0TransmembraneHelical
TgeneKIAA0922chr12:26774055chr4:154501977ENST0000040966363541_869220.01610.0Topological domainExtracellular
TgeneKIAA0922chr12:26774055chr4:154501977ENST0000040995963541_869220.01611.0Topological domainExtracellular
TgeneKIAA0922chr12:26774055chr4:154501977ENST0000044069363341_869220.01527.0Topological domainExtracellular


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Fusion Gene Sequence for ITPR2-KIAA0922


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000381340_ENST00000440693_TCGA-L5-A4ON_ITPR2_chr12_26774055_-_KIAA0922_chr4_154501977_length(transcript)=7932nt_BP=3879nt
CTTCCAGCTCCCGCCGGGCGGCTGTGACGGCCGCAGCGGGTCGCAGAGCAGGGAGTGGACACGGAGTGGGGAGCGGAGAGGGAAGGAGGA
GGAGGAGGAGCAAAGGTGTTGGAGAGAAAACTTCAGAAAGGAACAGGAAACCTGCCGGGGAGGCGGCGGCGGCTGCGGCTTCTCTGGGCG
CCTGGGCTGCGCTCTTCGCGGGGTGTCCGCAGCTGCGGCTTGGCCCCGGTCTGGCTTCCCCGGCGCGCACGCACGGCTGAGCCGCGACGC
TCAGTGGCTCGGGCCGTGCCCTCCGCCGCGGCTCTTGGCCGCTGTAGTCCCGCGATCCGATCCGCTTCTGCCGCGGCGGCTCCCTGGAGA
GAGGGCGGCGAGGGCGCAGGGAAGAAGAGGGACGTCCACTGTGGAACATGAAGCAGCATGACTGAGAAAATGTCCAGCTTCCTCTACATA
GGGGACATCGTGTCCCTGTACGCGGAGGGCTCGGTCAACGGCTTCATCAGCACCTTGGGGTTAGTGGATGACAGATGTGTGGTGCACCCA
GAGGCCGGGGACCTTGCCAACCCTCCCAAGAAGTTCAGAGACTGCCTTTTCAAGGTGTGCCCTATGAACAGATATTCTGCCCAGAAGCAA
TATTGGAAAGCAAAGCAAGCCAAACAAGGGAACCACACCGAGGCAGCCTTGCTGAAGAAACTACAGCACGCTGCAGAACTGGAACAAAAA
CAAAATGAATCGGAGAATAAGAAACTGTTGGGAGAAATTGTAAAATACAGTAATGTTATACAACTACTGCATATAAAAAGCAACAAATAT
CTTACTGTCAACAAGAGATTACCTGCTTTACTGGAGAAGAATGCCATGCGTGTGTCCTTGGATGCTGCAGGAAATGAAGGGTCTTGGTTT
TATATTCATCCGTTCTGGAAACTGAGAAGCGAGGGTGACAATATTGTTGTAGGAGATAAAGTTGTTTTGATGCCTGTGAATGCAGGGCAG
CCACTACATGCCAGCAACATAGAGCTTCTTGATAACCCAGGGTGTAAAGAGGTGAATGCTGTCAATTGCAACACCAGCTGGAAAATCACT
TTATTCATGAAATATAGTTCCTATCGAGAGGATGTATTAAAAGGAGGGGACGTTGTTAGATTATTTCATGCGGAACAAGAGAAGTTTTTG
ACTTGTGATGAATATGAGAAAAAACAGCACATTTTCCTTCGTACGACCTTGCGCCAATCAGCTACTTCTGCTACTAGTTCTAAAGCACTC
TGGGAAATAGAGGTGGTTCATCATGACCCATGCCGTGGGGGTGCAGGACAGTGGAACAGCTTGTTCAGATTTAAGCATCTTGCAACTGGA
AACTATTTAGCTGCAGAGCTTAATCCTGATTATCGAGATGCCCAAAATGAAGGAAAAAATGTGAGAGATGGAGTCCCTCCAACTTCAAAG
AAAAAACGCCAGGCAGGGGAGAAGATCATGTATACTTTGGTTTCAGTCCCGCATGGCAATGACATTGCATCCCTTTTTGAACTAGATGCC
ACAACTCTTCAGAGAGCTGACTGCCTGGTTCCAAGGAACTCATATGTTCGGTTAAGGCATTTATGCACCAACACATGGGTAACCAGTACT
AGTATCCCCATAGACACAGATGAAGAGAGGCCTGTTATGTTAAAGATTGGAACCTGCCAAACCAAAGAAGATAAAGAAGCGTTCGCAATC
GTGTCTGTTCCACTGTCTGAAGTTCGAGACTTAGACTTTGCCAATGATGCCAATAAAGTACTAGCGACCACAGTTAAAAAGCTAGAAAAC
GGCACAATAACTCAGAATGAAAGGAGGTTTGTAACCAAATTATTGGAAGATCTCATATTCTTTGTTGCTGATGTGCCTAATAATGGACAA
GAAGTTCTGGATGTGGTTATCACTAAGCCAAACCGAGAGCGTCAAAAATTGATGAGGGAACAAAACATACTGGCACAGGTATTTGGAATT
CTTAAAGCACCCTTTAAAGAGAAAGCAGGAGAAGGCTCGATGCTGAGACTTGAAGATCTGGGGGATCAAAGATATGCACCCTACAAGTAC
ATGCTGCGGCTCTGTTACCGCGTCCTGAGACACTCGCAGCAGGATTACCGGAAAAATCAGGAATATATTGCTAAGAATTTCTGTGTCATG
CAGTCCCAGATTGGCTATGATATTTTGGCAGAAGATACTATCACAGCTTTGTTGCACAACAACAGAAAACTACTAGAGAAACATATCACA
GCAAAAGAAATAGAAACATTTGTCAGTTTACTCAGGAGAAATCGGGAGCCAAGGTTTTTGGATTATTTGTCAGATCTGTGTGTGTCTAAT
ACCACTGCTATCCCTGTAACTCAAGAACTCATCTGTAAATTTATGTTGAGTCCAGGCAATGCAGACATTCTCATTCAAACTAAGGTGGTC
TCAATGCAAGCAGACAACCCCATGGAGAGCTCCATCCTTTCAGATGACATTGATGATGAAGAAGTTTGGCTCTATTGGATTGACAGCAAC
AAGGAACCTCATGGCAAAGCTATCAGGCACCTTGCTCAAGAGGCAAAAGAAGGCACCAAAGCTGACTTAGAAGTTCTTACCTATTACAGG
TACCAGCTAAACCTCTTTGCAAGGATGTGCTTGGATCGCCAGTATCTGGCCATAAACCAGATTTCTACACAGCTGTCTGTAGACCTGATC
CTGCGGTGTGTGTCGGATGAGAGCCTGCCGTTCGACCTCCGAGCGTCCTTCTGTCGCCTCATGCTCCACATGCACGTTGACCGGGATCCC
CAGGAGTCCGTGGTGCCTGTTCGCTATGCCAGGCTCTGGACAGAAATCCCCACAAAGATCACAATTCATGAATATGATTCTATAACAGAC
TCTTCCAGAAATGATATGAAGAGGAAATTTGCCCTGACAATGGAATTTGTTGAAGAATATTTGAAAGAAGTTGTAAACCAGCCCTTTCCT
TTTGGGGATAAAGAAAAAAATAAACTGACATTTGAGGTGGTCCACTTGGCTCGGAATCTTATATACTTTGGATTTTATAGTTTCAGTGAG
TTATTAAGGCTAACAAGAACACTTCTGGCTATTTTAGACATTGTACAGGCCCCCATGTCATCATACTTTGAAAGATTAAGCAAATTTCAA
GATGGAGGAAACAATGTGATGAGAACCATTCATGGGGTGGGAGAGATGATGACCCAGATGGTACTCAGTAGAGGCTCCATCTTCCCCATG
AGCGTGCCGGATGTGCCACCCAGCATCCACCCGAGCAAGCAAGGGAGCCCCACCGAGCACGAGGATGTGACTGTGATGGACACCAAGCTG
AAGATCATTGAGATTTTGCAGTTTATCCTGAGTGTCAGACTGGATTATAGGATCTCATATATGCTGTCAATATATAAGAAGGAGTTTGGA
GAGGACAATGACAATGCGGAGACATCTGCCAGTGGATCTCCAGACACTTTACTACCATCAGCTATTGTTCCTGATATAGATGAAATTGCA
GCTCAGGCAGAAACTATGTTTGCGGGAAGAAAAGAAAAAAATCCAGTTCAACTTGACGATGAAGGAGGCAGGACGTTTTTACGGGTCCTC
ATTCATCTGATCATGCACGACTACCCGCCTTTGCTGTCTGGAGCCCTGCAGCTGTTGTTTAAGCACTTCAGCCAGAGGGCAGAGGTTTTA
CAGGCATTTAAGCAGGTGCAATTACTGGTGTCTAATCAAGACGTAGATAACTACAAGCAAATCAAGGCAGATCTAGACCAGCTTCGACTG
ACAGTAGAAAAGTCTGAGCTATGGGTGGAGAAGAGCAGCAACTATGAGAATGGAGAAATAGGGGAAAGTCAAGTGAAAGGTGGTGAAGAG
CCAATTGAGGCAGAAACCACTAATACTAGCCTCTTGCAGGTGCAACTGGAATGCAGTTTACATAATAAAGTGTGTCAGCAATTAAAGGGT
TGTTATCTGGAATCTGATGATGTTTTGCGTCTACAAATGAGCATAATGGTAACAATGGAAAACTTTTCAAAAGAATTTGAAGAAAACACA
CAACATTTGTTAGATCATCTCTCTATTGTTTACGTAGCTACAGATGAATCTGAGACCTCAGATGATTCAGCAGTAAATATGTATATATTA
CATTCAGGAAACAGCCTTATATGGATACAGGATATACGCCATTTCTCACAGAGAGATGCTCTGTCTCTGCAGTTTGAACCAGTACTACTA
CCTACTTCTACAACAAACTTTACAAAAATTGCTTCTTTTACCTGCAAAGCAGCTACATCATGTGACAGTGGAATTATAGAAGATGTGAAG
AAAACAACACACACTCCAACACTAAAAGCATGCCTCTTCTCTTCTGTGGCTCAGGGGTATTTTAGAATGGACTCTTCTGCAACCCAGTTT
CACATAGAGACTCATGAGAACACATCAGGACTTTGGTCAATATGGTACCGCAACCATTTTGACCGTAGTGTTGTATTAAATGATGTGTTT
CTTTCCAAGGAGACCAAGCACATGTTAAAGATTCTGAATTTCACTGGCCCTTTATTTCTACCTCCAGGCTGTTGGAATATATTTTCTTTG
AAACTTGCTGTTAAAGACATTGCCATAAATCTATTCACCAATGTATTTTTGACTACAAACATAGGTGCCATTTTTGCAATACCTCTACAG
ATTTATTCAGCACCAACCAAGGAAGGGAGTCTGGGTTTTGAAGTGATAGCACATTGTGGCATGCATTATTTCATGGGAAAATCAAAAGCA
GGAAATCCTAATTGGAATGGGAGCCTTTCTCTGGATCAATCTACCTGGAATGTGGATTCTGAACTTGCAAATAAATTGTATGAAAGATGG
AAGAAATATAAAAATGGTGACGTCTGCAAGTTTGGCACTGATATGCAGATGATTAATTTCACAACTGGTGAATTCCAGCTCACCGAAGCT
TGCCCTTACCTGGGTACGCATTCTGAGGAATCCAGGTTTGGCATCCTCCACTTACATCTGCAGCCTTTGGAAATGAAAAGGGTTGGCGTA
GTTTTCACACCTGCTGACTATGGAAAAGTTACCTCACTCATACTAATCCGGAATAACTTGACTGTTATTGACATGATTGGCGTGGAAGGA
TTTGGAGCAAGAGAGTTATTAAAAGTGGGTGGAAGACTTCCTGGTGCAGGAGGCTCACTCCGATTTAAGGTGCCCGAGTCCACGCTGATG
GACTGCCGTAGACAACTGAAAGACAGTAAGCAAATTTTATCTATTACAAAGAACTTTAAAGTTGAGAATATTGGACCTCTTCCTATAACT
GTTTCGTCTCTGAAAATTAATGGGTATAACTGCCAAGGTTATGGATTCGAGGTGCTGGATTGTCATCAGTTTTCCCTGGACCCAAACACA
TCCCGCGATATCAGCATTGTGTTCACTCCAGACTTTACCTCCTCCTGGGTAATTCGGGACCTAAGTCTTGTAACCGCAGCGGACCTAGAA
TTTCGCTTCACTCTCAATGTGACTCTCCCTCATCACCTGTTGCCCTTGTGTGCAGACGTGGTTCCAGGACCCAGCTGGGAGGAGTCATTT
TGGAGGCTCACGGTCTTCTTTGTCAGTTTGTCCCTGTTGGGTGTGATTTTAATAGCCTTCCAACAAGCACAGTACATTCTCATGGAATTC
ATGAAAACAAGACAGAGGCAAAATGCTAGCTCCTCTTCACAGCAAAACAATGGTCCTATGGATGTAATCAGCCCCCATTCTTACAAAAGC
AATTGCAAGAACTTTCTCGATACATATGGCCCCTCTGATAAAGGCAGGGGGAAGAACTGCCTTCCAGTGAACACTCCCCAAAGCAGGATC
CAGAATGCTGCAAAGAGGAGCCCAGCCACCTATGGTCATTCTCAGAAGAAGCACAAATGCTCAGTGTATTACAGTAAACACAAAACCAGC
ACAGCTGCGGCCAGCAGCACCAGCACGACTACTGAGGAAAAACAGACTTCACCCCTGGGCAGCTCACTGCCTGCTGCTAAAGAGGACATT
TGCACTGATGCCATGCGTGAGAACTGGATCAGCCTCAGATATGCAAGTGGCATAAATGTCAACCTGCAGAAGAATTTAACCCTTCCCAAA
AACTTACTGAATAAAGAAGAAAACACACTGAAAAACACAATTGTTTTCAGTAATCCTTCTTCAGAATGTAGTATGAAGGAGGGAATACAG
ACATGTATGTTTCCTAAGGAAACTGACATTAAAACTTCAGAGAACACAGCCGAGTTCAAGGAACGGGAGCTCTGTCCACTGAAGACCTCC
AAGAAACTACCTGAAAACCATTTACCAAGAAACTCACCTCAGTACCACCAGCCAGACTTGCCAGAAATTTCCAGGAAAAATAATGGGAAT
AACCAGCAAGTACCTGTCAAGAATGAAGTAGATCATTGTGAAAATTTGAAGAAGGTGGACACAAAGCCTTCTTCAGAAAAGAAGATTCAC
AAAACATCTAGAGAAGACATGTTTTCTGAGAAACAGGACATACCTTTCGTAGAGCAAGAAGATCCTTATAGGAAGAAAAAGCTTCAGGAG
AAAAGAGAAGGAAATTTACAAAATTTAAATTGGAGTAAAAGTCGAACATGTAGAAAGAACAAGAAAAGGGGTGTTGCTCCAGTCTCAAGG
CCTCCTGAACAGAGTGATCTAAAGCTTGTGTGCAGTGACTTTGAGAGGTCTGAGCTGAGCAGTGACATCAATGTAAGAAGCTGGTGTATA
CAGGAAAGCACTAGGGAGGTTTGTAAAGCAGATGCCGAAATTGCAAGCAGTTTACCTGCTGCCCAGAGAGAGGCAGAAGGTTACTACCAG
AAGCCTGAGAAGAAATGTGTGGACAAGTTCTGCTCCGATTCCAGCTCTGACTGTGGGAGCTCCTCTGGCAGCGTGCGTGCCAGCCGGGGC
AGCTGGGGGAGCTGGAGCAGCACCAGCAGCTCCGACGGGGATAAGAAGCCCATGGTGGACGCCCAGCACTTCCTGCCGGCCGGAGACAGT
GTTTCACAAAATGATTTTCCTTCTGAAGCTCCCATCTCCTTGAATCTTTCTCATAACATCTGCAATCCCATGACCGTGAATAGTCTCCCA
CAATACGCAGAGCCTTCCTGTCCCAGCCTTCCTGCCGGGCCCACAGGTGTTGAAGAAGATAAAGGTCTTTACTCACCTGGAGACCTGTGG
CCCACTCCGCCAGTGTGTGTGACAAGCAGCTTAAACTGCACCCTGGAGAACGGCGTGCCTTGTGTGATTCAGGAGTCGGCCCCGGTTCAT
AATAGTTTCATTGATTGGAGTGCAACATGCGAAGGCCAGTTTTCCAGCGCATACTGTCCATTGGAATTGAACGATTACAATGCCTTTCCA
GAAGAAAACATGAACTATGCCAATGGCTTCCCCTGTCCTGCAGATGTTCAGACAGACTTTATTGATCACAACTCTCAGTCTACCTGGAAC
ACCCCACCCAACATGCCTGCTGCCTGGGGACATGCCAGTTTCATCAGCTCTCCGCCCTACCTCACAAGCACCCGAAGCTTGTCTCCAATG
TCTGGACTTTTTGGTTCCATCTGGGCCCCGCAAAGCGATGTGTATGAAAATTGCTGCCCCATCAACCCCACCACGGAACATTCGACCCAC
ATGGAAAACCAAGCGGTCGTGTGCAAGGAATACTACCCGGGGTTCAACCCGTTTCGCGCCTATATGAACCTGGACATATGGACTACCACA
GCGAATAGGAATGCAAATTTCCCACTGTCTAGAGACTCGAGTTACTGTGGGAATGTGTGAAAATAATTGGATTTTTAAACAATGTGAATA
AAGAGGCTTGTGTTTTGATTACTAGTGTAAACTGGTTATTGAGATAGATTATGACATTGGTGGATATTTTGGCACTTTTATATGAAAATA

>In-frame_ENST00000381340_ENST00000440693_TCGA-L5-A4ON_ITPR2_chr12_26774055_-_KIAA0922_chr4_154501977_length(amino acids)=2460AA_start in transcript=417_stop in transcript=7799
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLK
KLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQ
SATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANK
VLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRF
LDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTK
ITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRIS
YMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEAETTNTSLLQVQLECS
LHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRD
ALSLQFEPVLLPTSTTNFTKIASFTCKAATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNH
FDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHC
GMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLH
LQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNF
KVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCAD
VVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKN
CLPVNTPQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGIN
VNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPD
LPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRK
NKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCG
SSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEE
DKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTD
FIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFR

--------------------------------------------------------------
>In-frame_ENST00000381340_ENST00000409663_TCGA-L5-A4ON_ITPR2_chr12_26774055_-_KIAA0922_chr4_154501977_length(transcript)=8184nt_BP=3879nt
CTTCCAGCTCCCGCCGGGCGGCTGTGACGGCCGCAGCGGGTCGCAGAGCAGGGAGTGGACACGGAGTGGGGAGCGGAGAGGGAAGGAGGA
GGAGGAGGAGCAAAGGTGTTGGAGAGAAAACTTCAGAAAGGAACAGGAAACCTGCCGGGGAGGCGGCGGCGGCTGCGGCTTCTCTGGGCG
CCTGGGCTGCGCTCTTCGCGGGGTGTCCGCAGCTGCGGCTTGGCCCCGGTCTGGCTTCCCCGGCGCGCACGCACGGCTGAGCCGCGACGC
TCAGTGGCTCGGGCCGTGCCCTCCGCCGCGGCTCTTGGCCGCTGTAGTCCCGCGATCCGATCCGCTTCTGCCGCGGCGGCTCCCTGGAGA
GAGGGCGGCGAGGGCGCAGGGAAGAAGAGGGACGTCCACTGTGGAACATGAAGCAGCATGACTGAGAAAATGTCCAGCTTCCTCTACATA
GGGGACATCGTGTCCCTGTACGCGGAGGGCTCGGTCAACGGCTTCATCAGCACCTTGGGGTTAGTGGATGACAGATGTGTGGTGCACCCA
GAGGCCGGGGACCTTGCCAACCCTCCCAAGAAGTTCAGAGACTGCCTTTTCAAGGTGTGCCCTATGAACAGATATTCTGCCCAGAAGCAA
TATTGGAAAGCAAAGCAAGCCAAACAAGGGAACCACACCGAGGCAGCCTTGCTGAAGAAACTACAGCACGCTGCAGAACTGGAACAAAAA
CAAAATGAATCGGAGAATAAGAAACTGTTGGGAGAAATTGTAAAATACAGTAATGTTATACAACTACTGCATATAAAAAGCAACAAATAT
CTTACTGTCAACAAGAGATTACCTGCTTTACTGGAGAAGAATGCCATGCGTGTGTCCTTGGATGCTGCAGGAAATGAAGGGTCTTGGTTT
TATATTCATCCGTTCTGGAAACTGAGAAGCGAGGGTGACAATATTGTTGTAGGAGATAAAGTTGTTTTGATGCCTGTGAATGCAGGGCAG
CCACTACATGCCAGCAACATAGAGCTTCTTGATAACCCAGGGTGTAAAGAGGTGAATGCTGTCAATTGCAACACCAGCTGGAAAATCACT
TTATTCATGAAATATAGTTCCTATCGAGAGGATGTATTAAAAGGAGGGGACGTTGTTAGATTATTTCATGCGGAACAAGAGAAGTTTTTG
ACTTGTGATGAATATGAGAAAAAACAGCACATTTTCCTTCGTACGACCTTGCGCCAATCAGCTACTTCTGCTACTAGTTCTAAAGCACTC
TGGGAAATAGAGGTGGTTCATCATGACCCATGCCGTGGGGGTGCAGGACAGTGGAACAGCTTGTTCAGATTTAAGCATCTTGCAACTGGA
AACTATTTAGCTGCAGAGCTTAATCCTGATTATCGAGATGCCCAAAATGAAGGAAAAAATGTGAGAGATGGAGTCCCTCCAACTTCAAAG
AAAAAACGCCAGGCAGGGGAGAAGATCATGTATACTTTGGTTTCAGTCCCGCATGGCAATGACATTGCATCCCTTTTTGAACTAGATGCC
ACAACTCTTCAGAGAGCTGACTGCCTGGTTCCAAGGAACTCATATGTTCGGTTAAGGCATTTATGCACCAACACATGGGTAACCAGTACT
AGTATCCCCATAGACACAGATGAAGAGAGGCCTGTTATGTTAAAGATTGGAACCTGCCAAACCAAAGAAGATAAAGAAGCGTTCGCAATC
GTGTCTGTTCCACTGTCTGAAGTTCGAGACTTAGACTTTGCCAATGATGCCAATAAAGTACTAGCGACCACAGTTAAAAAGCTAGAAAAC
GGCACAATAACTCAGAATGAAAGGAGGTTTGTAACCAAATTATTGGAAGATCTCATATTCTTTGTTGCTGATGTGCCTAATAATGGACAA
GAAGTTCTGGATGTGGTTATCACTAAGCCAAACCGAGAGCGTCAAAAATTGATGAGGGAACAAAACATACTGGCACAGGTATTTGGAATT
CTTAAAGCACCCTTTAAAGAGAAAGCAGGAGAAGGCTCGATGCTGAGACTTGAAGATCTGGGGGATCAAAGATATGCACCCTACAAGTAC
ATGCTGCGGCTCTGTTACCGCGTCCTGAGACACTCGCAGCAGGATTACCGGAAAAATCAGGAATATATTGCTAAGAATTTCTGTGTCATG
CAGTCCCAGATTGGCTATGATATTTTGGCAGAAGATACTATCACAGCTTTGTTGCACAACAACAGAAAACTACTAGAGAAACATATCACA
GCAAAAGAAATAGAAACATTTGTCAGTTTACTCAGGAGAAATCGGGAGCCAAGGTTTTTGGATTATTTGTCAGATCTGTGTGTGTCTAAT
ACCACTGCTATCCCTGTAACTCAAGAACTCATCTGTAAATTTATGTTGAGTCCAGGCAATGCAGACATTCTCATTCAAACTAAGGTGGTC
TCAATGCAAGCAGACAACCCCATGGAGAGCTCCATCCTTTCAGATGACATTGATGATGAAGAAGTTTGGCTCTATTGGATTGACAGCAAC
AAGGAACCTCATGGCAAAGCTATCAGGCACCTTGCTCAAGAGGCAAAAGAAGGCACCAAAGCTGACTTAGAAGTTCTTACCTATTACAGG
TACCAGCTAAACCTCTTTGCAAGGATGTGCTTGGATCGCCAGTATCTGGCCATAAACCAGATTTCTACACAGCTGTCTGTAGACCTGATC
CTGCGGTGTGTGTCGGATGAGAGCCTGCCGTTCGACCTCCGAGCGTCCTTCTGTCGCCTCATGCTCCACATGCACGTTGACCGGGATCCC
CAGGAGTCCGTGGTGCCTGTTCGCTATGCCAGGCTCTGGACAGAAATCCCCACAAAGATCACAATTCATGAATATGATTCTATAACAGAC
TCTTCCAGAAATGATATGAAGAGGAAATTTGCCCTGACAATGGAATTTGTTGAAGAATATTTGAAAGAAGTTGTAAACCAGCCCTTTCCT
TTTGGGGATAAAGAAAAAAATAAACTGACATTTGAGGTGGTCCACTTGGCTCGGAATCTTATATACTTTGGATTTTATAGTTTCAGTGAG
TTATTAAGGCTAACAAGAACACTTCTGGCTATTTTAGACATTGTACAGGCCCCCATGTCATCATACTTTGAAAGATTAAGCAAATTTCAA
GATGGAGGAAACAATGTGATGAGAACCATTCATGGGGTGGGAGAGATGATGACCCAGATGGTACTCAGTAGAGGCTCCATCTTCCCCATG
AGCGTGCCGGATGTGCCACCCAGCATCCACCCGAGCAAGCAAGGGAGCCCCACCGAGCACGAGGATGTGACTGTGATGGACACCAAGCTG
AAGATCATTGAGATTTTGCAGTTTATCCTGAGTGTCAGACTGGATTATAGGATCTCATATATGCTGTCAATATATAAGAAGGAGTTTGGA
GAGGACAATGACAATGCGGAGACATCTGCCAGTGGATCTCCAGACACTTTACTACCATCAGCTATTGTTCCTGATATAGATGAAATTGCA
GCTCAGGCAGAAACTATGTTTGCGGGAAGAAAAGAAAAAAATCCAGTTCAACTTGACGATGAAGGAGGCAGGACGTTTTTACGGGTCCTC
ATTCATCTGATCATGCACGACTACCCGCCTTTGCTGTCTGGAGCCCTGCAGCTGTTGTTTAAGCACTTCAGCCAGAGGGCAGAGGTTTTA
CAGGCATTTAAGCAGGTGCAATTACTGGTGTCTAATCAAGACGTAGATAACTACAAGCAAATCAAGGCAGATCTAGACCAGCTTCGACTG
ACAGTAGAAAAGTCTGAGCTATGGGTGGAGAAGAGCAGCAACTATGAGAATGGAGAAATAGGGGAAAGTCAAGTGAAAGGTGGTGAAGAG
CCAATTGAGGCAGAAACCACTAATACTAGCCTCTTGCAGGTGCAACTGGAATGCAGTTTACATAATAAAGTGTGTCAGCAATTAAAGGGT
TGTTATCTGGAATCTGATGATGTTTTGCGTCTACAAATGAGCATAATGGTAACAATGGAAAACTTTTCAAAAGAATTTGAAGAAAACACA
CAACATTTGTTAGATCATCTCTCTATTGTTTACGTAGCTACAGATGAATCTGAGACCTCAGATGATTCAGCAGTAAATATGTATATATTA
CATTCAGGAAACAGCCTTATATGGATACAGGATATACGCCATTTCTCACAGAGAGATGCTCTGTCTCTGCAGTTTGAACCAGTACTACTA
CCTACTTCTACAACAAACTTTACAAAAATTGCTTCTTTTACCTGCAAAGCTACATCATGTGACAGTGGAATTATAGAAGATGTGAAGAAA
ACAACACACACTCCAACACTAAAAGCATGCCTCTTCTCTTCTGTGGCTCAGGGGTATTTTAGAATGGACTCTTCTGCAACCCAGTTTCAC
ATAGAGACTCATGAGAACACATCAGGACTTTGGTCAATATGGTACCGCAACCATTTTGACCGTAGTGTTGTATTAAATGATGTGTTTCTT
TCCAAGGAGACCAAGCACATGTTAAAGATTCTGAATTTCACTGGCCCTTTATTTCTACCTCCAGGCTGTTGGAATATATTTTCTTTGAAA
CTTGCTGTTAAAGACATTGCCATAAATCTATTCACCAATGTATTTTTGACTACAAACATAGGTGCCATTTTTGCAATACCTCTACAGATT
TATTCAGCACCAACCAAGGAAGGGAGTCTGGGTTTTGAAGTGATAGCACATTGTGGCATGCATTATTTCATGGGAAAATCAAAAGCAGGA
AATCCTAATTGGAATGGGAGCCTTTCTCTGGATCAATCTACCTGGAATGTGGATTCTGAACTTGCAAATAAATTGTATGAAAGATGGAAG
AAATATAAAAATGGTGACGTCTGCAAGAGGAATGTTTTGGGAACAACTCGATTTGCTCACTTGAAGAAATCCAAGGAGTCAGAGTCCTTT
GTTTTCTTTTTGCCTCGTTTGATCGCAGAGCCTGGCCTCATGTTAAACTTCAGCGCAACTGCCCTTAGGAGCAGGATGATCAAGTACTTT
GTGGTGCAGAACCCGTCCTCTTGGCCGGTCTCCTTGCAGCTCCTGCCTCTCTCCTTGTACCCTAAACCCGAAGCCCTAGTGCACCTGCTC
CACAGATGGTTTGGCACTGATATGCAGATGATTAATTTCACAACTGGTGAATTCCAGCTCACCGAAGCTTGCCCTTACCTGGGTACGCAT
TCTGAGGAATCCAGGTTTGGCATCCTCCACTTACATCTGCAGCCTTTGGAAATGAAAAGGGTTGGCGTAGTTTTCACACCTGCTGACTAT
GGAAAAGTTACCTCACTCATACTAATCCGGAATAACTTGACTGTTATTGACATGATTGGCGTGGAAGGATTTGGAGCAAGAGAGTTATTA
AAAGTGGGTGGAAGACTTCCTGGTGCAGGAGGCTCACTCCGATTTAAGGTGCCCGAGTCCACGCTGATGGACTGCCGTAGACAACTGAAA
GACAGTAAGCAAATTTTATCTATTACAAAGAACTTTAAAGTTGAGAATATTGGACCTCTTCCTATAACTGTTTCGTCTCTGAAAATTAAT
GGGTATAACTGCCAAGGTTATGGATTCGAGGTGCTGGATTGTCATCAGTTTTCCCTGGACCCAAACACATCCCGCGATATCAGCATTGTG
TTCACTCCAGACTTTACCTCCTCCTGGGTAATTCGGGACCTAAGTCTTGTAACCGCAGCGGACCTAGAATTTCGCTTCACTCTCAATGTG
ACTCTCCCTCATCACCTGTTGCCCTTGTGTGCAGACGTGGTTCCAGGACCCAGCTGGGAGGAGTCATTTTGGAGGCTCACGGTCTTCTTT
GTCAGTTTGTCCCTGTTGGGTGTGATTTTAATAGCCTTCCAACAAGCACAGTACATTCTCATGGAATTCATGAAAACAAGACAGAGGCAA
AATGCTAGCTCCTCTTCACAGCAAAACAATGGTCCTATGGATGTAATCAGCCCCCATTCTTACAAAAGCAATTGCAAGAACTTTCTCGAT
ACATATGGCCCCTCTGATAAAGGCAGGGGGAAGAACTGCCTTCCAGTGAACACTCCCCAAAGCAGGATCCAGAATGCTGCAAAGAGGAGC
CCAGCCACCTATGGTCATTCTCAGAAGAAGCACAAATGCTCAGTGTATTACAGTAAACACAAAACCAGCACAGCTGCGGCCAGCAGCACC
AGCACGACTACTGAGGAAAAACAGACTTCACCCCTGGGCAGCTCACTGCCTGCTGCTAAAGAGGACATTTGCACTGATGCCATGCGTGAG
AACTGGATCAGCCTCAGATATGCAAGTGGCATAAATGTCAACCTGCAGAAGAATTTAACCCTTCCCAAAAACTTACTGAATAAAGAAGAA
AACACACTGAAAAACACAATTGTTTTCAGTAATCCTTCTTCAGAATGTAGTATGAAGGAGGGAATACAGACATGTATGTTTCCTAAGGAA
ACTGACATTAAAACTTCAGAGAACACAGCCGAGTTCAAGGAACGGGAGCTCTGTCCACTGAAGACCTCCAAGAAACTACCTGAAAACCAT
TTACCAAGAAACTCACCTCAGTACCACCAGCCAGACTTGCCAGAAATTTCCAGGAAAAATAATGGGAATAACCAGCAAGTACCTGTCAAG
AATGAAGTAGATCATTGTGAAAATTTGAAGAAGGTGGACACAAAGCCTTCTTCAGAAAAGAAGATTCACAAAACATCTAGAGAAGACATG
TTTTCTGAGAAACAGGACATACCTTTCGTAGAGCAAGAAGATCCTTATAGGAAGAAAAAGCTTCAGGAGAAAAGAGAAGGAAATTTACAA
AATTTAAATTGGAGTAAAAGTCGAACATGTAGAAAGAACAAGAAAAGGGGTGTTGCTCCAGTCTCAAGGCCTCCTGAACAGAGTGATCTA
AAGCTTGTGTGCAGTGACTTTGAGAGGTCTGAGCTGAGCAGTGACATCAATGTAAGAAGCTGGTGTATACAGGAAAGCACTAGGGAGGTT
TGTAAAGCAGATGCCGAAATTGCAAGCAGTTTACCTGCTGCCCAGAGAGAGGCAGAAGGTTACTACCAGAAGCCTGAGAAGAAATGTGTG
GACAAGTTCTGCTCCGATTCCAGCTCTGACTGTGGGAGCTCCTCTGGCAGCGTGCGTGCCAGCCGGGGCAGCTGGGGGAGCTGGAGCAGC
ACCAGCAGCTCCGACGGGGATAAGAAGCCCATGGTGGACGCCCAGCACTTCCTGCCGGCCGGAGACAGTGTTTCACAAAATGATTTTCCT
TCTGAAGCTCCCATCTCCTTGAATCTTTCTCATAACATCTGCAATCCCATGACCGTGAATAGTCTCCCACAATACGCAGAGCCTTCCTGT
CCCAGCCTTCCTGCCGGGCCCACAGGTGTTGAAGAAGATAAAGGTCTTTACTCACCTGGAGACCTGTGGCCCACTCCGCCAGTGTGTGTG
ACAAGCAGCTTAAACTGCACCCTGGAGAACGGCGTGCCTTGTGTGATTCAGGAGTCGGCCCCGGTTCATAATAGTTTCATTGATTGGAGT
GCAACATGCGAAGGCCAGTTTTCCAGCGCATACTGTCCATTGGAATTGAACGATTACAATGCCTTTCCAGAAGAAAACATGAACTATGCC
AATGGCTTCCCCTGTCCTGCAGATGTTCAGACAGACTTTATTGATCACAACTCTCAGTCTACCTGGAACACCCCACCCAACATGCCTGCT
GCCTGGGGACATGCCAGTTTCATCAGCTCTCCGCCCTACCTCACAAGCACCCGAAGCTTGTCTCCAATGTCTGGACTTTTTGGTTCCATC
TGGGCCCCGCAAAGCGATGTGTATGAAAATTGCTGCCCCATCAACCCCACCACGGAACATTCGACCCACATGGAAAACCAAGCGGTCGTG
TGCAAGGAATACTACCCGGGGTTCAACCCGTTTCGCGCCTATATGAACCTGGACATATGGACTACCACAGCGAATAGGAATGCAAATTTC
CCACTGTCTAGAGACTCGAGTTACTGTGGGAATGTGTGAAAATAATTGGATTTTTAAACAATGTGAATAAAGAGGCTTGTGTTTTGATTA

>In-frame_ENST00000381340_ENST00000409663_TCGA-L5-A4ON_ITPR2_chr12_26774055_-_KIAA0922_chr4_154501977_length(amino acids)=2543AA_start in transcript=417_stop in transcript=8048
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLK
KLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQ
SATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANK
VLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRF
LDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTK
ITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRIS
YMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEAETTNTSLLQVQLECS
LHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRD
ALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHF
DRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCG
MHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSA
TALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMK
RVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGP
LPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSW
EESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTP
QSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNL
TLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRK
NNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVA
PVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVR
ASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYSP
GDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQ
STWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDI

--------------------------------------------------------------
>In-frame_ENST00000381340_ENST00000409959_TCGA-L5-A4ON_ITPR2_chr12_26774055_-_KIAA0922_chr4_154501977_length(transcript)=8187nt_BP=3879nt
CTTCCAGCTCCCGCCGGGCGGCTGTGACGGCCGCAGCGGGTCGCAGAGCAGGGAGTGGACACGGAGTGGGGAGCGGAGAGGGAAGGAGGA
GGAGGAGGAGCAAAGGTGTTGGAGAGAAAACTTCAGAAAGGAACAGGAAACCTGCCGGGGAGGCGGCGGCGGCTGCGGCTTCTCTGGGCG
CCTGGGCTGCGCTCTTCGCGGGGTGTCCGCAGCTGCGGCTTGGCCCCGGTCTGGCTTCCCCGGCGCGCACGCACGGCTGAGCCGCGACGC
TCAGTGGCTCGGGCCGTGCCCTCCGCCGCGGCTCTTGGCCGCTGTAGTCCCGCGATCCGATCCGCTTCTGCCGCGGCGGCTCCCTGGAGA
GAGGGCGGCGAGGGCGCAGGGAAGAAGAGGGACGTCCACTGTGGAACATGAAGCAGCATGACTGAGAAAATGTCCAGCTTCCTCTACATA
GGGGACATCGTGTCCCTGTACGCGGAGGGCTCGGTCAACGGCTTCATCAGCACCTTGGGGTTAGTGGATGACAGATGTGTGGTGCACCCA
GAGGCCGGGGACCTTGCCAACCCTCCCAAGAAGTTCAGAGACTGCCTTTTCAAGGTGTGCCCTATGAACAGATATTCTGCCCAGAAGCAA
TATTGGAAAGCAAAGCAAGCCAAACAAGGGAACCACACCGAGGCAGCCTTGCTGAAGAAACTACAGCACGCTGCAGAACTGGAACAAAAA
CAAAATGAATCGGAGAATAAGAAACTGTTGGGAGAAATTGTAAAATACAGTAATGTTATACAACTACTGCATATAAAAAGCAACAAATAT
CTTACTGTCAACAAGAGATTACCTGCTTTACTGGAGAAGAATGCCATGCGTGTGTCCTTGGATGCTGCAGGAAATGAAGGGTCTTGGTTT
TATATTCATCCGTTCTGGAAACTGAGAAGCGAGGGTGACAATATTGTTGTAGGAGATAAAGTTGTTTTGATGCCTGTGAATGCAGGGCAG
CCACTACATGCCAGCAACATAGAGCTTCTTGATAACCCAGGGTGTAAAGAGGTGAATGCTGTCAATTGCAACACCAGCTGGAAAATCACT
TTATTCATGAAATATAGTTCCTATCGAGAGGATGTATTAAAAGGAGGGGACGTTGTTAGATTATTTCATGCGGAACAAGAGAAGTTTTTG
ACTTGTGATGAATATGAGAAAAAACAGCACATTTTCCTTCGTACGACCTTGCGCCAATCAGCTACTTCTGCTACTAGTTCTAAAGCACTC
TGGGAAATAGAGGTGGTTCATCATGACCCATGCCGTGGGGGTGCAGGACAGTGGAACAGCTTGTTCAGATTTAAGCATCTTGCAACTGGA
AACTATTTAGCTGCAGAGCTTAATCCTGATTATCGAGATGCCCAAAATGAAGGAAAAAATGTGAGAGATGGAGTCCCTCCAACTTCAAAG
AAAAAACGCCAGGCAGGGGAGAAGATCATGTATACTTTGGTTTCAGTCCCGCATGGCAATGACATTGCATCCCTTTTTGAACTAGATGCC
ACAACTCTTCAGAGAGCTGACTGCCTGGTTCCAAGGAACTCATATGTTCGGTTAAGGCATTTATGCACCAACACATGGGTAACCAGTACT
AGTATCCCCATAGACACAGATGAAGAGAGGCCTGTTATGTTAAAGATTGGAACCTGCCAAACCAAAGAAGATAAAGAAGCGTTCGCAATC
GTGTCTGTTCCACTGTCTGAAGTTCGAGACTTAGACTTTGCCAATGATGCCAATAAAGTACTAGCGACCACAGTTAAAAAGCTAGAAAAC
GGCACAATAACTCAGAATGAAAGGAGGTTTGTAACCAAATTATTGGAAGATCTCATATTCTTTGTTGCTGATGTGCCTAATAATGGACAA
GAAGTTCTGGATGTGGTTATCACTAAGCCAAACCGAGAGCGTCAAAAATTGATGAGGGAACAAAACATACTGGCACAGGTATTTGGAATT
CTTAAAGCACCCTTTAAAGAGAAAGCAGGAGAAGGCTCGATGCTGAGACTTGAAGATCTGGGGGATCAAAGATATGCACCCTACAAGTAC
ATGCTGCGGCTCTGTTACCGCGTCCTGAGACACTCGCAGCAGGATTACCGGAAAAATCAGGAATATATTGCTAAGAATTTCTGTGTCATG
CAGTCCCAGATTGGCTATGATATTTTGGCAGAAGATACTATCACAGCTTTGTTGCACAACAACAGAAAACTACTAGAGAAACATATCACA
GCAAAAGAAATAGAAACATTTGTCAGTTTACTCAGGAGAAATCGGGAGCCAAGGTTTTTGGATTATTTGTCAGATCTGTGTGTGTCTAAT
ACCACTGCTATCCCTGTAACTCAAGAACTCATCTGTAAATTTATGTTGAGTCCAGGCAATGCAGACATTCTCATTCAAACTAAGGTGGTC
TCAATGCAAGCAGACAACCCCATGGAGAGCTCCATCCTTTCAGATGACATTGATGATGAAGAAGTTTGGCTCTATTGGATTGACAGCAAC
AAGGAACCTCATGGCAAAGCTATCAGGCACCTTGCTCAAGAGGCAAAAGAAGGCACCAAAGCTGACTTAGAAGTTCTTACCTATTACAGG
TACCAGCTAAACCTCTTTGCAAGGATGTGCTTGGATCGCCAGTATCTGGCCATAAACCAGATTTCTACACAGCTGTCTGTAGACCTGATC
CTGCGGTGTGTGTCGGATGAGAGCCTGCCGTTCGACCTCCGAGCGTCCTTCTGTCGCCTCATGCTCCACATGCACGTTGACCGGGATCCC
CAGGAGTCCGTGGTGCCTGTTCGCTATGCCAGGCTCTGGACAGAAATCCCCACAAAGATCACAATTCATGAATATGATTCTATAACAGAC
TCTTCCAGAAATGATATGAAGAGGAAATTTGCCCTGACAATGGAATTTGTTGAAGAATATTTGAAAGAAGTTGTAAACCAGCCCTTTCCT
TTTGGGGATAAAGAAAAAAATAAACTGACATTTGAGGTGGTCCACTTGGCTCGGAATCTTATATACTTTGGATTTTATAGTTTCAGTGAG
TTATTAAGGCTAACAAGAACACTTCTGGCTATTTTAGACATTGTACAGGCCCCCATGTCATCATACTTTGAAAGATTAAGCAAATTTCAA
GATGGAGGAAACAATGTGATGAGAACCATTCATGGGGTGGGAGAGATGATGACCCAGATGGTACTCAGTAGAGGCTCCATCTTCCCCATG
AGCGTGCCGGATGTGCCACCCAGCATCCACCCGAGCAAGCAAGGGAGCCCCACCGAGCACGAGGATGTGACTGTGATGGACACCAAGCTG
AAGATCATTGAGATTTTGCAGTTTATCCTGAGTGTCAGACTGGATTATAGGATCTCATATATGCTGTCAATATATAAGAAGGAGTTTGGA
GAGGACAATGACAATGCGGAGACATCTGCCAGTGGATCTCCAGACACTTTACTACCATCAGCTATTGTTCCTGATATAGATGAAATTGCA
GCTCAGGCAGAAACTATGTTTGCGGGAAGAAAAGAAAAAAATCCAGTTCAACTTGACGATGAAGGAGGCAGGACGTTTTTACGGGTCCTC
ATTCATCTGATCATGCACGACTACCCGCCTTTGCTGTCTGGAGCCCTGCAGCTGTTGTTTAAGCACTTCAGCCAGAGGGCAGAGGTTTTA
CAGGCATTTAAGCAGGTGCAATTACTGGTGTCTAATCAAGACGTAGATAACTACAAGCAAATCAAGGCAGATCTAGACCAGCTTCGACTG
ACAGTAGAAAAGTCTGAGCTATGGGTGGAGAAGAGCAGCAACTATGAGAATGGAGAAATAGGGGAAAGTCAAGTGAAAGGTGGTGAAGAG
CCAATTGAGGCAGAAACCACTAATACTAGCCTCTTGCAGGTGCAACTGGAATGCAGTTTACATAATAAAGTGTGTCAGCAATTAAAGGGT
TGTTATCTGGAATCTGATGATGTTTTGCGTCTACAAATGAGCATAATGGTAACAATGGAAAACTTTTCAAAAGAATTTGAAGAAAACACA
CAACATTTGTTAGATCATCTCTCTATTGTTTACGTAGCTACAGATGAATCTGAGACCTCAGATGATTCAGCAGTAAATATGTATATATTA
CATTCAGGAAACAGCCTTATATGGATACAGGATATACGCCATTTCTCACAGAGAGATGCTCTGTCTCTGCAGTTTGAACCAGTACTACTA
CCTACTTCTACAACAAACTTTACAAAAATTGCTTCTTTTACCTGCAAAGCAGCTACATCATGTGACAGTGGAATTATAGAAGATGTGAAG
AAAACAACACACACTCCAACACTAAAAGCATGCCTCTTCTCTTCTGTGGCTCAGGGGTATTTTAGAATGGACTCTTCTGCAACCCAGTTT
CACATAGAGACTCATGAGAACACATCAGGACTTTGGTCAATATGGTACCGCAACCATTTTGACCGTAGTGTTGTATTAAATGATGTGTTT
CTTTCCAAGGAGACCAAGCACATGTTAAAGATTCTGAATTTCACTGGCCCTTTATTTCTACCTCCAGGCTGTTGGAATATATTTTCTTTG
AAACTTGCTGTTAAAGACATTGCCATAAATCTATTCACCAATGTATTTTTGACTACAAACATAGGTGCCATTTTTGCAATACCTCTACAG
ATTTATTCAGCACCAACCAAGGAAGGGAGTCTGGGTTTTGAAGTGATAGCACATTGTGGCATGCATTATTTCATGGGAAAATCAAAAGCA
GGAAATCCTAATTGGAATGGGAGCCTTTCTCTGGATCAATCTACCTGGAATGTGGATTCTGAACTTGCAAATAAATTGTATGAAAGATGG
AAGAAATATAAAAATGGTGACGTCTGCAAGAGGAATGTTTTGGGAACAACTCGATTTGCTCACTTGAAGAAATCCAAGGAGTCAGAGTCC
TTTGTTTTCTTTTTGCCTCGTTTGATCGCAGAGCCTGGCCTCATGTTAAACTTCAGCGCAACTGCCCTTAGGAGCAGGATGATCAAGTAC
TTTGTGGTGCAGAACCCGTCCTCTTGGCCGGTCTCCTTGCAGCTCCTGCCTCTCTCCTTGTACCCTAAACCCGAAGCCCTAGTGCACCTG
CTCCACAGATGGTTTGGCACTGATATGCAGATGATTAATTTCACAACTGGTGAATTCCAGCTCACCGAAGCTTGCCCTTACCTGGGTACG
CATTCTGAGGAATCCAGGTTTGGCATCCTCCACTTACATCTGCAGCCTTTGGAAATGAAAAGGGTTGGCGTAGTTTTCACACCTGCTGAC
TATGGAAAAGTTACCTCACTCATACTAATCCGGAATAACTTGACTGTTATTGACATGATTGGCGTGGAAGGATTTGGAGCAAGAGAGTTA
TTAAAAGTGGGTGGAAGACTTCCTGGTGCAGGAGGCTCACTCCGATTTAAGGTGCCCGAGTCCACGCTGATGGACTGCCGTAGACAACTG
AAAGACAGTAAGCAAATTTTATCTATTACAAAGAACTTTAAAGTTGAGAATATTGGACCTCTTCCTATAACTGTTTCGTCTCTGAAAATT
AATGGGTATAACTGCCAAGGTTATGGATTCGAGGTGCTGGATTGTCATCAGTTTTCCCTGGACCCAAACACATCCCGCGATATCAGCATT
GTGTTCACTCCAGACTTTACCTCCTCCTGGGTAATTCGGGACCTAAGTCTTGTAACCGCAGCGGACCTAGAATTTCGCTTCACTCTCAAT
GTGACTCTCCCTCATCACCTGTTGCCCTTGTGTGCAGACGTGGTTCCAGGACCCAGCTGGGAGGAGTCATTTTGGAGGCTCACGGTCTTC
TTTGTCAGTTTGTCCCTGTTGGGTGTGATTTTAATAGCCTTCCAACAAGCACAGTACATTCTCATGGAATTCATGAAAACAAGACAGAGG
CAAAATGCTAGCTCCTCTTCACAGCAAAACAATGGTCCTATGGATGTAATCAGCCCCCATTCTTACAAAAGCAATTGCAAGAACTTTCTC
GATACATATGGCCCCTCTGATAAAGGCAGGGGGAAGAACTGCCTTCCAGTGAACACTCCCCAAAGCAGGATCCAGAATGCTGCAAAGAGG
AGCCCAGCCACCTATGGTCATTCTCAGAAGAAGCACAAATGCTCAGTGTATTACAGTAAACACAAAACCAGCACAGCTGCGGCCAGCAGC
ACCAGCACGACTACTGAGGAAAAACAGACTTCACCCCTGGGCAGCTCACTGCCTGCTGCTAAAGAGGACATTTGCACTGATGCCATGCGT
GAGAACTGGATCAGCCTCAGATATGCAAGTGGCATAAATGTCAACCTGCAGAAGAATTTAACCCTTCCCAAAAACTTACTGAATAAAGAA
GAAAACACACTGAAAAACACAATTGTTTTCAGTAATCCTTCTTCAGAATGTAGTATGAAGGAGGGAATACAGACATGTATGTTTCCTAAG
GAAACTGACATTAAAACTTCAGAGAACACAGCCGAGTTCAAGGAACGGGAGCTCTGTCCACTGAAGACCTCCAAGAAACTACCTGAAAAC
CATTTACCAAGAAACTCACCTCAGTACCACCAGCCAGACTTGCCAGAAATTTCCAGGAAAAATAATGGGAATAACCAGCAAGTACCTGTC
AAGAATGAAGTAGATCATTGTGAAAATTTGAAGAAGGTGGACACAAAGCCTTCTTCAGAAAAGAAGATTCACAAAACATCTAGAGAAGAC
ATGTTTTCTGAGAAACAGGACATACCTTTCGTAGAGCAAGAAGATCCTTATAGGAAGAAAAAGCTTCAGGAGAAAAGAGAAGGAAATTTA
CAAAATTTAAATTGGAGTAAAAGTCGAACATGTAGAAAGAACAAGAAAAGGGGTGTTGCTCCAGTCTCAAGGCCTCCTGAACAGAGTGAT
CTAAAGCTTGTGTGCAGTGACTTTGAGAGGTCTGAGCTGAGCAGTGACATCAATGTAAGAAGCTGGTGTATACAGGAAAGCACTAGGGAG
GTTTGTAAAGCAGATGCCGAAATTGCAAGCAGTTTACCTGCTGCCCAGAGAGAGGCAGAAGGTTACTACCAGAAGCCTGAGAAGAAATGT
GTGGACAAGTTCTGCTCCGATTCCAGCTCTGACTGTGGGAGCTCCTCTGGCAGCGTGCGTGCCAGCCGGGGCAGCTGGGGGAGCTGGAGC
AGCACCAGCAGCTCCGACGGGGATAAGAAGCCCATGGTGGACGCCCAGCACTTCCTGCCGGCCGGAGACAGTGTTTCACAAAATGATTTT
CCTTCTGAAGCTCCCATCTCCTTGAATCTTTCTCATAACATCTGCAATCCCATGACCGTGAATAGTCTCCCACAATACGCAGAGCCTTCC
TGTCCCAGCCTTCCTGCCGGGCCCACAGGTGTTGAAGAAGATAAAGGTCTTTACTCACCTGGAGACCTGTGGCCCACTCCGCCAGTGTGT
GTGACAAGCAGCTTAAACTGCACCCTGGAGAACGGCGTGCCTTGTGTGATTCAGGAGTCGGCCCCGGTTCATAATAGTTTCATTGATTGG
AGTGCAACATGCGAAGGCCAGTTTTCCAGCGCATACTGTCCATTGGAATTGAACGATTACAATGCCTTTCCAGAAGAAAACATGAACTAT
GCCAATGGCTTCCCCTGTCCTGCAGATGTTCAGACAGACTTTATTGATCACAACTCTCAGTCTACCTGGAACACCCCACCCAACATGCCT
GCTGCCTGGGGACATGCCAGTTTCATCAGCTCTCCGCCCTACCTCACAAGCACCCGAAGCTTGTCTCCAATGTCTGGACTTTTTGGTTCC
ATCTGGGCCCCGCAAAGCGATGTGTATGAAAATTGCTGCCCCATCAACCCCACCACGGAACATTCGACCCACATGGAAAACCAAGCGGTC
GTGTGCAAGGAATACTACCCGGGGTTCAACCCGTTTCGCGCCTATATGAACCTGGACATATGGACTACCACAGCGAATAGGAATGCAAAT
TTCCCACTGTCTAGAGACTCGAGTTACTGTGGGAATGTGTGAAAATAATTGGATTTTTAAACAATGTGAATAAAGAGGCTTGTGTTTTGA

>In-frame_ENST00000381340_ENST00000409959_TCGA-L5-A4ON_ITPR2_chr12_26774055_-_KIAA0922_chr4_154501977_length(amino acids)=2544AA_start in transcript=417_stop in transcript=8051
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLK
KLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQ
SATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANK
VLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRF
LDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTK
ITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRIS
YMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEAETTNTSLLQVQLECS
LHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRD
ALSLQFEPVLLPTSTTNFTKIASFTCKAATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNH
FDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHC
GMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFS
ATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEM
KRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIG
PLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPS
WEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNT
PQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKN
LTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISR
KNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGV
APVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSV
RASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYS
PGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNS
QSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ITPR2-KIAA0922


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ITPR2-KIAA0922


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ITPR2-KIAA0922


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneITPR2C0003132Anoxic Encephalopathy1CTD_human
HgeneITPR2C0018800Cardiomegaly1CTD_human
HgeneITPR2C0995195Anoxia of brain1CTD_human
HgeneITPR2C1140716Hypoxic Brain Damage1CTD_human
HgeneITPR2C1383860Cardiac Hypertrophy1CTD_human
HgeneITPR2C1527348Brain Hypoxia1CTD_human
HgeneITPR2C1862871ANHIDROSIS, ISOLATED, WITH NORMAL SWEAT GLANDS1CTD_human;ORPHANET;UNIPROT