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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KANSL1-NSF (FusionGDB2 ID:40949)

Fusion Gene Summary for KANSL1-NSF

check button Fusion gene summary
Fusion gene informationFusion gene name: KANSL1-NSF
Fusion gene ID: 40949
HgeneTgene
Gene symbol

KANSL1

NSF

Gene ID

284058

4905

Gene nameKAT8 regulatory NSL complex subunit 1N-ethylmaleimide sensitive factor, vesicle fusing ATPase
SynonymsCENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1SEC18|SKD2
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionKAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homologvesicle-fusing ATPaseN-ethylmaleimide-sensitive factor-like proteinN-ethylmaleimide-sensitive fusion proteinNEM-sensitive fusion proteinepididymis secretory sperm binding proteinvesicular-fusion protein NSF
Modification date2020032720200313
UniProtAcc

Q7Z3B3

NSFL1C

Ensembl transtripts involved in fusion geneENST00000574590, ENST00000575318, 
ENST00000572904, ENST00000262419, 
ENST00000432791, ENST00000393476, 
ENST00000576248, 		ENST00000398238, 
ENST00000225282, ENST00000575068, 
Fusion gene scores* DoF score34 X 33 X 14=1570811 X 8 X 6=528
# samples 4712
** MAII scorelog2(47/15708*10)=-5.0626949361014
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KANSL1 [Title/Abstract] AND NSF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKANSL1(44144915)-NSF(44827139), # samples:1
KANSL1(44248221)-NSF(44701610), # samples:1
Anticipated loss of major functional domain due to fusion event.KANSL1-NSF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KANSL1-NSF seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KANSL1-NSF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKANSL1

GO:0043981

histone H4-K5 acetylation

20018852

HgeneKANSL1

GO:0043982

histone H4-K8 acetylation

20018852

HgeneKANSL1

GO:0043984

histone H4-K16 acetylation

20018852

TgeneNSF

GO:0001921

positive regulation of receptor recycling

15613468


check buttonFusion gene breakpoints across KANSL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NSF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A3IQ-01AKANSL1chr17

44144915

-NSFchr17

44827139

+
ChimerDB4PRADTCGA-V1-A9O9KANSL1chr17

44248221

-NSFchr17

44701610

+


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Fusion Gene ORF analysis for KANSL1-NSF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000574590ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000574590ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000574590ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000575318ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000575318ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000575318ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000572904ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000572904ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000572904ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
In-frameENST00000262419ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
In-frameENST00000262419ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
In-frameENST00000262419ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000432791ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000432791ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000432791ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
5UTR-3CDSENST00000393476ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
5UTR-3CDSENST00000393476ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
5UTR-3CDSENST00000393476ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
intron-3CDSENST00000576248ENST00000398238KANSL1chr17

44144915

-NSFchr17

44827139

+
intron-3CDSENST00000576248ENST00000225282KANSL1chr17

44144915

-NSFchr17

44827139

+
intron-3CDSENST00000576248ENST00000575068KANSL1chr17

44144915

-NSFchr17

44827139

+
Frame-shiftENST00000574590ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000574590ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000574590ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+
In-frameENST00000575318ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000575318ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000575318ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+
Frame-shiftENST00000572904ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000572904ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000572904ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+
In-frameENST00000262419ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000262419ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000262419ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+
In-frameENST00000432791ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000432791ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5CDS-5UTRENST00000432791ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+
5UTR-3CDSENST00000393476ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5UTR-5UTRENST00000393476ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5UTR-5UTRENST00000393476ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+
5UTR-3CDSENST00000576248ENST00000398238KANSL1chr17

44248221

-NSFchr17

44701610

+
5UTR-5UTRENST00000576248ENST00000225282KANSL1chr17

44248221

-NSFchr17

44701610

+
5UTR-5UTRENST00000576248ENST00000575068KANSL1chr17

44248221

-NSFchr17

44701610

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262419KANSL1chr1744144915-ENST00000398238NSFchr1744827139+409121234712330619
ENST00000262419KANSL1chr1744144915-ENST00000225282NSFchr1744827139+295121234712330619
ENST00000262419KANSL1chr1744144915-ENST00000575068NSFchr1744827139+268621234712330619
ENST00000575318KANSL1chr1744248221-ENST00000398238NSFchr1744701610+5187132313263545739
ENST00000262419KANSL1chr1744248221-ENST00000398238NSFchr1744701610+5624176017633982739
ENST00000432791KANSL1chr1744248221-ENST00000398238NSFchr1744701610+5238137413773596739

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262419ENST00000398238KANSL1chr1744144915-NSFchr1744827139+0.0030949550.996905
ENST00000262419ENST00000225282KANSL1chr1744144915-NSFchr1744827139+0.0092382920.9907617
ENST00000262419ENST00000575068KANSL1chr1744144915-NSFchr1744827139+0.0108883090.9891117
ENST00000575318ENST00000398238KANSL1chr1744248221-NSFchr1744701610+0.0030312250.9969688
ENST00000262419ENST00000398238KANSL1chr1744248221-NSFchr1744701610+0.0031216150.9968784
ENST00000432791ENST00000398238KANSL1chr1744248221-NSFchr1744701610+0.0030937760.9969062

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Fusion Genomic Features for KANSL1-NSF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KANSL1chr1744248220-NSFchr1744701609+4.50E-060.99999547
KANSL1chr1744144914-NSFchr1744827138+4.96E-070.9999995
KANSL1chr1744248220-NSFchr1744701609+4.50E-060.99999547
KANSL1chr1744144914-NSFchr1744827138+4.96E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KANSL1-NSF


check button Go to

FGviewer for the breakpoints of chr17:44144915-chr17:44827139

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KANSL1

Q7Z3B3

NSF

NSFL1C

FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026}.370

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKANSL1chr17:44144915chr17:44827139ENST00000262419-515283_314550.66666666666661106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44144915chr17:44827139ENST00000432791-414283_314550.66666666666661106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44144915chr17:44827139ENST00000572904-515283_314550.66666666666661106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44144915chr17:44827139ENST00000574590-515283_314550.66666666666661106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44248221chr17:44701610ENST00000262419-215283_314429.66666666666671106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44248221chr17:44701610ENST00000432791-114283_314429.66666666666671106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44248221chr17:44701610ENST00000572904-215283_314429.66666666666671106.0Coiled coilOntology_term=ECO:0000255
HgeneKANSL1chr17:44248221chr17:44701610ENST00000574590-215283_314429.66666666666671106.0Coiled coilOntology_term=ECO:0000255
TgeneNSFchr17:44248221chr17:44701610ENST00000398238021505_5104.0745.0Nucleotide bindingATP
TgeneNSFchr17:44248221chr17:44701610ENST00000398238021545_5524.0745.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKANSL1chr17:44144915chr17:44827139ENST00000262419-515850_882550.66666666666661106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44144915chr17:44827139ENST00000432791-414850_882550.66666666666661106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44144915chr17:44827139ENST00000572904-515850_882550.66666666666661106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44144915chr17:44827139ENST00000574590-515850_882550.66666666666661106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44248221chr17:44701610ENST00000262419-215850_882429.66666666666671106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44248221chr17:44701610ENST00000432791-114850_882429.66666666666671106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44248221chr17:44701610ENST00000572904-215850_882429.66666666666671106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
HgeneKANSL1chr17:44248221chr17:44701610ENST00000574590-215850_882429.66666666666671106.0RegionNote=Required for activation of KAT8 histone acetyltransferase activity
TgeneNSFchr17:44144915chr17:44827139ENST000003982381621505_510636.0745.0Nucleotide bindingATP
TgeneNSFchr17:44144915chr17:44827139ENST000003982381621545_552636.0745.0Nucleotide bindingATP


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Fusion Gene Sequence for KANSL1-NSF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262419_ENST00000398238_TCGA-DK-A3IQ-01A_KANSL1_chr17_44144915_-_NSF_chr17_44827139_length(transcript)=4091nt_BP=2123nt
TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC
AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG
GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT
GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC
ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA
CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT
CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC
ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC
TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC
TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG
AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC
ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG
GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT
GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG
GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC
ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA
TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC
TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT
ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT
GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGCTGCAGACCGGGCA
GCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACATTTACAAACAGATA
CGTGCTAATAAGGGGTTGATAGTTCTTGGGGAGGTACCTCCCCCAGAGCATACAACAGACTTATTTCTTCCACTTAGTTCTGAGGTGAAG
ACAGATCATGGGACTGATAAATTGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTGGTCATATTTCAGAGTCA
CTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCA
AAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAG
CTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGA
AGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTA
GCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACT
GTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCT
TATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATT
CCTTCTTGCTCAGTCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAA
AACTCTCAGTCAGTGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCG
AGGTGTGGGCCAGAGATCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTGGTA
TTCTCTTTGCCTGAAGAAACAAGGCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAAGAT
CTTTCTTAATAGAAAGTCAGATGACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGCTCA
TTATTACCACTTAGAAGATGTTGTTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAAAGT
AATTTACAAACCTCTCAGCACTAATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTGCTT
TTTCCTTAGCTTAATGACTTACTTAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAAAAA
TCAATCATTTTCTAGCCCTCTCCCTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTTCCA
AAAGGAAGCACCCGTTGAGTCCTTTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTGATG
AGACTTATGGAGTGTGCCTCTCTCTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCACAC
GCCACCCATGAGGCTTGTGGCCACAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAAATC
TTGCCATTTGTATACTTTTGGTGGAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTAAAG
AAGTGGATTGTATTGTGAGATCCTGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAAGCA
GCACACATTGTGTTAACTTATGTCTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTTAAT

>In-frame_ENST00000262419_ENST00000398238_TCGA-DK-A3IQ-01A_KANSL1_chr17_44144915_-_NSF_chr17_44827139_length(amino acids)=619AA_start in transcript=471_stop in transcript=2330
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN
WLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGARIIGHISESLSTKSCG

--------------------------------------------------------------
>In-frame_ENST00000262419_ENST00000225282_TCGA-DK-A3IQ-01A_KANSL1_chr17_44144915_-_NSF_chr17_44827139_length(transcript)=2951nt_BP=2123nt
TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC
AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG
GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT
GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC
ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA
CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT
CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC
ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC
TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC
TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG
AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC
ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG
GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT
GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG
GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC
ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA
TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC
TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT
ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT
GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGCTGCAGACCGGGCA
GCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACATTTACAAACAGATA
CGTGCTAATAAGGGGTTGATAGTTCTTGGGGAGGTACCTCCCCCAGAGCATACAACAGACTTATTTCTTCCACTTAGTTCTGAGGTGAAG
ACAGATCATGGGACTGATAAATTGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTGGTCATATTTCAGAGTCA
CTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCA
AAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAG
CTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGA
AGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCGT
AATAGCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTT
CACTGTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCT
TCCTTATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGT
GATTCCTTCTTGCTCAGTCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCT
TGAAAACTCTCAGTCAGTGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAA

>In-frame_ENST00000262419_ENST00000225282_TCGA-DK-A3IQ-01A_KANSL1_chr17_44144915_-_NSF_chr17_44827139_length(amino acids)=619AA_start in transcript=471_stop in transcript=2330
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN
WLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGARIIGHISESLSTKSCG

--------------------------------------------------------------
>In-frame_ENST00000262419_ENST00000575068_TCGA-DK-A3IQ-01A_KANSL1_chr17_44144915_-_NSF_chr17_44827139_length(transcript)=2686nt_BP=2123nt
TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC
AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG
GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT
GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC
ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA
CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT
CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC
ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC
TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC
TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG
AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC
ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG
GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT
GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG
GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC
ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA
TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC
TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT
ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT
GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGCTGCAGACCGGGCA
GCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACATTTACAAACAGATA
CGTGCTAATAAGGGGTTGATAGTTCTTGGGGAGGTACCTCCCCCAGAGCATACAACAGACTTATTTCTTCCACTTAGTTCTGAGGTGAAG
ACAGATCATGGGACTGATAAATTGATTGAGTCTGTTTCTCAGCCATTGGAAAACCATGGTGCCCGTATTATTGGTCATATTTCAGAGTCA
CTGTCTACCAAATCATGTGGAGCACTCAGACCTGTCAATGGAGTTATTAACACGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCA
AAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAG
CTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGA
AGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTA
GCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACT
GTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCT

>In-frame_ENST00000262419_ENST00000575068_TCGA-DK-A3IQ-01A_KANSL1_chr17_44144915_-_NSF_chr17_44827139_length(amino acids)=619AA_start in transcript=471_stop in transcript=2330
MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV
PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK
RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL
SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE
TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN
WLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEVPPPEHTTDLFLPLSSEVKTDHGTDKLIESVSQPLENHGARIIGHISESLSTKSCG

--------------------------------------------------------------
>In-frame_ENST00000575318_ENST00000398238_TCGA-V1-A9O9_KANSL1_chr17_44248221_-_NSF_chr17_44701610_length(transcript)=5187nt_BP=1323nt
GGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCG
GTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAAC
CAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGT
GGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAA
ATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAG
AACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGA
TCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGG
GGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGC
AAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGG
GGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCG
GCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACA
TCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAA
GGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGA
ATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGG
GGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTAGCATGCAAGCGGCAAGATGTCCTACA
GATGAATTATCTTTAACCAATTGTGCAGTTGTGAATGAAAAGGATTTCCAGTCTGGCCAGCATGTGATTGTGAGGACCTCTCCCAATCAC
AGGTACACATTTACACTGAAGACACATCCATCGGTGGTTCCAGGGAGCATTGCATTCAGTTTACCTCAGAGAAAATGGGCTGGGCTTTCT
ATTGGGCAAGAAATAGAAGTCTCCTTATATACATTTGACAAAGCCAAACAGTGTATTGGCACAATGACCATCGAGATTGATTTCCTGCAG
AAAAAAAGCATTGACTCCAACCCTTATGACACCGACAAGATGGCAGCAGAATTTATTCAGCAATTCAACAACCAGGCCTTCTCAGTGGGA
CAACAGCTTGTCTTTAGCTTCAATGAAAAGCTTTTTGGCTTACTGGTGAAGGACATTGAAGCCATGGATCCTAGCATCCTGAAGGGAGAG
CCTGCGACAGGGAAAAGGCAGAAGATTGAAGTAGGACTGGTTGTTGGAAACAGTCAAGTTGCATTTGAAAAAGCAGAAAATTCGTCACTT
AATCTTATTGGCAAAGCTAAAACCAAGGAAAATCGCCAATCAATTATCAATCCTGACTGGAACTTTGAAAAAATGGGAATAGGAGGTCTA
GACAAGGAATTTTCAGATATTTTCCGACGAGCATTTGCTTCCCGAGTATTTCCTCCAGAGATTGTGGAGCAGATGGGTTGTAAACATGTT
AAAGGCATCCTGTTATATGGACCCCCAGGTTGTGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAA
GTGGTCAATGGGCCAGAAATCCTTAACAAATATGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAA
AGGAGGCTTGGTGCTAACAGTGGTTTGCACATCATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGC
ACGGGAGTTCATGACACTGTTGTCAACCAGTTGCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACC
AATAGACCAGATCTGATAGATGAGGCTCTTCTTAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGA
CTACAGATTCTTCACATCCACACAGCAAGAATGAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACC
AAGAATTTCAGTGGTGCTGAATTGGAGGGTCTGGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTG
GAAGTGGACATGGAGAAAGCAGAAAGCCTGCAAGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGC
ACAAACCAAGAAGATTATGCAAGTTACATTATGAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTG
CTGGTGCAGCAGACTAAGAACAGTGACCGCACACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCT
GCAAAAATTGCAGAGGAATCCAACTTCCCGTTCATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAG
GCCATGAAGAAGATCTTTGATGATGCGTACAAATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCT
ATTGGCCCTCGATTTTCAAATCTTGTATTACAGGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATT
GGGACCACTAGCCGCAAAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGA
GAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTC
TGGATAGGAATCAAGAAGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTA
AGAGAAGAAGGAGCTAGCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATG
GCCTAGGATCTTCACTGTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCA
ATAAAACTCCCTTCCTTATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCAT
GCAGGCTAAAGTGATTCCTTCTTGCTCAGTCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAG
CACCATCACCCTTGAAAACTCTCAGTCAGTGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAAT
CTGGCTTAGTAAATCGAGGTGTGGGCCAGAGATCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTC
TCCCACAAGACTGGTATTCTCTTTGCCTGAAGAAACAAGGCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAA
GTTGCAGTCAGAAGATCTTTCTTAATAGAAAGTCAGATGACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTG
GTAAGAGATATGCTCATTATTACCACTTAGAAGATGTTGTTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGA
AAGGAGTTATTAAAGTAATTTACAAACCTCTCAGCACTAATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTT
ACTAGTATCACTGCTTTTTCCTTAGCTTAATGACTTACTTAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACA
CTATTCTCCAGAAAAATCAATCATTTTCTAGCCCTCTCCCTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCT
CCACACACTTCTTCCAAAAGGAAGCACCCGTTGAGTCCTTTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAG
GTCATATTTGGTGATGAGACTTATGGAGTGTGCCTCTCTCTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAA
GGTGCTTACCTCACACGCCACCCATGAGGCTTGTGGCCACAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGC
AGATCATCTCCAAATCTTGCCATTTGTATACTTTTGGTGGAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTAT
TTTGTGGCTTTTAAAGAAGTGGATTGTATTGTGAGATCCTGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTT
CCTCCTCATGAAAGCAGCACACATTGTGTTAACTTATGTCTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGA

>In-frame_ENST00000575318_ENST00000398238_TCGA-V1-A9O9_KANSL1_chr17_44248221_-_NSF_chr17_44701610_length(amino acids)=739AA_start in transcript=1326_stop in transcript=3545
MQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTM
TIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAF
EKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGK
MLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLN
NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR
HIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPP
HSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPP
QGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYR

--------------------------------------------------------------
>In-frame_ENST00000262419_ENST00000398238_TCGA-V1-A9O9_KANSL1_chr17_44248221_-_NSF_chr17_44701610_length(transcript)=5624nt_BP=1760nt
TCCTCCTCCTCCTGCTGCCCTTTCTCCTTCTCCTCGCTCTCCCTGTGGCTCCCATTTCTCTCTCTCTTTGTTAGTTGTAACTAGAAAGGC
AGGGCAGGGTAGAAAAATCCCCCGGAACTTTAAATGGCCTCTCCGGGCTTCCCTGCTGCGGGTCCGGGCTGGGAGTCGCCCCAAGGGCGG
GGGTGTGCGGGGGCCCTTCCCCAGGAGCTGCCGCCTCGTTCGCCAGCTTTTCCTTTGGCGTTCTATTTAAAAAGGCGGCCTGAAGAACAT
GATTTATTCCCGTAAAAGAACCCCCCAAACAAACTCTGGCTCTCGCCTTGAACTTCTCTTGACTGCAAAAGGCCTTTCTCTGCTCGAAAC
ACACATCTTGGCGCGTTGCACGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGA
CTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCT
CCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCC
ATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTC
TGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTC
TTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACG
AGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCC
ACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGG
GGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCT
GTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTG
GAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGAC
ATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGA
TTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCC
TTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTT
ACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATT
GAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTAGCATGCAAGCGGCAAGATGTCCTACAGATGAATTATCTT
TAACCAATTGTGCAGTTGTGAATGAAAAGGATTTCCAGTCTGGCCAGCATGTGATTGTGAGGACCTCTCCCAATCACAGGTACACATTTA
CACTGAAGACACATCCATCGGTGGTTCCAGGGAGCATTGCATTCAGTTTACCTCAGAGAAAATGGGCTGGGCTTTCTATTGGGCAAGAAA
TAGAAGTCTCCTTATATACATTTGACAAAGCCAAACAGTGTATTGGCACAATGACCATCGAGATTGATTTCCTGCAGAAAAAAAGCATTG
ACTCCAACCCTTATGACACCGACAAGATGGCAGCAGAATTTATTCAGCAATTCAACAACCAGGCCTTCTCAGTGGGACAACAGCTTGTCT
TTAGCTTCAATGAAAAGCTTTTTGGCTTACTGGTGAAGGACATTGAAGCCATGGATCCTAGCATCCTGAAGGGAGAGCCTGCGACAGGGA
AAAGGCAGAAGATTGAAGTAGGACTGGTTGTTGGAAACAGTCAAGTTGCATTTGAAAAAGCAGAAAATTCGTCACTTAATCTTATTGGCA
AAGCTAAAACCAAGGAAAATCGCCAATCAATTATCAATCCTGACTGGAACTTTGAAAAAATGGGAATAGGAGGTCTAGACAAGGAATTTT
CAGATATTTTCCGACGAGCATTTGCTTCCCGAGTATTTCCTCCAGAGATTGTGGAGCAGATGGGTTGTAAACATGTTAAAGGCATCCTGT
TATATGGACCCCCAGGTTGTGGTAAGACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGC
CAGAAATCCTTAACAAATATGTGGGAGAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTG
CTAACAGTGGTTTGCACATCATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATG
ACACTGTTGTCAACCAGTTGCTGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATC
TGATAGATGAGGCTCTTCTTAGACCTGGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTC
ACATCCACACAGCAAGAATGAGAGGGCATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTG
GTGCTGAATTGGAGGGTCTGGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGG
AGAAAGCAGAAAGCCTGCAAGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAG
ATTATGCAAGTTACATTATGAACGGTATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGA
CTAAGAACAGTGACCGCACACCATTGGTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAG
AGGAATCCAACTTCCCGTTCATCAAGATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGA
TCTTTGATGATGCGTACAAATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGAT
TTTCAAATCTTGTATTACAGGCTCTTCTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCC
GCAAAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGG
AAGCTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCA
AGAAGTTACTAATGCTGATCGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAG
CTAGCCCCCTTGATTTTGATTGAAAATGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTC
ACTGTCTTACTCAAGATACTGGACTAAGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTT
CCTTATGCATACTGAGATAGCTTAGTGTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTG
ATTCCTTCTTGCTCAGTCCCTCTGGGTGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTT
GAAAACTCTCAGTCAGTGTCATGAATGTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAA
TCGAGGTGTGGGCCAGAGATCCTCTGACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTG
GTATTCTCTTTGCCTGAAGAAACAAGGCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAA
GATCTTTCTTAATAGAAAGTCAGATGACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGC
TCATTATTACCACTTAGAAGATGTTGTTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAA
AGTAATTTACAAACCTCTCAGCACTAATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTG
CTTTTTCCTTAGCTTAATGACTTACTTAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAA
AAATCAATCATTTTCTAGCCCTCTCCCTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTT
CCAAAAGGAAGCACCCGTTGAGTCCTTTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTG
ATGAGACTTATGGAGTGTGCCTCTCTCTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCA
CACGCCACCCATGAGGCTTGTGGCCACAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAA
ATCTTGCCATTTGTATACTTTTGGTGGAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTA
AAGAAGTGGATTGTATTGTGAGATCCTGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAA
GCAGCACACATTGTGTTAACTTATGTCTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTT

>In-frame_ENST00000262419_ENST00000398238_TCGA-V1-A9O9_KANSL1_chr17_44248221_-_NSF_chr17_44701610_length(amino acids)=739AA_start in transcript=1763_stop in transcript=3982
MQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTM
TIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAF
EKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGK
MLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLN
NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR
HIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPP
HSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPP
QGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYR

--------------------------------------------------------------
>In-frame_ENST00000432791_ENST00000398238_TCGA-V1-A9O9_KANSL1_chr17_44248221_-_NSF_chr17_44701610_length(transcript)=5238nt_BP=1374nt
TTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGC
TGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGG
CAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGA
TTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTC
AAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGC
TGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGC
ACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGC
TCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACA
TAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACT
TCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTC
CATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACA
AAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACT
GCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCAC
CACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAG
GTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGA
TCCCGAGCAGCGTCATGTACCCCTAGCATGCAAGCGGCAAGATGTCCTACAGATGAATTATCTTTAACCAATTGTGCAGTTGTGAATGAA
AAGGATTTCCAGTCTGGCCAGCATGTGATTGTGAGGACCTCTCCCAATCACAGGTACACATTTACACTGAAGACACATCCATCGGTGGTT
CCAGGGAGCATTGCATTCAGTTTACCTCAGAGAAAATGGGCTGGGCTTTCTATTGGGCAAGAAATAGAAGTCTCCTTATATACATTTGAC
AAAGCCAAACAGTGTATTGGCACAATGACCATCGAGATTGATTTCCTGCAGAAAAAAAGCATTGACTCCAACCCTTATGACACCGACAAG
ATGGCAGCAGAATTTATTCAGCAATTCAACAACCAGGCCTTCTCAGTGGGACAACAGCTTGTCTTTAGCTTCAATGAAAAGCTTTTTGGC
TTACTGGTGAAGGACATTGAAGCCATGGATCCTAGCATCCTGAAGGGAGAGCCTGCGACAGGGAAAAGGCAGAAGATTGAAGTAGGACTG
GTTGTTGGAAACAGTCAAGTTGCATTTGAAAAAGCAGAAAATTCGTCACTTAATCTTATTGGCAAAGCTAAAACCAAGGAAAATCGCCAA
TCAATTATCAATCCTGACTGGAACTTTGAAAAAATGGGAATAGGAGGTCTAGACAAGGAATTTTCAGATATTTTCCGACGAGCATTTGCT
TCCCGAGTATTTCCTCCAGAGATTGTGGAGCAGATGGGTTGTAAACATGTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGTGGTAAG
ACTCTCTTGGCTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATGGGCCAGAAATCCTTAACAAATATGTGGGA
GAATCAGAGGCTAACATTCGCAAACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTGGTTTGCACATCATCATC
TTTGATGAAATTGATGCCATCTGCAAGCAGAGAGGGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTGCTGTCC
AAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAATGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTTAGACCT
GGAAGACTGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAGATTCTTCACATCCACACAGCAAGAATGAGAGGG
CATCAGTTACTCTCTGCTGATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCTGAATTGGAGGGTCTGGTGCGA
GCAGCCCAGTCCACTGCTATGAATAGACACATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCTGCAAGTGACG
AGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACCAGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATGAACGGT
ATCATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCTGGTGCAGCAGACTAAGAACAGTGACCGCACACCATTG
GTCAGCGTGCTTCTGGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGAGGAATCCAACTTCCCGTTCATCAAG
ATCTGTTCTCCTGATAAAATGATTGGCTTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCGTACAAATCCCAG
CTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTGATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAGGCTCTT
CTCGTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGGACCACTAGCCGCAAAGATGTCCTTCAGGAGATGGAA
ATGCTTAACGCTTTCAGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAAGCTTTGGAGCTTTTGGGCAACTTC
AAGGATAAGGAACGCACCACAATTGCACAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAATGCTGATCGAGATG
TCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATTCTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGATTGAAAA
TGAACTATTTGAAACACACAGTGACCAAGGGAAGTGACCAAGGTGAAGATGGCCTAGGATCTTCACTGTCTTACTCAAGATACTGGACTA
AGTGGAACGTTCTCTACCTTCAACATGTGCTCGCTCTGCATGATTAGTGCAATAAAACTCCCTTCCTTATGCATACTGAGATAGCTTAGT
GTCTCGTGGAAGGTGTCAATTTGGTTTAGAATGCTGCGCTTACCTTCCCATGCAGGCTAAAGTGATTCCTTCTTGCTCAGTCCCTCTGGG
TGGGAACCATCCAGTACTTGTGGACACTACACGTTTCAACCTCTCTACTAGCACCATCACCCTTGAAAACTCTCAGTCAGTGTCATGAAT
GTTGCATGACAACAGTTGGCCGATTAGAAGGCAGACTTTCTACATGCAAATCTGGCTTAGTAAATCGAGGTGTGGGCCAGAGATCCTCTG
ACAGCTGTCCTGAGCTAACACTAAAAGTCACTGGGTATTTGGTTAAAGGTCTCCCACAAGACTGGTATTCTCTTTGCCTGAAGAAACAAG
GCATTGAATCTCTAAAATGCTGTTCTCAATCATTGTCAGAGATGTTTTCAAGTTGCAGTCAGAAGATCTTTCTTAATAGAAAGTCAGATG
ACTACCGTGTTGGTTGTGACTTCCCCTTAAGTATAACTAATTTGCTCTGTGGTAAGAGATATGCTCATTATTACCACTTAGAAGATGTTG
TTAAAAACATGTGAAAGATAGGTATGGAAAAAGCATACACCCCCAAACAGAAAGGAGTTATTAAAGTAATTTACAAACCTCTCAGCACTA
ATTAGTGTCCAACTCCAAGTGGGTCAATTCCTTAGTATAATATTAAGGCTTACTAGTATCACTGCTTTTTCCTTAGCTTAATGACTTACT
TAGAATTTATCCTTTATTTTAAATGATCTGTACTATCTAGTGTCTAAAACACTATTCTCCAGAAAAATCAATCATTTTCTAGCCCTCTCC
CTCAGTCCTTTATTGTCCATTCCAATACATTGAACACATTTCCTTTACCCTCCACACACTTCTTCCAAAAGGAAGCACCCGTTGAGTCCT
TTTGAGGGTGATTTGTCTTACAACTGACTGACTTAGCAGGAATTTAATTAGGTCATATTTGGTGATGAGACTTATGGAGTGTGCCTCTCT
CTCCCAACTGCTGCTTAAAATGCAAGGACAAGCAATTAGAAGCCATCCTAAGGTGCTTACCTCACACGCCACCCATGAGGCTTGTGGCCA
CAGTGGCACTTGGGTGTGGCTCCTCTGTTATTTGTCCTCATGTGAGAAAGCAGATCATCTCCAAATCTTGCCATTTGTATACTTTTGGTG
GAGACTTGGATGTCATATCTTCTTTGTTTTGGGTTTTCTTCCCTAGCTTATTTTGTGGCTTTTAAAGAAGTGGATTGTATTGTGAGATCC
TGTGATTCCTGGTGGCCAGTATCCTGGATTCCTCTAAGATCTTGCCTCTTTCCTCCTCATGAAAGCAGCACACATTGTGTTAACTTATGT
CTCTTGTTAAATGAGCTTAATGTCTTTGTGTTTTGTCCAAAACTGTATTGAAAAAATATTGTTTAATGCAAATGAAGGAATGCAATAAAG

>In-frame_ENST00000432791_ENST00000398238_TCGA-V1-A9O9_KANSL1_chr17_44248221_-_NSF_chr17_44701610_length(amino acids)=739AA_start in transcript=1377_stop in transcript=3596
MQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTM
TIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAF
EKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGK
MLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLN
NILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR
HIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPP
HSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPP
QGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KANSL1-NSF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KANSL1-NSF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KANSL1-NSF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKANSL1C0020796Profound Mental Retardation2CTD_human
HgeneKANSL1C0025363Mental Retardation, Psychosocial2CTD_human
HgeneKANSL1C0026825Flaccid Muscle Tone2CTD_human
HgeneKANSL1C0026827Muscle hypotonia2CTD_human
HgeneKANSL1C0376634Craniofacial Abnormalities2CTD_human
HgeneKANSL1C0427201Floppy Muscles2CTD_human
HgeneKANSL1C0427202Muscle Tone Atonic2CTD_human
HgeneKANSL1C0751330Unilateral Hypotonia2CTD_human
HgeneKANSL1C0917816Mental deficiency2CTD_human
HgeneKANSL1C1864871Chromosome 17q21.31 Deletion Syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKANSL1C2267233Neonatal Hypotonia2CTD_human
HgeneKANSL1C2931713Chromosome 17 deletion2CTD_human
HgeneKANSL1C3683846Chromosome 17p Deletion Syndrome2CTD_human
HgeneKANSL1C3714756Intellectual Disability2CTD_human
HgeneKANSL1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKANSL1C0919267ovarian neoplasm1CTD_human
HgeneKANSL1C1140680Malignant neoplasm of ovary1CTD_human
HgeneKANSL1C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
TgeneNSFC0036572Seizures1GENOMICS_ENGLAND
TgeneNSFC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneNSFC0600427Cocaine Dependence1PSYGENET
TgeneNSFC1969156EEG with burst suppression1GENOMICS_ENGLAND
TgeneNSFC3714756Intellectual Disability1GENOMICS_ENGLAND