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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:KANSL1-PHF20 (FusionGDB2 ID:40954) |
Fusion Gene Summary for KANSL1-PHF20 |
Fusion gene summary |
Fusion gene information | Fusion gene name: KANSL1-PHF20 | Fusion gene ID: 40954 | Hgene | Tgene | Gene symbol | KANSL1 | PHF20 | Gene ID | 284058 | 51230 |
Gene name | KAT8 regulatory NSL complex subunit 1 | PHD finger protein 20 | |
Synonyms | CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1 | C20orf104|GLEA2|HCA58|NZF|TDRD20A|TZP | |
Cytomap | 17q21.31 | 20q11.22-q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog | PHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20A | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | Q7Z3B3 | . | |
Ensembl transtripts involved in fusion gene | ENST00000574590, ENST00000575318, ENST00000572904, ENST00000262419, ENST00000432791, ENST00000393476, ENST00000576248, | ENST00000374012, ENST00000439301, ENST00000481202, | |
Fusion gene scores | * DoF score | 34 X 33 X 14=15708 | 26 X 25 X 15=9750 |
# samples | 47 | 32 | |
** MAII score | log2(47/15708*10)=-5.0626949361014 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(32/9750*10)=-4.92925840863697 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: KANSL1 [Title/Abstract] AND PHF20 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | KANSL1(44171925)-PHF20(34515701), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | KANSL1-PHF20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KANSL1-PHF20 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KANSL1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
Hgene | KANSL1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
Hgene | KANSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
Tgene | PHF20 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
Tgene | PHF20 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
Tgene | PHF20 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
Fusion gene breakpoints across KANSL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PHF20 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A2-A25F | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
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Fusion Gene ORF analysis for KANSL1-PHF20 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000574590 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-3UTR | ENST00000574590 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-intron | ENST00000574590 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
In-frame | ENST00000575318 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-3UTR | ENST00000575318 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-intron | ENST00000575318 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
Frame-shift | ENST00000572904 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-3UTR | ENST00000572904 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-intron | ENST00000572904 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
Frame-shift | ENST00000262419 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-3UTR | ENST00000262419 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-intron | ENST00000262419 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
In-frame | ENST00000432791 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-3UTR | ENST00000432791 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5CDS-intron | ENST00000432791 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5UTR-3CDS | ENST00000393476 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5UTR-3UTR | ENST00000393476 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
5UTR-intron | ENST00000393476 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
intron-3CDS | ENST00000576248 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
intron-3UTR | ENST00000576248 | ENST00000439301 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
intron-intron | ENST00000576248 | ENST00000481202 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000574590 | KANSL1 | chr17 | 44171925 | - | ENST00000374012 | PHF20 | chr20 | 34515701 | + | 5447 | 1658 | 227 | 2692 | 821 |
ENST00000575318 | KANSL1 | chr17 | 44171925 | - | ENST00000374012 | PHF20 | chr20 | 34515701 | + | 5254 | 1465 | 34 | 2499 | 821 |
ENST00000432791 | KANSL1 | chr17 | 44171925 | - | ENST00000374012 | PHF20 | chr20 | 34515701 | + | 5305 | 1516 | 85 | 2550 | 821 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000574590 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + | 0.00140626 | 0.99859375 |
ENST00000575318 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + | 0.00151366 | 0.9984863 |
ENST00000432791 | ENST00000374012 | KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + | 0.001562568 | 0.99843746 |
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Fusion Genomic Features for KANSL1-PHF20 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + | 0.000783191 | 0.9992168 |
KANSL1 | chr17 | 44171925 | - | PHF20 | chr20 | 34515701 | + | 0.000783191 | 0.9992168 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KANSL1-PHF20 |
Go to FGviewer for the breakpoints of chr17:44171925-chr20:34515701 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
KANSL1 | . |
FUNCTION: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000262419 | - | 3 | 15 | 283_314 | 477.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000432791 | - | 2 | 14 | 283_314 | 477.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000572904 | - | 3 | 15 | 283_314 | 477.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000574590 | - | 3 | 15 | 283_314 | 477.0 | 1106.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 654_700 | 646.3333333333334 | 1356.0 | Zinc finger | Note=PHD-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000262419 | - | 3 | 15 | 850_882 | 477.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000432791 | - | 2 | 14 | 850_882 | 477.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000572904 | - | 3 | 15 | 850_882 | 477.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
Hgene | KANSL1 | chr17:44171925 | chr20:34515701 | ENST00000574590 | - | 3 | 15 | 850_882 | 477.0 | 1106.0 | Region | Note=Required for activation of KAT8 histone acetyltransferase activity |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 162_221 | 668.0 | 1013.0 | Compositional bias | Note=Lys-rich | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 523_552 | 668.0 | 1013.0 | Compositional bias | Note=Lys-rich | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 162_221 | 646.3333333333334 | 1356.0 | Compositional bias | Note=Lys-rich | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 523_552 | 646.3333333333334 | 1356.0 | Compositional bias | Note=Lys-rich | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 257_269 | 668.0 | 1013.0 | DNA binding | Note=A.T hook | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 257_269 | 646.3333333333334 | 1356.0 | DNA binding | Note=A.T hook | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 4_69 | 668.0 | 1013.0 | Domain | Note=Tudor 1 | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 83_147 | 668.0 | 1013.0 | Domain | Note=Tudor 2 | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 4_69 | 646.3333333333334 | 1356.0 | Domain | Note=Tudor 1 | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 83_147 | 646.3333333333334 | 1356.0 | Domain | Note=Tudor 2 | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 452_477 | 668.0 | 1013.0 | Zinc finger | C2H2-type | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000374012 | 12 | 18 | 654_700 | 668.0 | 1013.0 | Zinc finger | Note=PHD-type | |
Tgene | PHF20 | chr17:44171925 | chr20:34515701 | ENST00000439301 | 13 | 19 | 452_477 | 646.3333333333334 | 1356.0 | Zinc finger | C2H2-type |
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Fusion Gene Sequence for KANSL1-PHF20 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000574590_ENST00000374012_TCGA-A2-A25F_KANSL1_chr17_44171925_-_PHF20_chr20_34515701_length(transcript)=5447nt_BP=1658nt TCAGATACCTTCTCGAAACAAAAGATTTTCCTACCTGCTTATACTTGGTAACCGAGGGAATTACTAAGACTTCTTGCTCATTTCTGAGTA TTGTCTTTATATCCTGACACTATGAATGCTACTTGGATGCCTCTTAAGTCTGTTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCT CGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAG CACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTG CTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGC TGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGC AGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCT TAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTT CAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAG GATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCA ATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCA GCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAA CAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGA GGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGA TGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATT CAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACA GTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAG AATGGAAATGGGCTGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTC AGCAAACAGACATTTACAAACAGATACGTGCTAATAAGTGTGAAGAGTGCCAGTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAG AAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGC TGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTC TTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGC TGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAG CTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCA CCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACG ATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACA GTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACA GAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACA GGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGC TTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGG CACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTTAAATAAATAAACCTAGCATGCTGAATGCACG TGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCT CGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACT TCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTT AATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTC TAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTT CACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTT TGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGG GTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAA TTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTTATTTTATATTGTTGTAAACAAACTTCAAATT CTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATTGTTTTGTTACTATACTTTAACATTTTACATT TCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAACCTATTTGTACCTTTTGAGACAATATTTGTG TTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGA GGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAGTTGTCCATTAACACTTATAAGTTAATTATGG GTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTT TAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTA GTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGC TATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACA GGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAG CCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGG AAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTA TTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCC AAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTA TGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCT GTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTC TCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAA CCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAA AATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATCCACCTATAAAAAATTACCTTGACAAAAATAG TTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCTTGATGAGCCAACATTGCACTGTGGATACATA TCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGCAATATTTGCAAAACACGCAGACTTCTGTATC >In-frame_ENST00000574590_ENST00000374012_TCGA-A2-A25F_KANSL1_chr17_44171925_-_PHF20_chr20_34515701_length(amino acids)=821AA_start in transcript=227_stop in transcript=2692 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN WLQAHVSDLEYRIRQQTDIYKQIRANKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENY SHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRP LALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSK KALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLG -------------------------------------------------------------- >In-frame_ENST00000575318_ENST00000374012_TCGA-A2-A25F_KANSL1_chr17_44171925_-_PHF20_chr20_34515701_length(transcript)=5254nt_BP=1465nt GGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGCTGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCG GTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGGCAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAAC CAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGATTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGT GGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTCAAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAA ATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGCTGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAG AACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGCACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGA TCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGCTCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGG GGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACATAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGC AAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACTTCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGG GGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTCCATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCG GCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACAAAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACA TCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACTGCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAA GGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCACCACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGA ATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAGGTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGG GGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGATCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGC TGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCTTCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACAT TTACAAACAGATACGTGCTAATAAGTGTGAAGAGTGCCAGTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGA GAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACA TATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCA GAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCC TTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAG AACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTG CTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCC CCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACC CGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGG GCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCAT TGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAA GCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCA TGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTTAAATAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGA CTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCAT AAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTG TGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCT ATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGA ATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACC ACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCC ATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAA AGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTT CACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTTATTTTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGAC TTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATTGTTTTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATT ATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAACCTATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGG TTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATT TCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAGTTGTCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTG TAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGG AATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCAC CATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATA ACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCA TGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAG GCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTT TAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGT TTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAAC CTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTG GAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCAC TTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTA CAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGA GGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAG AAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATCCACCTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACT AATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCTTGATGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGC GCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGCAATATTTGCAAAACACGCAGACTTCTGTATCTGTATTTGGAAAA >In-frame_ENST00000575318_ENST00000374012_TCGA-A2-A25F_KANSL1_chr17_44171925_-_PHF20_chr20_34515701_length(amino acids)=821AA_start in transcript=34_stop in transcript=2499 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN WLQAHVSDLEYRIRQQTDIYKQIRANKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENY SHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRP LALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSK KALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLG -------------------------------------------------------------- >In-frame_ENST00000432791_ENST00000374012_TCGA-A2-A25F_KANSL1_chr17_44171925_-_PHF20_chr20_34515701_length(transcript)=5305nt_BP=1516nt TTCTCTGGGGAGGCAGTAAGGGGCCGTGGAGCTGGCCTCGGCCTCGGCATCGGGAGAGGCTGGACTTCCTGTCTCTCTGTGCTGAATGGC TGCGATGGCGCCCGCTCTCACTGACGCAGCAGCTGAAGCACACCATATCCGGTTCAAACTGGCTCCCCCATCCTCTACCTTGTCCCCTGG CAGTGCCGAAAATAACGGCAACGCCAACATCCTTATTGCTGCCAACGGAACCAAAAGAAAAGCCATTGCTGCAGAGGATCCCAGCCTAGA TTTCCGAAATAATCCTACCAAGGAAGACTTGGGAAAGCTGCAACCACTGGTGGCATCTTATCTCTGCTCTGATGTAACATCTGTTCCCTC AAAGGAGTCTTTGAAGTTGCAAGGGGTCTTCAGCAAGCAGACAGTCCTTAAATCTCATCCTCTCTTATCTCAGTCCTATGAACTCCGAGC TGAGCTGTTGGGGAGACAGCCAGTTTTGGAGTTTTCCTTAGAAAATCTTAGAACCATGAATACGAGTGGTCAGACAGCTCTGCCACAAGC ACCTGTAAATGGGTTGGCTAAGAAATTGACTAAAAGTTCAACACATTCTGATCATGACAATTCCACTTCCCTCAATGGGGGAAAACGGGC TCTCACTTCATCTGCTCTTCATGGGGGTGAAATGGGAGGATCTGAATCTGGGGACTTGAAGGGGGGTATGACCAATTGCACTCTTCCACA TAGAAGCCTTGATGTAGAACACACAACTTTGTATAGCAATAATAGCACTGCAAACAAATCCTCTGTCAATTCCATGGAACAGCCGGCACT TCAAGGAAGCAGTAGATTATCACCTGGTACAGACTCCAGCTCTAACTTGGGGGGTGTCAAATTGGAGGGTAAAAAGTCTCCCCTGTCTTC CATTCTTTTCAGTGCTTTAGATTCTGACACAAGGATAACAGCTTTACTGCGGCGACAGGCTGACATTGAGAGCCGTGCCCGCAGATTACA AAAGCGCTTACAGGTTGTGCAAGCCAAGCAGGTTGAGAGGCATATACAACATCAGCTGGGTGGATTTTTGGAGAAGACTTTGAGCAAACT GCCAAACTTGGAATCCTTGAGACCACGGAGCCAGTTGATGCTGACTCGAAAGGCTGAAGCTGCCTTGAGAAAAGCTGCCAGTGAGACCAC CACTTCAGAGGGACTTAGCAACTTTCTGAAAAGCAATTCAATTTCAGAAGAATTGGAGAGATTTACAGCTAGTGGCATAGCCAACTTGAG GTGCAGTGAACAGGCATTTGATTCAGATGTCACTGACAGTAGTTCAGGAGGGGAGTCTGATATTGAAGAGGAAGAACTGACCAGAGCTGA TCCCGAGCAGCGTCATGTACCCCTGAGACGCAGGTCAGAATGGAAATGGGCTGCAGACCGGGCAGCTATTGTCAGCCGCTGGAACTGGCT TCAGGCTCATGTTTCTGACTTGGAATATCGAATTCGTCAGCAAACAGACATTTACAAACAGATACGTGCTAATAAGTGTGAAGAGTGCCA GTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCA GAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCA TCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGAT GAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAG AAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGC CCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCA GAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCT GGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGC CCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCT GACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTA CACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGT GCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCG CATATTTAAATAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGAC AAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGT GCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTT AGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCT GGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAG CAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTT GTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAA TAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCT TCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAA TTACCTTATTTTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTT CAGAATTGTTTTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCA GGTACAACCTATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTT TTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAA AGCACAGTTGTCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGA AGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGC CTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTG ATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACT GCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATG CAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCT TTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGC AGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCAT TGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGC TCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAA ATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGA GTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCT CAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCT CGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAA AACTATCCACCTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGT GGATCCTTGATGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCT >In-frame_ENST00000432791_ENST00000374012_TCGA-A2-A25F_KANSL1_chr17_44171925_-_PHF20_chr20_34515701_length(amino acids)=821AA_start in transcript=85_stop in transcript=2550 MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILIAANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSV PSKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSTSLNGGK RALTSSALHGGEMGGSESGDLKGGMTNCTLPHRSLDVEHTTLYSNNSTANKSSVNSMEQPALQGSSRLSPGTDSSSNLGGVKLEGKKSPL SSILFSALDSDTRITALLRRQADIESRARRLQKRLQVVQAKQVERHIQHQLGGFLEKTLSKLPNLESLRPRSQLMLTRKAEAALRKAASE TTTSEGLSNFLKSNSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQRHVPLRRRSEWKWAADRAAIVSRWN WLQAHVSDLEYRIRQQTDIYKQIRANKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENY SHQNAKKIVATHQLLGDVQRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRP LALPLPRSVEESYITSEHCYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSK KALPEEAPARKLLDRGGEGLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLMDLG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KANSL1-PHF20 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KANSL1-PHF20 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KANSL1-PHF20 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KANSL1 | C0020796 | Profound Mental Retardation | 2 | CTD_human |
Hgene | KANSL1 | C0025363 | Mental Retardation, Psychosocial | 2 | CTD_human |
Hgene | KANSL1 | C0026825 | Flaccid Muscle Tone | 2 | CTD_human |
Hgene | KANSL1 | C0026827 | Muscle hypotonia | 2 | CTD_human |
Hgene | KANSL1 | C0376634 | Craniofacial Abnormalities | 2 | CTD_human |
Hgene | KANSL1 | C0427201 | Floppy Muscles | 2 | CTD_human |
Hgene | KANSL1 | C0427202 | Muscle Tone Atonic | 2 | CTD_human |
Hgene | KANSL1 | C0751330 | Unilateral Hypotonia | 2 | CTD_human |
Hgene | KANSL1 | C0917816 | Mental deficiency | 2 | CTD_human |
Hgene | KANSL1 | C1864871 | Chromosome 17q21.31 Deletion Syndrome | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | KANSL1 | C2267233 | Neonatal Hypotonia | 2 | CTD_human |
Hgene | KANSL1 | C2931713 | Chromosome 17 deletion | 2 | CTD_human |
Hgene | KANSL1 | C3683846 | Chromosome 17p Deletion Syndrome | 2 | CTD_human |
Hgene | KANSL1 | C3714756 | Intellectual Disability | 2 | CTD_human |
Hgene | KANSL1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | KANSL1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | KANSL1 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
Hgene | KANSL1 | C1860789 | Leukemia, Megakaryoblastic, of Down Syndrome | 1 | CTD_human |