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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALG11-ZFYVE28 (FusionGDB2 ID:4097)

Fusion Gene Summary for ALG11-ZFYVE28

check button Fusion gene summary
Fusion gene informationFusion gene name: ALG11-ZFYVE28
Fusion gene ID: 4097
HgeneTgene
Gene symbol

ALG11

ZFYVE28

Gene ID

440138

57732

Gene nameALG11 alpha-1,2-mannosyltransferasezinc finger FYVE-type containing 28
SynonymsCDG1P|GT8LST2|LYST2|lst-2
Cytomap

13q14.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionGDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseGDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferaseasparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homologasparagine-linked glycosylation protein 11 homologglylateral signaling target protein 2 homologhLst2lateral signaling target-2 homologzinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28
Modification date2020031320200313
UniProtAcc

Q2TAA5

.
Ensembl transtripts involved in fusion geneENST00000523764, ENST00000521508, 
ENST00000519151, 		ENST00000290974, 
ENST00000511071, ENST00000515312, 
ENST00000515169, ENST00000509171, 
ENST00000503000, ENST00000508471, 
ENST00000505421, 
Fusion gene scores* DoF score4 X 2 X 3=249 X 8 X 8=576
# samples 49
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/576*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALG11 [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALG11(52586598)-ZFYVE28(2275943), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ALG11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZFYVE28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8513-01AALG11chr13

52586598

+ZFYVE28chr4

2275943

-
ChimerDB4LUADTCGA-55-8513-01AALG11chr13

52586598

+ZFYVE28chr4

2275943

-


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Fusion Gene ORF analysis for ALG11-ZFYVE28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000523764ENST00000290974ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
In-frameENST00000523764ENST00000511071ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
In-frameENST00000523764ENST00000515312ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000523764ENST00000515169ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000523764ENST00000509171ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000523764ENST00000503000ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-5UTRENST00000523764ENST00000508471ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000523764ENST00000505421ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
In-frameENST00000521508ENST00000290974ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
In-frameENST00000521508ENST00000511071ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
In-frameENST00000521508ENST00000515312ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000521508ENST00000515169ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000521508ENST00000509171ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000521508ENST00000503000ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-5UTRENST00000521508ENST00000508471ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
5CDS-intronENST00000521508ENST00000505421ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-3CDSENST00000519151ENST00000290974ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-3CDSENST00000519151ENST00000511071ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-3CDSENST00000519151ENST00000515312ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-intronENST00000519151ENST00000515169ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-intronENST00000519151ENST00000509171ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-intronENST00000519151ENST00000503000ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-5UTRENST00000519151ENST00000508471ALG11chr13

52586598

+ZFYVE28chr4

2275943

-
intron-intronENST00000519151ENST00000505421ALG11chr13

52586598

+ZFYVE28chr4

2275943

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000523764ALG11chr1352586598+ENST00000290974ZFYVE28chr42275943-18056521677218
ENST00000523764ALG11chr1352586598+ENST00000511071ZFYVE28chr42275943-10646521677218
ENST00000523764ALG11chr1352586598+ENST00000515312ZFYVE28chr42275943-9086521677218
ENST00000521508ALG11chr1352586598+ENST00000290974ZFYVE28chr42275943-1789495661218
ENST00000521508ALG11chr1352586598+ENST00000511071ZFYVE28chr42275943-1048495661218
ENST00000521508ALG11chr1352586598+ENST00000515312ZFYVE28chr42275943-892495661218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000523764ENST00000290974ALG11chr1352586598+ZFYVE28chr42275943-0.0283591750.9716409
ENST00000523764ENST00000511071ALG11chr1352586598+ZFYVE28chr42275943-0.0133470090.98665303
ENST00000523764ENST00000515312ALG11chr1352586598+ZFYVE28chr42275943-0.0073950290.992605
ENST00000521508ENST00000290974ALG11chr1352586598+ZFYVE28chr42275943-0.0339655840.9660344
ENST00000521508ENST00000511071ALG11chr1352586598+ZFYVE28chr42275943-0.0154692010.9845308
ENST00000521508ENST00000515312ALG11chr1352586598+ZFYVE28chr42275943-0.0086686890.99133134

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Fusion Genomic Features for ALG11-ZFYVE28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ALG11-ZFYVE28


check button Go to

FGviewer for the breakpoints of chr13:52586598-chr4:2275943

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALG11

Q2TAA5

.
FUNCTION: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain. {ECO:0000269|PubMed:20080937}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZFYVE28chr13:52586598chr4:2275943ENST00000290974713817_879683.6666666666666888.0Zinc fingerFYVE-type
TgeneZFYVE28chr13:52586598chr4:2275943ENST0000050300007817_8790288.0Zinc fingerFYVE-type
TgeneZFYVE28chr13:52586598chr4:2275943ENST0000050917105817_8790173.0Zinc fingerFYVE-type
TgeneZFYVE28chr13:52586598chr4:2275943ENST00000511071612817_879653.6666666666666858.0Zinc fingerFYVE-type
TgeneZFYVE28chr13:52586598chr4:2275943ENST0000051516907817_8790164.0Zinc fingerFYVE-type
TgeneZFYVE28chr13:52586598chr4:2275943ENST00000515312713817_879613.6666666666666818.0Zinc fingerFYVE-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALG11chr13:52586598chr4:2275943ENST00000521508+1420_4014.666666666666666493.0TransmembraneHelical
HgeneALG11chr13:52586598chr4:2275943ENST00000521508+14234_25414.666666666666666493.0TransmembraneHelical


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Fusion Gene Sequence for ALG11-ZFYVE28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000523764_ENST00000290974_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(transcript)=1805nt_BP=65nt
GAGTTCGGGGGTCGGCGGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCC
TCAGACAAGATGGGGCCAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGC
AGCCACGACCTCATCCACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATT
CTTAAAACACTGTTTGAGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCG
GCCTTGGAGGACTGTGCACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCG
GAGTGGGTGCCAGACGAGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGT
GGGAAGATCTTCTGCTCGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGC
TACATGTTCCATGTCACGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACC
CCCAGGAAGGTGGGGCCACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGC
ATCCAGAGCCTCTGTCCTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCA
GGGGACCCGGAGGAGCCTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCT
GGGGCTATGGGAATCGGGGCGGGTGATGGAGGTGGACAAGAGTGGGGCCACTCTGCGCCTCTGCTGTTGCGGTGAATCTGGAAGCCGGAG
CAAGGGCCACTCCACAGGCTCTTTGGCACAGCAGGGCTCCCTATGTGCCTCCCAAACGTCAAATGCAGGCTACCCATTCTCCCCATCAGC
TGCCCACCTCGTTCCCCAGCCCTCACCCCTCACCCCTCACCATCCTTCCTCAGGACTTGGCTAAACAACATGCATCTCATTTCTTCTTGG
AGTGGGGAGATGCGGGAAGCTGACCCAGTGGTCCTCTAGGCAGGCAGGGTGCTCCTGGTGTCTGCCCACCACTGTCCCCTTGCTGATGGC
ATGGGGGTCCGACCAGGCACTGACACCGCAGGCAGAGGTTGCTCGGGGCCTTGGGTCGGGTTTACCAATCAGCCAGGACGCCCGGGGCCA
CCAGCTCAGCTACCACTTCCCCTTCCCTCTGCACCCTCTGGAACCCTGGCCCAATTCCTCAGACCCCAGAGTGGCCTGGGACCCAAGCTG
CCGCAGCTGAGTGGCCCCAGCGGACACCTCCTCAGGCTTAAATCTCAGGCTTCACATTGCAATGACGATTGCAGTTTTATTTTTGGAGAT
GACACACCTACTGCTTCTTTTCTAGGATAAATCTAATTACTGTTTACTGGTGGAGTACATATGCATAGAAACGGCTTCTGTCGGGGGGAG
AGTATATAATGGAGGAAATATTATGTATTGAGATTATATTTATTTTCTAAATGCTGTAATTTGAAGCCATTTCCATAAATCTATTTAAGG

>In-frame_ENST00000523764_ENST00000290974_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(amino acids)=218AA_start in transcript=21_stop in transcript=677
MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV
MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR

--------------------------------------------------------------
>In-frame_ENST00000523764_ENST00000511071_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(transcript)=1064nt_BP=65nt
GAGTTCGGGGGTCGGCGGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCC
TCAGACAAGATGGGGCCAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGC
AGCCACGACCTCATCCACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATT
CTTAAAACACTGTTTGAGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCG
GCCTTGGAGGACTGTGCACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCG
GAGTGGGTGCCAGACGAGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGT
GGGAAGATCTTCTGCTCGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGC
TACATGTTCCATGTCACGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACC
CCCAGGAAGGTGGGGCCACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGC
ATCCAGAGCCTCTGTCCTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCA
GGGGACCCGGAGGAGCCTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCT

>In-frame_ENST00000523764_ENST00000511071_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(amino acids)=218AA_start in transcript=21_stop in transcript=677
MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV
MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR

--------------------------------------------------------------
>In-frame_ENST00000523764_ENST00000515312_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(transcript)=908nt_BP=65nt
GAGTTCGGGGGTCGGCGGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCC
TCAGACAAGATGGGGCCAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGC
AGCCACGACCTCATCCACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATT
CTTAAAACACTGTTTGAGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCG
GCCTTGGAGGACTGTGCACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCG
GAGTGGGTGCCAGACGAGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGT
GGGAAGATCTTCTGCTCGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGC
TACATGTTCCATGTCACGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACC
CCCAGGAAGGTGGGGCCACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGC
ATCCAGAGCCTCTGTCCTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCA

>In-frame_ENST00000523764_ENST00000515312_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(amino acids)=218AA_start in transcript=21_stop in transcript=677
MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV
MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR

--------------------------------------------------------------
>In-frame_ENST00000521508_ENST00000290974_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(transcript)=1789nt_BP=49nt
GGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGC
CAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCC
ACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTG
AGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTG
CACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACG
AGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCT
CGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCA
CGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGC
CACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTC
CTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCAGGGGACCCGGAGGAGC
CTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCTGGGGCTATGGGAATCG
GGGCGGGTGATGGAGGTGGACAAGAGTGGGGCCACTCTGCGCCTCTGCTGTTGCGGTGAATCTGGAAGCCGGAGCAAGGGCCACTCCACA
GGCTCTTTGGCACAGCAGGGCTCCCTATGTGCCTCCCAAACGTCAAATGCAGGCTACCCATTCTCCCCATCAGCTGCCCACCTCGTTCCC
CAGCCCTCACCCCTCACCCCTCACCATCCTTCCTCAGGACTTGGCTAAACAACATGCATCTCATTTCTTCTTGGAGTGGGGAGATGCGGG
AAGCTGACCCAGTGGTCCTCTAGGCAGGCAGGGTGCTCCTGGTGTCTGCCCACCACTGTCCCCTTGCTGATGGCATGGGGGTCCGACCAG
GCACTGACACCGCAGGCAGAGGTTGCTCGGGGCCTTGGGTCGGGTTTACCAATCAGCCAGGACGCCCGGGGCCACCAGCTCAGCTACCAC
TTCCCCTTCCCTCTGCACCCTCTGGAACCCTGGCCCAATTCCTCAGACCCCAGAGTGGCCTGGGACCCAAGCTGCCGCAGCTGAGTGGCC
CCAGCGGACACCTCCTCAGGCTTAAATCTCAGGCTTCACATTGCAATGACGATTGCAGTTTTATTTTTGGAGATGACACACCTACTGCTT
CTTTTCTAGGATAAATCTAATTACTGTTTACTGGTGGAGTACATATGCATAGAAACGGCTTCTGTCGGGGGGAGAGTATATAATGGAGGA

>In-frame_ENST00000521508_ENST00000290974_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(amino acids)=218AA_start in transcript=5_stop in transcript=661
MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV
MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR

--------------------------------------------------------------
>In-frame_ENST00000521508_ENST00000511071_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(transcript)=1048nt_BP=49nt
GGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGC
CAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCC
ACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTG
AGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTG
CACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACG
AGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCT
CGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCA
CGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGC
CACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTC
CTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCAGGGGACCCGGAGGAGC
CTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCTGGGGCTATGGGAATCG

>In-frame_ENST00000521508_ENST00000511071_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(amino acids)=218AA_start in transcript=5_stop in transcript=661
MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV
MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR

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>In-frame_ENST00000521508_ENST00000515312_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(transcript)=892nt_BP=49nt
GGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGC
CAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCC
ACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTG
AGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTG
CACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACG
AGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCT
CGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCA
CGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGC
CACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTC

>In-frame_ENST00000521508_ENST00000515312_TCGA-55-8513-01A_ALG11_chr13_52586598_+_ZFYVE28_chr4_2275943_length(amino acids)=218AA_start in transcript=5_stop in transcript=661
MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV
MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR

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Fusion Gene PPI Analysis for ALG11-ZFYVE28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALG11-ZFYVE28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALG11-ZFYVE28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALG11C3150913CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ip3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT