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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNN3-LAPTM4B (FusionGDB2 ID:41338)

Fusion Gene Summary for KCNN3-LAPTM4B

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNN3-LAPTM4B
Fusion gene ID: 41338
HgeneTgene
Gene symbol

KCNN3

LAPTM4B

Gene ID

3782

55353

Gene namepotassium calcium-activated channel subfamily N member 3lysosomal protein transmembrane 4 beta
SynonymsKCa2.3|SK3|SKCA3|ZLS3|hSK3LAPTM4beta|LC27
Cytomap

1q21.3

8q22.1

Type of geneprotein-codingprotein-coding
Descriptionsmall conductance calcium-activated potassium channel protein 3SKCa 3potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3potassium intermediate/small conductance calcium-activated channel, subfamily N, member lysosomal-associated transmembrane protein 4Blysosomal associated protein transmembrane 4 betalysosome-associated transmembrane protein 4-beta
Modification date2020032920200313
UniProtAcc

Q9UGI6

Q86VI4

Ensembl transtripts involved in fusion geneENST00000271915, ENST00000361147, 
ENST00000358505, ENST00000515643, 
ENST00000445593, ENST00000521545, 
Fusion gene scores* DoF score6 X 6 X 5=18014 X 8 X 8=896
# samples 816
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/896*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNN3 [Title/Abstract] AND LAPTM4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNN3(154794565)-LAPTM4B(98817581), # samples:1
Anticipated loss of major functional domain due to fusion event.KCNN3-LAPTM4B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLAPTM4B

GO:0032509

endosome transport via multivesicular body sorting pathway

25588945

TgeneLAPTM4B

GO:0032911

negative regulation of transforming growth factor beta1 production

26126825


check buttonFusion gene breakpoints across KCNN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LAPTM4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4449-01AKCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+


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Fusion Gene ORF analysis for KCNN3-LAPTM4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000271915ENST00000445593KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
In-frameENST00000271915ENST00000521545KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
In-frameENST00000361147ENST00000445593KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
In-frameENST00000361147ENST00000521545KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
Frame-shiftENST00000358505ENST00000445593KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
Frame-shiftENST00000358505ENST00000521545KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
intron-3CDSENST00000515643ENST00000445593KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+
intron-3CDSENST00000515643ENST00000521545KCNN3chr1

154794565

-LAPTM4Bchr8

98817581

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000271915KCNN3chr1154794565-ENST00000445593LAPTM4Bchr898817581+34661345581926622
ENST00000271915KCNN3chr1154794565-ENST00000521545LAPTM4Bchr898817581+19271345581926623
ENST00000361147KCNN3chr1154794565-ENST00000445593LAPTM4Bchr898817581+2366245131826231
ENST00000361147KCNN3chr1154794565-ENST00000521545LAPTM4Bchr898817581+827245131826232

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000271915ENST00000445593KCNN3chr1154794565-LAPTM4Bchr898817581+0.0091465080.9908535
ENST00000271915ENST00000521545KCNN3chr1154794565-LAPTM4Bchr898817581+0.039073870.9609261
ENST00000361147ENST00000445593KCNN3chr1154794565-LAPTM4Bchr898817581+0.0003999520.9996001
ENST00000361147ENST00000521545KCNN3chr1154794565-LAPTM4Bchr898817581+0.0005186490.9994814

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Fusion Genomic Features for KCNN3-LAPTM4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KCNN3chr1154794564-LAPTM4Bchr898817580+1.53E-091
KCNN3chr1154794564-LAPTM4Bchr898817580+1.53E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNN3-LAPTM4B


check button Go to

FGviewer for the breakpoints of chr1:154794565-chr8:98817581

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KCNN3

Q9UGI6

LAPTM4B

Q86VI4

FUNCTION: Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:31155282). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. {ECO:0000269|PubMed:31155282}.FUNCTION: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:25588945, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:26126825, ECO:0000269|PubMed:26280656}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000044559307163_183124.0318.0TransmembraneHelical
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000044559307191_211124.0318.0TransmembraneHelical
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000044559307244_264124.0318.0TransmembraneHelical
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000052154507117_13733.0227.0TransmembraneHelical
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000052154507163_18333.0227.0TransmembraneHelical
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000052154507191_21133.0227.0TransmembraneHelical
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000052154507244_26433.0227.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-2830_9430.0419.0Compositional biasNote=Gln-rich
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-2842_6430.0419.0Compositional biasNote=Pro-rich
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28683_68730.0419.0Compositional biasNote=Poly-Gln
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28727_73030.0419.0Compositional biasNote=Poly-Ser
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-2830_9438.0427.0Compositional biasNote=Gln-rich
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-2842_6438.0427.0Compositional biasNote=Pro-rich
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28683_68738.0427.0Compositional biasNote=Poly-Gln
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28727_73038.0427.0Compositional biasNote=Poly-Ser
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28494_51430.0419.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28494_51438.0427.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28561_63730.0419.0RegionCalmodulin-binding
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28561_63738.0427.0RegionCalmodulin-binding
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28288_30830.0419.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28315_33530.0419.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28366_38630.0419.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28405_42530.0419.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28454_47430.0419.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN3chr1:154794565chr8:98817581ENST00000358505-28523_54330.0419.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28288_30838.0427.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28315_33538.0427.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28366_38638.0427.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28405_42538.0427.0TransmembraneHelical%3B Name%3DSegment S4
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28454_47438.0427.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNN3chr1:154794565chr8:98817581ENST00000361147-28523_54338.0427.0TransmembraneHelical%3B Name%3DSegment S6
TgeneLAPTM4Bchr1:154794565chr8:98817581ENST0000044559307117_137124.0318.0TransmembraneHelical


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Fusion Gene Sequence for KCNN3-LAPTM4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000271915_ENST00000445593_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(transcript)=3466nt_BP=1345nt
TTGAGCCAGCGAGGAGTGAAGCTGAGCCTGGCCTCACACGCTCCTAGAGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCT
CCAAGCTCCCCTCCTGCTCTCCCTCCCTGCCCAATACAATGCATTCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAA
GCAAGCCAAAGAGAGGACTGGAGCCAAGATACTGGTGGGGGAGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGC
TTTGGGGTGGGGGCTTGTGCTGCAGGGAATACAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTT
GGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTGGGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCC
AGCGCCACCAGCAGCCCCCCAGCAGCCCCTGGGACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCC
CACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCA
CTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCG
GGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCG
GAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGA
GGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCTT
CCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGA
CTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGACTCCATGTT
TTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGATCAT
CAATGCTGTGGTACTGTTGATTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGACTTTGA
GTTCATGGATGATGCCAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAA
GCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTA
TCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGT
CCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGG
TAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGC
TGCCAAGGAGCCACCGCCACCTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTGAGGGCAGCAGCTTGACTTTGCAGACATCTGAG
CAATAGTTCTGTTATTTCACTTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCTGAAATGCTACTTTTTAAAATTTAGATGTTAGATTG
AAAACTGTAGTTTTCAACATATGCTTTGCTGGAACACTGTGATAGATTAACTGTAGAATTCTTCCTGTACGATTGGGGATATAATGGGCT
TCACTAACCTTCCCTAGGCATTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAAGTTGGGCA
TTTTTCTCTCTGTTCCCTCTCTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACTTTTTCTTCAGCCATTCCAGCATAGAGAACAAA
ACCTTATGGAAACAGGAATGTCAATTGTGTAATCATTGTTCTAATTAGGTAAATAGAAGTCCTTATGTATGTGTTACAAGAATTTCCCCC
ACAACATCCTTTATGACTGAAGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAAGC
ACCAGGCCGTGGGAGCAGTGACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGGGACATGGGGTGACATGCCTCGTATGTGTTAGA
GGGTGGAATGGATGTGTTTGGCGCTGCATGGGATCTGGTGCCCCTCTTCTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTTACTAAG
TGTTCTGCCCTAGATTGGTTCAAGGAGGTCATCCAACTGACTTTATCAAGTGGAATTGGGATATATTTGATATACTTCTGCCTAACAACA
TGGAAAAGGGTTTTCTTTTCCCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAACATTTT
CAGAAAAATGAGGATTGCCTTCCTTGTATGCGCTTTTTACCTTGACTACCTGAATTGCAAGGGATTTTTATATATTCATATGTTACAAAG
TCAGCAACTCTCCTGTTGGTTCATTATTGAATGTGCTGTAAATTAAGTTGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAGATGACC
TTGTGATTTTGTGCTGATTGTGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGATGCACCCAGTTCAGCCTAAGGAGTAGGCTTTT
TTTTGGGGGGGGGAGGTCGGGTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGTTAAAATATTGAAATGTTTAAGTGGATAACTAT
ATTATTCATAAAATGACTGAGTGAAAACTAATACACTATGAGATGAAAAGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGTAATTAC
TATGAAATAACAATTTCTAGAAATGAAGAACAATCCGTGGAGAATAAATTACCATTGGTGTGGGGGAAAAAAGCCAAACAGAAGTAGAAA

>In-frame_ENST00000271915_ENST00000445593_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(amino acids)=622AA_start in transcript=58_stop in transcript=1926
MREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTS
GHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQ
PVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGV
MKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRR
ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQIINAVVLLILLSALADPDQYN
FSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRD

--------------------------------------------------------------
>In-frame_ENST00000271915_ENST00000521545_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(transcript)=1927nt_BP=1345nt
TTGAGCCAGCGAGGAGTGAAGCTGAGCCTGGCCTCACACGCTCCTAGAGGACCACCTCCTGAGAGAGTTCTTTCACCCCCTCTTCTTTCT
CCAAGCTCCCCTCCTGCTCTCCCTCCCTGCCCAATACAATGCATTCTTGAGTGGCAGCGTCTGGACTCCAGGCAGCCCCAGAGAACCGAA
GCAAGCCAAAGAGAGGACTGGAGCCAAGATACTGGTGGGGGAGATTGGATGCCTGGCTTTCTTTGAGGACATCTTTGGAGCGAGGGTGGC
TTTGGGGTGGGGGCTTGTGCTGCAGGGAATACAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCATGACTCGGGGGTGGGGGACTT
GGATGAAGACCCCAAGTGCCCCTGTCCATCCTCTGGGGATGAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCCACCACCGCC
AGCGCCACCAGCAGCCCCCCAGCAGCCCCTGGGACCCTCGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAGCAGCCACCGCATCCCCTGTCTCAGCTCGCCCAACTCCAGAGCCAGCCCGTCCACCCTGGCCTGCTGCACTCCTCTCC
CACCGCTTTCAGGGCCCCCCCTTCGTCCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTCAATCTCAATGACCA
CTTGCTTGGCCACTCTCCAAGTTCCACAGCTACAAGTGGGCCTGGCGGAGGCAGCCGGCACCGACAGGCCAGCCCCCTGGTGCACCGGCG
GGACAGCAACCCCTTCACGGAGATCGCCATGAGCTCCTGCAAGTATAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCCCG
GAGGAACCTCATCGAGGCCGAGACTGAGGGCCAACCCCTCCAGCTTTTCAGCCCTAGCAACCCCCCGGAGATCGTCATCTCCTCCCGGGA
GGACAACCATGCCCACCAGACCCTGCTCCATCACCCTAATGCCACCCACAACCACCAGCATGCCGGCACCACCGCCAGCAGCACCACCTT
CCCCAAAGCCAACAAGCGGAAAAACCAAAACATTGGCTATAAGCTGGGACACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGTGA
CTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAGCTCTCTTGGGGTTTGTACTCAAAGGACTCCATGTT
TTCGTTGGCCCTGAAATGCCTTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGATCAT
CAATGCTGTGGTACTGTTGATTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGACTTTGA
GTTCATGGATGATGCCAACATGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAA
GCAACGCGCAGCCTGGATCATCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTA
TCCAAACTCCATTCAGGAATACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGT
CCTTATTATTCTTCTGTTTATTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGG
TAGGAACTCCTCTGATGTCCTGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGC

>In-frame_ENST00000271915_ENST00000521545_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(amino acids)=623AA_start in transcript=58_stop in transcript=1926
MREFFHPLFFLQAPLLLSLPAQYNAFLSGSVWTPGSPREPKQAKERTGAKILVGEIGCLAFFEDIFGARVALGWGLVLQGIQPGPKMDTS
GHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQ
PVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGV
MKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRR
ALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQIINAVVLLILLSALADPDQYN
FSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRD

--------------------------------------------------------------
>In-frame_ENST00000361147_ENST00000445593_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(transcript)=2366nt_BP=245nt
CAGGAAAGTCAGCTTAAAGGACACTCCTTGCAGGGACTGAGCTGGCACCTACTCCTTAGAGCTTGCTGATACCAGGCCTGCCACGCGACA
TCTGCAAGGACAGTTGTTTGGTGTTTTGCTTCAGGTTATAGATGGAGAGACCTATAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCC
TTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGATCATCAATGCTGTGGTACTGTTGA
TTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGACTTTGAGTTCATGGATGATGCCAACA
TGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCA
TCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAAT
ACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTA
TTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCC
TGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCAC
CTTACGTGTCTGCCTAAGCCTTCAAGTGGGCGGAGCTGAGGGCAGCAGCTTGACTTTGCAGACATCTGAGCAATAGTTCTGTTATTTCAC
TTTTGCCATGAGCCTCTCTGAGCTTGTTTGTTGCTGAAATGCTACTTTTTAAAATTTAGATGTTAGATTGAAAACTGTAGTTTTCAACAT
ATGCTTTGCTGGAACACTGTGATAGATTAACTGTAGAATTCTTCCTGTACGATTGGGGATATAATGGGCTTCACTAACCTTCCCTAGGCA
TTGAAACTTCCCCCAAATCTGATGGACCTAGAAGTCTGCTTTTGTACCTGCTGGGCCCCAAAGTTGGGCATTTTTCTCTCTGTTCCCTCT
CTTTTGAAAATGTAAAATAAAACCAAAAATAGACAACTTTTTCTTCAGCCATTCCAGCATAGAGAACAAAACCTTATGGAAACAGGAATG
TCAATTGTGTAATCATTGTTCTAATTAGGTAAATAGAAGTCCTTATGTATGTGTTACAAGAATTTCCCCCACAACATCCTTTATGACTGA
AGTTCAATGACAGTTTGTGTTTGGTGGTAAAGGATTTTCTCCATGGCCTGAATTAAGACCATTAGAAAGCACCAGGCCGTGGGAGCAGTG
ACCATCTGCTGACTGTTCTTGTGGATCTTGTGTCCAGGGACATGGGGTGACATGCCTCGTATGTGTTAGAGGGTGGAATGGATGTGTTTG
GCGCTGCATGGGATCTGGTGCCCCTCTTCTCCTGGATTCACATCCCCACCCAGGGCCCGCTTTTACTAAGTGTTCTGCCCTAGATTGGTT
CAAGGAGGTCATCCAACTGACTTTATCAAGTGGAATTGGGATATATTTGATATACTTCTGCCTAACAACATGGAAAAGGGTTTTCTTTTC
CCTGCAAGCTACATCCTACTGCTTTGAACTTCCAAGTATGTCTAGTCACCTTTTAAAATGTAAACATTTTCAGAAAAATGAGGATTGCCT
TCCTTGTATGCGCTTTTTACCTTGACTACCTGAATTGCAAGGGATTTTTATATATTCATATGTTACAAAGTCAGCAACTCTCCTGTTGGT
TCATTATTGAATGTGCTGTAAATTAAGTTGTTTGCAATTAAAACAAGGTTTGCCCACATCCAAGATGACCTTGTGATTTTGTGCTGATTG
TGTCTGAGGACCTTTCCCTCCACATATGGTCTGGCAGATGCACCCAGTTCAGCCTAAGGAGTAGGCTTTTTTTTGGGGGGGGGAGGTCGG
GTGGGGGGGATTTTTAATCTTTTAATTTTCAAGATGGTTAAAATATTGAAATGTTTAAGTGGATAACTATATTATTCATAAAATGACTGA
GTGAAAACTAATACACTATGAGATGAAAAGTACTTGTCAGGGATTTTCAAGCTTTTGCTCAAGTAATTACTATGAAATAACAATTTCTAG
AAATGAAGAACAATCCGTGGAGAATAAATTACCATTGGTGTGGGGGAAAAAAGCCAAACAGAAGTAGAAAAAGGTGTAGCCGGCATACAA

>In-frame_ENST00000361147_ENST00000445593_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(amino acids)=231AA_start in transcript=131_stop in transcript=826
MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILI
CAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISC

--------------------------------------------------------------
>In-frame_ENST00000361147_ENST00000521545_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(transcript)=827nt_BP=245nt
CAGGAAAGTCAGCTTAAAGGACACTCCTTGCAGGGACTGAGCTGGCACCTACTCCTTAGAGCTTGCTGATACCAGGCCTGCCACGCGACA
TCTGCAAGGACAGTTGTTTGGTGTTTTGCTTCAGGTTATAGATGGAGAGACCTATAAAGGACTCCATGTTTTCGTTGGCCCTGAAATGCC
TTATCAGTCTGTCCACCATCATCCTTTTGGGCTTGATCATCGCCTACCACACACGTGAAGTCCAGATCATCAATGCTGTGGTACTGTTGA
TTTTATTGAGTGCCCTGGCTGATCCGGATCAGTATAACTTTTCAAGTTCTGAACTGGGAGGTGACTTTGAGTTCATGGATGATGCCAACA
TGTGCATTGCCATTGCGATTTCTCTTCTCATGATCCTGATATGTGCTATGGCTACTTACGGAGCGTACAAGCAACGCGCAGCCTGGATCA
TCCCATTCTTCTGTTACCAGATCTTTGACTTTGCCCTGAACATGTTGGTTGCAATCACTGTGCTTATTTATCCAAACTCCATTCAGGAAT
ACATACGGCAACTGCCTCCTAATTTTCCCTACAGAGATGATGTCATGTCAGTGAATCCTACCTGTTTGGTCCTTATTATTCTTCTGTTTA
TTAGCATTATCTTGACTTTTAAGGGTTACTTGATTAGCTGTGTTTGGAACTGCTACCGATACATCAATGGTAGGAACTCCTCTGATGTCC
TGGTTTATGTTACCAGCAATGACACTACGGTGCTGCTACCCCCGTATGATGATGCCACTGTGAATGGTGCTGCCAAGGAGCCACCGCCAC

>In-frame_ENST00000361147_ENST00000521545_TCGA-CG-4449-01A_KCNN3_chr1_154794565_-_LAPTM4B_chr8_98817581_length(amino acids)=232AA_start in transcript=131_stop in transcript=826
MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILI
CAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KCNN3-LAPTM4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNN3-LAPTM4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNN3-LAPTM4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKCNN3C0005586Bipolar Disorder5PSYGENET
HgeneKCNN3C0036341Schizophrenia3PSYGENET
HgeneKCNN3C0004238Atrial Fibrillation2CTD_human
HgeneKCNN3C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneKCNN3C2585653Persistent atrial fibrillation2CTD_human
HgeneKCNN3C3468561familial atrial fibrillation2CTD_human
HgeneKCNN3C0020541Portal Hypertension1GENOMICS_ENGLAND
HgeneKCNN3C0038002Splenomegaly1GENOMICS_ENGLAND
HgeneKCNN3C0042345Varicosity1GENOMICS_ENGLAND
HgeneKCNN3C0796013Zimmerman Laband syndrome1GENOMICS_ENGLAND;ORPHANET