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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNQ3-NDRG1 (FusionGDB2 ID:41375)

Fusion Gene Summary for KCNQ3-NDRG1

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNQ3-NDRG1
Fusion gene ID: 41375
HgeneTgene
Gene symbol

KCNQ3

NDRG1

Gene ID

3786

10397

Gene namepotassium voltage-gated channel subfamily Q member 3N-myc downstream regulated 1
SynonymsBFNC2|EBN2|KV7.3CAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5
Cytomap

8q24.22

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily KQT member 3potassium channel subunit alpha KvLQT3potassium channel, voltage gated KQT-like subfamily Q, member 3potassium channel, voltage-gated, subfamily Q, member 3potassium voltage-gated channel, KQT-likeprotein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein
Modification date2020031320200328
UniProtAcc.

Q92597

Ensembl transtripts involved in fusion geneENST00000388996, ENST00000521134, 
ENST00000519445, 		ENST00000323851, 
ENST00000354944, ENST00000521414, 
ENST00000537882, ENST00000414097, 
ENST00000518176, ENST00000522476, 
ENST00000518066, 
Fusion gene scores* DoF score13 X 10 X 5=65024 X 17 X 10=4080
# samples 1426
** MAII scorelog2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4080*10)=-3.9719856238304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNQ3 [Title/Abstract] AND NDRG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNQ3(133492393)-NDRG1(134276895), # samples:1
KCNQ3(133310284)-NDRG1(134266781), # samples:1
KCNQ3(133310371)-NDRG1(134266781), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNQ3

GO:0071805

potassium ion transmembrane transport

11159685|27564677


check buttonFusion gene breakpoints across KCNQ3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NDRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1023KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
ChimerDB4BRCATCGA-AC-A7VB-01AKCNQ3chr8

133310284

-NDRG1chr8

134266781

+
ChimerDB4BRCATCGA-AC-A7VB-01AKCNQ3chr8

133310371

-NDRG1chr8

134266781

+


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Fusion Gene ORF analysis for KCNQ3-NDRG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000388996ENST00000323851KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000388996ENST00000354944KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000521414KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000537882KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000414097KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000518176KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-5UTRENST00000388996ENST00000522476KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000388996ENST00000518066KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-3CDSENST00000521134ENST00000323851KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-3CDSENST00000521134ENST00000354944KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000521414KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000537882KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000414097KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000518176KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-5UTRENST00000521134ENST00000522476KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000521134ENST00000518066KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000519445ENST00000323851KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
In-frameENST00000519445ENST00000354944KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000521414KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000537882KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000414097KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000518176KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-5UTRENST00000519445ENST00000522476KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
5CDS-intronENST00000519445ENST00000518066KCNQ3chr8

133492393

-NDRG1chr8

134276895

-
intron-intronENST00000388996ENST00000323851KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000354944KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000521414KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000537882KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000414097KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518176KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000522476KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518066KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000323851KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000354944KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000521414KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000537882KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000414097KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518176KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000522476KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518066KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000323851KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000354944KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000521414KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000537882KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000414097KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518176KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000522476KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518066KCNQ3chr8

133310284

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000323851KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000354944KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000521414KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000537882KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000414097KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518176KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000522476KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000388996ENST00000518066KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000323851KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000354944KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000521414KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000537882KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000414097KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518176KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000522476KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000521134ENST00000518066KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000323851KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000354944KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000521414KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000537882KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000414097KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518176KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000522476KCNQ3chr8

133310371

-NDRG1chr8

134266781

+
intron-intronENST00000519445ENST00000518066KCNQ3chr8

133310371

-NDRG1chr8

134266781

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000388996KCNQ3chr8133492393-ENST00000323851NDRG1chr8134276895-36008077801892370
ENST00000388996KCNQ3chr8133492393-ENST00000354944NDRG1chr8134276895-33898077801682300
ENST00000519445KCNQ3chr8133492393-ENST00000323851NDRG1chr8134276895-32254324051517370
ENST00000519445KCNQ3chr8133492393-ENST00000354944NDRG1chr8134276895-30144324051307300

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000388996ENST00000323851KCNQ3chr8133492393-NDRG1chr8134276895-0.0041147260.9958853
ENST00000388996ENST00000354944KCNQ3chr8133492393-NDRG1chr8134276895-0.036607230.9633928
ENST00000519445ENST00000323851KCNQ3chr8133492393-NDRG1chr8134276895-0.0035522630.9964477
ENST00000519445ENST00000354944KCNQ3chr8133492393-NDRG1chr8134276895-0.0335787160.96642125

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Fusion Genomic Features for KCNQ3-NDRG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCNQ3-NDRG1


check button Go to

FGviewer for the breakpoints of chr8:133492393-chr8:134276895

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NDRG1

Q92597

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-11513_24128.66666666666666873.0Compositional biasNote=Poly-Gly
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-1151_121128.66666666666666873.0Topological domainCytoplasmic
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216339_36833.0395.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014339_3680329.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015339_3680314.0RegionNote=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216339_34833.0395.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216349_35833.0395.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000323851216359_36833.0395.0RepeatNote=3
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216339_34833.0395.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216349_35833.0395.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000414097216359_36833.0395.0RepeatNote=3
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014339_3480329.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014349_3580329.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000522476014359_3680329.0RepeatNote=3
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015339_3480314.0RepeatNote=1
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015349_3580314.0RepeatNote=2
TgeneNDRG1chr8:133492393chr8:134276895ENST00000537882015359_3680314.0RepeatNote=3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-11513_240753.0Compositional biasNote=Poly-Gly
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115304_324128.66666666666666873.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115304_3240753.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115316_321128.66666666666666873.0MotifSelectivity filter
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115316_3210753.0MotifSelectivity filter
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115143_152128.66666666666666873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115174_196128.66666666666666873.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115218_225128.66666666666666873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115248_261128.66666666666666873.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115283_303128.66666666666666873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115325_330128.66666666666666873.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115352_872128.66666666666666873.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115143_1520753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115174_1960753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-1151_1210753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115218_2250753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115248_2610753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115283_3030753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115325_3300753.0Topological domainExtracellular
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115352_8720753.0Topological domainCytoplasmic
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115122_142128.66666666666666873.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115153_173128.66666666666666873.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115197_217128.66666666666666873.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115226_247128.66666666666666873.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115262_282128.66666666666666873.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000388996-115331_351128.66666666666666873.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115122_1420753.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115153_1730753.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115197_2170753.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115226_2470753.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115262_2820753.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ3chr8:133492393chr8:134276895ENST00000521134-115331_3510753.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Gene Sequence for KCNQ3-NDRG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000388996_ENST00000323851_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(transcript)=3600nt_BP=807nt
GGCTGGCACCGGGCTTGTAAATAAACTGCGATGCTGTCTTGGGCTCGCCGGCCTGGGTGCCGCCGCCGCCGCCGCCGCCCCGGAGCGCCG
GTTCCAGGCTCCCGCCGCCGCGCGCCCTAGCGCCTCCGCGCCAGCCTCGCGCGCCCTCCCAGCTTCTCCGCAGCCCCCGGCCCGCGACCC
TCGGGGTCCTGCGGCTGACCCGCGCGGGATGTGACCCCCTGACCCCCTGCCTGGCCTCCCCTGCCCCCCAGGGGGCCCGCCTTTGCCTGC
TTTTGGGGGGGGGTGGGGAGGGGCGCGCGGATCATGGCATTGGAGTTCCCGGGCTTGCAGCCGCCGCCGCCGCCTCGTTCACGCACCCCG
AGCGCCCCTTCTTCCCAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGG
GGCGGCTGGCGGCGGCGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGA
GCGGAAAGTGGGGCTGGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGA
GGGCGGCGGCCGCGACGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAA
CAACGCCAAGTACCGGCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAG
CAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGAC
ATCGGCATGAACCACAAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCACGTG
GACGCCCCTGGCCAGCAGGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCCTGGA
GTCCTTCAACAGTTTGGGCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCT
GAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACC
CAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCAC
ATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCG
GGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCA
AAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCC
TTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTC
ACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCG
CACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGC
TAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATAC
TGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCC
AAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCC
TCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCC
TGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACA
AAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGAT
TCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTT
TGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAA
AAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCT
GATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGC
TGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCC
TTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTT
TTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCT
CTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTT
CCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCA
GGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAA
GTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACT
CGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGG
AAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGATATTTGTATTTATTTCCAGACCAATAAATTTGTAACTTTGCAGCGG

>In-frame_ENST00000388996_ENST00000323851_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(amino acids)=370AA_start in transcript=780_stop in transcript=1892
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPS
MDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSN
VEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQ
ISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNS

--------------------------------------------------------------
>In-frame_ENST00000388996_ENST00000354944_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(transcript)=3389nt_BP=807nt
GGCTGGCACCGGGCTTGTAAATAAACTGCGATGCTGTCTTGGGCTCGCCGGCCTGGGTGCCGCCGCCGCCGCCGCCGCCCCGGAGCGCCG
GTTCCAGGCTCCCGCCGCCGCGCGCCCTAGCGCCTCCGCGCCAGCCTCGCGCGCCCTCCCAGCTTCTCCGCAGCCCCCGGCCCGCGACCC
TCGGGGTCCTGCGGCTGACCCGCGCGGGATGTGACCCCCTGACCCCCTGCCTGGCCTCCCCTGCCCCCCAGGGGGCCCGCCTTTGCCTGC
TTTTGGGGGGGGGTGGGGAGGGGCGCGCGGATCATGGCATTGGAGTTCCCGGGCTTGCAGCCGCCGCCGCCGCCTCGTTCACGCACCCCG
AGCGCCCCTTCTTCCCAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGG
GGCGGCTGGCGGCGGCGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGA
GCGGAAAGTGGGGCTGGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGA
GGGCGGCGGCCGCGACGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAA
CAACGCCAAGTACCGGCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAG
CAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGAC
ATCGGCATGAACCACAAAACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAAC
GTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTCCCAC
CTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAACCTG
CACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTGCCCT
GCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCTCCTC
AAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATAC
ATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTCC
CACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGACATC
ACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGGA
CTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAAGCTT
ATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAAG
GAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTGCCAA
AAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGCC
AGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGGGGTA
ATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGAACAA
CAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTTT
CTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATCATGG
TTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTGTTCA
GGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAGG
GGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTTG
TGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAACGTG
AACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCACGTG
GGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCCC
TAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTTTTCA
TTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTCTGGG
ACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGCC
TTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGGA

>In-frame_ENST00000388996_ENST00000354944_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(amino acids)=300AA_start in transcript=780_stop in transcript=1682
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWT
QALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNS
KLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRS

--------------------------------------------------------------
>In-frame_ENST00000519445_ENST00000323851_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(transcript)=3225nt_BP=432nt
CAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGGGGCGGCTGGCGGCGG
CGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGAGCGGAAAGTGGGGCT
GGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGAGGGCGGCGGCCGCGA
CGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAACAACGCCAAGTACCG
GCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAGCAGGACATCGAGACT
TTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCATGAACCAC
AAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAGGAGATCACCCAGCACTTTGCCGTCTGCCACGTGGACGCCCCTGGCCAG
CAGGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATCAGCTGGCTGAAATGCTTCCTGGAGTCCTTCAACAGTTT
GGGCTGAAAAGCATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGC
CTTGTCCTTATCAACGTGAACCCTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGAC
ATGGTGGTGTCCCACCTTTTTGGGAAGGAAGAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATG
AACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTC
ACCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACA
AAGACCACTCTCCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTG
CAGGGCATGGGATACATGCCCTCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGC
ACCCGCAGCCGCTCCCACACCAGCGAGGGCACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGG
GCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCA
GCTGCCGCCCCCGGACTCTGATCTCTGTAGTGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGT
ATTAATCCAAAGCTTATTTTGTAAGAGTGAGCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCG
GTGGACCAAAGGAAGGAAGCAAGCATCTCCGCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAG
ACACCAAACTGCCAAAAACAAGACGCGTAGCAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTG
CCTGGTCAGAAGGCCAGCCGCCCACTTCCCGTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCAT
TTGGGGAGGGGGGTAATAGTGACATGCAGGCACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAG
AGGCATTTGGAACAACAAATCTACGTAGTTAACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAA
ACAAGCTTGATTTTTCTAGCATCCTCTTAATGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAA
CGTTGGGCATCATGGTTTTTGAAGGCTTTAGTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGT
GATTATTCTTGTTCAGGGAGAAGATCATTTAGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGAT
GAGTGTCCTTGCAGGGGCCGGAGTAGGAGCACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGA
GATCCAGTGCAGTTGTGATTTCTGTGGATCCCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAG
CTGGGCTGGAACGTGAACTCAGTAGCTGAACCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGG
GTGGGAACTCACGTGGGGAGCGGTGGCTGAGAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCC
TCTTTTCCTGCTCCCTAACCTTTCGCCGAATGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACT
GCCTTGTACTTTTCATTTTGGCTCACCGTGGATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGAC
CCGAGGATTTCTGGGACCCCGCAGTTGGGAGGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCC
ATCACCTTGGAGGCCTTCCCTGGCCTTGAGTAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACA

>In-frame_ENST00000519445_ENST00000323851_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(amino acids)=370AA_start in transcript=405_stop in transcript=1517
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPS
MDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSN
VEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQ
ISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNS

--------------------------------------------------------------
>In-frame_ENST00000519445_ENST00000354944_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(transcript)=3014nt_BP=432nt
CAGAGCAGCAGCGGAGAAGGCGAAGCGGCCGGCGGGGGCGAGGCAGATGGGGCTCAAGGCGCGCAGGGCGGCGGGGGCGGCTGGCGGCGG
CGGCGACGGGGGCGGCGGAGGCGGCGGGGCGGCTAACCCAGCCGGAGGGGACGCGGCGGCGGCCGGCGACGAGGAGCGGAAAGTGGGGCT
GGCGCCCGGCGACGTGGAGCAAGTCACCTTGGCGCTCGGGGCCGGAGCCGACAAAGACGGGACCCTGCTGCTGGAGGGCGGCGGCCGCGA
CGAGGGGCAGCGGAGGACCCCGCAGGGCATCGGGCTCCTGGCCAAGACCCCGCTGAGCCGCCCAGTCAAGAGAAACAACGCCAAGTACCG
GCGCATCCAAACTTTGATCTACGACGCCCTGGAGAGACCGCGGGGCTGGGCGCTGCTTTACCACGCGTTGGTGAGCAGGACATCGAGACT
TTACATGGCTCTGTTCACGTCACGCTGTGTGGGACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCATGAACCAC
AAAACCTGCGCCTACATCCTAACTCGATTTGCTCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACCCTTGTGCG
GAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGGACCCAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAA
GAAATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGAATGACATGAACCCCGGCAACCTGCACCTGTTCATCAAT
GCCTACAACAGCCGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCACCCTGCAGTGCCCTGCTCTGTTGGTGGTT
GGGGACAGCTCGCCTGCAGTGGATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCTCCTCAAGATGGCGGACTGT
GGCGGCCTCCCGCAGATCTCCCAGCCGGCCAAGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCCTCGGCTAGC
ATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAGCGTCACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGC
ACCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACCAGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGT
GCTGCTGGGAACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGCTAGGCGGCCTGCCCAGCTGCCGCCCCCGGACTCTGATCTCTGTAG
TGGCCCCCTCCTCCCCGGCCCCTTTTCGCCCCCTGCCTGCCATACTGCGCCTAACTCGGTATTAATCCAAAGCTTATTTTGTAAGAGTGA
GCTCTGGTGGAGACAAATGAGGTCTATTACGTGGGTGCCCTCTCCAAAGGCGGGGTGGCGGTGGACCAAAGGAAGGAAGCAAGCATCTCC
GCATCGCATCCTCTTCCATTAACCAGTGGCCGGTTGCCACTCTCCTCCCCTCCCTCAGAGACACCAAACTGCCAAAAACAAGACGCGTAG
CAGCACACACTTCACAAAGCCAAGCCTAGGCCGCCCTGAGCATCCTGGTTCAAACGGGTGCCTGGTCAGAAGGCCAGCCGCCCACTTCCC
GTTTCCTCTTTAACTGAGGAGAAGCTGATCCAGTTTCCGGAAACAAAATCCTTTTCTCATTTGGGGAGGGGGGTAATAGTGACATGCAGG
CACCTCTTTTAAACAGGCAAAACAGGAAGGGGGAAAAGGTGGGATTCATGTCGAGGCTAGAGGCATTTGGAACAACAAATCTACGTAGTT
AACTTGAAGAAACCGATTTTTAAAGTTGGTGCATCTAGAAAGCTTTGAATGCAGAAGCAAACAAGCTTGATTTTTCTAGCATCCTCTTAA
TGTGCAGCAAAAGCAGGCGACAAAATCTCCTGGCTTTACAGACAAAAATATTTCAGCAAACGTTGGGCATCATGGTTTTTGAAGGCTTTA
GTTCTGCTTTCTGCCTCTCCTCCACAGCCCCAACCTCCCACCCCTGATACATGAGCCAGTGATTATTCTTGTTCAGGGAGAAGATCATTT
AGATTTGTTTTGCATTCCTTAGAATGGAGGGCAACATTCCACAGCTGCCCTGGCTGTGATGAGTGTCCTTGCAGGGGCCGGAGTAGGAGC
ACTGGGGTGGGGGTGGAATTGGGGTTACTCGATGTAAGGGATTCCTTGTTGTTGTGTTGAGATCCAGTGCAGTTGTGATTTCTGTGGATC
CCAGCTTGGTTCCAGGAATTTTGTGTGATTGGCTTAAATCCAGTTTTCAATCTTCGACAGCTGGGCTGGAACGTGAACTCAGTAGCTGAA
CCTGTCTGACCCGGTCACGTTCTTGGATCCTCAGAACTCTTTGCTCTTGTCGGGGTGGGGGTGGGAACTCACGTGGGGAGCGGTGGCTGA
GAAAATGTAAGGATTCTGGAATACATATTCCATGGGACTTTCCTTCCCTCTCCTGCTTCCTCTTTTCCTGCTCCCTAACCTTTCGCCGAA
TGGGGCAGCACCACTGACGTTTCTGGGCGGCCAGTGCGGCTGCCAGGTTCCTGTACTACTGCCTTGTACTTTTCATTTTGGCTCACCGTG
GATTTTCTCATAGGAAGTTTGGTCAGAGTGAATTGAATATTGTAAGTCAGCCACTGGGACCCGAGGATTTCTGGGACCCCGCAGTTGGGA
GGAGGAAGTAGTCCAGCCTTCCAGGTGGCGTGAGAGGCAATGACTCGTTACCTGCCGCCCATCACCTTGGAGGCCTTCCCTGGCCTTGAG
TAGAAAAGTCGGGGATCGGGGCAAGAGAGGCTGAGTACGGATGGGAAACTATTGTGCACAAGTCTTTCCAGAGGAGTTTCTTAATGAGAT

>In-frame_ENST00000519445_ENST00000354944_TCGA-23-1023_KCNQ3_chr8_133492393_-_NDRG1_chr8_134276895_length(amino acids)=300AA_start in transcript=405_stop in transcript=1307
MGAALPRVGEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWT
QALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNS
KLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRS

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Fusion Gene PPI Analysis for KCNQ3-NDRG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNQ3-NDRG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCNQ3-NDRG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKCNQ3C1852581EPILEPSY, BENIGN NEONATAL, 25CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneKCNQ3C0220669Familial benign neonatal epilepsy2ORPHANET
HgeneKCNQ3C0005586Bipolar Disorder1PSYGENET
HgeneKCNQ3C0036341Schizophrenia1PSYGENET
HgeneKCNQ3C0270853Juvenile Myoclonic Epilepsy1ORPHANET
TgeneNDRG1C0027627Neoplasm Metastasis2CTD_human
TgeneNDRG1C1832334CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNDRG1C0004114Astrocytoma1CTD_human
TgeneNDRG1C0006142Malignant neoplasm of breast1CTD_human
TgeneNDRG1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneNDRG1C0007134Renal Cell Carcinoma1CTD_human
TgeneNDRG1C0017636Glioblastoma1CTD_human
TgeneNDRG1C0022665Kidney Neoplasm1CTD_human
TgeneNDRG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNDRG1C0023903Liver neoplasms1CTD_human
TgeneNDRG1C0025202melanoma1CTD_human
TgeneNDRG1C0026640Mouth Neoplasms1CTD_human
TgeneNDRG1C0029295Oropharyngeal Neoplasms1CTD_human
TgeneNDRG1C0033578Prostatic Neoplasms1CTD_human
TgeneNDRG1C0149925Small cell carcinoma of lung1CTD_human
TgeneNDRG1C0153381Malignant neoplasm of mouth1CTD_human
TgeneNDRG1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNDRG1C0206658Smooth Muscle Tumor1CTD_human
TgeneNDRG1C0206734Hemangioblastoma1CTD_human
TgeneNDRG1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneNDRG1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNDRG1C0280785Diffuse Astrocytoma1CTD_human
TgeneNDRG1C0334579Anaplastic astrocytoma1CTD_human
TgeneNDRG1C0334580Protoplasmic astrocytoma1CTD_human
TgeneNDRG1C0334581Gemistocytic astrocytoma1CTD_human
TgeneNDRG1C0334582Fibrillary Astrocytoma1CTD_human
TgeneNDRG1C0334583Pilocytic Astrocytoma1CTD_human
TgeneNDRG1C0334588Giant Cell Glioblastoma1CTD_human
TgeneNDRG1C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNDRG1C0345904Malignant neoplasm of liver1CTD_human
TgeneNDRG1C0376358Malignant neoplasm of prostate1CTD_human
TgeneNDRG1C0547065Mixed oligoastrocytoma1CTD_human
TgeneNDRG1C0678222Breast Carcinoma1CTD_human
TgeneNDRG1C0740457Malignant neoplasm of kidney1CTD_human
TgeneNDRG1C0750935Cerebral Astrocytoma1CTD_human
TgeneNDRG1C0750936Intracranial Astrocytoma1CTD_human
TgeneNDRG1C0751692Multiple Hemangioblastomas1CTD_human
TgeneNDRG1C0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneNDRG1C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneNDRG1C1257931Mammary Neoplasms, Human1CTD_human
TgeneNDRG1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneNDRG1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneNDRG1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneNDRG1C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneNDRG1C1458155Mammary Neoplasms1CTD_human
TgeneNDRG1C1621958Glioblastoma Multiforme1CTD_human
TgeneNDRG1C1704230Grade I Astrocytoma1CTD_human
TgeneNDRG1C2349952Oropharyngeal Carcinoma1CTD_human
TgeneNDRG1C4704874Mammary Carcinoma, Human1CTD_human