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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCNQ5-KCNQ5 (FusionGDB2 ID:41387)

Fusion Gene Summary for KCNQ5-KCNQ5

check button Fusion gene summary
Fusion gene informationFusion gene name: KCNQ5-KCNQ5
Fusion gene ID: 41387
HgeneTgene
Gene symbol

KCNQ5

KCNQ5

Gene ID

56479

56479

Gene namepotassium voltage-gated channel subfamily Q member 5potassium voltage-gated channel subfamily Q member 5
SynonymsKv7.5|MRD46Kv7.5|MRD46
Cytomap

6q13

6q13

Type of geneprotein-codingprotein-coding
Descriptionpotassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5
Modification date2020031320200313
UniProtAcc.

Q9NR82

Ensembl transtripts involved in fusion geneENST00000342056, ENST00000355194, 
ENST00000370398, ENST00000370392, 
ENST00000355635, ENST00000414165, 
ENST00000402622, ENST00000403813, 
ENST00000342056, ENST00000355194, 
ENST00000370398, ENST00000370392, 
ENST00000355635, ENST00000414165, 
ENST00000402622, ENST00000403813, 
Fusion gene scores* DoF score8 X 7 X 4=2246 X 6 X 3=108
# samples 86
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCNQ5 [Title/Abstract] AND KCNQ5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCNQ5(73904498)-KCNQ5(73904449), # samples:1
Anticipated loss of major functional domain due to fusion event.KCNQ5-KCNQ5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KCNQ5-KCNQ5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KCNQ5-KCNQ5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
KCNQ5-KCNQ5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKCNQ5

GO:0071805

potassium ion transmembrane transport

10787416|11159685

TgeneKCNQ5

GO:0071805

potassium ion transmembrane transport

10787416|11159685


check buttonFusion gene breakpoints across KCNQ5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KCNQ5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACV342397KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+


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Fusion Gene ORF analysis for KCNQ5-KCNQ5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000342056ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000342056ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000342056ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000342056ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000342056ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000342056ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000342056ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000342056ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000355194ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
In-frameENST00000355194ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000355194ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355194ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355194ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355194ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355194ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355194ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000370398ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000370398ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000370398ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000370398ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000370398ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000370398ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000370398ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000370398ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-3CDSENST00000370392ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-3CDSENST00000370392ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-3CDSENST00000370392ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-intronENST00000370392ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-intronENST00000370392ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-intronENST00000370392ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-intronENST00000370392ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
intron-intronENST00000370392ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000355635ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
In-frameENST00000355635ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000355635ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355635ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355635ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355635ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355635ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000355635ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000414165ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
In-frameENST00000414165ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000414165ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000414165ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000414165ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000414165ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000414165ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000414165ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000402622ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
In-frameENST00000402622ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000402622ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000402622ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000402622ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000402622ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000402622ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000402622ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000403813ENST00000342056KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
In-frameENST00000403813ENST00000355194KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
Frame-shiftENST00000403813ENST00000370398KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000403813ENST00000370392KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000403813ENST00000355635KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000403813ENST00000414165KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000403813ENST00000402622KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+
5CDS-intronENST00000403813ENST00000403813KCNQ5chr6

73904498

-KCNQ5chr6

73904449

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KCNQ5-KCNQ5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KCNQ5-KCNQ5


check button Go to

FGviewer for the breakpoints of chr6:73904498-chr6:73904449

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNQ5

Q9NR82

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209299_3190428.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014299_3190933.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014299_3190.0943.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013299_3190.0924.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012299_3190.0823.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209311_3160428.0MotifSelectivity filter
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014311_3160933.0MotifSelectivity filter
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014311_3160.0943.0MotifSelectivity filter
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013311_3160.0924.0MotifSelectivity filter
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012311_3160.0823.0MotifSelectivity filter
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209147_1560428.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209178_2000428.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392091_1250428.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209222_2290428.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209253_2660428.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209288_2980428.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209320_3250428.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209347_9320428.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014147_1560933.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014178_2000933.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST000003703980141_1250933.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014222_2290933.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014253_2660933.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014288_2980933.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014320_3250933.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014347_9320933.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014147_1560.0943.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014178_2000.0943.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST000004026220141_1250.0943.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014222_2290.0943.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014253_2660.0943.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014288_2980.0943.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014320_3250.0943.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014347_9320.0943.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013147_1560.0924.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013178_2000.0924.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST000004038130131_1250.0924.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013222_2290.0924.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013253_2660.0924.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013288_2980.0924.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013320_3250.0924.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013347_9320.0924.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012147_1560.0823.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012178_2000.0823.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST000004141650121_1250.0823.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012222_2290.0823.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012253_2660.0823.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012288_2980.0823.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012320_3250.0823.0Topological domainExtracellular
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012347_9320.0823.0Topological domainCytoplasmic
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209126_1460428.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209157_1770428.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209201_2210428.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209230_2520428.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209267_2870428.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ5chr6:73904498chr6:73904449ENST0000037039209326_3460428.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014126_1460933.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014157_1770933.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014201_2210933.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014230_2520933.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014267_2870933.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398014326_3460933.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014126_1460.0943.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014157_1770.0943.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014201_2210.0943.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014230_2520.0943.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014267_2870.0943.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622014326_3460.0943.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013126_1460.0924.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013157_1770.0924.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013201_2210.0924.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013230_2520.0924.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013267_2870.0924.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813013326_3460.0924.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012126_1460.0823.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012157_1770.0823.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012201_2210.0823.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012230_2520.0823.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012267_2870.0823.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165012326_3460.0823.0TransmembraneHelical%3B Name%3DSegment S6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19299_3190428.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114299_3190933.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114299_3190.0943.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113299_3190.0924.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112299_3190.0823.0IntramembranePore-forming%3B Name%3DSegment H5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19311_3160428.0MotifSelectivity filter
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114311_3160933.0MotifSelectivity filter
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114311_3160.0943.0MotifSelectivity filter
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113311_3160.0924.0MotifSelectivity filter
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112311_3160.0823.0MotifSelectivity filter
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19147_1560428.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19178_2000428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-191_1250428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19222_2290428.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19253_2660428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19288_2980428.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19320_3250428.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19347_9320428.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114147_1560933.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114178_2000933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-1141_1250933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114222_2290933.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114253_2660933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114288_2980933.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114320_3250933.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114347_9320933.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114147_1560.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114178_2000.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-1141_1250.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114222_2290.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114253_2660.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114288_2980.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114320_3250.0943.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114347_9320.0943.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113147_1560.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113178_2000.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-1131_1250.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113222_2290.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113253_2660.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113288_2980.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113320_3250.0924.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113347_9320.0924.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112147_1560.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112178_2000.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-1121_1250.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112222_2290.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112253_2660.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112288_2980.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112320_3250.0823.0Topological domainExtracellular
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112347_9320.0823.0Topological domainCytoplasmic
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19126_1460428.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19157_1770428.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19201_2210428.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19230_2520428.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19267_2870428.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370392-19326_3460428.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114126_1460933.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114157_1770933.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114201_2210933.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114230_2520933.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114267_2870933.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000370398-114326_3460933.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114126_1460.0943.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114157_1770.0943.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114201_2210.0943.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114230_2520.0943.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114267_2870.0943.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000402622-114326_3460.0943.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113126_1460.0924.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113157_1770.0924.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113201_2210.0924.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113230_2520.0924.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113267_2870.0924.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000403813-113326_3460.0924.0TransmembraneHelical%3B Name%3DSegment S6
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112126_1460.0823.0TransmembraneHelical%3B Name%3DSegment S1
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112157_1770.0823.0TransmembraneHelical%3B Name%3DSegment S2
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112201_2210.0823.0TransmembraneHelical%3B Name%3DSegment S3
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112230_2520.0823.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112267_2870.0823.0TransmembraneHelical%3B Name%3DSegment S5
HgeneKCNQ5chr6:73904498chr6:73904449ENST00000414165-112326_3460.0823.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Gene Sequence for KCNQ5-KCNQ5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for KCNQ5-KCNQ5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCNQ5-KCNQ5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneKCNQ5Q9NR82DB00996GabapentinActivatorSmall moleculeApproved|Investigational
TgeneKCNQ5Q9NR82DB04953EzogabineSmall moleculeApproved|Investigational

Top

Related Diseases for KCNQ5-KCNQ5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKCNQ5C4539851MENTAL RETARDATION, AUTOSOMAL DOMINANT 462GENOMICS_ENGLAND;UNIPROT
HgeneKCNQ5C0027092Myopia1CTD_human
HgeneKCNQ5C0235833Congenital diaphragmatic hernia1CTD_human
HgeneKCNQ5C0265699Congenital hernia of foramen of Morgagni1CTD_human
HgeneKCNQ5C0265700Congenital hernia of foramen of Bochdalek1CTD_human
HgeneKCNQ5C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneKCNQ5C4539851MENTAL RETARDATION, AUTOSOMAL DOMINANT 462GENOMICS_ENGLAND;UNIPROT
TgeneKCNQ5C0027092Myopia1CTD_human
TgeneKCNQ5C0235833Congenital diaphragmatic hernia1CTD_human
TgeneKCNQ5C0265699Congenital hernia of foramen of Morgagni1CTD_human
TgeneKCNQ5C0265700Congenital hernia of foramen of Bochdalek1CTD_human
TgeneKCNQ5C3714756Intellectual Disability1GENOMICS_ENGLAND