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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KCTD5-TSC2 (FusionGDB2 ID:41474)

Fusion Gene Summary for KCTD5-TSC2

check button Fusion gene summary
Fusion gene informationFusion gene name: KCTD5-TSC2
Fusion gene ID: 41474
HgeneTgene
Gene symbol

KCTD5

TSC2

Gene ID

54442

7249

Gene namepotassium channel tetramerization domain containing 5TSC complex subunit 2
Synonyms-LAM|PPP1R160|TSC4
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein KCTD5potassium channel tetramerisation domain containing 5tuberinprotein phosphatase 1, regulatory subunit 160tuberous sclerosis 2 protein
Modification date2020031320200313
UniProtAcc.

TSC22D4

Ensembl transtripts involved in fusion geneENST00000301738, ENST00000564195, 
ENST00000569689, 		ENST00000219476, 
ENST00000382538, ENST00000401874, 
ENST00000353929, ENST00000439673, 
ENST00000350773, ENST00000568454, 
ENST00000568366, 
Fusion gene scores* DoF score4 X 4 X 3=486 X 9 X 4=216
# samples 58
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KCTD5 [Title/Abstract] AND TSC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKCTD5(2747998)-TSC2(2136194), # samples:3
TSC2(2112120)-KCTD5(2732706), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KCTD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TSC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J1-01AKCTD5chr16

2747998

+TSC2chr16

2136194

+
ChimerDB4ACCTCGA-OR-A5J1KCTD5chr16

2747998

+TSC2chr16

2136193

+
ChimerDB4ACCTCGA-OR-A5J1-01AKCTD5chr16

2747998

+TSC2chr16

2136194

+
ChimerDB4ACCTCGA-OR-A5J1-01AKCTD5chr16

2747998

-TSC2chr16

2136194

+


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Fusion Gene ORF analysis for KCTD5-TSC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000301738ENST00000219476KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000382538KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000401874KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000353929KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000439673KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000350773KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000568454KCTD5chr16

2747998

+TSC2chr16

2136194

+
5CDS-intronENST00000301738ENST00000568366KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000219476KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000382538KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000401874KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000353929KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000439673KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000350773KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000564195ENST00000568454KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-intronENST00000564195ENST00000568366KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000219476KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000382538KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000401874KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000353929KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000439673KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000350773KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-3CDSENST00000569689ENST00000568454KCTD5chr16

2747998

+TSC2chr16

2136194

+
intron-intronENST00000569689ENST00000568366KCTD5chr16

2747998

+TSC2chr16

2136194

+
In-frameENST00000301738ENST00000219476KCTD5chr16

2747998

+TSC2chr16

2136193

+
In-frameENST00000301738ENST00000382538KCTD5chr16

2747998

+TSC2chr16

2136193

+
In-frameENST00000301738ENST00000401874KCTD5chr16

2747998

+TSC2chr16

2136193

+
In-frameENST00000301738ENST00000353929KCTD5chr16

2747998

+TSC2chr16

2136193

+
In-frameENST00000301738ENST00000439673KCTD5chr16

2747998

+TSC2chr16

2136193

+
In-frameENST00000301738ENST00000350773KCTD5chr16

2747998

+TSC2chr16

2136193

+
In-frameENST00000301738ENST00000568454KCTD5chr16

2747998

+TSC2chr16

2136193

+
5CDS-intronENST00000301738ENST00000568366KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000219476KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000382538KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000401874KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000353929KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000439673KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000350773KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000564195ENST00000568454KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-intronENST00000564195ENST00000568366KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000219476KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000382538KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000401874KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000353929KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000439673KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000350773KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-3CDSENST00000569689ENST00000568454KCTD5chr16

2747998

+TSC2chr16

2136193

+
intron-intronENST00000569689ENST00000568366KCTD5chr16

2747998

+TSC2chr16

2136193

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000301738KCTD5chr162747998+ENST00000219476TSC2chr162136194+1391527741288404
ENST00000301738KCTD5chr162747998+ENST00000382538TSC2chr162136194+1379527741288404
ENST00000301738KCTD5chr162747998+ENST00000401874TSC2chr162136194+1381527741288404
ENST00000301738KCTD5chr162747998+ENST00000353929TSC2chr162136194+1390527741288404
ENST00000301738KCTD5chr162747998+ENST00000439673TSC2chr162136194+1380527741288404
ENST00000301738KCTD5chr162747998+ENST00000350773TSC2chr162136194+1391527741288404
ENST00000301738KCTD5chr162747998+ENST00000568454TSC2chr162136194+1394527741288404
ENST00000301738KCTD5chr162747998+ENST00000219476TSC2chr162136193+1391527741288404
ENST00000301738KCTD5chr162747998+ENST00000382538TSC2chr162136193+1379527741288404
ENST00000301738KCTD5chr162747998+ENST00000401874TSC2chr162136193+1381527741288404
ENST00000301738KCTD5chr162747998+ENST00000353929TSC2chr162136193+1390527741288404
ENST00000301738KCTD5chr162747998+ENST00000439673TSC2chr162136193+1380527741288404
ENST00000301738KCTD5chr162747998+ENST00000350773TSC2chr162136193+1391527741288404
ENST00000301738KCTD5chr162747998+ENST00000568454TSC2chr162136193+1394527741288404

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301738ENST00000219476KCTD5chr162747998+TSC2chr162136194+0.0074062520.9925937
ENST00000301738ENST00000382538KCTD5chr162747998+TSC2chr162136194+0.0076470070.992353
ENST00000301738ENST00000401874KCTD5chr162747998+TSC2chr162136194+0.0075797010.99242026
ENST00000301738ENST00000353929KCTD5chr162747998+TSC2chr162136194+0.0073821630.9926178
ENST00000301738ENST00000439673KCTD5chr162747998+TSC2chr162136194+0.0074964650.9925035
ENST00000301738ENST00000350773KCTD5chr162747998+TSC2chr162136194+0.0074062520.9925937
ENST00000301738ENST00000568454KCTD5chr162747998+TSC2chr162136194+0.0072927260.9927073
ENST00000301738ENST00000219476KCTD5chr162747998+TSC2chr162136193+0.0074062520.9925937
ENST00000301738ENST00000382538KCTD5chr162747998+TSC2chr162136193+0.0076470070.992353
ENST00000301738ENST00000401874KCTD5chr162747998+TSC2chr162136193+0.0075797010.99242026
ENST00000301738ENST00000353929KCTD5chr162747998+TSC2chr162136193+0.0073821630.9926178
ENST00000301738ENST00000439673KCTD5chr162747998+TSC2chr162136193+0.0074964650.9925035
ENST00000301738ENST00000350773KCTD5chr162747998+TSC2chr162136193+0.0074062520.9925937
ENST00000301738ENST00000568454KCTD5chr162747998+TSC2chr162136193+0.0072927260.9927073

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Fusion Genomic Features for KCTD5-TSC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KCTD5chr162747998+TSC2chr162136193+4.34E-060.9999957
KCTD5chr162747998+TSC2chr162136193+4.34E-060.9999957
KCTD5chr162747998+TSC2chr162136193+4.34E-060.9999957
KCTD5chr162747998+TSC2chr162136193+4.34E-060.9999957

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KCTD5-TSC2


check button Go to

FGviewer for the breakpoints of chr16:2747998-chr16:2136194

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TSC2

TSC22D4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.395

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKCTD5chr16:2747998chr16:2136193ENST00000301738+3644_146151.0235.0DomainNote=BTB
HgeneKCTD5chr16:2747998chr16:2136194ENST00000301738+3644_146151.0235.0DomainNote=BTB
TgeneTSC2chr16:2747998chr16:2136193ENST0000035077334411531_17581531.01785.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136193ENST0000035392934411531_17581511.01765.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136193ENST0000040187433401531_17581487.01741.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136193ENST0000043967332391531_17581451.01705.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136194ENST0000035077334411531_17581531.01785.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136194ENST0000035392934411531_17581511.01765.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136194ENST0000040187433401531_17581487.01741.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136194ENST0000043967332391531_17581451.01705.0DomainRap-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTSC2chr16:2747998chr16:2136193ENST0000021947635421531_17581554.01808.0DomainRap-GAP
TgeneTSC2chr16:2747998chr16:2136194ENST0000021947635421531_17581554.01808.0DomainRap-GAP


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Fusion Gene Sequence for KCTD5-TSC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000301738_ENST00000219476_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1391nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000219476_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000382538_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1379nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000382538_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000401874_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1381nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000401874_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000353929_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1390nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000353929_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000439673_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1380nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000439673_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000350773_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1391nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000350773_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000568454_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(transcript)=1394nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000568454_TCGA-OR-A5J1-01A_KCTD5_chr16_2747998_+_TSC2_chr16_2136194_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000219476_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1391nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000219476_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000382538_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1379nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000382538_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000401874_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1381nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000401874_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

--------------------------------------------------------------
>In-frame_ENST00000301738_ENST00000353929_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1390nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000353929_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

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>In-frame_ENST00000301738_ENST00000439673_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1380nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000439673_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

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>In-frame_ENST00000301738_ENST00000350773_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1391nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000350773_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

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>In-frame_ENST00000301738_ENST00000568454_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(transcript)=1394nt_BP=527nt
ACAGAACTCAGAGGACGCTATTAAAAGCCGGACGCTTCCGGTGGAAGGGAGCTGTTGCGGGGCTTGCTGGGATCATGGCGGAGAATCACT
GCGAGCTCCTGTCGCCGGCCCGGGGCGGCATCGGGGCGGGGCTGGGGGGCGGCCTGTGCCGCCGCTGCAGCGCTGGGCTCGGCGCCCTGG
CCCAGCGCCCTGGCAGCGTGTCCAAGTGGGTCCGACTCAACGTCGGCGGCACCTACTTCCTCACCACTCGGCAGACCCTGTGCCGGGACC
CGAAATCCTTCCTGTACCGCTTATGCCAGGCCGATCCCGACCTGGACTCAGACAAGGATGAAACAGGCGCCTATTTAATCGACAGAGACC
CCACCTACTTTGGGCCTGTGCTGAACTACCTGAGACACGGCAAGCTGGTGATTAACAAAGACCTCGCGGAGGAAGGAGTGTTGGAGGAAG
CAGAATTTTACAATATCACCTCATTAATAAAACTTGTAAAGGACAAAATTAGAGAACGAGACAGCAAAACATCGCAGAGCAACAGCGAGC
TCGCCATCCTGTCCAATGAGCATGGCTCCTACAGGTACACGGAGTTCCTGACGGGCCTGGGCCGGCTCATCGAGCTGAAGGACTGCCAGC
CGGACAAGGTGTACCTGGGAGGCCTGGACGTGTGTGGTGAGGACGGCCAGTTCACCTACTGCTGGCACGATGACATCATGCAAGCCGTCT
TCCACATCGCCACCCTGATGCCCACCAAGGACGTGGACAAGCACCGCTGCGACAAGAAGCGCCACCTGGGCAACGACTTTGTGTCCATTG
TCTACAATGACTCCGGTGAGGACTTCAAGCTTGGCACCATCAAGGGCCAGTTCAACTTTGTCCACGTGATCGTCACCCCGCTGGACTACG
AGTGCAACCTGGTGTCCCTGCAGTGCAGGAAAGACATGGAGGGCCTTGTGGACACCAGCGTGGCCAAGATCGTGTCTGACCGCAACCTGC
CCTTCGTGGCCCGCCAGATGGCCCTGCACGCAAATATGGCCTCACAGGTGCATCATAGCCGCTCCAACCCCACCGATATCTACCCCTCCA
AGTGGATTGCCCGGCTCCGCCACATCAAGCGGCTCCGCCAGCGGATCTGCGAGGAAGCCGCCTACTCCAACCCCAGCCTACCTCTGGTGC
ACCCTCCGTCCCATAGCAAAGCCCCTGCACAGACTCCAGCCGAGCCCACACCTGGCTATGAGGTGGGCCAGCGGAAGCGCCTCATCTCCT
CGGTGGAGGACTTCACCGAGTTTGTGTGAGGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAA

>In-frame_ENST00000301738_ENST00000568454_TCGA-OR-A5J1_KCTD5_chr16_2747998_+_TSC2_chr16_2136193_length(amino acids)=404AA_start in transcript=74_stop in transcript=1288
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAY
LIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQSNSELAILSNEHGSYRYTEFLTGLGRLIE
LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV
TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP

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Fusion Gene PPI Analysis for KCTD5-TSC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KCTD5-TSC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KCTD5-TSC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTSC2C1860707TUBEROUS SCLEROSIS 2 (disorder)21CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTSC2C0041341Tuberous Sclerosis14CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneTSC2C1854465TUBEROUS SCLEROSIS 1 (disorder)6CLINGEN
TgeneTSC2C0751674Lymphangioleiomyomatosis5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneTSC2C0265319Fibrous skin tumor of tuberous sclerosis4CTD_human
TgeneTSC2C0022665Kidney Neoplasm3CTD_human
TgeneTSC2C0740457Malignant neoplasm of kidney3CTD_human
TgeneTSC2C1846385FOCAL CORTICAL DYSPLASIA OF TAYLOR3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTSC2C0022333Jacksonian Seizure2CTD_human
TgeneTSC2C0036572Seizures2CTD_human
TgeneTSC2C0149958Complex partial seizures2CTD_human
TgeneTSC2C0234533Generalized seizures2CTD_human
TgeneTSC2C0234535Clonic Seizures2CTD_human
TgeneTSC2C0270824Visual seizure2CTD_human
TgeneTSC2C0270844Tonic Seizures2CTD_human
TgeneTSC2C0270846Epileptic drop attack2CTD_human
TgeneTSC2C0422850Seizures, Somatosensory2CTD_human
TgeneTSC2C0422852Seizures, Auditory2CTD_human
TgeneTSC2C0422853Olfactory seizure2CTD_human
TgeneTSC2C0422854Gustatory seizure2CTD_human
TgeneTSC2C0422855Vertiginous seizure2CTD_human
TgeneTSC2C0494475Tonic - clonic seizures2CTD_human
TgeneTSC2C0751056Non-epileptic convulsion2CTD_human
TgeneTSC2C0751110Single Seizure2CTD_human
TgeneTSC2C0751123Atonic Absence Seizures2CTD_human
TgeneTSC2C0751494Convulsive Seizures2CTD_human
TgeneTSC2C0751495Seizures, Focal2CTD_human
TgeneTSC2C0751496Seizures, Sensory2CTD_human
TgeneTSC2C1838327Polycystic kidneys, severe infantile with tuberous sclerosis2ORPHANET
TgeneTSC2C3495874Nonepileptic Seizures2CTD_human
TgeneTSC2C4048158Convulsions2CTD_human
TgeneTSC2C4316903Absence Seizures2CTD_human
TgeneTSC2C4317109Epileptic Seizures2CTD_human
TgeneTSC2C4317123Myoclonic Seizures2CTD_human
TgeneTSC2C4505436Generalized Absence Seizures2CTD_human
TgeneTSC2C0004352Autistic Disorder1CTD_human
TgeneTSC2C0006111Brain Diseases1CTD_human
TgeneTSC2C0007137Squamous cell carcinoma1CTD_human
TgeneTSC2C0014544Epilepsy1CTD_human
TgeneTSC2C0021368Inflammation1CTD_human
TgeneTSC2C0023267Fibroid Tumor1CTD_human
TgeneTSC2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneTSC2C0026640Mouth Neoplasms1CTD_human
TgeneTSC2C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneTSC2C0027746Nerve Degeneration1CTD_human
TgeneTSC2C0030297Pancreatic Neoplasm1CTD_human
TgeneTSC2C0032927Precancerous Conditions1CTD_human
TgeneTSC2C0037769West Syndrome1CTD_human
TgeneTSC2C0042133Uterine Fibroids1CTD_human
TgeneTSC2C0085584Encephalopathies1CTD_human
TgeneTSC2C0086237Epilepsy, Cryptogenic1CTD_human
TgeneTSC2C0153381Malignant neoplasm of mouth1CTD_human
TgeneTSC2C0236018Aura1CTD_human
TgeneTSC2C0279607Adult Hepatocellular Carcinoma1ORPHANET
TgeneTSC2C0282313Condition, Preneoplastic1CTD_human
TgeneTSC2C0346647Malignant neoplasm of pancreas1CTD_human
TgeneTSC2C0393698Cryptogenic Infantile Spasms1CTD_human
TgeneTSC2C0393699Symptomatic Infantile Spasms1CTD_human
TgeneTSC2C0546878Nodding spasm1CTD_human
TgeneTSC2C0553558Jackknife Seizures1CTD_human
TgeneTSC2C0684276Hypsarrhythmia1CTD_human
TgeneTSC2C0751111Awakening Epilepsy1CTD_human
TgeneTSC2C1527306spasmus nutans1CTD_human
TgeneTSC2C1527366Salaam Seizures1CTD_human
TgeneTSC2C1846386Focal Cortical Dysplasia of Taylor, Type IIa1CTD_human
TgeneTSC2C1846389Focal Cortical Dysplasia of Taylor, Type IIb1CTD_human
TgeneTSC2C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human