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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM2A-GDPD4 (FusionGDB2 ID:41529)

Fusion Gene Summary for KDM2A-GDPD4

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM2A-GDPD4
Fusion gene ID: 41529
HgeneTgene
Gene symbol

KDM2A

GDPD4

Gene ID

22992

220032

Gene namelysine demethylase 2Aglycerophosphodiester phosphodiesterase domain containing 4
SynonymsCXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINAGDE6
Cytomap

11q13.2

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing hglycerophosphodiester phosphodiesterase domain-containing protein 4GDPD domain containing proteinglycerophosphodiester phosphodiesterase 6ugpQ
Modification date2020032020200313
UniProtAcc

Q9Y2K7

.
Ensembl transtripts involved in fusion geneENST00000398645, ENST00000529006, 
ENST00000526258, ENST00000308783, 
ENST00000530342, 		ENST00000376217, 
ENST00000315938, ENST00000527489, 
Fusion gene scores* DoF score36 X 24 X 17=1468810 X 5 X 3=150
# samples 5011
** MAII scorelog2(50/14688*10)=-4.87656605875172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/150*10)=-0.447458976971221
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM2A [Title/Abstract] AND GDPD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM2A(66983420)-GDPD4(76998465), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KDM2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GDPD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A6SC-01AKDM2Achr11

66983420

+GDPD4chr11

76998465

-


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Fusion Gene ORF analysis for KDM2A-GDPD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398645ENST00000376217KDM2Achr11

66983420

+GDPD4chr11

76998465

-
In-frameENST00000398645ENST00000315938KDM2Achr11

66983420

+GDPD4chr11

76998465

-
5CDS-5UTRENST00000398645ENST00000527489KDM2Achr11

66983420

+GDPD4chr11

76998465

-
In-frameENST00000529006ENST00000376217KDM2Achr11

66983420

+GDPD4chr11

76998465

-
In-frameENST00000529006ENST00000315938KDM2Achr11

66983420

+GDPD4chr11

76998465

-
5CDS-5UTRENST00000529006ENST00000527489KDM2Achr11

66983420

+GDPD4chr11

76998465

-
3UTR-3CDSENST00000526258ENST00000376217KDM2Achr11

66983420

+GDPD4chr11

76998465

-
3UTR-3CDSENST00000526258ENST00000315938KDM2Achr11

66983420

+GDPD4chr11

76998465

-
3UTR-5UTRENST00000526258ENST00000527489KDM2Achr11

66983420

+GDPD4chr11

76998465

-
intron-3CDSENST00000308783ENST00000376217KDM2Achr11

66983420

+GDPD4chr11

76998465

-
intron-3CDSENST00000308783ENST00000315938KDM2Achr11

66983420

+GDPD4chr11

76998465

-
intron-5UTRENST00000308783ENST00000527489KDM2Achr11

66983420

+GDPD4chr11

76998465

-
intron-3CDSENST00000530342ENST00000376217KDM2Achr11

66983420

+GDPD4chr11

76998465

-
intron-3CDSENST00000530342ENST00000315938KDM2Achr11

66983420

+GDPD4chr11

76998465

-
intron-5UTRENST00000530342ENST00000527489KDM2Achr11

66983420

+GDPD4chr11

76998465

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398645KDM2Achr1166983420+ENST00000376217GDPD4chr1176998465-4053155117363673645
ENST00000398645KDM2Achr1166983420+ENST00000315938GDPD4chr1176998465-4084155117363364542
ENST00000529006KDM2Achr1166983420+ENST00000376217GDPD4chr1176998465-3635113313183255645
ENST00000529006KDM2Achr1166983420+ENST00000315938GDPD4chr1176998465-3666113313182946542

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398645ENST00000376217KDM2Achr1166983420+GDPD4chr1176998465-0.0056236910.9943763
ENST00000398645ENST00000315938KDM2Achr1166983420+GDPD4chr1176998465-0.0084186610.9915814
ENST00000529006ENST00000376217KDM2Achr1166983420+GDPD4chr1176998465-0.0050610450.99493897
ENST00000529006ENST00000315938KDM2Achr1166983420+GDPD4chr1176998465-0.0078171180.9921829

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Fusion Genomic Features for KDM2A-GDPD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KDM2A-GDPD4


check button Go to

FGviewer for the breakpoints of chr11:66983420-chr11:76998465

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM2A

Q9Y2K7

.
FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116198_4570521.0DomainNote=GP-PDE
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117198_4570624.0DomainNote=GP-PDE
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116131_1620521.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116184_4680521.0Topological domainExtracellular
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-1161_170521.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-11639_390521.0Topological domainExtracellular
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116490_6230521.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-11661_690521.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-11691_1090521.0Topological domainExtracellular
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117131_1620624.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117184_4680624.0Topological domainExtracellular
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-1171_170624.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-11739_390624.0Topological domainExtracellular
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117490_6230624.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-11761_690624.0Topological domainCytoplasmic
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-11791_1090624.0Topological domainExtracellular
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116110_1300521.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116163_1830521.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-11618_380521.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-11640_600521.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-116469_4890521.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000315938-11670_900521.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117110_1300624.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117163_1830624.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-11718_380624.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-11740_600624.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-117469_4890624.0TransmembraneHelical
TgeneGDPD4chr11:66983420chr11:76998465ENST00000376217-11770_900624.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+110148_3160621.0DomainJmjC
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+110889_9360621.0DomainNote=F-box
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+821148_316229.01490.3333333333333DomainJmjC
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+821889_936229.01490.3333333333333DomainNote=F-box
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+821148_316229.01163.0DomainJmjC
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+821889_936229.01163.0DomainNote=F-box
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+110148_3160724.0DomainJmjC
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+110889_9360724.0DomainNote=F-box
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+1101048_10730621.0RepeatNote=LRR 3
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+1101074_11030621.0RepeatNote=LRR 4
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+1101104_11280621.0RepeatNote=LRR 5
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+1101129_11560621.0RepeatNote=LRR 6
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+110961_9820621.0RepeatNote=LRR 1
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+110984_10100621.0RepeatNote=LRR 2
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+8211048_1073229.01490.3333333333333RepeatNote=LRR 3
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+8211074_1103229.01490.3333333333333RepeatNote=LRR 4
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+8211104_1128229.01490.3333333333333RepeatNote=LRR 5
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+8211129_1156229.01490.3333333333333RepeatNote=LRR 6
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+821961_982229.01490.3333333333333RepeatNote=LRR 1
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+821984_1010229.01490.3333333333333RepeatNote=LRR 2
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+8211048_1073229.01163.0RepeatNote=LRR 3
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+8211074_1103229.01163.0RepeatNote=LRR 4
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+8211104_1128229.01163.0RepeatNote=LRR 5
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+8211129_1156229.01163.0RepeatNote=LRR 6
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+821961_982229.01163.0RepeatNote=LRR 1
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+821984_1010229.01163.0RepeatNote=LRR 2
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+1101048_10730724.0RepeatNote=LRR 3
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+1101074_11030724.0RepeatNote=LRR 4
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+1101104_11280724.0RepeatNote=LRR 5
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+1101129_11560724.0RepeatNote=LRR 6
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+110961_9820724.0RepeatNote=LRR 1
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+110984_10100724.0RepeatNote=LRR 2
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+110564_6100621.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000308783+110617_6780621.0Zinc fingerPHD-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+821564_610229.01490.3333333333333Zinc fingerCXXC-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000398645+821617_678229.01490.3333333333333Zinc fingerPHD-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+821564_610229.01163.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000529006+821617_678229.01163.0Zinc fingerPHD-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+110564_6100724.0Zinc fingerCXXC-type
HgeneKDM2Achr11:66983420chr11:76998465ENST00000530342+110617_6780724.0Zinc fingerPHD-type


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Fusion Gene Sequence for KDM2A-GDPD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398645_ENST00000376217_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(transcript)=4053nt_BP=1551nt
GAGTCTGACGGGTTCAAAATGGCGGCGGCTGCTTCAGCGGCTCCTCCTGTGTGAGGGAAACAACACCCCTCCCCGGCAGCGGCGGCGGCG
GCGGCGGCTCTCGGAGCACCTTCCCAGCGGCTGGGCCCGTGGCCGCTCTGTCTTTCCTGGGCAGGGGACGCTCCGGGAGGAGGGGCAACG
CCAGGGGGCCCATCCCCCGGAATCCCTCTTCTGCGACTGGGGAGTAGCCGGGGGGCTCGTCCCGCAGCGCGGAGCCAGACCTGAGGGGGA
GACGCGAGGGGAGCCAGGGCCCCCATCCCGGCGCGCCGCGCCGCTCCCGCCCTGTCCGCCCCCCGGGGCCGGGGCCCGCGTTCCGGGGGG
CCGGGGCGGCGCGGGGAGCCTCGGGCCGGCCGGTCTCAGCTGATCGGCCGCTGCTCCCGCAGGCGACCAGCCCCTGCTGGCCGAGGGCAC
GGCGAGGAGGGCGCTCCCTGCGGCCGGGGCCGGCCCGGGGCTCGGGCCCGGGCTGCTGACCGCTGGCCTGGGGGAGGCGGGGGCGCCCCG
GGCTCGGCGCCGAGGGGTCGCGCTCCTCTCTCCTGACGCCTCCGACTCCCGGTCTCCAAAGCCAGAAGAGAAGGTTTGATTCAGCAACTG
TTTGCTCCCTTTTCCTGGTCGCTCTGACCCTCTCTGGATACTGGGTTGATCCACGGAAAAACCGAAGACGACGTTTGGGATTTAATTATT
CCTCTCAGCTTTGGAATCTTTTACTTCTCACTTGGACAAGAACTCAAGAGCAGAATCTCCGTGTTGCAATCTGGTTCCTAAGGAGGAAGA
GGAAGGCAGCCCTGGAGTGGTTTCTTTACAGTAATTTCAACAGAAGAGTGAGAGATGGAACCCGAAGAAGAAAGGATTCGTTACAGCCAG
AGATTGCGTGGTACCATGCGACGACGCTATGAAGATGATGGCATTTCAGATGATGAAATTGAAGGAAAAAGAACTTTTGACTTGGAAGAG
AAACTGCACACCAACAAATATAATGCCAATTTTGTTACTTTTATGGAAGGAAAAGATTTTAATGTAGAGTATATTCAGCGGGGTGGCTTG
AGAGATCCTCTGATTTTCAAGAATTCTGATGGACTCGGAATAAAAATGCCGGATCCAGACTTCACTGTGAATGATGTCAAAATGTGTGTG
GGGAGTCGTCGCATGGTGGATGTCATGGACGTGAACACACAGAAAGGCATTGAAATGACCATGGCTCAGTGGACACGCTACTATGAGACC
CCAGAGGAGGAGCGAGAGAAACTCTATAATGTCATCAGCCTCGAGTTTAGCCACACCAGGCTGGAGAATATGGTGCAGAGGCCCTCCACG
GTGGATTTCATTGACTGGGTAGACAACATGTGGCCAAGGCACTTGAAGGAAAGCCAGACTGAATCAACAAATGCCATCTTGGAGATGCAG
TACCCTAAAGTGCAGAAGTACTGTCTAATGAGTGTTCGAGGCTGCTATACTGACTTCCATGTGGACTTTGGTGGTACCTCTGTTTGGTAT
CACATCCATCAAGGGGGAAAGAAAGGGTGAATCATGTTTAAGAAGGTCAACAGGATTGAGCACAAGAGGAATAAGACAGAAAAACCAAAA
AAGCTTAATCCATGGATTCCACGCATCTTCAACCACAAATGCTTTGTCACCTTCCTTACTGGCTGCTATAGTTGCCTCTGGAAATTCAGA
CAATGGGAAAAAACTAAAGTTGGATTTTGTTGCTGCACTTGGAAAGAGCAATTATTTTGCCGTGCCTGGTAATTTCATTTGTCTTGTCTC
TGATGTTGCTGTTCCTGTGGATAGAAACATCCAGTGAATACTTTAACTTTGACTGGGTCACTTTTCTAGGAACAGGATACTGGTTTTTCT
GGTCTATTTTTATTCTGAGTTTAGCTAGGATCCTGACTGCCTACTCTTCATTGCTGTTGTTACTTGGATTTTTGTTGCTTTGGGAAAGGA
TTGAACTATACCTGCACTTGTGTCATAAGATCCTGATTCTGCTAGTGATTCTTCTGTGTGTCATTTTAATGTTCATTATATGCAAATTCT
GGAAAGAAAGGTGGCTGGTAGCTGGGCTGTCAATGCAGATCTTTGCTCCCTACGTGCACCTGGTCAGCATAACTGTGATGGTTATCCTTT
TCTGGCCTGTGGCCTTCTACGTGGCATGTTTGGAAAGAGAAGTTAGAATGAGAAGATACAGGATGACACATTCTGAGAAAAAAAGACTCA
AGCAATGTAATGTAATCACAAGGTTAAGAGGTCTACAAGTGCCTGTTGGATTACCCTTTCTTCTTATCCTTTTAGGTCTCTATTTGATGC
CACTGGGGATTTATTCTCCCTGCATTCAGGAGAAGGAGAATTTGGGGCCCAAGCCAACCATCTTTGGACATAGAGGTGCACCCATGTTGG
GGCCTGAGAATACCATGATGTCCTTTGAGAAAGCTGTTGAACATGGAGCCCATGGATTGGAGACTGATATACACTTAAGTTATGATCATG
TGCCTTTCCTCATGCATGACTTTGACCTGAAAAGAACAACCAATATTGGGGAAGTTCAGCCAGAATCTGCCTGCGAGAACCCTGCCTTCT
TCAACTGGGATTTCCTATCGACTCTGAATGCAGGCAAATGGTTTGTAAAACCAGAGCTCAGGCCATTTTACAATATGAAACCTCTATCAG
AGGCAGATAAAGAAAGAGCAAGAAATCAGTCAATTCCAACACTAGCTGATTTATTGACACTTGCAGAGAAGGAAAGAAAATTTGTGATAT
TTGATCTTCATCGCCCTCCACCAAAACATCCTCTCAGACACACATTTGTCCGCCAAGTAGTAAGCGTGATCCTTGCCTCTAAAATCGAGC
AACATCTGATTTTTTGGTTGCCAGCTCATGATAGGCAATACGTCAGGTCCGTGGCTCCTGGTTTTCAGCATGTGGGCCGTTTAGTATCCA
TTGAAACCCTTGCTAAAAACAATATCAGTATAATAAATGTTGACTACAAGAAGTTGTTCCCTAATGGGTTAAGAGATTATAAAGCAGCTA
ACATCCATATCAACGTATACACCGTCAATGAGCCTTGGCTTTTCTCACTGGCCTGGTGCTCCAGGATTAACTCAGTGACCACAGACAACA
TTGGGCTCCTGAGTCAGCTTGATCACCCTCACTTCTTCATGACACCAAAGTTCTATGTGTTCATGTGGCTCCTTGCAGATATCATTTCTG
TGCTTTTTATTGTTGCCATATTTTGTTTTCACTGGCGGAGAGAGACTGAAAAAGAAAAATTGTTTGAAACCTCCAGCACTCGCACAGATA
CTCAGAGTGGAAATTTGCACATAGCCATGAAACCTCCTGTCCGAGTTGTGGAAGGTCCTTGGACTCTAGCAGCCCTCTACCCGGCTCTAC
CCAAGAGTGGAAAGGAACACCAAGGCCATTTCAATTTTGCAGCACCATCCAAGAAACTACTACCTATCAAGAATGCTGTCACACCTTTGA
AGCCTGGCAAGCATGAGATTCAACCACCGATGCCCACCGTGGTCTTTGAACTCACCCAAGCACCCACCAGGCAGGCTACAAGTGAGGCTA
CCTTTCAAACTACATTGCCCACCCTGAAGGTGGATAAGCCAACCATGCCCTCCATAGAGGTCCCCTATCCTTAAATAAGAGACCTCTAAG
AGATCCCCATGGCTGAATACTCCAAATAATCCTATGTCACAATATATTCCATTGCATCTGACATAGCCTTCTGTGTTTCCAAAGAAGAAT
TAGCCACATCTCCCCTGCTTCTTCCTCTCTCTGCCTAAGGGTGGTGATGGTGGGGAGTGGTTGATAAAGGCACACAGAAGGGCCACGGAG
GCTCTCAGGGGAACCATTGTGCTCTCGCTATCAAGAATGCATCTCAAGGGGCTAGGCAAGGGGAAAACTGCTGTGTGTGGTCTTGGAACT
GGTTGCTGTCAGGTTTATCTCATCCTAACACCTCCATAATATTTTCTGCTAAAGGAGTGACTGTGCATATAAGTAAAGGCAACCTCTCAG

>In-frame_ENST00000398645_ENST00000376217_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(amino acids)=645AA_start in transcript=1736_stop in transcript=3673
MLLHLERAIILPCLVISFVLSLMLLFLWIETSSEYFNFDWVTFLGTGYWFFWSIFILSLARILTAYSSLLLLLGFLLLWERIELYLHLCH
KILILLVILLCVILMFIICKFWKERWLVAGLSMQIFAPYVHLVSITVMVILFWPVAFYVACLEREVRMRRYRMTHSEKKRLKQCNVITRL
RGLQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLGPKPTIFGHRGAPMLGPENTMMSFEKAVEHGAHGLETDIHLSYDHVPFLMHDFD
LKRTTNIGEVQPESACENPAFFNWDFLSTLNAGKWFVKPELRPFYNMKPLSEADKERARNQSIPTLADLLTLAEKERKFVIFDLHRPPPK
HPLRHTFVRQVVSVILASKIEQHLIFWLPAHDRQYVRSVAPGFQHVGRLVSIETLAKNNISIINVDYKKLFPNGLRDYKAANIHINVYTV
NEPWLFSLAWCSRINSVTTDNIGLLSQLDHPHFFMTPKFYVFMWLLADIISVLFIVAIFCFHWRRETEKEKLFETSSTRTDTQSGNLHIA
MKPPVRVVEGPWTLAALYPALPKSGKEHQGHFNFAAPSKKLLPIKNAVTPLKPGKHEIQPPMPTVVFELTQAPTRQATSEATFQTTLPTL

--------------------------------------------------------------
>In-frame_ENST00000398645_ENST00000315938_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(transcript)=4084nt_BP=1551nt
GAGTCTGACGGGTTCAAAATGGCGGCGGCTGCTTCAGCGGCTCCTCCTGTGTGAGGGAAACAACACCCCTCCCCGGCAGCGGCGGCGGCG
GCGGCGGCTCTCGGAGCACCTTCCCAGCGGCTGGGCCCGTGGCCGCTCTGTCTTTCCTGGGCAGGGGACGCTCCGGGAGGAGGGGCAACG
CCAGGGGGCCCATCCCCCGGAATCCCTCTTCTGCGACTGGGGAGTAGCCGGGGGGCTCGTCCCGCAGCGCGGAGCCAGACCTGAGGGGGA
GACGCGAGGGGAGCCAGGGCCCCCATCCCGGCGCGCCGCGCCGCTCCCGCCCTGTCCGCCCCCCGGGGCCGGGGCCCGCGTTCCGGGGGG
CCGGGGCGGCGCGGGGAGCCTCGGGCCGGCCGGTCTCAGCTGATCGGCCGCTGCTCCCGCAGGCGACCAGCCCCTGCTGGCCGAGGGCAC
GGCGAGGAGGGCGCTCCCTGCGGCCGGGGCCGGCCCGGGGCTCGGGCCCGGGCTGCTGACCGCTGGCCTGGGGGAGGCGGGGGCGCCCCG
GGCTCGGCGCCGAGGGGTCGCGCTCCTCTCTCCTGACGCCTCCGACTCCCGGTCTCCAAAGCCAGAAGAGAAGGTTTGATTCAGCAACTG
TTTGCTCCCTTTTCCTGGTCGCTCTGACCCTCTCTGGATACTGGGTTGATCCACGGAAAAACCGAAGACGACGTTTGGGATTTAATTATT
CCTCTCAGCTTTGGAATCTTTTACTTCTCACTTGGACAAGAACTCAAGAGCAGAATCTCCGTGTTGCAATCTGGTTCCTAAGGAGGAAGA
GGAAGGCAGCCCTGGAGTGGTTTCTTTACAGTAATTTCAACAGAAGAGTGAGAGATGGAACCCGAAGAAGAAAGGATTCGTTACAGCCAG
AGATTGCGTGGTACCATGCGACGACGCTATGAAGATGATGGCATTTCAGATGATGAAATTGAAGGAAAAAGAACTTTTGACTTGGAAGAG
AAACTGCACACCAACAAATATAATGCCAATTTTGTTACTTTTATGGAAGGAAAAGATTTTAATGTAGAGTATATTCAGCGGGGTGGCTTG
AGAGATCCTCTGATTTTCAAGAATTCTGATGGACTCGGAATAAAAATGCCGGATCCAGACTTCACTGTGAATGATGTCAAAATGTGTGTG
GGGAGTCGTCGCATGGTGGATGTCATGGACGTGAACACACAGAAAGGCATTGAAATGACCATGGCTCAGTGGACACGCTACTATGAGACC
CCAGAGGAGGAGCGAGAGAAACTCTATAATGTCATCAGCCTCGAGTTTAGCCACACCAGGCTGGAGAATATGGTGCAGAGGCCCTCCACG
GTGGATTTCATTGACTGGGTAGACAACATGTGGCCAAGGCACTTGAAGGAAAGCCAGACTGAATCAACAAATGCCATCTTGGAGATGCAG
TACCCTAAAGTGCAGAAGTACTGTCTAATGAGTGTTCGAGGCTGCTATACTGACTTCCATGTGGACTTTGGTGGTACCTCTGTTTGGTAT
CACATCCATCAAGGGGGAAAGAAAGGGTGAATCATGTTTAAGAAGGTCAACAGGATTGAGCACAAGAGGAATAAGACAGAAAAACCAAAA
AAGCTTAATCCATGGATTCCACGCATCTTCAACCACAAATGCTTTGTCACCTTCCTTACTGGCTGCTATAGTTGCCTCTGGAAATTCAGA
CAATGGGAAAAAACTAAAGTTGGATTTTGTTGCTGCACTTGGAAAGAGCAATTATTTTGCCGTGCCTGGTAATTTCATTTGTCTTGTCTC
TGATGTTGCTGTTCCTGTGGATAGAAACATCCAGTGAATACTTTAACTTTGACTGGGTCACTTTTCTAGGAACAGGATACTGGTTTTTCT
GGTCTATTTTTATTCTGAGTTTAGCTAGGATCCTGACTGCCTACTCTTCATTGCTGTTGTTACTTGGATTTTTGTTGCTTTGGGAAAGGA
TTGAACTATACCTGCACTTGTGTCATAAGATCCTGATTCTGCTAGTGATTCTTCTGTGTGTCATTTTAATGTTCATTATATGCAAATTCT
GGAAAGAAAGGTGGCTGGTAGCTGGGCTGTCAATGCAGATCTTTGCTCCCTACGTGCACCTGGTCAGCATAACTGTGATGGTTATCCTTT
TCTGGCCTGTGGCCTTCTACGTGGCATGTTTGGAAAGAGAAGTTAGAATGAGAAGATACAGGATGACACATTCTGAGAAAAAAAGACTCA
AGCAATGTAATGTAATCACAAGGTTAAGAGGTCTACAAGTGCCTGTTGGATTACCCTTTCTTCTTATCCTTTTAGGTCTCTATTTGATGC
CACTGGGGATTTATTCTCCCTGCATTCAGGAGAAGGAGAATTTGGGGCCCAAGCCAACCATCTTTGGACATAGAGGTGCACCCATGTTGG
GGCCTGAGAATACCATGATGTCCTTTGAGAAAGCTGTTGAACATGGAGCCCATGGATTGGAGACTGATATACACTTAAGTTATGATCATG
TGCCTTTCCTCATGCATGACTTTGACCTGAAAAGAACAACCAATATTGGGGAAGTTCAGCCAGAATCTGCCTGCGAGAACCCTGCCTTCT
TCAACTGGGATTTCCTATCGACTCTGAATGCAGGCAAATGGTTTGTAAAACCAGAGCTCAGGCCATTTTACAATATGAAACCTCTATCAG
AGGCAGATAAAGAAAGAGCAAGAAATCAGTCAATTCCAACACTAGCTGATTTATTGACACTTGCAGAGAAGGAAAGAAAATTTGTGATAT
TTGATCTTCATCGCCCTCCACCAAAACATCCTCTCAGACACACATTTGTCCGCCAAGTAGTAAGCGTGATCCTTGCCTCTAAAATCGAGC
AACATCTGATTTTTTGGTTGCCAGCTCATGATAGGCAATACGTCAGGTCCGTGGCTCCTGGTTTTCAGCATGTGGGCCGTTTAGTATCCA
TTGAAACCCTTGCTAAAAACAATATCAGTATAATAAATGTTGACTACAAGAAGTTGTTCCCTAATGGGTTAAGAGATTATAAAGCAGCTA
ACATCCATATCAACGTATACACCGTCAATGAGCCTTGGCTTTTCTCACTGGCCTGGTGCTCCAGGATTAACTCAGTGACCACAGACAACA
TTGGGCTCCTGAGTCAGCTTGATCACCCTCACTTCTTCATGACACCAAAGTTCTATGTGTTCATGTGGCTCCTTGCAGATATCATTTCTG
TGCTTTTTATTGTTGCCATATTTTGTTTTCACTGGCGGAGAGAGACTGAAAAAGAAAAATTGTTTGAAACCTCCAGCACTCGCACAGATA
CTCAGAGTGGAAGTAAGAATGAGGAAGATAGATAGATAGATAGATTTGCACATAGCCATGAAACCTCCTGTCCGAGTTGTGGAAGGTCCT
TGGACTCTAGCAGCCCTCTACCCGGCTCTACCCAAGAGTGGAAAGGAACACCAAGGCCATTTCAATTTTGCAGCACCATCCAAGAAACTA
CTACCTATCAAGAATGCTGTCACACCTTTGAAGCCTGGCAAGCATGAGATTCAACCACCGATGCCCACCGTGGTCTTTGAACTCACCCAA
GCACCCACCAGGCAGGCTACAAGTGAGGCTACCTTTCAAACTACATTGCCCACCCTGAAGGTGGATAAGCCAACCATGCCCTCCATAGAG
GTCCCCTATCCTTAAATAAGAGACCTCTAAGAGATCCCCATGGCTGAATACTCCAAATAATCCTATGTCACAATATATTCCATTGCATCT
GACATAGCCTTCTGTGTTTCCAAAGAAGAATTAGCCACATCTCCCCTGCTTCTTCCTCTCTCTGCCTAAGGGTGGTGATGGTGGGGAGTG
GTTGATAAAGGCACACAGAAGGGCCACGGAGGCTCTCAGGGGAACCATTGTGCTCTCGCTATCAAGAATGCATCTCAAGGGGCTAGGCAA
GGGGAAAACTGCTGTGTGTGGTCTTGGAACTGGTTGCTGTCAGGTTTATCTCATCCTAACACCTCCATAATATTTTCTGCTAAAGGAGTG

>In-frame_ENST00000398645_ENST00000315938_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(amino acids)=542AA_start in transcript=1736_stop in transcript=3364
MLLHLERAIILPCLVISFVLSLMLLFLWIETSSEYFNFDWVTFLGTGYWFFWSIFILSLARILTAYSSLLLLLGFLLLWERIELYLHLCH
KILILLVILLCVILMFIICKFWKERWLVAGLSMQIFAPYVHLVSITVMVILFWPVAFYVACLEREVRMRRYRMTHSEKKRLKQCNVITRL
RGLQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLGPKPTIFGHRGAPMLGPENTMMSFEKAVEHGAHGLETDIHLSYDHVPFLMHDFD
LKRTTNIGEVQPESACENPAFFNWDFLSTLNAGKWFVKPELRPFYNMKPLSEADKERARNQSIPTLADLLTLAEKERKFVIFDLHRPPPK
HPLRHTFVRQVVSVILASKIEQHLIFWLPAHDRQYVRSVAPGFQHVGRLVSIETLAKNNISIINVDYKKLFPNGLRDYKAANIHINVYTV
NEPWLFSLAWCSRINSVTTDNIGLLSQLDHPHFFMTPKFYVFMWLLADIISVLFIVAIFCFHWRRETEKEKLFETSSTRTDTQSGSKNEE

--------------------------------------------------------------
>In-frame_ENST00000529006_ENST00000376217_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(transcript)=3635nt_BP=1133nt
GCAGGCGACCAGCCCCTGCTGGCCGAGGGCACGGCGAGGAGGGCGCTCCCTGCGGCCGGGGCCGGCCCGGGGCTCGGGCCCGGGCTGCTG
ACCGCTGGCCTGGGGGAGGCGGGGGCGCCCCGGGCTCGGCGCCGAGGGGTCGCGCTCCTCTCTCCTGACGCCTCCGACTCCCGGTCTCCA
AAGCCAGAAGAGAAGGTTTGATTCAGCAACTGTTTGCTCCCTTTTCCTGGTCGCTCTGACCCTCTCTGGATACTGGGTTGATCCACGGAA
AAACCGAAGACGACGTTTGGGATTTAATTATTCCTCTCAGCTTTGGAATCTTTTACTTCTCACTTGGACAAGAACTCAAGAGCAGAATCT
CCGTGTTGCAATCTGGTTCCTAAGGAGGAAGAGGAAGGCAGCCCTGGAGTGGTTTCTTTACAGTAATTTCAACAGAAGAGTGAGAGATGG
AACCCGAAGAAGAAAGGATTCGTTACAGCCAGAGATTGCGTGGTACCATGCGACGACGCTATGAAGATGATGGCATTTCAGATGATGAAA
TTGAAGGAAAAAGAACTTTTGACTTGGAAGAGAAACTGCACACCAACAAATATAATGCCAATTTTGTTACTTTTATGGAAGGAAAAGATT
TTAATGTAGAGTATATTCAGCGGGGTGGCTTGAGAGATCCTCTGATTTTCAAGAATTCTGATGGACTCGGAATAAAAATGCCGGATCCAG
ACTTCACTGTGAATGATGTCAAAATGTGTGTGGGGAGTCGTCGCATGGTGGATGTCATGGACGTGAACACACAGAAAGGCATTGAAATGA
CCATGGCTCAGTGGACACGCTACTATGAGACCCCAGAGGAGGAGCGAGAGAAACTCTATAATGTCATCAGCCTCGAGTTTAGCCACACCA
GGCTGGAGAATATGGTGCAGAGGCCCTCCACGGTGGATTTCATTGACTGGGTAGACAACATGTGGCCAAGGCACTTGAAGGAAAGCCAGA
CTGAATCAACAAATGCCATCTTGGAGATGCAGTACCCTAAAGTGCAGAAGTACTGTCTAATGAGTGTTCGAGGCTGCTATACTGACTTCC
ATGTGGACTTTGGTGGTACCTCTGTTTGGTATCACATCCATCAAGGGGGAAAGAAAGGGTGAATCATGTTTAAGAAGGTCAACAGGATTG
AGCACAAGAGGAATAAGACAGAAAAACCAAAAAAGCTTAATCCATGGATTCCACGCATCTTCAACCACAAATGCTTTGTCACCTTCCTTA
CTGGCTGCTATAGTTGCCTCTGGAAATTCAGACAATGGGAAAAAACTAAAGTTGGATTTTGTTGCTGCACTTGGAAAGAGCAATTATTTT
GCCGTGCCTGGTAATTTCATTTGTCTTGTCTCTGATGTTGCTGTTCCTGTGGATAGAAACATCCAGTGAATACTTTAACTTTGACTGGGT
CACTTTTCTAGGAACAGGATACTGGTTTTTCTGGTCTATTTTTATTCTGAGTTTAGCTAGGATCCTGACTGCCTACTCTTCATTGCTGTT
GTTACTTGGATTTTTGTTGCTTTGGGAAAGGATTGAACTATACCTGCACTTGTGTCATAAGATCCTGATTCTGCTAGTGATTCTTCTGTG
TGTCATTTTAATGTTCATTATATGCAAATTCTGGAAAGAAAGGTGGCTGGTAGCTGGGCTGTCAATGCAGATCTTTGCTCCCTACGTGCA
CCTGGTCAGCATAACTGTGATGGTTATCCTTTTCTGGCCTGTGGCCTTCTACGTGGCATGTTTGGAAAGAGAAGTTAGAATGAGAAGATA
CAGGATGACACATTCTGAGAAAAAAAGACTCAAGCAATGTAATGTAATCACAAGGTTAAGAGGTCTACAAGTGCCTGTTGGATTACCCTT
TCTTCTTATCCTTTTAGGTCTCTATTTGATGCCACTGGGGATTTATTCTCCCTGCATTCAGGAGAAGGAGAATTTGGGGCCCAAGCCAAC
CATCTTTGGACATAGAGGTGCACCCATGTTGGGGCCTGAGAATACCATGATGTCCTTTGAGAAAGCTGTTGAACATGGAGCCCATGGATT
GGAGACTGATATACACTTAAGTTATGATCATGTGCCTTTCCTCATGCATGACTTTGACCTGAAAAGAACAACCAATATTGGGGAAGTTCA
GCCAGAATCTGCCTGCGAGAACCCTGCCTTCTTCAACTGGGATTTCCTATCGACTCTGAATGCAGGCAAATGGTTTGTAAAACCAGAGCT
CAGGCCATTTTACAATATGAAACCTCTATCAGAGGCAGATAAAGAAAGAGCAAGAAATCAGTCAATTCCAACACTAGCTGATTTATTGAC
ACTTGCAGAGAAGGAAAGAAAATTTGTGATATTTGATCTTCATCGCCCTCCACCAAAACATCCTCTCAGACACACATTTGTCCGCCAAGT
AGTAAGCGTGATCCTTGCCTCTAAAATCGAGCAACATCTGATTTTTTGGTTGCCAGCTCATGATAGGCAATACGTCAGGTCCGTGGCTCC
TGGTTTTCAGCATGTGGGCCGTTTAGTATCCATTGAAACCCTTGCTAAAAACAATATCAGTATAATAAATGTTGACTACAAGAAGTTGTT
CCCTAATGGGTTAAGAGATTATAAAGCAGCTAACATCCATATCAACGTATACACCGTCAATGAGCCTTGGCTTTTCTCACTGGCCTGGTG
CTCCAGGATTAACTCAGTGACCACAGACAACATTGGGCTCCTGAGTCAGCTTGATCACCCTCACTTCTTCATGACACCAAAGTTCTATGT
GTTCATGTGGCTCCTTGCAGATATCATTTCTGTGCTTTTTATTGTTGCCATATTTTGTTTTCACTGGCGGAGAGAGACTGAAAAAGAAAA
ATTGTTTGAAACCTCCAGCACTCGCACAGATACTCAGAGTGGAAATTTGCACATAGCCATGAAACCTCCTGTCCGAGTTGTGGAAGGTCC
TTGGACTCTAGCAGCCCTCTACCCGGCTCTACCCAAGAGTGGAAAGGAACACCAAGGCCATTTCAATTTTGCAGCACCATCCAAGAAACT
ACTACCTATCAAGAATGCTGTCACACCTTTGAAGCCTGGCAAGCATGAGATTCAACCACCGATGCCCACCGTGGTCTTTGAACTCACCCA
AGCACCCACCAGGCAGGCTACAAGTGAGGCTACCTTTCAAACTACATTGCCCACCCTGAAGGTGGATAAGCCAACCATGCCCTCCATAGA
GGTCCCCTATCCTTAAATAAGAGACCTCTAAGAGATCCCCATGGCTGAATACTCCAAATAATCCTATGTCACAATATATTCCATTGCATC
TGACATAGCCTTCTGTGTTTCCAAAGAAGAATTAGCCACATCTCCCCTGCTTCTTCCTCTCTCTGCCTAAGGGTGGTGATGGTGGGGAGT
GGTTGATAAAGGCACACAGAAGGGCCACGGAGGCTCTCAGGGGAACCATTGTGCTCTCGCTATCAAGAATGCATCTCAAGGGGCTAGGCA
AGGGGAAAACTGCTGTGTGTGGTCTTGGAACTGGTTGCTGTCAGGTTTATCTCATCCTAACACCTCCATAATATTTTCTGCTAAAGGAGT

>In-frame_ENST00000529006_ENST00000376217_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(amino acids)=645AA_start in transcript=1318_stop in transcript=3255
MLLHLERAIILPCLVISFVLSLMLLFLWIETSSEYFNFDWVTFLGTGYWFFWSIFILSLARILTAYSSLLLLLGFLLLWERIELYLHLCH
KILILLVILLCVILMFIICKFWKERWLVAGLSMQIFAPYVHLVSITVMVILFWPVAFYVACLEREVRMRRYRMTHSEKKRLKQCNVITRL
RGLQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLGPKPTIFGHRGAPMLGPENTMMSFEKAVEHGAHGLETDIHLSYDHVPFLMHDFD
LKRTTNIGEVQPESACENPAFFNWDFLSTLNAGKWFVKPELRPFYNMKPLSEADKERARNQSIPTLADLLTLAEKERKFVIFDLHRPPPK
HPLRHTFVRQVVSVILASKIEQHLIFWLPAHDRQYVRSVAPGFQHVGRLVSIETLAKNNISIINVDYKKLFPNGLRDYKAANIHINVYTV
NEPWLFSLAWCSRINSVTTDNIGLLSQLDHPHFFMTPKFYVFMWLLADIISVLFIVAIFCFHWRRETEKEKLFETSSTRTDTQSGNLHIA
MKPPVRVVEGPWTLAALYPALPKSGKEHQGHFNFAAPSKKLLPIKNAVTPLKPGKHEIQPPMPTVVFELTQAPTRQATSEATFQTTLPTL

--------------------------------------------------------------
>In-frame_ENST00000529006_ENST00000315938_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(transcript)=3666nt_BP=1133nt
GCAGGCGACCAGCCCCTGCTGGCCGAGGGCACGGCGAGGAGGGCGCTCCCTGCGGCCGGGGCCGGCCCGGGGCTCGGGCCCGGGCTGCTG
ACCGCTGGCCTGGGGGAGGCGGGGGCGCCCCGGGCTCGGCGCCGAGGGGTCGCGCTCCTCTCTCCTGACGCCTCCGACTCCCGGTCTCCA
AAGCCAGAAGAGAAGGTTTGATTCAGCAACTGTTTGCTCCCTTTTCCTGGTCGCTCTGACCCTCTCTGGATACTGGGTTGATCCACGGAA
AAACCGAAGACGACGTTTGGGATTTAATTATTCCTCTCAGCTTTGGAATCTTTTACTTCTCACTTGGACAAGAACTCAAGAGCAGAATCT
CCGTGTTGCAATCTGGTTCCTAAGGAGGAAGAGGAAGGCAGCCCTGGAGTGGTTTCTTTACAGTAATTTCAACAGAAGAGTGAGAGATGG
AACCCGAAGAAGAAAGGATTCGTTACAGCCAGAGATTGCGTGGTACCATGCGACGACGCTATGAAGATGATGGCATTTCAGATGATGAAA
TTGAAGGAAAAAGAACTTTTGACTTGGAAGAGAAACTGCACACCAACAAATATAATGCCAATTTTGTTACTTTTATGGAAGGAAAAGATT
TTAATGTAGAGTATATTCAGCGGGGTGGCTTGAGAGATCCTCTGATTTTCAAGAATTCTGATGGACTCGGAATAAAAATGCCGGATCCAG
ACTTCACTGTGAATGATGTCAAAATGTGTGTGGGGAGTCGTCGCATGGTGGATGTCATGGACGTGAACACACAGAAAGGCATTGAAATGA
CCATGGCTCAGTGGACACGCTACTATGAGACCCCAGAGGAGGAGCGAGAGAAACTCTATAATGTCATCAGCCTCGAGTTTAGCCACACCA
GGCTGGAGAATATGGTGCAGAGGCCCTCCACGGTGGATTTCATTGACTGGGTAGACAACATGTGGCCAAGGCACTTGAAGGAAAGCCAGA
CTGAATCAACAAATGCCATCTTGGAGATGCAGTACCCTAAAGTGCAGAAGTACTGTCTAATGAGTGTTCGAGGCTGCTATACTGACTTCC
ATGTGGACTTTGGTGGTACCTCTGTTTGGTATCACATCCATCAAGGGGGAAAGAAAGGGTGAATCATGTTTAAGAAGGTCAACAGGATTG
AGCACAAGAGGAATAAGACAGAAAAACCAAAAAAGCTTAATCCATGGATTCCACGCATCTTCAACCACAAATGCTTTGTCACCTTCCTTA
CTGGCTGCTATAGTTGCCTCTGGAAATTCAGACAATGGGAAAAAACTAAAGTTGGATTTTGTTGCTGCACTTGGAAAGAGCAATTATTTT
GCCGTGCCTGGTAATTTCATTTGTCTTGTCTCTGATGTTGCTGTTCCTGTGGATAGAAACATCCAGTGAATACTTTAACTTTGACTGGGT
CACTTTTCTAGGAACAGGATACTGGTTTTTCTGGTCTATTTTTATTCTGAGTTTAGCTAGGATCCTGACTGCCTACTCTTCATTGCTGTT
GTTACTTGGATTTTTGTTGCTTTGGGAAAGGATTGAACTATACCTGCACTTGTGTCATAAGATCCTGATTCTGCTAGTGATTCTTCTGTG
TGTCATTTTAATGTTCATTATATGCAAATTCTGGAAAGAAAGGTGGCTGGTAGCTGGGCTGTCAATGCAGATCTTTGCTCCCTACGTGCA
CCTGGTCAGCATAACTGTGATGGTTATCCTTTTCTGGCCTGTGGCCTTCTACGTGGCATGTTTGGAAAGAGAAGTTAGAATGAGAAGATA
CAGGATGACACATTCTGAGAAAAAAAGACTCAAGCAATGTAATGTAATCACAAGGTTAAGAGGTCTACAAGTGCCTGTTGGATTACCCTT
TCTTCTTATCCTTTTAGGTCTCTATTTGATGCCACTGGGGATTTATTCTCCCTGCATTCAGGAGAAGGAGAATTTGGGGCCCAAGCCAAC
CATCTTTGGACATAGAGGTGCACCCATGTTGGGGCCTGAGAATACCATGATGTCCTTTGAGAAAGCTGTTGAACATGGAGCCCATGGATT
GGAGACTGATATACACTTAAGTTATGATCATGTGCCTTTCCTCATGCATGACTTTGACCTGAAAAGAACAACCAATATTGGGGAAGTTCA
GCCAGAATCTGCCTGCGAGAACCCTGCCTTCTTCAACTGGGATTTCCTATCGACTCTGAATGCAGGCAAATGGTTTGTAAAACCAGAGCT
CAGGCCATTTTACAATATGAAACCTCTATCAGAGGCAGATAAAGAAAGAGCAAGAAATCAGTCAATTCCAACACTAGCTGATTTATTGAC
ACTTGCAGAGAAGGAAAGAAAATTTGTGATATTTGATCTTCATCGCCCTCCACCAAAACATCCTCTCAGACACACATTTGTCCGCCAAGT
AGTAAGCGTGATCCTTGCCTCTAAAATCGAGCAACATCTGATTTTTTGGTTGCCAGCTCATGATAGGCAATACGTCAGGTCCGTGGCTCC
TGGTTTTCAGCATGTGGGCCGTTTAGTATCCATTGAAACCCTTGCTAAAAACAATATCAGTATAATAAATGTTGACTACAAGAAGTTGTT
CCCTAATGGGTTAAGAGATTATAAAGCAGCTAACATCCATATCAACGTATACACCGTCAATGAGCCTTGGCTTTTCTCACTGGCCTGGTG
CTCCAGGATTAACTCAGTGACCACAGACAACATTGGGCTCCTGAGTCAGCTTGATCACCCTCACTTCTTCATGACACCAAAGTTCTATGT
GTTCATGTGGCTCCTTGCAGATATCATTTCTGTGCTTTTTATTGTTGCCATATTTTGTTTTCACTGGCGGAGAGAGACTGAAAAAGAAAA
ATTGTTTGAAACCTCCAGCACTCGCACAGATACTCAGAGTGGAAGTAAGAATGAGGAAGATAGATAGATAGATAGATTTGCACATAGCCA
TGAAACCTCCTGTCCGAGTTGTGGAAGGTCCTTGGACTCTAGCAGCCCTCTACCCGGCTCTACCCAAGAGTGGAAAGGAACACCAAGGCC
ATTTCAATTTTGCAGCACCATCCAAGAAACTACTACCTATCAAGAATGCTGTCACACCTTTGAAGCCTGGCAAGCATGAGATTCAACCAC
CGATGCCCACCGTGGTCTTTGAACTCACCCAAGCACCCACCAGGCAGGCTACAAGTGAGGCTACCTTTCAAACTACATTGCCCACCCTGA
AGGTGGATAAGCCAACCATGCCCTCCATAGAGGTCCCCTATCCTTAAATAAGAGACCTCTAAGAGATCCCCATGGCTGAATACTCCAAAT
AATCCTATGTCACAATATATTCCATTGCATCTGACATAGCCTTCTGTGTTTCCAAAGAAGAATTAGCCACATCTCCCCTGCTTCTTCCTC
TCTCTGCCTAAGGGTGGTGATGGTGGGGAGTGGTTGATAAAGGCACACAGAAGGGCCACGGAGGCTCTCAGGGGAACCATTGTGCTCTCG
CTATCAAGAATGCATCTCAAGGGGCTAGGCAAGGGGAAAACTGCTGTGTGTGGTCTTGGAACTGGTTGCTGTCAGGTTTATCTCATCCTA

>In-frame_ENST00000529006_ENST00000315938_TCGA-EW-A6SC-01A_KDM2A_chr11_66983420_+_GDPD4_chr11_76998465_length(amino acids)=542AA_start in transcript=1318_stop in transcript=2946
MLLHLERAIILPCLVISFVLSLMLLFLWIETSSEYFNFDWVTFLGTGYWFFWSIFILSLARILTAYSSLLLLLGFLLLWERIELYLHLCH
KILILLVILLCVILMFIICKFWKERWLVAGLSMQIFAPYVHLVSITVMVILFWPVAFYVACLEREVRMRRYRMTHSEKKRLKQCNVITRL
RGLQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLGPKPTIFGHRGAPMLGPENTMMSFEKAVEHGAHGLETDIHLSYDHVPFLMHDFD
LKRTTNIGEVQPESACENPAFFNWDFLSTLNAGKWFVKPELRPFYNMKPLSEADKERARNQSIPTLADLLTLAEKERKFVIFDLHRPPPK
HPLRHTFVRQVVSVILASKIEQHLIFWLPAHDRQYVRSVAPGFQHVGRLVSIETLAKNNISIINVDYKKLFPNGLRDYKAANIHINVYTV
NEPWLFSLAWCSRINSVTTDNIGLLSQLDHPHFFMTPKFYVFMWLLADIISVLFIVAIFCFHWRRETEKEKLFETSSTRTDTQSGSKNEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM2A-GDPD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM2A-GDPD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM2A-GDPD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM2AC0009402Colorectal Carcinoma1CTD_human
HgeneKDM2AC0009404Colorectal Neoplasms1CTD_human
HgeneKDM2AC2931456Prostate cancer, familial1CTD_human
HgeneKDM2AC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human