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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KDM5B-ITPKB (FusionGDB2 ID:41669)

Fusion Gene Summary for KDM5B-ITPKB

check button Fusion gene summary
Fusion gene informationFusion gene name: KDM5B-ITPKB
Fusion gene ID: 41669
HgeneTgene
Gene symbol

KDM5B

ITPKB

Gene ID

10765

3707

Gene namelysine demethylase 5Binositol-trisphosphate 3-kinase B
SynonymsCT31|JARID1B|MRT65|PLU-1|PLU1|PPP1R98|PUT1|RBBP2H1A|RBP2-H1IP3-3KB|IP3K|IP3K-B|IP3KB|PIG37
Cytomap

1q32.1

1q42.12

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 5Bcancer/testis antigen 31histone demethylase JARID1Bjumonji, AT rich interactive domain 1Bjumonji/ARID domain-containing protein 1Blysine (K)-specific demethylase 5Bprotein phosphatase 1, regulatory subunit 98putative Dinositol-trisphosphate 3-kinase BIP3 3-kinase BIP3K Binositol 1,4,5-trisphosphate 3-kinase BinsP 3-kinase Bproliferation-inducing protein 37
Modification date2020032020200313
UniProtAcc

Q9UGL1

P27987

Ensembl transtripts involved in fusion geneENST00000367265, ENST00000367264, 
ENST00000456180, 		ENST00000272117, 
ENST00000429204, ENST00000366784, 
Fusion gene scores* DoF score14 X 13 X 9=163812 X 10 X 3=360
# samples 1713
** MAII scorelog2(17/1638*10)=-3.26832870550331
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KDM5B [Title/Abstract] AND ITPKB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKDM5B(202742246)-ITPKB(226836472), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM5B

GO:0034720

histone H3-K4 demethylation

20228790

TgeneITPKB

GO:0032957

inositol trisphosphate metabolic process

1654894

TgeneITPKB

GO:0071277

cellular response to calcium ion

1654894


check buttonFusion gene breakpoints across KDM5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ITPKB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-WB-A81J-01AKDM5Bchr1

202742246

-ITPKBchr1

226836472

-
ChimerDB4PCPGTCGA-WB-A81J-01AKDM5Bchr1

202742246

-ITPKBchr1

226836472

-
ChimerDB4PCPGTCGA-WB-A81J-01AKDM5Bchr1

202742246

-ITPKBchr1

226836472

-


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Fusion Gene ORF analysis for KDM5B-ITPKB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367265ENST00000272117KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
In-frameENST00000367265ENST00000429204KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
5CDS-intronENST00000367265ENST00000366784KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
In-frameENST00000367264ENST00000272117KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
In-frameENST00000367264ENST00000429204KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
5CDS-intronENST00000367264ENST00000366784KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
intron-3CDSENST00000456180ENST00000272117KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
intron-3CDSENST00000456180ENST00000429204KDM5Bchr1

202742246

-ITPKBchr1

226836472

-
intron-intronENST00000456180ENST00000366784KDM5Bchr1

202742246

-ITPKBchr1

226836472

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367265KDM5Bchr1202742246-ENST00000272117ITPKBchr1226836472-563117419342649571
ENST00000367265KDM5Bchr1202742246-ENST00000429204ITPKBchr1226836472-563117419342649571
ENST00000367264KDM5Bchr1202742246-ENST00000272117ITPKBchr1226836472-45796891131597494
ENST00000367264KDM5Bchr1202742246-ENST00000429204ITPKBchr1226836472-45796891131597494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367265ENST00000272117KDM5Bchr1202742246-ITPKBchr1226836472-0.0047552610.9952447
ENST00000367265ENST00000429204KDM5Bchr1202742246-ITPKBchr1226836472-0.0047552610.9952447
ENST00000367264ENST00000272117KDM5Bchr1202742246-ITPKBchr1226836472-0.0022426550.9977574
ENST00000367264ENST00000429204KDM5Bchr1202742246-ITPKBchr1226836472-0.0022426550.9977574

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Fusion Genomic Features for KDM5B-ITPKB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KDM5B-ITPKB


check button Go to

FGviewer for the breakpoints of chr1:202742246-chr1:226836472

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM5B

Q9UGL1

ITPKB

P27987

FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-42832_73192.01581.0DomainJmjN
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-42897_187192.01581.0DomainARID
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-42732_73192.01545.0DomainJmjN
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-42797_187192.01545.0DomainARID
TgeneITPKBchr1:202742246chr1:226836472ENST0000036678403599_6050645.0Compositional biasNote=Poly-Ser
TgeneITPKBchr1:202742246chr1:226836472ENST0000027211707730_732644.0947.0Nucleotide bindingATP
TgeneITPKBchr1:202742246chr1:226836472ENST0000036678403730_7320645.0Nucleotide bindingATP
TgeneITPKBchr1:202742246chr1:226836472ENST0000042920418730_732644.0947.0Nucleotide bindingATP
TgeneITPKBchr1:202742246chr1:226836472ENST0000027211707768_776644.0947.0RegionCalmodulin-binding
TgeneITPKBchr1:202742246chr1:226836472ENST0000027211707793_800644.0947.0RegionSubstrate binding
TgeneITPKBchr1:202742246chr1:226836472ENST0000036678403768_7760645.0RegionCalmodulin-binding
TgeneITPKBchr1:202742246chr1:226836472ENST0000036678403793_8000645.0RegionSubstrate binding
TgeneITPKBchr1:202742246chr1:226836472ENST0000042920418768_776644.0947.0RegionCalmodulin-binding
TgeneITPKBchr1:202742246chr1:226836472ENST0000042920418793_800644.0947.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-4281434_1439192.01581.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-4271434_1439192.01545.0Compositional biasNote=Poly-Lys
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-428453_619192.01581.0DomainJmjC
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-427453_619192.01545.0DomainJmjC
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-4281176_1224192.01581.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-4281484_1538192.01581.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-428309_359192.01581.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367264-428692_744192.01581.0Zinc fingerC5HC2
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-4271176_1224192.01545.0Zinc fingerPHD-type 2
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-4271484_1538192.01545.0Zinc fingerPHD-type 3
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-427309_359192.01545.0Zinc fingerPHD-type 1
HgeneKDM5Bchr1:202742246chr1:226836472ENST00000367265-427692_744192.01545.0Zinc fingerC5HC2
TgeneITPKBchr1:202742246chr1:226836472ENST0000027211707599_605644.0947.0Compositional biasNote=Poly-Ser
TgeneITPKBchr1:202742246chr1:226836472ENST0000042920418599_605644.0947.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for KDM5B-ITPKB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000367265_ENST00000272117_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(transcript)=5631nt_BP=1741nt
TTCAGTCTGTTGAAGGATACCCCGTTGTGTATTTCTACCTGTATGTACCAGAGACACCTCAAATTCAAAATGTCCAGAAATGAACACAGT
ATCTTCTTCCCTTGAGTAACTCGCCTTCTGTATATAATTGGGGTGAATGTTCCAGCAATGCCAACGGGCTAGCATCTACTCAGGCAGGTA
CGCCAGACATCTGAATCTTAATACCTCGTCGTCCCCCCTCAATCTGTCACTATGTCCTAATTTTATTTCCTACCTTTGCATCCCTTCCTC
ATAATTATCAGCACCACTGCCTTAATTTAGATCCTATCATTCCTTGTCTGGATTATTTCAAGTCTTTCGCCCCTCTCAAGTCTGACCTCG
TCATAGACTGTTTGTGGATGATTATTTTCCCTGCAACATCTCCACCTCCCAATAGTCTCCATCACTTATTAGCCATGTGAATTATGGCAA
ATTGCTTAACCTACCTATGCCTCACTTTCCTTATTGTAAAGTGGAAATAAGAGTACCTATCTCATAGGGTTGTGTGATTAATCATGCGAT
GCAATTAGAACAGTGCCTAGGATATGAAAGTGCCCCAAAATGTTACGTTATTATTATTATTACTACTATTGCCTTCTCATGAACATGCTA
TGTGTATGTTCAAGCTGTTATCTCTACTGGAAAATCCTTCTCCGTTTCCAATACTCTTTCCAAAACCCCCTCCTGGGTTTTACTGCACCT
ACCATTGTGTACTGACGTGATTGAATGATTGGCTTATGGGACTGATCCTTTCTACCAGACTTAACTTCTTCAGGGCAGGAACTCTGATAC
ATAGTAAATGGTCAATAAAAGTTGGCTCAACTGAAACCCTAAGGATAAACTCCATCCACAGCGGAAGGCGCGGCCCCGCCCGATTCGGGG
GCGGGGCGGGGAGCCGCGCGCGGAGGGTGGGTCGATGGGGGTGGGGTGGGACTCTTTTTCCTCGCCGTGGCGGCGGAGGCGCACGGCGTG
GGCTTGCGGCGAGACGTCGTCGTCGGAGGCTGAAAAAGCCCAAGGTGCTGCCGTTGCCCGTACAACTCGGACTTGCTGTTGCTCGAGCCG
CGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCCTCGCCCTTGCCCAGCCTGCGGTGATGGA
GGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGCTGGGCGAGTTCCTGCCTCCACCCGAGTG
CCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCCGGCCCATAGCCGAGCAGACTGGCATCTG
TAAGGTGCGGCCGCCGCCGGATTGGCAGCCACCATTTGCATGTGATGTTGATAAACTTCATTTTACGCCACGTATCCAGAGACTGAATGA
ATTGGAGGCCCAAACTCGTGTAAAATTGAATTTCTTGGACCAGATTGCAAAGTACTGGGAGTTACAGGGAAGTACTCTGAAAATTCCACA
TGTGGAGAGGAAGATCTTGGACTTATTTCAGCTTAATAAGTTAGTTGCAGAAGAAGGTGGATTTGCAGTTGTTTGCAAGGATAGAAAATG
GACCAAAATTGCTACCAAGATGGGGTTTGCTCCTGGCAAAGCAGTGGGCTCACATATCAGAGGGCATTATGAACGAATTCTCAACCCCTA
CAACTTATTCCTGTCCGGAGACAGCCTAAGGAGCAAATCATGGAGGAAGATAAAAAACATGGTGCACTGGTCTCCCTTCGTCATGTCCTT
CAAGAAGAAGTACCCCTGGATCCAGCTGGCAGGACACGCAGGGAGTTTCAAGGCAGCTGCCAATGGCAGGATCCTGAAGAAGCACTGTGA
GTCAGAGCAGCGCTGCCTGGACCGGCTGATGGTGGATGTGCTGAGGCCCTTCGTACCTGCCTACCATGGGGATGTGGTGAAGGACGGGGA
GCGCTACAACCAGATGGACGACCTGCTGGCCGACTTCGACTCGCCCTGTGTGATGGACTGCAAGATGGGAATCAGGACCTACCTGGAGGA
GGAGCTCACGAAGGCCCGGAAGAAGCCCAGCCTGCGGAAGGACATGTACCAGAAGATGATCGAGGTGGACCCCGAGGCCCCCACCGAGGA
GGAAAAAGCACAGCGGGCTGTGACCAAGCCACGGTACATGCAGTGGCGGGAGACCATCAGCTCCACGGCCACCCTGGGGTTCAGGATCGA
GGGAATCAAGAAAGAAGACGGCACCGTGAACCGGGACTTCAAGAAGACCAAAACGAGGGAGCAGGTCACCGAGGCCTTCAGAGAGTTCAC
TAAAGGAAACCATAACATCCTGATCGCCTATCGGGACCGGCTGAAGGCCATTCGAACCACTCTAGAAGTTTCTCCCTTCTTCAAGTGCCA
CGAGGTCATTGGCAGCTCCCTCCTCTTCATCCACGACAAGAAGGAACAGGCCAAAGTGTGGATGATCGACTTTGGGAAAACCACGCCCCT
GCCTGAGGGCCAGACCCTGCAGCATGACGTCCCCTGGCAGGAGGGGAACCGGGAGGATGGCTACCTCTCGGGGCTCAATAACCTCGTCGA
CATCCTGACCGAGATGTCCCAGGATGCCCCACTCGCCTGAGCTGCCCACGCCCTCCCTGGCCCCCGCCTGGGCCTCCTTTCCTCCTCCTG
TGCTTCCTTTCTCGTTCCTAACTTTTCCTTCACTTACACCTGACTGACCCTCCTGAACTGCACTACAAGACACTTTGTAGAAGAGGAGAT
GAGAGTTTCTAGTCATTTTCCTAACTTCAGGGCTTGGAGGTGGTGTTTGCACTGCTTTTTGTAGAGAGGGTCACCTACTAGAAGAGAAAT
GCCCAGTCTTAGAGGTGGGTCAGGTGTAGAGCTGGAGGGGGTCCCTGGCTGCTGAGGGGACCCTACCAGATGAGCCCTGCCTCTGGGAGC
CCCCTAGGAAGCACCAGCCTGGACCTACCACCTGCGGAGGCCTGCTGCCCCCTGGCGGCCAGTGCTGTTAGAGTGCTGCCAAGCACAGCC
TTATTTCTGCCGGGGCCTCCCCACCGGAGAGCCCAGGGGGCCGGCCGGGTTCCTGGTCCCTGGCTGGGAGCAGGGCTTTCTGGTAGTTGG
GGCACAAAACCATCGGGGAACCACATGTTGACTGTGAGCAAAGTGTCTTCCGATTAGCAGCCTCAGGGATGCCCTGGTGGCCTCTCCAGG
GCTGCTCAGGCAAGGCCCCCCACCCATCTGGTATGGAAACCTGCCGGCTCCAGGCCAGACCCAGGAGCCAAGAGAAGGCTGAAGCCAGCT
TGGCTGTGTTCTCTGATCTAGGCCTTCCCAGAGGAGGCGAGCAGAAGCTGTGCCACTTGGAATTGCAACCCATGAGTTCAGAAGGCACAC
TCTGCCATGCTGAGCTCCAAGGGTGCTACCAGGGGAAGATGGGATCTATAGAGTCTCTGGGCCCTGGCCCCAGGGAGGAGCACATTTTTC
TTGACCCTCACCTACCTGGTGCTAGTTGGTCAACCCTGCCTGCATACATGGGCTCCTGTCATGGGGCCCAGAGTCCCTTGCAGATATAGA
AATAGGGGAGGAGCTCAGGTCTGCGCCAGGCAGGAAGAAGGCAGGCTTCTGGCTTCCAGAGGTGCCGCGGTGGCCTCCTGGCATCATTTG
TTATTGCCTCTGAAACAAGCCTTACTGCCTGGAGGGCTTAGATTCCTGCTTCTCCAATGTAGTGTGGGTATCTTGTAGGGTATGTGGTGG
ATGCCAGGGCGTGCTCCAGGCACCTCTTCCTGAAGTCTCTGCATTTGGAGATTCGTGGAGAACCTATTTAAGCCCAATTTTAACTGAAAG
CCAGTGAGTCTGATATGGAAGGGAATGTAAAATTTGCCTGACTTCTTAAGAACAAAACCCCCAGCTCTGTGCCCCATGCTCCTTGGGGCT
TGCCACCCACTCCTTTGCTGTCAGAGGTACAGGAGCTGGGAGAGTCCAGGAGCTAGGGACACAGAGGGAGACTATGGACCAAGGTGTGTG
TGTCTGGAGGAACCACTGCCCACCCCACCACCCCGGGGTCTCTGGGGAACTGTCAACCTGCCCACGGGACATGTACATTTCCCCTTTTGT
GCTGGAAGTGTGAGTGACACTTGCTGGGGGTGGAGGGTGGGACACATGAGGATGTATAAGTACAGATTTTAAAAAAGGAAATCAACTTAC
ACTTCCTGGCTCTTGTTTAAAACAGTGGTGAGCTCCTGTGTGGGCCGACTTGCTAAAGGTCACACACGCGCCCGGTGGAGCACGAGAGAC
CTCGTGGCAGCATGTGATCTGGAAGGCAGGCAGGACGGGGGCGTTGGGGAGCCAAAGTCAACTCTGGGCCTCTGGAGCTATAGTGACTTT
TGGGCTAGAAGGGACCCTGGTGGTCTGTGCTTCAGCCATTTGCAGGGCAGGGGCATCATTAATTCAGACGTAAAGATTCTATGAATATGG
ACTGGCCAAAAGTTATCCTTACTCCATCTGTGAAAGAAGTTTGCTAAAGCAAATCATGATATGAACAAAAATTACAGGGGACCTGTTTAA
GAGAACAAAATGTTCCAAGCACTTTAGGCAGACACCAGCTGTTTGCAAACAATGTGCTAATATGCAAATGATGTGCTTATTAAAGGAGGC
CCATGGGGCCTCTTATTGGCAATACTTGGCTGTGGGTTACATTAAATATGTGAACATAGTATGAAGTAGCATCATTTTAGGGTTATTCTG
TTACTTAGGGTTTTTGTTTTCTGTTTTTTTTTTCTCTTTTTTTGTATTTACCGTGCTAGTTCTCTTCTACACCTACTCTGTCTCTCAAGC
CATTTTGCCACTCGCTTCCCTGCCATCTGGCCCTTCCCTTTGTCTCAGTGGGATAGATGGATTGTGAAATGGAATCTCCCAGAACCCCTG
CCCTGGCAGCCTGGAAGACCGTGCCTGCCCAGCCCTCGTCACCACAGGGACTCCTTGGGTCCTGGCAGTGCATGTGCCAGCAGGCAGGAC
AAACTCTGTGTACCTGTGCCCAGGTGAATGGGCGCAGGGTCCTCTTGCCCTGTCCTGCGGGGGGCCCCACGAGTTCCTGGCATTCAGCAC
TGCTTAGCATTCTCGGAAGGTTTCTTCAACTGCTTGCTTTTCCCAGGCTTGCCTTTAGTGTCATGTAAGACATTTTTAAGTTATATTTAT
TTTGTTGGGTTTTAAAATTGCACAGAACACTAAGACCGAAAGGCTGGACTCTTGTTTCTCCTTGAAAGCTTTGCCTTTGTTTTGAACTTC
CTTTCCCACTTGGTAGAAAGAGCCCAGAAGCAGCCCTGGCCCTGTAAGATGGACTCTTTCATCCTTCAGTTGTATTTAGCTTTGAGTTTC
TCTGCATCTGTCCACCCCATGTGTATATAACCCAGCCCCTGGCTCTGGGGTGGTCACCTCGTCAGTGCCTTTTGTTCTGGAGGAGAGGAC
CCCCCCCGCCTGCCGAGAGGCTCTCTTCCTGTTCTGCACCCCTCTCCCCATGGGACCTTGGAGAAAACTGAACTGTTACAAACCCCTGCA

>In-frame_ENST00000367265_ENST00000272117_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(amino acids)=571AA_start in transcript=934_stop in transcript=2649
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRS
KSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLAD
FDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNR
DFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVP

--------------------------------------------------------------
>In-frame_ENST00000367265_ENST00000429204_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(transcript)=5631nt_BP=1741nt
TTCAGTCTGTTGAAGGATACCCCGTTGTGTATTTCTACCTGTATGTACCAGAGACACCTCAAATTCAAAATGTCCAGAAATGAACACAGT
ATCTTCTTCCCTTGAGTAACTCGCCTTCTGTATATAATTGGGGTGAATGTTCCAGCAATGCCAACGGGCTAGCATCTACTCAGGCAGGTA
CGCCAGACATCTGAATCTTAATACCTCGTCGTCCCCCCTCAATCTGTCACTATGTCCTAATTTTATTTCCTACCTTTGCATCCCTTCCTC
ATAATTATCAGCACCACTGCCTTAATTTAGATCCTATCATTCCTTGTCTGGATTATTTCAAGTCTTTCGCCCCTCTCAAGTCTGACCTCG
TCATAGACTGTTTGTGGATGATTATTTTCCCTGCAACATCTCCACCTCCCAATAGTCTCCATCACTTATTAGCCATGTGAATTATGGCAA
ATTGCTTAACCTACCTATGCCTCACTTTCCTTATTGTAAAGTGGAAATAAGAGTACCTATCTCATAGGGTTGTGTGATTAATCATGCGAT
GCAATTAGAACAGTGCCTAGGATATGAAAGTGCCCCAAAATGTTACGTTATTATTATTATTACTACTATTGCCTTCTCATGAACATGCTA
TGTGTATGTTCAAGCTGTTATCTCTACTGGAAAATCCTTCTCCGTTTCCAATACTCTTTCCAAAACCCCCTCCTGGGTTTTACTGCACCT
ACCATTGTGTACTGACGTGATTGAATGATTGGCTTATGGGACTGATCCTTTCTACCAGACTTAACTTCTTCAGGGCAGGAACTCTGATAC
ATAGTAAATGGTCAATAAAAGTTGGCTCAACTGAAACCCTAAGGATAAACTCCATCCACAGCGGAAGGCGCGGCCCCGCCCGATTCGGGG
GCGGGGCGGGGAGCCGCGCGCGGAGGGTGGGTCGATGGGGGTGGGGTGGGACTCTTTTTCCTCGCCGTGGCGGCGGAGGCGCACGGCGTG
GGCTTGCGGCGAGACGTCGTCGTCGGAGGCTGAAAAAGCCCAAGGTGCTGCCGTTGCCCGTACAACTCGGACTTGCTGTTGCTCGAGCCG
CGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCCTCGCCCTTGCCCAGCCTGCGGTGATGGA
GGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGCTGGGCGAGTTCCTGCCTCCACCCGAGTG
CCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCCGGCCCATAGCCGAGCAGACTGGCATCTG
TAAGGTGCGGCCGCCGCCGGATTGGCAGCCACCATTTGCATGTGATGTTGATAAACTTCATTTTACGCCACGTATCCAGAGACTGAATGA
ATTGGAGGCCCAAACTCGTGTAAAATTGAATTTCTTGGACCAGATTGCAAAGTACTGGGAGTTACAGGGAAGTACTCTGAAAATTCCACA
TGTGGAGAGGAAGATCTTGGACTTATTTCAGCTTAATAAGTTAGTTGCAGAAGAAGGTGGATTTGCAGTTGTTTGCAAGGATAGAAAATG
GACCAAAATTGCTACCAAGATGGGGTTTGCTCCTGGCAAAGCAGTGGGCTCACATATCAGAGGGCATTATGAACGAATTCTCAACCCCTA
CAACTTATTCCTGTCCGGAGACAGCCTAAGGAGCAAATCATGGAGGAAGATAAAAAACATGGTGCACTGGTCTCCCTTCGTCATGTCCTT
CAAGAAGAAGTACCCCTGGATCCAGCTGGCAGGACACGCAGGGAGTTTCAAGGCAGCTGCCAATGGCAGGATCCTGAAGAAGCACTGTGA
GTCAGAGCAGCGCTGCCTGGACCGGCTGATGGTGGATGTGCTGAGGCCCTTCGTACCTGCCTACCATGGGGATGTGGTGAAGGACGGGGA
GCGCTACAACCAGATGGACGACCTGCTGGCCGACTTCGACTCGCCCTGTGTGATGGACTGCAAGATGGGAATCAGGACCTACCTGGAGGA
GGAGCTCACGAAGGCCCGGAAGAAGCCCAGCCTGCGGAAGGACATGTACCAGAAGATGATCGAGGTGGACCCCGAGGCCCCCACCGAGGA
GGAAAAAGCACAGCGGGCTGTGACCAAGCCACGGTACATGCAGTGGCGGGAGACCATCAGCTCCACGGCCACCCTGGGGTTCAGGATCGA
GGGAATCAAGAAAGAAGACGGCACCGTGAACCGGGACTTCAAGAAGACCAAAACGAGGGAGCAGGTCACCGAGGCCTTCAGAGAGTTCAC
TAAAGGAAACCATAACATCCTGATCGCCTATCGGGACCGGCTGAAGGCCATTCGAACCACTCTAGAAGTTTCTCCCTTCTTCAAGTGCCA
CGAGGTCATTGGCAGCTCCCTCCTCTTCATCCACGACAAGAAGGAACAGGCCAAAGTGTGGATGATCGACTTTGGGAAAACCACGCCCCT
GCCTGAGGGCCAGACCCTGCAGCATGACGTCCCCTGGCAGGAGGGGAACCGGGAGGATGGCTACCTCTCGGGGCTCAATAACCTCGTCGA
CATCCTGACCGAGATGTCCCAGGATGCCCCACTCGCCTGAGCTGCCCACGCCCTCCCTGGCCCCCGCCTGGGCCTCCTTTCCTCCTCCTG
TGCTTCCTTTCTCGTTCCTAACTTTTCCTTCACTTACACCTGACTGACCCTCCTGAACTGCACTACAAGACACTTTGTAGAAGAGGAGAT
GAGAGTTTCTAGTCATTTTCCTAACTTCAGGGCTTGGAGGTGGTGTTTGCACTGCTTTTTGTAGAGAGGGTCACCTACTAGAAGAGAAAT
GCCCAGTCTTAGAGGTGGGTCAGGTGTAGAGCTGGAGGGGGTCCCTGGCTGCTGAGGGGACCCTACCAGATGAGCCCTGCCTCTGGGAGC
CCCCTAGGAAGCACCAGCCTGGACCTACCACCTGCGGAGGCCTGCTGCCCCCTGGCGGCCAGTGCTGTTAGAGTGCTGCCAAGCACAGCC
TTATTTCTGCCGGGGCCTCCCCACCGGAGAGCCCAGGGGGCCGGCCGGGTTCCTGGTCCCTGGCTGGGAGCAGGGCTTTCTGGTAGTTGG
GGCACAAAACCATCGGGGAACCACATGTTGACTGTGAGCAAAGTGTCTTCCGATTAGCAGCCTCAGGGATGCCCTGGTGGCCTCTCCAGG
GCTGCTCAGGCAAGGCCCCCCACCCATCTGGTATGGAAACCTGCCGGCTCCAGGCCAGACCCAGGAGCCAAGAGAAGGCTGAAGCCAGCT
TGGCTGTGTTCTCTGATCTAGGCCTTCCCAGAGGAGGCGAGCAGAAGCTGTGCCACTTGGAATTGCAACCCATGAGTTCAGAAGGCACAC
TCTGCCATGCTGAGCTCCAAGGGTGCTACCAGGGGAAGATGGGATCTATAGAGTCTCTGGGCCCTGGCCCCAGGGAGGAGCACATTTTTC
TTGACCCTCACCTACCTGGTGCTAGTTGGTCAACCCTGCCTGCATACATGGGCTCCTGTCATGGGGCCCAGAGTCCCTTGCAGATATAGA
AATAGGGGAGGAGCTCAGGTCTGCGCCAGGCAGGAAGAAGGCAGGCTTCTGGCTTCCAGAGGTGCCGCGGTGGCCTCCTGGCATCATTTG
TTATTGCCTCTGAAACAAGCCTTACTGCCTGGAGGGCTTAGATTCCTGCTTCTCCAATGTAGTGTGGGTATCTTGTAGGGTATGTGGTGG
ATGCCAGGGCGTGCTCCAGGCACCTCTTCCTGAAGTCTCTGCATTTGGAGATTCGTGGAGAACCTATTTAAGCCCAATTTTAACTGAAAG
CCAGTGAGTCTGATATGGAAGGGAATGTAAAATTTGCCTGACTTCTTAAGAACAAAACCCCCAGCTCTGTGCCCCATGCTCCTTGGGGCT
TGCCACCCACTCCTTTGCTGTCAGAGGTACAGGAGCTGGGAGAGTCCAGGAGCTAGGGACACAGAGGGAGACTATGGACCAAGGTGTGTG
TGTCTGGAGGAACCACTGCCCACCCCACCACCCCGGGGTCTCTGGGGAACTGTCAACCTGCCCACGGGACATGTACATTTCCCCTTTTGT
GCTGGAAGTGTGAGTGACACTTGCTGGGGGTGGAGGGTGGGACACATGAGGATGTATAAGTACAGATTTTAAAAAAGGAAATCAACTTAC
ACTTCCTGGCTCTTGTTTAAAACAGTGGTGAGCTCCTGTGTGGGCCGACTTGCTAAAGGTCACACACGCGCCCGGTGGAGCACGAGAGAC
CTCGTGGCAGCATGTGATCTGGAAGGCAGGCAGGACGGGGGCGTTGGGGAGCCAAAGTCAACTCTGGGCCTCTGGAGCTATAGTGACTTT
TGGGCTAGAAGGGACCCTGGTGGTCTGTGCTTCAGCCATTTGCAGGGCAGGGGCATCATTAATTCAGACGTAAAGATTCTATGAATATGG
ACTGGCCAAAAGTTATCCTTACTCCATCTGTGAAAGAAGTTTGCTAAAGCAAATCATGATATGAACAAAAATTACAGGGGACCTGTTTAA
GAGAACAAAATGTTCCAAGCACTTTAGGCAGACACCAGCTGTTTGCAAACAATGTGCTAATATGCAAATGATGTGCTTATTAAAGGAGGC
CCATGGGGCCTCTTATTGGCAATACTTGGCTGTGGGTTACATTAAATATGTGAACATAGTATGAAGTAGCATCATTTTAGGGTTATTCTG
TTACTTAGGGTTTTTGTTTTCTGTTTTTTTTTTCTCTTTTTTTGTATTTACCGTGCTAGTTCTCTTCTACACCTACTCTGTCTCTCAAGC
CATTTTGCCACTCGCTTCCCTGCCATCTGGCCCTTCCCTTTGTCTCAGTGGGATAGATGGATTGTGAAATGGAATCTCCCAGAACCCCTG
CCCTGGCAGCCTGGAAGACCGTGCCTGCCCAGCCCTCGTCACCACAGGGACTCCTTGGGTCCTGGCAGTGCATGTGCCAGCAGGCAGGAC
AAACTCTGTGTACCTGTGCCCAGGTGAATGGGCGCAGGGTCCTCTTGCCCTGTCCTGCGGGGGGCCCCACGAGTTCCTGGCATTCAGCAC
TGCTTAGCATTCTCGGAAGGTTTCTTCAACTGCTTGCTTTTCCCAGGCTTGCCTTTAGTGTCATGTAAGACATTTTTAAGTTATATTTAT
TTTGTTGGGTTTTAAAATTGCACAGAACACTAAGACCGAAAGGCTGGACTCTTGTTTCTCCTTGAAAGCTTTGCCTTTGTTTTGAACTTC
CTTTCCCACTTGGTAGAAAGAGCCCAGAAGCAGCCCTGGCCCTGTAAGATGGACTCTTTCATCCTTCAGTTGTATTTAGCTTTGAGTTTC
TCTGCATCTGTCCACCCCATGTGTATATAACCCAGCCCCTGGCTCTGGGGTGGTCACCTCGTCAGTGCCTTTTGTTCTGGAGGAGAGGAC
CCCCCCCGCCTGCCGAGAGGCTCTCTTCCTGTTCTGCACCCCTCTCCCCATGGGACCTTGGAGAAAACTGAACTGTTACAAACCCCTGCA

>In-frame_ENST00000367265_ENST00000429204_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(amino acids)=571AA_start in transcript=934_stop in transcript=2649
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNF
LDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRS
KSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLAD
FDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNR
DFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVP

--------------------------------------------------------------
>In-frame_ENST00000367264_ENST00000272117_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(transcript)=4579nt_BP=689nt
CAACTCGGACTTGCTGTTGCTCGAGCCGCGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCC
TCGCCCTTGCCCAGCCTGCGGTGATGGAGGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGC
TGGGCGAGTTCCTGCCTCCACCCGAGTGCCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCC
GGCCCATAGCCGAGCAGACTGGCATCTGTAAGGTGCGGCCGCCGCCGGATTGGCAGCCACCATTTGCATGTGATGTTGATAAACTTCATT
TTACGCCACGTATCCAGAGACTGAATGAATTGGAGGCCCAAACTCGTGTAAAATTGAATTTCTTGGACCAGATTGCAAAGTACTGGGAGT
TACAGGGAAGTACTCTGAAAATTCCACATGTGGAGAGGAAGATCTTGGACTTATTTCAGCTTAATAAGTTAGTTGCAGAAGAAGGTGGAT
TTGCAGTTGTTTGCAAGGATAGAAAATGGACCAAAATTGCTACCAAGATGGGGTTTGCTCCTGGCAAAGCAGTGGGCTCACATATCAGAG
GGCATTATGAACGAATTCTCAACCCCTACAACTTATTCCTGTCCGGAGACAGCCTAAGGAGCAAATCATGGAGGAAGATAAAAAACATGG
TGCACTGGTCTCCCTTCGTCATGTCCTTCAAGAAGAAGTACCCCTGGATCCAGCTGGCAGGACACGCAGGGAGTTTCAAGGCAGCTGCCA
ATGGCAGGATCCTGAAGAAGCACTGTGAGTCAGAGCAGCGCTGCCTGGACCGGCTGATGGTGGATGTGCTGAGGCCCTTCGTACCTGCCT
ACCATGGGGATGTGGTGAAGGACGGGGAGCGCTACAACCAGATGGACGACCTGCTGGCCGACTTCGACTCGCCCTGTGTGATGGACTGCA
AGATGGGAATCAGGACCTACCTGGAGGAGGAGCTCACGAAGGCCCGGAAGAAGCCCAGCCTGCGGAAGGACATGTACCAGAAGATGATCG
AGGTGGACCCCGAGGCCCCCACCGAGGAGGAAAAAGCACAGCGGGCTGTGACCAAGCCACGGTACATGCAGTGGCGGGAGACCATCAGCT
CCACGGCCACCCTGGGGTTCAGGATCGAGGGAATCAAGAAAGAAGACGGCACCGTGAACCGGGACTTCAAGAAGACCAAAACGAGGGAGC
AGGTCACCGAGGCCTTCAGAGAGTTCACTAAAGGAAACCATAACATCCTGATCGCCTATCGGGACCGGCTGAAGGCCATTCGAACCACTC
TAGAAGTTTCTCCCTTCTTCAAGTGCCACGAGGTCATTGGCAGCTCCCTCCTCTTCATCCACGACAAGAAGGAACAGGCCAAAGTGTGGA
TGATCGACTTTGGGAAAACCACGCCCCTGCCTGAGGGCCAGACCCTGCAGCATGACGTCCCCTGGCAGGAGGGGAACCGGGAGGATGGCT
ACCTCTCGGGGCTCAATAACCTCGTCGACATCCTGACCGAGATGTCCCAGGATGCCCCACTCGCCTGAGCTGCCCACGCCCTCCCTGGCC
CCCGCCTGGGCCTCCTTTCCTCCTCCTGTGCTTCCTTTCTCGTTCCTAACTTTTCCTTCACTTACACCTGACTGACCCTCCTGAACTGCA
CTACAAGACACTTTGTAGAAGAGGAGATGAGAGTTTCTAGTCATTTTCCTAACTTCAGGGCTTGGAGGTGGTGTTTGCACTGCTTTTTGT
AGAGAGGGTCACCTACTAGAAGAGAAATGCCCAGTCTTAGAGGTGGGTCAGGTGTAGAGCTGGAGGGGGTCCCTGGCTGCTGAGGGGACC
CTACCAGATGAGCCCTGCCTCTGGGAGCCCCCTAGGAAGCACCAGCCTGGACCTACCACCTGCGGAGGCCTGCTGCCCCCTGGCGGCCAG
TGCTGTTAGAGTGCTGCCAAGCACAGCCTTATTTCTGCCGGGGCCTCCCCACCGGAGAGCCCAGGGGGCCGGCCGGGTTCCTGGTCCCTG
GCTGGGAGCAGGGCTTTCTGGTAGTTGGGGCACAAAACCATCGGGGAACCACATGTTGACTGTGAGCAAAGTGTCTTCCGATTAGCAGCC
TCAGGGATGCCCTGGTGGCCTCTCCAGGGCTGCTCAGGCAAGGCCCCCCACCCATCTGGTATGGAAACCTGCCGGCTCCAGGCCAGACCC
AGGAGCCAAGAGAAGGCTGAAGCCAGCTTGGCTGTGTTCTCTGATCTAGGCCTTCCCAGAGGAGGCGAGCAGAAGCTGTGCCACTTGGAA
TTGCAACCCATGAGTTCAGAAGGCACACTCTGCCATGCTGAGCTCCAAGGGTGCTACCAGGGGAAGATGGGATCTATAGAGTCTCTGGGC
CCTGGCCCCAGGGAGGAGCACATTTTTCTTGACCCTCACCTACCTGGTGCTAGTTGGTCAACCCTGCCTGCATACATGGGCTCCTGTCAT
GGGGCCCAGAGTCCCTTGCAGATATAGAAATAGGGGAGGAGCTCAGGTCTGCGCCAGGCAGGAAGAAGGCAGGCTTCTGGCTTCCAGAGG
TGCCGCGGTGGCCTCCTGGCATCATTTGTTATTGCCTCTGAAACAAGCCTTACTGCCTGGAGGGCTTAGATTCCTGCTTCTCCAATGTAG
TGTGGGTATCTTGTAGGGTATGTGGTGGATGCCAGGGCGTGCTCCAGGCACCTCTTCCTGAAGTCTCTGCATTTGGAGATTCGTGGAGAA
CCTATTTAAGCCCAATTTTAACTGAAAGCCAGTGAGTCTGATATGGAAGGGAATGTAAAATTTGCCTGACTTCTTAAGAACAAAACCCCC
AGCTCTGTGCCCCATGCTCCTTGGGGCTTGCCACCCACTCCTTTGCTGTCAGAGGTACAGGAGCTGGGAGAGTCCAGGAGCTAGGGACAC
AGAGGGAGACTATGGACCAAGGTGTGTGTGTCTGGAGGAACCACTGCCCACCCCACCACCCCGGGGTCTCTGGGGAACTGTCAACCTGCC
CACGGGACATGTACATTTCCCCTTTTGTGCTGGAAGTGTGAGTGACACTTGCTGGGGGTGGAGGGTGGGACACATGAGGATGTATAAGTA
CAGATTTTAAAAAAGGAAATCAACTTACACTTCCTGGCTCTTGTTTAAAACAGTGGTGAGCTCCTGTGTGGGCCGACTTGCTAAAGGTCA
CACACGCGCCCGGTGGAGCACGAGAGACCTCGTGGCAGCATGTGATCTGGAAGGCAGGCAGGACGGGGGCGTTGGGGAGCCAAAGTCAAC
TCTGGGCCTCTGGAGCTATAGTGACTTTTGGGCTAGAAGGGACCCTGGTGGTCTGTGCTTCAGCCATTTGCAGGGCAGGGGCATCATTAA
TTCAGACGTAAAGATTCTATGAATATGGACTGGCCAAAAGTTATCCTTACTCCATCTGTGAAAGAAGTTTGCTAAAGCAAATCATGATAT
GAACAAAAATTACAGGGGACCTGTTTAAGAGAACAAAATGTTCCAAGCACTTTAGGCAGACACCAGCTGTTTGCAAACAATGTGCTAATA
TGCAAATGATGTGCTTATTAAAGGAGGCCCATGGGGCCTCTTATTGGCAATACTTGGCTGTGGGTTACATTAAATATGTGAACATAGTAT
GAAGTAGCATCATTTTAGGGTTATTCTGTTACTTAGGGTTTTTGTTTTCTGTTTTTTTTTTCTCTTTTTTTGTATTTACCGTGCTAGTTC
TCTTCTACACCTACTCTGTCTCTCAAGCCATTTTGCCACTCGCTTCCCTGCCATCTGGCCCTTCCCTTTGTCTCAGTGGGATAGATGGAT
TGTGAAATGGAATCTCCCAGAACCCCTGCCCTGGCAGCCTGGAAGACCGTGCCTGCCCAGCCCTCGTCACCACAGGGACTCCTTGGGTCC
TGGCAGTGCATGTGCCAGCAGGCAGGACAAACTCTGTGTACCTGTGCCCAGGTGAATGGGCGCAGGGTCCTCTTGCCCTGTCCTGCGGGG
GGCCCCACGAGTTCCTGGCATTCAGCACTGCTTAGCATTCTCGGAAGGTTTCTTCAACTGCTTGCTTTTCCCAGGCTTGCCTTTAGTGTC
ATGTAAGACATTTTTAAGTTATATTTATTTTGTTGGGTTTTAAAATTGCACAGAACACTAAGACCGAAAGGCTGGACTCTTGTTTCTCCT
TGAAAGCTTTGCCTTTGTTTTGAACTTCCTTTCCCACTTGGTAGAAAGAGCCCAGAAGCAGCCCTGGCCCTGTAAGATGGACTCTTTCAT
CCTTCAGTTGTATTTAGCTTTGAGTTTCTCTGCATCTGTCCACCCCATGTGTATATAACCCAGCCCCTGGCTCTGGGGTGGTCACCTCGT
CAGTGCCTTTTGTTCTGGAGGAGAGGACCCCCCCCGCCTGCCGAGAGGCTCTCTTCCTGTTCTGCACCCCTCTCCCCATGGGACCTTGGA

>In-frame_ENST00000367264_ENST00000272117_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(amino acids)=494AA_start in transcript=113_stop in transcript=1597
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKD
GERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFR
IEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTT

--------------------------------------------------------------
>In-frame_ENST00000367264_ENST00000429204_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(transcript)=4579nt_BP=689nt
CAACTCGGACTTGCTGTTGCTCGAGCCGCGTCTGCACGGGTCTCGGACCGAGCGGAGCTCGCAGCCTCGGTCCCGGAGCCCACCTTCGCC
TCGCCCTTGCCCAGCCTGCGGTGATGGAGGCGGCCACCACACTGCACCCAGGCCCGCGCCCGGCGCTGCCCCTCGGGGGCCCGGGCCCGC
TGGGCGAGTTCCTGCCTCCACCCGAGTGCCCGGTCTTCGAACCCAGCTGGGAAGAGTTCGCGGACCCCTTCGCTTTCATCCACAAGATCC
GGCCCATAGCCGAGCAGACTGGCATCTGTAAGGTGCGGCCGCCGCCGGATTGGCAGCCACCATTTGCATGTGATGTTGATAAACTTCATT
TTACGCCACGTATCCAGAGACTGAATGAATTGGAGGCCCAAACTCGTGTAAAATTGAATTTCTTGGACCAGATTGCAAAGTACTGGGAGT
TACAGGGAAGTACTCTGAAAATTCCACATGTGGAGAGGAAGATCTTGGACTTATTTCAGCTTAATAAGTTAGTTGCAGAAGAAGGTGGAT
TTGCAGTTGTTTGCAAGGATAGAAAATGGACCAAAATTGCTACCAAGATGGGGTTTGCTCCTGGCAAAGCAGTGGGCTCACATATCAGAG
GGCATTATGAACGAATTCTCAACCCCTACAACTTATTCCTGTCCGGAGACAGCCTAAGGAGCAAATCATGGAGGAAGATAAAAAACATGG
TGCACTGGTCTCCCTTCGTCATGTCCTTCAAGAAGAAGTACCCCTGGATCCAGCTGGCAGGACACGCAGGGAGTTTCAAGGCAGCTGCCA
ATGGCAGGATCCTGAAGAAGCACTGTGAGTCAGAGCAGCGCTGCCTGGACCGGCTGATGGTGGATGTGCTGAGGCCCTTCGTACCTGCCT
ACCATGGGGATGTGGTGAAGGACGGGGAGCGCTACAACCAGATGGACGACCTGCTGGCCGACTTCGACTCGCCCTGTGTGATGGACTGCA
AGATGGGAATCAGGACCTACCTGGAGGAGGAGCTCACGAAGGCCCGGAAGAAGCCCAGCCTGCGGAAGGACATGTACCAGAAGATGATCG
AGGTGGACCCCGAGGCCCCCACCGAGGAGGAAAAAGCACAGCGGGCTGTGACCAAGCCACGGTACATGCAGTGGCGGGAGACCATCAGCT
CCACGGCCACCCTGGGGTTCAGGATCGAGGGAATCAAGAAAGAAGACGGCACCGTGAACCGGGACTTCAAGAAGACCAAAACGAGGGAGC
AGGTCACCGAGGCCTTCAGAGAGTTCACTAAAGGAAACCATAACATCCTGATCGCCTATCGGGACCGGCTGAAGGCCATTCGAACCACTC
TAGAAGTTTCTCCCTTCTTCAAGTGCCACGAGGTCATTGGCAGCTCCCTCCTCTTCATCCACGACAAGAAGGAACAGGCCAAAGTGTGGA
TGATCGACTTTGGGAAAACCACGCCCCTGCCTGAGGGCCAGACCCTGCAGCATGACGTCCCCTGGCAGGAGGGGAACCGGGAGGATGGCT
ACCTCTCGGGGCTCAATAACCTCGTCGACATCCTGACCGAGATGTCCCAGGATGCCCCACTCGCCTGAGCTGCCCACGCCCTCCCTGGCC
CCCGCCTGGGCCTCCTTTCCTCCTCCTGTGCTTCCTTTCTCGTTCCTAACTTTTCCTTCACTTACACCTGACTGACCCTCCTGAACTGCA
CTACAAGACACTTTGTAGAAGAGGAGATGAGAGTTTCTAGTCATTTTCCTAACTTCAGGGCTTGGAGGTGGTGTTTGCACTGCTTTTTGT
AGAGAGGGTCACCTACTAGAAGAGAAATGCCCAGTCTTAGAGGTGGGTCAGGTGTAGAGCTGGAGGGGGTCCCTGGCTGCTGAGGGGACC
CTACCAGATGAGCCCTGCCTCTGGGAGCCCCCTAGGAAGCACCAGCCTGGACCTACCACCTGCGGAGGCCTGCTGCCCCCTGGCGGCCAG
TGCTGTTAGAGTGCTGCCAAGCACAGCCTTATTTCTGCCGGGGCCTCCCCACCGGAGAGCCCAGGGGGCCGGCCGGGTTCCTGGTCCCTG
GCTGGGAGCAGGGCTTTCTGGTAGTTGGGGCACAAAACCATCGGGGAACCACATGTTGACTGTGAGCAAAGTGTCTTCCGATTAGCAGCC
TCAGGGATGCCCTGGTGGCCTCTCCAGGGCTGCTCAGGCAAGGCCCCCCACCCATCTGGTATGGAAACCTGCCGGCTCCAGGCCAGACCC
AGGAGCCAAGAGAAGGCTGAAGCCAGCTTGGCTGTGTTCTCTGATCTAGGCCTTCCCAGAGGAGGCGAGCAGAAGCTGTGCCACTTGGAA
TTGCAACCCATGAGTTCAGAAGGCACACTCTGCCATGCTGAGCTCCAAGGGTGCTACCAGGGGAAGATGGGATCTATAGAGTCTCTGGGC
CCTGGCCCCAGGGAGGAGCACATTTTTCTTGACCCTCACCTACCTGGTGCTAGTTGGTCAACCCTGCCTGCATACATGGGCTCCTGTCAT
GGGGCCCAGAGTCCCTTGCAGATATAGAAATAGGGGAGGAGCTCAGGTCTGCGCCAGGCAGGAAGAAGGCAGGCTTCTGGCTTCCAGAGG
TGCCGCGGTGGCCTCCTGGCATCATTTGTTATTGCCTCTGAAACAAGCCTTACTGCCTGGAGGGCTTAGATTCCTGCTTCTCCAATGTAG
TGTGGGTATCTTGTAGGGTATGTGGTGGATGCCAGGGCGTGCTCCAGGCACCTCTTCCTGAAGTCTCTGCATTTGGAGATTCGTGGAGAA
CCTATTTAAGCCCAATTTTAACTGAAAGCCAGTGAGTCTGATATGGAAGGGAATGTAAAATTTGCCTGACTTCTTAAGAACAAAACCCCC
AGCTCTGTGCCCCATGCTCCTTGGGGCTTGCCACCCACTCCTTTGCTGTCAGAGGTACAGGAGCTGGGAGAGTCCAGGAGCTAGGGACAC
AGAGGGAGACTATGGACCAAGGTGTGTGTGTCTGGAGGAACCACTGCCCACCCCACCACCCCGGGGTCTCTGGGGAACTGTCAACCTGCC
CACGGGACATGTACATTTCCCCTTTTGTGCTGGAAGTGTGAGTGACACTTGCTGGGGGTGGAGGGTGGGACACATGAGGATGTATAAGTA
CAGATTTTAAAAAAGGAAATCAACTTACACTTCCTGGCTCTTGTTTAAAACAGTGGTGAGCTCCTGTGTGGGCCGACTTGCTAAAGGTCA
CACACGCGCCCGGTGGAGCACGAGAGACCTCGTGGCAGCATGTGATCTGGAAGGCAGGCAGGACGGGGGCGTTGGGGAGCCAAAGTCAAC
TCTGGGCCTCTGGAGCTATAGTGACTTTTGGGCTAGAAGGGACCCTGGTGGTCTGTGCTTCAGCCATTTGCAGGGCAGGGGCATCATTAA
TTCAGACGTAAAGATTCTATGAATATGGACTGGCCAAAAGTTATCCTTACTCCATCTGTGAAAGAAGTTTGCTAAAGCAAATCATGATAT
GAACAAAAATTACAGGGGACCTGTTTAAGAGAACAAAATGTTCCAAGCACTTTAGGCAGACACCAGCTGTTTGCAAACAATGTGCTAATA
TGCAAATGATGTGCTTATTAAAGGAGGCCCATGGGGCCTCTTATTGGCAATACTTGGCTGTGGGTTACATTAAATATGTGAACATAGTAT
GAAGTAGCATCATTTTAGGGTTATTCTGTTACTTAGGGTTTTTGTTTTCTGTTTTTTTTTTCTCTTTTTTTGTATTTACCGTGCTAGTTC
TCTTCTACACCTACTCTGTCTCTCAAGCCATTTTGCCACTCGCTTCCCTGCCATCTGGCCCTTCCCTTTGTCTCAGTGGGATAGATGGAT
TGTGAAATGGAATCTCCCAGAACCCCTGCCCTGGCAGCCTGGAAGACCGTGCCTGCCCAGCCCTCGTCACCACAGGGACTCCTTGGGTCC
TGGCAGTGCATGTGCCAGCAGGCAGGACAAACTCTGTGTACCTGTGCCCAGGTGAATGGGCGCAGGGTCCTCTTGCCCTGTCCTGCGGGG
GGCCCCACGAGTTCCTGGCATTCAGCACTGCTTAGCATTCTCGGAAGGTTTCTTCAACTGCTTGCTTTTCCCAGGCTTGCCTTTAGTGTC
ATGTAAGACATTTTTAAGTTATATTTATTTTGTTGGGTTTTAAAATTGCACAGAACACTAAGACCGAAAGGCTGGACTCTTGTTTCTCCT
TGAAAGCTTTGCCTTTGTTTTGAACTTCCTTTCCCACTTGGTAGAAAGAGCCCAGAAGCAGCCCTGGCCCTGTAAGATGGACTCTTTCAT
CCTTCAGTTGTATTTAGCTTTGAGTTTCTCTGCATCTGTCCACCCCATGTGTATATAACCCAGCCCCTGGCTCTGGGGTGGTCACCTCGT
CAGTGCCTTTTGTTCTGGAGGAGAGGACCCCCCCCGCCTGCCGAGAGGCTCTCTTCCTGTTCTGCACCCCTCTCCCCATGGGACCTTGGA

>In-frame_ENST00000367264_ENST00000429204_TCGA-WB-A81J-01A_KDM5B_chr1_202742246_-_ITPKB_chr1_226836472_length(amino acids)=494AA_start in transcript=113_stop in transcript=1597
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRL
NELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKD
GERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFR
IEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KDM5B-ITPKB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KDM5B-ITPKB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KDM5B-ITPKB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKDM5BC0004352Autistic Disorder1GENOMICS_ENGLAND
HgeneKDM5BC0007102Malignant tumor of colon1CTD_human
HgeneKDM5BC0009375Colonic Neoplasms1CTD_human
HgeneKDM5BC4748219MENTAL RETARDATION, AUTOSOMAL RECESSIVE 651GENOMICS_ENGLAND