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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KHDRBS1-SERINC2 (FusionGDB2 ID:41769)

Fusion Gene Summary for KHDRBS1-SERINC2

check button Fusion gene summary
Fusion gene informationFusion gene name: KHDRBS1-SERINC2
Fusion gene ID: 41769
HgeneTgene
Gene symbol

KHDRBS1

SERINC2

Gene ID

10657

347735

Gene nameKH RNA binding domain containing, signal transduction associated 1serine incorporator 2
SynonymsSam68|p62|p68FKSG84|PRO0899|TDE2|TDE2L
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
DescriptionKH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associaserine incorporator 2tumor differentially expressed protein 2
Modification date2020032720200320
UniProtAcc

Q07666

.
Ensembl transtripts involved in fusion geneENST00000327300, ENST00000307714, 
ENST00000492989, 		ENST00000373710, 
ENST00000536859, ENST00000373709, 
ENST00000536384, ENST00000491976, 
Fusion gene scores* DoF score10 X 7 X 7=49026 X 8 X 13=2704
# samples 1127
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2704*10)=-3.32406383923135
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KHDRBS1 [Title/Abstract] AND SERINC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKHDRBS1(32497241)-SERINC2(31896540), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKHDRBS1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

24514149

HgeneKHDRBS1

GO:0007166

cell surface receptor signaling pathway

9045636

HgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

HgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

HgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532


check buttonFusion gene breakpoints across KHDRBS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SERINC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A3KW-01AKHDRBS1chr1

32497241

+SERINC2chr1

31896540

+


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Fusion Gene ORF analysis for KHDRBS1-SERINC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000327300ENST00000373710KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
In-frameENST00000327300ENST00000536859KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
In-frameENST00000327300ENST00000373709KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
In-frameENST00000327300ENST00000536384KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
5CDS-3UTRENST00000327300ENST00000491976KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000373710KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000536859KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000373709KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3CDSENST00000307714ENST00000536384KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
3UTR-3UTRENST00000307714ENST00000491976KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000373710KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000536859KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000373709KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3CDSENST00000492989ENST00000536384KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+
intron-3UTRENST00000492989ENST00000491976KHDRBS1chr1

32497241

+SERINC2chr1

31896540

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327300KHDRBS1chr132497241+ENST00000373710SERINC2chr131896540+259879152119704
ENST00000327300KHDRBS1chr132497241+ENST00000536859SERINC2chr131896540+251179152119704
ENST00000327300KHDRBS1chr132497241+ENST00000373709SERINC2chr131896540+259979152119704
ENST00000327300KHDRBS1chr132497241+ENST00000536384SERINC2chr131896540+259579152119704

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327300ENST00000373710KHDRBS1chr132497241+SERINC2chr131896540+0.0453924420.95460755
ENST00000327300ENST00000536859KHDRBS1chr132497241+SERINC2chr131896540+0.055627420.94437265
ENST00000327300ENST00000373709KHDRBS1chr132497241+SERINC2chr131896540+0.045582830.95441717
ENST00000327300ENST00000536384KHDRBS1chr132497241+SERINC2chr131896540+0.04623320.9537668

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Fusion Genomic Features for KHDRBS1-SERINC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KHDRBS1chr132497241+SERINC2chr131896539+5.45E-070.9999994
KHDRBS1chr132497241+SERINC2chr131896539+5.45E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KHDRBS1-SERINC2


check button Go to

FGviewer for the breakpoints of chr1:32497241-chr1:31896540

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KHDRBS1

Q07666

.
FUNCTION: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+3934_41208.0444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+3944_55208.0444.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+3959_89208.0444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39171_197208.0444.0DomainKH
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010131_15013.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010160_18213.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010202_22413.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010239_25613.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010268_29013.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010317_33913.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010385_40713.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000037370901040_5713.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373709010422_44413.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000037370901096_11813.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111131_15022.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111160_18222.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111202_22422.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111239_25622.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111268_29022.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111317_33922.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111385_40722.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000037371011140_5722.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000373710111422_44422.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000037371011196_11822.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010131_15017.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010160_18217.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010202_22417.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010239_25617.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010268_29017.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010317_33917.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010385_40717.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000053638401040_5717.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536384010422_44417.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000053638401096_11817.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010131_15017.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010160_18217.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010202_22417.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010239_25617.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010268_29017.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010317_33917.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010385_40717.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000053685901040_5717.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST00000536859010422_44417.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST0000053685901096_11817.0460.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39282_292208.0444.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39295_301208.0444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39302_332208.0444.0Compositional biasArg/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39334_363208.0444.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18282_2920.0405.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18295_3010.0405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18302_3320.0405.0Compositional biasArg/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18334_3630.0405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+1834_410.0405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+1844_550.0405.0Compositional biasDMA/Gly-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+1859_890.0405.0Compositional biasPro-rich
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18171_1970.0405.0DomainKH
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39100_260208.0444.0RegionInvolved in homodimerization
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18100_2600.0405.0RegionInvolved in homodimerization
TgeneSERINC2chr1:32497241chr1:31896540ENST000003737090105_2713.0456.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST000003737101115_2722.0465.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST000005363840105_2717.0460.0TransmembraneHelical
TgeneSERINC2chr1:32497241chr1:31896540ENST000005368590105_2717.0460.0TransmembraneHelical


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Fusion Gene Sequence for KHDRBS1-SERINC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000327300_ENST00000373710_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(transcript)=2598nt_BP=791nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG
GAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGG

>In-frame_ENST00000327300_ENST00000373710_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(amino acids)=704AA_start in transcript=5_stop in transcript=2119
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSA
PCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFF
TLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAW
YAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPE
QKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQ

--------------------------------------------------------------
>In-frame_ENST00000327300_ENST00000536859_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(transcript)=2511nt_BP=791nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG

>In-frame_ENST00000327300_ENST00000536859_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(amino acids)=704AA_start in transcript=5_stop in transcript=2119
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSA
PCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFF
TLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAW
YAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPE
QKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQ

--------------------------------------------------------------
>In-frame_ENST00000327300_ENST00000373709_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(transcript)=2599nt_BP=791nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG
GAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGG

>In-frame_ENST00000327300_ENST00000373709_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(amino acids)=704AA_start in transcript=5_stop in transcript=2119
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSA
PCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFF
TLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAW
YAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPE
QKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQ

--------------------------------------------------------------
>In-frame_ENST00000327300_ENST00000536384_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(transcript)=2595nt_BP=791nt
GCTGGCTGCGCACGCGCGCCGCCTCATTTCCGGTGCTCTCTCTCGCTGGGTCGCTCGGGTCGGCTTCGGTCGCTACCGCTCCCGCTCTGC
CACCCCCGCCAACCGCCGCTCGGGCCTCCGTCGCTGCCGCGTCGCTTTCTCGCTCCTTGGATCGCACATCCTCCCAGATGCAGCGCCGGG
ACGACCCCGCCGCGCGCATGAGCCGGTCTTCGGGCCGTAGCGGCTCCATGGACCCCTCCGGTGCCCACCCCTCGGTGCGTCAGACGCCGT
CTCGGCAGCCGCCGCTGCCTCACCGGTCCCGGGGAGGCGGAGGGGGATCCCGCGGGGGCGCCCGGGCCTCGCCCGCCACGCAGCCGCCAC
CGCTGCTGCCGCCCTCGGCCACGGGTCCCGACGCGACAGTGGGCGGGCCAGCGCCGACCCCGCTGCTGCCCCCCTCGGCCACAGCCTCGG
TCAAGATGGAGCCAGAGAACAAGTACCTGCCCGAACTCATGGCCGAGAAGGACTCGCTCGACCCGTCCTTCACTCACGCCATGCAGCTGC
TGACGGCAGAAATTGAGAAGATTCAGAAAGGAGACTCAAAAAAGGATGATGAGGAGAATTACTTGGATTTATTTTCTCATAAGAACATGA
AACTGAAAGAGCGAGTGCTGATACCTGTCAAGCAGTATCCCAAGTTCAATTTTGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCA
AAAGACTGCAGGAAGAGACTGGTGCAAAGATCTCTGTATTGGGAAAGGGCTCAATGAGAGACAAAGCCAAGGCGTCCTGCCTCTGCGGCT
CTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGG
TGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCA
CCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCT
TTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCC
TGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCT
TCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTG
CCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGC
CCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCC
AGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCC
CTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGG
ATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCC
TGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACG
AGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGT
ACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACC
TGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCT
GGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACC
TGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCAC
ACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGG
GAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGG

>In-frame_ENST00000327300_ENST00000536384_TCGA-EO-A3KW-01A_KHDRBS1_chr1_32497241_+_SERINC2_chr1_31896540_length(amino acids)=704AA_start in transcript=5_stop in transcript=2119
MRTRAASFPVLSLAGSLGSASVATAPALPPPPTAARASVAAASLSRSLDRTSSQMQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSR
QPPLPHRSRGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENKYLPELMAEKDSLDPSFTHAMQLLT
AEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKASCLCGSA
PCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHIDCGSLLGYRAVYRMCFATAAFFFFF
TLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAW
YAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNSGLLQASVITLYTMFVTWSALSSIPE
QKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGRAFDNEQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KHDRBS1-SERINC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39351_443208.0444.0HNRNPA1
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18351_4430.0405.0HNRNPA1
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000327300+39400_420208.0444.0ZBTB7A
HgeneKHDRBS1chr1:32497241chr1:31896540ENST00000492989+18400_4200.0405.0ZBTB7A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KHDRBS1-SERINC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KHDRBS1-SERINC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSERINC2C0001973Alcoholic Intoxication, Chronic1PSYGENET