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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA0195-NUP85 (FusionGDB2 ID:41861)

Fusion Gene Summary for KIAA0195-NUP85

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0195-NUP85
Fusion gene ID: 41861
HgeneTgene
Gene symbol

KIAA0195

NUP85

Gene ID

9772

79902

Gene nametransmembrane protein 94nucleoporin 85
SynonymsIDDCDF|KIAA0195FROUNT|NPHS17|Nup75
Cytomap

17q25.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 94nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314256, ENST00000579208, 
ENST00000375248, ENST00000583795, 
ENST00000245544, ENST00000541827, 
ENST00000579324, ENST00000449421, 
ENST00000579298, ENST00000447371, 
ENST00000540768, 
Fusion gene scores* DoF score8 X 5 X 7=2809 X 9 X 6=486
# samples 1110
** MAII scorelog2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0195 [Title/Abstract] AND NUP85 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA0195(73468010)-NUP85(73204622), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIAA0195 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUP85 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-5485KIAA0195chr17

73468010

+NUP85chr17

73204622

+
ChimerDB4LUSCTCGA-22-5485-01AKIAA0195chr17

73468010

-NUP85chr17

73204622

+


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Fusion Gene ORF analysis for KIAA0195-NUP85

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314256ENST00000245544KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000314256ENST00000541827KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000314256ENST00000579324KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000314256ENST00000449421KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000314256ENST00000579298KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-5UTRENST00000314256ENST00000447371KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000314256ENST00000540768KIAA0195chr17

73468010

+NUP85chr17

73204622

+
In-frameENST00000579208ENST00000245544KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000579208ENST00000541827KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000579208ENST00000579324KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000579208ENST00000449421KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000579208ENST00000579298KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-5UTRENST00000579208ENST00000447371KIAA0195chr17

73468010

+NUP85chr17

73204622

+
5CDS-intronENST00000579208ENST00000540768KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-3CDSENST00000375248ENST00000245544KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000375248ENST00000541827KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000375248ENST00000579324KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000375248ENST00000449421KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000375248ENST00000579298KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-5UTRENST00000375248ENST00000447371KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000375248ENST00000540768KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-3CDSENST00000583795ENST00000245544KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000583795ENST00000541827KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000583795ENST00000579324KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000583795ENST00000449421KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000583795ENST00000579298KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-5UTRENST00000583795ENST00000447371KIAA0195chr17

73468010

+NUP85chr17

73204622

+
intron-intronENST00000583795ENST00000540768KIAA0195chr17

73468010

+NUP85chr17

73204622

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314256KIAA0195chr1773468010+ENST00000245544NUP85chr1773204622+24354183762355659
ENST00000579208KIAA0195chr1773468010+ENST00000245544NUP85chr1773204622+22492321902169659

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314256ENST00000245544KIAA0195chr1773468010+NUP85chr1773204622+0.0035968960.9964031
ENST00000579208ENST00000245544KIAA0195chr1773468010+NUP85chr1773204622+0.0031542120.9968458

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Fusion Genomic Features for KIAA0195-NUP85


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIAA0195chr1773468010+NUP85chr1773204621+9.19E-060.9999908
KIAA0195chr1773468010+NUP85chr1773204621+9.19E-060.9999908

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0195-NUP85


check button Go to

FGviewer for the breakpoints of chr17:73468010-chr17:73204622

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+2321093_11138.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+2321121_11418.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+2321168_11888.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+2321229_12498.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+2321262_12828.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+2321307_13278.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+232274_2948.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+232321_3418.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+23265_858.01357.0TransmembraneHelical
HgeneKIAA0195chr17:73468010chr17:73204622ENST00000314256+23293_1138.01357.0TransmembraneHelical


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Fusion Gene Sequence for KIAA0195-NUP85


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000314256_ENST00000245544_TCGA-22-5485_KIAA0195_chr17_73468010_+_NUP85_chr17_73204622_length(transcript)=2435nt_BP=418nt
ACTCGGCACCTAATTCCGCCAGGCTCCCAGAGGGGCGGTTGCAGCTACAGCCTAGCACGCCGCGTAGCCAATAAGAAGCCAGAATTCCCC
CTATTCTCAAATCCTGACCAATCGGTGGCCTGAACTTTAGCTCTCTGGCCGGCGCCTCTGTTGCCCGGAAGGGAGGCAAGCCCCCTTAGA
GTTGCCAGTAACGGACATGGCTGCGGCCCCCGGAGGAGGGGACGTGAAGTGAGGAGGGGGTTGGGAGGGGAGAGGACGCGGGCGAGGAAG
ACCAGCCCCGGGGCCCCGATGTTGTGACTGTGACAGACTCACTGGGGTTTGTACATGCTGGGGAGGAGCCTTCCTTTCAGGGGTGACCAC
ATTCATCTGGGCATGCCTGCAGTACTCTTGGCCCATGGACCTGAAGGAGAAGCACCTGTTGATTCCAGGCGTGAATTCCAAGAAGAACCA
AATGTATTTTGACTGGGGTCCAGGGGAGATGCTGGTATGTGAAACCTCCTTCAACAAAAAAGAAAAATCAGAGATGGTGCCAAGTTGCCC
CTTTATCTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAATCTTGAGAAAACTCTTCAATGAATCCCATGGAATCTTTCTGGGCCT
CCAGAGAATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTCAATTGGTTCGAGTGAGTAAAAACTACCGATCAGTCATCAGAGCATG
TATGGAGGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGCAGCCAGGTCTCCATTTTGTCAGCAAT
GGAGCTCATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCT
CCATGTGTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCAT
CTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAAT
CATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCA
CGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGC
TGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCAT
TGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGC
CTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGA
CCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGC
TCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGAT
ACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGAT
CTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGT
GTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAG
TGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTC
CTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTT
CTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCT
CCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTC
ACTGGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAATAAATGTTGTTTTGCAA

>In-frame_ENST00000314256_ENST00000245544_TCGA-22-5485_KIAA0195_chr17_73468010_+_NUP85_chr17_73204622_length(amino acids)=659AA_start in transcript=376_stop in transcript=2355
MQYSWPMDLKEKHLLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRIDE
ELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEV
DSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECER
YLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDI
HQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTE
QKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTF
LGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTSRRPVHGESDTEQLQDDDI

--------------------------------------------------------------
>In-frame_ENST00000579208_ENST00000245544_TCGA-22-5485_KIAA0195_chr17_73468010_+_NUP85_chr17_73204622_length(transcript)=2249nt_BP=232nt
AGTAACGGACATGGCTGCGGCCCCCGGAGGAGGGGACGTGAAGTGAGGAGGGGGTTGGGAGGGGAGAGGACGCGGGCGAGGAAGACCAGC
CCCGGGGCCCCGATGTTGTGACTGTGACAGACTCACTGGGGTTTGTACATGCTGGGGAGGAGCCTTCCTTTCAGGGGTGACCACATTCAT
CTGGGCATGCCTGCAGTACTCTTGGCCCATGGACCTGAAGGAGAAGCACCTGTTGATTCCAGGCGTGAATTCCAAGAAGAACCAAATGTA
TTTTGACTGGGGTCCAGGGGAGATGCTGGTATGTGAAACCTCCTTCAACAAAAAAGAAAAATCAGAGATGGTGCCAAGTTGCCCCTTTAT
CTATATCATCCGTAAGGATGTAGATGTTTACTCTCAAATCTTGAGAAAACTCTTCAATGAATCCCATGGAATCTTTCTGGGCCTCCAGAG
AATTGACGAAGAGTTGACTGGAAAATCCAGAAAATCTCAATTGGTTCGAGTGAGTAAAAACTACCGATCAGTCATCAGAGCATGTATGGA
GGAAATGCACCAGGTTGCAATTGCTGCTAAAGATCCAGCCAATGGCCGCCAGTTCAGCAGCCAGGTCTCCATTTTGTCAGCAATGGAGCT
CATCTGGAACCTGTGTGAGATTCTTTTTATTGAAGTGGCCCCAGCTGGCCCTCTCCTCCTCCATCTCCTTGACTGGGTCCGGCTCCATGT
GTGCGAGGTGGACAGTTTGTCGGCAGATGTTCTGGGCAGTGAGAATCCAAGCAAACATGACAGCTTCTGGAACTTGGTGACCATCTTGGT
GCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGG
GGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGA
ATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTT
GTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCT
GCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGA
GTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTG
CAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCC
CAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCT
GAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGC
CATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGA
CAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCG
ACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGAT
GACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGC
AGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGA
TGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACTGGA

>In-frame_ENST00000579208_ENST00000245544_TCGA-22-5485_KIAA0195_chr17_73468010_+_NUP85_chr17_73204622_length(amino acids)=659AA_start in transcript=190_stop in transcript=2169
MQYSWPMDLKEKHLLIPGVNSKKNQMYFDWGPGEMLVCETSFNKKEKSEMVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFLGLQRIDE
ELTGKSRKSQLVRVSKNYRSVIRACMEEMHQVAIAAKDPANGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEV
DSLSADVLGSENPSKHDSFWNLVTILVLQGRLDEARQMLSKEADASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECER
YLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHYYAQSSLDLFLGGESSPEPLDNILLAAFEFDI
HQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLYFGSNMREFLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTE
QKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTF
LGKYREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLTSRRPVHGESDTEQLQDDDI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIAA0195-NUP85


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA0195-NUP85


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA0195-NUP85


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP85C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
TgeneNUP85C4748545NEPHROTIC SYNDROME, TYPE 171GENOMICS_ENGLAND;UNIPROT