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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA0232-INPP4B (FusionGDB2 ID:41869)

Fusion Gene Summary for KIAA0232-INPP4B

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0232-INPP4B
Fusion gene ID: 41869
HgeneTgene
Gene symbol

KIAA0232

INPP4B

Gene ID

9778

8821

Gene nameKIAA0232inositol polyphosphate-4-phosphatase type II B
Synonyms--
Cytomap

4p16.1

4q31.21

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein KIAA0232inositol polyphosphate 4-phosphatase type IIinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDatype II inositol 3,4-bisphosphate 4-phosphatase
Modification date2020031320200313
UniProtAcc.

O15327

Ensembl transtripts involved in fusion geneENST00000503278, ENST00000425103, 
ENST00000307659, 		ENST00000513000, 
ENST00000509777, ENST00000262992, 
ENST00000308502, ENST00000508116, 
ENST00000507861, ENST00000506217, 
ENST00000508084, 
Fusion gene scores* DoF score12 X 8 X 5=48012 X 11 X 6=792
# samples 1613
** MAII scorelog2(16/480*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0232 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA0232(6826411)-INPP4B(142950067), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIAA0232 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across INPP4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-LL-A441-01AKIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
ChimerDB4BRCATCGA-LL-A441-01AKIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
ChimerDB4BRCATCGA-LL-A441-01AKIAA0232chr4

6826411

-INPP4Bchr4

142950067

-


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Fusion Gene ORF analysis for KIAA0232-INPP4B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000503278ENST00000513000KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000509777KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000262992KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000308502KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000508116KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000507861KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000506217KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
intron-intronENST00000503278ENST00000508084KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
In-frameENST00000425103ENST00000513000KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000509777KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000262992KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000308502KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000508116KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000507861KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000506217KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000425103ENST00000508084KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
In-frameENST00000307659ENST00000513000KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000509777KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000262992KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000308502KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000508116KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000507861KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000506217KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-
5CDS-intronENST00000307659ENST00000508084KIAA0232chr4

6826411

+INPP4Bchr4

142950067

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425103KIAA0232chr46826411+ENST00000513000INPP4Bchr4142950067-636561031192724131
ENST00000307659KIAA0232chr46826411+ENST00000513000INPP4Bchr4142950067-644168631952800131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425103ENST00000513000KIAA0232chr46826411+INPP4Bchr4142950067-0.0176793170.98232067
ENST00000307659ENST00000513000KIAA0232chr46826411+INPP4Bchr4142950067-0.0178874660.9821125

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Fusion Genomic Features for KIAA0232-INPP4B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0232-INPP4B


check button Go to

FGviewer for the breakpoints of chr4:6826411-chr4:142950067

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INPP4B

O15327

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000307659+31014_2077.01396.0Compositional biasNote=Poly-Ser
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000425103+2914_2077.01396.0Compositional biasNote=Poly-Ser
TgeneINPP4Bchr4:6826411chr4:142950067ENST000005062170523_1650.0132.0DomainC2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000307659+310202_21077.01396.0Compositional biasNote=Poly-Ser
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000307659+310350_35877.01396.0Compositional biasNote=Poly-Ser
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000425103+29202_21077.01396.0Compositional biasNote=Poly-Ser
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000425103+29350_35877.01396.0Compositional biasNote=Poly-Ser
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000307659+31089_9677.01396.0Nucleotide bindingATP
HgeneKIAA0232chr4:6826411chr4:142950067ENST00000425103+2989_9677.01396.0Nucleotide bindingATP
TgeneINPP4Bchr4:6826411chr4:142950067ENST00000262992222423_165880.6666666666666925.0DomainC2
TgeneINPP4Bchr4:6826411chr4:142950067ENST00000308502212323_165880.6666666666666925.0DomainC2
TgeneINPP4Bchr4:6826411chr4:142950067ENST00000508116232523_165880.6666666666666925.0DomainC2
TgeneINPP4Bchr4:6826411chr4:142950067ENST00000513000252723_165880.6666666666666925.0DomainC2


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Fusion Gene Sequence for KIAA0232-INPP4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000425103_ENST00000513000_TCGA-LL-A441-01A_KIAA0232_chr4_6826411_+_INPP4B_chr4_142950067_length(transcript)=6365nt_BP=610nt
ACGTAAGGCGCAGGCCAGGGCCGCCCGGCGCTCGGCAGCCGCCCGCAGCCCCTCGGAGCCAGAGGAGAGGCGCCCCCGCCGGCCGCCGCG
CCGCCCGGCAGCCTCGGCAGGTTCTGCCGGAGACTTCCATTTGGCCTCAATGTGAAATTAAAGTAGAAAATCACATCTACATGCATGTTG
CTATCAGGATGTTGATTCATTAGTCATGCCTGAAGAGGGAAAGTCTGTTTTAGGTGGCTGACTACCAGCAAAAATAAATGCTTATCCTAC
ATGTCAAGCATCTCTACTTTTTACTGGAGTGAAAATCCCCTCCAGATACCAACAGAATATCAACTGCAGAAAATGCTTCACATTTTAAGG
ATGTCGGCAACCTAAATTCATGTACCCTATCTGTACAGTTGTTGTGGATGGTTTGCCATCTGAAAGCTCCTCAAGTTCTTATCCAGGCCC
TGTGTCTGTTTCTGAAATGTCTCTGCTTCATGCTTTGGGTCCAGTGCAGACCTGGCTGGGACAAGAGCTCGAGAAATGTGGCATTGATGC
CATGATTTACACTCGGTATGTCCTCAGTCTTCTGCTGCATGACAGCTATGACTACGACCTGCAGGAACAGAGAAGGATGCCGCATAGAGA
ATGTACTGAAGAATATCAAATGCAGAAAGTATGCTTTCAACATGCTACAGCTGATGGCTTTCCCCAAGTACTACAGACCTCCAGAGGGGA
CTTATGGAAAAGCTGACACCTAAGTTTACCAACATGTTAATAAACAGGAACACAAATACATTTCAGTTGGATAATCTTCACCTTGGTCTT
TTTTGTTTGTTTTTATTGTCATGAATTTGTGGTGGGGGAGATGATCACAGATGTTTCCCAAAATCTAGGAACTACTTCAATTCATCATCA
GCATATTGCTCTGAAAGAAATCCATTTTAAAAAATCTTACATGATTCAGTACTGTCATTTCTAGTTCTAAGCTTCTATGTGTTGAGCCTA
GCTGATTGAGATTGGTTCACAAAGTGTAAATTTCATTCATGAGTATTTAAATGTTTCTGAGGAAACATGGATCATTTCAATAGGACTAGG
GGTGATTCACAGAGCACCACTCTCCAACCAAATGGAAGAGAGGAGAGGGGGAAAAGGAACATATTTTTTTTGTGATACAACTTAATAGCC
TATGAGAACACAGTCAACCTGAGAATCAATGTAAGGGATTTAAAAAAAATGTGTAGCCACTCAATTAGGTAGAGTTAACTCATGATCTGG
AATACTGAGGCAGTTTGCAGGTATGTTCCACAATGATCTCTATCATCCAGTCAAGGTGTGACTCCTCCCTTGCAACAGGCATATGCATGG
AGTGAGTAAAGTGGTCAACAGACCTTTCAAAACCATGGCATCTTTTCAGAACTCTGACTTGGGTTGTGTGATCTAGCTGTGAATGTAGCA
ATATAGAACGTTTAATAGAATGATAAGCAAAACACTGCAATGATCTAAAATTACAAATAAAATAAAAATGAACAACATTTTGATACCCAA
AATGAAAATTCCCATCAGCCTGAACTTTATGTTGTGAAGTTCATGAATGTCAGTGAGGTATCTCTGAGATGTTTCTTAGCAGTCATCCTG
GTGTAAGCATGCAGTTATGGCATAGGTTTGTGTGTGTTAATAAGCCTTTAAAACATATGCAACCACAACAAATGATAAAGTAAAACAATT
ATTTTCTGTTGCCCTGAATATCAAACTTGCCCTTGCCCTTACTCAGCAAAATAACATTTATAAGTTTTCCAAAATCCCAAAGTAGAAGTT
TCCTTAAAAAAATCATCTTGTATAATACCAGTATTCAAACATGGGTAAGGTTAATCACCCCCAATCACTCAGGAGATAGTTGCAGAATTT
GAATTACAATCTCTTCTTACTTTCCTAGCCTGTGGCTTGTCACTTCTCCAAATTGCCATGCTAAATATGCATGAAAATTGAGGGAGAATG
CTAGTTAAAAAGAAATTAGGATTTATCACTGGAATTGAAACTAAGAGTACAAAAGTCTGAACGAATGAAACTTTTCTCCAAATTTTACAA
ATTCTTGTTCCTTTCTCATTAGAAGAGCATGCTATCCAAAGCATAAATCTCCCTTGAAAATAACAGAGGCTTCTTAAGCCCTCTCTTAGC
TATGATCAATGGATGATATTATGCTTCCCATAGCTAATGTGATAGCTCCTTGCCTAGGATTCCTGTTGAAATAAGGATTCTAGCCCCATG
TTAAGTTTTTCAAATTACTACAAATTTTAGATAAGCATTTGGAGCTTTTTATACTAGAATTATCAATTTTTTATTTTAGCTAATTACCTG
TGGGCATTATACTTGAGGCAGGTACCAAACTACTTACAGCCTTTTTAATGAAAATGTGCTGTGTACTTTGAATCCATTCATAGACAAAAT
TACCTTGATGTTCTCTTAACTCATTCTTTATTTTAGTGATTAAATACAACCTTTGAGTTGTTCAATATCATTTGAAAATGGTAGGATTTG
TGGTTATTTTCATTACCCTATTAGATTTAAGATAGGCTGGGATGACAGAGGCCTCCTTGAATAGCTATGAAGCCTCATTCAGCATATCAA
ATGGTAGTCTGAGTTCTAAGAAACCTTAAGTAATTTATCATTCTGTAAATACTCTTATAAGCAATAATTTTTATTTGTATTTTTGAAAAC
AAACTACTTAAATATGGAAAAATATTAACTGGAAAGCCAGCAGTAGGGTTTTCTATTTTTAAAAGACATTTCAAGGATTTCCTGTAATCC
CAGCACTTTGGGAGCCAAGGTGGATAGATCACCTGAGGTCAGGAATTGGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAA
AGATACAAAAATTAGCTGGATGTGGTGGCACACACGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATCGCTTGAACCCCGGAG
GCGGAGGTTGCAGTGAGCTGAGATCATGCCATTGCACTCCAGCCTGGGTGAAAAGAGCGAAACTCCATCTTTAAATAAGTAAATAAATGA
ATAATATAGAAGTCTCAAATTATAGTGCTTACTGTAATACAAATGCTTATGAATTTTCATTCATTACCATAGTCATCTGCATTTCCTTAT
AGAAAGCCTGTACTGGTGCAAACTTCTAAAAGTGGATTTCATCAAGAAAATGTGTTTCATAGAGACAACAATATTGCTTTTTTCCTGAGA
GGCAGTTCATTCTTAAACAACCACTTCACTATTTCTTAAGTTATTAAGGCTAAATCAAAGAGCAAATGTTAAAGTGTTTAAATCTCTCTT
GAACAAACACAGCCACAGTCATGCTATTCTATCTATATTTTCACTTAAAAGATACACCAGCAGACCTATTTTAGGAGGTCATATTGAGCC
AAAAAATGAACTGAGCAAATGACATTTCCAAACTCTTTTTTTGCTCAAAAATAATATGTTCCCCTTTGATATTAAATGCAGATATCAATT
CTGGATTAGCTATTTACTGAGCCCTAGGAAAAACATATTTAAAGACAAGGAAACCATTCATTTACATCTCATATCATTGCTTTTTGCTTT
TAAATATCGCCTTGAGGTTTGTCTACACTCTGCCAAAACAATCCCTGAACATAAGTTTGGTCAGCCTCATAATTCAGTGAGTCGAGCAAC
CATTTGTTCCAAGTGATAAATTGTACTAAATGACAAACTGCCCAATCAGGGCAGAGCTCCATGGACCCAGCCTCCAGCCCTTATTTTATA
AGACTAACCCCTCTTCTGAAAAACTCTGAAGGCTTAAAAGCTAGCATTTGGATGGAGGATACTTCCTTTTTATCCTTCAGCTATGTATGG
CACTTTACATAAAATAAGAGGTAAAAAAGGAGAGAAACTGATGTGTATAAAGTAATGCCTTTCTTCCCAAGCAAATCAAACCTCTCCCTA
TGTAAAAGTTGATAGTGTACCAAGAGACACAATACCACTGGTGGGCTGGAACTAGCTCGTTCTGATGCATAAAAGTTGATAATTAAAGTA
CCAGAAATTTTGTAAGCTAGTTGTTAAACATTACCATTATTAAATATGAAATTATAAAACACAGTGGAATACATTAAAAACCAATGTAAT
AATCAAAACATACCACTTCCCAATTATTTTACTACCTTATACTATTTATTAGTACTCTTGAGTCTATTTAGGTCTATTACATCTTTACAG
TGAAAACAGGATACAATATTGTGCTACTGTGGGTCTCTTCCTGACTGCAGATTCAGTAACATGGTGTTCGTAGCTTGAAACTGTCCACAG
TGGGAGTATTTAACACCATAGAAACTGGCTGGCAAATGCTACAAACTAGCAATTTTAATTCCTGGAAAGGCAATTGTTGAGCATTTACCA
GCACACAATGAATGCCATATTCTTTTTTTTTTATTAGGAAATAAATTATTGGAGGCAGTATAAAATTATTTAAAAAGTATCAAATGCAAT
CCCTTATCTTCAGATGGCTATAATTTTGGTTATATAAATGTTTTGGTTTTTACCTTCTTTAAAGACTCCTATTAGGTTAAAAGTCATATT
TGATGACTATATTTTATTCATAATTAAATTATTAAATCACCTTTTCTCCTGATAATGCTTTGCCAGAGAATTCTTAGCAATTCAACTGTA
GTCTAAGCAATAACTCAGGGCTAAATTCAGGGAACTGTTAGCCCAATCAGATATCACTAAAAATGTACTTCACCATCTATTTTGGAGTTT
ATAATTTTGGCATTTGCTAAAAGTAGGAAAAACAGTAACATATTACTGTGCCCAGATTCTAATAAATATAGCTCAATTGAAACCAAAACT
GTTACATTAAACAAATTACACTCTGGCACTATGCTAAATCACCACAGATGTTTTAGGTGTTTGATTTCCAAGCAGGATGGTATATCATTT
GTTTGGTTCAATATATGAGGCACCATTTGTAGTCTTTTAGGAAATAAATTAGCTTTTATCACAGATTTAGGAAACTTGTCTAAAAAAACT
GTGATCATCAGTTACAGAGGGAAGGAAACATATTGAACACAAGGCATCATAGTAGCTGGAGGCCTTAAAAATTATGCACGACCAAAAAGA
ATGATTTGGTGAGAGATGTGTAGCTGATTGACAATTTTAGTGTGAATTCATATTCATTTAACCCAGCAGCAATCTACATAAGCTATGCTT
TTTCCCACCTGTATTTATGTTTCTTAGCTTATAAAGTCCCAATATATTATATCTTTTGTTGCTTTGGCAGTTTTAATTTAGAGCTCTGCG
TTCACAGAGATGCCACCTATAGCAAAAACTATCTTTAAGAATTGGAAAATAAAATGAATGTTTTAGATAAAATATTGCAAGCCATTATGT
GTAGAGTTAATGTATGGAAATTTGCATTTGTTTTTCTGAATCATGGTGTACATTAATCACTCATTGAATTCTATTTCTAAGCAAATAAGA
GAATCAAACATTTCTAAAAGGAACATATGTCTTGCTATTAATAACAAGGAGACAGGAAAAATAGTAAGGTAATATAAGCAAAAAAAAAAA
TGTAATGAATTTAGCTATCCTAAATTGGAATTTTTACAGATTGCATGCATACTTAGAATTTTAAATTTTTAAAAGATTTACAATTGAGTA
TGGTACCCACAGAGAGTGAGTACCAAGGGAAGGAAGACCTAATACAAGTGATGTTGCCTGATAAATCACATCTTGCCAAAAAAAATATAT
TTTAGTAAATACAGTTCTTTAGGAAGAAAAATGTTGCCCTTTCACACTCACAGTGTAAATACATTCATAATATTCCTTCAATCATCTAAA
TTACCGCCAGGTCATGAAAGGACGCGATCAATGATGACCTATTGCACTCACAGGTAACATTGACTCAAATTTTGGCAATATTGCTATATT
ATCTAGATAATTCTTGTGATGTTTTTATGTCACTATCAACATTAAAAATATTTTGTTAAACAACTATGAAACTTTCAAAAGTTTGCATAT
AACTGTATGGGCACTCTCATTTCACTGCATACATACAATACTTTGTATACACATACTTCTCGTGTGGATATTTTATAATTTTATTTAATC
TAACATTTAACTTTTAGGTTTTTGTGGTACTCATCTGAAAGGTTGGCATTTGTTTTCTTTTTATGTTATATATGTATTTTAGATGAATCA
ATAATGTGTATTCCTAGAAATTTTTTCTAGGCATAAATAGATCATTTTATGTTGGCATTTAAGAGATATCATTTTTGTTTTATTGTTCTG

>In-frame_ENST00000425103_ENST00000513000_TCGA-LL-A441-01A_KIAA0232_chr4_6826411_+_INPP4B_chr4_142950067_length(amino acids)=131AA_start in transcript=3119_stop in transcript=2724
MKIHKHLYYSKHYNLRLLYYSFIYLFKDGVSLFSPRLECNGMISAHCNLRLRGSSDSLASASQVAGITRVCHHIQLIFVSLVEMGFHHVG

--------------------------------------------------------------
>In-frame_ENST00000307659_ENST00000513000_TCGA-LL-A441-01A_KIAA0232_chr4_6826411_+_INPP4B_chr4_142950067_length(transcript)=6441nt_BP=686nt
CGCAGGCCAGGGCCGCCCGGCGCTCGGCAGCCGCCCGCAGCCCCTCGGAGCCAGAGGAGAGGCGCCCCCGCCGGCCGCCGCGCCGCCCGG
CAGCCTCGGCAGGTAGTGTACACTGATAAAGGTAGGGCGCGGTGGACTCTGCCCCTGTAACCGTTCCGGAGAATGCGTTGAGAATGAAGA
CAACCAGTTCTGCCGGAGACTTCCATTTGGCCTCAATGTGAAATTAAAGTAGAAAATCACATCTACATGCATGTTGCTATCAGGATGTTG
ATTCATTAGTCATGCCTGAAGAGGGAAAGTCTGTTTTAGGTGGCTGACTACCAGCAAAAATAAATGCTTATCCTACATGTCAAGCATCTC
TACTTTTTACTGGAGTGAAAATCCCCTCCAGATACCAACAGAATATCAACTGCAGAAAATGCTTCACATTTTAAGGATGTCGGCAACCTA
AATTCATGTACCCTATCTGTACAGTTGTTGTGGATGGTTTGCCATCTGAAAGCTCCTCAAGTTCTTATCCAGGCCCTGTGTCTGTTTCTG
AAATGTCTCTGCTTCATGCTTTGGGTCCAGTGCAGACCTGGCTGGGACAAGAGCTCGAGAAATGTGGCATTGATGCCATGATTTACACTC
GGTATGTCCTCAGTCTTCTGCTGCATGACAGCTATGACTACGACCTGCAGGAACAGAGAAGGATGCCGCATAGAGAATGTACTGAAGAAT
ATCAAATGCAGAAAGTATGCTTTCAACATGCTACAGCTGATGGCTTTCCCCAAGTACTACAGACCTCCAGAGGGGACTTATGGAAAAGCT
GACACCTAAGTTTACCAACATGTTAATAAACAGGAACACAAATACATTTCAGTTGGATAATCTTCACCTTGGTCTTTTTTGTTTGTTTTT
ATTGTCATGAATTTGTGGTGGGGGAGATGATCACAGATGTTTCCCAAAATCTAGGAACTACTTCAATTCATCATCAGCATATTGCTCTGA
AAGAAATCCATTTTAAAAAATCTTACATGATTCAGTACTGTCATTTCTAGTTCTAAGCTTCTATGTGTTGAGCCTAGCTGATTGAGATTG
GTTCACAAAGTGTAAATTTCATTCATGAGTATTTAAATGTTTCTGAGGAAACATGGATCATTTCAATAGGACTAGGGGTGATTCACAGAG
CACCACTCTCCAACCAAATGGAAGAGAGGAGAGGGGGAAAAGGAACATATTTTTTTTGTGATACAACTTAATAGCCTATGAGAACACAGT
CAACCTGAGAATCAATGTAAGGGATTTAAAAAAAATGTGTAGCCACTCAATTAGGTAGAGTTAACTCATGATCTGGAATACTGAGGCAGT
TTGCAGGTATGTTCCACAATGATCTCTATCATCCAGTCAAGGTGTGACTCCTCCCTTGCAACAGGCATATGCATGGAGTGAGTAAAGTGG
TCAACAGACCTTTCAAAACCATGGCATCTTTTCAGAACTCTGACTTGGGTTGTGTGATCTAGCTGTGAATGTAGCAATATAGAACGTTTA
ATAGAATGATAAGCAAAACACTGCAATGATCTAAAATTACAAATAAAATAAAAATGAACAACATTTTGATACCCAAAATGAAAATTCCCA
TCAGCCTGAACTTTATGTTGTGAAGTTCATGAATGTCAGTGAGGTATCTCTGAGATGTTTCTTAGCAGTCATCCTGGTGTAAGCATGCAG
TTATGGCATAGGTTTGTGTGTGTTAATAAGCCTTTAAAACATATGCAACCACAACAAATGATAAAGTAAAACAATTATTTTCTGTTGCCC
TGAATATCAAACTTGCCCTTGCCCTTACTCAGCAAAATAACATTTATAAGTTTTCCAAAATCCCAAAGTAGAAGTTTCCTTAAAAAAATC
ATCTTGTATAATACCAGTATTCAAACATGGGTAAGGTTAATCACCCCCAATCACTCAGGAGATAGTTGCAGAATTTGAATTACAATCTCT
TCTTACTTTCCTAGCCTGTGGCTTGTCACTTCTCCAAATTGCCATGCTAAATATGCATGAAAATTGAGGGAGAATGCTAGTTAAAAAGAA
ATTAGGATTTATCACTGGAATTGAAACTAAGAGTACAAAAGTCTGAACGAATGAAACTTTTCTCCAAATTTTACAAATTCTTGTTCCTTT
CTCATTAGAAGAGCATGCTATCCAAAGCATAAATCTCCCTTGAAAATAACAGAGGCTTCTTAAGCCCTCTCTTAGCTATGATCAATGGAT
GATATTATGCTTCCCATAGCTAATGTGATAGCTCCTTGCCTAGGATTCCTGTTGAAATAAGGATTCTAGCCCCATGTTAAGTTTTTCAAA
TTACTACAAATTTTAGATAAGCATTTGGAGCTTTTTATACTAGAATTATCAATTTTTTATTTTAGCTAATTACCTGTGGGCATTATACTT
GAGGCAGGTACCAAACTACTTACAGCCTTTTTAATGAAAATGTGCTGTGTACTTTGAATCCATTCATAGACAAAATTACCTTGATGTTCT
CTTAACTCATTCTTTATTTTAGTGATTAAATACAACCTTTGAGTTGTTCAATATCATTTGAAAATGGTAGGATTTGTGGTTATTTTCATT
ACCCTATTAGATTTAAGATAGGCTGGGATGACAGAGGCCTCCTTGAATAGCTATGAAGCCTCATTCAGCATATCAAATGGTAGTCTGAGT
TCTAAGAAACCTTAAGTAATTTATCATTCTGTAAATACTCTTATAAGCAATAATTTTTATTTGTATTTTTGAAAACAAACTACTTAAATA
TGGAAAAATATTAACTGGAAAGCCAGCAGTAGGGTTTTCTATTTTTAAAAGACATTTCAAGGATTTCCTGTAATCCCAGCACTTTGGGAG
CCAAGGTGGATAGATCACCTGAGGTCAGGAATTGGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAGATACAAAAATTA
GCTGGATGTGGTGGCACACACGTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATCGCTTGAACCCCGGAGGCGGAGGTTGCAGT
GAGCTGAGATCATGCCATTGCACTCCAGCCTGGGTGAAAAGAGCGAAACTCCATCTTTAAATAAGTAAATAAATGAATAATATAGAAGTC
TCAAATTATAGTGCTTACTGTAATACAAATGCTTATGAATTTTCATTCATTACCATAGTCATCTGCATTTCCTTATAGAAAGCCTGTACT
GGTGCAAACTTCTAAAAGTGGATTTCATCAAGAAAATGTGTTTCATAGAGACAACAATATTGCTTTTTTCCTGAGAGGCAGTTCATTCTT
AAACAACCACTTCACTATTTCTTAAGTTATTAAGGCTAAATCAAAGAGCAAATGTTAAAGTGTTTAAATCTCTCTTGAACAAACACAGCC
ACAGTCATGCTATTCTATCTATATTTTCACTTAAAAGATACACCAGCAGACCTATTTTAGGAGGTCATATTGAGCCAAAAAATGAACTGA
GCAAATGACATTTCCAAACTCTTTTTTTGCTCAAAAATAATATGTTCCCCTTTGATATTAAATGCAGATATCAATTCTGGATTAGCTATT
TACTGAGCCCTAGGAAAAACATATTTAAAGACAAGGAAACCATTCATTTACATCTCATATCATTGCTTTTTGCTTTTAAATATCGCCTTG
AGGTTTGTCTACACTCTGCCAAAACAATCCCTGAACATAAGTTTGGTCAGCCTCATAATTCAGTGAGTCGAGCAACCATTTGTTCCAAGT
GATAAATTGTACTAAATGACAAACTGCCCAATCAGGGCAGAGCTCCATGGACCCAGCCTCCAGCCCTTATTTTATAAGACTAACCCCTCT
TCTGAAAAACTCTGAAGGCTTAAAAGCTAGCATTTGGATGGAGGATACTTCCTTTTTATCCTTCAGCTATGTATGGCACTTTACATAAAA
TAAGAGGTAAAAAAGGAGAGAAACTGATGTGTATAAAGTAATGCCTTTCTTCCCAAGCAAATCAAACCTCTCCCTATGTAAAAGTTGATA
GTGTACCAAGAGACACAATACCACTGGTGGGCTGGAACTAGCTCGTTCTGATGCATAAAAGTTGATAATTAAAGTACCAGAAATTTTGTA
AGCTAGTTGTTAAACATTACCATTATTAAATATGAAATTATAAAACACAGTGGAATACATTAAAAACCAATGTAATAATCAAAACATACC
ACTTCCCAATTATTTTACTACCTTATACTATTTATTAGTACTCTTGAGTCTATTTAGGTCTATTACATCTTTACAGTGAAAACAGGATAC
AATATTGTGCTACTGTGGGTCTCTTCCTGACTGCAGATTCAGTAACATGGTGTTCGTAGCTTGAAACTGTCCACAGTGGGAGTATTTAAC
ACCATAGAAACTGGCTGGCAAATGCTACAAACTAGCAATTTTAATTCCTGGAAAGGCAATTGTTGAGCATTTACCAGCACACAATGAATG
CCATATTCTTTTTTTTTTATTAGGAAATAAATTATTGGAGGCAGTATAAAATTATTTAAAAAGTATCAAATGCAATCCCTTATCTTCAGA
TGGCTATAATTTTGGTTATATAAATGTTTTGGTTTTTACCTTCTTTAAAGACTCCTATTAGGTTAAAAGTCATATTTGATGACTATATTT
TATTCATAATTAAATTATTAAATCACCTTTTCTCCTGATAATGCTTTGCCAGAGAATTCTTAGCAATTCAACTGTAGTCTAAGCAATAAC
TCAGGGCTAAATTCAGGGAACTGTTAGCCCAATCAGATATCACTAAAAATGTACTTCACCATCTATTTTGGAGTTTATAATTTTGGCATT
TGCTAAAAGTAGGAAAAACAGTAACATATTACTGTGCCCAGATTCTAATAAATATAGCTCAATTGAAACCAAAACTGTTACATTAAACAA
ATTACACTCTGGCACTATGCTAAATCACCACAGATGTTTTAGGTGTTTGATTTCCAAGCAGGATGGTATATCATTTGTTTGGTTCAATAT
ATGAGGCACCATTTGTAGTCTTTTAGGAAATAAATTAGCTTTTATCACAGATTTAGGAAACTTGTCTAAAAAAACTGTGATCATCAGTTA
CAGAGGGAAGGAAACATATTGAACACAAGGCATCATAGTAGCTGGAGGCCTTAAAAATTATGCACGACCAAAAAGAATGATTTGGTGAGA
GATGTGTAGCTGATTGACAATTTTAGTGTGAATTCATATTCATTTAACCCAGCAGCAATCTACATAAGCTATGCTTTTTCCCACCTGTAT
TTATGTTTCTTAGCTTATAAAGTCCCAATATATTATATCTTTTGTTGCTTTGGCAGTTTTAATTTAGAGCTCTGCGTTCACAGAGATGCC
ACCTATAGCAAAAACTATCTTTAAGAATTGGAAAATAAAATGAATGTTTTAGATAAAATATTGCAAGCCATTATGTGTAGAGTTAATGTA
TGGAAATTTGCATTTGTTTTTCTGAATCATGGTGTACATTAATCACTCATTGAATTCTATTTCTAAGCAAATAAGAGAATCAAACATTTC
TAAAAGGAACATATGTCTTGCTATTAATAACAAGGAGACAGGAAAAATAGTAAGGTAATATAAGCAAAAAAAAAAATGTAATGAATTTAG
CTATCCTAAATTGGAATTTTTACAGATTGCATGCATACTTAGAATTTTAAATTTTTAAAAGATTTACAATTGAGTATGGTACCCACAGAG
AGTGAGTACCAAGGGAAGGAAGACCTAATACAAGTGATGTTGCCTGATAAATCACATCTTGCCAAAAAAAATATATTTTAGTAAATACAG
TTCTTTAGGAAGAAAAATGTTGCCCTTTCACACTCACAGTGTAAATACATTCATAATATTCCTTCAATCATCTAAATTACCGCCAGGTCA
TGAAAGGACGCGATCAATGATGACCTATTGCACTCACAGGTAACATTGACTCAAATTTTGGCAATATTGCTATATTATCTAGATAATTCT
TGTGATGTTTTTATGTCACTATCAACATTAAAAATATTTTGTTAAACAACTATGAAACTTTCAAAAGTTTGCATATAACTGTATGGGCAC
TCTCATTTCACTGCATACATACAATACTTTGTATACACATACTTCTCGTGTGGATATTTTATAATTTTATTTAATCTAACATTTAACTTT
TAGGTTTTTGTGGTACTCATCTGAAAGGTTGGCATTTGTTTTCTTTTTATGTTATATATGTATTTTAGATGAATCAATAATGTGTATTCC
TAGAAATTTTTTCTAGGCATAAATAGATCATTTTATGTTGGCATTTAAGAGATATCATTTTTGTTTTATTGTTCTGTGTAAACCATATTC

>In-frame_ENST00000307659_ENST00000513000_TCGA-LL-A441-01A_KIAA0232_chr4_6826411_+_INPP4B_chr4_142950067_length(amino acids)=131AA_start in transcript=3195_stop in transcript=2800
MKIHKHLYYSKHYNLRLLYYSFIYLFKDGVSLFSPRLECNGMISAHCNLRLRGSSDSLASASQVAGITRVCHHIQLIFVSLVEMGFHHVG

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Fusion Gene PPI Analysis for KIAA0232-INPP4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA0232-INPP4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA0232-INPP4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneINPP4BC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneINPP4BC0005695Bladder Neoplasm1CTD_human
TgeneINPP4BC0007134Renal Cell Carcinoma1CTD_human
TgeneINPP4BC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneINPP4BC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneINPP4BC0235974Pancreatic carcinoma1CTD_human
TgeneINPP4BC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneINPP4BC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneINPP4BC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneINPP4BC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneINPP4BC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneINPP4BC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneINPP4BC2239176Liver carcinoma1CTD_human