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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIAA0753-RSBN1L (FusionGDB2 ID:41975)

Fusion Gene Summary for KIAA0753-RSBN1L

check button Fusion gene summary
Fusion gene informationFusion gene name: KIAA0753-RSBN1L
Fusion gene ID: 41975
HgeneTgene
Gene symbol

KIAA0753

RSBN1L

Gene ID

9851

222194

Gene nameKIAA0753round spermatid basic protein 1 like
SynonymsMNR|OFIP-
Cytomap

17p13.1

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein moonrakerOFD1 and FOPNL interacting proteinlysine-specific demethylase RSBN1Lround spermatid basic protein 1-like protein
Modification date2020031320200313
UniProtAcc

Q2KHM9

.
Ensembl transtripts involved in fusion geneENST00000361413, ENST00000542606, 
ENST00000572370, ENST00000589033, 
ENST00000575027, 		ENST00000334955, 
ENST00000445288, 
Fusion gene scores* DoF score8 X 7 X 5=2806 X 9 X 9=486
# samples 817
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/486*10)=-1.51542156746808
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIAA0753 [Title/Abstract] AND RSBN1L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIAA0753(6493098)-RSBN1L(77407654), # samples:2
Anticipated loss of major functional domain due to fusion event.KIAA0753-RSBN1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIAA0753 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RSBN1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-AA4GKIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
ChimerDB4ESCATCGA-VR-AA4GKIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+


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Fusion Gene ORF analysis for KIAA0753-RSBN1L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361413ENST00000334955KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
Frame-shiftENST00000361413ENST00000445288KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
Frame-shiftENST00000542606ENST00000334955KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
Frame-shiftENST00000542606ENST00000445288KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
In-frameENST00000572370ENST00000334955KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
In-frameENST00000572370ENST00000445288KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
Frame-shiftENST00000589033ENST00000334955KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
Frame-shiftENST00000589033ENST00000445288KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
intron-3CDSENST00000575027ENST00000334955KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+
intron-3CDSENST00000575027ENST00000445288KIAA0753chr17

6493098

-RSBN1Lchr7

77407654

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000572370KIAA0753chr176493098-ENST00000334955RSBN1Lchr777407654+738927878323534900
ENST00000572370KIAA0753chr176493098-ENST00000445288RSBN1Lchr777407654+404927878323534900

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572370ENST00000334955KIAA0753chr176493098-RSBN1Lchr777407654+0.0001837240.99981636
ENST00000572370ENST00000445288KIAA0753chr176493098-RSBN1Lchr777407654+0.0013010940.99869883

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Fusion Genomic Features for KIAA0753-RSBN1L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIAA0753chr176493098-RSBN1Lchr777407654+0.0003099040.9996902
KIAA0753chr176493098-RSBN1Lchr777407654+0.0003099040.9996902

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIAA0753-RSBN1L


check button Go to

FGviewer for the breakpoints of chr17:6493098-chr7:77407654

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIAA0753

Q2KHM9

.
FUNCTION: Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806). {ECO:0000269|PubMed:26297806}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0753chr17:6493098chr7:77407654ENST00000361413-1819616_642928.6666666666666968.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0753chr17:6493098chr7:77407654ENST00000542606-1617616_642629.6666666666666669.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA0753chr17:6493098chr7:77407654ENST00000572370-1718616_642629.6666666666666669.0Coiled coilOntology_term=ECO:0000255
HgeneKIAA0753chr17:6493098chr7:77407654ENST00000361413-1819885_967928.6666666666666968.0RegionNecessary and sufficient for CEP20-binding
HgeneKIAA0753chr17:6493098chr7:77407654ENST00000542606-1617885_967629.6666666666666669.0RegionNecessary and sufficient for CEP20-binding
HgeneKIAA0753chr17:6493098chr7:77407654ENST00000572370-1718885_967629.6666666666666669.0RegionNecessary and sufficient for CEP20-binding
TgeneRSBN1Lchr17:6493098chr7:77407654ENST000003349555812_15597.6666666666666847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr17:6493098chr7:77407654ENST0000033495558146_155597.6666666666666847.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr17:6493098chr7:77407654ENST0000033495558197_274597.6666666666666847.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr17:6493098chr7:77407654ENST000003349555876_121597.6666666666666847.0Compositional biasNote=Ser-rich
TgeneRSBN1Lchr17:6493098chr7:77407654ENST000004452885812_15327.6666666666667577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr17:6493098chr7:77407654ENST0000044528858146_155327.6666666666667577.0Compositional biasNote=Poly-Ala
TgeneRSBN1Lchr17:6493098chr7:77407654ENST0000044528858197_274327.6666666666667577.0Compositional biasNote=Lys-rich
TgeneRSBN1Lchr17:6493098chr7:77407654ENST000004452885876_121327.6666666666667577.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for KIAA0753-RSBN1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000572370_ENST00000334955_TCGA-VR-AA4G_KIAA0753_chr17_6493098_-_RSBN1L_chr7_77407654_length(transcript)=7389nt_BP=2787nt
AGGCGGCCGGAAGCGCGGCCTTGTTGGGGGCCCCCGTTGCCCGCCTCCCAGTAGCCGCGCCTCACCCTAGGCCAGAACCAGCTGCAGTTT
AATAGGAATGTTCCTACACATTCAAGCAACTTGGCGATCCGATATTCTTGCCCACATGCCATTAGAATTGAAAAACTGAAGCACTCATAC
AATGAATCATACCATTGTAAAGATGCAGATTGTAGAGTTGGTCCTGACCTGGGCAGTTCTGTTTCATTTTCCGTCATATCCCAAGAGAGA
CTTAGCTATGCTGTCCACCTAGCCAGAAGAGATGTGAAACGAAGACAATTTGAAAAACATATAAAAGAACATCATCTCAGAAGTCAGCCT
CAAAGCTCTCAGAAGTGTGGACATACTAAGTATAAAATACCCGACCACAGGGTGGAAAGGAAGGAATCAAAGAGTCAAGCAGCCTGTCAG
TGTAGCCACCAGCCATCCAAAGTAGAAATCTCCAGCTCTGGTGCCAAAGTATACCTTTACTCATCTCATCCAGGCCAGTCAGATCTTACT
GTGCCAAATTCGCCACCCACCCATGATCCGGGACTTCAGCCTCATCCCAGGATAGGTGACCACAAAAACATAAGTGAACAGAAAAGCCTG
CTAGAAGTCCAGCGACTCCAGAAAGAACTGAGCAGTTGTATCCACAAAATTGAAGAGGTAACTAAAAAAGATAGACTAGAAGAAGCTTTG
GATCCAGATGAAGAACGTCGAATCCGTATCAGGAGACAGGAGCAAGCTGCTCGCTCTGCCCGAATGCTCTACGTCCTCCAGCAGCAGTGA
CTTGAATTAATAATGGTTATATTTGGACAAGAGGAGATATATCGATGCATCCTTTTCTACAAAAAAGATCAATGGAAAGTCATGGGCAAT
GTCTAAGCTGGCGGCTGCCCATCGAGGAGCCATTCGGGCCTTACAGATGTTTGTCACTCAGTTTACTGACCGAGGGGAGCATCCACTTCC
TGCTCGGTGTAAGGAACTGGGCAGCCTTATTCGCCAGCTTTCACTTTGTTCTGTCAAGCTGGATGCAGACCCTTCTGTTCCTGATGTGGT
TATAGATATTCTGCAACAAATTGAGGCTTTGGAATCTCTCCTGGAAAAGAAACTGTCACCAAAAAAGGTGAAAAAATGTTTCAGTGAAAT
TCGGAGCAGATTTCCTATCGGTAGCCAAAAGGCCTTGGAGAGATGGCCAAGTACATCACCAAAGGGTGAGAGGAGGCCCCTCACAGCAAA
GGACACATTCCCACAGGAAACAAGTCGACCTTCTGTAGCAAAGCAGCTTCTTGCCGATAAGTATCAGCCCGATACGGAGCTTCCGGAGAC
CCAGAGGTTGCAGAGTGAGCTTGATGTATTAGATGCGGATATAGTTCTGGAAGAAGGACCATTTATTCTAGACCAAAGTGCAAGCTTCAA
AGACGAGGTGTTAGCCGTGGCAAAAACAAAAGCAGGGAAAAAGAAGCCTGTGACTGAGAATGTGCCGTTTAGGAAGAAAGATACTCTGGC
GCCAGCAAGACAGCAAGGACTCCGCAAAGCTGAAAGAGGTAGACAAAGCCAACCTCACAGTAAAAGCAGAGTGCAGCAGACAACAGTTTC
ATCCAGATTAAAAATGAACCGGCAGCCTGTGAAAGACCGCAAGGCACCATGGATACCCCCAAACCCCACATCCCCACCAGCGTCTCCTAA
ATGTGCTGCATGGCTAAAGGTGAAAACTAGCCCCAGAGATGCCACAAAAGAGCCTCTCCAGCAAGAAGATCCTCAAGAGGAAAGTCACCT
GACAGGTGCTGTTGAGCATGAAGCAGCCAGGCTCGCTTGGCTTGATGCTGAAACTTCCAAAAGATTGAAGGAACTAGAAGAGTTAAAAGC
CAAGGAAATTGACAGCATGCAAAAACAGAGGCTTGATTGGCTTGATGCTGAAACTTCTAGAAGAACAAAGGAACTGAATGAGCTCAAAGC
TGAAGAAATGTATAGACTCCAACAATTGAGTGTTTCTGCCACCCACTTAGCAGACAAGGTAGAGGAGGCAGTTCTGGATCGTTTGAAGCC
TCTCTTGGTCAAGGCCCAGAGAGTCAATTCTACTACAGAAGCAAATATTCATTTGAAAGATGGCTCGTCAGTAAACACAGCGAAAGCCCA
GCCTGCACAGGAGGTTGCAGCTGTTGATTTTGAATCCAACAACATTCGTCAGCTTGATGATTTTTTGGAAGATTGTGCCAGTGAGCTCTG
GGCTGTGACTCATGCTAAGATCTTGGGGTCTGAAACCTTAGCCACCGTTGAGGACAGCAAGGATAGCCCAGATCTGGAGATCATGATGCG
CCGAATGGAAGAGATGGAAAAATACCAGGAGTCTGTTCGTCAAAGATATAATAAAATCGCATATGCTGATCCTCGACTTTGGATGCAGGA
AGAAAACAATGACCAAAAAATCTCAGCAATAAGTGAAAAGCCTCTATCTCCTCATCCAATCAGAATCACGAAGACAGTGGATCGCAAGGA
TCCAGCCGTGAACATCATGTTAGAAAGGCCCTGTAATGGCAATTCCCTGGATGAAAGTGTGGGAACAGAGGAAGGATCAGAGAAAAGAGA
GGCCCCTCTTCTCTCCCTAGCCGAAGATTCTCAACAGAAAGAAGGCCGAGCTCCCCTCTTTGTCCCACCGGGTATGCAGCACAGCATCGG
TGACTACTGTAGTCGTTTTGAGCAGTACCTTCGGATCATATCTCATGAGGCTGTAGGCTCCTTCAACCCGTGGCTGATAGCTGAAAGGCC
TGATCAACCCCGTATAACCAAAGATGTAATTTGTTTTCATGCTGAAGATTTCTTAGAAGTAGTTCAACGAATGCAGTTAGATTTACATGA
ACCTCCACTGTCCCAGTGTGTCCAATGGGTTGATGATGCAAAACTGAATCAACTGAGGAGGGAAGGCATTCGCTATGCCAGGATTCAGCT
ATATGATAATGACATTTATTTTATTCCAAGGAATGTTGTTCATCAGTTCAAGACAGTTTCAGCTGTATGCAGTTTAGCATGGCATATTCG
GCTCAAATTATATCACTCAGAGGAGGACACTTCTCAGAATACAGCTACTCATGAAACAGGCACATCATCAGATTCCACATCATCTGTTCT
TGGACCTCACACTGACAACATGATTTGTGCTGTAAGCAAAGCCTCCTTGGATTCTGTTTTTTCAGATAAACTTCATTCTAAATATGAATT
ACAGCAGATTAAACATGAACCTATTGCATCTGTAAGAATCAAGGAAGAACCTGTGAATGTTAATATTCCTGAAAAGACTACAGCACTGAA
TAATATGGATGGCAAGAATGTTAAAGCAAAATTGGATCATGTTCAATTTGCAGAATTTAAGATTGACATGGATTCTAAATTTGAAAATAG
CAACAAAGATTTAAAGGAAGAATTGTGCCCTGGAAATCTAAGTCTAGTTGATACAAGGCAACACAGTTCAGCACATTCAAATCAAGATAA
AAAAGACGATGACATTTTGTGCTAAATTTGCATATACCATCTAAAATCCTTTTTTAAAAAAATTTAATGTAATAAAGATTCATGAATTCT
GAAAGCAAGCCAAGGACTTGCTCCTATGTCTGTTACAAAACATAGTTTATGTAGCTTTGTAACATTCCTCAGTGCCTGTCCATAACTGTG
AAGTATTAAGCACTTAGGGCCAGATGCACTGTAAACATTGCAGGTTTAAACATAAAGGAGTCTTTAAAAAAAAATCATTTACGTTGGAAT
TTTAGGTTTTAGAATAGAGCTGACATTAACATATATATATATATATAAATATATATATATATTTTGTAATATGAGCCAGAATTCTTTTTC
AACAATTTAAAGCTTTTCCATAGAGCTTATTTATATCCTTTTTTTTCATTTTAAATGTGTCAGCACTGTAGTGTAAATAGCTTTTAAATA
TCTTTTTAGTGTGATTTATACTGAAATGTGAGCCACTTAATAAAGGTTCATATGTTCATATTAATAAATATGTTTTCTGTTGAGTCTGTA
AAGACAAACTGACAATTCATTTAAGTCATTTGATAATGATTCTCTGCTGGTATATCTATTTAGTGTGGTATTGTAGTGCAAATGTACGTA
ATTCAAATCTAGTAAATATTTAAGTTCCTCACACTGTGCAGGCTTTTTTTTTTTTTTCTTTTTTTCTTTTTTTTGATACGGAGTTTCATT
CTGTCACCAGGCTGGAGTTCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCTCTCGGGTTCAAGTGATTATTCTCCTGCCTCAGCCT
CCTGAGTAGCTGGGACTACAGGCACGCACCACAACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCATCATGTTGGCCAGG
ATGGTCTTGATCTCTTGACCTTGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGGATTGCAGGGGTGAGCCACAGCGCCCAGCCTATG
CAGGCATTTTTAACAACCAAGACTCAGTTAAGAAAGTGTGCATCTGCGTGTGTGTGAATGTGTATATATATGTATATATATATCATATTT
TGCATAATTTTCTTAAATTGCTGAATAAGATCAATATGTGAAATTCCTTAGCCCTTCTCCCCAAAATACATTGAAAAAAGTTTTATATTA
AACTATTAAGAAAGCAGTTTAGGTAATAGAAACAGTTTTAGAAAGTTGGGAGAAACAAGGTATGTTAATGATAACAAAGGCTTCTAACTA
ATAGTTACGTGGCCAGATTACATAGCCTACCATAGATTTTTTTTATTGTGTATGGGATGATAAGAAGTTTAGAGAATTTTCTTACTAGTA
AGTACCTTTACTAAGTAATAGCTAAGTATAAAATCTTTAGTTACAGAAAGCTTGTGAGCAATTAAAATCCTTTTACATTTTTCTTGCAGA
ATGGGAGAAAAATATGGCAAATACAAAACTGTAAAATAAGGGCAATGACAATGACTCAACTGCCATATAGAGATATAATTAACAAAATAC
TTTGTGGTACCTCTTATCTCTCAGGATCTCCTCCCTACCCTAGCAAGGCAAACAACTTGGAGTACTTCCTTTTCGAAAGAAGTTCTAGAA
ATTAAATTGAGGTAGGAGACGGATTGACAGTGCCTAACTAAAGATGAGTAAAACAGACCTCTTTAATGATAGACTCACTATTTGACACTG
CTTCTACTATTGTAATTAAAAATCAGAAGTCTTTGATGTATGCGTTGCTGTAAGAAACTCTGCTCATTGCAAATCTATTTTGTTTGTTTT
TGGTATTATTCTGGGCACATACTTTGGTTGATGACTTTCAATTGGGGTTCTTTGTGCTGCCTTTTGGGTTACTGTTGGTATTTCCATTTC
TGGCTTAATTTATGGTAACCATCAAAACTGCTTATATTTCTGGTTAGGGCGAAGCCATTTAGGAAGAAGCATTTCACCAGAACAAGTAAA
AGTTAATTGCAGCAATGATGTCAGTTTTGGCCCCTAGTTTAATAAAAGGATAGGCAAATATCATAGGAAATCTTCATGGTTTGTAGGAAA
TCAGTGTTTGCAACGTAGGAAGTTTCATGGGATAGGGAAGGTATAAATCAAGATAGTAAGGGTTTTGTTTTATATGTCATTGTCTTACCA
TGCTCCCCACCTATTTAATCTTCTGTTTTAAGCTAAATTTATGGATTTGCACCTACCTTTTTGAGTGGCAGAAGTTCTTAACAAACCAGT
ATTGAGAAATAAGAAGGGATGTAGTTAAAATGGTTTTCTGTTTCTCTTTAAAGTTGAAGAATGATATATTTAACAAGAGTTGTGTTTTAT
TTCCAGTTTTCCAGTAGCATATATGTAGATGCATTGAGGTCATACTGTGAGAAAATGTCTTTAGGGTATCCCTCCAAAATAGGAGCCTTA
AACTTTTTAACTTAAAGGAAGGCATATCTAAAAACCATAGTGGTTGCTTTTAGGTATAGTTTCCTATATAACCTATAGTCAGACTTATCT
ATAATATGAAAATTTAATTGTTTTAAAAATGCATACATCGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTAGGGAGGCCGAG
GCGGGCGGATCACGAGGTCAGAAGTTTGAGACCAGTCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGTTGG
GCGTGGTGGCGTGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATTGCTTGAACCCGGGAGGAGAAGGTTGCAGTGAGCC
GAGATCGCCCCACTGCCCTCCAGCCTGGGCGACAGTCTCAAAAAAAAAAAAAAAAAAAAGCATACATCTCTGAAGGTAAAGTATAAATCA
GTGGGCTCAAGATTTGCAGGTACAGCCTTGTTAATGCCTTCAATAATGCTTACGTTCCTTGTCTTATGGGTTATAATTTTCACATCCTCT
TCAGATACAATCTGAGAACTTGTTGACTACCTTTGTTACATGCAAAAATTTTCTATTTTAATATTGCATTATATTAATGGTTTCATAGTA
CATTCCAGTTCTTTATCTGAATACAAGCGTTTTGCTTTTATTTCCAGTTTCTTGGACCAGAACAATAAAATACATAAGACATCGTTTCTA
TATGGTCATATACTATATAGAATAAAGAATTGTTATGTAAATTATTAAATGAGTATACAGACCTTTACATAAAAACTAAGGTACCTCAGT
GGAATCTGCTACAGTGCTTCCCCCTCCCTACCCCTCCATTTTGTTTATAACCTTTTAGCTATCTAAATAATACGTATTCCATACTCAGGA
TAGCTGGTTAGCTAGCAAAAGAATTAACATTTGTGATATTTACTTGCAAACTTTACTGAAGCCATATTCATTATCTTCCTTGTCACCAAG
GCTGTTGACCTTAAATAAACATTAAGTTGATTTTGCACAACACTGTATTTGTGTGTGTGCATGTGCCTGTTTTTGTGTGTGTATGTTTGT
GGGAAATAATTATGTTTGTTTCCGCATATATTCATTTTTAATGCATTCTGTAACTTTTCTCGAGTGGTGGTCATTGAGGGTAGGGAAGAT
TTTATTTTTTAAGTTGTCGTTAAGGTATTTCATTAGTGTTCCTGAGTGTAAAACAGTTTTTTCCCAAATACTTATGGCAGATAAGAGCAT
TTTTGTAAATAATAAACTAGCACCGTTTGGGTAAATTTGCATTATTTTTTGGACAGGTTCATTGTCATGTAAAACAAATATCTCAAAATT
CATTTTACATTTAGCAAAGGTGCAACATTTGTTTTTGGAGTTTGAGAGATATTTTCCTTGTCTTCCATCATTCAATAAATACTAAAATTG

>In-frame_ENST00000572370_ENST00000334955_TCGA-VR-AA4G_KIAA0753_chr17_6493098_-_RSBN1L_chr7_77407654_length(amino acids)=900AA_start in transcript=832_stop in transcript=3534
MDKRRYIDASFSTKKINGKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI
EALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSEL
DVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNR
QPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQ
KQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAA
VDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKI
SAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFE
QYLRIISHEAVGSFNPWLIAERPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYF
IPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEP
IASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDTRQHSSAHSNQDKKDDDILC

--------------------------------------------------------------
>In-frame_ENST00000572370_ENST00000445288_TCGA-VR-AA4G_KIAA0753_chr17_6493098_-_RSBN1L_chr7_77407654_length(transcript)=4049nt_BP=2787nt
AGGCGGCCGGAAGCGCGGCCTTGTTGGGGGCCCCCGTTGCCCGCCTCCCAGTAGCCGCGCCTCACCCTAGGCCAGAACCAGCTGCAGTTT
AATAGGAATGTTCCTACACATTCAAGCAACTTGGCGATCCGATATTCTTGCCCACATGCCATTAGAATTGAAAAACTGAAGCACTCATAC
AATGAATCATACCATTGTAAAGATGCAGATTGTAGAGTTGGTCCTGACCTGGGCAGTTCTGTTTCATTTTCCGTCATATCCCAAGAGAGA
CTTAGCTATGCTGTCCACCTAGCCAGAAGAGATGTGAAACGAAGACAATTTGAAAAACATATAAAAGAACATCATCTCAGAAGTCAGCCT
CAAAGCTCTCAGAAGTGTGGACATACTAAGTATAAAATACCCGACCACAGGGTGGAAAGGAAGGAATCAAAGAGTCAAGCAGCCTGTCAG
TGTAGCCACCAGCCATCCAAAGTAGAAATCTCCAGCTCTGGTGCCAAAGTATACCTTTACTCATCTCATCCAGGCCAGTCAGATCTTACT
GTGCCAAATTCGCCACCCACCCATGATCCGGGACTTCAGCCTCATCCCAGGATAGGTGACCACAAAAACATAAGTGAACAGAAAAGCCTG
CTAGAAGTCCAGCGACTCCAGAAAGAACTGAGCAGTTGTATCCACAAAATTGAAGAGGTAACTAAAAAAGATAGACTAGAAGAAGCTTTG
GATCCAGATGAAGAACGTCGAATCCGTATCAGGAGACAGGAGCAAGCTGCTCGCTCTGCCCGAATGCTCTACGTCCTCCAGCAGCAGTGA
CTTGAATTAATAATGGTTATATTTGGACAAGAGGAGATATATCGATGCATCCTTTTCTACAAAAAAGATCAATGGAAAGTCATGGGCAAT
GTCTAAGCTGGCGGCTGCCCATCGAGGAGCCATTCGGGCCTTACAGATGTTTGTCACTCAGTTTACTGACCGAGGGGAGCATCCACTTCC
TGCTCGGTGTAAGGAACTGGGCAGCCTTATTCGCCAGCTTTCACTTTGTTCTGTCAAGCTGGATGCAGACCCTTCTGTTCCTGATGTGGT
TATAGATATTCTGCAACAAATTGAGGCTTTGGAATCTCTCCTGGAAAAGAAACTGTCACCAAAAAAGGTGAAAAAATGTTTCAGTGAAAT
TCGGAGCAGATTTCCTATCGGTAGCCAAAAGGCCTTGGAGAGATGGCCAAGTACATCACCAAAGGGTGAGAGGAGGCCCCTCACAGCAAA
GGACACATTCCCACAGGAAACAAGTCGACCTTCTGTAGCAAAGCAGCTTCTTGCCGATAAGTATCAGCCCGATACGGAGCTTCCGGAGAC
CCAGAGGTTGCAGAGTGAGCTTGATGTATTAGATGCGGATATAGTTCTGGAAGAAGGACCATTTATTCTAGACCAAAGTGCAAGCTTCAA
AGACGAGGTGTTAGCCGTGGCAAAAACAAAAGCAGGGAAAAAGAAGCCTGTGACTGAGAATGTGCCGTTTAGGAAGAAAGATACTCTGGC
GCCAGCAAGACAGCAAGGACTCCGCAAAGCTGAAAGAGGTAGACAAAGCCAACCTCACAGTAAAAGCAGAGTGCAGCAGACAACAGTTTC
ATCCAGATTAAAAATGAACCGGCAGCCTGTGAAAGACCGCAAGGCACCATGGATACCCCCAAACCCCACATCCCCACCAGCGTCTCCTAA
ATGTGCTGCATGGCTAAAGGTGAAAACTAGCCCCAGAGATGCCACAAAAGAGCCTCTCCAGCAAGAAGATCCTCAAGAGGAAAGTCACCT
GACAGGTGCTGTTGAGCATGAAGCAGCCAGGCTCGCTTGGCTTGATGCTGAAACTTCCAAAAGATTGAAGGAACTAGAAGAGTTAAAAGC
CAAGGAAATTGACAGCATGCAAAAACAGAGGCTTGATTGGCTTGATGCTGAAACTTCTAGAAGAACAAAGGAACTGAATGAGCTCAAAGC
TGAAGAAATGTATAGACTCCAACAATTGAGTGTTTCTGCCACCCACTTAGCAGACAAGGTAGAGGAGGCAGTTCTGGATCGTTTGAAGCC
TCTCTTGGTCAAGGCCCAGAGAGTCAATTCTACTACAGAAGCAAATATTCATTTGAAAGATGGCTCGTCAGTAAACACAGCGAAAGCCCA
GCCTGCACAGGAGGTTGCAGCTGTTGATTTTGAATCCAACAACATTCGTCAGCTTGATGATTTTTTGGAAGATTGTGCCAGTGAGCTCTG
GGCTGTGACTCATGCTAAGATCTTGGGGTCTGAAACCTTAGCCACCGTTGAGGACAGCAAGGATAGCCCAGATCTGGAGATCATGATGCG
CCGAATGGAAGAGATGGAAAAATACCAGGAGTCTGTTCGTCAAAGATATAATAAAATCGCATATGCTGATCCTCGACTTTGGATGCAGGA
AGAAAACAATGACCAAAAAATCTCAGCAATAAGTGAAAAGCCTCTATCTCCTCATCCAATCAGAATCACGAAGACAGTGGATCGCAAGGA
TCCAGCCGTGAACATCATGTTAGAAAGGCCCTGTAATGGCAATTCCCTGGATGAAAGTGTGGGAACAGAGGAAGGATCAGAGAAAAGAGA
GGCCCCTCTTCTCTCCCTAGCCGAAGATTCTCAACAGAAAGAAGGCCGAGCTCCCCTCTTTGTCCCACCGGGTATGCAGCACAGCATCGG
TGACTACTGTAGTCGTTTTGAGCAGTACCTTCGGATCATATCTCATGAGGCTGTAGGCTCCTTCAACCCGTGGCTGATAGCTGAAAGGCC
TGATCAACCCCGTATAACCAAAGATGTAATTTGTTTTCATGCTGAAGATTTCTTAGAAGTAGTTCAACGAATGCAGTTAGATTTACATGA
ACCTCCACTGTCCCAGTGTGTCCAATGGGTTGATGATGCAAAACTGAATCAACTGAGGAGGGAAGGCATTCGCTATGCCAGGATTCAGCT
ATATGATAATGACATTTATTTTATTCCAAGGAATGTTGTTCATCAGTTCAAGACAGTTTCAGCTGTATGCAGTTTAGCATGGCATATTCG
GCTCAAATTATATCACTCAGAGGAGGACACTTCTCAGAATACAGCTACTCATGAAACAGGCACATCATCAGATTCCACATCATCTGTTCT
TGGACCTCACACTGACAACATGATTTGTGCTGTAAGCAAAGCCTCCTTGGATTCTGTTTTTTCAGATAAACTTCATTCTAAATATGAATT
ACAGCAGATTAAACATGAACCTATTGCATCTGTAAGAATCAAGGAAGAACCTGTGAATGTTAATATTCCTGAAAAGACTACAGCACTGAA
TAATATGGATGGCAAGAATGTTAAAGCAAAATTGGATCATGTTCAATTTGCAGAATTTAAGATTGACATGGATTCTAAATTTGAAAATAG
CAACAAAGATTTAAAGGAAGAATTGTGCCCTGGAAATCTAAGTCTAGTTGATACAAGGCAACACAGTTCAGCACATTCAAATCAAGATAA
AAAAGACGATGACATTTTGTGCTAAATTTGCATATACCATCTAAAATCCTTTTTTAAAAAAATTTAATGTAATAAAGATTCATGAATTCT
GAAAGCAAGCCAAGGACTTGCTCCTATGTCTGTTACAAAACATAGTTTATGTAGCTTTGTAACATTCCTCAGTGCCTGTCCATAACTGTG
AAGTATTAAGCACTTAGGGCCAGATGCACTGTAAACATTGCAGGTTTAAACATAAAGGAGTCTTTAAAAAAAAATCATTTACGTTGGAAT
TTTAGGTTTTAGAATAGAGCTGACATTAACATATATATATATATATAAATATATATATATATTTTGTAATATGAGCCAGAATTCTTTTTC
AACAATTTAAAGCTTTTCCATAGAGCTTATTTATATCCTTTTTTTTCATTTTAAATGTGTCAGCACTGTAGTGTAAATAGCTTTTAAATA

>In-frame_ENST00000572370_ENST00000445288_TCGA-VR-AA4G_KIAA0753_chr17_6493098_-_RSBN1L_chr7_77407654_length(amino acids)=900AA_start in transcript=832_stop in transcript=3534
MDKRRYIDASFSTKKINGKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQI
EALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSEL
DVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNR
QPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQ
KQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAA
VDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKI
SAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFE
QYLRIISHEAVGSFNPWLIAERPDQPRITKDVICFHAEDFLEVVQRMQLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYF
IPRNVVHQFKTVSAVCSLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFSDKLHSKYELQQIKHEP
IASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEFKIDMDSKFENSNKDLKEELCPGNLSLVDTRQHSSAHSNQDKKDDDILC

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Fusion Gene PPI Analysis for KIAA0753-RSBN1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIAA0753-RSBN1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIAA0753-RSBN1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIAA0753C0431399Familial aplasia of the vermis2GENOMICS_ENGLAND
HgeneKIAA0753C4310701OROFACIODIGITAL SYNDROME XV2CTD_human;GENOMICS_ENGLAND
HgeneKIAA0753C2745997OROFACIODIGITAL SYNDROME VI1ORPHANET