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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIDINS220-PINX1 (FusionGDB2 ID:42321)

Fusion Gene Summary for KIDINS220-PINX1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIDINS220-PINX1
Fusion gene ID: 42321
HgeneTgene
Gene symbol

KIDINS220

PINX1

Gene ID

57498

54984

Gene namekinase D interacting substrate 220PIN2 (TERF1) interacting telomerase inhibitor 1
SynonymsARMS|SINOGno1|LPTL|LPTS|Pxr1
Cytomap

2p25.1

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionkinase D-interacting substrate of 220 kDaankyrin repeat-rich membrane-spanning proteinkinase D-interacting substrate 220kDaPIN2/TERF1-interacting telomerase inhibitor 167-11-3 proteinPIN2-interacting protein 1TRF1-interacting protein 1hepatocellular carcinoma-related putative tumor suppressorliver-related putative tumor suppressorpin2-interacting protein X1protein 67-1
Modification date2020031320200327
UniProtAcc

Q9ULH0

.
Ensembl transtripts involved in fusion geneENST00000418530, ENST00000256707, 
ENST00000427284, ENST00000473731, 
ENST00000319688, ENST00000436566, 
ENST00000314787, ENST00000426190, 
ENST00000519088, ENST00000520018, 
Fusion gene scores* DoF score13 X 11 X 9=12876 X 4 X 5=120
# samples 116
** MAII scorelog2(11/1287*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIDINS220 [Title/Abstract] AND PINX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIDINS220(8890242)-PINX1(10692285), # samples:1
Anticipated loss of major functional domain due to fusion event.KIDINS220-PINX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KIDINS220-PINX1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
KIDINS220-PINX1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePINX1

GO:0007004

telomere maintenance via telomerase

11701125

TgenePINX1

GO:0010972

negative regulation of G2/M transition of mitotic cell cycle

11701125

TgenePINX1

GO:0032211

negative regulation of telomere maintenance via telomerase

11701125

TgenePINX1

GO:0051974

negative regulation of telomerase activity

11701125

TgenePINX1

GO:1902570

protein localization to nucleolus

24415760

TgenePINX1

GO:1904744

positive regulation of telomeric DNA binding

19265708|24415760

TgenePINX1

GO:1904751

positive regulation of protein localization to nucleolus

19265708


check buttonFusion gene breakpoints across KIDINS220 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PINX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C6-01AKIDINS220chr2

8890242

-PINX1chr8

10692285

-


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Fusion Gene ORF analysis for KIDINS220-PINX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000418530ENST00000314787KIDINS220chr2

8890242

-PINX1chr8

10692285

-
In-frameENST00000418530ENST00000426190KIDINS220chr2

8890242

-PINX1chr8

10692285

-
In-frameENST00000418530ENST00000519088KIDINS220chr2

8890242

-PINX1chr8

10692285

-
5CDS-5UTRENST00000418530ENST00000520018KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000256707ENST00000314787KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000256707ENST00000426190KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000256707ENST00000519088KIDINS220chr2

8890242

-PINX1chr8

10692285

-
5CDS-5UTRENST00000256707ENST00000520018KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000427284ENST00000314787KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000427284ENST00000426190KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000427284ENST00000519088KIDINS220chr2

8890242

-PINX1chr8

10692285

-
5CDS-5UTRENST00000427284ENST00000520018KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000473731ENST00000314787KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000473731ENST00000426190KIDINS220chr2

8890242

-PINX1chr8

10692285

-
Frame-shiftENST00000473731ENST00000519088KIDINS220chr2

8890242

-PINX1chr8

10692285

-
5CDS-5UTRENST00000473731ENST00000520018KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-3CDSENST00000319688ENST00000314787KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-3CDSENST00000319688ENST00000426190KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-3CDSENST00000319688ENST00000519088KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-5UTRENST00000319688ENST00000520018KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-3CDSENST00000436566ENST00000314787KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-3CDSENST00000436566ENST00000426190KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-3CDSENST00000436566ENST00000519088KIDINS220chr2

8890242

-PINX1chr8

10692285

-
intron-5UTRENST00000436566ENST00000520018KIDINS220chr2

8890242

-PINX1chr8

10692285

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418530KIDINS220chr28890242-ENST00000314787PINX1chr810692285-5002359616436791171
ENST00000418530KIDINS220chr28890242-ENST00000426190PINX1chr810692285-4923359616436791171
ENST00000418530KIDINS220chr28890242-ENST00000519088PINX1chr810692285-4729359616436791171

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418530ENST00000314787KIDINS220chr28890242-PINX1chr810692285-0.0002035130.99979645
ENST00000418530ENST00000426190KIDINS220chr28890242-PINX1chr810692285-0.0002063130.9997937
ENST00000418530ENST00000519088KIDINS220chr28890242-PINX1chr810692285-0.0002446750.9997553

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Fusion Genomic Features for KIDINS220-PINX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIDINS220-PINX1


check button Go to

FGviewer for the breakpoints of chr2:8890242-chr8:10692285

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIDINS220

Q9ULH0

.
FUNCTION: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430440_9531138.01772.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428440_9531096.01673.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429440_9531138.01753.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429440_9531138.01753.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430103_1321138.01772.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430136_1651138.01772.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430169_1981138.01772.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430202_2311138.01772.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430235_2641138.01772.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430268_2971138.01772.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430301_3301138.01772.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430334_3631138.01772.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430367_3961138.01772.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-243037_661138.01772.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-24304_331138.01772.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-243070_991138.01772.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428103_1321096.01673.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428136_1651096.01673.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428169_1981096.01673.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428202_2311096.01673.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428235_2641096.01673.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428268_2971096.01673.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428301_3301096.01673.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428334_3631096.01673.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428367_3961096.01673.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-242837_661096.01673.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-24284_331096.01673.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-242870_991096.01673.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429103_1321138.01753.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429136_1651138.01753.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429169_1981138.01753.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429202_2311138.01753.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429235_2641138.01753.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429268_2971138.01753.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429301_3301138.01753.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429334_3631138.01753.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429367_3961138.01753.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-242937_661138.01753.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-24294_331138.01753.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-242970_991138.01753.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429103_1321138.01753.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429136_1651138.01753.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429169_1981138.01753.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429202_2311138.01753.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429235_2641138.01753.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429268_2971138.01753.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429301_3301138.01753.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429334_3631138.01753.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429367_3961138.01753.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-242937_661138.01753.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-24294_331138.01753.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-242970_991138.01753.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-24301_4991138.01772.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430521_5241138.01772.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430546_6591138.01772.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430681_6851138.01772.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-24281_4991096.01673.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428521_5241096.01673.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428546_6591096.01673.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428681_6851096.01673.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-24291_4991138.01753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429521_5241138.01753.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429546_6591138.01753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429681_6851138.01753.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-24291_4991138.01753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429521_5241138.01753.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429546_6591138.01753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429681_6851138.01753.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430500_5201138.01772.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430525_5451138.01772.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430660_6801138.01772.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430686_7061138.01772.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428500_5201096.01673.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428525_5451096.01673.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428660_6801096.01673.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428686_7061096.01673.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429500_5201138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429525_5451138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429660_6801138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429686_7061138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429500_5201138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429525_5451138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429660_6801138.01753.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429686_7061138.01753.0TransmembraneHelical
TgenePINX1chr2:8890242chr8:10692285ENST000003147870726_726.333333333333333329.0DomainG-patch
TgenePINX1chr2:8890242chr8:10692285ENST000005190880626_726.333333333333333175.0DomainG-patch
TgenePINX1chr2:8890242chr8:10692285ENST0000031478707287_2976.333333333333333329.0MotifNote=TBM
TgenePINX1chr2:8890242chr8:10692285ENST0000051908806287_2976.333333333333333175.0MotifNote=TBM
TgenePINX1chr2:8890242chr8:10692285ENST0000031478707254_3286.333333333333333329.0RegionNote=Telomerase inhibitory domain (TID)
TgenePINX1chr2:8890242chr8:10692285ENST0000051908806254_3286.333333333333333175.0RegionNote=Telomerase inhibitory domain (TID)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123440_95301032.0DomainNote=KAP NTPase
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-24301766_17711138.01772.0MotifPDZ-binding
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-1231766_177101032.0MotifPDZ-binding
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-24281766_17711096.01673.0MotifPDZ-binding
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-24291766_17711138.01753.0MotifPDZ-binding
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-24291766_17711138.01753.0MotifPDZ-binding
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123103_13201032.0RepeatNote=ANK 4
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123136_16501032.0RepeatNote=ANK 5
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123169_19801032.0RepeatNote=ANK 6
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123202_23101032.0RepeatNote=ANK 7
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123235_26401032.0RepeatNote=ANK 8
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123268_29701032.0RepeatNote=ANK 9
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123301_33001032.0RepeatNote=ANK 10
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123334_36301032.0RepeatNote=ANK 11
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123367_39601032.0RepeatNote=ANK 12
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-12337_6601032.0RepeatNote=ANK 2
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-1234_3301032.0RepeatNote=ANK 1
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-12370_9901032.0RepeatNote=ANK 3
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000256707-2430707_17711138.01772.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-1231_49901032.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123521_52401032.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123546_65901032.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123681_68501032.0Topological domainExtracellular
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123707_177101032.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000418530-2428707_17711096.01673.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000427284-2429707_17711138.01753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000473731-2429707_17711138.01753.0Topological domainCytoplasmic
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123500_52001032.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123525_54501032.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123660_68001032.0TransmembraneHelical
HgeneKIDINS220chr2:8890242chr8:10692285ENST00000319688-123686_70601032.0TransmembraneHelical


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Fusion Gene Sequence for KIDINS220-PINX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000418530_ENST00000314787_TCGA-X6-A8C6-01A_KIDINS220_chr2_8890242_-_PINX1_chr8_10692285_length(transcript)=5002nt_BP=3596nt
ACGTGATCTGTCAGTTCGCGGAGAGGGAAGAATATGGCCGCCGGGTGTGGTGAGGGCGACGCGCTTGCAGTCGCCGTCTCTTGCTTCCCC
GTCCTCTGACATCGCCTGCAGCCGAGCGGGCCCGTTCCGCCGGAGCTGAGGACCAGGTATTCAAATAAAGTTAATTGCAGCTTTCTGTGA
AAATGTCAGTTTTGATATCACAGAGCGTCATAAATTATGTAGAGGAAGAAAACATTCCTGCTCTGAAAGCTCTTCTTGAAAAATGCAAAG
ATGTAGATGAGAGAAATGAGTGTGGCCAGACTCCACTGATGATAGCTGCCGAACAAGGCAATCTGGAAATAGTGAAGGAATTAATTAAGA
ATGGAGCTAACTGCAATCTGGAAGATTTGGATAATTGGACAGCACTTATATCTGCATCGAAAGAAGGGCATGTGCACATCGTAGAGGAAC
TACTGAAATGTGGGGTTAACTTGGAGCACCGTGATATGGGAGGATGGACAGCTCTTATGTGGGCATGTTACAAAGGCCGTACTGACGTAG
TAGAGTTGCTTCTTTCTCATGGTGCCAATCCAAGTGTCACTGGTCTGTACAGTGTTTACCCAATCATTTGGGCAGCAGGGAGAGGCCATG
CAGATATAGTTCATCTTTTACTGCAAAATGGTGCTAAAGTCAACTGCTCTGATAAGTATGGAACCACCCCTTTAGTTTGGGCTGCACGAA
AGGGTCATTTGGAATGTGTGAAACATTTATTGGCCATGGGAGCTGATGTGGATCAAGAAGGAGCTAATTCAATGACTGCACTTATTGTGG
CAGTGAAAGGAGGTTACACACAGTCAGTAAAAGAAATTTTGAAGAGGAATCCAAATGTAAACTTAACAGATAAAGATGGAAATACAGCTT
TGATGATTGCATCAAAGGAGGGACATACGGAGATTGTGCAGGATCTGCTCGACGCTGGAACATATGTGAACATACCTGACAGGAGTGGGG
ATACTGTGTTGATTGGCGCTGTCAGAGGTGGTCATGTTGAAATTGTTCGAGCGCTTCTCCAAAAATATGCTGATATAGACATTAGAGGAC
AGGATAATAAAACTGCTTTGTATTGGGCTGTTGAGAAAGGAAATGCAACAATGGTGAGAGATATCTTACAGTGCAATCCTGACACTGAAA
TATGCACAAAGGATGGTGAAACGCCACTTATAAAGGCTACCAAGATGAGAAACATTGAAGTGGTGGAGCTGCTGCTAGATAAAGGTGCTA
AAGTGTCTGCTGTAGATAAGAAAGGAGATACTCCCTTGCATATTGCTATTCGTGGAAGGAGCCGGAAACTGGCAGAACTGCTTTTAAGAA
ATCCCAAAGATGGGCGATTACTTTATAGGCCCAACAAAGCAGGCGAGACTCCTTATAATATTGACTGTAGCCATCAGAAGAGTATTTTAA
CTCAAATATTTGGAGCCAGACACTTGTCTCCTACTGAAACAGACGGTGACATGCTTGGATATGATTTATATAGCAGTGCCCTGGCAGATA
TTCTCAGTGAGCCTACCATGCAGCCACCCATTTGTGTGGGGTTATATGCACAGTGGGGAAGTGGGAAATCTTTCTTACTCAAGAAACTAG
AAGACGAAATGAAAACCTTCGCCGGACAACAGATTGAGCCTCTCTTTCAGTTCTCATGGCTCATAGTGTTTCTTACCCTGCTACTTTGTG
GAGGGCTTGGTTTATTGTTTGCCTTCACGGTCCACCCAAATCTTGGAATAGCAGTGTCACTGAGCTTCTTGGCTCTCTTATATATATTCT
TTATTGTCATTTACTTTGGTGGACGAAGAGAAGGAGAGAGTTGGAATTGGGCCTGGGTCCTCAGCACTAGATTGGCAAGACATATTGGAT
ATTTGGAACTCCTCCTTAAATTGATGTTTGTGAATCCACCTGAGTTGCCAGAGCAGACTACTAAAGCTTTACCTGTGAGGTTTTTGTTTA
CAGATTACAATAGACTGTCCAGTGTAGGTGGAGAAACTTCTCTGGCTGAAATGATTGCAACCCTCTCGGATGCTTGTGAAAGAGAGTTTG
GCTTTTTGGCAACCAGGCTTTTTCGAGTATTCAAGACTGAAGATACTCAGGGTAAAAAGAAATGGAAAAAAACATGTTGTCTCCCATCTT
TTGTCATCTTCCTTTTTATCATTGGCTGCATTATATCTGGAATTACTCTTCTGGCTATATTTAGAGTTGACCCAAAGCATCTGACTGTAA
ATGCTGTCCTCATATCAATCGCATCTGTAGTGGGATTGGCCTTTGTGTTGAACTGTCGTACATGGTGGCAAGTGCTGGACTCGCTCCTGA
ATTCCCAAAGAAAACGCCTCCATAATGCAGCCTCCAAACTGCACAAATTGAAAAGTGAAGGATTCATGAAAGTTCTTAAATGTGAAGTGG
AATTGATGGCCAGGATGGCAAAAACCATTGACAGCTTCACTCAGAATCAGACAAGGCTGGTGGTCATCATCGATGGATTAGATGCCTGTG
AGCAGGACAAAGTCCTTCAGATGCTGGACACTGTCCGAGTTCTGTTTTCAAAAGGCCCGTTCATTGCCATTTTTGCAAGTGATCCACATA
TTATCATAAAGGCAATTAACCAGAACCTCAATAGTGTGCTTCGGGATTCAAATATAAATGGCCATGACTACATGCGCAACATAGTCCACT
TGCCTGTGTTCCTTAATAGTCGTGGACTAAGCAATGCAAGAAAATTTCTCGTAACTTCAGCAACAAATGGAGACGTTCCATGCTCAGATA
CTACAGGGATACAGGAAGATGCTGACAGAAGAGTTTCACAGAACAGCCTTGGGGAGATGACAAAACTTGGTAGCAAGACAGCCCTCAATA
GACGGGACACTTACCGAAGAAGGCAGATGCAGAGGACCATCACTCGCCAGATGTCCTTTGATCTTACAAAACTGCTGGTTACCGAGGACT
GGTTCAGTGACATCAGTCCCCAGACCATGAGAAGATTACTTAATATTGTTTCTGTGACAGGACGATTACTGAGAGCCAATCAGATTAGTT
TCAACTGGGACAGGCTTGCTAGCTGGATCAACCTTACTGAGCAGTGGCCATACCGGACTTCATGGCTCATATTATATTTGGAAGAGACTG
AAGGTATTCCAGATCAAATGACATTAAAAACCATCTACGAAAGAATATCAAAGAATATTCCAACAACTAAGGATGTTGAGCCACTTCTTG
AAATTGATGGAGATATAAGAAATTTTGAAGTGTTTTTGTCTTCAAGGACCCCAGTTCTTGTGGCTCGAGATGTAAAAGTCTTTTTGCCAT
GCACTGTAAACCTAGATCCCAAACTACGGGAAATTATTGCAGATGTTCGTGCTGCCAGAGAGCAGATCAGTATTGGAGGACTGGCGTACC
CCCCGCTCCCTCTACATGAGGGTCCTCCTAGGGCGCCATCAGGGTACAGCCAGCCCCCATCCGTGTGCTCTTCCACGTCCTTCAATGGGC
CCTTCGCAGGTGGAGTGGTGTCACCACAGCCTCACAGCAGCTATTACAGCGGCATGACGGGCCCTCAGCATCCCTTCTACAACAGGGTCG
GCGGAAGCAGAAGTGGGCTGTGGATCCTCAGAACACTGCCTGGAGTAATGACGATTCCAAGTTTGGCCAGCGGATGCTAGAGAAGATGGG
GTGGTCTAAAGGAAAGGGTTTAGGGGCTCAGGAGCAAGGAGCCACAGATCATATTAAAGTTCAAGTGAAAAATAACCACCTGGGACTCGG
AGCTACCATCAATAATGAAGACAACTGGATTGCCCATCAGGATGATTTTAACCAGCTTCTGGCCGAACTGAACACTTGCCATGGGCAGGA
AACCACAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAA
ATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAAGAAGACTCCCGAGGG
CGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGC
ACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGA
GGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCG
AGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGG
GGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGAT
AGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGAC
CACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGG
CATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGG
CTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTA
AGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTTCCCTTCAATAACAAT

>In-frame_ENST00000418530_ENST00000314787_TCGA-X6-A8C6-01A_KIDINS220_chr2_8890242_-_PINX1_chr8_10692285_length(amino acids)=1171AA_start in transcript=164_stop in transcript=3679
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLIL
YLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISI
GGLAYPPLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRVGGSRSGLWILRTLPGVMTIPSLASG

--------------------------------------------------------------
>In-frame_ENST00000418530_ENST00000426190_TCGA-X6-A8C6-01A_KIDINS220_chr2_8890242_-_PINX1_chr8_10692285_length(transcript)=4923nt_BP=3596nt
ACGTGATCTGTCAGTTCGCGGAGAGGGAAGAATATGGCCGCCGGGTGTGGTGAGGGCGACGCGCTTGCAGTCGCCGTCTCTTGCTTCCCC
GTCCTCTGACATCGCCTGCAGCCGAGCGGGCCCGTTCCGCCGGAGCTGAGGACCAGGTATTCAAATAAAGTTAATTGCAGCTTTCTGTGA
AAATGTCAGTTTTGATATCACAGAGCGTCATAAATTATGTAGAGGAAGAAAACATTCCTGCTCTGAAAGCTCTTCTTGAAAAATGCAAAG
ATGTAGATGAGAGAAATGAGTGTGGCCAGACTCCACTGATGATAGCTGCCGAACAAGGCAATCTGGAAATAGTGAAGGAATTAATTAAGA
ATGGAGCTAACTGCAATCTGGAAGATTTGGATAATTGGACAGCACTTATATCTGCATCGAAAGAAGGGCATGTGCACATCGTAGAGGAAC
TACTGAAATGTGGGGTTAACTTGGAGCACCGTGATATGGGAGGATGGACAGCTCTTATGTGGGCATGTTACAAAGGCCGTACTGACGTAG
TAGAGTTGCTTCTTTCTCATGGTGCCAATCCAAGTGTCACTGGTCTGTACAGTGTTTACCCAATCATTTGGGCAGCAGGGAGAGGCCATG
CAGATATAGTTCATCTTTTACTGCAAAATGGTGCTAAAGTCAACTGCTCTGATAAGTATGGAACCACCCCTTTAGTTTGGGCTGCACGAA
AGGGTCATTTGGAATGTGTGAAACATTTATTGGCCATGGGAGCTGATGTGGATCAAGAAGGAGCTAATTCAATGACTGCACTTATTGTGG
CAGTGAAAGGAGGTTACACACAGTCAGTAAAAGAAATTTTGAAGAGGAATCCAAATGTAAACTTAACAGATAAAGATGGAAATACAGCTT
TGATGATTGCATCAAAGGAGGGACATACGGAGATTGTGCAGGATCTGCTCGACGCTGGAACATATGTGAACATACCTGACAGGAGTGGGG
ATACTGTGTTGATTGGCGCTGTCAGAGGTGGTCATGTTGAAATTGTTCGAGCGCTTCTCCAAAAATATGCTGATATAGACATTAGAGGAC
AGGATAATAAAACTGCTTTGTATTGGGCTGTTGAGAAAGGAAATGCAACAATGGTGAGAGATATCTTACAGTGCAATCCTGACACTGAAA
TATGCACAAAGGATGGTGAAACGCCACTTATAAAGGCTACCAAGATGAGAAACATTGAAGTGGTGGAGCTGCTGCTAGATAAAGGTGCTA
AAGTGTCTGCTGTAGATAAGAAAGGAGATACTCCCTTGCATATTGCTATTCGTGGAAGGAGCCGGAAACTGGCAGAACTGCTTTTAAGAA
ATCCCAAAGATGGGCGATTACTTTATAGGCCCAACAAAGCAGGCGAGACTCCTTATAATATTGACTGTAGCCATCAGAAGAGTATTTTAA
CTCAAATATTTGGAGCCAGACACTTGTCTCCTACTGAAACAGACGGTGACATGCTTGGATATGATTTATATAGCAGTGCCCTGGCAGATA
TTCTCAGTGAGCCTACCATGCAGCCACCCATTTGTGTGGGGTTATATGCACAGTGGGGAAGTGGGAAATCTTTCTTACTCAAGAAACTAG
AAGACGAAATGAAAACCTTCGCCGGACAACAGATTGAGCCTCTCTTTCAGTTCTCATGGCTCATAGTGTTTCTTACCCTGCTACTTTGTG
GAGGGCTTGGTTTATTGTTTGCCTTCACGGTCCACCCAAATCTTGGAATAGCAGTGTCACTGAGCTTCTTGGCTCTCTTATATATATTCT
TTATTGTCATTTACTTTGGTGGACGAAGAGAAGGAGAGAGTTGGAATTGGGCCTGGGTCCTCAGCACTAGATTGGCAAGACATATTGGAT
ATTTGGAACTCCTCCTTAAATTGATGTTTGTGAATCCACCTGAGTTGCCAGAGCAGACTACTAAAGCTTTACCTGTGAGGTTTTTGTTTA
CAGATTACAATAGACTGTCCAGTGTAGGTGGAGAAACTTCTCTGGCTGAAATGATTGCAACCCTCTCGGATGCTTGTGAAAGAGAGTTTG
GCTTTTTGGCAACCAGGCTTTTTCGAGTATTCAAGACTGAAGATACTCAGGGTAAAAAGAAATGGAAAAAAACATGTTGTCTCCCATCTT
TTGTCATCTTCCTTTTTATCATTGGCTGCATTATATCTGGAATTACTCTTCTGGCTATATTTAGAGTTGACCCAAAGCATCTGACTGTAA
ATGCTGTCCTCATATCAATCGCATCTGTAGTGGGATTGGCCTTTGTGTTGAACTGTCGTACATGGTGGCAAGTGCTGGACTCGCTCCTGA
ATTCCCAAAGAAAACGCCTCCATAATGCAGCCTCCAAACTGCACAAATTGAAAAGTGAAGGATTCATGAAAGTTCTTAAATGTGAAGTGG
AATTGATGGCCAGGATGGCAAAAACCATTGACAGCTTCACTCAGAATCAGACAAGGCTGGTGGTCATCATCGATGGATTAGATGCCTGTG
AGCAGGACAAAGTCCTTCAGATGCTGGACACTGTCCGAGTTCTGTTTTCAAAAGGCCCGTTCATTGCCATTTTTGCAAGTGATCCACATA
TTATCATAAAGGCAATTAACCAGAACCTCAATAGTGTGCTTCGGGATTCAAATATAAATGGCCATGACTACATGCGCAACATAGTCCACT
TGCCTGTGTTCCTTAATAGTCGTGGACTAAGCAATGCAAGAAAATTTCTCGTAACTTCAGCAACAAATGGAGACGTTCCATGCTCAGATA
CTACAGGGATACAGGAAGATGCTGACAGAAGAGTTTCACAGAACAGCCTTGGGGAGATGACAAAACTTGGTAGCAAGACAGCCCTCAATA
GACGGGACACTTACCGAAGAAGGCAGATGCAGAGGACCATCACTCGCCAGATGTCCTTTGATCTTACAAAACTGCTGGTTACCGAGGACT
GGTTCAGTGACATCAGTCCCCAGACCATGAGAAGATTACTTAATATTGTTTCTGTGACAGGACGATTACTGAGAGCCAATCAGATTAGTT
TCAACTGGGACAGGCTTGCTAGCTGGATCAACCTTACTGAGCAGTGGCCATACCGGACTTCATGGCTCATATTATATTTGGAAGAGACTG
AAGGTATTCCAGATCAAATGACATTAAAAACCATCTACGAAAGAATATCAAAGAATATTCCAACAACTAAGGATGTTGAGCCACTTCTTG
AAATTGATGGAGATATAAGAAATTTTGAAGTGTTTTTGTCTTCAAGGACCCCAGTTCTTGTGGCTCGAGATGTAAAAGTCTTTTTGCCAT
GCACTGTAAACCTAGATCCCAAACTACGGGAAATTATTGCAGATGTTCGTGCTGCCAGAGAGCAGATCAGTATTGGAGGACTGGCGTACC
CCCCGCTCCCTCTACATGAGGGTCCTCCTAGGGCGCCATCAGGGTACAGCCAGCCCCCATCCGTGTGCTCTTCCACGTCCTTCAATGGGC
CCTTCGCAGGTGGAGTGGTGTCACCACAGCCTCACAGCAGCTATTACAGCGGCATGACGGGCCCTCAGCATCCCTTCTACAACAGGGTCG
GCGGAAGCAGAAGTGGGCTGTGGATCCTCAGAACACTGCCTGGAGTAATGACGATTCCAAGTTTGGCCAGCGGATGCTAGAGAAGATGGG
GTGGTCTAAAGGAAAGGGTTTAGGGGCTCAGGAGCAAGGAGCCACAGATCATATTAAAGTTCAAGTGAAAAATAACCACCTGGGACTCGG
AGCTACCATCAATAATGAAGACAACTGGATTGCCCATCAGGATGATTTTAACCAGCTTCTGGCCGAACTGAACACTTGCCATGGGCAGGA
AACCACAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAA
ATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCA
AGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGA
AAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCG
AGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTG
CTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAA
AACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAGCC
GGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGG
GCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATG
TTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAATAC
ATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTTCC

>In-frame_ENST00000418530_ENST00000426190_TCGA-X6-A8C6-01A_KIDINS220_chr2_8890242_-_PINX1_chr8_10692285_length(amino acids)=1171AA_start in transcript=164_stop in transcript=3679
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLIL
YLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISI
GGLAYPPLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRVGGSRSGLWILRTLPGVMTIPSLASG

--------------------------------------------------------------
>In-frame_ENST00000418530_ENST00000519088_TCGA-X6-A8C6-01A_KIDINS220_chr2_8890242_-_PINX1_chr8_10692285_length(transcript)=4729nt_BP=3596nt
ACGTGATCTGTCAGTTCGCGGAGAGGGAAGAATATGGCCGCCGGGTGTGGTGAGGGCGACGCGCTTGCAGTCGCCGTCTCTTGCTTCCCC
GTCCTCTGACATCGCCTGCAGCCGAGCGGGCCCGTTCCGCCGGAGCTGAGGACCAGGTATTCAAATAAAGTTAATTGCAGCTTTCTGTGA
AAATGTCAGTTTTGATATCACAGAGCGTCATAAATTATGTAGAGGAAGAAAACATTCCTGCTCTGAAAGCTCTTCTTGAAAAATGCAAAG
ATGTAGATGAGAGAAATGAGTGTGGCCAGACTCCACTGATGATAGCTGCCGAACAAGGCAATCTGGAAATAGTGAAGGAATTAATTAAGA
ATGGAGCTAACTGCAATCTGGAAGATTTGGATAATTGGACAGCACTTATATCTGCATCGAAAGAAGGGCATGTGCACATCGTAGAGGAAC
TACTGAAATGTGGGGTTAACTTGGAGCACCGTGATATGGGAGGATGGACAGCTCTTATGTGGGCATGTTACAAAGGCCGTACTGACGTAG
TAGAGTTGCTTCTTTCTCATGGTGCCAATCCAAGTGTCACTGGTCTGTACAGTGTTTACCCAATCATTTGGGCAGCAGGGAGAGGCCATG
CAGATATAGTTCATCTTTTACTGCAAAATGGTGCTAAAGTCAACTGCTCTGATAAGTATGGAACCACCCCTTTAGTTTGGGCTGCACGAA
AGGGTCATTTGGAATGTGTGAAACATTTATTGGCCATGGGAGCTGATGTGGATCAAGAAGGAGCTAATTCAATGACTGCACTTATTGTGG
CAGTGAAAGGAGGTTACACACAGTCAGTAAAAGAAATTTTGAAGAGGAATCCAAATGTAAACTTAACAGATAAAGATGGAAATACAGCTT
TGATGATTGCATCAAAGGAGGGACATACGGAGATTGTGCAGGATCTGCTCGACGCTGGAACATATGTGAACATACCTGACAGGAGTGGGG
ATACTGTGTTGATTGGCGCTGTCAGAGGTGGTCATGTTGAAATTGTTCGAGCGCTTCTCCAAAAATATGCTGATATAGACATTAGAGGAC
AGGATAATAAAACTGCTTTGTATTGGGCTGTTGAGAAAGGAAATGCAACAATGGTGAGAGATATCTTACAGTGCAATCCTGACACTGAAA
TATGCACAAAGGATGGTGAAACGCCACTTATAAAGGCTACCAAGATGAGAAACATTGAAGTGGTGGAGCTGCTGCTAGATAAAGGTGCTA
AAGTGTCTGCTGTAGATAAGAAAGGAGATACTCCCTTGCATATTGCTATTCGTGGAAGGAGCCGGAAACTGGCAGAACTGCTTTTAAGAA
ATCCCAAAGATGGGCGATTACTTTATAGGCCCAACAAAGCAGGCGAGACTCCTTATAATATTGACTGTAGCCATCAGAAGAGTATTTTAA
CTCAAATATTTGGAGCCAGACACTTGTCTCCTACTGAAACAGACGGTGACATGCTTGGATATGATTTATATAGCAGTGCCCTGGCAGATA
TTCTCAGTGAGCCTACCATGCAGCCACCCATTTGTGTGGGGTTATATGCACAGTGGGGAAGTGGGAAATCTTTCTTACTCAAGAAACTAG
AAGACGAAATGAAAACCTTCGCCGGACAACAGATTGAGCCTCTCTTTCAGTTCTCATGGCTCATAGTGTTTCTTACCCTGCTACTTTGTG
GAGGGCTTGGTTTATTGTTTGCCTTCACGGTCCACCCAAATCTTGGAATAGCAGTGTCACTGAGCTTCTTGGCTCTCTTATATATATTCT
TTATTGTCATTTACTTTGGTGGACGAAGAGAAGGAGAGAGTTGGAATTGGGCCTGGGTCCTCAGCACTAGATTGGCAAGACATATTGGAT
ATTTGGAACTCCTCCTTAAATTGATGTTTGTGAATCCACCTGAGTTGCCAGAGCAGACTACTAAAGCTTTACCTGTGAGGTTTTTGTTTA
CAGATTACAATAGACTGTCCAGTGTAGGTGGAGAAACTTCTCTGGCTGAAATGATTGCAACCCTCTCGGATGCTTGTGAAAGAGAGTTTG
GCTTTTTGGCAACCAGGCTTTTTCGAGTATTCAAGACTGAAGATACTCAGGGTAAAAAGAAATGGAAAAAAACATGTTGTCTCCCATCTT
TTGTCATCTTCCTTTTTATCATTGGCTGCATTATATCTGGAATTACTCTTCTGGCTATATTTAGAGTTGACCCAAAGCATCTGACTGTAA
ATGCTGTCCTCATATCAATCGCATCTGTAGTGGGATTGGCCTTTGTGTTGAACTGTCGTACATGGTGGCAAGTGCTGGACTCGCTCCTGA
ATTCCCAAAGAAAACGCCTCCATAATGCAGCCTCCAAACTGCACAAATTGAAAAGTGAAGGATTCATGAAAGTTCTTAAATGTGAAGTGG
AATTGATGGCCAGGATGGCAAAAACCATTGACAGCTTCACTCAGAATCAGACAAGGCTGGTGGTCATCATCGATGGATTAGATGCCTGTG
AGCAGGACAAAGTCCTTCAGATGCTGGACACTGTCCGAGTTCTGTTTTCAAAAGGCCCGTTCATTGCCATTTTTGCAAGTGATCCACATA
TTATCATAAAGGCAATTAACCAGAACCTCAATAGTGTGCTTCGGGATTCAAATATAAATGGCCATGACTACATGCGCAACATAGTCCACT
TGCCTGTGTTCCTTAATAGTCGTGGACTAAGCAATGCAAGAAAATTTCTCGTAACTTCAGCAACAAATGGAGACGTTCCATGCTCAGATA
CTACAGGGATACAGGAAGATGCTGACAGAAGAGTTTCACAGAACAGCCTTGGGGAGATGACAAAACTTGGTAGCAAGACAGCCCTCAATA
GACGGGACACTTACCGAAGAAGGCAGATGCAGAGGACCATCACTCGCCAGATGTCCTTTGATCTTACAAAACTGCTGGTTACCGAGGACT
GGTTCAGTGACATCAGTCCCCAGACCATGAGAAGATTACTTAATATTGTTTCTGTGACAGGACGATTACTGAGAGCCAATCAGATTAGTT
TCAACTGGGACAGGCTTGCTAGCTGGATCAACCTTACTGAGCAGTGGCCATACCGGACTTCATGGCTCATATTATATTTGGAAGAGACTG
AAGGTATTCCAGATCAAATGACATTAAAAACCATCTACGAAAGAATATCAAAGAATATTCCAACAACTAAGGATGTTGAGCCACTTCTTG
AAATTGATGGAGATATAAGAAATTTTGAAGTGTTTTTGTCTTCAAGGACCCCAGTTCTTGTGGCTCGAGATGTAAAAGTCTTTTTGCCAT
GCACTGTAAACCTAGATCCCAAACTACGGGAAATTATTGCAGATGTTCGTGCTGCCAGAGAGCAGATCAGTATTGGAGGACTGGCGTACC
CCCCGCTCCCTCTACATGAGGGTCCTCCTAGGGCGCCATCAGGGTACAGCCAGCCCCCATCCGTGTGCTCTTCCACGTCCTTCAATGGGC
CCTTCGCAGGTGGAGTGGTGTCACCACAGCCTCACAGCAGCTATTACAGCGGCATGACGGGCCCTCAGCATCCCTTCTACAACAGGGTCG
GCGGAAGCAGAAGTGGGCTGTGGATCCTCAGAACACTGCCTGGAGTAATGACGATTCCAAGTTTGGCCAGCGGATGCTAGAGAAGATGGG
GTGGTCTAAAGGAAAGGGTTTAGGGGCTCAGGAGCAAGGAGCCACAGATCATATTAAAGTTCAAGTGAAAAATAACCACCTGGGACTCGG
AGCTACCATCAATAATGAAGACAACTGGATTGCCCATCAGGATGATTTTAACCAGCTTCTGGCCGAACTGAACACTTGCCATGGGCAGGA
AACCACAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAA
ATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCA
AGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGA
AAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCG
AGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTG
CTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAA
AACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAGCC
GGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCTGG
GCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAATG

>In-frame_ENST00000418530_ENST00000519088_TCGA-X6-A8C6-01A_KIDINS220_chr2_8890242_-_PINX1_chr8_10692285_length(amino acids)=1171AA_start in transcript=164_stop in transcript=3679
MQLSVKMSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHV
HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL
VWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI
PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL
LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYS
SALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLA
LLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQV
LDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIF
ASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGS
KTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLIL
YLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISI
GGLAYPPLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRVGGSRSGLWILRTLPGVMTIPSLASG

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Fusion Gene PPI Analysis for KIDINS220-PINX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIDINS220-PINX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIDINS220-PINX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIDINS220C4284592SPASTIC PARAPLEGIA, INTELLECTUAL DISABILITY, NYSTAGMUS, AND OBESITY2GENOMICS_ENGLAND;ORPHANET