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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF23-PAQR5 (FusionGDB2 ID:42457)

Fusion Gene Summary for KIF23-PAQR5

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF23-PAQR5
Fusion gene ID: 42457
HgeneTgene
Gene symbol

KIF23

PAQR5

Gene ID

9493

54852

Gene namekinesin family member 23progestin and adipoQ receptor family member 5
SynonymsCHO1|KNSL5|MKLP-1|MKLP1MPRG
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF23kinesin-like 5 (mitotic kinesin-like protein 1)membrane progestin receptor gammamPR gammamembrane progesterone P4 receptor gammamembrane progesterone receptor gammaprogesterone and adipoQ receptor family member 5progestin and adipoQ receptor family member V
Modification date2020031320200313
UniProtAcc

Q02241

.
Ensembl transtripts involved in fusion geneENST00000559279, ENST00000395392, 
ENST00000352331, ENST00000260363, 
ENST00000558585, ENST00000537891, 
ENST00000395407, ENST00000561153, 
ENST00000340965, ENST00000561027, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 7 X 4=168
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF23 [Title/Abstract] AND PAQR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF23(69709850)-PAQR5(69695920), # samples:2
Anticipated loss of major functional domain due to fusion event.KIF23-PAQR5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIF23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PAQR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NEKIF23chr15

69709850

+PAQR5chr15

69695920

+
ChimerDB4ESCATCGA-L5-A8NE-01AKIF23chr15

69709850

-PAQR5chr15

69695920

+


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Fusion Gene ORF analysis for KIF23-PAQR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000559279ENST00000395407KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000559279ENST00000561153KIF23chr15

69709850

+PAQR5chr15

69695920

+
In-frameENST00000559279ENST00000340965KIF23chr15

69709850

+PAQR5chr15

69695920

+
5CDS-intronENST00000559279ENST00000561027KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000395392ENST00000395407KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000395392ENST00000561153KIF23chr15

69709850

+PAQR5chr15

69695920

+
In-frameENST00000395392ENST00000340965KIF23chr15

69709850

+PAQR5chr15

69695920

+
5CDS-intronENST00000395392ENST00000561027KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000352331ENST00000395407KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000352331ENST00000561153KIF23chr15

69709850

+PAQR5chr15

69695920

+
In-frameENST00000352331ENST00000340965KIF23chr15

69709850

+PAQR5chr15

69695920

+
5CDS-intronENST00000352331ENST00000561027KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000260363ENST00000395407KIF23chr15

69709850

+PAQR5chr15

69695920

+
Frame-shiftENST00000260363ENST00000561153KIF23chr15

69709850

+PAQR5chr15

69695920

+
In-frameENST00000260363ENST00000340965KIF23chr15

69709850

+PAQR5chr15

69695920

+
5CDS-intronENST00000260363ENST00000561027KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-3CDSENST00000558585ENST00000395407KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-3CDSENST00000558585ENST00000561153KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-3CDSENST00000558585ENST00000340965KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-intronENST00000558585ENST00000561027KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-3CDSENST00000537891ENST00000395407KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-3CDSENST00000537891ENST00000561153KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-3CDSENST00000537891ENST00000340965KIF23chr15

69709850

+PAQR5chr15

69695920

+
intron-intronENST00000537891ENST00000561027KIF23chr15

69709850

+PAQR5chr15

69695920

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KIF23-PAQR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIF23chr1569709850+PAQR5chr1569695919+2.02E-050.99997985
KIF23chr1569709850+PAQR5chr1569695919+2.02E-050.99997985

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIF23-PAQR5


check button Go to

FGviewer for the breakpoints of chr15:69709850-chr15:69695920

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF23

Q02241

.
FUNCTION: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF23chr15:69709850chr15:69695920ENST00000260363+3237_1170.0961.0MotifNuclear localization signal
HgeneKIF23chr15:69709850chr15:69695920ENST00000352331+3227_1170.0857.0MotifNuclear localization signal
HgeneKIF23chr15:69709850chr15:69695920ENST00000559279+3227_1170.0857.0MotifNuclear localization signal
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579275_294250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579316_330250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779275_294250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779316_330250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379275_294250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379316_330250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579254_274250.33333333333334331.0TransmembraneHelical%3B Name%3D6
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579295_315250.33333333333334331.0TransmembraneHelical%3B Name%3D7
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779254_274250.33333333333334331.0TransmembraneHelical%3B Name%3D6
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779295_315250.33333333333334331.0TransmembraneHelical%3B Name%3D7
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379254_274250.33333333333334331.0TransmembraneHelical%3B Name%3D6
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379295_315250.33333333333334331.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF23chr15:69709850chr15:69695920ENST00000260363+323535_62070.0961.0Coiled coilOntology_term=ECO:0000255
HgeneKIF23chr15:69709850chr15:69695920ENST00000352331+322535_62070.0857.0Coiled coilOntology_term=ECO:0000255
HgeneKIF23chr15:69709850chr15:69695920ENST00000559279+322535_62070.0857.0Coiled coilOntology_term=ECO:0000255
HgeneKIF23chr15:69709850chr15:69695920ENST00000260363+32325_43670.0961.0DomainKinesin motor
HgeneKIF23chr15:69709850chr15:69695920ENST00000352331+32225_43670.0857.0DomainKinesin motor
HgeneKIF23chr15:69709850chr15:69695920ENST00000559279+32225_43670.0857.0DomainKinesin motor
HgeneKIF23chr15:69709850chr15:69695920ENST00000260363+323112_11970.0961.0Nucleotide bindingATP
HgeneKIF23chr15:69709850chr15:69695920ENST00000352331+322112_11970.0857.0Nucleotide bindingATP
HgeneKIF23chr15:69709850chr15:69695920ENST00000559279+322112_11970.0857.0Nucleotide bindingATP
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579102_113250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579135_141250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579163_186250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST00000340965791_51250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579208_253250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST000003409657973_80250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779102_113250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779135_141250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779163_186250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST00000395407791_51250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779208_253250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST000003954077973_80250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379102_113250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379135_141250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379163_186250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST00000561153791_51250.33333333333334331.0Topological domainCytoplasmic
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379208_253250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST000005611537973_80250.33333333333334331.0Topological domainExtracellular
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579114_134250.33333333333334331.0TransmembraneHelical%3B Name%3D3
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579142_162250.33333333333334331.0TransmembraneHelical%3B Name%3D4
TgenePAQR5chr15:69709850chr15:69695920ENST0000034096579187_207250.33333333333334331.0TransmembraneHelical%3B Name%3D5
TgenePAQR5chr15:69709850chr15:69695920ENST000003409657952_72250.33333333333334331.0TransmembraneHelical%3B Name%3D1
TgenePAQR5chr15:69709850chr15:69695920ENST000003409657981_101250.33333333333334331.0TransmembraneHelical%3B Name%3D2
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779114_134250.33333333333334331.0TransmembraneHelical%3B Name%3D3
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779142_162250.33333333333334331.0TransmembraneHelical%3B Name%3D4
TgenePAQR5chr15:69709850chr15:69695920ENST0000039540779187_207250.33333333333334331.0TransmembraneHelical%3B Name%3D5
TgenePAQR5chr15:69709850chr15:69695920ENST000003954077952_72250.33333333333334331.0TransmembraneHelical%3B Name%3D1
TgenePAQR5chr15:69709850chr15:69695920ENST000003954077981_101250.33333333333334331.0TransmembraneHelical%3B Name%3D2
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379114_134250.33333333333334331.0TransmembraneHelical%3B Name%3D3
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379142_162250.33333333333334331.0TransmembraneHelical%3B Name%3D4
TgenePAQR5chr15:69709850chr15:69695920ENST0000056115379187_207250.33333333333334331.0TransmembraneHelical%3B Name%3D5
TgenePAQR5chr15:69709850chr15:69695920ENST000005611537952_72250.33333333333334331.0TransmembraneHelical%3B Name%3D1
TgenePAQR5chr15:69709850chr15:69695920ENST000005611537981_101250.33333333333334331.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for KIF23-PAQR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KIF23-PAQR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKIF23chr15:69709850chr15:69695920ENST00000260363+323794_91170.0961.0ARF6
HgeneKIF23chr15:69709850chr15:69695920ENST00000352331+322794_91170.0857.0ARF6
HgeneKIF23chr15:69709850chr15:69695920ENST00000559279+322794_91170.0857.0ARF6


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF23-PAQR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF23-PAQR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF23C0271934Congenital dyserythropoietic anemia, type III2GENOMICS_ENGLAND;ORPHANET
HgeneKIF23C0520572Enzymopathy2GENOMICS_ENGLAND
HgeneKIF23C2239176Liver carcinoma1CTD_human