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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KIF26B-UBE2Q1 (FusionGDB2 ID:42481) |
Fusion Gene Summary for KIF26B-UBE2Q1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KIF26B-UBE2Q1 | Fusion gene ID: 42481 | Hgene | Tgene | Gene symbol | KIF26B | UBE2Q1 | Gene ID | 55083 | 55585 |
| Gene name | kinesin family member 26B | ubiquitin conjugating enzyme E2 Q1 | |
| Synonyms | - | GTAP|NICE-5|NICE5|PRO3094|UBE2Q | |
| Cytomap | 1q44 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kinesin-like protein KIF26B | ubiquitin-conjugating enzyme E2 Q1E2 ubiquitin-conjugating enzyme Q1galactosyl transferase-associated proteinprotein NICE-5ubiquitin carrier protein Q1ubiquitin conjugating enzyme E2Q family member 1ubiquitin-conjugating enzyme E2Q (putative) 1ubiq | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000407071, ENST00000366518, ENST00000479506, | ENST00000292211, ENST00000497453, | |
| Fusion gene scores | * DoF score | 9 X 11 X 10=990 | 5 X 4 X 4=80 |
| # samples | 18 | 5 | |
| ** MAII score | log2(18/990*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KIF26B [Title/Abstract] AND UBE2Q1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KIF26B(245583047)-UBE2Q1(154524295), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across KIF26B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across UBE2Q1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-AJ-A3EM-01A | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| ChimerDB4 | UCEC | TCGA-AJ-A3EM-01A | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
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Fusion Gene ORF analysis for KIF26B-UBE2Q1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000407071 | ENST00000292211 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| 5CDS-intron | ENST00000407071 | ENST00000497453 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| intron-3CDS | ENST00000366518 | ENST00000292211 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| intron-intron | ENST00000366518 | ENST00000497453 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| intron-3CDS | ENST00000479506 | ENST00000292211 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| intron-intron | ENST00000479506 | ENST00000497453 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000407071 | KIF26B | chr1 | 245583047 | + | ENST00000292211 | UBE2Q1 | chr1 | 154524295 | - | 3711 | 1606 | 440 | 1849 | 469 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000407071 | ENST00000292211 | KIF26B | chr1 | 245583047 | + | UBE2Q1 | chr1 | 154524295 | - | 0.012286237 | 0.9877138 |
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Fusion Genomic Features for KIF26B-UBE2Q1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KIF26B-UBE2Q1 |
| Go to FGviewer for the breakpoints of chr1:245583047-chr1:154524295 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KIF26B | chr1:245583047 | chr1:154524295 | ENST00000407071 | + | 4 | 15 | 58_126 | 388.6666666666667 | 2109.0 | Compositional bias | Note=Gly-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KIF26B | chr1:245583047 | chr1:154524295 | ENST00000407071 | + | 4 | 15 | 1649_1797 | 388.6666666666667 | 2109.0 | Compositional bias | Note=Ser-rich |
| Hgene | KIF26B | chr1:245583047 | chr1:154524295 | ENST00000407071 | + | 4 | 15 | 450_801 | 388.6666666666667 | 2109.0 | Domain | Kinesin motor |
| Hgene | KIF26B | chr1:245583047 | chr1:154524295 | ENST00000407071 | + | 4 | 15 | 546_553 | 388.6666666666667 | 2109.0 | Nucleotide binding | ATP |
| Tgene | UBE2Q1 | chr1:245583047 | chr1:154524295 | ENST00000292211 | 8 | 13 | 8_38 | 341.6666666666667 | 423.0 | Compositional bias | Note=Gly-rich | |
| Tgene | UBE2Q1 | chr1:245583047 | chr1:154524295 | ENST00000292211 | 8 | 13 | 251_415 | 341.6666666666667 | 423.0 | Domain | UBC core |
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Fusion Gene Sequence for KIF26B-UBE2Q1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000407071_ENST00000292211_TCGA-AJ-A3EM-01A_KIF26B_chr1_245583047_+_UBE2Q1_chr1_154524295_length(transcript)=3711nt_BP=1606nt AGTTACCAAGCTCGGTGAAGGAGACAAGTTCCCACAGCTGACTCGGCTCGGCTCTCCCACCTTCCCGGCAGCGGCCGCGAGCCCTGATTG TATCCCTCGCTTTCCTCGTGGGGGAGCACGGACTGACTTGGCTGAAGAAAATGCCAGTTCTGTGGATGTGGCCGTGACAAGAGGACGTGC GGCTGGAAGAGGCAGAAGGGGACGAGGAAAAGCATGCTTTGAAGAGAAGAATAAACCAGCGACCCCAACCCTTTCTGCAAATTGGTGCTA TTACTTGTGGGATCCATTTGCTTTCATTCCCTCCCACCCCACCGCTGAAGAAACCTTGCCCTGAGGGCTGAGAGCCAGCCCCCTGCAGCC GGGGGACGCTTCTGGGTTGGAGGACCTTCTGGATGTAGCGTCGGTGGAACCTTTAGATACTCTCCTCTGGAAAAGCCACCATGAATTCGG TAGCTGGGAATAAAGAGAGGCTTGCGGTCTCCACCAGGGGCAAGAAATACGGGGTGAATGAAGTCTGCTCGCCCACCAAGCCCGCAGCGC CCTTCTCCCCGGAAAGCTGGTACCGGAAAGCATACGAGGAGTCGCGCGCCGGCAGCCGGCCCACTCCTGAGGGCGCGGGCTCAGCGCTCG GCTCCTCGGGGACCCCGTCTCCCGGCTCGGGCACCTCGTCCCCGAGCTCGTTCACCGGCTCCCCGGGACCCGCCTCCCCCGGCATCGGCA CTAGTTCGCCGGGCTCCTTGGGCGGCTCTCCGGGCTTCGGCACAGGCTCCCCGGGCTCCGGCAGCGGCGGCGGCTCCTCCCCCGGCTCGG ACCGCGGCGTCTGGTGCGAGAACTGCAACGCCCGCCTGGTGGAGCTCAAGAGGCAGGCCCTGAGGTTGCTCCTCCCGGGGCCCTTCCCGG GCAAGGACCCTGCTTTCTCGGCTGTGATTCACGACAAACTCCAGGTCCCCAACACCATCCGGAAGGCATGGAACGACCGGGACAACCGCT GTGACATTTGCGCCACTCACCTGAACCAGTTGAAGCAGGAGGCCATCCAGATGGTGCTGACGTTGGAGCAGGCAGCCGGCAGTGAGCACT ACGACGCCTCGCCCTGCTCCCCGCCACCGCTCTCCAACATCCCCACCCTGGTGGGGTCCCGGCACGTGGGTGGGCTCCAGCAGCCCAGAG ACTGGGCCTTTGTGCCCGCCCCCTGTGCCACCTCCAACTACACAGGCTTCGCCAACAAGCACGGCAGCAAACCCAGCAGCCTTGGGGTCA GCAATGGGGCGGAAAAGAAGAGCGGGTCCCCAACCCACCAGGCCAAGGTCAGCCTCCAGATGGCCACCAGTCCAAGCAATGGGAACATCC TCAATTCGGTGGCCATCCAGGCTCACCAGTACCTGGATGGCACCTGGTCCCTGTCGAGAACCAACGGGGTCACCCTGTACCCATACCAGA TCTCCCAGCTGATGACAGAGAGTAGCCGGGAGGGACTAACAGAAGCAGTGCTGAACCGCTACAATGCAGACAAGCCTTCCGCCTGCAGTG TCCCAGCCTCGCAGGGCTCCTGCGTGGCCAGCGAGACTTCCACAGGCACATCGGTGGCCGCCTCCTTCTTTGCACGGTATGTTCTGGGCG GAGGGGCCATCTGCATGGAACTTCTCACCAAACAGGGCTGGAGCAGTGCCTACTCCATAGAGTCAGTGATCATGCAGATCAGTGCCACAC TGGTGAAGGGGAAAGCACGAGTGCAGTTTGGAGCCAACAAATCTCAATACAGTCTGACAAGAGCACAGCAGTCCTACAAGTCCTTGGTGC AGATCCACGAAAAAAACGGCTGGTACACACCCCCAAAAGAAGACGGCTAACCCTGGAGTATCACCCTTCCTCCCTCCCCAGGCACCACTG GACCAATTACCTTTGAATGCTGTATTTGGATCTCACGCTGCCTCTGTGGTTCCCTCCCTCATTTTTCCTGGACGTGATAGCTCTGCCTAT TGCAGGACAATGATGGCTATTCTAAACGCTAAGGAAAAAAAACAAACACAGAACTGTTTCAAGTACTCAAGACTGACTTACAGACCAACC AACCACCTTGCTGGAACCCTTGCTAGCAGGCATTCTTATAAAAGAAACTTTCGAGCCTCCTTATATTGCTGGAAACTCAGCTGTGCTCCA GACTAGAGCCTCCTTACCTATGCTATGGATTTTTAATTTATTTTCTCTTATTTCATGTACACTGCTTTTTTTGGTTACAGTGTATGATGG ATGTGTATGAAAAAAATGTATCTTTGGGAAAACAATTACAGTTTGTTAATTTGAAGATGCTGGTCTTGACTCATCTTTATTTTTATTCGC ACATCCCACCCCATCCCCTGAACTACTTGGGAGGTGGGGAGGGGTACGAGTCCACTGTTGCTTTGGTAGAGATGAGAGGCCGCATTTTGC TGCTAAAGCAAGAGAAACTTGGAGCTGAAGCACACACCTGGTCTGCCCCTAGATTTCTCCTCAAGGCCTCTGGAGCAACCAGCACTTGCC CCCTTGGAATGCAGAGCCTGGCCTGCCAAACTACAATGTGGTAGGCTGAAACGATGGTGTTAATTCTTAGGACTACTTTTCTAGTCACAG ATGTTTTCAAATTTCTAAGAAAAAGAAAATGAGGCTCAAGAGGCTGCTTCGTAGAATTCCTTTTGAATGAATTGAGTGGGGATGGGGACA CAGTCTCCAAGTGTGTATGTGGTCTTTTCTGATCTCAGCTGTGTGGCTGCAACTCTTCGCTGTTCATTGGTTCCTCTCCTGGAAAGTGGC TTCTAACCAGCACTGGATGGTGATCATTGGTAAGCTTTGCTCACCTCCCTCTCTCTTGCTTCATTTGGCTTTATCAAAAAGAACAGACCT AGCTCTGAATTTGTTTGGCTTGGGAAATTATGGATTCTTTCAAGCCACTCCCACAAGGTGGGTCCTACTAGAAAGGGTTAGCATTTTAAG GGGGGTTGTTCTATACACCTGTGTCCTTACCCCAGGCTCAGGAACTGCCAGGGAGGGAAGATGAGGTGGGGAGTCTGTACTGAGATGGAA CTGTCAGTGCTGTGTTGTATGTACTTGCTGTTGTAAAAGTTTGGGCATGACTTTGCATCTAGCGGGTGCTGCCTGCATCTCTTTGTCTGT AAGCTTGCTCTGGGACTCAGCCTCTTAGGACCTACGATGCCAGCAGCTCTCATTAACAGTGAAATGACAGAGGCCAAAGATGGCCAAGTG AAGACCCAAGTCTCAGAAAACCCAGACTTGGGACAACTGCCTGGGAACTAGGATGCTAGAGCAGTTCTGTAATGCTTTGAGACACAGCAA TTTTCACATTGGCCATTCTTTCCCCTCCCCTACCCCTTTTCTTTTGAGGGACTTTTAATGTTTGCTGCTTTAGGTGGATGGAGAGTCCAC CAGTCCCACTCAATGCTGCTCTAACTCTACCCACACCCACCTAATTAGGGGTGCTAATAAAACATGCTGAGGTTGAGATAAAGACGGGAC ATAAGGGGAAAATTCATTCCATAGAGCTGAAATCTGGTTTTCAAGGCCTCTGTGGCTTTCTTCTGAACTTACCACCAGCCCTGGCTGGAA TGTAGATTGTGTTTTTAGTAATGTGTACTGTGAGCTGTCTTCTGTATAATGTATTTTGTAATGTATTTTTCTCATCTACCAAAGGATGAA >In-frame_ENST00000407071_ENST00000292211_TCGA-AJ-A3EM-01A_KIF26B_chr1_245583047_+_UBE2Q1_chr1_154524295_length(amino acids)=469AA_start in transcript=440_stop in transcript=1849 MNSVAGNKERLAVSTRGKKYGVNEVCSPTKPAAPFSPESWYRKAYEESRAGSRPTPEGAGSALGSSGTPSPGSGTSSPSSFTGSPGPASP GIGTSSPGSLGGSPGFGTGSPGSGSGGGSSPGSDRGVWCENCNARLVELKRQALRLLLPGPFPGKDPAFSAVIHDKLQVPNTIRKAWNDR DNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDASPCSPPPLSNIPTLVGSRHVGGLQQPRDWAFVPAPCATSNYTGFANKHGSKPSS LGVSNGAEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGTWSLSRTNGVTLYPYQISQLMTESSREGLTEAVLNRYNADKPS ACSVPASQGSCVASETSTGTSVAASFFARYVLGGGAICMELLTKQGWSSAYSIESVIMQISATLVKGKARVQFGANKSQYSLTRAQQSYK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KIF26B-UBE2Q1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KIF26B-UBE2Q1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KIF26B-UBE2Q1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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