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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLC2-SPARC (FusionGDB2 ID:42645)

Fusion Gene Summary for KLC2-SPARC

Fusion gene summary

Fusion gene information	Fusion gene name: KLC2-SPARC
	Fusion gene ID: 42645
		Hgene	Tgene
	Gene symbol	KLC2	SPARC
	Gene ID	147700	6678
	Gene name	kinesin light chain 3	secreted protein acidic and cysteine rich
	Synonyms	KLC2\|KLC2L\|KLCt\|KNS2B	BM-40\|OI17\|ON\|ONT
	Cytomap	19q13.32	5q33.1
	Type of gene	protein-coding	protein-coding
	Description	kinesin light chain 3kinesin light chain 2	SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin)
	Modification date	20200313	20200329
	UniProtAcc	.	SMAP2,SMOC2
	Ensembl transtripts involved in fusion gene	ENST00000417856, ENST00000394067, ENST00000421552, ENST00000316924, ENST00000394078, ENST00000394066, ENST00000394065,	ENST00000231061, ENST00000537849,
Fusion gene scores	* DoF score	1 X 1 X 1=1	34 X 31 X 7=7378
	# samples	1	38
	** MAII score	log2(1/1*10)=3.32192809488736	log2(38/7378*10)=-4.27915846536387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KLC2 [Title/Abstract] AND SPARC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLC2(66029278)-SPARC(151046064), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPARC	GO:0001937	negative regulation of endothelial cell proliferation	12867428
Tgene	SPARC	GO:0010595	positive regulation of endothelial cell migration	12867428
Tgene	SPARC	GO:0016525	negative regulation of angiogenesis	12867428
Tgene	SPARC	GO:0022604	regulation of cell morphogenesis	15389586

Fusion gene breakpoints across KLC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPARC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-14-1829-01A	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-

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Fusion Gene ORF analysis for KLC2-SPARC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000417856	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
5CDS-5UTR	ENST00000417856	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
In-frame	ENST00000394067	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
5CDS-5UTR	ENST00000394067	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
intron-3CDS	ENST00000421552	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
intron-5UTR	ENST00000421552	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
In-frame	ENST00000316924	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
5CDS-5UTR	ENST00000316924	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
In-frame	ENST00000394078	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
5CDS-5UTR	ENST00000394078	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
intron-3CDS	ENST00000394066	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
intron-5UTR	ENST00000394066	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
5UTR-3CDS	ENST00000394065	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-
5UTR-5UTR	ENST00000394065	ENST00000537849	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000417856	KLC2	chr11	66029278	+	ENST00000231061	SPARC	chr5	151046064	-	3438	636	1022	150	290
ENST00000394067	KLC2	chr11	66029278	+	ENST00000231061	SPARC	chr5	151046064	-	3375	573	959	0	320
ENST00000316924	KLC2	chr11	66029278	+	ENST00000231061	SPARC	chr5	151046064	-	3412	610	996	43	317
ENST00000394078	KLC2	chr11	66029278	+	ENST00000231061	SPARC	chr5	151046064	-	3359	557	943	2	314

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000417856	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-	0.001590635	0.99840945
ENST00000394067	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-	0.001570692	0.99842924
ENST00000316924	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-	0.00159084	0.9984092
ENST00000394078	ENST00000231061	KLC2	chr11	66029278	+	SPARC	chr5	151046064	-	0.001549042	0.998451

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Fusion Genomic Features for KLC2-SPARC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLC2-SPARC

Go to
FGviewer for the breakpoints of chr11:66029278-chr5:151046064
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	SPARC SMAP2,SMOC2
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	446

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPARC

chr11:66029278

chr5:151046064

ENST00000231061

274_285

195.0

304.0

Calcium binding

Tgene

SPARC

chr11:66029278

chr5:151046064

ENST00000231061

261_296

195.0

304.0

Domain

Note=EF-hand

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

78_143

623.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

78_143

546.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

78_143

623.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

78_143

623.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

78_143

546.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

198_231

623.0

Repeat

Note=TPR 1

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

240_273

623.0

Repeat

Note=TPR 2

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

282_315

623.0

Repeat

Note=TPR 3

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

324_357

623.0

Repeat

Note=TPR 4

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

366_399

623.0

Repeat

Note=TPR 5

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000316924

449_482

623.0

Repeat

Note=TPR 6

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

198_231

546.0

Repeat

Note=TPR 1

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

240_273

546.0

Repeat

Note=TPR 2

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

282_315

546.0

Repeat

Note=TPR 3

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

324_357

546.0

Repeat

Note=TPR 4

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

366_399

546.0

Repeat

Note=TPR 5

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394066

449_482

546.0

Repeat

Note=TPR 6

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

198_231

623.0

Repeat

Note=TPR 1

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

240_273

623.0

Repeat

Note=TPR 2

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

282_315

623.0

Repeat

Note=TPR 3

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

324_357

623.0

Repeat

Note=TPR 4

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

366_399

623.0

Repeat

Note=TPR 5

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000394067

449_482

623.0

Repeat

Note=TPR 6

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

198_231

623.0

Repeat

Note=TPR 1

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

240_273

623.0

Repeat

Note=TPR 2

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

282_315

623.0

Repeat

Note=TPR 3

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

324_357

623.0

Repeat

Note=TPR 4

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

366_399

623.0

Repeat

Note=TPR 5

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000417856

449_482

623.0

Repeat

Note=TPR 6

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

198_231

546.0

Repeat

Note=TPR 1

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

240_273

546.0

Repeat

Note=TPR 2

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

282_315

546.0

Repeat

Note=TPR 3

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

324_357

546.0

Repeat

Note=TPR 4

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

366_399

546.0

Repeat

Note=TPR 5

Hgene

KLC2

chr11:66029278

chr5:151046064

ENST00000421552

449_482

546.0

Repeat

Note=TPR 6

Tgene

SPARC

chr11:66029278

chr5:151046064

ENST00000231061

22_69

195.0

304.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B binds calcium)

Tgene

SPARC

chr11:66029278

chr5:151046064

ENST00000231061

71_93

195.0

304.0

Domain

Note=Follistatin-like

Tgene

SPARC

chr11:66029278

chr5:151046064

ENST00000231061

89_151

195.0

304.0

Domain

Kazal-like

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Fusion Gene Sequence for KLC2-SPARC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000417856_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(transcript)=3438nt_BP=636nt
GCGAGCCAGATAACAGCGGCACTCACTTCTCGGGTCTTCGTGAGCATTAAGTCAATGAACCCAGGGCACCAAAGCGCGCAACACGCAGTA
GGCGCTCAGTTAGTGGCGCCTCGCTCTGTACTCCAGGAAGCCCAACCTTCTCCCTGCGCCTCAGTTTCTCCCGACGTCCTCGATGGCGCC
ATGGCGCCACACTAGGCCCGGCGCCCGCCTGCCCGCACCCTCGTCCTCACAGACGCCACAGCCATGGCCATGATGGTGTTTCCGCGGGAG
GAGAAGCTGAGCCAGGATGAGATCGTGCTGGGCACCAAGGCTGTCATCCAGGGACTGGAGACTCTGCGTGGGGAGCATCGTGCCCTGCTG
GCTCCTCTGGTTGCACCTGAGGCCGGCGAAGCCGAGCCTGGCTCGCAGGAGCGCTGCATCCTCCTGCGTCGCTCCCTGGAAGCCATTGAG
CTTGGGCTGGGGGAGGCCCAGGTGCGGCGTCTGGTGCAGGAGAACCAGTGGCTGCGTGAGGAGCTGGCGGGGACACAGCAGAAGCTGCAG
CGCAGTGAGCAGGCCGTGGCCCAGCTCGAGGAGGAGAAGCAGCACTTGCTGTTCATGAGCCAGATCCGCAAGTTGGATGAAGACGCCTCC
CCTAACGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAAC
TATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCT
CCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTG
GATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTC
TCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGA
TTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTC
CACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGC
TCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTT
CATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATG
GTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAA
GATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTT
TTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCC
TCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATG
TAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTT
CCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAAC
TCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCA
AAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACAC
ATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACC
GGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCA
CTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATG
ATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGA
GTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATG
AGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAA
ATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACC
CTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGC
ACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCC
AAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAA
AACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTT
GGTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCAT
TGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCC
CCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAACGTGCTGTAAAGGAAATAAAGCA

>In-frame_ENST00000417856_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(amino acids)=290AA_start in transcript=1022_stop in transcript=150
MGETRRGGLKRESGTVEGVDLDHKILVDILLLDAEAAGPLIQGDVLVIVQVTGLEKAGGAMLHGDEGSTQWSQLGVGEVPVNGVLVQLAE
LPVYREDVHVIVLLEVPGQQLHGVVSCLQALLILMDLLHVRGGVFIQLADLAHEQQVLLLLLELGHGLLTALQLLLCPRQLLTQPLVLLH
QTPHLGLPQPKLNGFQGATQEDAALLRARLGFAGLRCNQRSQQGTMLPTQSLQSLDDSLGAQHDLILAQLLLPRKHHHGHGCGVCEDEGA

--------------------------------------------------------------
>In-frame_ENST00000394067_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(transcript)=3375nt_BP=573nt
GTGTTTCGCCCCCTCCGACGCCACCGAGGTAGCGGCTTCACCTTTAAGGCGGCGCGGGGGCTGCTGGGAAGGCCGGCGGGATGGAGGCGG
CGGGACCGGCTCGCGGGTGCGGGTCCGGGTGAAGCGGGAGGCAGCCAGAGTCGGAGCCGGGCCCGAGCACCAGGCGCAGACGCCACAGCC
ATGGCCATGATGGTGTTTCCGCGGGAGGAGAAGCTGAGCCAGGATGAGATCGTGCTGGGCACCAAGGCTGTCATCCAGGGACTGGAGACT
CTGCGTGGGGAGCATCGTGCCCTGCTGGCTCCTCTGGTTGCACCTGAGGCCGGCGAAGCCGAGCCTGGCTCGCAGGAGCGCTGCATCCTC
CTGCGTCGCTCCCTGGAAGCCATTGAGCTTGGGCTGGGGGAGGCCCAGGTGCGGCGTCTGGTGCAGGAGAACCAGTGGCTGCGTGAGGAG
CTGGCGGGGACACAGCAGAAGCTGCAGCGCAGTGAGCAGGCCGTGGCCCAGCTCGAGGAGGAGAAGCAGCACTTGCTGTTCATGAGCCAG
ATCCGCAAGTTGGATGAAGACGCCTCCCCTAACGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAG
CTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGAC
GGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGAC
CTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAA
ATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTC
TGCCTGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAG
CTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGC
ACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATAC
TTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGT
AACAGACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGG
TTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTC
CTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGT
CAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCC
AGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGA
TGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGG
GATGGTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCAT
GATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGT
CACCTTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTT
GCACACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAA
TGACCTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATT
CATTCATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGAC
AAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGT
GATGAAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACT
ACCCACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTT
GAGAGCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTC
TTCTAGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGAC
TCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCT
TATTTTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGG
CGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGA
GAGAGGAATTGAAGTAAATTTCAGCATTGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGA
GTAGGCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATA

>In-frame_ENST00000394067_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(amino acids)=320AA_start in transcript=959_stop in transcript=0
MGETRRGGLKRESGTVEGVDLDHKILVDILLLDAEAAGPLIQGDVLVIVQVTGLEKAGGAMLHGDEGSTQWSQLGVGEVPVNGVLVQLAE
LPVYREDVHVIVLLEVPGQQLHGVVSCLQALLILMDLLHVRGGVFIQLADLAHEQQVLLLLLELGHGLLTALQLLLCPRQLLTQPLVLLH
QTPHLGLPQPKLNGFQGATQEDAALLRARLGFAGLRCNQRSQQGTMLPTQSLQSLDDSLGAQHDLILAQLLLPRKHHHGHGCGVCAWCSG

--------------------------------------------------------------
>In-frame_ENST00000316924_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(transcript)=3412nt_BP=610nt
GTGTTTCGCCCCCTCCGACGCCACCGAGGTAGCGGCTTCACCTTTAAGGCGGCGCGGGGGCTGCTGGGAAGGCCGGCGGGATGGAGGCGG
CGGGACCGGCTCGCGGGTGCGGGTCCGGGTGAAGCGGGAGGCAGCCAGAGTCGGAGCCGGGCCCGAGCACCAGGCGCAGGCCCGGCGCCC
GCCTGCCCGCACCCTCGTCCTCACAGACGCCACAGCCATGGCCATGATGGTGTTTCCGCGGGAGGAGAAGCTGAGCCAGGATGAGATCGT
GCTGGGCACCAAGGCTGTCATCCAGGGACTGGAGACTCTGCGTGGGGAGCATCGTGCCCTGCTGGCTCCTCTGGTTGCACCTGAGGCCGG
CGAAGCCGAGCCTGGCTCGCAGGAGCGCTGCATCCTCCTGCGTCGCTCCCTGGAAGCCATTGAGCTTGGGCTGGGGGAGGCCCAGGTGCG
GCGTCTGGTGCAGGAGAACCAGTGGCTGCGTGAGGAGCTGGCGGGGACACAGCAGAAGCTGCAGCGCAGTGAGCAGGCCGTGGCCCAGCT
CGAGGAGGAGAAGCAGCACTTGCTGTTCATGAGCCAGATCCGCAAGTTGGATGAAGACGCCTCCCCTAACGTGAAGAAGATCCATGAGAA
TGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACA
CTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCAT
GGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCAT
CAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTT
CCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTA
AAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTC
TCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTT
CAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGG
GCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTG
GGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATA
TAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACT
TTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCT
TCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTG
GAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTT
TTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAA
AAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACT
GCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACT
ACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTAT
GGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACTG
AGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCA
TGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATG
ACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGCA
TTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACG
CAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATC
TTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCAT
CATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGC
CACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAA
ACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAG
CCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCATTGGCTCATTCAGTCATTCGGCGACAT
TCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAG

>In-frame_ENST00000316924_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(amino acids)=317AA_start in transcript=996_stop in transcript=43
MGETRRGGLKRESGTVEGVDLDHKILVDILLLDAEAAGPLIQGDVLVIVQVTGLEKAGGAMLHGDEGSTQWSQLGVGEVPVNGVLVQLAE
LPVYREDVHVIVLLEVPGQQLHGVVSCLQALLILMDLLHVRGGVFIQLADLAHEQQVLLLLLELGHGLLTALQLLLCPRQLLTQPLVLLH
QTPHLGLPQPKLNGFQGATQEDAALLRARLGFAGLRCNQRSQQGTMLPTQSLQSLDDSLGAQHDLILAQLLLPRKHHHGHGCGVCEDEGA

--------------------------------------------------------------
>In-frame_ENST00000394078_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(transcript)=3359nt_BP=557nt
GACGCCACCGAGGTAGCGGCTTCACCTTTAAGGCGGCGCGGGGGCTGCTGGGAAGGCCGGCGGGATGGAGGCGGCGGGACCGGCTCGCGG
GTGCGGGTCCGGGTGAAGCGGGAGGCAGCCAGAGTCGGAGCCGGGCCCGAGCACCAGGCGCAGACGCCACAGCCATGGCCATGATGGTGT
TTCCGCGGGAGGAGAAGCTGAGCCAGGATGAGATCGTGCTGGGCACCAAGGCTGTCATCCAGGGACTGGAGACTCTGCGTGGGGAGCATC
GTGCCCTGCTGGCTCCTCTGGTTGCACCTGAGGCCGGCGAAGCCGAGCCTGGCTCGCAGGAGCGCTGCATCCTCCTGCGTCGCTCCCTGG
AAGCCATTGAGCTTGGGCTGGGGGAGGCCCAGGTGCGGCGTCTGGTGCAGGAGAACCAGTGGCTGCGTGAGGAGCTGGCGGGGACACAGC
AGAAGCTGCAGCGCAGTGAGCAGGCCGTGGCCCAGCTCGAGGAGGAGAAGCAGCACTTGCTGTTCATGAGCCAGATCCGCAAGTTGGATG
AAGACGCCTCCCCTAACGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACT
TCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACA
CCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGT
ACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACA
GTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGT
GCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATT
AAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGG
ATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTT
TGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGT
TGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTA
ACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAG
TGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGG
GCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCA
AGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTT
TTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCAC
AGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCA
CAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGA
CACAAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGT
ACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAAC
CCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACA
AAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATT
TGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAG
GAGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTT
TTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGAT
TAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAA
GACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGA
GAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTT
AAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGA
TTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTA
AATTTCAGCATTGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTG
ATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAACGTGCTGTAAAG

>In-frame_ENST00000394078_ENST00000231061_TCGA-14-1829-01A_KLC2_chr11_66029278_+_SPARC_chr5_151046064_length(amino acids)=314AA_start in transcript=943_stop in transcript=2
MGETRRGGLKRESGTVEGVDLDHKILVDILLLDAEAAGPLIQGDVLVIVQVTGLEKAGGAMLHGDEGSTQWSQLGVGEVPVNGVLVQLAE
LPVYREDVHVIVLLEVPGQQLHGVVSCLQALLILMDLLHVRGGVFIQLADLAHEQQVLLLLLELGHGLLTALQLLLCPRQLLTQPLVLLH
QTPHLGLPQPKLNGFQGATQEDAALLRARLGFAGLRCNQRSQQGTMLPTQSLQSLDDSLGAQHDLILAQLLLPRKHHHGHGCGVCAWCSG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KLC2-SPARC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KLC2-SPARC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KLC2-SPARC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KLC2	C1836010	Spastic Paraplegia, Optic Atrophy, and Neuropathy	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	SPARC	C0023893	Liver Cirrhosis, Experimental	2	CTD_human
Tgene	SPARC	C0029434	Osteogenesis Imperfecta	2	CTD_human;GENOMICS_ENGLAND
Tgene	SPARC	C0007102	Malignant tumor of colon	1	CTD_human
Tgene	SPARC	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	SPARC	C0009402	Colorectal Carcinoma	1	CTD_human
Tgene	SPARC	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	SPARC	C0019158	Hepatitis	1	CTD_human
Tgene	SPARC	C0020429	Hyperalgesia	1	CTD_human
Tgene	SPARC	C0022658	Kidney Diseases	1	CTD_human
Tgene	SPARC	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Tgene	SPARC	C0023890	Liver Cirrhosis	1	CTD_human
Tgene	SPARC	C0023931	Lobstein Disease	1	CTD_human
Tgene	SPARC	C0024031	Low Back Pain	1	CTD_human
Tgene	SPARC	C0026764	Multiple Myeloma	1	CTD_human
Tgene	SPARC	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Tgene	SPARC	C0027540	Necrosis	1	CTD_human
Tgene	SPARC	C0027659	Neoplasms, Experimental	1	CTD_human
Tgene	SPARC	C0040034	Thrombocytopenia	1	CTD_human
Tgene	SPARC	C0041948	Uremia	1	CTD_human
Tgene	SPARC	C0043094	Weight Gain	1	CTD_human
Tgene	SPARC	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	SPARC	C0158266	Intervertebral Disc Degeneration	1	CTD_human
Tgene	SPARC	C0206686	Adrenocortical carcinoma	1	CTD_human
Tgene	SPARC	C0239946	Fibrosis, Liver	1	CTD_human
Tgene	SPARC	C0268363	Osteogenesis imperfecta type IV (disorder)	1	ORPHANET
Tgene	SPARC	C0423682	Low Back Pain, Mechanical	1	CTD_human
Tgene	SPARC	C0423689	Low Back Pain, Posterior Compartment	1	CTD_human
Tgene	SPARC	C0458247	Allodynia	1	CTD_human
Tgene	SPARC	C0577660	Low Back Pain, Postural	1	CTD_human
Tgene	SPARC	C0751211	Hyperalgesia, Primary	1	CTD_human
Tgene	SPARC	C0751212	Hyperalgesia, Secondary	1	CTD_human
Tgene	SPARC	C0751213	Tactile Allodynia	1	CTD_human
Tgene	SPARC	C0751214	Hyperalgesia, Thermal	1	CTD_human
Tgene	SPARC	C0751648	Recurrent Low Back Pain	1	CTD_human
Tgene	SPARC	C0919267	ovarian neoplasm	1	CTD_human
Tgene	SPARC	C1140680	Malignant neoplasm of ovary	1	CTD_human
Tgene	SPARC	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Tgene	SPARC	C2717759	Degenerative Intervertebral Discs	1	CTD_human
Tgene	SPARC	C2936719	Mechanical Allodynia	1	CTD_human
Tgene	SPARC	C4225301	OSTEOGENESIS IMPERFECTA, TYPE XVII	1	CTD_human;GENOMICS_ENGLAND;UNIPROT