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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLF5-TMC4 (FusionGDB2 ID:42687)

Fusion Gene Summary for KLF5-TMC4

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF5-TMC4
Fusion gene ID: 42687
HgeneTgene
Gene symbol

KLF5

TMC4

Gene ID

688

147798

Gene nameKruppel like factor 5transmembrane channel like 4
SynonymsBTEB2|CKLF|IKLF-
Cytomap

13q22.1

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 5(intestinal Kruppel-like factorBTE-binding protein 2GC box binding protein 2Klf5C isoformKruppel-like factor 5 (intestinal)basic transcription element binding protein 2colon krueppel-like factorcolon kruppel-like factorepiditransmembrane channel-like protein 4testicular tissue protein Li 204
Modification date2020031320200313
UniProtAcc

Q13887

.
Ensembl transtripts involved in fusion geneENST00000477333, ENST00000539231, 
ENST00000377687, 		ENST00000301187, 
ENST00000416963, ENST00000376591, 
ENST00000476013, 
Fusion gene scores* DoF score5 X 5 X 5=1253 X 3 X 1=9
# samples 73
** MAII scorelog2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KLF5 [Title/Abstract] AND TMC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLF5(73649913)-TMC4(54664070), # samples:1
Anticipated loss of major functional domain due to fusion event.KLF5-TMC4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
KLF5-TMC4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLF5

GO:0045944

positive regulation of transcription by RNA polymerase II

16595680

HgeneKLF5

GO:0099156

cell-cell signaling via exosome

28408180

HgeneKLF5

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

28408180


check buttonFusion gene breakpoints across KLF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN418033KLF5chr13

73649913

+TMC4chr19

54664070

-


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Fusion Gene ORF analysis for KLF5-TMC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000477333ENST00000301187KLF5chr13

73649913

+TMC4chr19

54664070

-
intron-3CDSENST00000477333ENST00000416963KLF5chr13

73649913

+TMC4chr19

54664070

-
intron-3CDSENST00000477333ENST00000376591KLF5chr13

73649913

+TMC4chr19

54664070

-
intron-intronENST00000477333ENST00000476013KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shiftENST00000539231ENST00000301187KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shiftENST00000539231ENST00000416963KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shiftENST00000539231ENST00000376591KLF5chr13

73649913

+TMC4chr19

54664070

-
5CDS-intronENST00000539231ENST00000476013KLF5chr13

73649913

+TMC4chr19

54664070

-
In-frameENST00000377687ENST00000301187KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shiftENST00000377687ENST00000416963KLF5chr13

73649913

+TMC4chr19

54664070

-
Frame-shiftENST00000377687ENST00000376591KLF5chr13

73649913

+TMC4chr19

54664070

-
5CDS-intronENST00000377687ENST00000476013KLF5chr13

73649913

+TMC4chr19

54664070

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377687KLF5chr1373649913+ENST00000301187TMC4chr1954664070-371934942871804505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377687ENST00000301187KLF5chr1373649913+TMC4chr1954664070-0.0016512850.9983487

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Fusion Genomic Features for KLF5-TMC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLF5-TMC4


check button Go to

FGviewer for the breakpoints of chr13:73649913-chr19:54664070

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLF5

Q13887

.
FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMC4chr13:73649913chr19:54664070ENST0000030118701563_670707.0Compositional biasNote=Poly-Glu
TgeneTMC4chr13:73649913chr19:54664070ENST0000037659101563_670713.0Compositional biasNote=Poly-Glu
TgeneTMC4chr13:73649913chr19:54664070ENST000004169630863_670.0295.0Compositional biasNote=Poly-Glu
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015190_2490707.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST000003011870151_1680707.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015271_3480707.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015370_3940707.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015416_4250707.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015447_4830707.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015505_5420707.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015566_5920707.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015614_6540707.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015678_7120707.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015190_2490713.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST000003765910151_1680713.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015271_3480713.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015370_3940713.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015416_4250713.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015447_4830713.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015505_5420713.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015566_5920713.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015614_6540713.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015678_7120713.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308190_2490.0295.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000416963081_1680.0295.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308271_3480.0295.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308370_3940.0295.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308416_4250.0295.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308447_4830.0295.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308505_5420.0295.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308566_5920.0295.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308614_6540.0295.0Topological domainExtracellular
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308678_7120.0295.0Topological domainCytoplasmic
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015169_1890707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015250_2700707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015349_3690707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015395_4150707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015426_4460707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015484_5040707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015543_5650707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015593_6130707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000301187015655_6770707.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015169_1890713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015250_2700713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015349_3690713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015395_4150713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015426_4460713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015484_5040713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015543_5650713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015593_6130713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST00000376591015655_6770713.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308169_1890.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308250_2700.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308349_3690.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308395_4150.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308426_4460.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308484_5040.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308543_5650.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308593_6130.0295.0TransmembraneHelical
TgeneTMC4chr13:73649913chr19:54664070ENST0000041696308655_6770.0295.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLF5chr13:73649913chr19:54664070ENST00000377687+14118_1260458.0Motif9aaTAD
HgeneKLF5chr13:73649913chr19:54664070ENST00000377687+14373_3970458.0Zinc fingerC2H2-type 1
HgeneKLF5chr13:73649913chr19:54664070ENST00000377687+14403_4270458.0Zinc fingerC2H2-type 2
HgeneKLF5chr13:73649913chr19:54664070ENST00000377687+14433_4550458.0Zinc fingerC2H2-type 3


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Fusion Gene Sequence for KLF5-TMC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000377687_ENST00000301187_CN418033_KLF5_chr13_73649913_+_TMC4_chr19_54664070_length(transcript)=3719nt_BP=3494nt
GCGGCCGCCCTGCGCGCGAAGCTCGTGGCCCGAGAGGGGTGCGGTCGGGCCGACGGAGGCGGGGCCCTGGCTGCCTCTCTCCCTGCTCAT
AGGCTGGCCGCTCAGGCCTGGCCGGCCTCGGGGCCTCGGGATTCGCGGCGGCGCTGCCAATCAGGCGATCGGGCCCCGCCCCCCCGGAGT
TGGGTGAAATAGAGGCGGGCGTCAAGTGTCAGTAGTCGCGGGGCAGGTACGTGCGCTCGCGGTTCTCTCGCGGAGGTCGGCGGTGGCGGG
AGCGGGCTCCGGAGAGCCTGAGAGCACGGTGGGGCGGGGCGGGAGAAAGTGGCCGCCCGGAGGACGTTGGCGTTTACGTGTGGAAGAGCG
GAAGAGTTTTGCTTTTCGTGCGCGCCTTCGAAAACTGCCTGCCGCTGTCTGAGGAGTCCACCCGAAACCTCCCCTCCTCCGCCGGCAGCC
CCGCGCTGAGCTCGCCGACCCAAGCCAGCGTGGGCGAGGTGGGAAGTGCGCCCGACCCGCGCCTGGAGCTGCGCCCCCGAGTGCCCATGG
CTACAAGGGTGCTGAGCATGAGCGCCCGCCTGGGACCCGTGCCCCAGCCGCCGGCGCCGCAGGACGAGCCGGTGTTCGCGCAGCTCAAGC
CGGTGCTGGGCGCCGCGAATCCGGCCCGCGACGCGGCGCTCTTCCCCGGCGAGGAGCTGAAGCACGCGCACCACCGCCCGCAGGCGCAGC
CCGCGCCCGCGCAGGCCCCGCAGCCGGCCCAGCCGCCCGCCACCGGCCCGCGGCTGCCTCCAGAGGACCTGGTCCAGACAAGATGTGAAA
TGGAGAAGTATCTGACACCTCAGCTTCCTCCAGTTCCTATAATTCCAGAGCATAAAAAGTATAGACGAGACAGTGCCTCAGTCGTAGACC
AGTTCTTCACTGACACTGAAGGGTTACCTTACAGTATCAACATGAACGTCTTCCTCCCTGACATCACTCACCTGAGAACTGGCCTCTACA
AATCCCAGAGACCGTGCGTAACACACATCAAGACAGAACCTGTTGCCATTTTCAGCCACCAGAGTGAAACGACTGCCCCTCCTCCGGCCC
CGACCCAGGCCCTCCCTGAGTTCACCAGTATATTCAGCTCACACCAGACCGCAGCTCCAGAGGTGAACAATATTTTCATCAAACAAGAAC
TTCCTACACCAGATCTTCATCTTTCTGTCCCTACCCAGCAGGGCCACCTGTACCAGCTACTGAATACACCGGATCTAGATATGCCCAGTT
CTACAAATCAGACAGCAGCAATGGACACTCTTAATGTTTCTATGTCAGCTGCCATGGCAGGCCTTAACACACACACCTCTGCTGTTCCGC
AGACTGCAGTGAAACAATTCCAGGGCATGCCCCCTTGCACATACACAATGCCAAGTCAGTTTCTTCCACAACAGGCCACTTACTTTCCCC
CGTCACCACCAAGCTCAGAGCCTGGAAGTCCAGATAGACAAGCAGAGATGCTCCAGAATTTAACCCCACCTCCATCCTATGCTGCTACAA
TTGCTTCTAAACTGGCAATTCACAATCCAAATTTACCCACCACCCTGCCAGTTAACTCACAAAACATCCAACCTGTCAGATACAATAGAA
GGAGTAACCCCGATTTGGAGAAACGACGCATCCACTACTGCGATTACCCTGGTTGCACAAAAGTTTATACCAAGTCTTCTCATTTAAAAG
CTCACCTGAGGACTCACACTGCGCCACTACCGGAAGCACACAGGCGCCAAGCCCTTCCAGTGCGGGGTGTGCAACCGCAGCTTCTCGCGC
TCTGACCACCTGGCCCTGCATATGAAGAGGCACCAGAACTGAGCACTGCCCGTGTGACCCGTTCCAGGTCCCCTGGGCTCCCTCAAATGA
CAGACCTAACTATTCCTGTGTAAAAACAACAAAAACAAACAAAAGCAAGAAAACCACAACTAAAACTGGAAATGTATATTTTGTATATTT
GAGAAAACAGGGAATACATTGTATTAATACCAAAGTGTTTGGTCATTTTAAGAATCTGGAATGCTTGCTGTAATGTATATGGCTTTACTC
AAGCAGATCTCATCTCATGACAGGCAGCCACGTCTCAACATGGGTAAGGGGTGGGGGTGGAGGGGAGTGTGTGCAGCGTTTTTACCTAGG
CACCATCATTTAATGTGACAGTGTTCAGTAAACAAATCAGTTGGCAGGCACCAGAAGAAGAATGGATTGTATGTCAAGATTTTACTTGGC
ATTGAGTAGTTTTTTTCAATAGTAGGTAATTCCTTAGAGATACAGTATACCTGGCAATTCACAAATAGCCATTGAACAAATGTGTGGGTT
TTTAAAAATTATATACATATATGAGTTGCCTATATTTGCTATTCAAAATTTTGTAAATATGCAAATCAGCTTTATAGGTTTATTACAAGT
TTTTTAGGATTCTTTTGGGGAAGAGTCATAATTCTTTTGAAAATAACCATGAATACACTTACAGTTAGGATTTGTGGTAAGGTACCTCTC
AACATTACCAAAATCATTTCTTTAGAGGGAAGGAATAATCATTCAAATGAACTTTAAAAAAGCAAATTTCATGCACTGATTAAAATAGGA
TTATTTTAAATACAAAAGGCATTTTATATGAATTATAAACTGAAGAGCTTAAAGATAGTTACAAAATACAAAAGTTCAACCTCTTACAAT
AAGCTAAACGCAATGTCATTTTTAAAAAGAAGGACTTAGGGTGTCGTTTTCACATATGACAATGTTGCATTTATGATGCAGTTTCAAGTA
CCAAAACGTTGAATTGATGATGCAGTTTTCATATATCGAGATGTTCGCTCGTGCAGTACTGTTGGTTAAATGACAATTTATGTGGATTTT
GCATGTAATACACAGTGAGACACAGTAATTTTATCTAAATTACAGTGCAGTTTAGTTAATCTATTAATACTGACTCAGTGTCTGCCTTTA
AATATAAATGATATGTTGAAAACTTAAGGAAGCAAATGCTACATATATGCAATATAAAATAGTAATGTGATGCTGATGCTGTTAACCAAA
GGGCAGAATAAATAAGCAAAATGCCAAAAGGGGTCTTAATTGAAATGAAAATTTAATTTTGTTTTTAAAATATTGTTTATCTTTATTTAT
TTTGTGGTAATATAGTAAGTTTTTTTAGAAGACAATTTTCATAACTTGATAAATTATAGTTTTGTTTGTTAGAAAAGTTGCTCTTAAAAG
ATGTAAATAGATGACAAACGATGTAAATAATTTTGTAAGAGGCTTCAAAATGTTTATACGTGGAAACACACCTACATGAAAAGCAGAAAT
CGGTTGCTGTTTTGCTTCTTTTTCCCTCTTATTTTTGTATTGTGGTCATTTCCTATGCAAATAATGGAGCAAACAGCTGTATAGTTGTAG
AATTTTTTGAGAGAATGAGATGTTTATATATTAACGACAATTTTTTTTTTGGAAAATAAAAAGTGCCTAAAAGAGCTGACCTCCACCAAA
CCGGCTCTTTGACCCCCGCAGCCCACGTCCCGCTTTCAGACCCCAGGCCCATTGTAAGCCTAGGTCACAACATCTGTAAACTAGGAGAAC
TGGAGAAGACTCCACGCCCTTCCAGCTTTGGTATCTGGAGATTTCCAGGGCCCCTCGCCGCCACGTCCTGACTCTCGGGTGATCTTCCTT

>In-frame_ENST00000377687_ENST00000301187_CN418033_KLF5_chr13_73649913_+_TMC4_chr19_54664070_length(amino acids)=505AA_start in transcript=287_stop in transcript=1804
MRARWGGAGESGRPEDVGVYVWKSGRVLLFVRAFENCLPLSEESTRNLPSSAGSPALSSPTQASVGEVGSAPDPRLELRPRVPMATRVLS
MSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLT
PQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALP
EFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQ
FQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDL

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Fusion Gene PPI Analysis for KLF5-TMC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLF5-TMC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLF5-TMC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKLF5C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneKLF5C0005695Bladder Neoplasm1CTD_human
HgeneKLF5C0007137Squamous cell carcinoma1CTD_human
HgeneKLF5C0009402Colorectal Carcinoma1CTD_human;UNIPROT
HgeneKLF5C0009404Colorectal Neoplasms1CTD_human
HgeneKLF5C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneKLF5C0030297Pancreatic Neoplasm1CTD_human
HgeneKLF5C0036341Schizophrenia1PSYGENET
HgeneKLF5C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneKLF5C0346647Malignant neoplasm of pancreas1CTD_human
HgeneKLF5C1527303Chronic Airflow Obstruction1CTD_human
HgeneKLF5C2936380Neointima1CTD_human
HgeneKLF5C2936381Neointima Formation1CTD_human