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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2A-EPS15 (FusionGDB2 ID:42951)

Fusion Gene Summary for KMT2A-EPS15

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2A-EPS15
Fusion gene ID: 42951
HgeneTgene
Gene symbol

KMT2A

EPS15

Gene ID

4297

2060

Gene namelysine methyltransferase 2Aepidermal growth factor receptor pathway substrate 15
SynonymsALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTSAF-1P|AF1P|MLLT5
Cytomap

11q23.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-likeepidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p
Modification date2020031920200313
UniProtAcc

Q03164

Q9UBC2

Ensembl transtripts involved in fusion geneENST00000534358, ENST00000389506, 
ENST00000354520, ENST00000420751, 
ENST00000371730, ENST00000371733, 
ENST00000396122, ENST00000493793, 
Fusion gene scores* DoF score79 X 196 X 13=20129211 X 14 X 5=770
# samples 24114
** MAII scorelog2(241/201292*10)=-6.38411287931608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/770*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2A [Title/Abstract] AND EPS15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2A(118355690)-EPS15(51946988), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

HgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

HgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

HgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

HgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

HgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722

TgeneEPS15

GO:0048268

clathrin coat assembly

12807910


check buttonFusion gene breakpoints across KMT2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EPS15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAY187922KMT2Achr11

118355690

+EPS15chr1

51946988

-


Top

Fusion Gene ORF analysis for KMT2A-EPS15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000534358ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51946988

-
In-frameENST00000534358ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51946988

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51946988

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51946988

-
In-frameENST00000389506ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51946988

-
In-frameENST00000389506ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51946988

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51946988

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-3CDSENST00000354520ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-3CDSENST00000354520ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-intronENST00000354520ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-intronENST00000354520ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-3CDSENST00000420751ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-3CDSENST00000420751ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-intronENST00000420751ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51946988

-
intron-intronENST00000420751ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51946988

-
3UTR-3CDSENST00000420751ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51912777

-
3UTR-3CDSENST00000420751ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51912777

-
3UTR-intronENST00000420751ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51984995

-
3UTR-intronENST00000420751ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51984995

-
3UTR-intronENST00000420751ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51912777

-
3UTR-intronENST00000420751ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51984995

-
3UTR-intronENST00000420751ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51912777

-
3UTR-intronENST00000420751ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000354520ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000354520ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000354520ENST00000396122KMT2Achr11

118348916

+EPS15chr1

51930998

-
5CDS-intronENST00000354520ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51912777

-
5CDS-intronENST00000354520ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51946986

-
5CDS-intronENST00000354520ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51912777

-
5CDS-intronENST00000354520ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000354520ENST00000493793KMT2Achr11

118348916

+EPS15chr1

51930998

-
5CDS-intronENST00000354520ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51912777

-
5CDS-intronENST00000354520ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51946986

-
5CDS-intronENST00000354520ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51912777

-
5CDS-intronENST00000354520ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000389506ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000389506ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118348916

+EPS15chr1

51930998

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51912777

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51946986

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51912777

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000389506ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51906104

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118348916

+EPS15chr1

51930998

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51912777

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51946986

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51912777

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000389506ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51906104

-
5CDS-intronENST00000534358ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000534358ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118348916

+EPS15chr1

51930998

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51912777

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51946986

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51912777

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000534358ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51906104

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118348916

+EPS15chr1

51930998

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51912777

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51946986

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51912777

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118355029

+EPS15chr1

51984995

-
5CDS-intronENST00000534358ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51906104

-
Frame-shiftENST00000354520ENST00000371730KMT2Achr11

118348916

+EPS15chr1

51930998

-
Frame-shiftENST00000354520ENST00000371733KMT2Achr11

118348916

+EPS15chr1

51930998

-
Frame-shiftENST00000389506ENST00000371730KMT2Achr11

118348916

+EPS15chr1

51930998

-
Frame-shiftENST00000389506ENST00000371733KMT2Achr11

118348916

+EPS15chr1

51930998

-
Frame-shiftENST00000534358ENST00000371730KMT2Achr11

118348916

+EPS15chr1

51930998

-
Frame-shiftENST00000534358ENST00000371733KMT2Achr11

118348916

+EPS15chr1

51930998

-
In-frameENST00000354520ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51912777

-
In-frameENST00000354520ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51946986

-
In-frameENST00000354520ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51912777

-
In-frameENST00000354520ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51912777

-
In-frameENST00000354520ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51946986

-
In-frameENST00000354520ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51912777

-
In-frameENST00000389506ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51912777

-
In-frameENST00000389506ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51946986

-
In-frameENST00000389506ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51912777

-
In-frameENST00000389506ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51906104

-
In-frameENST00000389506ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51912777

-
In-frameENST00000389506ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51946986

-
In-frameENST00000389506ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51912777

-
In-frameENST00000389506ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51906104

-
In-frameENST00000534358ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51912777

-
In-frameENST00000534358ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51946986

-
In-frameENST00000534358ENST00000371730KMT2Achr11

118355029

+EPS15chr1

51912777

-
In-frameENST00000534358ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51906104

-
In-frameENST00000534358ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51912777

-
In-frameENST00000534358ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51946986

-
In-frameENST00000534358ENST00000371733KMT2Achr11

118355029

+EPS15chr1

51912777

-
In-frameENST00000534358ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-3CDSENST00000354520ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-3CDSENST00000354520ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-3CDSENST00000420751ENST00000371730KMT2Achr11

118348916

+EPS15chr1

51930998

-
intron-3CDSENST00000420751ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51912777

-
intron-3CDSENST00000420751ENST00000371730KMT2Achr11

118353210

+EPS15chr1

51946986

-
intron-3CDSENST00000420751ENST00000371730KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-3CDSENST00000420751ENST00000371733KMT2Achr11

118348916

+EPS15chr1

51930998

-
intron-3CDSENST00000420751ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51912777

-
intron-3CDSENST00000420751ENST00000371733KMT2Achr11

118353210

+EPS15chr1

51946986

-
intron-3CDSENST00000420751ENST00000371733KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-intronENST00000354520ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-intronENST00000354520ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-intronENST00000420751ENST00000396122KMT2Achr11

118348916

+EPS15chr1

51930998

-
intron-intronENST00000420751ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51912777

-
intron-intronENST00000420751ENST00000396122KMT2Achr11

118353210

+EPS15chr1

51946986

-
intron-intronENST00000420751ENST00000396122KMT2Achr11

118355690

+EPS15chr1

51906104

-
intron-intronENST00000420751ENST00000493793KMT2Achr11

118348916

+EPS15chr1

51930998

-
intron-intronENST00000420751ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51912777

-
intron-intronENST00000420751ENST00000493793KMT2Achr11

118353210

+EPS15chr1

51946986

-
intron-intronENST00000420751ENST00000493793KMT2Achr11

118355690

+EPS15chr1

51906104

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534358KMT2Achr11118355690+ENST00000371730EPS15chr151946988-904843552366102195
ENST00000534358KMT2Achr11118355690+ENST00000371733EPS15chr151946988-945043552370122329
ENST00000389506KMT2Achr11118355690+ENST00000371730EPS15chr151946988-90254332065872195
ENST00000389506KMT2Achr11118355690+ENST00000371733EPS15chr151946988-94274332069892329

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534358ENST00000371730KMT2Achr11118355690+EPS15chr151946988-0.0002214010.99977857
ENST00000534358ENST00000371733KMT2Achr11118355690+EPS15chr151946988-0.0001765270.9998235
ENST00000389506ENST00000371730KMT2Achr11118355690+EPS15chr151946988-0.0002157960.9997842
ENST00000389506ENST00000371733KMT2Achr11118355690+EPS15chr151946988-0.0001722360.99982774

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Fusion Genomic Features for KMT2A-EPS15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KMT2A-EPS15


check button Go to

FGviewer for the breakpoints of chr11:118355690-chr1:51946988

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2A

Q03164

EPS15

Q9UBC2

FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036137_1431444.03970.0Compositional biasNote=Poly-Gly
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+103617_1021444.03970.0Compositional biasNote=Ala/Gly/Ser-rich
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036561_5641444.03970.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036568_5711444.03970.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036137_1431444.03973.0Compositional biasNote=Poly-Gly
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+103617_1021444.03973.0Compositional biasNote=Ala/Gly/Ser-rich
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036561_5641444.03973.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036568_5711444.03973.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036169_1801444.03970.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036217_2271444.03970.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036301_3091444.03970.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036169_1801444.03973.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036217_2271444.03973.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036301_3091444.03973.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036123_1341444.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+1036147_1521444.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10366_251444.03970.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036123_1341444.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+1036147_1521444.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10366_251444.03973.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361147_11951444.03970.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361147_11951444.03973.0Zinc fingerCXXC-type
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025173_18411.0897.0Calcium bindingNote=1
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025236_24711.0897.0Calcium bindingNote=2
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025768_85011.0897.0Compositional biasNote=Pro-rich
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025128_21611.0897.0DomainEH 2
TgeneEPS15chr11:118355690chr1:51946988ENST0000037173302515_10411.0897.0DomainEH 1
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025160_19511.0897.0DomainEF-hand 1
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025223_25811.0897.0DomainEF-hand 2
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025224_31411.0897.0DomainEH 3
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025851_87011.0897.0DomainUIM 1
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025877_89611.0897.0DomainUIM 2
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025768_77411.0897.0MotifNote=SH3-binding
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025599_82711.0897.0RegionNote=15 X 3 AA repeats of D-P-F
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025599_60111.0897.0RepeatNote=1
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025623_62511.0897.0RepeatNote=2
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025629_63111.0897.0RepeatNote=3
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025634_63611.0897.0RepeatNote=4
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025640_64211.0897.0RepeatNote=5
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025645_64711.0897.0RepeatNote=6
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025651_65311.0897.0RepeatNote=7
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025664_66611.0897.0RepeatNote=8
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025672_67411.0897.0RepeatNote=9
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025692_69411.0897.0RepeatNote=10
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025709_71111.0897.0RepeatNote=11
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025737_73911.0897.0RepeatNote=12
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025798_80011.0897.0RepeatNote=13
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025804_80611.0897.0RepeatNote=14
TgeneEPS15chr11:118355690chr1:51946988ENST00000371733025825_82711.0897.0RepeatNote=15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135137_1430.03932.0Compositional biasNote=Poly-Gly
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+13517_1020.03932.0Compositional biasNote=Ala/Gly/Ser-rich
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135561_5640.03932.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135568_5710.03932.0Compositional biasNote=Poly-Pro
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135169_1800.03932.0DNA bindingNote=A.T hook 1
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135217_2270.03932.0DNA bindingNote=A.T hook 2
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135301_3090.03932.0DNA bindingNote=A.T hook 3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351703_17480.03932.0DomainBromo%3B divergent
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1352018_20740.03932.0DomainFYR N-terminal
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1353666_37470.03932.0DomainFYR C-terminal
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1353829_39450.03932.0DomainSET
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1353953_39690.03932.0DomainPost-SET
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361703_17481444.03970.0DomainBromo%3B divergent
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10362018_20741444.03970.0DomainFYR N-terminal
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10363666_37471444.03970.0DomainFYR C-terminal
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10363829_39451444.03970.0DomainSET
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10363953_39691444.03970.0DomainPost-SET
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361703_17481444.03973.0DomainBromo%3B divergent
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10362018_20741444.03973.0DomainFYR N-terminal
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10363666_37471444.03973.0DomainFYR C-terminal
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10363829_39451444.03973.0DomainSET
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10363953_39691444.03973.0DomainPost-SET
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135123_1340.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+135147_1520.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1356_250.03932.0MotifMenin-binding motif (MBM)
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1353906_39070.03932.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10363906_39071444.03970.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10363906_39071444.03973.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351147_11950.03932.0Zinc fingerCXXC-type
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351431_14820.03932.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351479_15330.03932.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351566_16270.03932.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351870_19100.03932.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351931_19780.03932.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361431_14821444.03970.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361479_15331444.03970.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361566_16271444.03970.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361870_19101444.03970.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361931_19781444.03970.0Zinc fingerPHD-type 4
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361431_14821444.03973.0Zinc fingerPHD-type 1
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361479_15331444.03973.0Zinc fingerPHD-type 2
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361566_16271444.03973.0Zinc fingerPHD-type 3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361870_19101444.03973.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361931_19781444.03973.0Zinc fingerPHD-type 4


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Fusion Gene Sequence for KMT2A-EPS15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000534358_ENST00000371730_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(transcript)=9048nt_BP=4355nt
CTGCTTCACTTCACGGGGCGAACATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGG
GGCGCCGGGGCCTAGGGGGCGCCCCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGG
CGCCCCCCTCCCCCCCGGCTGTGGCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAG
CAGCCTCCTCGTCGTCCGCCTCGTCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCG
ACGCGGCGCTGCAGGTCTCGGCCGCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCG
GAGAGGATGAGCAATTCTTAGGTTTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTC
GAAAACCTCGTGGGAGACCTAGAAGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAG
AGACCAAATCTGGAGATAAGATCAAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAA
TCAAAATAACACATGGAAAGGACATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTA
CGTTTCAGCAAGCCACAAAGATTAAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAG
GAAGGAAGGGGGTACAAATTGTACGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTG
AACTGGAAAAGCCCCAGAAAGTCCGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTC
GAAGGATTAAGCCAGTTAGGATTATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGG
CTCAAAAGAAAATTGAAAAAGAAGCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTG
TTGTCAGTGCTATCTCCTCGCGGATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGAT
TAGAGTCTACACCGAATAGTAGATTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGT
CTTCAGACTCCTCTCGATCTAGTAGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGC
GGAGCGATACCCCTGAAGTTCATCCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAG
TGTCGGAGAGAAGTTTTGGATCTAGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTC
CACCTCTGCTGACTCCACCGCCACCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAG
CATCACCATTTTTGCCTGCTTCCACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAA
AGCATTCTAGGTCAGAGCCACAATACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGAC
CCCCTCCACTAACTCCCGAGGACGTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCC
ATTCTGGAACAAGGTTTGATATGCACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTG
AGTCTGTAACCTTGCCTAGTAATCGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTC
CTATTCGATCTGAACCAAGATCTCCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCC
CGTCTTCTGTCTCTTCCTCGTTAAGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCC
TGACTCAGTCTGGGGAATCTGCAGAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTA
CTCCTCTCTTCCCTTGGTTTACCCCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAG
ATGCTGACAAGAGCGTGGAGAAGGACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAA
GGAAAAAGGGATCAGAAATTCAGAGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCA
CTTCATCTTCTGCCAAAAAAGCAACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATA
CAACAGCTGTCAAAACCAAAATACTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCC
TGGAGAAGGAGAAAACCCTCTGCCTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGG
CAGACAAGCTTCCAATGACTGACAAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTC
TTAAACAAACCGACCAGCCCAAAGCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCA
GAAGAGCAGCTGTTGCCCTTGGCCGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAA
AGATTTTGTCTTCCATGGGGAATGATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTA
AACCTGTCACTAGAAACAAGGCACCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGG
TGCCTGAGGACTGTGGTGTTTGTACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAA
AATGTCAGAATCTACAATGGATGCCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCA
GTGAAAAGAAAGACAGCAAAGAGAGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTG
CCCCAAAGAAAAGCAGTAGTGAGCCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAAT
CCAAACAGGCCACCACTCCAGCTTCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAG
GACCGCCAAGAAAAGAAGTTCCCAAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCA
AACAGAAAAAAGTGGCTCCCCGCCCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGA
ATGCAGGCACTTTGAACATCCTCAGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAG
TGGACTTTAAGGAGGATTGTGAAGCAGAAAATGTGTGGGAGATGGGAGGCTTAGGAATCTTGACTTCTGTTCCTATAACACCCAGGGTGG
TTTGCTTTCTCTGTGCCAGTAGTGGGCATGTAGAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATACAGGCA
ATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGATTTAG
CCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGAAGTTT
CACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTCATGATACCAGTAGTCCTTTGCTAATCAGTGGAACCTCTGCAGCTGAGC
TCCCATGGGCTGTAAAACCTGAAGATAAGGCCAAATATGATGCAATATTTGATAGTTTAAGCCCAGTGAATGGATTTCTGTCTGGTGATA
AAGTGAAACCAGTGTTGCTCAACTCTAAGTTACCTGTGGATATCCTTGGAAGAGTTTGGGAGTTGAGTGATATTGACCATGATGGAATGC
TTGACAGAGATGAGTTTGCAGTTGCCATGTTTTTGGTATACTGTGCACTGGAGAAAGAACCTGTGCCAATGTCCTTGCCTCCAGCCTTGG
TGCCACCATCTAAGAGAAAAACGTGGGTTGTATCCCCTGCAGAAAAAGCTAAATATGATGAAATCTTCCTGAAAACTGATAAAGATATGG
ACGGATTTGTGTCTGGATTGGAGGTCCGTGAAATATTCTTGAAAACAGGTTTACCTTCTACCTTACTAGCCCATATATGGTCATTATGCG
ACACAAAGGACTGTGGGAAGCTTTCAAAGGATCAGTTTGCCTTGGCTTTTCACTTAATCAGTCAGAAGTTAATCAAGGGCATTGATCCTC
CTCACGTTCTTACTCCTGAAATGATTCCACCATCAGACAGGGCCAGTTTACAAAAGAACATCATAGGATCAAGTCCTGTTGCAGATTTCT
CTGCTATTAAGGAACTAGATACTCTTAACAATGAAATAGTTGACCTACAGAGGGAAAAGAATAATGTGGAACAGGACCTTAAGGAGAAGG
AAGATACTATTAAACAGAGGACAAGTGAGGTTCAGGATCTTCAAGATGAAGTTCAAAGGGAGAATACTAATCTGCAAAAACTACAGGCCC
AGAAACAGCAGGTACAGGAACTCCTTGATGAACTGGATGAGCAGAAAGCCCAGCTGGAGGAGCAACTCAAGGAAGTCAGAAAGAAATGTG
CTGAGGAGGCCCAACTGGCAAGAAGTAGTCCTGAACTACTGCCTTCTGGTGTGACTGATGAAAATGAGGTGACTACAGCTGTTACTGAAA
AAGTTTGTTCTGAACTCGACAATAATAGACATTCAAAAGAGGAAGATCCATTTAATGTAGACTCAAGTTCGCTGACAGGTCCAGTTGCAG
ATACAAACTTGGATTTTTTCCAGTCTGATCCTTTTGTTGGCAGTGATCCTTTCAAGGATGATCCTTTTGGAAAAATCGATCCATTTGGTG
GTGATCCTTTCAAAGGTTCAGATCCATTTGCATCAGACTGTTTCTTCAGGCAATCTACTGATCCTTTTGCCACTTCAAGCACTGACCCTT
TCAGTGCAGCCAACAATAGCAGTATTACATCGGTAGAAACGTTGAAGCACAATGATCCTTTTGCTCCTGGTGGAACAGTTGTTGCAGCAA
GCGATTCAGCCACAGACCCCTTTGCTTCTGTTTTTGGGAATGAATCATTTGGAGGTGGATTTGCTGACTTCAGCACATTGTCAAAGGTCA
ACAATGAAGATCCTTTTCGTTCAGCCACATCGAGCTCTGTCAGCAACGTAGTGATTACAAAAAATGTATTTGAGGAAACATCGGTCAAAA
GTGAAGATGAACCCCCAGCACTGCCACCAAAGATCGGAACTCCAACAAGACCCTGCCCTCTACCACCTGGGAAAAGATCCATCAACAAAT
TGGATTCTCCTGATCCCTTTAAACTGAATGATCCATTTCAGCCTTTCCCAGGCAACGATAGCCCCAAAGAAAAAGATCCTGAAATATTTT
GTGATCCATTCACTTCTGCTACTACCACTACCAATAAAGAGGCTGATCCAAGCAATTTTGCCAACTTCAGTGCTTATCCCTCTGAAGAAG
ATATGATCGAATGGGCCAAGAGGGAAAGTGAGAGAGAGGAAGAGCAGAGGCTTGCCCGACTAAATCAGCAGGAACAAGAAGACTTAGAAC
TGGCTATTGCACTCAGCAAATCTGAGATATCAGAAGCATGAAGAATTCTCTTGTTCTTTGGCAACAATATAGTATTCTTCTTCCTGAATA
CTGAAACTATTTACAATGTGTATCAAAACTACCTGTGAGCATGGGAATACAAAAGGTTTGAGATTCCTGTAAATGTGACAAAATTTTAGG
ATTTTTTTTTTTTCTTCATTACAGATTCGTCTTTTTTTTTTTTTCTTATAAAAGCCGTAACCCAGTCAGACAAATTCACCTTCACTTAGG
CCCCTGTTCTGGTATACATTTACTGTGAGCTTTTGCCTGCCTGTGCTATTTTACTTGTAAAGCTAGAGCACCCAAGCTTCTGCCTTCTGG
AATATAGAGAAATAGTTTCACCCTGCACTACCCTGTTCTGTAGTTATTCTGATGATAGCCAGTGAGGTTCTTAAAGTTTGCAGTATTCTC
CCCTGATTGGAATGGTTGAGTGAGGGTAAGGGAAAGAATATCTTATTTCTTTTATGATTGGTGCAAATTGGCTAAAGTGCATTTTTAAAT
TTCCTCTACTTAATTTGTTTTTCAGAGATAAGGAAAAATATTTTGCACAGATTTACTCCACTATGGAAAAGGGATGCTGTAGGTTGAACC
ATTATAGCCTCAGATTCGATCTTTTCCTAACTAAAAATATTAAAGCCTCATGTGTGAAATAAATTTTTAAAAAGATTTATCTGGATTTAG
AGAATTTTAGATCAACAGATACCTCTCAGTGTGTTTGCTAATTAATAAAAATCAGTTTCTTACAAATAAAGTTTGTAAGAAAATGTTCAT
TTTAAGTGATAGATAGTGGAGAAAATTTATCACCTAAAATATACCCATCAGTATAAGGCAAGCAAAAGTCTTAACATGGCAGCCATTCTG
CCTTTGCCGTGGCCCTGTCCTGTTTAGTTCTTAGTGGGTTAATTTTTGTACTTTTGCAGAAGAAACTTCAGCAAGCTAGAACTGGAAGGT
ACTTTAATTTTTCATATATATTTGTTTTTTTTTTTTTAATGAAGGCTCATTTACTTGAAATGTAAAAACTTTCACTGAATACAAATAGAA
AAAGTGATGTGTTTTATATCATATTGCTTTTTGTCCATCTTTGTGGTTTAGTTTATTTACTCACTTCATGTTTTTCACCTATAAAATTGT
CAAGCTAGCAAAAAAACTCTTGTTTTTTTAATTGGGAGAGAAGAGACCTGCCAGATTATCAGACCTCTTCATGTTAAAAGACCATCTCCT
GTAAAACTGACCTAGTGGACAAGCTGAATTTGAAATAGACTGTGAAGTAAGCTGTAACTTGTCATTTTAATTTTGTTTAACACGGTTACT
GACTTAGATGATGTATTAAATACCAAGATAAAGAAAAATGCACCTAAAATCTAATTAGAATTCTCTGGGTCAACAAGTCAAGGTGGTATT
GATCTGTGTTAATCTGAGTAACTTATTGCCTAGCCTATAAATAAATTCCAAAATATCCAATTCATTTCTTCTTGAAATGGTGCTTGTTTT
GTTTTCTTTCCATTACACAATTAGACTCCTACAGTTTAAAACAAACTTTAAACCACTATCTTGCACTGCTAACTTTTTTCTACCTTTGTA
AATAGAAACATTTCTGCATAAAAGTCATACATATGAAGCAAGGGCTGAATCATAATCACAAGGCTTAATTTTGATAAACGAATCCAGTGA
CCTAAGGATTTTCTGCAAAATTTGACTGGGAGTTGTGATAGGTGGTATTTTTGTTTATTTTCTTCCTCTTACTCCTTAGGATAAAGGTAA
GTTGACTTGAACAACTTTCTTTTGCACTGGGAAAATAAGCAAATGTTTAAATGCTTCAAAAAAATTTTCAATTAAACTCAAATATTAAAT
ATCTATAACTTATAAACACCAACTTTCAATGTAATAAATGTATCCTAATCTTATGTATGTTTAACTGGATTACATAGATTTTTATCTTTT
GTTAAAATGTGTATACCCCGTGGACCAACATAATATTAAAGTATGTATATATTATATAAATATATATGTATATGTGCTCGCTTGTGTAGG
ATGAATGTCTTAGAGTCGTTTGTGGTATTTTATGTTGTTGACTCTGGCTCCAGGGCCTGTGCTTGAAAAGGACAGATAAGTATTGCCCAG
AGCTAAGTGGCACTACTTACAAAGTTTTAAATGTCTTCTACATACTGATTCATGTTTATTTGAGCTCTCTTTATAGAATTTTCTCTTAAA
GTTTCAAACCTCTAAGTTGTAGCCTGTAATTATGAGAACAGTAAACTTTAAGTAATAATAAAGAATCCCATCCATATATCCAATTTGCAA
TTGAGTTTTGCATGGTTCTCTGATTATGTCCATGCTGTGTCCAAGGAGGAGTAGGTACATACAATCAGCACAGATTAATATATGTAAAGG

>In-frame_ENST00000534358_ENST00000371730_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(amino acids)=2195AA_start in transcript=23_stop in transcript=6610
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLA
VPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAV
AMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL
SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRT
SEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLARSSPELLPSGVTDENEVTTAVTEKVCSELDN
NRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSS
ITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPAL
PPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKR

--------------------------------------------------------------
>In-frame_ENST00000534358_ENST00000371733_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(transcript)=9450nt_BP=4355nt
CTGCTTCACTTCACGGGGCGAACATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGG
GGCGCCGGGGCCTAGGGGGCGCCCCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGG
CGCCCCCCTCCCCCCCGGCTGTGGCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAG
CAGCCTCCTCGTCGTCCGCCTCGTCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCG
ACGCGGCGCTGCAGGTCTCGGCCGCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCG
GAGAGGATGAGCAATTCTTAGGTTTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTC
GAAAACCTCGTGGGAGACCTAGAAGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAG
AGACCAAATCTGGAGATAAGATCAAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAA
TCAAAATAACACATGGAAAGGACATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTA
CGTTTCAGCAAGCCACAAAGATTAAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAG
GAAGGAAGGGGGTACAAATTGTACGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTG
AACTGGAAAAGCCCCAGAAAGTCCGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTC
GAAGGATTAAGCCAGTTAGGATTATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGG
CTCAAAAGAAAATTGAAAAAGAAGCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTG
TTGTCAGTGCTATCTCCTCGCGGATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGAT
TAGAGTCTACACCGAATAGTAGATTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGT
CTTCAGACTCCTCTCGATCTAGTAGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGC
GGAGCGATACCCCTGAAGTTCATCCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAG
TGTCGGAGAGAAGTTTTGGATCTAGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTC
CACCTCTGCTGACTCCACCGCCACCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAG
CATCACCATTTTTGCCTGCTTCCACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAA
AGCATTCTAGGTCAGAGCCACAATACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGAC
CCCCTCCACTAACTCCCGAGGACGTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCC
ATTCTGGAACAAGGTTTGATATGCACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTG
AGTCTGTAACCTTGCCTAGTAATCGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTC
CTATTCGATCTGAACCAAGATCTCCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCC
CGTCTTCTGTCTCTTCCTCGTTAAGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCC
TGACTCAGTCTGGGGAATCTGCAGAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTA
CTCCTCTCTTCCCTTGGTTTACCCCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAG
ATGCTGACAAGAGCGTGGAGAAGGACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAA
GGAAAAAGGGATCAGAAATTCAGAGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCA
CTTCATCTTCTGCCAAAAAAGCAACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATA
CAACAGCTGTCAAAACCAAAATACTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCC
TGGAGAAGGAGAAAACCCTCTGCCTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGG
CAGACAAGCTTCCAATGACTGACAAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTC
TTAAACAAACCGACCAGCCCAAAGCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCA
GAAGAGCAGCTGTTGCCCTTGGCCGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAA
AGATTTTGTCTTCCATGGGGAATGATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTA
AACCTGTCACTAGAAACAAGGCACCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGG
TGCCTGAGGACTGTGGTGTTTGTACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAA
AATGTCAGAATCTACAATGGATGCCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCA
GTGAAAAGAAAGACAGCAAAGAGAGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTG
CCCCAAAGAAAAGCAGTAGTGAGCCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAAT
CCAAACAGGCCACCACTCCAGCTTCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAG
GACCGCCAAGAAAAGAAGTTCCCAAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCA
AACAGAAAAAAGTGGCTCCCCGCCCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGA
ATGCAGGCACTTTGAACATCCTCAGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAG
TGGACTTTAAGGAGGATTGTGAAGCAGAAAATGTGTGGGAGATGGGAGGCTTAGGAATCTTGACTTCTGTTCCTATAACACCCAGGGTGG
TTTGCTTTCTCTGTGCCAGTAGTGGGCATGTAGAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATACAGGCA
ATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGATTTAG
CCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGAAGTTT
CACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTCATGATACCAGTAGTCCTTTGCTAATCAGTGGAACCTCTGCAGCTGAGC
TCCCATGGGCTGTAAAACCTGAAGATAAGGCCAAATATGATGCAATATTTGATAGTTTAAGCCCAGTGAATGGATTTCTGTCTGGTGATA
AAGTGAAACCAGTGTTGCTCAACTCTAAGTTACCTGTGGATATCCTTGGAAGAGTTTGGGAGTTGAGTGATATTGACCATGATGGAATGC
TTGACAGAGATGAGTTTGCAGTTGCCATGTTTTTGGTATACTGTGCACTGGAGAAAGAACCTGTGCCAATGTCCTTGCCTCCAGCCTTGG
TGCCACCATCTAAGAGAAAAACGTGGGTTGTATCCCCTGCAGAAAAAGCTAAATATGATGAAATCTTCCTGAAAACTGATAAAGATATGG
ACGGATTTGTGTCTGGATTGGAGGTCCGTGAAATATTCTTGAAAACAGGTTTACCTTCTACCTTACTAGCCCATATATGGTCATTATGCG
ACACAAAGGACTGTGGGAAGCTTTCAAAGGATCAGTTTGCCTTGGCTTTTCACTTAATCAGTCAGAAGTTAATCAAGGGCATTGATCCTC
CTCACGTTCTTACTCCTGAAATGATTCCACCATCAGACAGGGCCAGTTTACAAAAGAACATCATAGGATCAAGTCCTGTTGCAGATTTCT
CTGCTATTAAGGAACTAGATACTCTTAACAATGAAATAGTTGACCTACAGAGGGAAAAGAATAATGTGGAACAGGACCTTAAGGAGAAGG
AAGATACTATTAAACAGAGGACAAGTGAGGTTCAGGATCTTCAAGATGAAGTTCAAAGGGAGAATACTAATCTGCAAAAACTACAGGCCC
AGAAACAGCAGGTACAGGAACTCCTTGATGAACTGGATGAGCAGAAAGCCCAGCTGGAGGAGCAACTCAAGGAAGTCAGAAAGAAATGTG
CTGAGGAGGCCCAACTGATCTCTTCTCTGAAAGCTGAATTAACTAGTCAGGAATCGCAGATCTCCACTTACGAAGAAGAATTGGCAAAAG
CTAGAGAAGAGCTGAGCCGTCTACAGCAAGAAACAGCAGAATTGGAGGAGAGTGTAGAGTCAGGGAAGGCTCAGTTGGAACCTCTTCAGC
AGCACCTACAAGATTCACAACAGGAAATTAGTTCAATGCAAATGAAACTGATGGAAATGAAAGATTTGGAAAATCATAATAGTCAGTTAA
ATTGGTGCAGTAGCCCACACAGCATTCTTGTAAACGGAGCTACAGATTATTGCAGCCTCAGCACCAGCAGCAGTGAAACAGCCAACCTTA
ATGAACATGTTGAAGGCCAGAGCAACCTAGAGTCTGAGCCCATACACCAGGAATCTCCAGCAAGAAGTAGTCCTGAACTACTGCCTTCTG
GTGTGACTGATGAAAATGAGGTGACTACAGCTGTTACTGAAAAAGTTTGTTCTGAACTCGACAATAATAGACATTCAAAAGAGGAAGATC
CATTTAATGTAGACTCAAGTTCGCTGACAGGTCCAGTTGCAGATACAAACTTGGATTTTTTCCAGTCTGATCCTTTTGTTGGCAGTGATC
CTTTCAAGGATGATCCTTTTGGAAAAATCGATCCATTTGGTGGTGATCCTTTCAAAGGTTCAGATCCATTTGCATCAGACTGTTTCTTCA
GGCAATCTACTGATCCTTTTGCCACTTCAAGCACTGACCCTTTCAGTGCAGCCAACAATAGCAGTATTACATCGGTAGAAACGTTGAAGC
ACAATGATCCTTTTGCTCCTGGTGGAACAGTTGTTGCAGCAAGCGATTCAGCCACAGACCCCTTTGCTTCTGTTTTTGGGAATGAATCAT
TTGGAGGTGGATTTGCTGACTTCAGCACATTGTCAAAGGTCAACAATGAAGATCCTTTTCGTTCAGCCACATCGAGCTCTGTCAGCAACG
TAGTGATTACAAAAAATGTATTTGAGGAAACATCGGTCAAAAGTGAAGATGAACCCCCAGCACTGCCACCAAAGATCGGAACTCCAACAA
GACCCTGCCCTCTACCACCTGGGAAAAGATCCATCAACAAATTGGATTCTCCTGATCCCTTTAAACTGAATGATCCATTTCAGCCTTTCC
CAGGCAACGATAGCCCCAAAGAAAAAGATCCTGAAATATTTTGTGATCCATTCACTTCTGCTACTACCACTACCAATAAAGAGGCTGATC
CAAGCAATTTTGCCAACTTCAGTGCTTATCCCTCTGAAGAAGATATGATCGAATGGGCCAAGAGGGAAAGTGAGAGAGAGGAAGAGCAGA
GGCTTGCCCGACTAAATCAGCAGGAACAAGAAGACTTAGAACTGGCTATTGCACTCAGCAAATCTGAGATATCAGAAGCATGAAGAATTC
TCTTGTTCTTTGGCAACAATATAGTATTCTTCTTCCTGAATACTGAAACTATTTACAATGTGTATCAAAACTACCTGTGAGCATGGGAAT
ACAAAAGGTTTGAGATTCCTGTAAATGTGACAAAATTTTAGGATTTTTTTTTTTTCTTCATTACAGATTCGTCTTTTTTTTTTTTTCTTA
TAAAAGCCGTAACCCAGTCAGACAAATTCACCTTCACTTAGGCCCCTGTTCTGGTATACATTTACTGTGAGCTTTTGCCTGCCTGTGCTA
TTTTACTTGTAAAGCTAGAGCACCCAAGCTTCTGCCTTCTGGAATATAGAGAAATAGTTTCACCCTGCACTACCCTGTTCTGTAGTTATT
CTGATGATAGCCAGTGAGGTTCTTAAAGTTTGCAGTATTCTCCCCTGATTGGAATGGTTGAGTGAGGGTAAGGGAAAGAATATCTTATTT
CTTTTATGATTGGTGCAAATTGGCTAAAGTGCATTTTTAAATTTCCTCTACTTAATTTGTTTTTCAGAGATAAGGAAAAATATTTTGCAC
AGATTTACTCCACTATGGAAAAGGGATGCTGTAGGTTGAACCATTATAGCCTCAGATTCGATCTTTTCCTAACTAAAAATATTAAAGCCT
CATGTGTGAAATAAATTTTTAAAAAGATTTATCTGGATTTAGAGAATTTTAGATCAACAGATACCTCTCAGTGTGTTTGCTAATTAATAA
AAATCAGTTTCTTACAAATAAAGTTTGTAAGAAAATGTTCATTTTAAGTGATAGATAGTGGAGAAAATTTATCACCTAAAATATACCCAT
CAGTATAAGGCAAGCAAAAGTCTTAACATGGCAGCCATTCTGCCTTTGCCGTGGCCCTGTCCTGTTTAGTTCTTAGTGGGTTAATTTTTG
TACTTTTGCAGAAGAAACTTCAGCAAGCTAGAACTGGAAGGTACTTTAATTTTTCATATATATTTGTTTTTTTTTTTTTAATGAAGGCTC
ATTTACTTGAAATGTAAAAACTTTCACTGAATACAAATAGAAAAAGTGATGTGTTTTATATCATATTGCTTTTTGTCCATCTTTGTGGTT
TAGTTTATTTACTCACTTCATGTTTTTCACCTATAAAATTGTCAAGCTAGCAAAAAAACTCTTGTTTTTTTAATTGGGAGAGAAGAGACC
TGCCAGATTATCAGACCTCTTCATGTTAAAAGACCATCTCCTGTAAAACTGACCTAGTGGACAAGCTGAATTTGAAATAGACTGTGAAGT
AAGCTGTAACTTGTCATTTTAATTTTGTTTAACACGGTTACTGACTTAGATGATGTATTAAATACCAAGATAAAGAAAAATGCACCTAAA
ATCTAATTAGAATTCTCTGGGTCAACAAGTCAAGGTGGTATTGATCTGTGTTAATCTGAGTAACTTATTGCCTAGCCTATAAATAAATTC
CAAAATATCCAATTCATTTCTTCTTGAAATGGTGCTTGTTTTGTTTTCTTTCCATTACACAATTAGACTCCTACAGTTTAAAACAAACTT
TAAACCACTATCTTGCACTGCTAACTTTTTTCTACCTTTGTAAATAGAAACATTTCTGCATAAAAGTCATACATATGAAGCAAGGGCTGA
ATCATAATCACAAGGCTTAATTTTGATAAACGAATCCAGTGACCTAAGGATTTTCTGCAAAATTTGACTGGGAGTTGTGATAGGTGGTAT
TTTTGTTTATTTTCTTCCTCTTACTCCTTAGGATAAAGGTAAGTTGACTTGAACAACTTTCTTTTGCACTGGGAAAATAAGCAAATGTTT
AAATGCTTCAAAAAAATTTTCAATTAAACTCAAATATTAAATATCTATAACTTATAAACACCAACTTTCAATGTAATAAATGTATCCTAA
TCTTATGTATGTTTAACTGGATTACATAGATTTTTATCTTTTGTTAAAATGTGTATACCCCGTGGACCAACATAATATTAAAGTATGTAT
ATATTATATAAATATATATGTATATGTGCTCGCTTGTGTAGGATGAATGTCTTAGAGTCGTTTGTGGTATTTTATGTTGTTGACTCTGGC
TCCAGGGCCTGTGCTTGAAAAGGACAGATAAGTATTGCCCAGAGCTAAGTGGCACTACTTACAAAGTTTTAAATGTCTTCTACATACTGA
TTCATGTTTATTTGAGCTCTCTTTATAGAATTTTCTCTTAAAGTTTCAAACCTCTAAGTTGTAGCCTGTAATTATGAGAACAGTAAACTT
TAAGTAATAATAAAGAATCCCATCCATATATCCAATTTGCAATTGAGTTTTGCATGGTTCTCTGATTATGTCCATGCTGTGTCCAAGGAG
GAGTAGGTACATACAATCAGCACAGATTAATATATGTAAAGGGTTTGGGACAGCACCTGGTATAGAATAAATAATAAATGTAAACTATTA

>In-frame_ENST00000534358_ENST00000371733_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(amino acids)=2329AA_start in transcript=23_stop in transcript=7012
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLA
VPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAV
AMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL
SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRT
SEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL
QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQS
NLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFG
KIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADF
STLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKE

--------------------------------------------------------------
>In-frame_ENST00000389506_ENST00000371730_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(transcript)=9025nt_BP=4332nt
ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC
CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG
GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG
TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC
GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT
TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA
AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC
AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC
ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT
AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA
CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC
CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT
ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA
GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG
ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA
TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT
AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT
CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT
AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA
CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC
ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA
TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC
GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG
CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT
CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT
CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA
AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA
GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC
CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG
GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG
AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA
ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA
CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC
CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC
AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA
GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC
CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT
GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA
CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT
ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG
CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG
AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG
CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT
TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC
AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC
CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC
AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAGGATTGTGAA
GCAGAAAATGTGTGGGAGATGGGAGGCTTAGGAATCTTGACTTCTGTTCCTATAACACCCAGGGTGGTTTGCTTTCTCTGTGCCAGTAGT
GGGCATGTAGAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATACAGGCAATACTGGAAGGGTGTTGGCTTCT
GATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGATTTAGCCGACACAGATGGCAAAGGTATC
CTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGAAGTTTCACTAAGTAGTTTGAACCTGGCT
GTTCCTCCACCAAGATTTCATGATACCAGTAGTCCTTTGCTAATCAGTGGAACCTCTGCAGCTGAGCTCCCATGGGCTGTAAAACCTGAA
GATAAGGCCAAATATGATGCAATATTTGATAGTTTAAGCCCAGTGAATGGATTTCTGTCTGGTGATAAAGTGAAACCAGTGTTGCTCAAC
TCTAAGTTACCTGTGGATATCCTTGGAAGAGTTTGGGAGTTGAGTGATATTGACCATGATGGAATGCTTGACAGAGATGAGTTTGCAGTT
GCCATGTTTTTGGTATACTGTGCACTGGAGAAAGAACCTGTGCCAATGTCCTTGCCTCCAGCCTTGGTGCCACCATCTAAGAGAAAAACG
TGGGTTGTATCCCCTGCAGAAAAAGCTAAATATGATGAAATCTTCCTGAAAACTGATAAAGATATGGACGGATTTGTGTCTGGATTGGAG
GTCCGTGAAATATTCTTGAAAACAGGTTTACCTTCTACCTTACTAGCCCATATATGGTCATTATGCGACACAAAGGACTGTGGGAAGCTT
TCAAAGGATCAGTTTGCCTTGGCTTTTCACTTAATCAGTCAGAAGTTAATCAAGGGCATTGATCCTCCTCACGTTCTTACTCCTGAAATG
ATTCCACCATCAGACAGGGCCAGTTTACAAAAGAACATCATAGGATCAAGTCCTGTTGCAGATTTCTCTGCTATTAAGGAACTAGATACT
CTTAACAATGAAATAGTTGACCTACAGAGGGAAAAGAATAATGTGGAACAGGACCTTAAGGAGAAGGAAGATACTATTAAACAGAGGACA
AGTGAGGTTCAGGATCTTCAAGATGAAGTTCAAAGGGAGAATACTAATCTGCAAAAACTACAGGCCCAGAAACAGCAGGTACAGGAACTC
CTTGATGAACTGGATGAGCAGAAAGCCCAGCTGGAGGAGCAACTCAAGGAAGTCAGAAAGAAATGTGCTGAGGAGGCCCAACTGGCAAGA
AGTAGTCCTGAACTACTGCCTTCTGGTGTGACTGATGAAAATGAGGTGACTACAGCTGTTACTGAAAAAGTTTGTTCTGAACTCGACAAT
AATAGACATTCAAAAGAGGAAGATCCATTTAATGTAGACTCAAGTTCGCTGACAGGTCCAGTTGCAGATACAAACTTGGATTTTTTCCAG
TCTGATCCTTTTGTTGGCAGTGATCCTTTCAAGGATGATCCTTTTGGAAAAATCGATCCATTTGGTGGTGATCCTTTCAAAGGTTCAGAT
CCATTTGCATCAGACTGTTTCTTCAGGCAATCTACTGATCCTTTTGCCACTTCAAGCACTGACCCTTTCAGTGCAGCCAACAATAGCAGT
ATTACATCGGTAGAAACGTTGAAGCACAATGATCCTTTTGCTCCTGGTGGAACAGTTGTTGCAGCAAGCGATTCAGCCACAGACCCCTTT
GCTTCTGTTTTTGGGAATGAATCATTTGGAGGTGGATTTGCTGACTTCAGCACATTGTCAAAGGTCAACAATGAAGATCCTTTTCGTTCA
GCCACATCGAGCTCTGTCAGCAACGTAGTGATTACAAAAAATGTATTTGAGGAAACATCGGTCAAAAGTGAAGATGAACCCCCAGCACTG
CCACCAAAGATCGGAACTCCAACAAGACCCTGCCCTCTACCACCTGGGAAAAGATCCATCAACAAATTGGATTCTCCTGATCCCTTTAAA
CTGAATGATCCATTTCAGCCTTTCCCAGGCAACGATAGCCCCAAAGAAAAAGATCCTGAAATATTTTGTGATCCATTCACTTCTGCTACT
ACCACTACCAATAAAGAGGCTGATCCAAGCAATTTTGCCAACTTCAGTGCTTATCCCTCTGAAGAAGATATGATCGAATGGGCCAAGAGG
GAAAGTGAGAGAGAGGAAGAGCAGAGGCTTGCCCGACTAAATCAGCAGGAACAAGAAGACTTAGAACTGGCTATTGCACTCAGCAAATCT
GAGATATCAGAAGCATGAAGAATTCTCTTGTTCTTTGGCAACAATATAGTATTCTTCTTCCTGAATACTGAAACTATTTACAATGTGTAT
CAAAACTACCTGTGAGCATGGGAATACAAAAGGTTTGAGATTCCTGTAAATGTGACAAAATTTTAGGATTTTTTTTTTTTCTTCATTACA
GATTCGTCTTTTTTTTTTTTTCTTATAAAAGCCGTAACCCAGTCAGACAAATTCACCTTCACTTAGGCCCCTGTTCTGGTATACATTTAC
TGTGAGCTTTTGCCTGCCTGTGCTATTTTACTTGTAAAGCTAGAGCACCCAAGCTTCTGCCTTCTGGAATATAGAGAAATAGTTTCACCC
TGCACTACCCTGTTCTGTAGTTATTCTGATGATAGCCAGTGAGGTTCTTAAAGTTTGCAGTATTCTCCCCTGATTGGAATGGTTGAGTGA
GGGTAAGGGAAAGAATATCTTATTTCTTTTATGATTGGTGCAAATTGGCTAAAGTGCATTTTTAAATTTCCTCTACTTAATTTGTTTTTC
AGAGATAAGGAAAAATATTTTGCACAGATTTACTCCACTATGGAAAAGGGATGCTGTAGGTTGAACCATTATAGCCTCAGATTCGATCTT
TTCCTAACTAAAAATATTAAAGCCTCATGTGTGAAATAAATTTTTAAAAAGATTTATCTGGATTTAGAGAATTTTAGATCAACAGATACC
TCTCAGTGTGTTTGCTAATTAATAAAAATCAGTTTCTTACAAATAAAGTTTGTAAGAAAATGTTCATTTTAAGTGATAGATAGTGGAGAA
AATTTATCACCTAAAATATACCCATCAGTATAAGGCAAGCAAAAGTCTTAACATGGCAGCCATTCTGCCTTTGCCGTGGCCCTGTCCTGT
TTAGTTCTTAGTGGGTTAATTTTTGTACTTTTGCAGAAGAAACTTCAGCAAGCTAGAACTGGAAGGTACTTTAATTTTTCATATATATTT
GTTTTTTTTTTTTTAATGAAGGCTCATTTACTTGAAATGTAAAAACTTTCACTGAATACAAATAGAAAAAGTGATGTGTTTTATATCATA
TTGCTTTTTGTCCATCTTTGTGGTTTAGTTTATTTACTCACTTCATGTTTTTCACCTATAAAATTGTCAAGCTAGCAAAAAAACTCTTGT
TTTTTTAATTGGGAGAGAAGAGACCTGCCAGATTATCAGACCTCTTCATGTTAAAAGACCATCTCCTGTAAAACTGACCTAGTGGACAAG
CTGAATTTGAAATAGACTGTGAAGTAAGCTGTAACTTGTCATTTTAATTTTGTTTAACACGGTTACTGACTTAGATGATGTATTAAATAC
CAAGATAAAGAAAAATGCACCTAAAATCTAATTAGAATTCTCTGGGTCAACAAGTCAAGGTGGTATTGATCTGTGTTAATCTGAGTAACT
TATTGCCTAGCCTATAAATAAATTCCAAAATATCCAATTCATTTCTTCTTGAAATGGTGCTTGTTTTGTTTTCTTTCCATTACACAATTA
GACTCCTACAGTTTAAAACAAACTTTAAACCACTATCTTGCACTGCTAACTTTTTTCTACCTTTGTAAATAGAAACATTTCTGCATAAAA
GTCATACATATGAAGCAAGGGCTGAATCATAATCACAAGGCTTAATTTTGATAAACGAATCCAGTGACCTAAGGATTTTCTGCAAAATTT
GACTGGGAGTTGTGATAGGTGGTATTTTTGTTTATTTTCTTCCTCTTACTCCTTAGGATAAAGGTAAGTTGACTTGAACAACTTTCTTTT
GCACTGGGAAAATAAGCAAATGTTTAAATGCTTCAAAAAAATTTTCAATTAAACTCAAATATTAAATATCTATAACTTATAAACACCAAC
TTTCAATGTAATAAATGTATCCTAATCTTATGTATGTTTAACTGGATTACATAGATTTTTATCTTTTGTTAAAATGTGTATACCCCGTGG
ACCAACATAATATTAAAGTATGTATATATTATATAAATATATATGTATATGTGCTCGCTTGTGTAGGATGAATGTCTTAGAGTCGTTTGT
GGTATTTTATGTTGTTGACTCTGGCTCCAGGGCCTGTGCTTGAAAAGGACAGATAAGTATTGCCCAGAGCTAAGTGGCACTACTTACAAA
GTTTTAAATGTCTTCTACATACTGATTCATGTTTATTTGAGCTCTCTTTATAGAATTTTCTCTTAAAGTTTCAAACCTCTAAGTTGTAGC
CTGTAATTATGAGAACAGTAAACTTTAAGTAATAATAAAGAATCCCATCCATATATCCAATTTGCAATTGAGTTTTGCATGGTTCTCTGA
TTATGTCCATGCTGTGTCCAAGGAGGAGTAGGTACATACAATCAGCACAGATTAATATATGTAAAGGGTTTGGGACAGCACCTGGTATAG

>In-frame_ENST00000389506_ENST00000371730_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(amino acids)=2195AA_start in transcript=0_stop in transcript=6587
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLA
VPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAV
AMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL
SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRT
SEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLARSSPELLPSGVTDENEVTTAVTEKVCSELDN
NRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSS
ITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPAL
PPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKR

--------------------------------------------------------------
>In-frame_ENST00000389506_ENST00000371733_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(transcript)=9427nt_BP=4332nt
ATGGCGCACAGCTGTCGGTGGCGCTTCCCCGCCCGACCCGGGACCACCGGGGGCGGCGGCGGCGGGGGGCGCCGGGGCCTAGGGGGCGCC
CCGCGGCAACGCGTCCCGGCCCTGCTGCTTCCCCCCGGGCCCCCGGTCGGCGGTGGCGGCCCCGGGGCGCCCCCCTCCCCCCCGGCTGTG
GCGGCCGCGGCGGCGGCGGCGGGAAGCAGCGGGGCTGGGGTTCCAGGGGGAGCGGCCGCCGCCTCAGCAGCCTCCTCGTCGTCCGCCTCG
TCTTCGTCTTCGTCATCGTCCTCAGCCTCTTCAGGGCCGGCCCTGCTCCGGGTGGGCCCGGGCTTCGACGCGGCGCTGCAGGTCTCGGCC
GCCATCGGCACCAACCTGCGCCGGTTCCGGGCCGTGTTTGGGGAGAGCGGCGGGGGAGGCGGCAGCGGAGAGGATGAGCAATTCTTAGGT
TTTGGCTCAGATGAAGAAGTCAGAGTGCGAAGTCCCACAAGGTCTCCTTCAGTTAAAACTAGTCCTCGAAAACCTCGTGGGAGACCTAGA
AGTGGCTCTGACCGAAATTCAGCTATCCTCTCAGATCCATCTGTGTTTTCCCCTCTAAATAAATCAGAGACCAAATCTGGAGATAAGATC
AAGAAGAAAGATTCTAAAAGTATAGAAAAGAAGAGAGGAAGACCTCCCACCTTCCCTGGAGTAAAAATCAAAATAACACATGGAAAGGAC
ATTTCAGAGTTACCAAAGGGAAACAAAGAAGATAGCCTGAAAAAAATTAAAAGGACACCTTCTGCTACGTTTCAGCAAGCCACAAAGATT
AAAAAATTAAGAGCAGGTAAACTCTCTCCTCTCAAGTCTAAGTTTAAGACAGGGAAGCTTCAAATAGGAAGGAAGGGGGTACAAATTGTA
CGACGGAGAGGAAGGCCTCCATCAACAGAAAGGATAAAGACCCCTTCGGGTCTCCTCATTAATTCTGAACTGGAAAAGCCCCAGAAAGTC
CGGAAAGACAAGGAAGGAACACCTCCACTTACAAAAGAAGATAAGACAGTTGTCAGACAAAGCCCTCGAAGGATTAAGCCAGTTAGGATT
ATTCCTTCTTCAAAAAGGACAGATGCAACCATTGCTAAGCAACTCTTACAGAGGGCAAAAAAGGGGGCTCAAAAGAAAATTGAAAAAGAA
GCAGCTCAGCTGCAGGGAAGAAAGGTGAAGACACAGGTCAAAAATATTCGACAGTTCATCATGCCTGTTGTCAGTGCTATCTCCTCGCGG
ATCATTAAGACCCCTCGGCGGTTTATAGAGGATGAGGATTATGACCCTCCAATTAAAATTGCCCGATTAGAGTCTACACCGAATAGTAGA
TTCAGTGCCCCGTCCTGTGGATCTTCTGAAAAATCAAGTGCAGCTTCTCAGCACTCCTCTCAAATGTCTTCAGACTCCTCTCGATCTAGT
AGCCCCAGTGTTGATACCTCCACAGACTCTCAGGCTTCTGAGGAGATTCAGGTACTTCCTGAGGAGCGGAGCGATACCCCTGAAGTTCAT
CCTCCACTGCCCATTTCCCAGTCCCCAGAAAATGAGAGTAATGATAGGAGAAGCAGAAGGTATTCAGTGTCGGAGAGAAGTTTTGGATCT
AGAACGACGAAAAAATTATCAACTCTACAAAGTGCCCCCCAGCAGCAGACCTCCTCGTCTCCACCTCCACCTCTGCTGACTCCACCGCCA
CCACTGCAGCCAGCCTCCAGTATCTCTGACCACACACCTTGGCTTATGCCTCCAACAATCCCCTTAGCATCACCATTTTTGCCTGCTTCC
ACTGCTCCTATGCAAGGGAAGCGAAAATCTATTTTGCGAGAACCGACATTTAGGTGGACTTCTTTAAAGCATTCTAGGTCAGAGCCACAA
TACTTTTCCTCAGCAAAGTATGCCAAAGAAGGTCTTATTCGCAAACCAATATTTGATAATTTCCGACCCCCTCCACTAACTCCCGAGGAC
GTTGGCTTTGCATCTGGTTTTTCTGCATCTGGTACCGCTGCTTCAGCCCGATTGTTTTCGCCACTCCATTCTGGAACAAGGTTTGATATG
CACAAAAGGAGCCCTCTTCTGAGAGCTCCAAGATTTACTCCAAGTGAGGCTCACTCTAGAATATTTGAGTCTGTAACCTTGCCTAGTAAT
CGAACTTCTGCTGGAACATCTTCTTCAGGAGTATCCAATAGAAAAAGGAAAAGAAAAGTGTTTAGTCCTATTCGATCTGAACCAAGATCT
CCTTCTCACTCCATGAGGACAAGAAGTGGAAGGCTTAGTAGTTCTGAGCTCTCACCTCTCACCCCCCCGTCTTCTGTCTCTTCCTCGTTA
AGCATTTCTGTTAGTCCTCTTGCCACTAGTGCCTTAAACCCAACTTTTACTTTTCCTTCTCATTCCCTGACTCAGTCTGGGGAATCTGCA
GAGAAAAATCAGAGACCAAGGAAGCAGACTAGTGCTCCGGCAGAGCCATTTTCATCAAGTAGTCCTACTCCTCTCTTCCCTTGGTTTACC
CCAGGCTCTCAGACTGAAAGAGGGAGAAATAAAGACAAGGCCCCCGAGGAGCTGTCCAAAGATCGAGATGCTGACAAGAGCGTGGAGAAG
GACAAGAGTAGAGAGAGAGACCGGGAGAGAGAAAAGGAGAATAAGCGGGAGTCAAGGAAAGAGAAAAGGAAAAAGGGATCAGAAATTCAG
AGTAGTTCTGCTTTGTATCCTGTGGGTAGGGTTTCCAAAGAGAAGGTTGTTGGTGAAGATGTTGCCACTTCATCTTCTGCCAAAAAAGCA
ACAGGGCGGAAGAAGTCTTCATCACATGATTCTGGGACTGATATTACTTCTGTGACTCTTGGGGATACAACAGCTGTCAAAACCAAAATA
CTTATAAAGAAAGGGAGAGGAAATCTGGAAAAAACCAACTTGGACCTCGGCCCAACTGCCCCATCCCTGGAGAAGGAGAAAACCCTCTGC
CTTTCCACTCCTTCATCTAGCACTGTTAAACATTCCACTTCCTCCATAGGCTCCATGTTGGCTCAGGCAGACAAGCTTCCAATGACTGAC
AAGAGGGTTGCCAGCCTCCTAAAAAAGGCCAAAGCTCAGCTCTGCAAGATTGAGAAGAGTAAGAGTCTTAAACAAACCGACCAGCCCAAA
GCACAGGGTCAAGAAAGTGACTCATCAGAGACCTCTGTGCGAGGACCCCGGATTAAACATGTCTGCAGAAGAGCAGCTGTTGCCCTTGGC
CGAAAACGAGCTGTGTTTCCTGATGACATGCCCACCCTGAGTGCCTTACCATGGGAAGAACGAGAAAAGATTTTGTCTTCCATGGGGAAT
GATGACAAGTCATCAATTGCTGGCTCAGAAGATGCTGAACCTCTTGCTCCACCCATCAAACCAATTAAACCTGTCACTAGAAACAAGGCA
CCCCAGGAACCTCCAGTAAAGAAAGGACGTCGATCGAGGCGGTGTGGGCAGTGTCCCGGCTGCCAGGTGCCTGAGGACTGTGGTGTTTGT
ACTAATTGCTTAGATAAGCCCAAGTTTGGTGGTCGCAATATAAAGAAGCAGTGCTGCAAGATGAGAAAATGTCAGAATCTACAATGGATG
CCTTCCAAAGCCTACCTGCAGAAGCAAGCTAAAGCTGTGAAAAAGAAAGAGAAAAAGTCTAAGACCAGTGAAAAGAAAGACAGCAAAGAG
AGCAGTGTTGTGAAGAACGTGGTGGACTCTAGTCAGAAACCTACCCCATCAGCAAGAGAGGATCCTGCCCCAAAGAAAAGCAGTAGTGAG
CCTCCTCCACGAAAGCCCGTCGAGGAAAAGAGTGAAGAAGGGAATGTCTCGGCCCCTGGGCCTGAATCCAAACAGGCCACCACTCCAGCT
TCCAGGAAGTCAAGCAAGCAGGTCTCCCAGCCAGCACTGGTCATCCCGCCTCAGCCACCTACTACAGGACCGCCAAGAAAAGAAGTTCCC
AAAACCACTCCTAGTGAGCCCAAGAAAAAGCAGCCTCCACCACCAGAATCAGGTCCAGAGCAGAGCAAACAGAAAAAAGTGGCTCCCCGC
CCAAGTATCCCTGTAAAACAAAAACCAAAAGAAAAGGAAAAACCACCTCCGGTCAATAAGCAGGAGAATGCAGGCACTTTGAACATCCTC
AGCACTCTCTCCAATGGCAATAGTTCTAAGCAAAAAATTCCAGCAGATGGAGTCCACAGGATCAGAGTGGACTTTAAGGAGGATTGTGAA
GCAGAAAATGTGTGGGAGATGGGAGGCTTAGGAATCTTGACTTCTGTTCCTATAACACCCAGGGTGGTTTGCTTTCTCTGTGCCAGTAGT
GGGCATGTAGAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATACAGGCAATACTGGAAGGGTGTTGGCTTCT
GATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGATTTAGCCGACACAGATGGCAAAGGTATC
CTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGAAGTTTCACTAAGTAGTTTGAACCTGGCT
GTTCCTCCACCAAGATTTCATGATACCAGTAGTCCTTTGCTAATCAGTGGAACCTCTGCAGCTGAGCTCCCATGGGCTGTAAAACCTGAA
GATAAGGCCAAATATGATGCAATATTTGATAGTTTAAGCCCAGTGAATGGATTTCTGTCTGGTGATAAAGTGAAACCAGTGTTGCTCAAC
TCTAAGTTACCTGTGGATATCCTTGGAAGAGTTTGGGAGTTGAGTGATATTGACCATGATGGAATGCTTGACAGAGATGAGTTTGCAGTT
GCCATGTTTTTGGTATACTGTGCACTGGAGAAAGAACCTGTGCCAATGTCCTTGCCTCCAGCCTTGGTGCCACCATCTAAGAGAAAAACG
TGGGTTGTATCCCCTGCAGAAAAAGCTAAATATGATGAAATCTTCCTGAAAACTGATAAAGATATGGACGGATTTGTGTCTGGATTGGAG
GTCCGTGAAATATTCTTGAAAACAGGTTTACCTTCTACCTTACTAGCCCATATATGGTCATTATGCGACACAAAGGACTGTGGGAAGCTT
TCAAAGGATCAGTTTGCCTTGGCTTTTCACTTAATCAGTCAGAAGTTAATCAAGGGCATTGATCCTCCTCACGTTCTTACTCCTGAAATG
ATTCCACCATCAGACAGGGCCAGTTTACAAAAGAACATCATAGGATCAAGTCCTGTTGCAGATTTCTCTGCTATTAAGGAACTAGATACT
CTTAACAATGAAATAGTTGACCTACAGAGGGAAAAGAATAATGTGGAACAGGACCTTAAGGAGAAGGAAGATACTATTAAACAGAGGACA
AGTGAGGTTCAGGATCTTCAAGATGAAGTTCAAAGGGAGAATACTAATCTGCAAAAACTACAGGCCCAGAAACAGCAGGTACAGGAACTC
CTTGATGAACTGGATGAGCAGAAAGCCCAGCTGGAGGAGCAACTCAAGGAAGTCAGAAAGAAATGTGCTGAGGAGGCCCAACTGATCTCT
TCTCTGAAAGCTGAATTAACTAGTCAGGAATCGCAGATCTCCACTTACGAAGAAGAATTGGCAAAAGCTAGAGAAGAGCTGAGCCGTCTA
CAGCAAGAAACAGCAGAATTGGAGGAGAGTGTAGAGTCAGGGAAGGCTCAGTTGGAACCTCTTCAGCAGCACCTACAAGATTCACAACAG
GAAATTAGTTCAATGCAAATGAAACTGATGGAAATGAAAGATTTGGAAAATCATAATAGTCAGTTAAATTGGTGCAGTAGCCCACACAGC
ATTCTTGTAAACGGAGCTACAGATTATTGCAGCCTCAGCACCAGCAGCAGTGAAACAGCCAACCTTAATGAACATGTTGAAGGCCAGAGC
AACCTAGAGTCTGAGCCCATACACCAGGAATCTCCAGCAAGAAGTAGTCCTGAACTACTGCCTTCTGGTGTGACTGATGAAAATGAGGTG
ACTACAGCTGTTACTGAAAAAGTTTGTTCTGAACTCGACAATAATAGACATTCAAAAGAGGAAGATCCATTTAATGTAGACTCAAGTTCG
CTGACAGGTCCAGTTGCAGATACAAACTTGGATTTTTTCCAGTCTGATCCTTTTGTTGGCAGTGATCCTTTCAAGGATGATCCTTTTGGA
AAAATCGATCCATTTGGTGGTGATCCTTTCAAAGGTTCAGATCCATTTGCATCAGACTGTTTCTTCAGGCAATCTACTGATCCTTTTGCC
ACTTCAAGCACTGACCCTTTCAGTGCAGCCAACAATAGCAGTATTACATCGGTAGAAACGTTGAAGCACAATGATCCTTTTGCTCCTGGT
GGAACAGTTGTTGCAGCAAGCGATTCAGCCACAGACCCCTTTGCTTCTGTTTTTGGGAATGAATCATTTGGAGGTGGATTTGCTGACTTC
AGCACATTGTCAAAGGTCAACAATGAAGATCCTTTTCGTTCAGCCACATCGAGCTCTGTCAGCAACGTAGTGATTACAAAAAATGTATTT
GAGGAAACATCGGTCAAAAGTGAAGATGAACCCCCAGCACTGCCACCAAAGATCGGAACTCCAACAAGACCCTGCCCTCTACCACCTGGG
AAAAGATCCATCAACAAATTGGATTCTCCTGATCCCTTTAAACTGAATGATCCATTTCAGCCTTTCCCAGGCAACGATAGCCCCAAAGAA
AAAGATCCTGAAATATTTTGTGATCCATTCACTTCTGCTACTACCACTACCAATAAAGAGGCTGATCCAAGCAATTTTGCCAACTTCAGT
GCTTATCCCTCTGAAGAAGATATGATCGAATGGGCCAAGAGGGAAAGTGAGAGAGAGGAAGAGCAGAGGCTTGCCCGACTAAATCAGCAG
GAACAAGAAGACTTAGAACTGGCTATTGCACTCAGCAAATCTGAGATATCAGAAGCATGAAGAATTCTCTTGTTCTTTGGCAACAATATA
GTATTCTTCTTCCTGAATACTGAAACTATTTACAATGTGTATCAAAACTACCTGTGAGCATGGGAATACAAAAGGTTTGAGATTCCTGTA
AATGTGACAAAATTTTAGGATTTTTTTTTTTTCTTCATTACAGATTCGTCTTTTTTTTTTTTTCTTATAAAAGCCGTAACCCAGTCAGAC
AAATTCACCTTCACTTAGGCCCCTGTTCTGGTATACATTTACTGTGAGCTTTTGCCTGCCTGTGCTATTTTACTTGTAAAGCTAGAGCAC
CCAAGCTTCTGCCTTCTGGAATATAGAGAAATAGTTTCACCCTGCACTACCCTGTTCTGTAGTTATTCTGATGATAGCCAGTGAGGTTCT
TAAAGTTTGCAGTATTCTCCCCTGATTGGAATGGTTGAGTGAGGGTAAGGGAAAGAATATCTTATTTCTTTTATGATTGGTGCAAATTGG
CTAAAGTGCATTTTTAAATTTCCTCTACTTAATTTGTTTTTCAGAGATAAGGAAAAATATTTTGCACAGATTTACTCCACTATGGAAAAG
GGATGCTGTAGGTTGAACCATTATAGCCTCAGATTCGATCTTTTCCTAACTAAAAATATTAAAGCCTCATGTGTGAAATAAATTTTTAAA
AAGATTTATCTGGATTTAGAGAATTTTAGATCAACAGATACCTCTCAGTGTGTTTGCTAATTAATAAAAATCAGTTTCTTACAAATAAAG
TTTGTAAGAAAATGTTCATTTTAAGTGATAGATAGTGGAGAAAATTTATCACCTAAAATATACCCATCAGTATAAGGCAAGCAAAAGTCT
TAACATGGCAGCCATTCTGCCTTTGCCGTGGCCCTGTCCTGTTTAGTTCTTAGTGGGTTAATTTTTGTACTTTTGCAGAAGAAACTTCAG
CAAGCTAGAACTGGAAGGTACTTTAATTTTTCATATATATTTGTTTTTTTTTTTTTAATGAAGGCTCATTTACTTGAAATGTAAAAACTT
TCACTGAATACAAATAGAAAAAGTGATGTGTTTTATATCATATTGCTTTTTGTCCATCTTTGTGGTTTAGTTTATTTACTCACTTCATGT
TTTTCACCTATAAAATTGTCAAGCTAGCAAAAAAACTCTTGTTTTTTTAATTGGGAGAGAAGAGACCTGCCAGATTATCAGACCTCTTCA
TGTTAAAAGACCATCTCCTGTAAAACTGACCTAGTGGACAAGCTGAATTTGAAATAGACTGTGAAGTAAGCTGTAACTTGTCATTTTAAT
TTTGTTTAACACGGTTACTGACTTAGATGATGTATTAAATACCAAGATAAAGAAAAATGCACCTAAAATCTAATTAGAATTCTCTGGGTC
AACAAGTCAAGGTGGTATTGATCTGTGTTAATCTGAGTAACTTATTGCCTAGCCTATAAATAAATTCCAAAATATCCAATTCATTTCTTC
TTGAAATGGTGCTTGTTTTGTTTTCTTTCCATTACACAATTAGACTCCTACAGTTTAAAACAAACTTTAAACCACTATCTTGCACTGCTA
ACTTTTTTCTACCTTTGTAAATAGAAACATTTCTGCATAAAAGTCATACATATGAAGCAAGGGCTGAATCATAATCACAAGGCTTAATTT
TGATAAACGAATCCAGTGACCTAAGGATTTTCTGCAAAATTTGACTGGGAGTTGTGATAGGTGGTATTTTTGTTTATTTTCTTCCTCTTA
CTCCTTAGGATAAAGGTAAGTTGACTTGAACAACTTTCTTTTGCACTGGGAAAATAAGCAAATGTTTAAATGCTTCAAAAAAATTTTCAA
TTAAACTCAAATATTAAATATCTATAACTTATAAACACCAACTTTCAATGTAATAAATGTATCCTAATCTTATGTATGTTTAACTGGATT
ACATAGATTTTTATCTTTTGTTAAAATGTGTATACCCCGTGGACCAACATAATATTAAAGTATGTATATATTATATAAATATATATGTAT
ATGTGCTCGCTTGTGTAGGATGAATGTCTTAGAGTCGTTTGTGGTATTTTATGTTGTTGACTCTGGCTCCAGGGCCTGTGCTTGAAAAGG
ACAGATAAGTATTGCCCAGAGCTAAGTGGCACTACTTACAAAGTTTTAAATGTCTTCTACATACTGATTCATGTTTATTTGAGCTCTCTT
TATAGAATTTTCTCTTAAAGTTTCAAACCTCTAAGTTGTAGCCTGTAATTATGAGAACAGTAAACTTTAAGTAATAATAAAGAATCCCAT
CCATATATCCAATTTGCAATTGAGTTTTGCATGGTTCTCTGATTATGTCCATGCTGTGTCCAAGGAGGAGTAGGTACATACAATCAGCAC

>In-frame_ENST00000389506_ENST00000371733_AY187922_KMT2A_chr11_118355690_+_EPS15_chr1_51946988_length(amino acids)=2329AA_start in transcript=0_stop in transcript=6989
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSAS
SSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKI
KKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQ
YFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESA
EKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLC
LSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVC
TNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLA
VPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAV
AMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL
SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRT
SEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL
QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQS
NLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFG
KIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADF
STLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKE

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Fusion Gene PPI Analysis for KMT2A-EPS15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKMT2Achr11:118355690chr1:51946988ENST00000354520+1351584_16000.03932.0histone H3K4me3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000389506+10361584_16001444.03970.0histone H3K4me3
HgeneKMT2Achr11:118355690chr1:51946988ENST00000534358+10361584_16001444.03973.0histone H3K4me3
TgeneEPS15chr11:118355690chr1:51946988ENST000003717330252_33011.0897.0DAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2A-EPS15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2A-EPS15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
HgeneKMT2AC0023418leukemia2CTD_human
HgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
HgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
HgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
HgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneKMT2AC0023470Myeloid Leukemia2CTD_human
HgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
HgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
HgeneKMT2AC0001418Adenocarcinoma1CTD_human
HgeneKMT2AC0004403Autosome Abnormalities1CTD_human
HgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneKMT2AC0005695Bladder Neoplasm1CTD_human
HgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKMT2AC0008625Chromosome Aberrations1CTD_human
HgeneKMT2AC0023448Lymphoid leukemia1CTD_human
HgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
HgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
HgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
HgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
HgeneKMT2AC0036341Schizophrenia1PSYGENET
HgeneKMT2AC0038356Stomach Neoplasms1CTD_human
HgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
HgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
HgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
HgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
HgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
HgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
HgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
HgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
HgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneKMT2AC2239176Liver carcinoma1CTD_human
HgeneKMT2AC2930974Acute erythroleukemia1CTD_human
HgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
HgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
HgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human