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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2A-FLNA (FusionGDB2 ID:42953)

Fusion Gene Summary for KMT2A-FLNA

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2A-FLNA
Fusion gene ID: 42953
HgeneTgene
Gene symbol

KMT2A

FLNA

Gene ID

4297

2316

Gene namelysine methyltransferase 2Afilamin A
SynonymsALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTSABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD
Cytomap

11q23.3

Xq28

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-likefilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filamin
Modification date2020031920200313
UniProtAcc

Q03164

P21333

Ensembl transtripts involved in fusion geneENST00000534358, ENST00000389506, 
ENST00000354520, ENST00000420751, 
ENST00000360319, ENST00000422373, 
ENST00000369850, ENST00000369856, 
ENST00000344736, ENST00000498491, 
Fusion gene scores* DoF score79 X 196 X 13=20129225 X 31 X 6=4650
# samples 24131
** MAII scorelog2(241/201292*10)=-6.38411287931608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/4650*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2A [Title/Abstract] AND FLNA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2A(118353919)-FLNA(153590912), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

HgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

HgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

HgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

HgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

HgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722

TgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

TgeneFLNA

GO:0030334

regulation of cell migration

16291724

TgeneFLNA

GO:0031532

actin cytoskeleton reorganization

10051605

TgeneFLNA

GO:0034394

protein localization to cell surface

18322202

TgeneFLNA

GO:0043113

receptor clustering

10692483

TgeneFLNA

GO:0043433

negative regulation of DNA-binding transcription factor activity

15684392

TgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

TgeneFLNA

GO:0045184

establishment of protein localization

18322202

TgeneFLNA

GO:0051764

actin crosslink formation

10051605

TgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

TgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

TgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510


check buttonFusion gene breakpoints across KMT2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FLNA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AKJ754384KMT2Achr11

118353919

+FLNAchrX

153590912

-
ChiTaRS5.0N/AKJ754385KMT2Achr11

118353919

+FLNAchrX

153590912

-


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Fusion Gene ORF analysis for KMT2A-FLNA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000534358ENST00000360319KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000534358ENST00000422373KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000534358ENST00000369850KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000534358ENST00000369856KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000534358ENST00000344736KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000534358ENST00000498491KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000389506ENST00000360319KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000389506ENST00000422373KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000389506ENST00000369850KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000389506ENST00000369856KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000389506ENST00000344736KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000389506ENST00000498491KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000354520ENST00000360319KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000354520ENST00000422373KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000354520ENST00000369850KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000354520ENST00000369856KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000354520ENST00000344736KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000354520ENST00000498491KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000420751ENST00000360319KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000420751ENST00000422373KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-3CDSENST00000420751ENST00000369850KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000420751ENST00000369856KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000420751ENST00000344736KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000420751ENST00000498491KMT2Achr11

118353919

+FLNAchrX

153590912

-
intron-intronENST00000354520ENST00000344736KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000354520ENST00000344736KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000354520ENST00000360319KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000354520ENST00000360319KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000354520ENST00000369850KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000354520ENST00000369850KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000354520ENST00000369856KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000354520ENST00000369856KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000354520ENST00000422373KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000354520ENST00000422373KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000354520ENST00000498491KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000354520ENST00000498491KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000389506ENST00000344736KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000389506ENST00000344736KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000389506ENST00000360319KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000389506ENST00000360319KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000389506ENST00000369850KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000389506ENST00000369850KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000389506ENST00000369856KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000389506ENST00000369856KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000389506ENST00000422373KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000389506ENST00000422373KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000389506ENST00000498491KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000389506ENST00000498491KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000420751ENST00000344736KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000420751ENST00000344736KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000420751ENST00000360319KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000420751ENST00000360319KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000420751ENST00000369850KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000420751ENST00000369850KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000420751ENST00000369856KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000420751ENST00000369856KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000420751ENST00000422373KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000420751ENST00000422373KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000420751ENST00000498491KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000420751ENST00000498491KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000534358ENST00000344736KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000534358ENST00000344736KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000534358ENST00000360319KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000534358ENST00000360319KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000534358ENST00000369850KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000534358ENST00000369850KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000534358ENST00000369856KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000534358ENST00000369856KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000534358ENST00000422373KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000534358ENST00000422373KMT2Achr11

118355576

+FLNAchrX

118355576

-
intron-intronENST00000534358ENST00000498491KMT2Achr11

118354897

+FLNAchrX

118354897

-
intron-intronENST00000534358ENST00000498491KMT2Achr11

118355576

+FLNAchrX

118355576

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KMT2A-FLNA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KMT2A-FLNA


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2A

Q03164

FLNA

P21333

FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KMT2A-FLNA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KMT2A-FLNA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2A-FLNA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2A-FLNA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
HgeneKMT2AC0023418leukemia2CTD_human
HgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
HgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
HgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
HgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneKMT2AC0023470Myeloid Leukemia2CTD_human
HgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
HgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
HgeneKMT2AC0001418Adenocarcinoma1CTD_human
HgeneKMT2AC0004403Autosome Abnormalities1CTD_human
HgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneKMT2AC0005695Bladder Neoplasm1CTD_human
HgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneKMT2AC0008625Chromosome Aberrations1CTD_human
HgeneKMT2AC0023448Lymphoid leukemia1CTD_human
HgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
HgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
HgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
HgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
HgeneKMT2AC0036341Schizophrenia1PSYGENET
HgeneKMT2AC0038356Stomach Neoplasms1CTD_human
HgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
HgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
HgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
HgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
HgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
HgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
HgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
HgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
HgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneKMT2AC2239176Liver carcinoma1CTD_human
HgeneKMT2AC2930974Acute erythroleukemia1CTD_human
HgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
HgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
HgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human
TgeneFLNAC1848213Periventricular Heterotopia, X-Linked9CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFLNAC0025237Melnick-Needles Syndrome7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFLNAC4707243Familial thoracic aortic aneurysm and aortic dissection7CLINGEN;GENOMICS_ENGLAND
TgeneFLNAC0265251Oto-Palato-digital syndrome type 16CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFLNAC1844696OTOPALATODIGITAL SYNDROME, TYPE II6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFLNAC0265293Frontometaphyseal dysplasia5CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneFLNAC1846129Terminal Osseous Dysplasia and Pigmentary Defects4CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneFLNAC4281559FRONTOMETAPHYSEAL DYSPLASIA 14GENOMICS_ENGLAND;UNIPROT
TgeneFLNAC0262436Cardiac valvular dysplasia, X-linked2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFLNAC0543888Epileptic encephalopathy2GENOMICS_ENGLAND
TgeneFLNAC1845902FG SYNDROME 22CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFLNAC1868720Periventricular Nodular Heterotopia2CTD_human
TgeneFLNAC2746068Congenital idiopathic intestinal pseudoobstruction2CTD_human;GENOMICS_ENGLAND
TgeneFLNAC4551969Bilateral Periventricular Nodular Heterotopia2CTD_human
TgeneFLNAC0006142Malignant neoplasm of breast1CTD_human
TgeneFLNAC0010701Phyllodes Tumor1CTD_human
TgeneFLNAC0013366Dyschondroplasias1CTD_human
TgeneFLNAC0014544Epilepsy1CTD_human
TgeneFLNAC0021847Intestinal Pseudo-Obstruction1ORPHANET
TgeneFLNAC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneFLNAC0026760Multiple Epiphyseal Dysplasia1CTD_human
TgeneFLNAC0029422Osteochondrodysplasias1CTD_human
TgeneFLNAC0036391Schwartz-Jampel Syndrome1CTD_human
TgeneFLNAC0038015Spondyloepiphyseal Dysplasia1CTD_human
TgeneFLNAC0086237Epilepsy, Cryptogenic1CTD_human
TgeneFLNAC0220769FG syndrome1CTD_human
TgeneFLNAC0236018Aura1CTD_human
TgeneFLNAC0268341Ehlers-Danlos syndrome type 51ORPHANET
TgeneFLNAC0432272Van Buchem disease1CTD_human
TgeneFLNAC0600066Malignant Cystosarcoma Phyllodes1CTD_human
TgeneFLNAC0678222Breast Carcinoma1CTD_human
TgeneFLNAC0751111Awakening Epilepsy1CTD_human
TgeneFLNAC1257931Mammary Neoplasms, Human1CTD_human
TgeneFLNAC1458155Mammary Neoplasms1CTD_human
TgeneFLNAC1845235Heterotopia, Periventricular, Ehlers-Danlos Variant1CTD_human
TgeneFLNAC1845546FG SYNDROME 4 (disorder)1CTD_human
TgeneFLNAC1845567FG SYNDROME 31CTD_human
TgeneFLNAC1855733Neuronal intestinal pseudoobstruction1ORPHANET
TgeneFLNAC2751260Macrothrombocytopenia1GENOMICS_ENGLAND
TgeneFLNAC3541456Spondyloepiphyseal Dysplasia Tarda, X-Linked1CTD_human
TgeneFLNAC4551479Schwartz-Jampel Syndrome, Type 11CTD_human
TgeneFLNAC4704874Mammary Carcinoma, Human1CTD_human